{
  "dbId" : 10912728,
  "stableId" : "R-DME-5221030",
  "displayName" : "TET1,2,3 and TDG demethylate DNA",
  "nodes" : [ {
    "id" : 33030,
    "reactomeId" : 10836067,
    "displayName" : "Tdg",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 590,
      "y" : 697
    },
    "minX" : 562,
    "maxX" : 760,
    "minY" : 567,
    "maxY" : 839,
    "prop" : {
      "x" : 562,
      "y" : 686,
      "width" : 56,
      "height" : 22
    },
    "textPosition" : {
      "x" : 574,
      "y" : 686
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 618,
          "y" : 686
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 618,
          "y" : 686
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33029,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 599,
          "y" : 683
        },
        "to" : {
          "x" : 701,
          "y" : 567
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33029,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 603,
          "y" : 683
        },
        "to" : {
          "x" : 741,
          "y" : 575
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 745,
          "y" : 572
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 745,
          "y" : 572
        }
      }
    }, {
      "edgeId" : 33034,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 599,
          "y" : 711
        },
        "to" : {
          "x" : 711,
          "y" : 839
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33034,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 603,
          "y" : 711
        },
        "to" : {
          "x" : 752,
          "y" : 829
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 756,
          "y" : 832
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 756,
          "y" : 832
        }
      }
    } ]
  }, {
    "id" : 33031,
    "reactomeId" : 5221062,
    "displayName" : "DNA containing 5-fC",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 549,
      "y" : 565
    },
    "minX" : 477,
    "maxX" : 701,
    "minY" : 551,
    "maxY" : 580,
    "prop" : {
      "x" : 477,
      "y" : 551,
      "width" : 144,
      "height" : 29
    },
    "textPosition" : {
      "x" : 483,
      "y" : 555
    },
    "connectors" : [ {
      "edgeId" : 33029,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 624,
          "y" : 565
        },
        "to" : {
          "x" : 701,
          "y" : 567
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33032,
    "reactomeId" : 10836085,
    "displayName" : "TDG:AP-dsDNA",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 875,
      "y" : 697
    },
    "minX" : 761,
    "maxX" : 995,
    "minY" : 565,
    "maxY" : 840,
    "prop" : {
      "x" : 761,
      "y" : 679,
      "width" : 228,
      "height" : 37
    },
    "textPosition" : {
      "x" : 826,
      "y" : 695
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 989,
          "y" : 679
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 989,
          "y" : 679
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33029,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 865,
          "y" : 676
        },
        "to" : {
          "x" : 809,
          "y" : 565
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 858,
          "y" : 672
        },
        "b" : {
          "x" : 865,
          "y" : 676
        },
        "c" : {
          "x" : 865,
          "y" : 668
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 865,
          "y" : 668
        }
      }
    }, {
      "edgeId" : 33034,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 868,
          "y" : 719
        },
        "to" : {
          "x" : 822,
          "y" : 840
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 869,
          "y" : 727
        },
        "b" : {
          "x" : 868,
          "y" : 719
        },
        "c" : {
          "x" : 862,
          "y" : 724
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 862,
          "y" : 724
        }
      }
    } ]
  }, {
    "id" : 33033,
    "reactomeId" : 5221065,
    "displayName" : "5-fC",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 889,
      "y" : 536
    },
    "minX" : 809,
    "maxX" : 916,
    "minY" : 519,
    "maxY" : 565,
    "prop" : {
      "x" : 864,
      "y" : 520,
      "width" : 51,
      "height" : 32
    },
    "textPosition" : {
      "x" : 873,
      "y" : 525
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 910,
          "y" : 525
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 910,
          "y" : 525
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33029,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 861,
          "y" : 545
        },
        "to" : {
          "x" : 809,
          "y" : 565
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 856,
          "y" : 551
        },
        "b" : {
          "x" : 861,
          "y" : 545
        },
        "c" : {
          "x" : 853,
          "y" : 544
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 853,
          "y" : 544
        }
      }
    } ]
  }, {
    "id" : 33035,
    "reactomeId" : 5220996,
    "displayName" : "DNA containing 5-caC",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 550,
      "y" : 841
