{ "dbId" : 390146, "stableId" : "R-DME-390146", "displayName" : "Hippo/Warts pathway", "nodes" : [ { "id" : 4, "reactomeId" : 351109, "displayName" : "FT", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 185, "y" : 267 }, "minX" : 173, "maxX" : 264, "minY" : 250, "maxY" : 278, "prop" : { "x" : 173, "y" : 256, "width" : 24, "height" : 22 }, "textPosition" : { "x" : 174, "y" : 256 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 197, "y" : 256 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 197, "y" : 256 } } }, "connectors" : [ { "edgeId" : 3, "type" : "INPUT", "segments" : [ { "from" : { "x" : 200, "y" : 264 }, "to" : { "x" : 264, "y" : 252 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 5, "reactomeId" : 351124, "displayName" : "DS", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 266, "y" : 305 }, "minX" : 253, "maxX" : 285, "minY" : 252, "maxY" : 316, "prop" : { "x" : 253, "y" : 294, "width" : 26, "height" : 22 }, "textPosition" : { "x" : 253, "y" : 294 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 279, "y" : 294 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 279, "y" : 294 } } }, "connectors" : [ { "edgeId" : 3, "type" : "INPUT", "segments" : [ { "from" : { "x" : 265, "y" : 291 }, "to" : { "x" : 264, "y" : 252 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 6, "reactomeId" : 350966, "displayName" : "DS:FT", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 266, "y" : 141 }, "minX" : 243, "maxX" : 295, "minY" : 60, "maxY" : 152, "prop" : { "x" : 243, "y" : 130, "width" : 46, "height" : 22 }, "textPosition" : { "x" : 244, "y" : 131 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 289, "y" : 130 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 289, "y" : 130 } } }, "connectors" : [ { "edgeId" : 3, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8, "type" : "INPUT", "segments" : [ { "from" : { "x" : 266, "y" : 127 }, "to" : { "x" : 266, "y" : 60 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9, "reactomeId" : 205729, "displayName" : "DCO", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 327, "y" : 98 }, "minX" : 266, "maxX" : 351, "minY" : 60, "maxY" : 109, "prop" : { "x" : 309, "y" : 87, "width" : 36, "height" : 22 }, "textPosition" : { "x" : 310, "y" : 87 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 345, "y" : 87 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 345, "y" : 87 } } }, "connectors" : [ { "edgeId" : 8, "type" : "INPUT", "segments" : [ { "from" : { "x" : 309, "y" : 84 }, "to" : { "x" : 266, "y" : 60 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 10, "reactomeId" : 451827, "displayName" : "DS:FT:DCO", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 415, "y" : 60 }, "minX" : 376, "maxX" : 500, "minY" : 14, "maxY" : 71, "prop" : { "x" : 376, "y" : 49, "width" : 79, "height" : 22 }, "textPosition" : { "x" : 379, "y" : 50 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 455, "y" : 49 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 455, "y" : 49 } } }, "connectors" : [ { "edgeId" : 8, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 11, "type" : "INPUT", "segments" : [ { "from" : { "x" : 458, "y" : 60 }, "to" : { "x" : 476, "y" : 60 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 11, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 415, "y" : 46 }, "to" : { "x" : 415, "y" : 14 } }, { "from" : { "x" : 415, "y" : 14 }, "to" : { "x" : 495, "y" : 14 } }, { "from" : { "x" : 495, "y" : 14 }, "to" : { "x" : 496, "y" : 44 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 496, "y" : 48 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 496, "y" : 48 } } } ] }, { "id" : 12, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 458, "y" : 108 }, "minX" : 439, "maxX" : 479, "minY" : 60, "maxY" : 123, "prop" : { "x" : 439, "y" : 93, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 443, "y" : 97 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 473, "y" : 98 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 473, "y" : 98 } } }, "connectors" : [ { "edgeId" : 11, "type" : "INPUT", "segments" : [ { "from" : { "x" : 463, "y" : 90 }, "to" : { "x" : 476, "y" : 60 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 555, "y" : 108 }, "minX" : 533, "maxX" : 577, "minY" : 59, "maxY" : 123, "prop" : { "x" : 534, "y" : 93, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 538, "y" : 97 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 571, "y" : 98 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 571, "y" : 98 } } }, "connectors" : [ { "edgeId" : 11, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 548, "y" : 90 }, "to" : { "x" : 533, "y" : 59 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 541, "y" : 86 }, "b" : { "x" : 548, "y" : 90 }, "c" : { "x" : 549, "y" : 82 }, "type" : "ARROW", "centre" : { "x" : 549, "y" : 82 } } } ] }, { "id" : 14, "reactomeId" : 451851, "displayName" : "DS:Phospho FT:DCO", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 623, "y" : 60 }, "minX" : 533, "maxX" : 972, "minY" : 0, "maxY" : 100, "prop" : { "x" : 569, "y" : 42, "width" : 109, "height" : 36 }, "textPosition" : { "x" : 570, "y" : 43 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 678, "y" : 42 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 678, "y" : 42 } } }, "connectors" : [ { "edgeId" : 11, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 566, "y" : 59 }, "to" : { "x" : 533, "y" : 59 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 559, "y" : 63 }, "b" : { "x" : 566, "y" : 59 }, "c" : { "x" : 559, "y" : 55 }, "type" : "ARROW", "centre" : { "x" : 559, "y" : 55 } } }, { "edgeId" : 15, "type" : "INPUT", "segments" : [ { "from" : { "x" : 681, "y" : 60 }, "to" : { "x" : 705, "y" : 60 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 629, "y" : 81 }, "to" : { "x" : 636, "y" : 99 } }, { "from" : { "x" : 636, "y" : 99 }, "to" : { "x" : 735, "y" : 100 } }, { "from" : { "x" : 735, "y" : 100 }, "to" : { "x" : 762, "y" : 60 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 635, "y" : 86 }, "b" : { "x" : 629, "y" : 81 }, "c" : { "x" : 628, "y" : 89 }, "type" : "ARROW", "centre" : { "x" : 628, "y" : 89 } } }, { "edgeId" : 87, "type" : "INPUT", "segments" : [ { "from" : { "x" : 647, "y" : 39 }, "to" : { "x" : 703, "y" : 0 } }, { "from" : { "x" : 703, "y" : 0 }, "to" : { "x" : 931, "y" : 0 } }, { "from" : { "x" : 931, "y" : 0 }, "to" : { "x" : 972, "y" : 60 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 16, "reactomeId" : 451889, "displayName" : "D", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 858, "y" : 60 }, "minX" : 705, "maxX" : 874, "minY" : 16, "maxY" : 168, "prop" : { "x" : 849, "y" : 49, "width" : 19, "height" : 22 }, "textPosition" : { "x" : 850, "y" : 49 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 868, "y" : 49 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 868, "y" : 49 } } }, "connectors" : [ { "edgeId" : 15, "type" : "INPUT", "segments" : [ { "from" : { "x" : 853, "y" : 46 }, "to" : { "x" : 842, "y" : 17 } }, { "from" : { "x" : 842, "y" : 17 }, "to" : { "x" : 720, "y" : 16 } }, { "from" : { "x" : 720, "y" : 16 }, "to" : { "x" : 705, "y" : 60 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 856, "y" : 74 }, "to" : { "x" : 844, "y" : 168 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 859, "y" : 81 }, "b" : { "x" : 856, "y" : 74 }, "c" : { "x" : 851, "y" : 80 }, "type" : "ARROW", "centre" : { "x" : 851, "y" : 80 } } } ] }, { "id" : 17, "reactomeId" : 390026, "displayName" : "D", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 782, "y" : 122 }, "minX" : 762, "maxX" : 798, "minY" : 60, "maxY" : 168, "prop" : { "x" : 773, "y" : 111, "width" : 19, "height" : 22 }, "textPosition" : { "x" : 774, "y" : 111 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 792, "y" : 111 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 792, "y" : 111 } } }, "connectors" : [ { "edgeId" : 15, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 778, "y" : 108 }, "to" : { "x" : 762, "y" : 60 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 772, "y" : 103 }, "b" : { "x" : 778, "y" : 108 }, "c" : { "x" : 780, "y" : 100 }, "type" : "ARROW", "centre" : { "x" : 780, "y" : 100 } } }, { "edgeId" : 93, "type" : "INPUT", "segments" : [ { "from" : { "x" : 783, "y" : 136 }, "to" : { "x" : 789, "y" : 168 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21, "reactomeId" : 390014, "displayName" : "SAV", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 391, "y" : 325 }, "minX" : 376, "maxX" : 413, "minY" : 278, "maxY" : 336, "prop" : { "x" : 376, "y" : 314, "width" : 31, "height" : 22 }, "textPosition" : { "x" : 379, "y" : 308 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 407, "y" : 314 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 407, "y" : 