{
  "dbId" : 11049644,
  "stId" : "R-DDI-450282",
  "speciesName" : "Dictyostelium discoideum",
  "nodes" : [ {
    "dbId" : 11006119,
    "stId" : "R-DDI-112359",
    "displayName" : "phospho-p-T202,Y204-MAPK3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q55C57",
    "standardIdentifier" : "uniprot:Q55C57",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006121 ],
    "children" : [ ]
  }, {
    "dbId" : 11006117,
    "stId" : "R-DDI-109856",
    "displayName" : "p-Y185,Y187 MAPK1 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 170941,
    "parents" : [ 11006125, 11006130 ],
    "children" : [ 11006115 ]
  }, {
    "dbId" : 11006115,
    "stId" : "R-DDI-112354",
    "displayName" : "phospho-p-T185,Y187-MAPK1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q55C57",
    "standardIdentifier" : "uniprot:Q55C57",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006117 ],
    "children" : [ ]
  }, {
    "dbId" : 11006883,
    "stId" : "R-DDI-203794",
    "displayName" : "DUSP4 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q55BI8",
    "standardIdentifier" : "uniprot:Q55BI8",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006904 ],
    "children" : [ ]
  }, {
    "dbId" : 11006113,
    "stId" : "R-DDI-199849",
    "displayName" : "Phospho-Ribosomal protein S6 kinase [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 170941,
    "diagramIds" : [ 148574 ],
    "parents" : [ ],
    "children" : [ 11006111, 11006096, 11006103 ]
  }, {
    "dbId" : 11006125,
    "stId" : "R-DDI-199878",
    "displayName" : "p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 170941,
    "diagramIds" : [ 148576 ],
    "parents" : [ ],
    "children" : [ 11006121, 11006123, 11006117 ]
  }, {
    "dbId" : 11006893,
    "stId" : "R-DDI-203791-2",
    "displayName" : "DUSP7 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54N84",
    "standardIdentifier" : "uniprot:Q54N84",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006900 ],
    "children" : [ ]
  }, {
    "dbId" : 11006123,
    "stId" : "R-DDI-9610768",
    "displayName" : "p-T1218, Y220 MAPK7 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 170941,
    "parents" : [ 11006125 ],
    "children" : [ 11006078 ]
  }, {
    "dbId" : 11006121,
    "stId" : "R-DDI-109845",
    "displayName" : "p-T202, Y204 MAPK3 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 170941,
    "parents" : [ 11006125, 11006130 ],
    "children" : [ 11006119 ]
  }, {
    "dbId" : 113550,
    "stId" : "R-ALL-113550",
    "displayName" : "Pi [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 148580 ],
    "identifier" : "43474",
    "standardIdentifier" : "chebi:43474",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 11006888,
    "stId" : "R-DDI-203791",
    "displayName" : "DUSP7 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54CK7",
    "standardIdentifier" : "uniprot:Q54CK7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006900 ],
    "children" : [ ]
  }, {
    "dbId" : 11006263,
    "stId" : "R-DDI-5675356",
    "displayName" : "MAPK1 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 170941,
    "parents" : [ 11006273 ],
    "children" : [ 11006261 ]
  }, {
    "dbId" : 11006902,
    "stId" : "R-DDI-2871619",
    "displayName" : "DUSP6 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54CK7",
    "standardIdentifier" : "uniprot:Q54CK7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006904 ],
    "children" : [ ]
  }, {
    "dbId" : 11006261,
    "stId" : "R-DDI-199960",
    "displayName" : "MAPK1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q55C57",
    "standardIdentifier" : "uniprot:Q55C57",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006263 ],
    "children" : [ ]
  }, {
    "dbId" : 11006900,
    "stId" : "R-DDI-203791-4",
    "displayName" : "Homologues of DUSP7 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 170941,
    "parents" : [ 11006904 ],
    "children" : [ 11006888, 11006893, 11006898 ]
  }, {
    "dbId" : 11006130,
    "stId" : "R-DDI-198701",
    "displayName" : "p-T,Y MAPK dimers [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 170941,
    "diagramIds" : [ 148566 ],
    "parents" : [ ],
    "children" : [ 11006121, 11006117 ]
  }, {
    "dbId" : 11006898,
    "stId" : "R-DDI-203791-3",
    "displayName" : "DUSP7 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q556Y8",
    "standardIdentifier" : "uniprot:Q556Y8",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006900 ],
    "children" : [ ]
  }, {
    "dbId" : 11006271,
    "stId" : "R-DDI-9610770",
    "displayName" : "MAPK7 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 170941,
    "parents" : [ 11006273 ],
    "children" : [ 11006269 ]
  }, {
    "dbId" : 11006269,
    "stId" : "R-DDI-199961",
    "displayName" : "MAPK7 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "P42525",
    "standardIdentifier" : "uniprot:P42525",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006271 ],
    "children" : [ ]
  }, {
    "dbId" : 11006267,
    "stId" : "R-DDI-5675359",
    "displayName" : "MAPK3 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 170941,
