{ "dbId" : 10911156, "stableId" : "R-DME-453274", "displayName" : "Mitotic G2-G2/M phases", "nodes" : [ { "id" : 105473, "reactomeId" : 10871666, "displayName" : "phospho-p-S177-OPTN", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 884, "y" : 1850 }, "minX" : 832, "maxX" : 942, "minY" : 1795, "maxY" : 1862, "prop" : { "x" : 832, "y" : 1839, "width" : 104, "height" : 23 }, "textPosition" : { "x" : 844, "y" : 1833 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 936, "y" : 1839 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 936, "y" : 1839 } } }, "connectors" : [ { "edgeId" : 105472, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105476, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 884, "y" : 1836 }, "to" : { "x" : 886, "y" : 1795 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 890, "y" : 1802 }, "b" : { "x" : 886, "y" : 1795 }, "c" : { "x" : 882, "y" : 1802 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 882, "y" : 1802 } } } ] }, { "id" : 105475, "reactomeId" : 10837539, "displayName" : "phospho-p-T210-PLK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 762, "y" : 1726 }, "minX" : 711, "maxX" : 843, "minY" : 1708, "maxY" : 1787, "prop" : { "x" : 711, "y" : 1714, "width" : 102, "height" : 24 }, "textPosition" : { "x" : 722, "y" : 1709 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 813, "y" : 1714 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 813, "y" : 1714 } } }, "connectors" : [ { "edgeId" : 105474, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105476, "type" : "INPUT", "segments" : [ { "from" : { "x" : 777, "y" : 1741 }, "to" : { "x" : 843, "y" : 1787 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105477, "reactomeId" : 113518, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 784, "y" : 1818 }, "minX" : 763, "maxX" : 843, "minY" : 1787, "maxY" : 1830, "prop" : { "x" : 763, "y" : 1807, "width" : 42, "height" : 23 }, "textPosition" : { "x" : 767, "y" : 1808 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 800, "y" : 1812 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 800, "y" : 1812 } } }, "connectors" : [ { "edgeId" : 105476, "type" : "INPUT", "segments" : [ { "from" : { "x" : 805, "y" : 1804 }, "to" : { "x" : 843, "y" : 1787 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 105479, "reactomeId" : 113550, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 933, "y" : 1818 }, "minX" : 917, "maxX" : 950, "minY" : 1786, "maxY" : 1828, "prop" : { "x" : 917, "y" : 1808, "width" : 32, "height" : 20 }, "textPosition" : { "x" : 923, "y" : 1808 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 944, "y" : 1813 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 944, "y" : 1813 } } }, "connectors" : [ { "edgeId" : 105476, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 930, "y" : 1805 }, "to" : { "x" : 925, "y" : 1786 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 924, "y" : 1799 }, "b" : { "x" : 930, "y" : 1805 }, "c" : { "x" : 932, "y" : 1797 }, "type" : "ARROW", "centre" : { "x" : 932, "y" : 1797 } } } ] }, { "id" : 105478, "reactomeId" : 10872548, "displayName" : "PLK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 942, "y" : 1764 }, "minX" : 916, "maxX" : 974, "minY" : 1748, "maxY" : 1786, "prop" : { "x" : 916, "y" : 1754, "width" : 52, "height" : 21 }, "textPosition" : { "x" : 923, "y" : 1754 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 968, "y" : 1754 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 968, "y" : 1754 } } }, "connectors" : [ { "edgeId" : 105476, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 933, "y" : 1778 }, "to" : { "x" : 925, "y" : 1786 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 931, "y" : 1786 }, "b" : { "x" : 933, "y" : 1778 }, "c" : { "x" : 925, "y" : 1780 }, "type" : "ARROW", "centre" : { "x" : 925, "y" : 1780 } } } ] }, { "id" : 105480, "reactomeId" : 10872562, "displayName" : "Phosphorylated Myosin Phosphatase", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 889, "y" : 1725 }, "minX" : 827, "maxX" : 958, "minY" : 1701, "maxY" : 1778, "prop" : { "x" : 827, "y" : 1707, "width" : 125, "height" : 36 }, "textPosition" : { "x" : 834, "y" : 1694 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 952, "y" : 1707 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 952, "y" : 1707 } } }, "connectors" : [ { "edgeId" : 105476, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 888, "y" : 1746 }, "to" : { "x" : 887, "y" : 1770 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 887, "y" : 1774 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 887, "y" : 1774 } } } ] }, { "id" : 105483, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 831, "y" : 2066 }, "minX" : 813, "maxX" : 902, "minY" : 2049, "maxY" : 2081, "prop" : { "x" : 813, "y" : 2052, "width" : 36, "height" : 29 }, "textPosition" : { "x" : 815, "y" : 2056 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 844, "y" : 2057 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 844, "y" : 2057 } } }, "connectors" : [ { "edgeId" : 105481, "type" : "INPUT", "segments" : [ { "from" : { "x" : 852, "y" : 2066 }, "to" : { "x" : 894, "y" : 2069 } } ], "stoichiometry" : { "value" : 9, "shape" : { "a" : { "x" : 867, "y" : 2061 }, "b" : { "x" : 879, "y" : 2073 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 873, "y" : 2067 } } } }, { "edgeId" : 105529, "type" : "INPUT", "segments" : [ { "from" : { "x" : 852, "y" : 2061 }, "to" : { "x" : 902, "y" : 2050 } } ], "stoichiometry" : { "value" : 9, "shape" : { "a" : { "x" : 871, "y" : 2049 }, "b" : { "x" : 883, "y" : 2061 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 877, "y" : 2055 } } } } ] }, { "id" : 105482, "reactomeId" : 10874990, "displayName" : "bora", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 880, "y" : 2020 }, "minX" : 859, "maxX" : 907, "minY" : 2003, "maxY" : 2069, "prop" : { "x" : 859, "y" : 2009, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 861, "y" : 2009 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 901, "y" : 2009 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 901, "y" : 2009 } } }, "connectors" : [ { "edgeId" : 105481, "type" : "INPUT", "segments" : [ { "from" : { "x" : 883, "y" : 2034 }, "to" : { "x" : 894, "y" : 2069 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105529, "type" : "INPUT", "segments" : [ { "from" : { "x" : 888, "y" : 2034 }, "to" : { "x" : 902, "y" : 2050 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105485, "reactomeId" : 10872499, "displayName" : "phospho-bora", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 904, "y" : 2190 }, "minX" : 849, "maxX" : 966, "minY" : 2123, "maxY" : 2212, "prop" : { "x" : 849, "y" : 2169, "width" : 111, "height" : 43 }, "textPosition" : { "x" : 856, "y" : 2180 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 960, "y" : 2169 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 960, "y" : 2169 } } }, "connectors" : [ { "edgeId" : 105481, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 899, "y" : 2166 }, "to" : { "x" : 890, "y" : 2123 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 894, "y" : 2160 }, "b" : { "x" : 899, "y" : 2166 }, "c" : { "x" : 901, "y" : 2158 }, "type" : "ARROW", "centre" : { "x" : 901, "y" : 2158 } } }, { "edgeId" : 105529, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 908, "y" : 2166 }, "to" : { "x" : 914, "y" : 2141 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 906, "y" : 2158 }, "b" : { "x" : 908, "y" : 2166 }, "c" : { "x" : 914, "y" : 2160 }, "type" : "ARROW", "centre" : { "x" : 914, "y" : 2160 } } } ] }, { "id" : 105484, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 834, "y" : 2139 }, "minX" : 817, "maxX" : 914, "minY" : 2122, "maxY" : 2154, "prop" : { "x" : 817, "y" : 2125, "width" : 35, "height" : 29 }, "textPosition" : { "x" : 818, "y" : 2129 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 847, "y" : 2130 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 847, "y" : 2130 } } }, "connectors" : [ { "edgeId" : 105481, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 855, "y" : 2134 }, "to" : { "x" : 890, "y" : 2123 } } ], "stoichiometry" : { "value" : 9, "shape" : { "a" : { "x" : 866, "y" : 2122 }, "b" : { "x" : 878, "y" : 2134 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 872, "y" : 2128 } } }, "endShape" : { "a" : { "x" : 860, "y" : 2128 }, "b" : { "x" : 855, "y" : 2134 }, "c" : { "x" : 863, "y" : 2136 }, "type" : "ARROW", "centre" : { "x" : 863, "y" : 2136 } } }, { "edgeId" : 105529, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 855, "y" : 2139 }, "to" : { "x" : 914, "y" : 2141 } } ], "stoichiometry" : { "value" : 9, "shape" : { "a" : { "x" : 878, "y" : 2134 }, "b" : { "x" : 890, "y" : 2146 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 884, "y" : 2140 } } }, "endShape" : { "a" : { "x" : 862, "y" : 2135 }, "b" : { "x" : 855, "y" : 2139 }, "c" : { "x" : 862, "y" : 2143 }, "type" : "ARROW", "centre" : { "x" : 862, "y" : 2143 } } } ] }, { "id" : 105487, "reactomeId" : 10840171, "displayName" : "AURKA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 314, "y" : 2431 }, "minX" : 188, "maxX" : 345, "minY" : 2378, "maxY" : 2442, "prop" : { "x" : 290, "y" : 2420, "width" : 49, "height" : 22 }, "textPosition" : { "x" : 290, "y" : 2420 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 339, "y" : 2420 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 339, "y" : 2420 } } }, "connectors" : [ { "edgeId" : 105486, "type" : "INPUT", "segments" : [ { "from" : { "x" : 287, "y" : 2420 }, "to" : { "x" : 188, "y" : 2378 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105489, "reactomeId" : 10894335, "displayName" : "SCF-FBXL7:AURKA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 148, "y" : 2451 }, "minX" : 104, "maxX" : 199, "minY" : 2426, "maxY" : 2528, "prop" : { "x" : 104, "y" : 2432, "width" : 89, "height" : 39 }, "textPosition" : { "x" : 111, "y" : 2436 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 193, "y" : 2432 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 193, "y" : 2432 } } }, "connectors" : [ { "edgeId" : 105486, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105490, "type" : "INPUT", "segments" : [ { "from" : { "x" : 150, "y" : 2474 }, "to" : { "x" : 155, "y" : 2504 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105490, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 163, "y" : 2474 }, "to" : { "x" : 185, "y" : 2498 } }, { "from" : { "x" : 185, "y" : 2498 }, "to" : { "x" : 168, "y" : 2521 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 165, "y" : 2524 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 165, "y" : 2524 } } } ] }, { "id" : 105488, "reactomeId" : 10894333, "displayName" : "SKP1:CUL1:RBX1:FBXL7", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 127, "y" : 2281 }, "minX" : 53, "maxX" : 188, "minY" : 2258, "maxY" : 2562, "prop" : { "x" : 80, "y" : 2264, "width" : 95, "height" : 35 }, "textPosition" : { "x" : 88, "y" : 2264 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 175, "y" : 2264 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 175, "y" : 2264 } } }, "connectors" : [ { "edgeId" : 105486, "type" : "INPUT", "segments" : [ { "from" : { "x" : 138, "y" : 2302 }, "to" : { "x" : 188, "y" : 2378 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105493, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 113, "y" : 2302 }, "to" : { "x" : 66, "y" : 2363 } }, { "from" : { "x" : 66, "y" : 2363 }, "to" : { "x" : 53, "y" : 2562 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 112, "y" : 2310 }, "b" : { "x" : 113, "y" : 2302 }, "c" : { "x" : 106, "y" : 2305 }, "type" : "ARROW", "centre" : { "x" : 106, "y" : 2305 } } }, { "edgeId" : 105495, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105491, "reactomeId" : 10829864, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 111, "y" : 2544 }, "minX" : 53, "maxX" : 155, "minY" : 2504, "maxY" : 2562, "prop" : { "x" : 93, "y" : 2529, "width" : 37, "height" : 31 }, "textPosition" : { "x" : 99, "y" : 2534 }, "connectors" : [ { "edgeId" : 105490, "type" : "INPUT", "segments" : [ { "from" : { "x" : 128, "y" : 2523 }, "to" : { "x" : 155, "y" : 2504 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 135, "y" : 2507 }, "b" : { "x" : 147, "y" : 2519 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 141, "y" : 2513 } } } }, { "edgeId" : 105493, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 87, "y" : 2549 }, "to" : { "x" : 53, "y" : 2562 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 64, "y" : 2549 }, "b" : { "x" : 76, "y" : 2561 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 70, "y" : 2555 } } }, "endShape" : { "a" : { "x" : 82, "y" : 2555 }, "b" : { "x" : 87, "y" : 2549 }, "c" : { "x" : 79, "y" : 2548 }, "type" : "ARROW", "centre" : { "x" : 79, "y" : 2548 } } } ] }, { "id" : 105492, "reactomeId" : 10894421, "displayName" : "SCF-FBXL7:PolyUb-AURKA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 154, "y" : 2624 }, "minX" : 101, "maxX" : 214, "minY" : 2598, "maxY" : 2644, "prop" : { "x" : 101, "y" : 2604, "width" : 107, "height" : 40 }, "textPosition" : { "x" : 107, "y" : 2609 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 208, "y" : 2604 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 208, "y" : 2604 } } }, "connectors" : [ { "edgeId" : 105490, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105493, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105494, "reactomeId" : 10829964, "displayName" : "26S proteasome", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 410, "y" : 2740 }, "minX" : 143, "maxX" : 529, "minY" : 2723, "maxY" : 2902, "prop" : { "x" : 354, "y" : 2729, "width" : 113, "height" : 22 }, "textPosition" : { "x" : 354, "y" : 2730 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 467, "y" : 2729 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 467, "y" : 2729 } } }, "connectors" : [ { "edgeId" : 105493, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 351, "y" : 2740 }, "to" : { "x" : 151, "y" : 2744 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 147, "y" : 2744 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 147, "y" : 2744 } } }, { "edgeId" : 105504, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 470, "y" : 2740 }, "to" : { "x" : 528, "y" : 2740 } }, { "from" : { "x" : 528, "y" : 2740 }, "to" : { "x" : 525, "y" : 2894 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 525, "y" : 2898 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 525, "y" : 2898 } } } ] }, { "id" : 105497, "reactomeId" : 10840272, "displayName" : "SkpA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 131, "y" : 2946 }, "minX" : 47, "maxX" : 160, "minY" : 2873, "maxY" : 2957, "prop" : { "x" : 108, "y" : 2935, "width" : 46, "height" : 22 }, "textPosition" : { "x" : 111, "y" : 2935 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 154, "y" : 2935 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 154, "y" : 2935 } } }, "connectors" : [ { "edgeId" : 105495, "type" : "INPUT", "segments" : [ { "from" : { "x" : 118, "y" : 2932 }, "to" : { "x" : 47, "y" : 2873 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105496, "reactomeId" : 10840274, "displayName" : "Cul1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 211, "y" : 2944 }, "minX" : 47, "maxX" : 240, "minY" : 2873, "maxY" : 2955, "prop" : { "x" : 189, "y" : 2934, "width" : 45, "height" : 21 }, "textPosition" : { "x" : 194, "y" : 2934 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 234, "y" : 2934 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 234, "y" : 2934 } } }, "connectors" : [ { "edgeId" : 105495, "type" : "INPUT", "segments" : [ { "from" : { "x" : 186, "y" : 2934 }, "to" : { "x" : 47, "y" : 2873 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105499, "reactomeId" : 10845353, "displayName" : "RBX1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 54, "y" : 2923 }, "minX" : 32, "maxX" : 82, "minY" : 2873, "maxY" : 2935, "prop" : { "x" : 32, "y" : 2911, "width" : 44, "height" : 24 }, "textPosition" : { "x" : 34, "y" : 2912 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 76, "y" : 2911 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 76, "y" : 2911 } } }, "connectors" : [ { "edgeId" : 105495, "type" : "INPUT", "segments" : [ { "from" : { "x" : 52, "y" : 2908 }, "to" : { "x" : 47, "y" : 2873 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105498, "reactomeId" : 10859227, "displayName" : "Fbxl7", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 187, "y" : 2872 }, "minX" : 47, "maxX" : 256, "minY" : 2855, "maxY" : 2884, "prop" : { "x" : 161, "y" : 2861, "width" : 53, "height" : 23 }, "textPosition" : { "x" : 167, "y" : 2862 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 214, "y" : 2861 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 214, "y" : 2861 } } }, "connectors" : [ { "edgeId" : 105495, "type" : "INPUT", "segments" : [ { "from" : { "x" : 158, "y" : 2872 }, "to" : { "x" : 47, "y" : 2873 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105500, "type" : "INPUT", "segments" : [ { "from" : { "x" : 217, "y" : 2872 }, "to" : { "x" : 256, "y" : 2872 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105501, "reactomeId" : 10829864, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 385, "y" : 2944 }, "minX" : 256, "maxX" : 478, "minY" : 2872, "maxY" : 2959, "prop" : { "x" : 356, "y" : 2929, "width" : 58, "height" : 30 }, "textPosition" : { "x" : 372, "y" : 2933 }, "connectors" : [ { "edgeId" : 105500, "type" : "INPUT", "segments" : [ { "from" : { "x" : 358, "y" : 2923 }, "to" : { "x" : 256, "y" : 2872 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 301, "y" : 2891 }, "b" : { "x" : 313, "y" : 2903 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 307, "y" : 2897 } } } }, { "edgeId" : 105504, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 466, "y" : 2917 }, "b" : { "x" : 478, "y" : 2929 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 472, "y" : 2923 } } } } ] }, { "id" : 105503, "reactomeId" : 10894433, "displayName" : "SKP1:CUL1:RBX1:FBXL18", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 293, "y" : 2814 }, "minX" : 234, "maxX" : 358, "minY" : 2790, "maxY" : 2864, "prop" : { "x" : 234, "y" : 2796, "width" : 118, "height" : 37 }, "textPosition" : { "x" : 236, "y" : 2798 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 352, "y" : 2796 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 352, "y" : 2796 } } }, "connectors" : [ { "edgeId" : 105500, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 293, "y" : 2836 }, "to" : { "x" : 294, "y" : 2856 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 294, "y" : 2860 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 294, "y" : 2860 } } } ] }, { "id" : 105502, "reactomeId" : 10894429, "displayName" : "Fbxl7", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 415, "y" : 2872 }, "minX" : 346, "maxX" : 491, "minY" : 2847, "maxY" : 2891, "prop" : { "x" : 346, "y" : 2853, "width" : 139, "height" : 38 }, "textPosition" : { "x" : 395, "y" : 2861 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 485, "y" : 2853 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 485, "y" : 2853 } } }, "connectors" : [ { "edgeId" : 105500, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105504, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105507, "reactomeId" : 77087, "displayName" : "AdoMet", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 586, "y" : 1581 }, "minX" : 527, "maxX" : 617, "minY" : 1565, "maxY" : 1600, "prop" : { "x" : 557, "y" : 1566, "width" : 59, "height" : 30 }, "textPosition" : { "x" : 559, "y" : 1570 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 611, "y" : 1571 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 611, "y" : 1571 } } }, "connectors" : [ { "edgeId" : 105505, "type" : "INPUT", "segments" : [ { "from" : { "x" : 554, "y" : 1590 }, "to" : { "x" : 527, "y" : 1600 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105506, "reactomeId" : 10862064, "displayName" : "PP2A", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 542, "y" : 1509 }, "minX" : 487, "maxX" : 570, "minY" : 1492, "maxY" : 1600, "prop" : { "x" : 520, "y" : 1498, "width" : 44, "height" : 22 }, "textPosition" : { "x" : 522, "y" : 1499 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 564, "y" : 1498 