314 } } }, "connectors" : [ { "edgeId" : 20, "type" : "INPUT", "segments" : [ { "from" : { "x" : 390, "y" : 311 }, "to" : { "x" : 390, "y" : 278 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22, "reactomeId" : 390185, "displayName" : "HPO dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 349, "y" : 241 }, "minX" : 311, "maxX" : 393, "minY" : 200, "maxY" : 430, "prop" : { "x" : 311, "y" : 230, "width" : 76, "height" : 22 }, "textPosition" : { "x" : 312, "y" : 231 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 387, "y" : 230 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 387, "y" : 230 } } }, "connectors" : [ { "edgeId" : 67, "type" : "INPUT", "segments" : [ { "from" : { "x" : 348, "y" : 255 }, "to" : { "x" : 348, "y" : 430 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 83, "type" : "INPUT", "segments" : [ { "from" : { "x" : 356, "y" : 227 }, "to" : { "x" : 377, "y" : 200 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 20, "type" : "INPUT", "segments" : [ { "from" : { "x" : 361, "y" : 255 }, "to" : { "x" : 390, "y" : 278 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 23, "reactomeId" : 451812, "displayName" : "HPO dimer:SAV", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 488, "y" : 282 }, "minX" : 450, "maxX" : 577, "minY" : 259, "maxY" : 299, "prop" : { "x" : 450, "y" : 265, "width" : 77, "height" : 34 }, "textPosition" : { "x" : 450, "y" : 264 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 527, "y" : 265 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 527, "y" : 265 } } }, "connectors" : [ { "edgeId" : 20, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 24, "type" : "INPUT", "segments" : [ { "from" : { "x" : 530, "y" : 280 }, "to" : { "x" : 577, "y" : 279 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 25, "reactomeId" : 390037, "displayName" : "WTS", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 564, "y" : 237 }, "minX" : 547, "maxX" : 844, "minY" : 168, "maxY" : 430, "prop" : { "x" : 547, "y" : 226, "width" : 34, "height" : 22 }, "textPosition" : { "x" : 547, "y" : 226 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 581, "y" : 226 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 581, "y" : 226 } } }, "connectors" : [ { "edgeId" : 65, "type" : "INPUT", "segments" : [ { "from" : { "x" : 563, "y" : 251 }, "to" : { "x" : 563, "y" : 430 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 24, "type" : "INPUT", "segments" : [ { "from" : { "x" : 567, "y" : 251 }, "to" : { "x" : 577, "y" : 279 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93, "type" : "INPUT", "segments" : [ { "from" : { "x" : 563, "y" : 223 }, "to" : { "x" : 563, "y" : 215 } }, { "from" : { "x" : 563, "y" : 215 }, "to" : { "x" : 789, "y" : 168 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 584, "y" : 233 }, "to" : { "x" : 843, "y" : 182 } }, { "from" : { "x" : 843, "y" : 182 }, "to" : { "x" : 844, "y" : 168 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 590, "y" : 228 }, "b" : { "x" : 584, "y" : 233 }, "c" : { "x" : 592, "y" : 236 }, "type" : "ARROW", "centre" : { "x" : 592, "y" : 236 } } } ] }, { "id" : 26, "reactomeId" : 451836, "displayName" : "HPO dimer:SAV:WTS", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 680, "y" : 279 }, "minX" : 626, "maxX" : 761, "minY" : 255, "maxY" : 297, "prop" : { "x" : 626, "y" : 261, "width" : 109, "height" : 36 }, "textPosition" : { "x" : 628, "y" : 262 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 735, "y" : 261 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 735, "y" : 261 } } }, "connectors" : [ { "edgeId" : 24, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 27, "type" : "INPUT", "segments" : [ { "from" : { "x" : 738, "y" : 279 }, "to" : { "x" : 761, "y" : 279 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 28, "reactomeId" : 390158, "displayName" : "MATS", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 752, "y" : 233 }, "minX" : 732, "maxX" : 779, "minY" : 216, "maxY" : 279, "prop" : { "x" : 732, "y" : 222, "width" : 41, "height" : 22 }, "textPosition" : { "x" : 732, "y" : 222 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 773, "y" : 222 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 773, "y" : 222 } } }, "connectors" : [ { "edgeId" : 27, "type" : "INPUT", "segments" : [ { "from" : { "x" : 754, "y" : 247 }, "to" : { "x" : 761, "y" : 279 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 29, "reactomeId" : 451805, "displayName" : "MATS:HPO dimer:SAV:WTS", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 881, "y" : 280 }, "minX" : 822, "maxX" : 1007, "minY" : 256, "maxY" : 320, "prop" : { "x" : 822, "y" : 262, "width" : 119, "height" : 36 }, "textPosition" : { "x" : 824, "y" : 263 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 941, "y" : 262 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 941, "y" : 262 } } }, "connectors" : [ { "edgeId" : 27, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 30, "type" : "INPUT", "segments" : [ { "from" : { "x" : 944, "y" : 280 }, "to" : { "x" : 964, "y" : 280 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 30, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 880, "y" : 301 }, "to" : { "x" : 879, "y" : 320 } }, { "from" : { "x" : 879, "y" : 320 }, "to" : { "x" : 1003, "y" : 320 } }, { "from" : { "x" : 1003, "y" : 320 }, "to" : { "x" : 1003, "y" : 296 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1003, "y" : 292 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1003, "y" : 292 } } } ] }, { "id" : 31, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 944, "y" : 221 }, "minX" : 925, "maxX" : 965, "minY" : 205, "maxY" : 280, "prop" : { "x" : 925, "y" : 206, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 929, "y" : 210 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 959, "y" : 211 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 959, "y" : 211 } } }, "connectors" : [ { "edgeId" : 30, "type" : "INPUT", "segments" : [ { "from" : { "x" : 949, "y" : 239 }, "to" : { "x" : 964, "y" : 280 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 950, "y" : 253 }, "b" : { "x" : 962, "y" : 265 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 956, "y" : 259 } } } } ] }, { "id" : 32, "reactomeId" : 451829, "displayName" : "MATS:Phospho HPO dimer:SAV:WTS", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1136, "y" : 280 }, "minX" : 1035, "maxX" : 1266, "minY" : 249, "maxY" : 330, "prop" : { "x" : 1082, "y" : 255, "width" : 109, "height" : 50 }, "textPosition" : { "x" : 1084, "y" : 256 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1191, "y" : 255 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1191, "y" : 255 } } }, "connectors" : [ { "edgeId" : 30, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1079, "y" : 279 }, "to" : { "x" : 1035, "y" : 279 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1072, "y" : 283 }, "b" : { "x" : 1079, "y" : 279 }, "c" : { "x" : 1072, "y" : 275 }, "type" : "ARROW", "centre" : { "x" : 1072, "y" : 275 } } }, { "edgeId" : 34, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1194, "y" : 281 }, "to" : { "x" : 1222, "y" : 282 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1136, "y" : 308 }, "to" : { "x" : 1136, "y" : 330 } }, { "from" : { "x" : 1136, "y" : 330 }, "to" : { "x" : 1260, "y" : 328 } }, { "from" : { "x" : 1260, "y" : 328 }, "to" : { "x" : 1262, "y" : 298 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1262, "y" : 294 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1262, "y" : 294 } } } ] }, { "id" : 33, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1066, "y" : 221 }, "minX" : 1035, "maxX" : 1088, "minY" : 205, "maxY" : 279, "prop" : { "x" : 1045, "y" : 206, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 1049, "y" : 210 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1082, "y" : 211 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1082, "y" : 211 } } }, "connectors" : [ { "edgeId" : 30, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1057, "y" : 239 }, "to" : { "x" : 1035, "y" : 279 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1040, "y" : 253 }, "b" : { "x" : 1052, "y" : 265 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1046, "y" : 259 } } }, "endShape" : { "a" : { "x" : 1057, "y" : 247 }, "b" : { "x" : 1057, "y" : 239 }, "c" : { "x" : 1050, "y" : 243 }, "type" : "ARROW", "centre" : { "x" : 1050, "y" : 243 } } } ] }, { "id" : 35, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1204, "y" : 221 }, "minX" : 1185, "maxX" : 1225, "minY" : 205, "maxY" : 282, "prop" : { "x" : 1185, "y" : 206, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 1189, "y" : 210 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1219, "y" : 211 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1219, "y" : 211 } } }, "connectors" : [ { "edgeId" : 34, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1208, "y" : 239 }, "to" : { "x" : 1222, "y" : 282 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 36, "reactomeId" : 451860, "displayName" : "MATS:Phospho HPO dimer:Phospho SAV:WTS", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1404, "y" : 283 }, "minX" : 1304, "maxX" : 1502, "minY" : 252, "maxY" : 331, "prop" : { "x" : 1345, "y" : 258, "width" : 119, "height" : 50 }, "textPosition" : { "x" : 1352, "y" : 245 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1464, "y" : 258 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1464, "y" : 258 } } }, "connectors" : [ { "edgeId" : 34, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1342, "y" : 282 }, "to" : { "x" : 1304, "y" : 282 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1335, "y" : 286 }, "b" : { "x" : 1342, "y" : 282 }, "c" : { "x" : 1335, "y" : 278 }, "type" : "ARROW", "centre" : { "x" : 1335, "y" : 278 } } }, { "edgeId" : 38, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1467, "y" : 281 }, "to" : { "x" : 1502, "y" : 280 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1402, "y" : 311 }, "to" : { "x" : 1402, "y" : 328 } }, { "from" : { "x" : 1402, "y" : 328 }, "to" : { "x" : 1488, "y" : 327 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1492, "y" : 327 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1492, "y" : 327 } } } ] }, { "id" : 37, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1329, "y" : 223 }, "minX" : 1304, "maxX" : 1351, "minY" : 207, "maxY" : 282, "prop" : { "x" : 1308, "y" : 208, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 1312, "y" : 212 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1345, "y" : 213 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1345, "y" : 213 } } }, "connectors" : [ { "edgeId" : 34, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1322, "y" : 241 }, "to" : { "x" : 1304, "y" : 282 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1323, "y" : 249 }, "b" : { "x" : 1322, "y" : 241 }, "c" : { "x" : 1316, "y" : 246 }, "type" : "ARROW", "centre" : { "x" : 1316, "y" : 246 } } } ] }, { "id" : 39, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1472, "y" : 226 }, "minX" : 1453, "maxX" : 1502, "minY" : 210, "maxY" : 280, "prop" : { "x" : 1453, "y" : 211, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 1457, "y" : 215 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1487, "y" : 216 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1487, "y" : 216 } } }, "connectors" : [ { "edgeId" : 38, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1480, "y" : 244 }, "to" : { "x" : 1502, "y" : 280 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 40, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1527, "y" : 449 }, "minX" : 1503, "maxX" : 1549, "minY" : 358, "maxY" : 464, "prop" : { "x" : 1506, "y" : 434, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 1510, "y" : 438 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1543, "y" : 439 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1543, "y" : 439 } } }, "connectors" : [ { "edgeId" : 38, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1523, "y" : 431 }, "to" : { "x" : 1503, "y" : 358 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1517, "y" : 425 }, "b" : { "x" : 1523, "y" : 431 }, "c" : { "x" : 1525, "y" : 423 }, "type" : "ARROW", "centre" : { "x" : 1525, "y" : 423 } } } ] }, { "id" : 41, "reactomeId" : 390172, "displayName" : "MATS:Phospho HPO dimer:Phospho SAV:Phospho WTS", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1408, "y" : 525 }, "minX" : 1274, "maxX" : 1503, "minY" : 358, "maxY" : 578, "prop" : { "x" : 1356, "y" : 493, "width" : 104, "height" : 64 }, "textPosition" : { "x" : 1356, "y" : 494 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1460, "y" : 493 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1460, "y" : 493 } } }, "connectors" : [ { "edgeId" : 38, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1426, "y" : 490 }, "to" : { "x" : 1503, "y" : 358 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1426, "y" : 482 }, "b" : { "x" : 1426, "y" : 490 }, "c" : { "x" : 1433, "y" : 486 }, "type" : "ARROW", "centre" : { "x" : 1433, "y" : 486 } } }, { "edgeId" : 44, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1353, "y" : 526 }, "to" : { "x" : 1313, "y" : 527 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1409, "y" : 560 }, "to" : { "x" : 1410, "y" : 578 } }, { "from" : { "x" : 1410, "y" : 578 }, "to" : { "x" : 1278, "y" : 578 } }, { "from" : { "x" : 1278, "y" : 578 }, "to" : { "x" : 1278, "y" : 543 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1278, "y" : 539 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1278, "y" : 539 } } } ] }, { "id" : 45, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1357, "y" : 465 }, "minX" : 1313, "maxX" : 1378, "minY" : 449, "maxY" : 527, "prop" : { "x" : 1338, "y" : 450, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 1342, "y" : 454 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1372, "y" : 455 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1372, "y" : 455 } } }, "connectors" : [ { "edgeId" : 44, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1346, "y" : 483 }, "to" : { "x" : 1313, "y" : 527 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 46, "reactomeId" : 390134, "displayName" : "Phospho HPO dimer:Phospho SAV:Phospho WTS:Phospho MATS", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1131, "y" : 531 }, "minX" : 995, "maxX" : 1240, "minY" : 493, "maxY" : 590, "prop" : { "x" : 1069, "y" : 499, "width" : 124, "height" : 64 }, "textPosition" : { "x" : 1078, "y" : 486 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1193, "y" : 499 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1193, "y" : 499 } } }, "connectors" : [ { "edgeId" : 44, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1196, "y" : 529 }, "to" : { "x" : 1240, "y" : 528 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1203, "y" : 525 }, "b" : { "x" : 1196, "y" : 529 }, "c" : { "x" : 1203, "y" : 533 }, "type" : "ARROW", "centre" : { "x" : 1203, "y" : 533 } } }, { "edgeId" : 48, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1066, "y" : 532 }, "to" : { "x" : 1033, "y" : 533 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 48, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1128, "y" : 566 }, "to" : { "x" : 1126, "y" : 589 } }, { "from" : { "x" : 1126, "y" : 589 }, "to" : { "x" : 999, "y" : 590 } }, { "from" : { "x" : 999, "y" : 590 }, "to" : { "x" : 999, "y" : 549 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 999, "y" : 545 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 999, "y" : 545 } } } ] }, { "id" : 47, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1216, "y" : 465 }, "minX" : 1195, "maxX" : 1240, "minY" : 449, "maxY" : 528, "prop" : { "x" : 1195, "y" : 450, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 1199, "y" : 454 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1232, "y" : 455 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1232, "y" : 455 } } }, "connectors" : [ { "edgeId" : 44, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1221, "y" : 483 }, "to" : { "x" : 1240, "y" : 528 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1227, "y" : 488 }, "b" : { "x" : 1221, "y" : 483 }, "c" : { "x" : 1220, "y" : 491 }, "type" : "ARROW", "centre" : { "x" : 1220, "y" : 491 } } } ] }, { "id" : 49, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1066, "y" : 465 }, "minX" : 1033, "maxX" : 1087, "minY" : 449, "maxY" : 533, "prop" : { "x" : 1047, "y" : 450, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 1051, "y" : 454 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1081, "y" : 455 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1081, "y" : 455 } } }, "connectors" : [ { "edgeId" : 48, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1058, "y" : 483 }, "to" : { "x" : 1033, "y" : 533 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 50, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 934, "y" : 477 }, "minX" : 913, "maxX" : 957, "minY" : 461, "maxY" : 533, "prop" : { "x" : 913, "y" : 462, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 917, "y" : 466 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 950, "y" : 467 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 950, "y" : 467 } } }, "connectors" : [ { "edgeId" : 48, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 940, "y" : 495 }, "to" : { "x" : 957, "y" : 533 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 946, "y" : 500 }, "b" : { "x" : 940, "y" : 495 }, "c" : { "x" : 939, "y" : 503 }, "type" : "ARROW", "centre" : { "x" : 939, "y" : 503 } } } ] }, { "id" : 51, "reactomeId" : 