    "parents" : [ 11006273 ],
    "children" : [ 11006265 ]
  }, {
    "dbId" : 11006265,
    "stId" : "R-DDI-73724",
    "displayName" : "MAPK3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q55C57",
    "standardIdentifier" : "uniprot:Q55C57",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006267 ],
    "children" : [ ]
  }, {
    "dbId" : 11006904,
    "stId" : "R-DDI-203792",
    "displayName" : "ERK-specific DUSP [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 170941,
    "diagramIds" : [ 148583 ],
    "parents" : [ ],
    "children" : [ 11006883, 11006900, 11006902 ]
  }, {
    "dbId" : 11006086,
    "stId" : "R-DDI-199869",
    "displayName" : "RPS6KA3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q8MYF1",
    "standardIdentifier" : "uniprot:Q8MYF1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006088 ],
    "children" : [ ]
  }, {
    "dbId" : 11006084,
    "stId" : "R-DDI-199861",
    "displayName" : "RPS6KA2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q8MYF1",
    "standardIdentifier" : "uniprot:Q8MYF1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006088 ],
    "children" : [ ]
  }, {
    "dbId" : 11006082,
    "stId" : "R-DDI-199860",
    "displayName" : "RPS6KA1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q8MYF1",
    "standardIdentifier" : "uniprot:Q8MYF1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006088 ],
    "children" : [ ]
  }, {
    "dbId" : 29358,
    "stId" : "R-ALL-29358",
    "displayName" : "ATP [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 148563, 148568, 148572 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113582,
    "stId" : "R-ALL-113582",
    "displayName" : "ADP [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 148565, 148569, 148575 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 11006088,
    "stId" : "R-DDI-199858",
    "displayName" : "Ribosomal protein S6 kinase [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 170941,
    "diagramIds" : [ 148573 ],
    "parents" : [ ],
    "children" : [ 11006082, 11006084, 11006086 ]
  }, {
    "dbId" : 11006103,
    "stId" : "R-DDI-199871",
    "displayName" : "phospho-p-4S,T356,T570-RPS6KA2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q8MYF1",
    "standardIdentifier" : "uniprot:Q8MYF1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006113 ],
    "children" : [ ]
  }, {
    "dbId" : 11006096,
    "stId" : "R-DDI-199829",
    "displayName" : "phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q8MYF1",
    "standardIdentifier" : "uniprot:Q8MYF1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006113 ],
    "children" : [ ]
  }, {
    "dbId" : 11006111,
    "stId" : "R-DDI-199830",
    "displayName" : "phospho-p-4S,T231,T365-RPS6KA3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q8MYF1",
    "standardIdentifier" : "uniprot:Q8MYF1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006113 ],
    "children" : [ ]
  }, {
    "dbId" : 11006049,
    "stId" : "R-DDI-198741-2",
    "displayName" : "phospho-p-T180,Y182-MAPK11 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54V35",
    "standardIdentifier" : "uniprot:Q54V35",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006058 ],
    "children" : [ ]
  }, {
    "dbId" : 11002720,
    "stId" : "R-DDI-165997",
    "displayName" : "PP2A-subunit A [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 170941,
    "parents" : [ 11006280 ],
    "children" : [ 11002716 ]
  }, {
    "dbId" : 11006062,
    "stId" : "R-DDI-446227-2",
    "displayName" : "phospho-p-T180,Y182-MAPK14 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54V83",
    "standardIdentifier" : "uniprot:Q54V83",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006064 ],
    "children" : [ ]
  }, {
    "dbId" : 11006060,
    "stId" : "R-DDI-446227",
    "displayName" : "phospho-p-T180,Y182-MAPK14 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54V35",
    "standardIdentifier" : "uniprot:Q54V35",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006064 ],
    "children" : [ ]
  }, {
    "dbId" : 11006058,
    "stId" : "R-DDI-198741-4",
    "displayName" : "Homologues of p-T180,Y182-MAPK11 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 170941,
    "parents" : [ 11006066 ],
    "children" : [ 11006056, 11006042, 11006049 ]
  }, {
    "dbId" : 11006056,
    "stId" : "R-DDI-198741-3",
    "displayName" : "phospho-p-T180,Y182-MAPK11 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54V83",
    "standardIdentifier" : "uniprot:Q54V83",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006058 ],
    "children" : [ ]
  }, {
    "dbId" : 11006066,
    "stId" : "R-DDI-198703",
    "displayName" : "p-p38 MAPK alpha/beta [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 170941,
    "diagramIds" : [ 148570 ],
    "parents" : [ ],
    "children" : [ 11006058, 11006064 ]
  }, {
    "dbId" : 11006064,
    "stId" : "R-DDI-446227-3",
    "displayName" : "Homologues of p-T180,Y182-MAPK14 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 170941,
    "parents" : [ 11006066 ],