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 564, "y" : 1498 } } }, "connectors" : [ { "edgeId" : 105505, "type" : "INPUT", "segments" : [ { "from" : { "x" : 540, "y" : 1523 }, "to" : { "x" : 527, "y" : 1600 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105511, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 533, "y" : 1523 }, "to" : { "x" : 487, "y" : 1583 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 532, "y" : 1531 }, "b" : { "x" : 533, "y" : 1523 }, "c" : { "x" : 526, "y" : 1526 }, "type" : "ARROW", "centre" : { "x" : 526, "y" : 1526 } } } ] }, { "id" : 105509, "reactomeId" : 77502, "displayName" : "AdoHcy", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 584, "y" : 1692 }, "minX" : 527, "maxX" : 615, "minY" : 1655, "maxY" : 1707, "prop" : { "x" : 555, "y" : 1677, "width" : 59, "height" : 30 }, "textPosition" : { "x" : 557, "y" : 1681 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 609, "y" : 1682 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 609, "y" : 1682 } } }, "connectors" : [ { "edgeId" : 105505, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 560, "y" : 1674 }, "to" : { "x" : 527, "y" : 1655 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 552, "y" : 1674 }, "b" : { "x" : 560, "y" : 1674 }, "c" : { "x" : 556, "y" : 1667 }, "type" : "ARROW", "centre" : { "x" : 556, "y" : 1667 } } } ] }, { "id" : 105508, "reactomeId" : 10894804, "displayName" : "MeL-PP2A", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 529, "y" : 1739 }, "minX" : 488, "maxX" : 572, "minY" : 1655, "maxY" : 1750, "prop" : { "x" : 493, "y" : 1728, "width" : 73, "height" : 22 }, "textPosition" : { "x" : 495, "y" : 1729 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 566, "y" : 1728 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 566, "y" : 1728 } } }, "connectors" : [ { "edgeId" : 105505, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 528, "y" : 1725 }, "to" : { "x" : 527, "y" : 1655 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 524, "y" : 1718 }, "b" : { "x" : 528, "y" : 1725 }, "c" : { "x" : 532, "y" : 1718 }, "type" : "ARROW", "centre" : { "x" : 532, "y" : 1718 } } }, { "edgeId" : 105511, "type" : "INPUT", "segments" : [ { "from" : { "x" : 520, "y" : 1725 }, "to" : { "x" : 488, "y" : 1687 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105510, "reactomeId" : 10894809, "displayName" : "LCMT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 597, "y" : 1630 }, "minX" : 535, "maxX" : 635, "minY" : 1613, "maxY" : 1641, "prop" : { "x" : 565, "y" : 1619, "width" : 64, "height" : 22 }, "textPosition" : { "x" : 573, "y" : 1619 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 629, "y" : 1619 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 629, "y" : 1619 } } }, "connectors" : [ { "edgeId" : 105505, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 562, "y" : 1629 }, "to" : { "x" : 543, "y" : 1629 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 539, "y" : 1629 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 539, "y" : 1629 } } } ] }, { "id" : 105513, "reactomeId" : 8857797, "displayName" : "methanol", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 454, "y" : 1512 }, "minX" : 421, "maxX" : 489, "minY" : 1496, "maxY" : 1583, "prop" : { "x" : 421, "y" : 1497, "width" : 67, "height" : 30 }, "textPosition" : { "x" : 421, "y" : 1501 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 483, "y" : 1502 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 483, "y" : 1502 } } }, "connectors" : [ { "edgeId" : 105511, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 460, "y" : 1530 }, "to" : { "x" : 487, "y" : 1583 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 467, "y" : 1534 }, "b" : { "x" : 460, "y" : 1530 }, "c" : { "x" : 460, "y" : 1538 }, "type" : "ARROW", "centre" : { "x" : 460, "y" : 1538 } } } ] }, { "id" : 105512, "reactomeId" : 113518, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 445, "y" : 1735 }, "minX" : 425, "maxX" : 488, "minY" : 1687, "maxY" : 1750, "prop" : { "x" : 425, "y" : 1720, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 428, "y" : 1724 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 461, "y" : 1725 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 461, "y" : 1725 } } }, "connectors" : [ { "edgeId" : 105511, "type" : "INPUT", "segments" : [ { "from" : { "x" : 458, "y" : 1717 }, "to" : { "x" : 488, "y" : 1687 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 105514, "reactomeId" : 10894817, "displayName" : "Dmel\\CG5068", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 428, "y" : 1629 }, "minX" : 401, "maxX" : 478, "minY" : 1612, "maxY" : 1641, "prop" : { "x" : 401, "y" : 1618, "width" : 54, "height" : 23 }, "textPosition" : { "x" : 402, "y" : 1612 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 455, "y" : 1618 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 455, "y" : 1618 } } }, "connectors" : [ { "edgeId" : 105511, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 458, "y" : 1628 }, "to" : { "x" : 470, "y" : 1628 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 474, "y" : 1628 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 474, "y" : 1628 } } } ] }, { "id" : 105517, "reactomeId" : 10839762, "displayName" : "CCNA2:CDK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 281, "y" : 1128 }, "minX" : 254, "maxX" : 314, "minY" : 1104, "maxY" : 1147, "prop" : { "x" : 254, "y" : 1110, "width" : 54, "height" : 37 }, "textPosition" : { "x" : 254, "y" : 1112 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 308, "y" : 1110 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 308, "y" : 1110 } } }, "connectors" : [ { "edgeId" : 105515, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105516, "reactomeId" : 10839750, "displayName" : "CycA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 274, "y" : 1187 }, "minX" : 209, "maxX" : 305, "minY" : 1167, "maxY" : 1201, "prop" : { "x" : 249, "y" : 1173, "width" : 50, "height" : 28 }, "textPosition" : { "x" : 255, "y" : 1176 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 299, "y" : 1173 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 299, "y" : 1173 } } }, "connectors" : [ { "edgeId" : 105515, "type" : "INPUT", "segments" : [ { "from" : { "x" : 246, "y" : 1187 }, "to" : { "x" : 209, "y" : 1189 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105519, "reactomeId" : 10839754, "displayName" : "CycA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 108, "y" : 1238 }, "minX" : 83, "maxX" : 167, "minY" : 1185, "maxY" : 1251, "prop" : { "x" : 83, "y" : 1226, "width" : 51, "height" : 25 }, "textPosition" : { "x" : 90, "y" : 1228 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 134, "y" : 1226 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 134, "y" : 1226 } } }, "connectors" : [ { "edgeId" : 105518, "type" : "INPUT", "segments" : [ { "from" : { "x" : 121, "y" : 1223 }, "to" : { "x" : 167, "y" : 1185 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105520, "reactomeId" : 10839764, "displayName" : "CCNA1:CDK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 99, "y" : 1165 }, "minX" : 73, "maxX" : 131, "minY" : 1141, "maxY" : 1183, "prop" : { "x" : 73, "y" : 1147, "width" : 52, "height" : 36 }, "textPosition" : { "x" : 74, "y" : 1148 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 125, "y" : 1147 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 125, "y" : 1147 } } }, "connectors" : [ { "edgeId" : 105518, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105523, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1426, "y" : 758 }, "minX" : 1369, "maxX" : 1445, "minY" : 744, "maxY" : 772, "prop" : { "x" : 1408, "y" : 745, "width" : 36, "height" : 27 }, "textPosition" : { "x" : 1409, "y" : 748 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1439, "y" : 750 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1439, "y" : 750 } } }, "connectors" : [ { "edgeId" : 105521, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1405, "y" : 755 }, "to" : { "x" : 1369, "y" : 750 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1398, "y" : 758 }, "b" : { "x" : 1405, "y" : 755 }, "c" : { "x" : 1399, "y" : 750 }, "type" : "ARROW", "centre" : { "x" : 1399, "y" : 750 } } } ] }, { "id" : 105522, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1424, "y" : 832 }, "minX" : 1368, "maxX" : 1443, "minY" : 820, "maxY" : 844, "prop" : { "x" : 1407, "y" : 821, "width" : 35, "height" : 23 }, "textPosition" : { "x" : 1409, "y" : 822 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1437, "y" : 826 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1437, "y" : 826 } } }, "connectors" : [ { "edgeId" : 105521, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1404, "y" : 833 }, "to" : { "x" : 1368, "y" : 837 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105525, "reactomeId" : 10909324, "displayName" : "p-S-CCNA:p-T161-CDK1", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2108, "y" : 2489 }, "minX" : 925, "maxX" : 2189, "minY" : 2074, "maxY" : 2537, "prop" : { "x" : 2027, "y" : 2477, "width" : 162, "height" : 25 }, "textPosition" : { "x" : 2034, "y" : 2479 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 105524, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105529, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2021, "y" : 2493 }, "to" : { "x" : 1245, "y" : 2537 } }, { "from" : { "x" : 1245, "y" : 2537 }, "to" : { "x" : 955, "y" : 2080 } }, { "from" : { "x" : 955, "y" : 2080 }, "to" : { "x" : 933, "y" : 2078 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 929, "y" : 2078 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 929, "y" : 2078 } } } ] }, { "id" : 105527, "reactomeId" : 10909333, "displayName" : "phospho-p-T187,T190-WEE1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1105, "y" : 688 }, "minX" : 1037, "maxX" : 1209, "minY" : 667, "maxY" : 732, "prop" : { "x" : 1037, "y" : 673, "width" : 137, "height" : 31 }, "textPosition" : { "x" : 1048, "y" : 671 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1174, "y" : 673 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1174, "y" : 673 } } }, "connectors" : [ { "edgeId" : 105526, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1141, "y" : 707 }, "to" : { "x" : 1209, "y" : 732 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1149, "y" : 706 }, "b" : { "x" : 1141, "y" : 707 }, "c" : { "x" : 1146, "y" : 713 }, "type" : "ARROW", "centre" : { "x" : 1146, "y" : 713 } } } ] }, { "id" : 105528, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1218, "y" : 649 }, "minX" : 1197, "maxX" : 1241, "minY" : 634, "maxY" : 732, "prop" : { "x" : 1197, "y" : 635, "width" : 43, "height" : 29 }, "textPosition" : { "x" : 1202, "y" : 639 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1235, "y" : 640 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1235, "y" : 640 } } }, "connectors" : [ { "edgeId" : 105526, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1216, "y" : 667 }, "to" : { "x" : 1209, "y" : 732 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1206, "y" : 693 }, "b" : { "x" : 1218, "y" : 705 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1212, "y" : 699 } } }, "endShape" : { "a" : { "x" : 1219, "y" : 674 }, "b" : { "x" : 1216, "y" : 667 }, "c" : { "x" : 1211, "y" : 673 }, "type" : "ARROW", "centre" : { "x" : 1211, "y" : 673 } } } ] }, { "id" : 105531, "reactomeId" : 10840157, "displayName" : "fzr", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1719, "y" : 760 }, "minX" : 1696, "maxX" : 1780, "minY" : 743, "maxY" : 772, "prop" : { "x" : 1696, "y" : 749, "width" : 47, "height" : 23 }, "textPosition" : { "x" : 1708, "y" : 750 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1743, "y" : 749 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1743, "y" : 749 } } }, "connectors" : [ { "edgeId" : 105530, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1746, "y" : 760 }, "to" : { "x" : 1780, "y" : 761 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105533, "reactomeId" : 10909339, "displayName" : "phospho-fzr", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1986, "y" : 771 }, "minX" : 1862, "maxX" : 2040, "minY" : 754, "maxY" : 783, "prop" : { "x" : 1938, "y" : 760, "width" : 96, "height" : 23 }, "textPosition" : { "x" : 1945, "y" : 761 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2034, "y" : 760 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2034, "y" : 760 } } }, "connectors" : [ { "edgeId" : 105530, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1935, "y" : 768 }, "to" : { "x" : 1862, "y" : 765 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1928, "y" : 772 }, "b" : { "x" : 1935, "y" : 768 }, "c" : { "x" : 1928, "y" : 764 }, "type" : "ARROW", "centre" : { "x" : 1928, "y" : 764 } } } ] }, { "id" : 105532, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1759, "y" : 813 }, "minX" : 1738, "maxX" : 1782, "minY" : 761, "maxY" : 826, "prop" : { "x" : 1738, "y" : 801, "width" : 43, "height" : 25 }, "textPosition" : { "x" : 1744, "y" : 803 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1776, "y" : 806 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1776, "y" : 806 } } }, "connectors" : [ { "edgeId" : 105530, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1764, "y" : 798 }, "to" : { "x" : 1780, "y" : 761 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105534, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1916, "y" : 810 }, "minX" : 1862, "maxX" : 1937, "minY" : 765, "maxY" : 823, "prop" : { "x" : 1897, "y" : 798, "width" : 39, "height" : 25 }, "textPosition" : { "x" : 1900, "y" : 800 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1931, "y" : 803 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1931, "y" : 803 } } }, "connectors" : [ { "edgeId" : 105530, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1901, "y" : 795 }, "to" : { "x" : 1862, "y" : 765 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1893, "y" : 794 }, "b" : { "x" : 1901, "y" : 795 }, "c" : { "x" : 1898, "y" : 788 }, "type" : "ARROW", "centre" : { "x" : 1898, "y" : 788 } } } ] }, { "id" : 105537, "reactomeId" : 10839770, "displayName" : "stg", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1204, "y" : 394 }, "minX" : 1168, "maxX" : 1277, "minY" : 372, "maxY" : 410, "prop" : { "x" : 1168, "y" : 378, "width" : 72, "height" : 32 }, "textPosition" : { "x" : 1190, "y" : 383 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1240, "y" : 378 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1240, "y" : 378 } } }, "connectors" : [ { "edgeId" : 105535, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1243, "y" : 384 }, "to" : { "x" : 1277, "y" : 374 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105536, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1234, "y" : 323 }, "minX" : 1216, "maxX" : 1277, "minY" : 311, "maxY" : 374, "prop" : { "x" : 1216, "y" : 312, "width" : 36, "height" : 23 }, "textPosition" : { "x" : 1218, "y" : 313 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1247, "y" : 317 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1247, "y" : 317 } } }, "connectors" : [ { "edgeId" : 105535, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1243, "y" : 338 }, "to" : { "x" : 1277, "y" : 374 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105539, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1387, "y" : 330 }, "minX" : 1365, "maxX" : 1406, "minY" : 319, "maxY" : 389, "prop" : { "x" : 1370, "y" : 320, "width" : 35, "height" : 21 }, "textPosition" : { "x" : 1371, "y" : 320 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1400, "y" : 325 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1400, "y" : 325 } } }, "connectors" : [ { "edgeId" : 105535, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1383, "y" : 344 }, "to" : { "x" : 1365, "y" : 389 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1384, "y" : 352 }, "b" : { "x" : 1383, "y" : 344 }, "c" : { "x" : 1377, "y" : 349 }, "type" : "ARROW", "centre" : { "x" : 1377, "y" : 349 } } } ] }, { "id" : 105538, "reactomeId" : 10909344, "displayName" : "phospho-stg", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1454, "y" : 394 }, "minX" : 1365, "maxX" : 1506, "minY" : 375, "maxY" : 408, "prop" : { "x" : 1409, "y" : 381, "width" : 91, "height" : 27 }, "textPosition" : { "x" : 1411, "y" : 384 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1500, "y" : 381 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1500, "y" : 381 } } }, "connectors" : [ { "edgeId" : 105535, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1406, "y" : 391 }, "to" : { "x" : 1365, "y" : 389 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1399, "y" : 395 }, "b" : { "x" : 1406, "y" : 391 }, "c" : { "x" : 1399, "y" : 387 }, "type" : "ARROW", "centre" : { "x" : 1399, "y" : 387 } } } ] }, { "id" : 105542, "reactomeId" : 10839778, "displayName" : "PLK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 878, "y" : 2341 }, "minX" : 860, "maxX" : 903, "minY" : 2324, "maxY" : 2352, "prop" : { "x" : 860, "y" : 2330, "width" : 37, "height" : 22 }, "textPosition" : { "x" : 860, "y" : 2330 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 897, "y" : 2330 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 897, "y" : 2330 } } }, "connectors" : [ ] }, { "id" : 105564, "reactomeId" : 10872783, "displayName" : "PolyUb-TP53 Tetramer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1722, "y" : 1493 }, "minX" : 1675, "maxX" : 1776, "minY" : 1469, "maxY" : 1511, "prop" : { "x" : 1675, "y" : 1475, "width" : 95, "height" : 36 }, "textPosition" : { "x" : 1678, "y" : 1476 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1770, "y" : 1475 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1770, "y" : 1475 } } }, "connectors" : [ ] }, { "id" : 105567, "reactomeId" : 10910570, "displayName" : "Transcriptional Regulation by TP53", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2102, "y" : 2185 }, "minX" : 2030, "maxX" : 2175, "minY" : 2157, "maxY" : 2213, "prop" : { "x" : 2030, "y" : 2157, "width" : 145, "height" : 56 }, "textPosition" : { "x" : 2034, "y" : 2163 }, "connectors" : [ ] }, { "id" : 105572, "reactomeId" : 10839693, "displayName" : "CycB", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 298, "y" : 1793 }, "minX" : 273, "maxX" : 329, "minY" : 1776, "maxY" : 1804, "prop" : { "x" : 273, "y" : 1782, "width" : 50, "height" : 22 }, "textPosition" : { "x" : 279, "y" : 1782 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 323, "y" : 1782 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 323, "y" : 1782 } } }, "connectors" : [ ] }, { "id" : 105581, "reactomeId" : 10910540, "displayName" : "Mitotic G1 phase and G1/S transition", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1266, "y" : 1393 }, "minX" : 1171, "maxX" : 1361, "minY" : 1365, "maxY" : 1421, "prop" : { "x" : 1171, "y" : 1365, "width" : 190, "height" : 56 }, "textPosition" : { "x" : 1173, "y" : 1371 }, "connectors" : [ ] }, { "id" : 105361, "reactomeId" : 10839766, "displayName" : "CCNA:CDK1", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 183, "y" : 1126 }, "minX" : 140, "maxX" : 227, "minY" : 1087, "maxY" : 1137, "prop" : { "x" : 140, "y" : 1115, "width" : 87, "height" : 22 }, "textPosition" : { "x" : 145, "y" : 1115 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 105359, "type" : "INPUT", "segments" : [ { "from" : { "x" : 182, "y" : 1109 }, "to" : { "x" : 182, "y" : 1087 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105360, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 104, "y" : 1114 }, "minX" : 85, "maxX" : 182, "minY" : 1087, "maxY" : 1129, "prop" : { "x" : 85, "y" : 1099, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 88, "y" : 1103 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 118, "y" : 1104 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 118, "y" : 1104 } } }, "connectors" : [ { "edgeId" : 105359, "type" : "INPUT", "segments" : [ { "from" : { "x" : 126, "y" : 1107 }, "to" : { "x" : 182, "y" : 1087 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105363, "reactomeId" : 10839758, "displayName" : "CCNA:p-T14-CDK1", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 232, "y" : 999 }, "minX" : 170, "maxX" : 295, "minY" : 987, "maxY" : 1031, "prop" : { "x" : 170, "y" : 987, "width" : 125, "height" : 25 }, "textPosition" : { "x" : 174, "y" : 989 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 105359, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 212, "y" : 1018 }, "to" : { "x" : 181, "y" : 1031 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 207, "y" : 1024 }, "b" : { "x" : 212, "y" : 1018 }, "c" : { "x" : 204, "y" : 1017 }, "type" : "ARROW", "centre" : { "x" : 204, "y" : 1017 } } }, { "edgeId" : 105365, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105362, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 111, "y" : 1005 }, "minX" : 91, "maxX" : 181, "minY" : 989, "maxY" : 1031, "prop" : { "x" : 91, "y" : 990, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 94, "y" : 994 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 126, "y" : 995 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 126, "y" : 995 } } }, "connectors" : [ { "edgeId" : 105359, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 134, "y" : 1012 }, "to" : { "x" : 181, "y" : 1031 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 142, "y" : 1011 }, "b" : { "x" : 134, "y" : 1012 }, "c" : { "x" : 139, "y" : 1018 }, "type" : "ARROW", "centre" : { "x" : 139, "y" : 1018 } } } ] }, { "id" : 105364, "reactomeId" : 10839699, "displayName" : "PKMYT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 65, "y" : 1063 }, "minX" : 27, "maxX" : 191, "minY" : 1046, "maxY" : 1440, "prop" : { "x" : 27, "y" : 1052, "width" : 77, "height" : 22 }, "textPosition" : { "x" : 38, "y" : 1052 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 104, "y" : 1052 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 104, "y" : 1052 } } }, "connectors" : [ { "edgeId" : 105359, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 107, "y" : 1063 }, "to" : { "x" : 166, "y" : 1063 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 170, "y" : 1063 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 170, "y" : 1063 } } }, { "edgeId" : 105386, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 64, "y" : 1077 }, "to" : { "x" : 62, "y" : 1434 } }, { "from" : { "x" : 62, "y" : 1434 }, "to" : { "x" : 183, "y" : 1436 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 187, "y" : 1436 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 187, "y" : 1436 } } } ] }, { "id" : 105366, "reactomeId" : 10839740, "displayName" : "CCNA:p-T14-CDK1", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1053, "y" : 995 }, "minX" : 989, "maxX" : 1118, "minY" : 982, "maxY" : 1059, "prop" : { "x" : 989, "y" : 982, "width" : 129, "height" : 27 }, "textPosition" : { "x" : 995, "y" : 985 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 105365, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105367, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1064, "y" : 1015 }, "to" : { "x" : 1109, "y" : 1059 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105369, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1095, "y" : 1167 }, "minX" : 1075, "maxX" : 1116, "minY" : 1128, "maxY" : 1180, "prop" : { "x" : 1075, "y" : 1154, "width" : 40, "height" : 26 }, "textPosition" : { "x" : 1078, "y" : 1156 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1110, "y" : 1159 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1110, "y" : 1159 } } }, "connectors" : [ { "edgeId" : 105367, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1099, "y" : 1151 }, "to" : { "x" : 1109, "y" : 1128 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1098, "y" : 1143 }, "b" : { "x" : 1099, "y" : 1151 }, "c" : { "x" : 1105, "y" : 1146 }, "type" : "ARROW", "centre" : { "x" : 1105, "y" : 1146 } } } ] }, { "id" : 105368, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1141, "y" : 1027 }, "minX" : 1109, "maxX" : 1215, "minY" : 1011, "maxY" : 1059, "prop" : { "x" : 1122, "y" : 1012, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 1125, "y" : 1016 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1155, "y" : 1017 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1155, "y" : 1017 } } }, "connectors" : [ { "edgeId" : 105367, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1126, "y" : 1045 }, "to" : { "x" : 1109, "y" : 1059 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105526, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1163, "y" : 1034 }, "to" : { "x" : 1215, "y" : 1055 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1183, "y" : 1038 }, "b" : { "x" : 1195, "y" : 1050 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1189, "y" : 1044 } } } } ] }, { "id" : 105371, "reactomeId" : 10833143, "displayName" : "CAK", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1048, "y" : 1089 }, "minX" : 1031, "maxX" : 1101, "minY" : 1072, "maxY" : 1235, "prop" : { "x" : 1031, "y" : 1078, "width" : 34, "height" : 22 }, "textPosition" : { "x" : 1032, "y" : 1079 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1065, "y" : 1078 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1065, "y" : 1078 } } }, "connectors" : [ { "edgeId" : 105367, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1068, "y" : 1089 }, "to" : { "x" : 1093, "y" : 1089 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1097, "y" : 1089 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1097, "y" : 1089 } } }, { "edgeId" : 105393, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1049, "y" : 1103 }, "to" : { "x" : 1064, "y" : 1227 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1065, "y" : 1231 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1065, "y" : 1231 } } } ] }, { "id" : 105370, "reactomeId" : 10839746, "displayName" : "CCNA:p-T14,T161-CDK1", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1182, "y" : 1150 }, "minX" : 1109, "maxX" : 1243, "minY" : 1123, "maxY" : 1168, "prop" : { "x" : 1138, "y" : 1132, "width" : 88, "height" : 36 }, "textPosition" : { "x" : 1140, "y" : 1132 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 105367, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1132, "y" : 1136 }, "to" : { "x" : 1109, "y" : 1128 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1124, "y" : 1138 }, "b" : { "x" : 1132, "y" : 1136 }, "c" : { "x" : 1127, "y" : 1130 }, "type" : "ARROW", "centre" : { "x" : 1127, "y" : 1130 } } }, { "edgeId" : 105372, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1222, "y" : 1126 }, "to" : { "x" : 1243, "y" : 1123 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105373, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1287, "y" : 1145 }, "minX" : 1243, "maxX" : 1307, "minY" : 1123, "maxY" : 1160, "prop" : { "x" : 1268, "y" : 1130, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 1271, "y" : 1134 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1301, "y" : 1135 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1301, "y" : 1135 } } }, "connectors" : [ { "edgeId" : 105372, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1265, "y" : 1135 }, "to" : { "x" : 1243, "y" : 1123 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105375, "reactomeId" : 10839806, "displayName" : "CCNA:p-T14,Y15,T161-CDK1", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1297, "y" : 979 }, "minX" : 1240, "maxX" : 1430, "minY" : 962, "maxY" : 1055, "prop" : { "x" : 1240, "y" : 962, "width" : 115, "height" : 35 }, "textPosition" : { "x" : 1242, "y" : 962 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 105372, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1284, "y" : 1003 }, "to" : { "x" : 1243, "y" : 1055 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1283, "y" : 1011 }, "b" : { "x" : 1284, "y" : 1003 }, "c" : { "x" : 1277, "y" : 1006 }, "type" : "ARROW", "centre" : { "x" : 1277, "y" : 1006 } } }, { "edgeId" : 105377, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1361, "y" : 992 }, "to" : { "x" : 1430, "y" : 1011 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105374, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1336, "y" : 1027 }, "minX" : 1243, "maxX" : 1357, "minY" : 1011, "maxY" : 1055, "prop" : { "x" : 1316, "y" : 1012, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1319, "y" : 1016 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1351, "y" : 1017 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1351, "y" : 1017 } } }, "connectors" : [ { "edgeId" : 105372, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1313, "y" : 1033 }, "to" : { "x" : 1243, "y" : 1055 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1308, "y" : 1039 }, "b" : { "x" : 1313, "y" : 1033 }, "c" : { "x" : 1305, "y" : 1031 }, "type" : "ARROW", "centre" : { "x" : 1305, "y" : 1031 } } } ] }, { "id" : 105376, "reactomeId" : 10830175, "displayName" : "WEE1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1344, "y" : 1088 }, "minX" : 1215, "maxX" : 1548, "minY" : 1055, "maxY" : 1223, "prop" : { "x" : 1318, "y" : 1075, "width" : 53, "height" : 27 }, "textPosition" : { "x" : 1323, "y" : 1078 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1371, "y" : 1075 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1371, "y" : 1075 } } }, "connectors" : [ { "edgeId" : 105429, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1374, "y" : 1099 }, "to" : { "x" : 1548, "y" : 1180 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105372, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1315, "y" : 1088 }, "to" : { "x" : 1259, "y" : 1089 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1255, "y" : 1089 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1255, "y" : 1089 } } }, { "edgeId" : 105398, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1344, "y" : 1105 }, "to" : { "x" : 1348, "y" : 1215 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1349, "y" : 1219 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1349, "y" : 1219 } } }, { "edgeId" : 105526, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1315, "y" : 1081 }, "to" : { "x" : 1215, "y" : 1055 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105379, "reactomeId" : 113550, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1507, "y" : 912 }, "minX" : 1430, "maxX" : 1653, "minY" : 896, "maxY" : 950, "prop" : { "x" : 1494, "y" : 897, "width" : 27, "height" : 30 }, "textPosition" : { "x" : 1498, "y" : 901 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1516, "y" : 902 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1516, "y" : 902 } } }, "connectors" : [ { "edgeId" : 105426, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1524, "y" : 915 }, "to" : { "x" : 1653, "y" : 947 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1582, "y" : 925 }, "b" : { "x" : 1594, "y" : 937 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1588, "y" : 931 } } }, "endShape" : { "a" : { "x" : 1532, "y" : 913 }, "b" : { "x" : 1524, "y" : 915 }, "c" : { "x" : 1530, "y" : 921 }, "type" : "ARROW", "centre" : { "x" : 1530, "y" : 921 } } }, { "edgeId" : 105377, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1491, "y" : 918 }, "to" : { "x" : 1430, "y" : 950 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1454, "y" : 928 }, "b" : { "x" : 1466, "y" : 940 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1460, "y" : 934 } } }, "endShape" : { "a" : { "x" : 1487, "y" : 925 }, "b" : { "x" : 1491, "y" : 918 }, "c" : { "x" : 1483, "y" : 918 }, "type" : "ARROW", "centre" : { "x" : 1483, "y" : 918 } } } ] }, { "id" : 105378, "reactomeId" : 113518, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1444, "y" : 1061 }, "minX" : 1424, "maxX" : 1465, "minY" : 1011, "maxY" : 1076, "prop" : { "x" : 1424, "y" : 1046, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1427, "y" : 1050 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1459, "y" : 1051 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1459, "y" : 1051 } } }, "connectors" : [ { "edgeId" : 105377, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1439, "y" : 1043 }, "to" : { "x" : 1430, "y" : 1011 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1428, "y" : 1021 }, "b" : { "x" : 1440, "y" : 1033 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1434, "y" : 1027 } } } } ], "trivial" : true }, { "id" : 105381, "reactomeId" : 10830196, "displayName" : "Homologues of CDC25A", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1447, "y" : 1540 }, "minX" : 1418, "maxX" : 1514, "minY" : 975, "maxY" : 1551, "prop" : { "x" : 1418, "y" : 1529, "width" : 58, "height" : 22 }, "textPosition" : { "x" : 1418, "y" : 1516 }, "connectors" : [ { "edgeId" : 105377, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1479, "y" : 1540 }, "to" : { "x" : 1514, "y" : 1541 } }, { "from" : { "x" : 1514, "y" : 1541 }, "to" : { "x" : 1502, "y" : 983 } }, { "from" : { "x" : 1502, "y" : 983 }, "to" : { "x" : 1447, "y" : 979 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1443, "y" : 979 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1443, "y" : 979 } } } ] }, { "id" : 105380, "reactomeId" : 10839814, "displayName" : "CCNA:p-T161-CDK1", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1360, "y" : 904 }, "minX" : 1291, "maxX" : 1430, "minY" : 803, "maxY" : 950, "prop" : { "x" : 1291, "y" : 893, "width" : 139, "height" : 23 }, "textPosition" : { "x" : 1298, "y" : 894 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 105377, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1377, "y" : 922 }, "to" : { "x" : 1430, "y" : 950 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1385, "y" : 922 }, "b" : { "x" : 1377, "y" : 922 }, "c" : { "x" : 1381, "y" : 929 }, "type" : "ARROW", "centre" : { "x" : 1381, "y" : 929 } } }, { "edgeId" : 105521, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1361, "y" : 887 }, "to" : { "x" : 1368, "y" : 837 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105521, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1351, "y" : 887 }, "to" : { "x" : 1311, "y" : 835 } }, { "from" : { "x" : 1311, "y" : 835 }, "to" : { "x" : 1353, "y" : 809 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1357, "y" : 807 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1357, "y" : 807 } } } ] }, { "id" : 105383, "reactomeId" : 10839654, "displayName" : "CycB", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 260, "y" : 1227 }, "minX" : 227, "maxX" : 293, "minY" : 1210, "maxY" : 1254, "prop" : { "x" : 233, "y" : 1216, "width" : 54, "height" : 22 }, "textPosition" : { "x" : 241, "y" : 1216 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 287, "y" : 1216 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 287, "y" : 1216 } } }, "connectors" : [ { "edgeId" : 105382, "type" : "INPUT", "segments" : [ { "from" : { "x" : 246, "y" : 1244 }, "to" : { "x" : 227, "y" : 1254 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105385, "reactomeId" : 10839697, "displayName" : "CCNB:CDK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 208, "y" : 1334 }, "minX" : 164, "maxX" : 258, "minY" : 1316, "maxY" : 1402, "prop" : { "x" : 164, "y" : 1322, "width" : 88, "height" : 25 }, "textPosition" : { "x" : 169, "y" : 1326 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 252, "y" : 1322 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 252, "y" : 1322 } } }, "connectors" : [ { "edgeId" : 105382, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105386, "type" : "INPUT", "segments" : [ { "from" : { "x" : 206, "y" : 1350 }, "to" : { "x" : 199, "y" : 1402 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105384, "reactomeId" : 10839695, "displayName" : "CDK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 193, "y" : 1228 }, "minX" : 167, "maxX" : 227, "minY" : 1185, "maxY" : 1254, "prop" : { "x" : 167, "y" : 1218, "width" : 52, "height" : 21 }, "textPosition" : { "x" : 173, "y" : 1218 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 219, "y" : 1218 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 219, "y" : 1218 } } }, "connectors" : [ { "edgeId" : 105382, "type" : "INPUT", "segments" : [ { "from" : { "x" : 206, "y" : 1242 }, "to" : { "x" : 227, "y" : 1254 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105515, "type" : "INPUT", "segments" : [ { "from" : { "x" : 197, "y" : 1215 }, "to" : { "x" : 209, "y" : 1189 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105518, "type" : "INPUT", "segments" : [ { "from" : { "x" : 186, "y" : 1215 }, "to" : { "x" : 167, "y" : 1185 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105387, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 148, "y" : 1371 }, "minX" : 129, "maxX" : 199, "minY" : 1355, "maxY" : 1402, "prop" : { "x" : 129, "y" : 1356, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 132, "y" : 1360 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 162, "y" : 1361 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 162, "y" : 1361 } } }, "connectors" : [ { "edgeId" : 105386, "type" : "INPUT", "segments" : [ { "from" : { "x" : 170, "y" : 1382 }, "to" : { "x" : 199, "y" : 1402 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105389, "reactomeId" : 10839656, "displayName" : "Cyclin B1:phospho-Cdc2 ( Thr 14)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 203, "y" : 1585 }, "minX" : 141, "maxX" : 271, "minY" : 1472, "maxY" : 1597, "prop" : { "x" : 141, "y" : 1574, "width" : 124, "height" : 23 }, "textPosition" : { "x" : 147, "y" : 1548 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 265, "y" : 1574 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 265, "y" : 1574 } } }, "connectors" : [ { "edgeId" : 105386, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 202, "y" : 1571 }, "to" : { "x" : 198, "y" : 1472 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 198, "y" : 1564 }, "b" : { "x" : 202, "y" : 1571 }, "c" : { "x" : 206, "y" : 1564 }, "type" : "ARROW", "centre" : { "x" : 206, "y" : 1564 } } } ] }, { "id" : 105388, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 141, "y" : 1518 }, "minX" : 121, "maxX" : 198, "minY" : 1472, "maxY" : 1533, "prop" : { "x" : 121, "y" : 1503, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 124, "y" : 1507 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 156, "y" : 1508 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 156, "y" : 1508 } } }, "connectors" : [ { "edgeId" : 105386, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 159, "y" : 1500 }, "to" : { "x" : 198, "y" : 1472 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 162, "y" : 1493 }, "b" : { "x" : 159, "y" : 1500 }, "c" : { "x" : 167, "y" : 1499 }, "type" : "ARROW", "centre" : { "x" : 167, "y" : 1499 } } } ] }, { "id" : 105391, "reactomeId" : 10839671, "displayName" : "cytoplasmic Cyclin B1:Cdc2 complexes", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1880, "y" : 1970 }, "minX" : 1821, "maxX" : 1939, "minY" : 1942, "maxY" : 1998, "prop" : { "x" : 1821, "y" : 1942, "width" : 118, "height" : 56 }, "textPosition" : { "x" : 1829, "y" : 1945 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 105390, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105392, "reactomeId" : 10839689, "displayName" : "nuclear Cyclin B1:Cdc2 complexes", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1843, "y" : 1682 }, "minX" : 1784, "maxX" : 1903, "minY" : 1664, "maxY" : 1700, "prop" : { "x" : 1784, "y" : 1664, "width" : 119, "height" : 36 }, "textPosition" : { "x" : 1784, "y" : 1664 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 105390, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105395, "reactomeId" : 10839677, "displayName" : "CCNB1:p-T14-CDK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 956, "y" : 1265 }, "minX" : 905, "maxX" : 1031, "minY" : 1241, "maxY" : 1283, "prop" : { "x" : 905, "y" : 1247, "width" : 103, "height" : 36 }, "textPosition" : { "x" : 910, "y" : 1248 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1008, "y" : 1247 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1008, "y" : 1247 } } }, "connectors" : [ { "edgeId" : 105393, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1011, "y" : 1251 }, "to" : { "x" : 1031, "y" : 1246 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105394, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 988, "y" : 1200 }, "minX" : 968, "maxX" : 1031, "minY" : 1186, "maxY" : 1246, "prop" : { "x" : 968, "y" : 1187, "width" : 41, "height" : 26 }, "textPosition" : { "x" : 973, "y" : 1189 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1004, "y" : 1192 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1004, "y" : 1192 } } }, "connectors" : [ { "edgeId" : 105393, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1000, "y" : 1216 }, "to" : { "x" : 1031, "y" : 1246 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105397, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1162, "y" : 1211 }, "minX" : 1138, "maxX" : 1183, "minY" : 1198, "maxY" : 1249, "prop" : { "x" : 1143, "y" : 1199, "width" : 39, "height" : 25 }, "textPosition" : { "x" : 1146, "y" : 1201 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1177, "y" : 1204 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1177, "y" : 1204 } } }, "connectors" : [ { "edgeId" : 105393, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1154, "y" : 1227 }, "to" : { "x" : 1138, "y" : 1249 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1153, "y" : 1235 }, "b" : { "x" : 1154, "y" : 1227 }, "c" : { "x" : 1147, "y" : 1230 }, "type" : "ARROW", "centre" : { "x" : 1147, "y" : 1230 } } } ] }, { "id" : 105396, "reactomeId" : 10839708, "displayName" : "CCNB1:p-T14,T161-CDK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1255, "y" : 1249 }, "minX" : 1138, "maxX" : 1325, "minY" : 1226, "maxY" : 1267, "prop" : { "x" : 1203, "y" : 1232, "width" : 105, "height" : 35 }, "textPosition" : { "x" : 1209, "y" : 1232 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1308, "y" : 1232 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1308, "y" : 1232 } } }, "connectors" : [ { "edgeId" : 105393, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1200, "y" : 1249 }, "to" : { "x" : 1138, "y" : 1249 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1193, "y" : 1253 }, "b" : { "x" : 1200, "y" : 1249 }, "c" : { "x" : 1193, "y" : 1245 }, "type" : "ARROW", "centre" : { "x" : 1193, "y" : 1245 } } }, { "edgeId" : 105398, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1311, "y" : 1235 }, "to" : { "x" : 1325, "y" : 1231 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105399, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1293, "y" : 1205 }, "minX" : 1274, "maxX" : 1325, "minY" : 1191, "maxY" : 1231, "prop" : { "x" : 1274, "y" : 1192, "width" : 38, "height" : 26 }, "textPosition" : { "x" : 1277, "y" : 1194 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1307, "y" : 1197 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1307, "y" : 1197 } } }, "connectors" : [ { "edgeId" : 105398, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1309, "y" : 1221 }, "to" : { "x" : 1325, "y" : 1231 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105401, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1414, "y" : 1207 }, "minX" : 1383, "maxX" : 1435, "minY" : 1195, "maxY" : 1241, "prop" : { "x" : 1395, "y" : 1196, "width" : 39, "height" : 23 }, "textPosition" : { "x" : 1398, "y" : 1197 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1429, "y" : 1201 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1429, "y" : 1201 } } }, "connectors" : [ { "edgeId" : 105398, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1403, "y" : 1222 }, "to" : { "x" : 1383, "y" : 1241 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1401, "y" : 1230 }, "b" : { "x" : 1403, "y" : 1222 }, "c" : { "x" : 1395, "y" : 1224 }, "type" : "ARROW", "centre" : { "x" : 1395, "y" : 1224 } } } ] }, { "id" : 105400, "reactomeId" : 10839681, "displayName" : "CCNB1:p-T14,Y15,T161-CDK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1410, "y" : 1308 }, "minX" : 1346, "maxX" : 1642, "minY" : 1054, "maxY" : 1326, "prop" : { "x" : 1346, "y" : 1290, "width" : 128, "height" : 36 }, "textPosition" : { "x" : 1350, "y" : 1291 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1474, "y" : 1290 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1474, "y" : 1290 } } }, "connectors" : [ { "edgeId" : 105426, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1426, "y" : 1287 }, "to" : { "x" : 1642, "y" : 1054 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105398, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1402, "y" : 1287 }, "to" : { "x" : 1383, "y" : 1241 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1396, "y" : 1282 }, "b" : { "x" : 1402, "y" : 1287 }, "c" : { "x" : 1403, "y" : 1279 }, "type" : "ARROW", "centre" : { "x" : 1403, "y" : 1279 } } }, { "edgeId" : 105403, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105402, "reactomeId" : 10839720, "displayName" : "p-S-CCNA:p-T161-CDK1", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1384, "y" : 669 }, "minX" : 1212, "maxX" : 1831, "minY" : 392, "maxY" : 1229, "prop" : { "x" : 1302, "y" : 656, "width" : 165, "height" : 27 }, "textPosition" : { "x" : 1310, "y" : 659 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 105521, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1381, "y" : 689 }, "to" : { "x" : 1369, "y" : 750 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1384, "y" : 697 }, "b" : { "x" : 1381, "y" : 689 }, "c" : { "x" : 1376, "y" : 695 }, "type" : "ARROW", "centre" : { "x" : 1376, "y" : 695 } } }, { "edgeId" : 105524, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105398, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1396, "y" : 689 }, "to" : { "x" : 1467, "y" : 760 } }, { "from" : { "x" : 1467, "y" : 760 }, "to" : { "x" : 1481, "y" : 1130 } }, { "from" : { "x" : 1481, "y" : 1130 }, "to" : { "x" : 1356, "y" : 1226 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1354, "y" : 1223 }, "b" : { "x" : 1358, "y" : 1229 }, "c" : { "x" : 1356, "y" : 1226 }, "type" : "STOP", "centre" : { "x" : 1356, "y" : 1226 } } }, { "edgeId" : 105526, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1369, "y" : 689 }, "to" : { "x" : 1219, "y" : 819 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1216, "y" : 822 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1216, "y" : 822 } } }, { "edgeId" : 105530, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1473, "y" : 679 }, "to" : { "x" : 1821, "y" : 723 } }, { "from" : { "x" : 1821, "y" : 723 }, "to" : { "x" : 1827, "y" : 748 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1827, "y" : 752 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1827, "y" : 752 } } }, { "edgeId" : 105535, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1381, "y" : 650 }, "to" : { "x" : 1331, "y" : 400 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1330, "y" : 396 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1330, "y" : 396 } } } ] }, { "id" : 105405, "reactomeId" : 10839728, "displayName" : "emb", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1555, "y" : 1715 }, "minX" : 1502, "maxX" : 1581, "minY" : 1698, "maxY" : 1731, "prop" : { "x" : 1535, "y" : 1704, "width" : 40, "height" : 22 }, "textPosition" : { "x" : 1537, "y" : 1704 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1575, "y" : 1704 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1575, "y" : 1704 } } }, "connectors" : [ { "edgeId" : 105403, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1532, "y" : 1720 }, "to" : { "x" : 1502, "y" : 1729 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1507, "y" : 1723 }, "b" : { "x" : 1502, "y" : 1729 }, "c" : { "x" : 1510, "y" : 1731 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1510, "y" : 1731 } } } ] }, { "id" : 105404, "reactomeId" : 10839661, "displayName" : "CCNB1:p-T14,Y15,T161-CDK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1468, "y" : 1933 }, "minX" : 1404, "maxX" : 1538, "minY" : 1909, "maxY" : 1951, "prop" : { "x" : 1404, "y" : 1915, "width" : 128, "height" : 36 }, "textPosition" : { "x" : 1408, "y" : 1916 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1532, "y" : 1915 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1532, "y" : 1915 } } }, "connectors" : [ { "edgeId" : 105403, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105407, "reactomeId" : 10839770, "displayName" : "stg", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1609, "y" : 1827 }, "minX" : 1573, "maxX" : 1651, "minY" : 1805, "maxY" : 1843, "prop" : { "x" : 1573, "y" : 1811, "width" : 72, "height" : 32 }, "textPosition" : { "x" : 1595, "y" : 1816 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1645, "y" : 1811 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1645, "y" : 1811 } } }, "connectors" : [ { "edgeId" : 105406, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105408, "reactomeId" : 10839772, "displayName" : "stg", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1574, "y" : 2165 }, "minX" : 1484, "maxX" : 1610, "minY" : 2145, "maxY" : 2179, "prop" : { "x" : 1544, "y" : 2151, "width" : 60, "height" : 28 }, "textPosition" : { "x" : 1560, "y" : 2154 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1604, "y" : 2151 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1604, "y" : 2151 } } }, "connectors" : [ { "edgeId" : 105409, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1541, "y" : 2166 }, "to" : { "x" : 1492, "y" : 2168 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1488, "y" : 2168 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1488, "y" : 2168 } } }, { "edgeId" : 105406, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105411, "reactomeId" : 10839830, "displayName" : "CCNB1,CCNB2:p-T14,Y15,T161-CDK1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1471, "y" : 2020 }, "minX" : 1414, "maxX" : 1529, "minY" : 1993, "maxY" : 2125, "prop" : { "x" : 1414, "y" : 1993, "width" : 115, "height" : 54 }, "textPosition" : { "x" : 1416, "y" : 1995 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 105409, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1471, "y" : 2053 }, "to" : { "x" : 1473, "y" : 2125 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105410, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1526, "y" : 2119 }, "minX" : 1473, "maxX" : 1545, "minY" : 2106, "maxY" : 2132, "prop" : { "x" : 1508, "y" : 2107, "width" : 36, "height" : 25 }, "textPosition" : { "x" : 1509, "y" : 2109 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1539, "y" : 2112 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1539, "y" : 2112 } } }, "connectors" : [ { "edgeId" : 105409, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1505, "y" : 2121 }, "to" : { "x" : 1473, "y" : 2125 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1483, "y" : 2117 }, "b" : { "x" : 1495, "y" : 2129 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1489, "y" : 2123 } } } } ], "trivial" : true }, { "id" : 105413, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1561, "y" : 2231 }, "minX" : 1506, "maxX" : 1579, "minY" : 2219, "maxY" : 2242, "prop" : { "x" : 1545, "y" : 2220, "width" : 33, "height" : 22 }, "textPosition" : { "x" : 1552, "y" : 2220 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1573, "y" : 2225 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1573, "y" : 2225 } } }, "connectors" : [ { "edgeId" : 105409, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1542, "y" : 2230 }, "to" : { "x" : 1506, "y" : 2230 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1518, "y" : 2224 }, "b" : { "x" : 1530, "y" : 2236 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1524, "y" : 2230 } } }, "endShape" : { "a" : { "x" : 1535, "y" : 2234 }, "b" : { "x" : 1542, "y" : 2230 }, "c" : { "x" : 1535, "y" : 2226 }, "type" : "ARROW", "centre" : { "x" : 1535, "y" : 2226 } } } ] }, { "id" : 105412, "reactomeId" : 10839834, "displayName" : "CCNB1,CCNB2:p-T161-CDK1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1477, "y" : 2282 }, "minX" : 900, "maxX" : 1527, "minY" : 2105, "maxY" : 2299, "prop" : { "x" : 1427, "y" : 2266, "width" : 100, "height" : 33 }, "textPosition" : { "x" : 1428, "y" : 2265 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 105409, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1486, "y" : 2260 }, "to" : { "x" : 1506, "y" : 2230 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1487, "y" : 2252 }, "b" : { "x" : 1486, "y" : 2260 }, "c" : { "x" : 1493, "y" : 2256 }, "type" : "ARROW", "centre" : { "x" : 1493, "y" : 2256 } } }, { "edgeId" : 105481, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1421, "y" : 2283 }, "to" : { "x" : 1044, "y" : 2295 } }, { "from" : { "x" : 1044, "y" : 2295 }, "to" : { "x" : 987, "y" : 2159 } }, { "from" : { "x" : 987, "y" : 2159 }, "to" : { "x" : 908, "y" : 2111 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 904, "y" : 2109 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 904, "y" : 2109 } } } ] }, { "id" : 105415, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1472, "y" : 2422 }, "minX" : 1414, "maxX" : 1492, "minY" : 2381, "maxY" : 2437, "prop" : { "x" : 1453, "y" : 2407, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 1456, "y" : 2411 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1486, "y" : 2412 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1486, "y" : 2412 } } }, "connectors" : [ { "edgeId" : 105414, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1450, "y" : 2408 }, "to" : { "x" : 1414, "y" : 2381 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1426, "y" : 2388 }, "b" : { "x" : 1438, "y" : 2400 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1432, "y" : 2394 } } } } ] }, { "id" : 105417, "reactomeId" : 10839669, "displayName" : "phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1259, "y" : 2340 }, "minX" : 1198, "maxX" : 1362, "minY" : 2309, "maxY" : 2380, "prop" : { "x" : 1198, "y" : 2315, "width" : 122, "height" : 50 }, "textPosition" : { "x" : 1198, "y" : 2316 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1320, "y" : 2315 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1320, "y" : 2315 } } }, "connectors" : [ { "edgeId" : 105414, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1323, "y" : 2363 }, "to" : { "x" : 1362, "y" : 2380 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1331, "y" : 2362 }, "b" : { "x" : 1323, "y" : 2363 }, "c" : { "x" : 1328, "y" : 2369 }, "type" : "ARROW", "centre" : { "x" : 1328, "y" : 2369 } } } ] }, { "id" : 105416, "reactomeId" : 10839776, "displayName" : "CCNB1:p-T161-CDK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1494, "y" : 2343 }, "minX" : 1414, "maxX" : 1558, "minY" : 2318, "maxY" : 2381, "prop" : { "x" : 1437, "y" : 2324, "width" : 115, "height" : 38 }, "textPosition" : { "x" : 1444, "y" : 2327 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1552, "y" : 2324 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1552, "y" : 2324 } } }, "connectors" : [ { "edgeId" : 105414, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1454, "y" : 2365 }, "to" : { "x" : 1414, "y" : 2381 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105419, "reactomeId" : 10839780, "displayName" : "CRS kinase", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1391, "y" : 2441 }, "minX" : 1356, "maxX" : 1426, "minY" : 2389, "maxY" : 2458, "prop" : { "x" : 1356, "y" : 2424, "width" : 70, "height" : 34 }, "textPosition" : { "x" : 1366, "y" : 2424 }, "connectors" : [ { "edgeId" : 105414, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1390, "y" : 2418 }, "to" : { "x" : 1390, "y" : 2397 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1390, "y" : 2393 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1390, "y" : 2393 } } } ] }, { "id" : 105418, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1301, "y" : 2404 }, "minX" : 1281, "maxX" : 1362, "minY" : 2380, "maxY" : 2419, "prop" : { "x" : 1281, "y" : 2389, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1284, "y" : 2393 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1316, "y" : 2394 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1316, "y" : 2394 } } }, "connectors" : [ { "edgeId" : 105414, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1324, "y" : 2396 }, "to" : { "x" : 1362, "y" : 2380 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1337, "y" : 2382 }, "b" : { "x" : 1349, "y" : 2394 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1343, "y" : 2388 } } }, "endShape" : { "a" : { "x" : 1329, "y" : 2390 }, "b" : { "x" : 1324, "y" : 2396 }, "c" : { "x" : 1332, "y" : 2397 }, "type" : "ARROW", "centre" : { "x" : 1332, "y" : 2397 } } } ] }, { "id" : 105421, "reactomeId" : 10839669, "displayName" : "phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2019, "y" : 1969 }, "minX" : 1962, "maxX" : 2083, "minY" : 1938, "maxY" : 1994, "prop" : { "x" : 1962, "y" : 1944, "width" : 115, "height" : 50 }, "textPosition" : { "x" : 1963, "y" : 1945 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2077, "y" : 1944 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2077, "y" : 1944 } } }, "connectors" : [ { "edgeId" : 105420, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105422, "reactomeId" : 10839687, "displayName" : "p-4S-CCNB1:p-T161-CDK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1986, "y" : 1683 }, "minX" : 1924, "maxX" : 2055, "minY" : 1652, "maxY" : 1708, "prop" : { "x" : 1924, "y" : 1658, "width" : 125, "height" : 50 }, "textPosition" : { "x" : 1938, "y" : 1673 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2049, "y" : 1658 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2049, "y" : 1658 } } }, "connectors" : [ { "edgeId" : 105420, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105425, "reactomeId" : 10839797, "displayName" : "CDC25", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1563, "y" : 974 }, "minX" : 1531, "maxX" : 1638, "minY" : 963, "maxY" : 986, "prop" : { "x" : 1531, "y" : 963, "width" : 64, "height" : 22 }, "textPosition" : { "x" : 1538, "y" : 963 }, "connectors" : [ { "edgeId" : 105423, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105426, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1601, "y" : 977 }, "to" : { "x" : 1630, "y" : 982 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1634, "y" : 982 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1634, "y" : 982 } } } ] }, { "id" : 105424, "reactomeId" : 10839824, "displayName" : "CDC25", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1664, "y" : 2109 }, "minX" : 1636, "maxX" : 1692, "minY" : 2098, "maxY" : 2120, "prop" : { "x" : 1636, "y" : 2098, "width" : 56, "height" : 22 }, "textPosition" : { "x" : 1639, "y" : 2098 }, "connectors" : [ { "edgeId" : 105423, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105427, "reactomeId" : 113518, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1710, "y" : 1055 }, "minX" : 1642, "maxX" : 1730, "minY" : 1040, "maxY" : 1069, "prop" : { "x" : 1691, "y" : 1041, "width" : 38, "height" : 28 }, "textPosition" : { "x" : 1693, "y" : 1044 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1724, "y" : 1046 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1724, "y" : 1046 } } }, "connectors" : [ { "edgeId" : 105426, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1688, "y" : 1054 }, "to" : { "x" : 1642, "y" : 1054 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1659, "y" : 1048 }, "b" : { "x" : 1671, "y" : 1060 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1665, "y" : 1054 } } } } ], "trivial" : true }, { "id" : 105428, "reactomeId" : 10839795, "displayName" : "CCNB1:p-T161-CDK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1698, "y" : 860 }, "minX" : 1644, "maxX" : 1758, "minY" : 836, "maxY" : 947, "prop" : { "x" : 1644, "y" : 842, "width" : 108, "height" : 36 }, "textPosition" : { "x" : 1648, "y" : 843 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1752, "y" : 842 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1752, "y" : 842 } } }, "connectors" : [ { "edgeId" : 105426, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1688, "y" : 881 }, "to" : { "x" : 1653, "y" : 947 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1688, "y" : 889 }, "b" : { "x" : 1688, "y" : 881 }, "c" : { "x" : 1681, "y" : 885 }, "type" : "ARROW", "centre" : { "x" : 1681, "y" : 885 } } } ] }, { "id" : 105431, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1760, "y" : 1314 }, "minX" : 1742, "maxX" : 1779, "minY" : 1260, "maxY" : 1326, "prop" : { "x" : 1742, "y" : 1302, "width" : 36, "height" : 24 }, "textPosition" : { "x" : 1743, "y" : 1303 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1773, "y" : 1307 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1773, "y" : 1307 } } }, "connectors" : [ { "edgeId" : 105429, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1757, "y" : 1299 }, "to" : { "x" : 1747, "y" : 1260 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1751, "y" : 1293 }, "b" : { "x" : 1757, "y" : 1299 }, "c" : { "x" : 1759, "y" : 1291 }, "type" : "ARROW", "centre" : { "x" : 1759, "y" : 1291 } } } ] }, { "id" : 105430, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1545, "y" : 1249 }, "minX" : 1527, "maxX" : 1564, "minY" : 1180, "maxY" : 1263, "prop" : { "x" : 1527, "y" : 1235, "width" : 36, "height" : 28 }, "textPosition" : { "x" : 1529, "y" : 1238 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1558, "y" : 1240 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1558, "y" : 1240 } } }, "connectors" : [ { "edgeId" : 105429, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1545, "y" : 1232 }, "to" : { "x" : 1548, "y" : 1180 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105433, "reactomeId" : 10837539, "displayName" : "phospho-p-T210-PLK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1721, "y" : 1208 }, "minX" : 1670, "maxX" : 1778, "minY" : 1162, "maxY" : 1252, "prop" : { "x" : 1670, "y" : 1196, "width" : 102, "height" : 24 }, "textPosition" : { "x" : 1681, "y" : 1191 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1772, "y" : 1196 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1772, "y" : 1196 } } }, "connectors" : [ { "edgeId" : 105429, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1721, "y" : 1223 }, "to" : { "x" : 1722, "y" : 1244 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1722, "y" : 1248 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1722, "y" : 1248 } } }, { "edgeId" : 105440, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1726, "y" : 1193 }, "to" : { "x" : 1738, "y" : 1169 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1740, "y" : 1166 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1740, "y" : 1166 } } } ] }, { "id" : 105432, "reactomeId" : 10837575, "displayName" : "phospho-p-S53-WEE1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1818, "y" : 1260 }, "minX" : 1747, "maxX" : 1866, "minY" : 1234, "maxY" : 1281, "prop" : { "x" : 1776, "y" : 1240, "width" : 84, "height" : 41 }, "textPosition" : { "x" : 1778, "y" : 1243 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1860, "y" : 1240 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1860, "y" : 1240 } } }, "connectors" : [ { "edgeId" : 105429, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1773, "y" : 1260 }, "to" : { "x" : 1747, "y" : 1260 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1766, "y" : 1264 }, "b" : { "x" : 1773, "y" : 1260 }, "c" : { "x" : 1766, "y" : 1256 }, "type" : "ARROW", "centre" : { "x" : 1766, "y" : 1256 } } } ] }, { "id" : 105435, "reactomeId" : 10837548, "displayName" : "Homologues of CDC25C", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1762, "y" : 2146 }, "minX" : 1731, "maxX" : 1793, "minY" : 2102, "maxY" : 2157, "prop" : { "x" : 1731, "y" : 2136, "width" : 62, "height" : 21 }, "textPosition" : { "x" : 1732, "y" : 2122 }, "connectors" : [ { "edgeId" : 105434, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1761, "y" : 2133 }, "to" : { "x" : 1758, "y" : 2102 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105437, "reactomeId" : 10837556, "displayName" : "Homologues of p-S198-CDC25C", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1751, "y" : 1917 }, "minX" : 1693, "maxX" : 1809, "minY" : 1906, "maxY" : 2021, "prop" : { "x" : 1693, "y" : 1906, "width" : 116, "height" : 22 }, "textPosition" : { "x" : 1698, "y" : 1900 }, "connectors" : [ { "edgeId" : 105434, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1750, "y" : 1931 }, "to" : { "x" : 1750, "y" : 2021 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1754, "y" : 1938 }, "b" : { "x" : 1750, "y" : 1931 }, "c" : { "x" : 1746, "y" : 1938 }, "type" : "ARROW", "centre" : { "x" : 1746, "y" : 1938 } } }, { "edgeId" : 105450, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105436, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1835, "y" : 2140 }, "minX" : 1758, "maxX" : 1853, "minY" : 2102, "maxY" : 2152, "prop" : { "x" : 1819, "y" : 2128, "width" : 33, "height" : 24 }, "textPosition" : { "x" : 1820, "y" : 2129 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1847, "y" : 2133 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1847, "y" : 2133 } } }, "connectors" : [ { "edgeId" : 105434, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1816, "y" : 2131 }, "to" : { "x" : 1758, "y" : 2102 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105439, "reactomeId" : 10837558, "displayName" : "phospho-p-T210-PLK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 427, "y" : 2177 }, "minX" : 177, "maxX" : 1744, "minY" : 1896, "maxY" : 2193, "prop" : { "x" : 376, "y" : 2162, "width" : 103, "height" : 31 }, "textPosition" : { "x" : 388, "y" : 2160 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 479, "y" : 2162 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 479, "y" : 2162 } } }, "connectors" : [ { "edgeId" : 105474, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105434, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 482, "y" : 2162 }, "to" : { "x" : 620, "y" : 2123 } }, { "from" : { "x" : 620, "y" : 2123 }, "to" : { "x" : 772, "y" : 1902 } }, { "from" : { "x" : 772, "y" : 1902 }, "to" : { "x" : 1540, "y" : 1896 } }, { "from" : { "x" : 1540, "y" : 1896 }, "to" : { "x" : 1541, "y" : 2050 } }, { "from" : { "x" : 1541, "y" : 2050 }, "to" : { "x" : 1736, "y" : 2048 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1740, "y" : 2048 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1740, "y" : 2048 } } }, { "edgeId" : 105455, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 420, "y" : 2159 }, "to" : { "x" : 397, "y" : 2107 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 414, "y" : 2154 }, "b" : { "x" : 420, "y" : 2159 }, "c" : { "x" : 421, "y" : 2151 }, "type" : "ARROW", "centre" : { "x" : 421, "y" : 2151 } } }, { "edgeId" : 105466, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 373, "y" : 2177 }, "to" : { "x" : 183, "y" : 2180 } }, { "from" : { "x" : 183, "y" : 2180 }, "to" : { "x" : 182, "y" : 2167 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 181, "y" : 2163 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 181, "y" : 2163 } } } ] }, { "id" : 105438, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1806, "y" : 2024 }, "minX" : 1750, "maxX" : 1825, "minY" : 2011, "maxY" : 2037, "prop" : { "x" : 1788, "y" : 2012, "width" : 36, "height" : 25 }, "textPosition" : { "x" : 1789, "y" : 2014 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1819, "y" : 2017 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1819, "y" : 2017 } } }, "connectors" : [ { "edgeId" : 105434, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1785, "y" : 2023 }, "to" : { "x" : 1750, "y" : 2021 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1778, "y" : 2027 }, "b" : { "x" : 1785, "y" : 2023 }, "c" : { "x" : 1778, "y" : 2019 }, "type" : "ARROW", "centre" : { "x" : 1778, "y" : 2019 } } } ] }, { "id" : 105441, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1709, "y" : 1097 }, "minX" : 1691, "maxX" : 1729, "minY" : 1083, "maxY" : 1156, "prop" : { "x" : 1691, "y" : 1084, "width" : 37, "height" : 26 }, "textPosition" : { "x" : 1694, "y" : 1086 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1723, "y" : 1089 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1723, "y" : 1089 } } }, "connectors" : [ { "edgeId" : 105440, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1709, "y" : 1113 }, "to" : { "x" : 1709, "y" : 1156 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105443, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1782, "y" : 1103 }, "minX" : 1761, "maxX" : 1805, "minY" : 1088, "maxY" : 1154, "prop" : { "x" : 1761, "y" : 1089, "width" : 43, "height" : 28 }, "textPosition" : { "x" : 1766, "y" : 1092 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1799, "y" : 1094 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1799, "y" : 1094 } } }, "connectors" : [ { "edgeId" : 105440, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1779, "y" : 1120 }, "to" : { "x" : 1774, "y" : 1154 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1782, "y" : 1127 }, "b" : { "x" : 1779, "y" : 1120 }, "c" : { "x" : 1774, "y" : 1126 }, "type" : "ARROW", "centre" : { "x" : 1774, "y" : 1126 } } } ] }, { "id" : 105442, "reactomeId" : 10838112, "displayName" : "PKMYT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1654, "y" : 1132 }, "minX" : 1621, "maxX" : 1709, "minY" : 1115, "maxY" : 1156, "prop" : { "x" : 1621, "y" : 1121, "width" : 66, "height" : 22 }, "textPosition" : { "x" : 1626, "y" : 1121 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1687, "y" : 1121 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1687, "y" : 1121 } } }, "connectors" : [ { "edgeId" : 105440, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1679, "y" : 1146 }, "to" : { "x" : 1709, "y" : 1156 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105444, "reactomeId" : 10838115, "displayName" : "phospho-p-PKMYT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1872, "y" : 1149 }, "minX" : 1774, "maxX" : 1926, "minY" : 1129, "maxY" : 1163, "prop" : { "x" : 1824, "y" : 1135, "width" : 96, "height" : 28 }, "textPosition" : { "x" : 1832, "y" : 1132 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1920, "y" : 1135 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1920, "y" : 1135 } } }, "connectors" : [ { "edgeId" : 105440, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1821, "y" : 1151 }, "to" : { "x" : 1774, "y" : 1154 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1814, "y" : 1155 }, "b" : { "x" : 1821, "y" : 1151 }, "c" : { "x" : 1814, "y" : 1147 }, "type" : "ARROW", "centre" : { "x" : 1814, "y" : 1147 } } } ] }, { "id" : 105447, "reactomeId" : 10841296, "displayName" : "CCNA:p-T160-CDK2:E2F1/E2F3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 645, "y" : 651 }, "minX" : 585, "maxX" : 770, "minY" : 625, "maxY" : 671, "prop" : { "x" : 585, "y" : 631, "width" : 120, "height" : 40 }, "textPosition" : { "x" : 590, "y" : 636 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 705, "y" : 631 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 705, "y" : 631 } } }, "connectors" : [ { "edgeId" : 105445, "type" : "INPUT", "segments" : [ { "from" : { "x" : 708, "y" : 662 }, "to" : { "x" : 732, "y" : 668 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105445, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 708, "y" : 640 }, "to" : { "x" : 765, "y" : 629 } }, { "from" : { "x" : 765, "y" : 629 }, "to" : { "x" : 766, "y" : 654 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 766, "y" : 658 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 766, "y" : 658 } } }, { "edgeId" : 105452, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105446, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 648, "y" : 704 }, "minX" : 627, "maxX" : 732, "minY" : 668, "maxY" : 716, "prop" : { "x" : 627, "y" : 693, "width" : 43, "height" : 23 }, "textPosition" : { "x" : 633, "y" : 694 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 665, "y" : 698 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 665, "y" : 698 } } }, "connectors" : [ { "edgeId" : 105445, "type" : "INPUT", "segments" : [ { "from" : { "x" : 673, "y" : 694 }, "to" : { "x" : 732, "y" : 668 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105449, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 844, "y" : 701 }, "minX" : 800, "maxX" : 868, "minY" : 668, "maxY" : 712, "prop" : { "x" : 822, "y" : 690, "width" : 45, "height" : 22 }, "textPosition" : { "x" : 828, "y" : 690 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 862, "y" : 695 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 862, "y" : 695 } } }, "connectors" : [ { "edgeId" : 105445, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 829, "y" : 687 }, "to" : { "x" : 800, "y" : 668 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 821, "y" : 687 }, "b" : { "x" : 829, "y" : 687 }, "c" : { "x" : 825, "y" : 680 }, "type" : "ARROW", "centre" : { "x" : 825, "y" : 680 } } } ] }, { "id" : 105448, "reactomeId" : 10841324, "displayName" : "CCNA:p-T160-CDK2:p-E2F1/p-E2F3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 859, "y" : 636 }, "minX" : 789, "maxX" : 935, "minY" : 612, "maxY" : 668, "prop" : { "x" : 789, "y" : 618, "width" : 140, "height" : 37 }, "textPosition" : { "x" : 789, "y" : 620 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 929, "y" : 618 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 929, "y" : 618 } } }, "connectors" : [ { "edgeId" : 105445, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 824, "y" : 658 }, "to" : { "x" : 800, "y" : 668 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 819, "y" : 664 }, "b" : { "x" : 824, "y" : 658 }, "c" : { "x" : 816, "y" : 657 }, "type" : "ARROW", "centre" : { "x" : 816, "y" : 657 } } } ] }, { "id" : 105451, "reactomeId" : 10839791, "displayName" : "Homologues of p-S198-CDC25C", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1766, "y" : 1811 }, "minX" : 1707, "maxX" : 1825, "minY" : 1797, "maxY" : 1825, "prop" : { "x" : 1707, "y" : 1797, "width" : 118, "height" : 28 }, "textPosition" : { "x" : 1707, "y" : 1794 }, "connectors" : [ { "edgeId" : 105450, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105453, "reactomeId" : 10841294, "displayName" : "E2F1/E2F3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 442, "y" : 607 }, "minX" : 404, "maxX" : 504, "minY" : 594, "maxY" : 654, "prop" : { "x" : 404, "y" : 594, "width" : 77, "height" : 27 }, "textPosition" : { "x" : 405, "y" : 597 }, "connectors" : [ { "edgeId" : 105452, "type" : "INPUT", "segments" : [ { "from" : { "x" : 459, "y" : 627 }, "to" : { "x" : 504, "y" : 654 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105454, "reactomeId" : 10829812, "displayName" : "CCNA:p-T160-CDK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 453, "y" : 708 }, "minX" : 385, "maxX" : 528, "minY" : 654, "maxY" : 720, "prop" : { "x" : 385, "y" : 697, "width" : 137, "height" : 23 }, "textPosition" : { "x" : 391, "y" : 699 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 522, "y" : 697 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 522, "y" : 697 } } }, "connectors" : [ { "edgeId" : 105452, "type" : "INPUT", "segments" : [ { "from" : { "x" : 463, "y" : 694 }, "to" : { "x" : 504, "y" : 654 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105457, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 532, "y" : 2088 }, "minX" : 456, "maxX" : 553, "minY" : 2077, "maxY" : 2102, "prop" : { "x" : 512, "y" : 2078, "width" : 40, "height" : 20 }, "textPosition" : { "x" : 516, "y" : 2078 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 547, "y" : 2083 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 547, "y" : 2083 } } }, "connectors" : [ { "edgeId" : 105455, "type" : "INPUT", "segments" : [ { "from" : { "x" : 509, "y" : 2091 }, "to" : { "x" : 456, "y" : 2102 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105456, "reactomeId" : 10872501, "displayName" : "p-7S,2T-BORA:p-T210-PLK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 560, "y" : 1987 }, "minX" : 423, "maxX" : 618, "minY" : 1965, "maxY" : 2102, "prop" : { "x" : 509, "y" : 1971, "width" : 103, "height" : 33 }, "textPosition" : { "x" : 512, "y" : 1969 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 612, "y" : 1971 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 612, "y" : 1971 } } }, "connectors" : [ { "edgeId" : 105455, "type" : "INPUT", "segments" : [ { "from" : { "x" : 545, "y" : 2007 }, "to" : { "x" : 456, "y" : 2102 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105455, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 533, "y" : 2007 }, "to" : { "x" : 429, "y" : 2069 } }, { "from" : { "x" : 429, "y" : 2069 }, "to" : { "x" : 427, "y" : 2088 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 427, "y" : 2092 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 427, "y" : 2092 } } } ] }, { "id" : 105459, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 392, "y" : 2047 }, "minX" : 372, "maxX" : 413, "minY" : 2035, "maxY" : 2107, "prop" : { "x" : 372, "y" : 2036, "width" : 40, "height" : 23 }, "textPosition" : { "x" : 375, "y" : 2037 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 407, "y" : 2041 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 407, "y" : 2041 } } }, "connectors" : [ { "edgeId" : 105455, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 392, "y" : 2062 }, "to" : { "x" : 397, "y" : 2107 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 397, "y" : 2068 }, "b" : { "x" : 392, "y" : 2062 }, "c" : { "x" : 389, "y" : 2069 }, "type" : "ARROW", "centre" : { "x" : 389, "y" : 2069 } } } ] }, { "id" : 105458, "reactomeId" : 10872505, "displayName" : "phospho-bora", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 285, "y" : 2065 }, "minX" : 233, "maxX" : 397, "minY" : 2004, "maxY" : 2107, "prop" : { "x" : 233, "y" : 2042, "width" : 105, "height" : 47 }, "textPosition" : { "x" : 237, "y" : 2055 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 338, "y" : 2042 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 338, "y" : 2042 } } }, "connectors" : [ { "edgeId" : 105455, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 341, "y" : 2084 }, "to" : { "x" : 397, "y" : 2107 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 349, "y" : 2083 }, "b" : { "x" : 341, "y" : 2084 }, "c" : { "x" : 346, "y" : 2090 }, "type" : "ARROW", "centre" : { "x" : 346, "y" : 2090 } } }, { "edgeId" : 105460, "type" : "INPUT", "segments" : [ { "from" : { "x" : 320, "y" : 2039 }, "to" : { "x" : 378, "y" : 2004 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105461, "reactomeId" : 10860661, "displayName" : "CUL1:FBXW11:SKP1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 231, "y" : 1979 }, "minX" : 179, "maxX" : 378, "minY" : 1927, "maxY" : 2004, "prop" : { "x" : 179, "y" : 1954, "width" : 105, "height" : 50 }, "textPosition" : { "x" : 183, "y" : 1961 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 284, "y" : 1954 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 284, "y" : 1954 } } }, "connectors" : [ { "edgeId" : 105460, "type" : "INPUT", "segments" : [ { "from" : { "x" : 290, "y" : 1987 }, "to" : { "x" : 378, "y" : 2004 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105463, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 257, "y" : 1948 }, "to" : { "x" : 287, "y" : 1927 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 260, "y" : 1941 }, "b" : { "x" : 257, "y" : 1948 }, "c" : { "x" : 265, "y" : 1947 }, "type" : "ARROW", "centre" : { "x" : 265, "y" : 1947 } } } ] }, { "id" : 105462, "reactomeId" : 10872510, "displayName" : "p-8S,3T-BORA:SCF-beta-TrCp1/2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 504, "y" : 1927 }, "minX" : 321, "maxX" : 581, "minY" : 1898, "maxY" : 1951, "prop" : { "x" : 433, "y" : 1904, "width" : 142, "height" : 47 }, "textPosition" : { "x" : 442, "y" : 1916 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 575, "y" : 1904 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 575, "y" : 1904 } } }, "connectors" : [ { "edgeId" : 105460, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105463, "type" : "INPUT", "segments" : [ { "from" : { "x" : 430, "y" : 1927 }, "to" : { "x" : 363, "y" : 1927 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105463, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 430, "y" : 1915 }, "to" : { "x" : 324, "y" : 1898 } }, { "from" : { "x" : 324, "y" : 1898 }, "to" : { "x" : 324, "y" : 1911 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 325, "y" : 1915 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 325, "y" : 1915 } } } ] }, { "id" : 105465, "reactomeId" : 10872512, "displayName" : "Ub-p-8S,3T-BORA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 220, "y" : 1905 }, "minX" : 176, "maxX" : 287, "minY" : 1881, "maxY" : 1927, "prop" : { "x" : 176, "y" : 1887, "width" : 88, "height" : 36 }, "textPosition" : { "x" : 180, "y" : 1888 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 264, "y" : 1887 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 264, "y" : 1887 } } }, "connectors" : [ { "edgeId" : 105463, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 267, "y" : 1919 }, "to" : { "x" : 287, "y" : 1927 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 275, "y" : 