390068, "displayName" : "Phospho HPO dimer:Phospho SAV:Phospho (2 sites) WTS:Phospho MATS", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 832, "y" : 534 }, "minX" : 693, "maxX" : 957, "minY" : 427, "maxY" : 598, "prop" : { "x" : 777, "y" : 495, "width" : 111, "height" : 78 }, "textPosition" : { "x" : 777, "y" : 496 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 888, "y" : 495 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 888, "y" : 495 } } }, "connectors" : [ { "edgeId" : 77, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 831, "y" : 492 }, "to" : { "x" : 830, "y" : 435 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 830, "y" : 431 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 830, "y" : 431 } } }, { "edgeId" : 48, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 891, "y" : 533 }, "to" : { "x" : 957, "y" : 533 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 898, "y" : 529 }, "b" : { "x" : 891, "y" : 533 }, "c" : { "x" : 898, "y" : 537 }, "type" : "ARROW", "centre" : { "x" : 898, "y" : 537 } } }, { "edgeId" : 54, "type" : "INPUT", "segments" : [ { "from" : { "x" : 774, "y" : 543 }, "to" : { "x" : 693, "y" : 557 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 58, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 830, "y" : 576 }, "to" : { "x" : 829, "y" : 598 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 834, "y" : 583 }, "b" : { "x" : 830, "y" : 576 }, "c" : { "x" : 826, "y" : 583 }, "type" : "ARROW", "centre" : { "x" : 826, "y" : 583 } } } ] }, { "id" : 56, "reactomeId" : 390067, "displayName" : "Phospho HPO dimer:Phospho SAV:Phospho (2 sites) WTS:YKI:Phospho MATS", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 726, "y" : 714 }, "minX" : 671, "maxX" : 830, "minY" : 635, "maxY" : 753, "prop" : { "x" : 671, "y" : 675, "width" : 111, "height" : 78 }, "textPosition" : { "x" : 671, "y" : 676 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 782, "y" : 675 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 782, "y" : 675 } } }, "connectors" : [ { "edgeId" : 54, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 58, "type" : "INPUT", "segments" : [ { "from" : { "x" : 785, "y" : 696 }, "to" : { "x" : 830, "y" : 681 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 58, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 726, "y" : 672 }, "to" : { "x" : 726, "y" : 639 } }, { "from" : { "x" : 726, "y" : 639 }, "to" : { "x" : 813, "y" : 639 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 817, "y" : 639 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 817, "y" : 639 } } } ] }, { "id" : 59, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 877, "y" : 730 }, "minX" : 830, "maxX" : 898, "minY" : 681, "maxY" : 745, "prop" : { "x" : 858, "y" : 715, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 862, "y" : 719 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 892, "y" : 720 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 892, "y" : 720 } } }, "connectors" : [ { "edgeId" : 58, "type" : "INPUT", "segments" : [ { "from" : { "x" : 862, "y" : 712 }, "to" : { "x" : 830, "y" : 681 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 840, "y" : 690 }, "b" : { "x" : 852, "y" : 702 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 846, "y" : 696 } } } } ] }, { "id" : 60, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 915, "y" : 601 }, "minX" : 829, "maxX" : 937, "minY" : 585, "maxY" : 616, "prop" : { "x" : 894, "y" : 586, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 898, "y" : 590 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 931, "y" : 591 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 931, "y" : 591 } } }, "connectors" : [ { "edgeId" : 58, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 891, "y" : 600 }, "to" : { "x" : 829, "y" : 598 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 854, "y" : 593 }, "b" : { "x" : 866, "y" : 605 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 860, "y" : 599 } } }, "endShape" : { "a" : { "x" : 884, "y" : 604 }, "b" : { "x" : 891, "y" : 600 }, "c" : { "x" : 884, "y" : 596 }, "type" : "ARROW", "centre" : { "x" : 884, "y" : 596 } } } ] }, { "id" : 61, "reactomeId" : 390064, "displayName" : "Phospho YKI", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 975, "y" : 673 }, "minX" : 829, "maxX" : 1023, "minY" : 598, "maxY" : 729, "prop" : { "x" : 933, "y" : 662, "width" : 84, "height" : 22 }, "innerProp" : { "x" : 939, "y" : 662, "width" : 78, "height" : 16 }, "textPosition" : { "x" : 933, "y" : 662 }, "nodeAttachments" : [ { "reactomeId" : 390166, "label" : "P", "description" : "O-phospho-L-serine at 168", "shape" : { "a" : { "x" : 1010, "y" : 678 }, "b" : { "x" : 1022, "y" : 690 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1016, "y" : 684 } } }, { "reactomeId" : 451859, "label" : "P", "description" : "O-phospho-L-serine at 111", "shape" : { "a" : { "x" : 927, "y" : 676 }, "b" : { "x" : 939, "y" : 688 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 933, "y" : 682 } } }, { "reactomeId" : 451890, "label" : "P", "description" : "O-phospho-L-serine at 250", "shape" : { "a" : { "x" : 928, "y" : 668 }, "b" : { "x" : 940, "y" : 680 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 934, "y" : 674 } } } ], "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1017, "y" : 662 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1017, "y" : 662 } } }, "connectors" : [ { "edgeId" : 58, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 953, "y" : 659 }, "to" : { "x" : 829, "y" : 598 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 945, "y" : 660 }, "b" : { "x" : 953, "y" : 659 }, "c" : { "x" : 949, "y" : 652 }, "type" : "ARROW", "centre" : { "x" : 949, "y" : 652 } } }, { "edgeId" : 62, "type" : "INPUT", "segments" : [ { "from" : { "x" : 975, "y" : 687 }, "to" : { "x" : 975, "y" : 729 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 63, "reactomeId" : 390066, "displayName" : "14-3-3 dimer", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1066, "y" : 708 }, "minX" : 975, "maxX" : 1113, "minY" : 697, "maxY" : 729, "prop" : { "x" : 1019, "y" : 697, "width" : 94, "height" : 22 }, "textPosition" : { "x" : 1022, "y" : 697 }, "connectors" : [ { "edgeId" : 62, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1013, "y" : 718 }, "to" : { "x" : 975, "y" : 729 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 64, "reactomeId" : 390163, "displayName" : "14-3-3 dimer:Phospho YKI", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 975, "y" : 816 }, "minX" : 926, "maxX" : 1031, "minY" : 792, "maxY" : 834, "prop" : { "x" : 926, "y" : 798, "width" : 99, "height" : 36 }, "textPosition" : { "x" : 930, "y" : 799 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1025, "y" : 798 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1025, "y" : 798 } } }, "connectors" : [ { "edgeId" : 62, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 66, "reactomeId" : 451862, "displayName" : "WTS:YKI", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 565, "y" : 522 }, "minX" : 537, "maxX" : 599, "minY" : 505, "maxY" : 533, "prop" : { "x" : 537, "y" : 511, "width" : 56, "height" : 22 }, "textPosition" : { "x" : 537, "y" : 512 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 593, "y" : 511 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 593, "y" : 511 } } }, "connectors" : [ { "edgeId" : 65, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 68, "reactomeId" : 451843, "displayName" : "HPO dimer:YKI", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 350, "y" : 520 }, "minX" : 301, "maxX" : 406, "minY" : 503, "maxY" : 531, "prop" : { "x" : 301, "y" : 509, "width" : 99, "height" : 22 }, "textPosition" : { "x" : 303, "y" : 510 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 400, "y" : 509 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 400, "y" : 509 } } }, "connectors" : [ { "edgeId" : 67, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 70, "reactomeId" : 451874, "displayName" : "EX", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 265, "y" : 613 }, "minX" : 253, "maxX" : 451, "minY" : 596, "maxY" : 624, "prop" : { "x" : 253, "y" : 602, "width" : 24, "height" : 22 }, "textPosition" : { "x" : 253, "y" : 602 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 277, "y" : 602 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 277, "y" : 602 } } }, "connectors" : [ { "edgeId" : 69, "type" : "INPUT", "segments" : [ { "from" : { "x" : 280, "y" : 612 }, "to" : { "x" : 451, "y" : 611 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 71, "reactomeId" : 451822, "displayName" : "EX:YKI", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 261, "y" : 697 }, "minX" : 238, "maxX" : 290, "minY" : 680, "maxY" : 708, "prop" : { "x" : 238, "y" : 686, "width" : 