    "children" : [ 11006060, 11006062 ]
  }, {
    "dbId" : 11006078,
    "stId" : "R-DDI-198738",
    "displayName" : "phospho-p-T218,Y221-MAPK7 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "diagramIds" : [ 148585 ],
    "identifier" : "P42525",
    "standardIdentifier" : "uniprot:P42525",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006123 ],
    "children" : [ ]
  }, {
    "dbId" : 11006278,
    "stId" : "R-DDI-3008956",
    "displayName" : "psrA [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54VB6",
    "standardIdentifier" : "uniprot:Q54VB6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "psrA" ],
    "parents" : [ 11006280 ],
    "children" : [ ]
  }, {
    "dbId" : 11006273,
    "stId" : "R-DDI-199955",
    "displayName" : "MAPK3/MAPK1/MAPK7 dimers [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 170941,
    "diagramIds" : [ 148579 ],
    "parents" : [ ],
    "children" : [ 11006267, 11006271, 11006263 ]
  }, {
    "dbId" : 11006029,
    "stId" : "R-DDI-198657",
    "displayName" : "RPS6KA5 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "diagramIds" : [ 148562 ],
    "identifier" : "Q8MYF1",
    "standardIdentifier" : "uniprot:Q8MYF1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 11006280,
    "stId" : "R-DDI-165970",
    "displayName" : "PP2A-ABdeltaC complex [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 170941,
    "diagramIds" : [ 148581 ],
    "parents" : [ ],
    "children" : [ 11002720, 11006278, 11002711 ]
  }, {
    "dbId" : 113518,
    "stId" : "R-ALL-113518",
    "displayName" : "H2O [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 148578 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 11002711,
    "stId" : "R-DDI-165974",
    "displayName" : "PP2A-catalytic subunit C [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 170941,
    "parents" : [ 11006280 ],
    "children" : [ 11002709 ]
  }, {
    "dbId" : 11002709,
    "stId" : "R-DDI-165978",
    "displayName" : "PPP2CA [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q9XZE5",
    "standardIdentifier" : "uniprot:Q9XZE5",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11002711 ],
    "children" : [ ]
  }, {
    "dbId" : 11006035,
    "stId" : "R-DDI-198683",
    "displayName" : "phospho-p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "diagramIds" : [ 148564 ],
    "identifier" : "Q8MYF1",
    "standardIdentifier" : "uniprot:Q8MYF1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 11002716,
    "stId" : "R-DDI-165968",
    "displayName" : "pppA [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54QR9",
    "standardIdentifier" : "uniprot:Q54QR9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "pppA" ],
    "parents" : [ 11002720 ],
    "children" : [ ]
  }, {
    "dbId" : 11006042,
    "stId" : "R-DDI-198741",
    "displayName" : "phospho-p-T180,Y182-MAPK11 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54US6",
    "standardIdentifier" : "uniprot:Q54US6",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11006058 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 11006133,
    "stId" : "R-DDI-198756",
    "displayName" : "ERK1/2 phosphorylates MSK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 29358, 11006029 ],
    "outputs" : [ 113582, 11006035 ],
    "catalysts" : [ 11006130 ],
    "efs" : [ ],
    "diagramIds" : [ 148561 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 11006069,
    "stId" : "R-DDI-198669",
    "displayName" : "p38MAPK phosphorylates MSK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 29358, 11006029 ],
    "outputs" : [ 113582, 11006035 ],
    "catalysts" : [ 11006066 ],
    "efs" : [ ],
    "diagramIds" : [ 148567 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 11006128,
    "stId" : "R-DDI-198746",
    "displayName" : "ERK1/2/5 activate RSK1/2/3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 11006088, 29358 ],
    "outputs" : [ 113582, 11006113 ],
    "catalysts" : [ 11006125 ],
    "efs" : [ ],
    "diagramIds" : [ 148571 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 11006283,
    "stId" : "R-DDI-199959",
    "displayName" : "ERKs are inactivated by protein phosphatase 2A",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 113518, 11006125 ],
    "outputs" : [ 113550, 11006273 ],
    "catalysts" : [ 11006280 ],
    "efs" : [ ],
    "diagramIds" : [ 148577 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 11006907,
    "stId" : "R-DDI-203797",
    "displayName" : "ERKs are inactivated by dual-specific phosphatases (DUSPs)",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 113518, 11006125 ],
    "outputs" : [ 113550, 11006273 ],
    "catalysts" : [ 11006904 ],
    "efs" : [ ],
    "diagramIds" : [ 148582 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 11049706,
    "stId" : "R-DDI-202670",
    "displayName" : "ERKs are inactivated",
    "events" : [ 11006283, 11006907 ]
  }, {
    "dbId" : 11049642,
    "stId" : "R-DDI-198753",
    "displayName" : "ERK/MAPK targets",
    "events" : [ 11006133, 11006069, 11006283, 11006907, 11006128, 11006283 ]
  } ]
}