1918 }, "b" : { "x" : 267, "y" : 1919 }, "c" : { "x" : 272, "y" : 1925 }, "type" : "ARROW", "centre" : { "x" : 272, "y" : 1925 } } } ] }, { "id" : 105464, "reactomeId" : 10829864, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 395, "y" : 1961 }, "minX" : 363, "maxX" : 408, "minY" : 1927, "maxY" : 1972, "prop" : { "x" : 383, "y" : 1950, "width" : 25, "height" : 22 }, "textPosition" : { "x" : 383, "y" : 1950 }, "connectors" : [ { "edgeId" : 105463, "type" : "INPUT", "segments" : [ { "from" : { "x" : 384, "y" : 1944 }, "to" : { "x" : 363, "y" : 1927 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105467, "reactomeId" : 10871659, "displayName" : "OPTN:RAB8A:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 276, "y" : 2152 }, "minX" : 201, "maxX" : 322, "minY" : 2130, "maxY" : 2168, "prop" : { "x" : 237, "y" : 2136, "width" : 79, "height" : 32 }, "textPosition" : { "x" : 238, "y" : 2133 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 316, "y" : 2136 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 316, "y" : 2136 } } }, "connectors" : [ { "edgeId" : 105466, "type" : "INPUT", "segments" : [ { "from" : { "x" : 234, "y" : 2152 }, "to" : { "x" : 201, "y" : 2152 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105469, "reactomeId" : 10871657, "displayName" : "RAB8A:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 89, "y" : 2153 }, "minX" : 51, "maxX" : 158, "minY" : 2136, "maxY" : 2164, "prop" : { "x" : 51, "y" : 2142, "width" : 76, "height" : 22 }, "textPosition" : { "x" : 51, "y" : 2143 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 127, "y" : 2142 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 127, "y" : 2142 } } }, "connectors" : [ { "edgeId" : 105466, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 130, "y" : 2151 }, "to" : { "x" : 158, "y" : 2151 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 137, "y" : 2147 }, "b" : { "x" : 130, "y" : 2151 }, "c" : { "x" : 137, "y" : 2155 }, "type" : "ARROW", "centre" : { "x" : 137, "y" : 2155 } } } ] }, { "id" : 105468, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 208, "y" : 2111 }, "minX" : 186, "maxX" : 232, "minY" : 2099, "maxY" : 2152, "prop" : { "x" : 186, "y" : 2100, "width" : 45, "height" : 22 }, "textPosition" : { "x" : 193, "y" : 2100 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 226, "y" : 2105 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 226, "y" : 2105 } } }, "connectors" : [ { "edgeId" : 105466, "type" : "INPUT", "segments" : [ { "from" : { "x" : 206, "y" : 2125 }, "to" : { "x" : 201, "y" : 2152 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105471, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 94, "y" : 2109 }, "minX" : 74, "maxX" : 158, "minY" : 2096, "maxY" : 2151, "prop" : { "x" : 74, "y" : 2097, "width" : 41, "height" : 24 }, "textPosition" : { "x" : 78, "y" : 2098 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 110, "y" : 2102 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 110, "y" : 2102 } } }, "connectors" : [ { "edgeId" : 105466, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 112, "y" : 2124 }, "to" : { "x" : 158, "y" : 2151 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 120, "y" : 2124 }, "b" : { "x" : 112, "y" : 2124 }, "c" : { "x" : 116, "y" : 2131 }, "type" : "ARROW", "centre" : { "x" : 116, "y" : 2131 } } } ] }, { "id" : 105470, "reactomeId" : 10871662, "displayName" : "phospho-p-S177-OPTN", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 158, "y" : 1843 }, "minX" : 105, "maxX" : 217, "minY" : 1827, "maxY" : 2151, "prop" : { "x" : 105, "y" : 1833, "width" : 106, "height" : 21 }, "textPosition" : { "x" : 118, "y" : 1826 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 211, "y" : 1833 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 211, "y" : 1833 } } }, "connectors" : [ { "edgeId" : 105472, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 105466, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 158, "y" : 1857 }, "to" : { "x" : 158, "y" : 2151 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 162, "y" : 1864 }, "b" : { "x" : 158, "y" : 1857 }, "c" : { "x" : 154, "y" : 1864 }, "type" : "ARROW", "centre" : { "x" : 154, "y" : 1864 } } } ] } ], "edges" : [ { "id" : 105409, "reactomeId" : 10839837, "displayName" : "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1476, "y" : 2169 }, "minX" : 1470, "maxX" : 1506, "minY" : 2125, "maxY" : 2230, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1473, "y" : 2125 }, "to" : { "x" : 1476, "y" : 2169 } }, { "from" : { "x" : 1476, "y" : 2169 }, "to" : { "x" : 1506, "y" : 2230 } } ], "reactionShape" : { "a" : { "x" : 1470, "y" : 2163 }, "b" : { "x" : 1482, "y" : 2175 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1476, "y" : 2169 } }, "inputs" : [ { "id" : 105410, "points" : [ { "x" : 1505, "y" : 2121 } ], "stoichiometry" : 2 }, { "id" : 105411, "points" : [ { "x" : 1471, "y" : 2053 } ] } ], "outputs" : [ { "id" : 105412, "points" : [ { "x" : 1486, "y" : 2260 } ] }, { "id" : 105413, "points" : [ { "x" : 1542, "y" : 2230 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 105408, "points" : [ { "x" : 1541, "y" : 2166 } ] } ] }, { "id" : 105472, "reactomeId" : 10871668, "displayName" : "Phosphorylated OPTN translocates to the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 438, "y" : 1847 }, "minX" : 214, "maxX" : 829, "minY" : 1841, "maxY" : 1853, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 214, "y" : 1843 }, "to" : { "x" : 438, "y" : 1847 } }, { "from" : { "x" : 438, "y" : 1847 }, "to" : { "x" : 829, "y" : 1849 } } ], "endShape" : { "a" : { "x" : 822, "y" : 1853 }, "b" : { "x" : 829, "y" : 1849 }, "c" : { "x" : 822, "y" : 1845 }, "type" : "ARROW", "centre" : { "x" : 822, "y" : 1845 } }, "reactionShape" : { "a" : { "x" : 432, "y" : 1841 }, "b" : { "x" : 444, "y" : 1853 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 438, "y" : 1847 } }, "inputs" : [ { "id" : 105470 } ], "outputs" : [ { "id" : 105473 } ] }, { "id" : 105474, "reactomeId" : 10872546, "displayName" : "Cytosolic PLK1 translocates to the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 587, "y" : 2105 }, "minX" : 461, "maxX" : 756, "minY" : 1741, "maxY" : 2159, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 461, "y" : 2159 }, "to" : { "x" : 587, "y" : 2105 } }, { "from" : { "x" : 587, "y" : 2105 }, "to" : { "x" : 756, "y" : 1741 } } ], "endShape" : { "a" : { "x" : 757, "y" : 1749 }, "b" : { "x" : 756, "y" : 1741 }, "c" : { "x" : 749, "y" : 1746 }, "type" : "ARROW", "centre" : { "x" : 749, "y" : 1746 } }, "reactionShape" : { "a" : { "x" : 581, "y" : 2099 }, "b" : { "x" : 593, "y" : 2111 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 587, "y" : 2105 } }, "inputs" : [ { "id" : 105439 } ], "outputs" : [ { "id" : 105475 } ] }, { "id" : 105476, "reactomeId" : 10872565, "displayName" : "Myosin phosphatase dephosphorylates PLK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 886, "y" : 1786 }, "minX" : 843, "maxX" : 925, "minY" : 1780, "maxY" : 1792, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 843, "y" : 1787 }, "to" : { "x" : 886, "y" : 1786 } }, { "from" : { "x" : 886, "y" : 1786 }, "to" : { "x" : 925, "y" : 1786 } } ], "reactionShape" : { "a" : { "x" : 880, "y" : 1780 }, "b" : { "x" : 892, "y" : 1792 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 886, "y" : 1786 } }, "inputs" : [ { "id" : 105475, "points" : [ { "x" : 777, "y" : 1741 } ] }, { "id" : 105477, "points" : [ { "x" : 805, "y" : 1804 } ] } ], "outputs" : [ { "id" : 105478, "points" : [ { "x" : 933, "y" : 1778 } ] }, { "id" : 105479, "points" : [ { "x" : 930, "y" : 1805 } ] } ], "catalysts" : [ { "id" : 105480, "points" : [ { "x" : 888, "y" : 1746 } ] } ], "activators" : [ { "id" : 105473, "points" : [ { "x" : 884, "y" : 1836 } ] } ] }, { "id" : 105414, "reactomeId" : 10839783, "displayName" : "Phosphorylation of Cyclin B1 in the CRS domain", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1390, "y" : 2381 }, "minX" : 1362, "maxX" : 1414, "minY" : 2375, "maxY" : 2387, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1414, "y" : 2381 }, "to" : { "x" : 1390, "y" : 2381 } }, { "from" : { "x" : 1390, "y" : 2381 }, "to" : { "x" : 1362, "y" : 2380 } } ], "reactionShape" : { "a" : { "x" : 1384, "y" : 2375 }, "b" : { "x" : 1396, "y" : 2387 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1390, "y" : 2381 } }, "inputs" : [ { "id" : 105415, "points" : [ { "x" : 1450, "y" : 2408 } ], "stoichiometry" : 4 }, { "id" : 105416, "points" : [ { "x" : 1454, "y" : 2365 } ] } ], "outputs" : [ { "id" : 105417, "points" : [ { "x" : 1323, "y" : 2363 } ] }, { "id" : 105418, "points" : [ { "x" : 1324, "y" : 2396 } ], "stoichiometry" : 4 } ], "catalysts" : [ { "id" : 105419, "points" : [ { "x" : 1390, "y" : 2418 } ] } ] }, { "id" : 105481, "reactomeId" : 10874992, "displayName" : "CCNB:CDK1 phosphorylates BORA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 894, "y" : 2103 }, "minX" : 888, "maxX" : 900, "minY" : 2069, "maxY" : 2123, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 894, "y" : 2069 }, "to" : { "x" : 894, "y" : 2103 } }, { "from" : { "x" : 894, "y" : 2103 }, "to" : { "x" : 890, "y" : 2123 } } ], "reactionShape" : { "a" : { "x" : 888, "y" : 2097 }, "b" : { "x" : 900, "y" : 2109 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 894, "y" : 2103 } }, "inputs" : [ { "id" : 105482, "points" : [ { "x" : 883, "y" : 2034 } ] }, { "id" : 105483, "points" : [ { "x" : 852, "y" : 2066 } ], "stoichiometry" : 9 } ], "outputs" : [ { "id" : 105484, "points" : [ { "x" : 855, "y" : 2134 } ], "stoichiometry" : 9 }, { "id" : 105485, "points" : [ { "x" : 899, "y" : 2166 } ] } ], "catalysts" : [ { "id" : 105412, "points" : [ { "x" : 1421, "y" : 2283 }, { "x" : 1044, "y" : 2295 }, { "x" : 987, "y" : 2159 } ] } ] }, { "id" : 105420, "reactomeId" : 10839785, "displayName" : "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1987, "y" : 1851 }, "minX" : 1981, "maxX" : 2012, "minY" : 1711, "maxY" : 1941, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2012, "y" : 1941 }, "to" : { "x" : 1987, "y" : 1851 } }, { "from" : { "x" : 1987, "y" : 1851 }, "to" : { "x" : 1986, "y" : 1711 } } ], "endShape" : { "a" : { "x" : 1990, "y" : 1718 }, "b" : { "x" : 1986, "y" : 1711 }, "c" : { "x" : 1982, "y" : 1718 }, "type" : "ARROW", "centre" : { "x" : 1982, "y" : 1718 } }, "reactionShape" : { "a" : { "x" : 1981, "y" : 1845 }, "b" : { "x" : 1993, "y" : 1857 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1987, "y" : 1851 } }, "inputs" : [ { "id" : 105421 } ], "outputs" : [ { "id" : 105422 } ] }, { "id" : 105423, "reactomeId" : 10839826, "displayName" : "Translocation of Cdc25 to the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1659, "y" : 1787 }, "minX" : 1564, "maxX" : 1665, "minY" : 991, "maxY" : 2092, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1663, "y" : 2092 }, "to" : { "x" : 1659, "y" : 1787 } }, { "from" : { "x" : 1659, "y" : 1787 }, "to" : { "x" : 1564, "y" : 991 } } ], "endShape" : { "a" : { "x" : 1569, "y" : 997 }, "b" : { "x" : 1564, "y" : 991 }, "c" : { "x" : 1561, "y" : 998 }, "type" : "ARROW", "centre" : { "x" : 1561, "y" : 998 } }, "reactionShape" : { "a" : { "x" : 1653, "y" : 1781 }, "b" : { "x" : 1665, "y" : 1793 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1659, "y" : 1787 } }, "inputs" : [ { "id" : 105424 } ], "outputs" : [ { "id" : 105425 } ] }, { "id" : 105359, "reactomeId" : 10839768, "displayName" : "PKMYT1 phosphorylates CCNA:CDK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 182, "y" : 1063 }, "minX" : 176, "maxX" : 188, "minY" : 1031, "maxY" : 1087, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 182, "y" : 1087 }, "to" : { "x" : 182, "y" : 1063 } }, { "from" : { "x" : 182, "y" : 1063 }, "to" : { "x" : 181, "y" : 1031 } } ], "reactionShape" : { "a" : { "x" : 176, "y" : 1057 }, "b" : { "x" : 188, "y" : 1069 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 182, "y" : 1063 } }, "inputs" : [ { "id" : 105360, "points" : [ { "x" : 126, "y" : 1107 } ] }, { "id" : 105361, "points" : [ { "x" : 182, "y" : 1109 } ] } ], "outputs" : [ { "id" : 105362, "points" : [ { "x" : 134, "y" : 1012 } ] }, { "id" : 105363, "points" : [ { "x" : 212, "y" : 1018 } ] } ], "catalysts" : [ { "id" : 105364, "points" : [ { "x" : 107, "y" : 1063 } ] } ] }, { "id" : 105486, "reactomeId" : 10894337, "displayName" : "SCF:FBXL7 binds AURKA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 145, "y" : 2394 }, "minX" : 139, "maxX" : 188, "minY" : 2378, "maxY" : 2429, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 188, "y" : 2378 }, "to" : { "x" : 145, "y" : 2394 } }, { "from" : { "x" : 145, "y" : 2394 }, "to" : { "x" : 146, "y" : 2429 } } ], "endShape" : { "a" : { "x" : 142, "y" : 2422 }, "b" : { "x" : 146, "y" : 2429 }, "c" : { "x" : 150, "y" : 2422 }, "type" : "ARROW", "centre" : { "x" : 150, "y" : 2422 } }, "reactionShape" : { "c" : { "x" : 145, "y" : 2394 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 145, "y" : 2394 } }, "inputs" : [ { "id" : 105487, "points" : [ { "x" : 287, "y" : 2420 } ] }, { "id" : 105488, "points" : [ { "x" : 138, "y" : 2302 } ] } ], "outputs" : [ { "id" : 105489 } ] }, { "id" : 105426, "reactomeId" : 10839800, "displayName" : "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1646, "y" : 984 }, "minX" : 1640, "maxX" : 1653, "minY" : 947, "maxY" : 1054, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1642, "y" : 1054 }, "to" : { "x" : 1646, "y" : 984 } }, { "from" : { "x" : 1646, "y" : 984 }, "to" : { "x" : 1653, "y" : 947 } } ], "reactionShape" : { "a" : { "x" : 1640, "y" : 978 }, "b" : { "x" : 1652, "y" : 990 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1646, "y" : 984 } }, "inputs" : [ { "id" : 105400, "points" : [ { "x" : 1426, "y" : 1287 } ] }, { "id" : 105427, "points" : [ { "x" : 1688, "y" : 1054 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 105428, "points" : [ { "x" : 1688, "y" : 881 } ] }, { "id" : 105379, "points" : [ { "x" : 1524, "y" : 915 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 105425, "points" : [ { "x" : 1601, "y" : 977 } ] } ] }, { "id" : 105490, "reactomeId" : 10894424, "displayName" : "SCF-FBXL7 ubiquitinates AURKA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 158, "y" : 2534 }, "minX" : 152, "maxX" : 164, "minY" : 2504, "maxY" : 2601, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 155, "y" : 2504 }, "to" : { "x" : 158, "y" : 2534 } }, { "from" : { "x" : 158, "y" : 2534 }, "to" : { "x" : 154, "y" : 2601 } } ], "endShape" : { "a" : { "x" : 150, "y" : 2594 }, "b" : { "x" : 154, "y" : 2601 }, "c" : { "x" : 158, "y" : 2594 }, "type" : "ARROW", "centre" : { "x" : 158, "y" : 2594 } }, "reactionShape" : { "a" : { "x" : 152, "y" : 2528 }, "b" : { "x" : 164, "y" : 2540 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 158, "y" : 2534 } }, "inputs" : [ { "id" : 105489, "points" : [ { "x" : 150, "y" : 2474 } ] }, { "id" : 105491, "points" : [ { "x" : 128, "y" : 2523 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 105492 } ], "catalysts" : [ { "id" : 105489, "points" : [ { "x" : 163, "y" : 2474 }, { "x" : 185, "y" : 2498 } ] } ] }, { "id" : 105429, "reactomeId" : 10837577, "displayName" : "Inactivation of Wee1 kinase", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1722, "y" : 1260 }, "minX" : 1548, "maxX" : 1747, "minY" : 1180, "maxY" : 1266, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1548, "y" : 1180 }, "to" : { "x" : 1722, "y" : 1260 } }, { "from" : { "x" : 1722, "y" : 1260 }, "to" : { "x" : 1747, "y" : 1260 } } ], "reactionShape" : { "a" : { "x" : 1716, "y" : 1254 }, "b" : { "x" : 1728, "y" : 1266 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1722, "y" : 1260 } }, "inputs" : [ { "id" : 105376, "points" : [ { "x" : 1374, "y" : 1099 } ] }, { "id" : 105430, "points" : [ { "x" : 1545, "y" : 1232 } ] } ], "outputs" : [ { "id" : 105431, "points" : [ { "x" : 1757, "y" : 1299 } ] }, { "id" : 105432, "points" : [ { "x" : 1773, "y" : 1260 } ] } ], "catalysts" : [ { "id" : 105433, "points" : [ { "x" : 1721, "y" : 1223 } ] } ] }, { "id" : 105365, "reactomeId" : 10839760, "displayName" : "Translocation of CCNA:p-T14-CDK1 to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 355, "y" : 999 }, "minX" : 301, "maxX" : 983, "minY" : 993, "maxY" : 1005, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 301, "y" : 999 }, "to" : { "x" : 355, "y" : 999 } }, { "from" : { "x" : 355, "y" : 999 }, "to" : { "x" : 983, "y" : 995 } } ], "endShape" : { "a" : { "x" : 976, "y" : 999 }, "b" : { "x" : 983, "y" : 995 }, "c" : { "x" : 976, "y" : 991 }, "type" : "ARROW", "centre" : { "x" : 976, "y" : 991 } }, "reactionShape" : { "a" : { "x" : 349, "y" : 993 }, "b" : { "x" : 361, "y" : 1005 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 355, "y" : 999 } }, "inputs" : [ { "id" : 105363 } ], "outputs" : [ { "id" : 105366 } ] }, { "id" : 105493, "reactomeId" : 10894426, "displayName" : "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 135, "y" : 2744 }, "minX" : 53, "maxX" : 150, "minY" : 2562, "maxY" : 2750, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 150, "y" : 2647 }, "to" : { "x" : 135, "y" : 2744 } }, { "from" : { "x" : 135, "y" : 2744 }, "to" : { "x" : 63, "y" : 2688 } }, { "from" : { "x" : 63, "y" : 2688 }, "to" : { "x" : 53, "y" : 2562 } } ], "reactionShape" : { "a" : { "x" : 129, "y" : 2738 }, "b" : { "x" : 141, "y" : 2750 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 135, "y" : 2744 } }, "inputs" : [ { "id" : 105492 } ], "outputs" : [ { "id" : 105488, "points" : [ { "x" : 113, "y" : 2302 }, { "x" : 66, "y" : 2363 } ] }, { "id" : 105491, "points" : [ { "x" : 87, "y" : 2549 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 105494, "points" : [ { "x" : 351, "y" : 2740 } ] } ] }, { "id" : 105495, "reactomeId" : 10894438, "displayName" : "Formation of the SCF-FBXL7 complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 39, "y" : 2283 }, "minX" : 33, "maxX" : 77, "minY" : 2277, "maxY" : 2873, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 47, "y" : 2873 }, "to" : { "x" : 39, "y" : 2283 } }, { "from" : { "x" : 39, "y" : 2283 }, "to" : { "x" : 77, "y" : 2282 } } ], "endShape" : { "a" : { "x" : 70, "y" : 2286 }, "b" : { "x" : 77, "y" : 2282 }, "c" : { "x" : 70, "y" : 2278 }, "type" : "ARROW", "centre" : { "x" : 70, "y" : 2278 } }, "reactionShape" : { "c" : { "x" : 39, "y" : 2283 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 39, "y" : 2283 } }, "inputs" : [ { "id" : 105496, "points" : [ { "x" : 186, "y" : 2934 } ] }, { "id" : 105497, "points" : [ { "x" : 118, "y" : 2932 } ] }, { "id" : 105498, "points" : [ { "x" : 158, "y" : 2872 } ] }, { "id" : 105499, "points" : [ { "x" : 52, "y" : 2908 } ] } ], "outputs" : [ { "id" : 105488 } ] }, { "id" : 105367, "reactomeId" : 10839748, "displayName" : "CAK phosphorylates CDK1 bound to CCNA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1109, "y" : 1089 }, "minX" : 1103, "maxX" : 1115, "minY" : 1059, "maxY" : 1128, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1109, "y" : 1059 }, "to" : { "x" : 1109, "y" : 1089 } }, { "from" : { "x" : 1109, "y" : 1089 }, "to" : { "x" : 1109, "y" : 1128 } } ], "reactionShape" : { "a" : { "x" : 1103, "y" : 1083 }, "b" : { "x" : 1115, "y" : 1095 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1109, "y" : 1089 } }, "inputs" : [ { "id" : 105368, "points" : [ { "x" : 1126, "y" : 1045 } ] }, { "id" : 105366, "points" : [ { "x" : 1064, "y" : 1015 } ] } ], "outputs" : [ { "id" : 105369, "points" : [ { "x" : 1099, "y" : 1151 } ] }, { "id" : 105370, "points" : [ { "x" : 1132, "y" : 1136 } ] } ], "catalysts" : [ { "id" : 105371, "points" : [ { "x" : 1068, "y" : 1089 } ] } ] }, { "id" : 105434, "reactomeId" : 10837561, "displayName" : "Activation of Cdc25C", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1752, "y" : 2048 }, "minX" : 1746, "maxX" : 1758, "minY" : 2021, "maxY" : 2102, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1758, "y" : 2102 }, "to" : { "x" : 1752, "y" : 2048 } }, { "from" : { "x" : 1752, "y" : 2048 }, "to" : { "x" : 1750, "y" : 2021 } } ], "reactionShape" : { "a" : { "x" : 1746, "y" : 2042 }, "b" : { "x" : 1758, "y" : 2054 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1752, "y" : 2048 } }, "inputs" : [ { "id" : 105435, "points" : [ { "x" : 1761, "y" : 2133 } ] }, { "id" : 105436, "points" : [ { "x" : 1816, "y" : 2131 } ] } ], "outputs" : [ { "id" : 105437, "points" : [ { "x" : 1750, "y" : 1931 } ] }, { "id" : 105438, "points" : [ { "x" : 1785, "y" : 2023 } ] } ], "catalysts" : [ { "id" : 105439, "points" : [ { "x" : 482, "y" : 2162 }, { "x" : 620, "y" : 2123 }, { "x" : 772, "y" : 1902 }, { "x" : 1540, "y" : 1896 }, { "x" : 1541, "y" : 2050 } ] } ] }, { "id" : 105500, "reactomeId" : 10894436, "displayName" : "SCF-FBXL18 ubiquitinates FBXL7", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 295, "y" : 2872 }, "minX" : 256, "maxX" : 343, "minY" : 2866, "maxY" : 2878, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 256, "y" : 2872 }, "to" : { "x" : 295, "y" : 2872 } }, { "from" : { "x" : 295, "y" : 2872 }, "to" : { "x" : 343, "y" : 2872 } } ], "endShape" : { "a" : { "x" : 336, "y" : 2876 }, "b" : { "x" : 343, "y" : 2872 }, "c" : { "x" : 336, "y" : 2868 }, "type" : "ARROW", "centre" : { "x" : 336, "y" : 2868 } }, "reactionShape" : { "a" : { "x" : 289, "y" : 2866 }, "b" : { "x" : 301, "y" : 2878 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 295, "y" : 2872 } }, "inputs" : [ { "id" : 105498, "points" : [ { "x" : 217, "y" : 2872 } ] }, { "id" : 105501, "points" : [ { "x" : 358, "y" : 2923 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 105502 } ], "catalysts" : [ { "id" : 105503, "points" : [ { "x" : 293, "y" : 2836 } ] } ] }, { "id" : 105372, "reactomeId" : 10839808, "displayName" : "WEE1 phosphorylates CCNA:CDK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1243, "y" : 1089 }, "minX" : 1237, "maxX" : 1249, "minY" : 1055, "maxY" : 1123, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1243, "y" : 1123 }, "to" : { "x" : 1243, "y" : 1089 } }, { "from" : { "x" : 1243, "y" : 1089 }, "to" : { "x" : 1243, "y" : 1055 } } ], "reactionShape" : { "a" : { "x" : 1237, "y" : 1083 }, "b" : { "x" : 1249, "y" : 1095 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1243, "y" : 1089 } }, "inputs" : [ { "id" : 105373, "points" : [ { "x" : 1265, "y" : 1135 } ] }, { "id" : 105370, "points" : [ { "x" : 1222, "y" : 1126 } ] } ], "outputs" : [ { "id" : 105374, "points" : [ { "x" : 1313, "y" : 1033 } ] }, { "id" : 105375, "points" : [ { "x" : 1284, "y" : 1003 } ] } ], "catalysts" : [ { "id" : 105376, "points" : [ { "x" : 1315, "y" : 1088 } ] } ] }, { "id" : 105377, "reactomeId" : 10839816, "displayName" : "CDC25A dephosphorylates CCNA:CDK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1431, "y" : 978 }, "minX" : 1425, "maxX" : 1437, "minY" : 950, "maxY" : 1011, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1430, "y" : 1011 }, "to" : { "x" : 1431, "y" : 978 } }, { "from" : { "x" : 1431, "y" : 978 }, "to" : { "x" : 1430, "y" : 950 } } ], "reactionShape" : { "a" : { "x" : 1425, "y" : 972 }, "b" : { "x" : 1437, "y" : 984 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1431, "y" : 978 } }, "inputs" : [ { "id" : 105378, "points" : [ { "x" : 1439, "y" : 1043 } ], "stoichiometry" : 2 }, { "id" : 105375, "points" : [ { "x" : 1361, "y" : 992 } ] } ], "outputs" : [ { "id" : 105379, "points" : [ { "x" : 1491, "y" : 918 } ], "stoichiometry" : 2 }, { "id" : 105380, "points" : [ { "x" : 1377, "y" : 922 } ] } ], "catalysts" : [ { "id" : 105381, "points" : [ { "x" : 1479, "y" : 1540 }, { "x" : 1514, "y" : 1541 }, { "x" : 1502, "y" : 983 } ] } ] }, { "id" : 105505, "reactomeId" : 10894812, "displayName" : "PP2A methylation by LCMT1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 527, "y" : 1629 }, "minX" : 521, "maxX" : 533, "minY" : 1600, "maxY" : 1655, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 527, "y" : 1600 }, "to" : { "x" : 527, "y" : 1629 } }, { "from" : { "x" : 527, "y" : 1629 }, "to" : { "x" : 527, "y" : 1655 } } ], "reactionShape" : { "a" : { "x" : 521, "y" : 1623 }, "b" : { "x" : 533, "y" : 1635 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 527, "y" : 1629 } }, "inputs" : [ { "id" : 105506, "points" : [ { "x" : 540, "y" : 1523 } ] }, { "id" : 105507, "points" : [ { "x" : 554, "y" : 1590 } ] } ], "outputs" : [ { "id" : 105508, "points" : [ { "x" : 528, "y" : 1725 } ] }, { "id" : 105509, "points" : [ { "x" : 560, "y" : 1674 } ] } ], "catalysts" : [ { "id" : 105510, "points" : [ { "x" : 562, "y" : 1629 } ] } ] }, { "id" : 105440, "reactomeId" : 10838117, "displayName" : "Inactivation of Myt1 kinase", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1745, "y" : 1155 }, "minX" : 1709, "maxX" : 1774, "minY" : 1149, "maxY" : 1161, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1709, "y" : 1156 }, "to" : { "x" : 1745, "y" : 1155 } }, { "from" : { "x" : 1745, "y" : 1155 }, "to" : { "x" : 1774, "y" : 1154 } } ], "reactionShape" : { "a" : { "x" : 1739, "y" : 1149 }, "b" : { "x" : 1751, "y" : 1161 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1745, "y" : 1155 } }, "inputs" : [ { "id" : 105441, "points" : [ { "x" : 1709, "y" : 1113 } ] }, { "id" : 105442, "points" : [ { "x" : 1679, "y" : 1146 } ] } ], "outputs" : [ { "id" : 105443, "points" : [ { "x" : 1779, "y" : 1120 } ] }, { "id" : 105444, "points" : [ { "x" : 1821, "y" : 1151 } ] } ], "catalysts" : [ { "id" : 105433, "points" : [ { "x" : 1726, "y" : 1193 } ] } ] }, { "id" : 105504, "reactomeId" : 10894440, "displayName" : "Proteasome-mediated degradation of PolyUb-FBXL7", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 525, "y" : 2910 }, "minX" : 420, "maxX" : 531, "minY" : 2894, "maxY" : 2936, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 470, "y" : 2894 }, "to" : { "x" : 525, "y" : 2910 } }, { "from" : { "x" : 525, "y" : 2910 }, "to" : { "x" : 420, "y" : 2936 } } ], "endShape" : { "a" : { "x" : 426, "y" : 2930 }, "b" : { "x" : 420, "y" : 2936 }, "c" : { "x" : 428, "y" : 2938 }, "type" : "ARROW", "centre" : { "x" : 428, "y" : 2938 } }, "reactionShape" : { "a" : { "x" : 519, "y" : 2904 }, "b" : { "x" : 531, "y" : 2916 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 525, "y" : 2910 } }, "inputs" : [ { "id" : 105502 } ], "outputs" : [ { "id" : 105501, "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 105494, "points" : [ { "x" : 470, "y" : 2740 }, { "x" : 528, "y" : 2740 } ] } ] }, { "id" : 105445, "reactomeId" : 10841327, "displayName" : "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 767, "y" : 670 }, "minX" : 732, "maxX" : 800, "minY" : 664, "maxY" : 676, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 732, "y" : 668 }, "to" : { "x" : 767, "y" : 670 } }, { "from" : { "x" : 767, "y" : 670 }, "to" : { "x" : 800, "y" : 668 } } ], "reactionShape" : { "a" : { "x" : 761, "y" : 664 }, "b" : { "x" : 773, "y" : 676 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 767, "y" : 670 } }, "inputs" : [ { "id" : 105446, "points" : [ { "x" : 673, "y" : 694 } ] }, { "id" : 105447, "points" : [ { "x" : 708, "y" : 662 } ] } ], "outputs" : [ { "id" : 105448, "points" : [ { "x" : 824, "y" : 658 } ] }, { "id" : 105449, "points" : [ { "x" : 829, "y" : 687 } ] } ], "catalysts" : [ { "id" : 105447, "points" : [ { "x" : 708, "y" : 640 }, { "x" : 765, "y" : 629 } ] } ] }, { "id" : 105511, "reactomeId" : 10894820, "displayName" : "PP2A demethylation by PPME1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 486, "y" : 1628 }, "minX" : 480, "maxX" : 492, "minY" : 1583, "maxY" : 1687, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 488, "y" : 1687 }, "to" : { "x" : 486, "y" : 1628 } }, { "from" : { "x" : 486, "y" : 1628 }, "to" : { "x" : 487, "y" : 1583 } } ], "reactionShape" : { "a" : { "x" : 480, "y" : 1622 }, "b" : { "x" : 492, "y" : 1634 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 486, "y" : 1628 } }, "inputs" : [ { "id" : 105512, "points" : [ { "x" : 458, "y" : 1717 } ] }, { "id" : 105508, "points" : [ { "x" : 520, "y" : 1725 } ] } ], "outputs" : [ { "id" : 105513, "points" : [ { "x" : 460, "y" : 1530 } ] }, { "id" : 105506, "points" : [ { "x" : 533, "y" : 1523 } ] } ], "catalysts" : [ { "id" : 105514, "points" : [ { "x" : 458, "y" : 1628 } ] } ] }, { "id" : 105382, "reactomeId" : 10839704, "displayName" : "Formation of Cyclin B:Cdc2 complexes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 218, "y" : 1286 }, "minX" : 204, "maxX" : 227, "minY" : 1254, "maxY" : 1325, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 227, "y" : 1254 }, "to" : { "x" : 218, "y" : 1286 } }, { "from" : { "x" : 218, "y" : 1286 }, "to" : { "x" : 210, "y" : 1319 } } ], "endShape" : { "a" : { "x" : 208, "y" : 1311 }, "b" : { "x" : 210, "y" : 1319 }, "c" : { "x" : 216, "y" : 1313 }, "type" : "ARROW", "centre" : { "x" : 216, "y" : 1313 } }, "reactionShape" : { "c" : { "x" : 218, "y" : 1286 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 218, "y" : 1286 } }, "inputs" : [ { "id" : 105383, "points" : [ { "x" : 246, "y" : 1244 } ] }, { "id" : 105384, "points" : [ { "x" : 206, "y" : 1242 } ] } ], "outputs" : [ { "id" : 105385 } ] }, { "id" : 105515, "reactomeId" : 10909273, "displayName" : "Formation of CCNA2:CDK1 complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 209, "y" : 1169 }, "minX" : 203, "maxX" : 251, "minY" : 1143, "maxY" : 1189, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 209, "y" : 1189 }, "to" : { "x" : 209, "y" : 1169 } }, { "from" : { "x" : 209, "y" : 1169 }, "to" : { "x" : 251, "y" : 1143 } } ], "endShape" : { "a" : { "x" : 247, "y" : 1150 }, "b" : { "x" : 251, "y" : 1143 }, "c" : { "x" : 243, "y" : 1143 }, "type" : "ARROW", "centre" : { "x" : 243, "y" : 1143 } }, "reactionShape" : { "c" : { "x" : 209, "y" : 1169 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 209, "y" : 1169 } }, "inputs" : [ { "id" : 105384, "points" : [ { "x" : 197, "y" : 1215 } ] }, { "id" : 105516, "points" : [ { "x" : 246, "y" : 1187 } ] } ], "outputs" : [ { "id" : 105517 } ] }, { "id" : 105450, "reactomeId" : 10839793, "displayName" : "Translocation of active Cdc25C to the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1765, "y" : 1871 }, "minX" : 1754, "maxX" : 1771, "minY" : 1828, "maxY" : 1903, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1754, "y" : 1903 }, "to" : { "x" : 1765, "y" : 1871 } }, { "from" : { "x" : 1765, "y" : 1871 }, "to" : { "x" : 1765, "y" : 1828 } } ], "endShape" : { "a" : { "x" : 1769, "y" : 1835 }, "b" : { "x" : 1765, "y" : 1828 }, "c" : { "x" : 1761, "y" : 1835 }, "type" : "ARROW", "centre" : { "x" : 1761, "y" : 1835 } }, "reactionShape" : { "a" : { "x" : 1759, "y" : 1865 }, "b" : { "x" : 1771, "y" : 1877 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1765, "y" : 1871 } }, "inputs" : [ { "id" : 105437 } ], "outputs" : [ { "id" : 105451 } ] }, { "id" : 105386, "reactomeId" : 10839702, "displayName" : "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 199, "y" : 1436 }, "minX" : 193, "maxX" : 205, "minY" : 1402, "maxY" : 1472, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 199, "y" : 1402 }, "to" : { "x" : 199, "y" : 1436 } }, { "from" : { "x" : 199, "y" : 1436 }, "to" : { "x" : 198, "y" : 1472 } } ], "reactionShape" : { "a" : { "x" : 193, "y" : 1430 }, "b" : { "x" : 205, "y" : 1442 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 199, "y" : 1436 } }, "inputs" : [ { "id" : 105385, "points" : [ { "x" : 206, "y" : 1350 } ] }, { "id" : 105387, "points" : [ { "x" : 170, "y" : 1382 } ] } ], "outputs" : [ { "id" : 105388, "points" : [ { "x" : 159, "y" : 1500 } ] }, { "id" : 105389, "points" : [ { "x" : 202, "y" : 1571 } ] } ], "catalysts" : [ { "id" : 105364, "points" : [ { "x" : 64, "y" : 1077 }, { "x" : 62, "y" : 1434 } ] } ] }, { "id" : 105452, "reactomeId" : 10841298, "displayName" : "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 539, "y" : 653 }, "minX" : 504, "maxX" : 582, "minY" : 647, "maxY" : 659, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 504, "y" : 654 }, "to" : { "x" : 539, "y" : 653 } }, { "from" : { "x" : 539, "y" : 653 }, "to" : { "x" : 582, "y" : 652 } } ], "endShape" : { "a" : { "x" : 575, "y" : 656 }, "b" : { "x" : 582, "y" : 652 }, "c" : { "x" : 575, "y" : 648 }, "type" : "ARROW", "centre" : { "x" : 575, "y" : 648 } }, "reactionShape" : { "c" : { "x" : 539, "y" : 653 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 539, "y" : 653 } }, "inputs" : [ { "id" : 105453, "points" : [ { "x" : 459, "y" : 627 } ] }, { "id" : 105454, "points" : [ { "x" : 463, "y" : 694 } ] } ], "outputs" : [ { "id" : 105447 } ] }, { "id" : 105455, "reactomeId" : 10872508, "displayName" : "PLK1 phosphorylates BORA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 426, "y" : 2104 }, "minX" : 397, "maxX" : 456, "minY" : 2098, "maxY" : 2110, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 456, "y" : 2102 }, "to" : { "x" : 426, "y" : 2104 } }, { "from" : { "x" : 426, "y" : 2104 }, "to" : { "x" : 397, "y" : 2107 } } ], "reactionShape" : { "a" : { "x" : 420, "y" : 2098 }, "b" : { "x" : 432, "y" : 2110 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 426, "y" : 2104 } }, "inputs" : [ { "id" : 105456, "points" : [ { "x" : 545, "y" : 2007 } ] }, { "id" : 105457, "points" : [ { "x" : 509, "y" : 2091 } ] } ], "outputs" : [ { "id" : 105458, "points" : [ { "x" : 341, "y" : 2084 } ] }, { "id" : 105439, "points" : [ { "x" : 420, "y" : 2159 } ] }, { "id" : 105459, "points" : [ { "x" : 392, "y" : 2062 } ] } ], "catalysts" : [ { "id" : 105456, "points" : [ { "x" : 533, "y" : 2007 }, { "x" : 429, "y" : 2069 } ] } ] }, { "id" : 105390, "reactomeId" : 10839691, "displayName" : "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1842, "y" : 1839 }, "minX" : 1836, "maxX" : 1871, "minY" : 1706, "maxY" : 1936, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1871, "y" : 1936 }, "to" : { "x" : 1842, "y" : 1839 } }, { "from" : { "x" : 1842, "y" : 1839 }, "to" : { "x" : 1842, "y" : 1706 } } ], "endShape" : { "a" : { "x" : 1846, "y" : 1713 }, "b" : { "x" : 1842, "y" : 1706 }, "c" : { "x" : 1838, "y" : 1713 }, "type" : "ARROW", "centre" : { "x" : 1838, "y" : 1713 } }, "reactionShape" : { "a" : { "x" : 1836, "y" : 1833 }, "b" : { "x" : 1848, "y" : 1845 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1842, "y" : 1839 } }, "inputs" : [ { "id" : 105391 } ], "outputs" : [ { "id" : 105392 } ] }, { "id" : 105518, "reactomeId" : 10909271, "displayName" : "Formation of CCNA1:CDK1 complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 159, "y" : 1163 }, "minX" : 128, "maxX" : 167, "minY" : 1157, "maxY" : 1185, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 167, "y" : 1185 }, "to" : { "x" : 159, "y" : 1163 } }, { "from" : { "x" : 159, "y" : 1163 }, "to" : { "x" : 128, "y" : 1164 } } ], "endShape" : { "a" : { "x" : 135, "y" : 1160 }, "b" : { "x" : 128, "y" : 1164 }, "c" : { "x" : 135, "y" : 1168 }, "type" : "ARROW", "centre" : { "x" : 135, "y" : 1168 } }, "reactionShape" : { "c" : { "x" : 159, "y" : 1163 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 159, "y" : 1163 } }, "inputs" : [ { "id" : 105384, "points" : [ { "x" : 186, "y" : 1215 } ] }, { "id" : 105519, "points" : [ { "x" : 121, "y" : 1223 } ] } ], "outputs" : [ { "id" : 105520 } ] }, { "id" : 105393, "reactomeId" : 10839734, "displayName" : "CAK phosphorylates CDK1 bound to CCNB1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1066, "y" : 1243 }, "minX" : 1031, "maxX" : 1138, "minY" : 1237, "maxY" : 1249, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1031, "y" : 1246 }, "to" : { "x" : 1066, "y" : 1243 } }, { "from" : { "x" : 1066, "y" : 1243 }, "to" : { "x" : 1138, "y" : 1249 } } ], "reactionShape" : { "a" : { "x" : 1060, "y" : 1237 }, "b" : { "x" : 1072, "y" : 1249 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1066, "y" : 1243 } }, "inputs" : [ { "id" : 105394, "points" : [ { "x" : 1000, "y" : 1216 } ] }, { "id" : 105395, "points" : [ { "x" : 1011, "y" : 1251 } ] } ], "outputs" : [ { "id" : 105396, "points" : [ { "x" : 1200, "y" : 1249 } ] }, { "id" : 105397, "points" : [ { "x" : 1154, "y" : 1227 } ] } ], "catalysts" : [ { "id" : 105371, "points" : [ { "x" : 1049, "y" : 1103 } ] } ] }, { "id" : 105521, "reactomeId" : 10909314, "displayName" : "CDK1 phosphorylates CCNA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1367, "y" : 801 }, "minX" : 1361, "maxX" : 1373, "minY" : 750, "maxY" : 837, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1368, "y" : 837 }, "to" : { "x" : 1367, "y" : 801 } }, { "from" : { "x" : 1367, "y" : 801 }, "to" : { "x" : 1369, "y" : 750 } } ], "reactionShape" : { "a" : { "x" : 1361, "y" : 795 }, "b" : { "x" : 1373, "y" : 807 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1367, "y" : 801 } }, "inputs" : [ { "id" : 105380, "points" : [ { "x" : 1361, "y" : 887 } ] }, { "id" : 105522, "points" : [ { "x" : 1404, "y" : 833 } ] } ], "outputs" : [ { "id" : 105402, "points" : [ { "x" : 1381, "y" : 689 } ] }, { "id" : 105523, "points" : [ { "x" : 1405, "y" : 755 } ] } ], "catalysts" : [ { "id" : 105380, "points" : [ { "x" : 1351, "y" : 887 }, { "x" : 1311, "y" : 835 } ] } ] }, { "id" : 105460, "reactomeId" : 10872517, "displayName" : "Phosphorylated BORA binds SCF-beta-TrCp1/2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 421, "y" : 1979 }, "minX" : 378, "maxX" : 471, "minY" : 1948, "maxY" : 2004, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 378, "y" : 2004 }, "to" : { "x" : 421, "y" : 1979 } }, { "from" : { "x" : 421, "y" : 1979 }, "to" : { "x" : 465, "y" : 1954 } } ], "endShape" : { "a" : { "x" : 461, "y" : 1961 }, "b" : { "x" : 465, "y" : 1954 }, "c" : { "x" : 457, "y" : 1954 }, "type" : "ARROW", "centre" : { "x" : 457, "y" : 1954 } }, "reactionShape" : { "c" : { "x" : 421, "y" : 1979 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 421, "y" : 1979 } }, "inputs" : [ { "id" : 105461, "points" : [ { "x" : 290, "y" : 1987 } ] }, { "id" : 105458, "points" : [ { "x" : 320, "y" : 2039 } ] } ], "outputs" : [ { "id" : 105462 } ] }, { "id" : 105524, "reactomeId" : 10909329, "displayName" : "CCNA:CDK1 complex translocates to the cytosol", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2068, "y" : 744 }, "minX" : 1473, "maxX" : 2294, "minY" : 678, "maxY" : 2486, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1473, "y" : 678 }, "to" : { "x" : 2068, "y" : 744 } }, { "from" : { "x" : 2068, "y" : 744 }, "to" : { "x" : 2294, "y" : 747 } }, { "from" : { "x" : 2294, "y" : 747 }, "to" : { "x" : 2273, "y" : 2484 } }, { "from" : { "x" : 2273, "y" : 2484 }, "to" : { "x" : 2195, "y" : 2486 } } ], "endShape" : { "a" : { "x" : 2202, "y" : 2482 }, "b" : { "x" : 2195, "y" : 2486 }, "c" : { "x" : 2202, "y" : 2490 }, "type" : "ARROW", "centre" : { "x" : 2202, "y" : 2490 } }, "reactionShape" : { "a" : { "x" : 2062, "y" : 738 }, "b" : { "x" : 2074, "y" : 750 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2068, "y" : 744 } }, "inputs" : [ { "id" : 105402 } ], "outputs" : [ { "id" : 105525 } ] }, { "id" : 105463, "reactomeId" : 10872515, "displayName" : "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 325, "y" : 1927 }, "minX" : 287, "maxX" : 363, "minY" : 1921, "maxY" : 1933, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 363, "y" : 1927 }, "to" : { "x" : 325, "y" : 1927 } }, { "from" : { "x" : 325, "y" : 1927 }, "to" : { "x" : 287, "y" : 1927 } } ], "reactionShape" : { "a" : { "x" : 319, "y" : 1921 }, "b" : { "x" : 331, "y" : 1933 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 325, "y" : 1927 } }, "inputs" : [ { "id" : 105462, "points" : [ { "x" : 430, "y" : 1927 } ] }, { "id" : 105464, "points" : [ { "x" : 384, "y" : 1944 } ] } ], "outputs" : [ { "id" : 105465, "points" : [ { "x" : 267, "y" : 1919 } ] }, { "id" : 105461, "points" : [ { "x" : 257, "y" : 1948 } ] } ], "catalysts" : [ { "id" : 105462, "points" : [ { "x" : 430, "y" : 1915 }, { "x" : 324, "y" : 1898 } ] } ] }, { "id" : 105398, "reactomeId" : 10839722, "displayName" : "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1349, "y" : 1231 }, "minX" : 1325, "maxX" : 1383, "minY" : 1225, "maxY" : 1241, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1325, "y" : 1231 }, "to" : { "x" : 1349, "y" : 1231 } }, { "from" : { "x" : 1349, "y" : 1231 }, "to" : { "x" : 1383, "y" : 1241 } } ], "reactionShape" : { "a" : { "x" : 1343, "y" : 1225 }, "b" : { "x" : 1355, "y" : 1237 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1349, "y" : 1231 } }, "inputs" : [ { "id" : 105396, "points" : [ { "x" : 1311, "y" : 1235 } ] }, { "id" : 105399, "points" : [ { "x" : 1309, "y" : 1221 } ] } ], "outputs" : [ { "id" : 105400, "points" : [ { "x" : 1402, "y" : 1287 } ] }, { "id" : 105401, "points" : [ { "x" : 1403, "y" : 1222 } ] } ], "catalysts" : [ { "id" : 105376, "points" : [ { "x" : 1344, "y" : 