46, "height" : 22 }, "textPosition" : { "x" : 239, "y" : 687 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 284, "y" : 686 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 284, "y" : 686 } } }, "connectors" : [ { "edgeId" : 69, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 72, "reactomeId" : 390114, "displayName" : "YKI", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 450, "y" : 564 }, "minX" : 348, "maxX" : 693, "minY" : 430, "maxY" : 611, "prop" : { "x" : 437, "y" : 553, "width" : 26, "height" : 22 }, "textPosition" : { "x" : 437, "y" : 553 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 463, "y" : 553 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 463, "y" : 553 } } }, "connectors" : [ { "edgeId" : 65, "type" : "INPUT", "segments" : [ { "from" : { "x" : 459, "y" : 550 }, "to" : { "x" : 563, "y" : 430 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 67, "type" : "INPUT", "segments" : [ { "from" : { "x" : 441, "y" : 550 }, "to" : { "x" : 348, "y" : 430 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 69, "type" : "INPUT", "segments" : [ { "from" : { "x" : 450, "y" : 578 }, "to" : { "x" : 451, "y" : 611 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 97, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 54, "type" : "INPUT", "segments" : [ { "from" : { "x" : 466, "y" : 563 }, "to" : { "x" : 693, "y" : 557 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 78, "reactomeId" : 390182, "displayName" : "TH", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 737, "y" : 418 }, "minX" : 724, "maxX" : 803, "minY" : 401, "maxY" : 429, "prop" : { "x" : 724, "y" : 407, "width" : 26, "height" : 22 }, "textPosition" : { "x" : 725, "y" : 407 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 750, "y" : 407 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 750, "y" : 407 } } }, "connectors" : [ { "edgeId" : 77, "type" : "INPUT", "segments" : [ { "from" : { "x" : 753, "y" : 418 }, "to" : { "x" : 803, "y" : 419 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 79, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 763, "y" : 374 }, "minX" : 744, "maxX" : 803, "minY" : 358, "maxY" : 419, "prop" : { "x" : 744, "y" : 359, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 748, "y" : 363 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 778, "y" : 364 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 778, "y" : 364 } } }, "connectors" : [ { "edgeId" : 77, "type" : "INPUT", "segments" : [ { "from" : { "x" : 776, "y" : 392 }, "to" : { "x" : 803, "y" : 419 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80, "reactomeId" : 390103, "displayName" : "Phospho TH", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 931, "y" : 418 }, "minX" : 856, "maxX" : 979, "minY" : 401, "maxY" : 429, "prop" : { "x" : 889, "y" : 407, "width" : 84, "height" : 22 }, "innerProp" : { "x" : 889, "y" : 413, "width" : 84, "height" : 16 }, "textPosition" : { "x" : 889, "y" : 407 }, "nodeAttachments" : [ { "reactomeId" : 390176, "label" : "P", "description" : "phosphorylated residue at unknown position", "shape" : { "a" : { "x" : 899, "y" : 401 }, "b" : { "x" : 911, "y" : 413 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 905, "y" : 407 } } } ], "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 973, "y" : 407 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 973, "y" : 407 } } }, "connectors" : [ { "edgeId" : 77, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 886, "y" : 418 }, "to" : { "x" : 856, "y" : 419 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 879, "y" : 422 }, "b" : { "x" : 886, "y" : 418 }, "c" : { "x" : 879, "y" : 414 }, "type" : "ARROW", "centre" : { "x" : 879, "y" : 414 } } } ] }, { "id" : 81, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 892, "y" : 367 }, "minX" : 856, "maxX" : 914, "minY" : 351, "maxY" : 419, "prop" : { "x" : 871, "y" : 352, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 875, "y" : 356 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 908, "y" : 357 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 908, "y" : 357 } } }, "connectors" : [ { "edgeId" : 77, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 881, "y" : 385 }, "to" : { "x" : 856, "y" : 419 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 880, "y" : 393 }, "b" : { "x" : 881, "y" : 385 }, "c" : { "x" : 874, "y" : 388 }, "type" : "ARROW", "centre" : { "x" : 874, "y" : 388 } } } ] }, { "id" : 84, "reactomeId" : 390054, "displayName" : "RASSF", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 320, "y" : 192 }, "minX" : 297, "maxX" : 377, "minY" : 175, "maxY" : 203, "prop" : { "x" : 297, "y" : 181, "width" : 46, "height" : 22 }, "textPosition" : { "x" : 300, "y" : 175 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 343, "y" : 181 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 343, "y" : 181 } } }, "connectors" : [ { "edgeId" : 83, "type" : "INPUT", "segments" : [ { "from" : { "x" : 346, "y" : 195 }, "to" : { "x" : 377, "y" : 200 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 85, "reactomeId" : 390177, "displayName" : "HPO dimer:RASSF", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 482, "y" : 204 }, "minX" : 442, "maxX" : 529, "minY" : 180, "maxY" : 222, "prop" : { "x" : 442, "y" : 186, "width" : 81, "height" : 36 }, "textPosition" : { "x" : 444, "y" : 187 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 523, "y" : 186 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 523, "y" : 186 } } }, "connectors" : [ { "edgeId" : 83, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 88, "reactomeId" : 451871, "displayName" : "LFT", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 952, "y" : 118 }, "minX" : 937, "maxX" : 974, "minY" : 60, "maxY" : 129, "prop" : { "x" : 937, "y" : 107, "width" : 31, "height" : 22 }, "textPosition" : { "x" : 938, "y" : 107 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 968, "y" : 107 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 968, "y" : 107 } } }, "connectors" : [ { "edgeId" : 87, "type" : "INPUT", "segments" : [ { "from" : { "x" : 955, "y" : 104 }, "to" : { "x" : 972, "y" : 60 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 957, "y" : 76 }, "b" : { "x" : 969, "y" : 88 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 963, "y" : 82 } } } } ] }, { "id" : 89, "reactomeId" : 451879, "displayName" : "LFT:DS:Phospho FT:LFT:DCO", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1092, "y" : 61 }, "minX" : 1034, "maxX" : 1156, "minY" : 37, "maxY" : 79, "prop" : { "x" : 1034, "y" : 43, "width" : 116, "height" : 36 }, "textPosition" : { "x" : 1036, "y" : 44 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1150, "y" : 43 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1150, "y" : 43 } } }, "connectors" : [ { "edgeId" : 87, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98, "reactomeId" : 390143, "displayName" : "YKI", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 495, "y" : 837 }, "minX" : 482, "maxX" : 582, "minY" : 820, "maxY" : 987, "prop" : { "x" : 482, "y" : 826, "width" : 26, "height" : 22 }, "textPosition" : { "x" : 482, "y" : 826 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 508, "y" : 826 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 508, "y" : 826 } } }, "connectors" : [ { "edgeId" : 97, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99, "type" : "INPUT", "segments" : [ { "from" : { "x" : 496, "y" : 851 }, "to" : { "x" : 516, "y" : 987 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 102, "type" : "INPUT", "segments" : [ { "from" : { "x" : 511, "y" : 846 }, "to" : { "x" : 548, "y" : 874 } }, { "from" : { "x" : 548, "y" : 874 }, "to" : { "x" : 582, "y" : 873 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100, "reactomeId" : 390187, "displayName" : "SD", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 475, "y" : 988 }, "minX" : 462, "maxX" : 516, "minY" : 971, "maxY" : 999, "prop" : { "x" : 462, "y" : 977, "width" : 26, "height" : 22 }, "textPosition" : { "x" : 462, "y" : 977 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 488, "y" : 977 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 488, "y" : 977 } } }, "connectors" : [ { "edgeId" : 99, "type" : "INPUT", "segments" : [ { "from" : { "x" : 491, "y" : 987 }, "to" : { "x" : 516, "y" : 987 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 101, "reactomeId" : 390092, "displayName" : "YKI:SD", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 603, "y" : 987 }, "minX" : 579, "maxX" : 634, "minY" : 970, "maxY" : 998, "prop" : { "x" : 579, "y" : 976, "width" : 49, "height" : 22 }, "textPosition" : { "x" : 580, "y" : 977 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 628, "y" : 976 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 628, "y" : 976 } } }, "connectors" : [ { "edgeId" : 99, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 103, "reactomeId" : 451832, "displayName" : "TSH", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 560, "y" : 907 }, "minX" : 543, "maxX" : 583, "minY" : 873, "maxY" : 918, "prop" : { "x" : 543, "y" : 896, "width" : 34, "height" : 22 }, "textPosition" : { "x" : 544, "y" : 896 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 577, "y" : 896 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 577, "y" : 896 } } }, "connectors" : [ { "edgeId" : 102, "type" : "INPUT", "segments" : [ { "from" : { "x" : 567, "y" : 893 }, "to" : { "x" : 582, "y" : 873 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 104, "reactomeId" : 451881, "displayName" : "HTH", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 560, "y" : 836 }, "minX" : 542, "maxX" : 584, "minY" : 819, "maxY" : 873, "prop" : { "x" : 542, "y" : 825, "width" : 36, "height" : 22 }, "textPosition" : { "x" : 543, "y" : 825 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 578, "y" : 825 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 578, "y" : 825 } } }, "connectors" : [ { "edgeId" : 102, "type" : "INPUT", "segments" : [ { "from" : { "x" : 566, "y" : 850 }, "to" : { "x" : 582, "y" : 873 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 105, "reactomeId" : 451887, "displayName" : "HTH:YKI:TSH", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 705, "y" : 874 }, "minX" : 661, "maxX" : 756, "minY" : 857, "maxY" : 885, "prop" : { "x" : 661, "y" : 863, "width" : 89, "height" : 22 }, "textPosition" : { "x" : 664, "y" : 864 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 750, "y" : 863 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 750, "y" : 863 } } }, "connectors" : [ { "edgeId" : 102, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 65, "reactomeId" : 451811, "displayName" : "YKI binds to WTS", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 563, "y" : 472 }, "minX" : 558, "maxX" : 568, "minY" : 430, "maxY" : 508, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 563, "y" : 430 }, "to" : { "x" : 563, "y" : 472 } }, { "from" : { "x" : 563, "y" : 472 }, "to" : { "x" : 564, "y" : 508 } } ], "endShape" : { "a" : { "x" : 560, "y" : 501 }, "b" : { "x" : 564, "y" : 508 }, "c" : { "x" : 568, "y" : 501 }, "type" : "ARROW", "centre" : { "x" : 568, "y" : 501 } }, "reactionShape" : { "c" : { "x" : 563, "y" : 472 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 563, "y" : 472 } }, "inputs" : [ { "id" : 25, "points" : [ { "x" : 563, "y" : 251 } ] }, { "id" : 72, "points" : [ { "x" : 459, "y" : 550 } ] } ], "outputs" : [ { "id" : 66 } ] }, { "id" : 3, "reactomeId" : 350440, "displayName" : "FT binds to DS in an adjacent cell", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 265, "y" : 214 }, "minX" : 260, "maxX" : 270, "minY" : 155, "maxY" : 252, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 264, "y" : 252 }, "to" : { "x" : 265, "y" : 214 } }, { "from" : { "x" : 265, "y" : 214 }, "to" : { "x" : 265, "y" : 155 } } ], "endShape" : { "a" : { "x" : 269, "y" : 162 }, "b" : { "x" : 265, "y" : 155 }, "c" : { "x" : 261, "y" : 162 }, "type" : "ARROW", "centre" : { "x" : 261, "y" : 162 } }, "reactionShape" : { "c" : { "x" : 265, "y" : 214 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 265, "y" : 214 } }, "inputs" : [ { "id" : 4, "points" : [ { "x" : 200, "y" : 264 } ] }, { "id" : 5, "points" : [ { "x" : 265, "y" : 291 } ] } ], "outputs" : [ { "id" : 6 } ] }, { "id" : 67, "reactomeId" : 451858, "displayName" : "YKI binds to HPO homodimer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 347, "y" : 468 }, "minX" : 342, "maxX" : 352, "minY" : 430, "maxY" : 506, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 348, "y" : 430 }, "to" : { "x" : 347, "y" : 468 } }, { "from" : { "x" : 347, "y" : 468 }, "to" : { "x" : 349, "y" : 506 } } ], "endShape" : { "a" : { "x" : 345, "y" : 499 }, "b" : { "x" : 349, "y" : 506 }, "c" : { "x" : 353, "y" : 499 }, "type" : "ARROW", "centre" : { "x" : 353, "y" : 499 } }, "reactionShape" : { "c" : { "x" : 347, "y" : 468 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 347, "y" : 468 } }, "inputs" : [ { "id" : 22, "points" : [ { "x" : 348, "y" : 255 } ] }, { "id" : 72, "points" : [ { "x" : 441, "y" : 550 } ] } ], "outputs" : [ { "id" : 68 } ] }, { "id" : 69, "reactomeId" : 451826, "displayName" : "YKI binds to EX", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 451, "y" : 635 }, "minX" : 287, "maxX" : 456, "minY" : 611, "maxY" : 689, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 451, "y" : 611 }, "to" : { "x" : 451, "y" : 635 } }, { "from" : { "x" : 451, "y" : 635 }, "to" : { "x" : 287, "y" : 689 } } ], "endShape" : { "a" : { "x" : 292, "y" : 683 }, "b" : { "x" : 287, "y" : 689 }, "c" : { "x" : 295, "y" : 691 }, "type" : "ARROW", "centre" : { "x" : 295, "y" : 691 } }, "reactionShape" : { "c" : { "x" : 451, "y" : 635 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 451, "y" : 635 } }, "inputs" : [ { "id" : 70, "points" : [ { "x" : 280, "y" : 612 } ] }, { "id" : 72, "points" : [ { "x" : 450, "y" : 578 } ] } ], "outputs" : [ { "id" : 71 } ] }, { "id" : 8, "reactomeId" : 451839, "displayName" : "DCO binds to FT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 318, "y" : 59 }, "minX" : 266, "maxX" : 373, "minY" : 54, "maxY" : 64, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 266, "y" : 60 }, "to" : { "x" : 318, "y" : 59 } }, { "from" : { "x" : 318, "y" : 59 }, "to" : { "x" : 373, "y" : 59 } } ], "endShape" : { "a" : { "x" : 366, "y" : 63 }, "b" : { "x" : 373, "y" : 59 }, "c" : { "x" : 366, "y" : 55 }, "type" : "ARROW", "centre" : { "x" : 366, "y" : 55 } }, "reactionShape" : { "c" : { "x" : 318, "y" : 59 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 318, "y" : 59 } }, "inputs" : [ { "id" : 6, "points" : [ { "x" : 266, "y" : 127 } ] }, { "id" : 9, "points" : [ { "x" : 309, "y" : 84 } ] } ], "outputs" : [ { "id" : 10 } ] }, { "id" : 11, "reactomeId" : 451856, "displayName" : "FT is phosphorylated by DCO", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 497, "y" : 60 }, "minX" : 476, "maxX" : 533, "minY" : 54, "maxY" : 66, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 476, "y" : 60 }, "to" : { "x" : 497, "y" : 60 } }, { "from" : { "x" : 497, "y" : 60 }, "to" : { "x" : 533, "y" : 59 } } ], "reactionShape" : { "a" : { "x" : 491, "y" : 54 }, "b" : { "x" : 503, "y" : 66 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 497, "y" : 60 } }, "inputs" : [ { "id" : 12, "points" : [ { "x" : 463, "y" : 90 } ] }, { "id" : 10, "points" : [ { "x" : 458, "y" : 60 } ] } ], "outputs" : [ { "id" : 13, "points" : [ { "x" : 548, "y" : 90 } ] }, { "id" : 14, "points" : [ { "x" : 566, "y" : 59 } ] } ], "catalysts" : [ { "id" : 10, "points" : [ { "x" : 415, "y" : 46 }, { "x" : 415, "y" : 14 }, { "x" : 495, "y" : 14 } ] } ] }, { "id" : 77, "reactomeId" : 390120, "displayName" : "Phosphorylated HPO dimer phosphorylates TH", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 830, "y" : 419 }, "minX" : 803, "maxX" : 856, "minY" : 413, "maxY" : 425, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 803, "y" : 419 }, "to" : { "x" : 830, "y" : 419 } }, { "from" : { "x" : 830, "y" : 419 }, "to" : { "x" : 856, "y" : 419 } } ], "reactionShape" : { "a" : { "x" : 824, "y" : 413 }, "b" : { "x" : 836, "y" : 425 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 830, "y" : 419 } }, "inputs" : [ { "id" : 78, "points" : [ { "x" : 753, "y" : 418 } ] }, { "id" : 79, "points" : [ { "x" : 776, "y" : 392 } ] } ], "outputs" : [ { "id" : 80, "points" : [ { "x" : 886, "y" : 418 } ] }, { "id" : 81, "points" : [ { "x" : 881, "y" : 385 } ] } ], "catalysts" : [ { "id" : 51, "points" : [ { "x" : 831, "y" : 492 } ] } ] }, { "id" : 15, "reactomeId" : 390116, "displayName" : "Phospho FT reduces D accumulation at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 731, "y" : 59 }, "minX" : 705, "maxX" : 762, "minY" : 53, "maxY" : 65, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 705, "y" : 60 }, "to" : { "x" : 731, "y" : 59 } }, { "from" : { "x" : 731, "y" : 59 }, "to" : { "x" : 762, "y" : 60 } } ], "reactionShape" : { "a" : { "x" : 725, "y" : 53 }, "b" : { "x" : 737, "y" : 65 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 731, "y" : 59 } }, "inputs" : [ { "id" : 16, "points" : [ { "x" : 853, "y" : 46 }, { "x" : 842, "y" : 17 }, { "x" : 720, "y" : 16 } ] }, { "id" : 14, "points" : [ { "x" : 681, "y" : 60 } ] } ], "outputs" : [ { "id" : 17, "points" : [ { "x" : 778, "y" : 108 } ] }, { "id" : 14, "points" : [ { "x" : 629, "y" : 81 }, { "x" : 636, "y" : 99 }, { "x" : 735, "y" : 100 } ] } ] }, { "id" : 83, "reactomeId" : 390059, "displayName" : "HPO dimer binds to RASSF", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 