    },
    "minX" : 469,
    "maxX" : 711,
    "minY" : 825,
    "maxY" : 857,
    "prop" : {
      "x" : 469,
      "y" : 825,
      "width" : 163,
      "height" : 32
    },
    "textPosition" : {
      "x" : 479,
      "y" : 830
    },
    "connectors" : [ {
      "edgeId" : 33034,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 635,
          "y" : 839
        },
        "to" : {
          "x" : 711,
          "y" : 839
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33036,
    "reactomeId" : 5221064,
    "displayName" : "5-caC",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 899,
      "y" : 867
    },
    "minX" : 822,
    "maxX" : 926,
    "minY" : 840,
    "maxY" : 882,
    "prop" : {
      "x" : 874,
      "y" : 852,
      "width" : 51,
      "height" : 30
    },
    "textPosition" : {
      "x" : 878,
      "y" : 856
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 920,
          "y" : 857
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 920,
          "y" : 857
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33034,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 871,
          "y" : 858
        },
        "to" : {
          "x" : 822,
          "y" : 840
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 863,
          "y" : 859
        },
        "b" : {
          "x" : 871,
          "y" : 858
        },
        "c" : {
          "x" : 866,
          "y" : 852
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 866,
          "y" : 852
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 33029,
    "reactomeId" : 10876561,
    "displayName" : "TDG excises 5-formylcytosine",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 754,
      "y" : 565
    },
    "minX" : 701,
    "maxX" : 809,
    "minY" : 559,
    "maxY" : 571,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 701,
        "y" : 567
      },
      "to" : {
        "x" : 754,
        "y" : 565
      }
    }, {
      "from" : {
        "x" : 754,
        "y" : 565
      },
      "to" : {
        "x" : 809,
        "y" : 565
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 748,
        "y" : 559
      },
      "b" : {
        "x" : 760,
        "y" : 571
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 754,
        "y" : 565
      }
    },
    "inputs" : [ {
      "id" : 33030,
      "points" : [ {
        "x" : 599,
        "y" : 683
      } ]
    }, {
      "id" : 33031,
      "points" : [ {
        "x" : 624,
        "y" : 565
      } ]
    } ],
    "outputs" : [ {
      "id" : 33032,
      "points" : [ {
        "x" : 865,
        "y" : 676
      } ]
    }, {
      "id" : 33033,
      "points" : [ {
        "x" : 861,
        "y" : 545
      } ]
    } ],
    "catalysts" : [ {
      "id" : 33030,
      "points" : [ {
        "x" : 603,
        "y" : 683
      } ]
    } ]
  }, {
    "id" : 33034,
    "reactomeId" : 10876563,
    "displayName" : "TDG excises 5-carboxylcytosine",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 765,
      "y" : 839
    },
    "minX" : 711,
    "maxX" : 822,
    "minY" : 833,
    "maxY" : 845,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 711,
        "y" : 839
      },
      "to" : {
        "x" : 765,
        "y" : 839
      }
    }, {
      "from" : {
        "x" : 765,
        "y" : 839
      },
      "to" : {
        "x" : 822,
        "y" : 840
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 759,
        "y" : 833
      },
      "b" : {
        "x" : 771,
        "y" : 845
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 765,
        "y" : 839
      }
    },
    "inputs" : [ {
      "id" : 33035,
      "points" : [ {
        "x" : 635,
        "y" : 839
      } ]
    }, {
      "id" : 33030,
      "points" : [ {
        "x" : 599,
        "y" : 711
      } ]
    } ],
    "outputs" : [ {
      "id" : 33032,
      "points" : [ {
        "x" : 868,
        "y" : 719
      } ]
    }, {
      "id" : 33036,
      "points" : [ {
        "x" : 871,
        "y" : 858
      } ]
    } ],
    "catalysts" : [ {
      "id" : 33030,
      "points" : [ {
        "x" : 603,
        "y" : 711
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 33037,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 535,
      "y" : 506
    },
    "minX" : 0,
    "maxX" : 1071,
    "minY" : 0,
    "maxY" : 1013,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1071,
      "height" : 1013
    },
    "textPosition" : {
      "x" : 13,
      "y" : 968
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1051,
      "height" : 993
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 33038 ]
  }, {
    "id" : 33038,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 538,
      "y" : 498
    },
    "minX" : 44,
    "maxX" : 1033,
    "minY" : 34,
    "maxY" : 963,
    "prop" : {
      "x" : 44,
      "y" : 34,
      "width" : 989,
      "height" : 929
    },
    "textPosition" : {
      "x" : 65,
      "y" : 880
    },
    "insets" : {
      "x" : 54,
      "y" : 44,
      "width" : 969,
      "height" : 909
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 33031, 33035, 33030, 33029, 33032, 33033, 33034, 33036 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1071,
  "minY" : 0,
  "maxY" : 1013,
  "disease" : false
}