1105 } ] } ], "inhibitors" : [ { "id" : 105402, "points" : [ { "x" : 1396, "y" : 689 }, { "x" : 1467, "y" : 760 }, { "x" : 1481, "y" : 1130 } ] } ] }, { "id" : 105526, "reactomeId" : 10909336, "displayName" : "CCNA:CDK1 phosphorylates WEE1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1207, "y" : 830 }, "minX" : 1201, "maxX" : 1215, "minY" : 732, "maxY" : 1055, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1215, "y" : 1055 }, "to" : { "x" : 1207, "y" : 830 } }, { "from" : { "x" : 1207, "y" : 830 }, "to" : { "x" : 1209, "y" : 732 } } ], "reactionShape" : { "a" : { "x" : 1201, "y" : 824 }, "b" : { "x" : 1213, "y" : 836 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1207, "y" : 830 } }, "inputs" : [ { "id" : 105376, "points" : [ { "x" : 1315, "y" : 1081 } ] }, { "id" : 105368, "points" : [ { "x" : 1163, "y" : 1034 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 105527, "points" : [ { "x" : 1141, "y" : 707 } ] }, { "id" : 105528, "points" : [ { "x" : 1216, "y" : 667 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 105402, "points" : [ { "x" : 1369, "y" : 689 } ] } ] }, { "id" : 105529, "reactomeId" : 10909327, "displayName" : "CCNA:CDK1 phosphorylates BORA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 917, "y" : 2077 }, "minX" : 902, "maxX" : 923, "minY" : 2050, "maxY" : 2141, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 902, "y" : 2050 }, "to" : { "x" : 917, "y" : 2077 } }, { "from" : { "x" : 917, "y" : 2077 }, "to" : { "x" : 914, "y" : 2141 } } ], "reactionShape" : { "a" : { "x" : 911, "y" : 2071 }, "b" : { "x" : 923, "y" : 2083 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 917, "y" : 2077 } }, "inputs" : [ { "id" : 105482, "points" : [ { "x" : 888, "y" : 2034 } ] }, { "id" : 105483, "points" : [ { "x" : 852, "y" : 2061 } ], "stoichiometry" : 9 } ], "outputs" : [ { "id" : 105485, "points" : [ { "x" : 908, "y" : 2166 } ] }, { "id" : 105484, "points" : [ { "x" : 855, "y" : 2139 } ], "stoichiometry" : 9 } ], "catalysts" : [ { "id" : 105525, "points" : [ { "x" : 2021, "y" : 2493 }, { "x" : 1245, "y" : 2537 }, { "x" : 955, "y" : 2080 } ] } ] }, { "id" : 105403, "reactomeId" : 10839730, "displayName" : "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1493, "y" : 1731 }, "minX" : 1448, "maxX" : 1499, "minY" : 1329, "maxY" : 1912, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1448, "y" : 1329 }, "to" : { "x" : 1483, "y" : 1342 } }, { "from" : { "x" : 1483, "y" : 1342 }, "to" : { "x" : 1496, "y" : 1730 } }, { "from" : { "x" : 1496, "y" : 1730 }, "to" : { "x" : 1493, "y" : 1731 } }, { "from" : { "x" : 1493, "y" : 1731 }, "to" : { "x" : 1470, "y" : 1912 } } ], "endShape" : { "a" : { "x" : 1467, "y" : 1905 }, "b" : { "x" : 1470, "y" : 1912 }, "c" : { "x" : 1475, "y" : 1906 }, "type" : "ARROW", "centre" : { "x" : 1475, "y" : 1906 } }, "reactionShape" : { "a" : { "x" : 1487, "y" : 1725 }, "b" : { "x" : 1499, "y" : 1737 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1493, "y" : 1731 } }, "inputs" : [ { "id" : 105400 } ], "outputs" : [ { "id" : 105404 } ], "activators" : [ { "id" : 105405, "points" : [ { "x" : 1532, "y" : 1720 } ] } ] }, { "id" : 105466, "reactomeId" : 10871664, "displayName" : "PLK1 phosphorylates OPTN", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 180, "y" : 2151 }, "minX" : 158, "maxX" : 201, "minY" : 2145, "maxY" : 2157, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 201, "y" : 2152 }, "to" : { "x" : 180, "y" : 2151 } }, { "from" : { "x" : 180, "y" : 2151 }, "to" : { "x" : 158, "y" : 2151 } } ], "reactionShape" : { "a" : { "x" : 174, "y" : 2145 }, "b" : { "x" : 186, "y" : 2157 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 180, "y" : 2151 } }, "inputs" : [ { "id" : 105467, "points" : [ { "x" : 234, "y" : 2152 } ] }, { "id" : 105468, "points" : [ { "x" : 206, "y" : 2125 } ] } ], "outputs" : [ { "id" : 105469, "points" : [ { "x" : 130, "y" : 2151 } ] }, { "id" : 105470, "points" : [ { "x" : 158, "y" : 1857 } ] }, { "id" : 105471, "points" : [ { "x" : 112, "y" : 2124 } ] } ], "catalysts" : [ { "id" : 105439, "points" : [ { "x" : 373, "y" : 2177 }, { "x" : 183, "y" : 2180 } ] } ] }, { "id" : 105530, "reactomeId" : 10909341, "displayName" : "CCNA:CDK1 phosphorylates FZR1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1830, "y" : 764 }, "minX" : 1780, "maxX" : 1862, "minY" : 758, "maxY" : 770, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1780, "y" : 761 }, "to" : { "x" : 1830, "y" : 764 } }, { "from" : { "x" : 1830, "y" : 764 }, "to" : { "x" : 1862, "y" : 765 } } ], "reactionShape" : { "a" : { "x" : 1824, "y" : 758 }, "b" : { "x" : 1836, "y" : 770 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1830, "y" : 764 } }, "inputs" : [ { "id" : 105531, "points" : [ { "x" : 1746, "y" : 760 } ] }, { "id" : 105532, "points" : [ { "x" : 1764, "y" : 798 } ] } ], "outputs" : [ { "id" : 105533, "points" : [ { "x" : 1935, "y" : 768 } ] }, { "id" : 105534, "points" : [ { "x" : 1901, "y" : 795 } ] } ], "catalysts" : [ { "id" : 105402, "points" : [ { "x" : 1473, "y" : 679 }, { "x" : 1821, "y" : 723 } ] } ] }, { "id" : 105535, "reactomeId" : 10909346, "displayName" : "CCNA:CDK1 phosphorylates CDC25B", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1328, "y" : 384 }, "minX" : 1277, "maxX" : 1365, "minY" : 374, "maxY" : 390, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1277, "y" : 374 }, "to" : { "x" : 1328, "y" : 384 } }, { "from" : { "x" : 1328, "y" : 384 }, "to" : { "x" : 1365, "y" : 389 } } ], "reactionShape" : { "a" : { "x" : 1322, "y" : 378 }, "b" : { "x" : 1334, "y" : 390 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1328, "y" : 384 } }, "inputs" : [ { "id" : 105536, "points" : [ { "x" : 1243, "y" : 338 } ] }, { "id" : 105537, "points" : [ { "x" : 1243, "y" : 384 } ] } ], "outputs" : [ { "id" : 105538, "points" : [ { "x" : 1406, "y" : 391 } ] }, { "id" : 105539, "points" : [ { "x" : 1383, "y" : 344 } ] } ], "catalysts" : [ { "id" : 105402, "points" : [ { "x" : 1381, "y" : 650 } ] } ] }, { "id" : 105406, "reactomeId" : 10839774, "displayName" : "Translocation of Cdc25B to the cytoplasm", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1604, "y" : 1867 }, "minX" : 1575, "maxX" : 1610, "minY" : 1846, "maxY" : 2148, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1607, "y" : 1846 }, "to" : { "x" : 1604, "y" : 1867 } }, { "from" : { "x" : 1604, "y" : 1867 }, "to" : { "x" : 1575, "y" : 2148 } } ], "endShape" : { "a" : { "x" : 1572, "y" : 2141 }, "b" : { "x" : 1575, "y" : 2148 }, "c" : { "x" : 1580, "y" : 2142 }, "type" : "ARROW", "centre" : { "x" : 1580, "y" : 2142 } }, "reactionShape" : { "a" : { "x" : 1598, "y" : 1861 }, "b" : { "x" : 1610, "y" : 1873 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1604, "y" : 1867 } }, "inputs" : [ { "id" : 105407 } ], "outputs" : [ { "id" : 105408 } ] } ], "compartments" : [ { "id" : 105541, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1205, "y" : 1006 }, "minX" : 331, "maxX" : 2079, "minY" : 120, "maxY" : 1893, "prop" : { "x" : 331, "y" : 120, "width" : 1748, "height" : 1773 }, "textPosition" : { "x" : 1874, "y" : 1781 }, "insets" : { "x" : 341, "y" : 130, "width" : 1728, "height" : 1753 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 105365, 105367, 105368, 105369, 105371, 105372, 105373, 105374, 105376, 105377, 105425, 105378, 105379, 105392, 105393, 105398, 105403, 105407, 105426, 105405, 105429, 105432, 105451, 105440, 105442, 105444, 105445, 105446, 105447, 105448, 105449, 105450, 105452, 105453, 105454, 105423, 105422, 105406, 105584, 105420, 105583, 105473, 105475, 105480, 105476, 105477, 105478, 105479, 105381, 105590, 105390, 105564, 105433, 105472, 105505, 105506, 105507, 105508, 105509, 105510, 105511, 105512, 105513, 105514, 105395, 105596, 105394, 105396, 105397, 105399, 105400, 105597, 105401, 105427, 105428, 105601, 105430, 105431, 105441, 105443, 105366, 105370, 105375, 105380, 105604, 105521, 105522, 105402, 105523, 105524, 105526, 105527, 105528, 105530, 105531, 105532, 105533, 105534, 105535, 105536, 105538, 105539, 105537, 105581, 105605 ] }, { "id" : 105540, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1194, "y" : 1536 }, "minX" : 0, "maxX" : 2389, "minY" : 0, "maxY" : 3073, "prop" : { "x" : 0, "y" : 0, "width" : 2389, "height" : 3073 }, "textPosition" : { "x" : 55, "y" : 3023 }, "insets" : { "x" : 10, "y" : 10, "width" : 2369, "height" : 3053 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 105384, 105359, 105360, 105362, 105364, 105382, 105383, 105385, 105386, 105387, 105388, 105409, 105413, 105416, 105414, 105415, 105417, 105418, 105419, 105542, 105408, 105435, 105424, 105582, 105585, 105391, 105541, 105456, 105458, 105459, 105460, 105586, 105587, 105458, 105482, 105550, 105461, 105468, 105470, 105471, 105462, 105474, 105481, 105485, 105412, 105588, 105589, 105389, 105421, 105567, 105591, 105593, 105594, 105486, 105489, 105488, 105490, 105492, 105493, 105494, 105495, 105496, 105497, 105498, 105499, 105500, 105502, 105503, 105504, 105487, 105465, 105463, 105491, 105592, 105434, 105437, 105436, 105438, 105595, 105411, 105410, 105404, 105572, 105464, 105501, 105515, 105516, 105517, 105518, 105519, 105520, 105361, 105602, 105603, 105363, 105525, 105483, 105484, 105529, 105598, 105599, 105600, 105598, 105600, 105599, 105439, 105455, 105457 ] }, { "id" : 105550, "reactomeId" : 20699, "displayName" : "Golgi membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 176, "y" : 2168 }, "minX" : 39, "maxX" : 314, "minY" : 2140, "maxY" : 2197, "prop" : { "x" : 39, "y" : 2140, "width" : 275, "height" : 57 }, "textPosition" : { "x" : 48, "y" : 2161 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 105466, 105467, 105469 ] } ], "notes" : [ ], "links" : [ { "id" : 105600, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 278, "y" : 1511 }, "minX" : 260, "maxX" : 297, "minY" : 1244, "maxY" : 1779, "segments" : [ { "from" : { "x" : 297, "y" : 1779 }, "to" : { "x" : 260, "y" : 1244 } } ], "reactionShape" : { "a" : { "x" : 272, "y" : 1505 }, "b" : { "x" : 284, "y" : 1517 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 278, "y" : 1511 } }, "inputs" : [ { "id" : 105572 } ], "outputs" : [ { "id" : 105383 } ] }, { "id" : 105603, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 145, "y" : 1149 }, "minX" : 128, "maxX" : 162, "minY" : 1143, "maxY" : 1155, "segments" : [ { "from" : { "x" : 128, "y" : 1155 }, "to" : { "x" : 162, "y" : 1143 } } ], "reactionShape" : { "a" : { "x" : 139, "y" : 1143 }, "b" : { "x" : 151, "y" : 1155 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 145, "y" : 1149 } }, "inputs" : [ { "id" : 105520 } ], "outputs" : [ { "id" : 105361 } ] }, { "id" : 105602, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 242, "y" : 1126 }, "minX" : 233, "maxX" : 251, "minY" : 1120, "maxY" : 1132, "segments" : [ { "from" : { "x" : 251, "y" : 1126 }, "to" : { "x" : 233, "y" : 1126 } } ], "reactionShape" : { "a" : { "x" : 236, "y" : 1120 }, "b" : { "x" : 248, "y" : 1132 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 242, "y" : 1126 } }, "inputs" : [ { "id" : 105517 } ], "outputs" : [ { "id" : 105361 } ] }, { "id" : 105605, "renderableClass" : "Interaction", "position" : { "x" : 1430, "y" : 1421 }, "minX" : 1364, "maxX" : 1445, "minY" : 1409, "maxY" : 1526, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1364, "y" : 1409 }, "to" : { "x" : 1430, "y" : 1421 } }, { "from" : { "x" : 1430, "y" : 1421 }, "to" : { "x" : 1445, "y" : 1526 } } ], "endShape" : { "a" : { "x" : 1440, "y" : 1520 }, "b" : { "x" : 1445, "y" : 1526 }, "c" : { "x" : 1448, "y" : 1519 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1448, "y" : 1519 } }, "reactionShape" : { "a" : { "x" : 1424, "y" : 1415 }, "b" : { "x" : 1436, "y" : 1427 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1430, "y" : 1421 } }, "inputs" : [ { "id" : 105581 } ], "outputs" : [ { "id" : 105381 } ] }, { "id" : 105583, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1585, "y" : 1399 }, "minX" : 1563, "maxX" : 1608, "minY" : 991, "maxY" : 1808, "segments" : [ { "from" : { "x" : 1608, "y" : 1808 }, "to" : { "x" : 1563, "y" : 991 } } ], "reactionShape" : { "a" : { "x" : 1579, "y" : 1393 }, "b" : { "x" : 1591, "y" : 1405 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1585, "y" : 1399 } }, "inputs" : [ { "id" : 105407 } ], "outputs" : [ { "id" : 105425 } ] }, { "id" : 105582, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1622, "y" : 2137 }, "minX" : 1599, "maxX" : 1645, "minY" : 2126, "maxY" : 2148, "segments" : [ { "from" : { "x" : 1599, "y" : 2148 }, "to" : { "x" : 1645, "y" : 2126 } } ], "reactionShape" : { "a" : { "x" : 1616, "y" : 2131 }, "b" : { "x" : 1628, "y" : 2143 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1622, "y" : 2137 } }, "inputs" : [ { "id" : 105408 } ], "outputs" : [ { "id" : 105424 } ] }, { "id" : 105585, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1952, "y" : 1969 }, "minX" : 1945, "maxX" : 1959, "minY" : 1963, "maxY" : 1975, "segments" : [ { "from" : { "x" : 1959, "y" : 1969 }, "to" : { "x" : 1945, "y" : 1969 } } ], "reactionShape" : { "a" : { "x" : 1946, "y" : 1963 }, "b" : { "x" : 1958, "y" : 1975 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1952, "y" : 1969 } }, "inputs" : [ { "id" : 105421 } ], "outputs" : [ { "id" : 105391 } ] }, { "id" : 105584, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1663, "y" : 1392 }, "minX" : 1565, "maxX" : 1762, "minY" : 991, "maxY" : 1794, "segments" : [ { "from" : { "x" : 1762, "y" : 1794 }, "to" : { "x" : 1565, "y" : 991 } } ], "reactionShape" : { "a" : { "x" : 1657, "y" : 1386 }, "b" : { "x" : 1669, "y" : 1398 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1663, "y" : 1392 } }, "inputs" : [ { "id" : 105451 } ], "outputs" : [ { "id" : 105425 } ] }, { "id" : 105587, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 967, "y" : 2388 }, "minX" : 900, "maxX" : 1350, "minY" : 2350, "maxY" : 2436, "segments" : [ { "from" : { "x" : 900, "y" : 2350 }, "to" : { "x" : 967, "y" : 2388 } }, { "from" : { "x" : 967, "y" : 2388 }, "to" : { "x" : 1350, "y" : 2436 } } ], "reactionShape" : { "a" : { "x" : 961, "y" : 2382 }, "b" : { "x" : 973, "y" : 2394 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 967, "y" : 2388 } }, "inputs" : [ { "id" : 105542 } ], "outputs" : [ { "id" : 105419 } ] }, { "id" : 105586, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1440, "y" : 2391 }, "minX" : 1409, "maxX" : 1472, "minY" : 2365, "maxY" : 2418, "segments" : [ { "from" : { "x" : 1472, "y" : 2365 }, "to" : { "x" : 1409, "y" : 2418 } } ], "reactionShape" : { "a" : { "x" : 1434, "y" : 2385 }, "b" : { "x" : 1446, "y" : 2397 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1440, "y" : 2391 } }, "inputs" : [ { "id" : 105416 } ], "outputs" : [ { "id" : 105419 } ] }, { "id" : 105589, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 1008, "y" : 2378 }, "minX" : 1002, "maxX" : 1421, "minY" : 2292, "maxY" : 2435, "segments" : [ { "from" : { "x" : 1421, "y" : 2292 }, "to" : { "x" : 1008, "y" : 2378 } }, { "from" : { "x" : 1008, "y" : 2378 }, "to" : { "x" : 1350, "y" : 2435 } } ], "reactionShape" : { "a" : { "x" : 1002, "y" : 2372 }, "b" : { "x" : 1014, "y" : 2384 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1008, "y" : 2378 } }, "inputs" : [ { "id" : 105412 } ], "outputs" : [ { "id" : 105419 } ] }, { "id" : 105588, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1484, "y" : 2313 }, "minX" : 1478, "maxX" : 1490, "minY" : 2305, "maxY" : 2321, "segments" : [ { "from" : { "x" : 1487, "y" : 2321 }, "to" : { "x" : 1481, "y" : 2305 } } ], "reactionShape" : { "a" : { "x" : 1478, "y" : 2307 }, "b" : { "x" : 1490, "y" : 2319 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1484, "y" : 2313 } }, "inputs" : [ { "id" : 105416 } ], "outputs" : [ { "id" : 105412 } ] }, { "id" : 105590, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1504, "y" : 1258 }, "minX" : 1449, "maxX" : 1560, "minY" : 991, "maxY" : 1526, "segments" : [ { "from" : { "x" : 1449, "y" : 1526 }, "to" : { "x" : 1560, "y" : 991 } } ], "reactionShape" : { "a" : { "x" : 1498, "y" : 1252 }, "b" : { "x" : 1510, "y" : 1264 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1504, "y" : 1258 } }, "inputs" : [ { "id" : 105381 } ], "outputs" : [ { "id" : 105425 } ] }, { "id" : 105592, "renderableClass" : "Interaction", "position" : { "x" : 2096, "y" : 1609 }, "minX" : 1773, "maxX" : 2102, "minY" : 1507, "maxY" : 2154, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2101, "y" : 2154 }, "to" : { "x" : 2096, "y" : 1609 } }, { "from" : { "x" : 2096, "y" : 1609 }, "to" : { "x" : 1773, "y" : 1507 } } ], "endShape" : { "a" : { "x" : 1781, "y" : 1505 }, "b" : { "x" : 1773, "y" : 1507 }, "c" : { "x" : 1778, "y" : 1513 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1778, "y" : 1513 } }, "reactionShape" : { "a" : { "x" : 2090, "y" : 1603 }, "b" : { "x" : 2102, "y" : 1615 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2096, "y" : 1609 } }, "inputs" : [ { "id" : 105567 } ], "outputs" : [ { "id" : 105564 } ] }, { "id" : 105595, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1707, "y" : 2011 }, "minX" : 1669, "maxX" : 1745, "minY" : 1931, "maxY" : 2092, "segments" : [ { "from" : { "x" : 1745, "y" : 1931 }, "to" : { "x" : 1669, "y" : 2092 } } ], "reactionShape" : { "a" : { "x" : 1701, "y" : 2005 }, "b" : { "x" : 1713, "y" : 2017 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1707, "y" : 2011 } }, "inputs" : [ { "id" : 105437 } ], "outputs" : [ { "id" : 105424 } ] }, { "id" : 105597, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1626, "y" : 1493 }, "minX" : 1431, "maxX" : 1821, "minY" : 1329, "maxY" : 1658, "segments" : [ { "from" : { "x" : 1431, "y" : 1329 }, "to" : { "x" : 1821, "y" : 1658 } } ], "reactionShape" : { "a" : { "x" : 1620, "y" : 1487 }, "b" : { "x" : 1632, "y" : 1499 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1626, "y" : 1493 } }, "inputs" : [ { "id" : 105400 } ], "outputs" : [ { "id" : 105392 } ] }, { "id" : 105596, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1262, "y" : 1276 }, "minX" : 1011, "maxX" : 1817, "minY" : 1266, "maxY" : 1658, "segments" : [ { "from" : { "x" : 1011, "y" : 1266 }, "to" : { "x" : 1262, "y" : 1276 } }, { "from" : { "x" : 1262, "y" : 1276 }, "to" : { "x" : 1817, "y" : 1658 } } ], "reactionShape" : { "a" : { "x" : 1256, "y" : 1270 }, "b" : { "x" : 1268, "y" : 1282 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1262, "y" : 1276 } }, "inputs" : [ { "id" : 105395 } ], "outputs" : [ { "id" : 105392 } ] }, { "id" : 105599, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1468, "y" : 1970 }, "minX" : 1462, "maxX" : 1474, "minY" : 1954, "maxY" : 1987, "segments" : [ { "from" : { "x" : 1468, "y" : 1954 }, "to" : { "x" : 1469, "y" : 1987 } } ], "reactionShape" : { "a" : { "x" : 1462, "y" : 1964 }, "b" : { "x" : 1474, "y" : 1976 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1468, "y" : 1970 } }, "inputs" : [ { "id" : 105404 } ], "outputs" : [ { "id" : 105411 } ] }, { "id" : 105598, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1675, "y" : 1951 }, "minX" : 1535, "maxX" : 1815, "minY" : 1938, "maxY" : 1964, "segments" : [ { "from" : { "x" : 1535, "y" : 1938 }, "to" : { "x" : 1815, "y" : 1964 } } ], "reactionShape" : { "a" : { "x" : 1669, "y" : 1945 }, "b" : { "x" : 1681, "y" : 1957 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1675, "y" : 1951 } }, "inputs" : [ { "id" : 105404 } ], "outputs" : [ { "id" : 105391 } ] } ], "shadows" : [ { "id" : 105607, "reactomeId" : 10911450, "displayName" : "G2 Phase", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 657, "y" : 657 }, "minX" : 375, "maxX" : 939, "minY" : 584, "maxY" : 730, "prop" : { "x" : 375, "y" : 584, "width" : 564, "height" : 146 }, "points" : [ { "x" : 375, "y" : 584 }, { "x" : 939, "y" : 584 }, { "x" : 939, "y" : 730 }, { "x" : 375, "y" : 730 } ], "colour" : "#dc3912" }, { "id" : 105606, "reactomeId" : 10911154, "displayName" : "G2/M Transition", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1160, "y" : 1635 }, "minX" : 17, "maxX" : 2304, "minY" : 302, "maxY" : 2969, "prop" : { "x" : 17, "y" : 730, "width" : 2287, "height" : 2239 }, "points" : [ { "x" : 17, "y" : 302 }, { "x" : 2304, "y" : 302 }, { "x" : 2304, "y" : 2969 }, { "x" : 17, "y" : 2969 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 2389, "minY" : 0, "maxY" : 3073, "disease" : false }