399, "y" : 201 }, "minX" : 377, "maxX" : 439, "minY" : 196, "maxY" : 206, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 377, "y" : 200 }, "to" : { "x" : 399, "y" : 201 } }, { "from" : { "x" : 399, "y" : 201 }, "to" : { "x" : 439, "y" : 202 } } ], "endShape" : { "a" : { "x" : 432, "y" : 206 }, "b" : { "x" : 439, "y" : 202 }, "c" : { "x" : 432, "y" : 198 }, "type" : "ARROW", "centre" : { "x" : 432, "y" : 198 } }, "reactionShape" : { "c" : { "x" : 399, "y" : 201 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 399, "y" : 201 } }, "inputs" : [ { "id" : 84, "points" : [ { "x" : 346, "y" : 195 } ] }, { "id" : 22, "points" : [ { "x" : 356, "y" : 227 } ] } ], "outputs" : [ { "id" : 85 } ] }, { "id" : 20, "reactomeId" : 390011, "displayName" : "HPO dimer binds to SAV", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 413, "y" : 279 }, "minX" : 390, "maxX" : 447, "minY" : 274, "maxY" : 284, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 390, "y" : 278 }, "to" : { "x" : 413, "y" : 279 } }, { "from" : { "x" : 413, "y" : 279 }, "to" : { "x" : 447, "y" : 280 } } ], "endShape" : { "a" : { "x" : 440, "y" : 284 }, "b" : { "x" : 447, "y" : 280 }, "c" : { "x" : 440, "y" : 276 }, "type" : "ARROW", "centre" : { "x" : 440, "y" : 276 } }, "reactionShape" : { "c" : { "x" : 413, "y" : 279 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 413, "y" : 279 } }, "inputs" : [ { "id" : 21, "points" : [ { "x" : 390, "y" : 311 } ] }, { "id" : 22, "points" : [ { "x" : 361, "y" : 255 } ] } ], "outputs" : [ { "id" : 23 } ] }, { "id" : 87, "reactomeId" : 451846, "displayName" : "LFT binds to FT and DS", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1011, "y" : 59 }, "minX" : 972, "maxX" : 1031, "minY" : 54, "maxY" : 64, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 972, "y" : 60 }, "to" : { "x" : 1011, "y" : 59 } }, { "from" : { "x" : 1011, "y" : 59 }, "to" : { "x" : 1031, "y" : 59 } } ], "endShape" : { "a" : { "x" : 1024, "y" : 63 }, "b" : { "x" : 1031, "y" : 59 }, "c" : { "x" : 1024, "y" : 55 }, "type" : "ARROW", "centre" : { "x" : 1024, "y" : 55 } }, "reactionShape" : { "c" : { "x" : 1011, "y" : 59 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1011, "y" : 59 } }, "inputs" : [ { "id" : 88, "points" : [ { "x" : 955, "y" : 104 } ], "stoichiometry" : 2 }, { "id" : 14, "points" : [ { "x" : 647, "y" : 39 }, { "x" : 703, "y" : 0 }, { "x" : 931, "y" : 0 } ] } ], "outputs" : [ { "id" : 89 } ] }, { "id" : 24, "reactomeId" : 390087, "displayName" : "WTS binds to SAV", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 599, "y" : 279 }, "minX" : 577, "maxX" : 623, "minY" : 274, "maxY" : 284, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 577, "y" : 279 }, "to" : { "x" : 599, "y" : 279 } }, { "from" : { "x" : 599, "y" : 279 }, "to" : { "x" : 623, "y" : 279 } } ], "endShape" : { "a" : { "x" : 616, "y" : 283 }, "b" : { "x" : 623, "y" : 279 }, "c" : { "x" : 616, "y" : 275 }, "type" : "ARROW", "centre" : { "x" : 616, "y" : 275 } }, "reactionShape" : { "c" : { "x" : 599, "y" : 279 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 599, "y" : 279 } }, "inputs" : [ { "id" : 25, "points" : [ { "x" : 567, "y" : 251 } ] }, { "id" : 23, "points" : [ { "x" : 530, "y" : 280 } ] } ], "outputs" : [ { "id" : 26 } ] }, { "id" : 27, "reactomeId" : 390124, "displayName" : "MATS binds to HPO dimer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 795, "y" : 279 }, "minX" : 761, "maxX" : 819, "minY" : 274, "maxY" : 284, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 761, "y" : 279 }, "to" : { "x" : 795, "y" : 279 } }, { "from" : { "x" : 795, "y" : 279 }, "to" : { "x" : 819, "y" : 279 } } ], "endShape" : { "a" : { "x" : 812, "y" : 283 }, "b" : { "x" : 819, "y" : 279 }, "c" : { "x" : 812, "y" : 275 }, "type" : "ARROW", "centre" : { "x" : 812, "y" : 275 } }, "reactionShape" : { "c" : { "x" : 795, "y" : 279 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 795, "y" : 279 } }, "inputs" : [ { "id" : 26, "points" : [ { "x" : 738, "y" : 279 } ] }, { "id" : 28, "points" : [ { "x" : 754, "y" : 247 } ] } ], "outputs" : [ { "id" : 29 } ] }, { "id" : 93, "reactomeId" : 390141, "displayName" : "D inhibits WTS", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 816, "y" : 168 }, "minX" : 789, "maxX" : 844, "minY" : 162, "maxY" : 174, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 789, "y" : 168 }, "to" : { "x" : 816, "y" : 168 } }, { "from" : { "x" : 816, "y" : 168 }, "to" : { "x" : 844, "y" : 168 } } ], "reactionShape" : { "a" : { "x" : 810, "y" : 162 }, "b" : { "x" : 822, "y" : 174 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 816, "y" : 168 } }, "inputs" : [ { "id" : 17, "points" : [ { "x" : 783, "y" : 136 } ] }, { "id" : 25, "points" : [ { "x" : 563, "y" : 223 }, { "x" : 563, "y" : 215 } ] } ], "outputs" : [ { "id" : 16, "points" : [ { "x" : 856, "y" : 74 } ] }, { "id" : 25, "points" : [ { "x" : 584, "y" : 233 }, { "x" : 843, "y" : 182 } ] } ] }, { "id" : 30, "reactomeId" : 390035, "displayName" : "HPO dimer autophosphorylates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1003, "y" : 280 }, "minX" : 964, "maxX" : 1035, "minY" : 274, "maxY" : 286, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 964, "y" : 280 }, "to" : { "x" : 1003, "y" : 280 } }, { "from" : { "x" : 1003, "y" : 280 }, "to" : { "x" : 1035, "y" : 279 } } ], "reactionShape" : { "a" : { "x" : 997, "y" : 274 }, "b" : { "x" : 1009, "y" : 286 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1003, "y" : 280 } }, "inputs" : [ { "id" : 29, "points" : [ { "x" : 944, "y" : 280 } ] }, { "id" : 31, "points" : [ { "x" : 949, "y" : 239 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 32, "points" : [ { "x" : 1079, "y" : 279 } ] }, { "id" : 33, "points" : [ { "x" : 1057, "y" : 239 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 29, "points" : [ { "x" : 880, "y" : 301 }, { "x" : 879, "y" : 320 }, { "x" : 1003, "y" : 320 } ] } ] }, { "id" : 97, "reactomeId" : 390133, "displayName" : "YKI transports from the cytosol to the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 494, "y" : 788 }, "minX" : 456, "maxX" : 500, "minY" : 578, "maxY" : 823, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 456, "y" : 578 }, "to" : { "x" : 491, "y" : 631 } }, { "from" : { "x" : 491, "y" : 631 }, "to" : { "x" : 494, "y" : 788 } }, { "from" : { "x" : 494, "y" : 788 }, "to" : { "x" : 494, "y" : 823 } } ], "endShape" : { "a" : { "x" : 490, "y" : 816 }, "b" : { "x" : 494, "y" : 823 }, "c" : { "x" : 498, "y" : 816 }, "type" : "ARROW", "centre" : { "x" : 498, "y" : 816 } }, "reactionShape" : { "a" : { "x" : 488, "y" : 782 }, "b" : { "x" : 500, "y" : 794 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 494, "y" : 788 } }, "inputs" : [ { "id" : 72 } ], "outputs" : [ { "id" : 98 } ] }, { "id" : 34, "reactomeId" : 390145, "displayName" : "Phosphorylated HPO dimer phosphorylates SAV", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1263, "y" : 282 }, "minX" : 1222, "maxX" : 1304, "minY" : 276, "maxY" : 288, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1222, "y" : 282 }, "to" : { "x" : 1263, "y" : 282 } }, { "from" : { "x" : 1263, "y" : 282 }, "to" : { "x" : 1304, "y" : 282 } } ], "reactionShape" : { "a" : { "x" : 1257, "y" : 276 }, "b" : { "x" : 1269, "y" : 288 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1263, "y" : 282 } }, "inputs" : [ { "id" : 32, "points" : [ { "x" : 1194, "y" : 281 } ] }, { "id" : 35, "points" : [ { "x" : 1208, "y" : 239 } ] } ], "outputs" : [ { "id" : 37, "points" : [ { "x" : 1322, "y" : 241 } ] }, { "id" : 36, "points" : [ { "x" : 1342, "y" : 282 } ] } ], "catalysts" : [ { "id" : 32, "points" : [ { "x" : 1136, "y" : 308 }, { "x" : 1136, "y" : 330 }, { "x" : 1260, "y" : 328 } ] } ] }, { "id" : 99, "reactomeId" : 390184, "displayName" : "YKI binds to SD and activates transcription", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 541, "y" : 986 }, "minX" : 516, "maxX" : 576, "minY" : 981, "maxY" : 991, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 516, "y" : 987 }, "to" : { "x" : 541, "y" : 986 } }, { "from" : { "x" : 541, "y" : 986 }, "to" : { "x" : 576, "y" : 986 } } ], "endShape" : { "a" : { "x" : 569, "y" : 990 }, "b" : { "x" : 576, "y" : 986 }, "c" : { "x" : 569, "y" : 982 }, "type" : "ARROW", "centre" : { "x" : 569, "y" : 982 } }, "reactionShape" : { "c" : { "x" : 541, "y" : 986 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 541, "y" : 986 } }, "inputs" : [ { "id" : 100, "points" : [ { "x" : 491, "y" : 987 } ] }, { "id" : 98, "points" : [ { "x" : 496, "y" : 851 } ] } ], "outputs" : [ { "id" : 101 } ] }, { "id" : 38, "reactomeId" : 390112, "displayName" : "Phosphorylated HPO dimer phosphorylates WTS", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1504, "y" : 327 }, "minX" : 1498, "maxX" : 1510, "minY" : 280, "maxY" : 358, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1502, "y" : 280 }, "to" : { "x" : 1504, "y" : 327 } }, { "from" : { "x" : 1504, "y" : 327 }, "to" : { "x" : 1503, "y" : 358 } } ], "reactionShape" : { "a" : { "x" : 1498, "y" : 321 }, "b" : { "x" : 1510, "y" : 333 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1504, "y" : 327 } }, "inputs" : [ { "id" : 36, "points" : [ { "x" : 1467, "y" : 281 } ] }, { "id" : 39, "points" : [ { "x" : 1480, "y" : 244 } ] } ], "outputs" : [ { "id" : 40, "points" : [ { "x" : 1523, "y" : 431 } ] }, { "id" : 41, "points" : [ { "x" : 1426, "y" : 490 } ] } ], "catalysts" : [ { "id" : 36, "points" : [ { "x" : 1402, "y" : 311 }, { "x" : 1402, "y" : 328 } ] } ] }, { "id" : 102, "reactomeId" : 451819, "displayName" : "YKI binds to HTH and TSH and activates transcription", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 617, "y" : 874 }, "minX" : 582, "maxX" : 658, "minY" : 869, "maxY" : 879, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 582, "y" : 873 }, "to" : { "x" : 617, "y" : 874 } }, { "from" : { "x" : 617, "y" : 874 }, "to" : { "x" : 658, "y" : 874 } } ], "endShape" : { "a" : { "x" : 651, "y" : 878 }, "b" : { "x" : 658, "y" : 874 }, "c" : { "x" : 651, "y" : 870 }, "type" : "ARROW", "centre" : { "x" : 651, "y" : 870 } }, "reactionShape" : { "c" : { "x" : 617, "y" : 874 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 617, "y" : 874 } }, "inputs" : [ { "id" : 98, "points" : [ { "x" : 511, "y" : 846 }, { "x" : 548, "y" : 874 } ] }, { "id" : 103, "points" : [ { "x" : 567, "y" : 893 } ] }, { "id" : 104, "points" : [ { "x" : 566, "y" : 850 } ] } ], "outputs" : [ { "id" : 105 } ] }, { "id" : 44, "reactomeId" : 390154, "displayName" : "MATS is phosphorylated by HPO dimer and binds to phosphorylated WTS", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1278, "y" : 527 }, "minX" : 1240, "maxX" : 1313, "minY" : 521, "maxY" : 533, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1313, "y" : 527 }, "to" : { "x" : 1278, "y" : 527 } }, { "from" : { "x" : 1278, "y" : 527 }, "to" : { "x" : 1240, "y" : 528 } } ], "reactionShape" : { "a" : { "x" : 1272, "y" : 521 }, "b" : { "x" : 1284, "y" : 533 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1278, "y" : 527 } }, "inputs" : [ { "id" : 41, "points" : [ { "x" : 1353, "y" : 526 } ] }, { "id" : 45, "points" : [ { "x" : 1346, "y" : 483 } ] } ], "outputs" : [ { "id" : 46, "points" : [ { "x" : 1196, "y" : 529 } ] }, { "id" : 47, "points" : [ { "x" : 1221, "y" : 483 } ] } ], "catalysts" : [ { "id" : 41, "points" : [ { "x" : 1409, "y" : 560 }, { "x" : 1410, "y" : 578 }, { "x" : 1278, "y" : 578 } ] } ] }, { "id" : 48, "reactomeId" : 390025, "displayName" : "Phosphorylated WTS autophosphorylates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 999, "y" : 533 }, "minX" : 957, "maxX" : 1033, "minY" : 527, "maxY" : 539, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1033, "y" : 533 }, "to" : { "x" : 999, "y" : 533 } }, { "from" : { "x" : 999, "y" : 533 }, "to" : { "x" : 957, "y" : 533 } } ], "reactionShape" : { "a" : { "x" : 993, "y" : 527 }, "b" : { "x" : 1005, "y" : 539 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 999, "y" : 533 } }, "inputs" : [ { "id" : 46, "points" : [ { "x" : 1066, "y" : 532 } ] }, { "id" : 49, "points" : [ { "x" : 1058, "y" : 483 } ] } ], "outputs" : [ { "id" : 50, "points" : [ { "x" : 940, "y" : 495 } ] }, { "id" : 51, "points" : [ { "x" : 891, "y" : 533 } ] } ], "catalysts" : [ { "id" : 46, "points" : [ { "x" : 1128, "y" : 566 }, { "x" : 1126, "y" : 589 }, { "x" : 999, "y" : 590 } ] } ] }, { "id" : 54, "reactomeId" : 390061, "displayName" : "YKI binds to phosphorylated WTS", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 693, "y" : 586 }, "minX" : 688, "maxX" : 710, "minY" : 557, "maxY" : 672, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 693, "y" : 557 }, "to" : { "x" : 693, "y" : 586 } }, { "from" : { "x" : 693, "y" : 586 }, "to" : { "x" : 693, "y" : 631 } }, { "from" : { "x" : 693, "y" : 631 }, "to" : { "x" : 710, "y" : 672 } } ], "endShape" : { "a" : { "x" : 704, "y" : 667 }, "b" : { "x" : 710, "y" : 672 }, "c" : { "x" : 711, "y" : 664 }, "type" : "ARROW", "centre" : { "x" : 711, "y" : 664 } }, "reactionShape" : { "c" : { "x" : 693, "y" : 586 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 693, "y" : 586 } }, "inputs" : [ { "id" : 51, "points" : [ { "x" : 774, "y" : 543 } ] }, { "id" : 72, "points" : [ { "x" : 466, "y" : 563 } ] } ], "outputs" : [ { "id" : 56 } ] }, { "id" : 58, "reactomeId" : 390044, "displayName" : "YKI is phosphorylated by and then dissociates from phosphorylated WTS", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 829, "y" : 639 }, "minX" : 823, "maxX" : 835, "minY" : 598, "maxY" : 681, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 830, "y" : 681 }, "to" : { "x" : 829, "y" : 639 } }, { "from" : { "x" : 829, "y" : 639 }, "to" : { "x" : 829, "y" : 598 } } ], "reactionShape" : { "a" : { "x" : 823, "y" : 633 }, "b" : { "x" : 835, "y" : 645 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 829, "y" : 639 } }, "inputs" : [ { "id" : 56, "points" : [ { "x" : 785, "y" : 696 } ] }, { "id" : 59, "points" : [ { "x" : 862, "y" : 712 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 60, "points" : [ { "x" : 891, "y" : 600 } ], "stoichiometry" : 3 }, { "id" : 51, "points" : [ { "x" : 830, "y" : 576 } ] }, { "id" : 61, "points" : [ { "x" : 953, "y" : 659 } ] } ], "catalysts" : [ { "id" : 56, "points" : [ { "x" : 726, "y" : 672 }, { "x" : 726, "y" : 639 } ] } ] }, { "id" : 62, "reactomeId" : 390078, "displayName" : "14-3-3 dimer binds to phosphorylated YKI", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 975, "y" : 756 }, "minX" : 970, "maxX" : 980, "minY" : 729, "maxY" : 795, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 975, "y" : 729 }, "to" : { "x" : 975, "y" : 756 } }, { "from" : { "x" : 975, "y" : 756 }, "to" : { "x" : 975, "y" : 795 } } ], "endShape" : { "a" : { "x" : 971, "y" : 788 }, "b" : { "x" : 975, "y" : 795 }, "c" : { "x" : 979, "y" : 788 }, "type" : "ARROW", "centre" : { "x" : 979, "y" : 788 } }, "reactionShape" : { "c" : { "x" : 975, "y" : 756 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 975, "y" : 756 } }, "inputs" : [ { "id" : 63, "points" : [ { "x" : 1013, "y" : 718 } ] }, { "id" : 61, "points" : [ { "x" : 975, "y" : 687 } ] } ], "outputs" : [ { "id" : 64 } ] } ], "compartments" : [ { "id" : 1, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 934, "y" : 587 }, "minX" : 264, "maxX" : 1604, "minY" : 54, "maxY" : 1121, "prop" : { "x" : 264, "y" : 54, "width" : 1340, "height" : 1067 }, "textPosition" : { "x" : 298, "y" : 1074 }, "insets" : { "x" : 273, "y" : 64, "width" : 1316, "height" : 1046 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 3, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 17, 16, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 41, 44, 45, 46, 47, 48, 49, 50, 51, 54, 56, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 77, 78, 79, 80, 81, 83, 84, 85, 87, 88, 89, 2, 93, 40 ] }, { "id" : 2, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 608, "y" : 917 }, "minX" : 369, "maxX" : 847, "minY" : 780, "maxY" : 1054, "prop" : { "x" : 369, "y" : 780, "width" : 478, "height" : 274 }, "textPosition" : { "x" : 383, "y" : 998 }, "insets" : { "x" : 380, "y" : 791, "width" : 456, "height" : 253 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 98, 97, 99, 100, 102, 103, 104, 105, 101 ] }, { "id" : 92, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 93, "y" : 337 }, "minX" : 0, "maxX" : 187, "minY" : 216, "maxY" : 459, "prop" : { "x" : 0, "y" : 216, "width" : 187, "height" : 243 }, "textPosition" : { "x" : 16, "y" : 408 }, "insets" : { "x" : 10, "y" : 226, "width" : 166, "height" : 224 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 4 ] } ], "notes" : [ ], "links" : [ ], "shadows" : [ { "id" : 106, "reactomeId" : 390150, "displayName" : "DS ligand bound to FT receptor", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 860, "y" : 438 }, "minX" : 163, "maxX" : 1558, "minY" : 32, "maxY" : 844, "prop" : { "x" : 878, "y" : 39, "width" : 680, "height" : 805 }, "points" : [ { "x" : 163, "y" : 32 }, { "x" : 1558, "y" : 32 }, { "x" : 1558, "y" : 844 }, { "x" : 163, "y" : 844 } ], "colour" : "#4684ee" }, { "id" : 107, "reactomeId" : 390178, "displayName" : "DS ligand not bound to FT receptor", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 652, "y" : 524 }, "minX" : 427, "maxX" : 878, "minY" : 39, "maxY" : 1009, "prop" : { "x" : 427, "y" : 844, "width" : 451, "height" : 165 }, "points" : [ { "x" : 427, "y" : 39 }, { "x" : 878, "y" : 39 }, { "x" : 878, "y" : 1009 }, { "x" : 427, "y" : 1009 } ], "colour" : "#dc3912" } ], "minX" : 0, "maxX" : 1604, "minY" : 0, "maxY" : 1121, "disease" : false }