{ "dbId" : 10331985, "stableId" : "R-CFA-9864848", "displayName" : "Complex IV assembly", "nodes" : [ { "id" : 51781, "reactomeId" : 10237156, "displayName" : "Cytochrome c oxidase", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2003, "y" : 250 }, "minX" : 1960, "maxX" : 2053, "minY" : 187, "maxY" : 308, "prop" : { "x" : 1960, "y" : 193, "width" : 87, "height" : 115 }, "textPosition" : { "x" : 1960, "y" : 273 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2047, "y" : 193 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2047, "y" : 193 } } }, "connectors" : [ ] }, { "id" : 51783, "reactomeId" : 10328637, "displayName" : "TP53 Regulates Metabolic Genes", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 571, "y" : 430 }, "minX" : 509, "maxX" : 634, "minY" : 405, "maxY" : 455, "prop" : { "x" : 509, "y" : 405, "width" : 125, "height" : 50 }, "textPosition" : { "x" : 511, "y" : 408 }, "connectors" : [ ] }, { "id" : 51784, "reactomeId" : 10328657, "displayName" : "Respiratory electron transport", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2290, "y" : 213 }, "minX" : 2220, "maxX" : 2360, "minY" : 184, "maxY" : 243, "prop" : { "x" : 2220, "y" : 184, "width" : 140, "height" : 59 }, "textPosition" : { "x" : 2224, "y" : 192 }, "connectors" : [ ] }, { "id" : 51752, "reactomeId" : 10326058, "displayName" : "TIMM21:COX4:COX5A:COX6C", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 123, "y" : 489 }, "minX" : 92, "maxX" : 308, "minY" : 450, "maxY" : 523, "prop" : { "x" : 92, "y" : 456, "width" : 63, "height" : 67 }, "textPosition" : { "x" : 94, "y" : 460 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 155, "y" : 456 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 155, "y" : 456 } } }, "connectors" : [ { "edgeId" : 51751, "type" : "INPUT", "segments" : [ { "from" : { "x" : 158, "y" : 483 }, "to" : { "x" : 308, "y" : 459 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 51753, "reactomeId" : 10326062, "displayName" : "MT-CO1:Mg2+:PE:CL:MITRAC", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 309, "y" : 524 }, "minX" : 254, "maxX" : 370, "minY" : 459, "maxY" : 543, "prop" : { "x" : 254, "y" : 506, "width" : 110, "height" : 37 }, "textPosition" : { "x" : 260, "y" : 508 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 364, "y" : 506 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 364, "y" : 506 } } }, "connectors" : [ { "edgeId" : 51751, "type" : "INPUT", "segments" : [ { "from" : { "x" : 308, "y" : 503 }, "to" : { "x" : 308, "y" : 459 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 51785, "reactomeId" : 10331147, "displayName" : "Mitochondrial translation", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 686, "y" : 607 }, "minX" : 637, "maxX" : 735, "minY" : 583, "maxY" : 631, "prop" : { "x" : 637, "y" : 583, "width" : 98, "height" : 48 }, "textPosition" : { "x" : 637, "y" : 585 }, "connectors" : [ ] }, { "id" : 51754, "reactomeId" : 10326066, "displayName" : "MT-CO1:Mg2+:PE:CL:MITRAC:TIMM21:COX4:COX5A:COX6C", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 308, "y" : 386 }, "minX" : 238, "maxX" : 384, "minY" : 221, "maxY" : 415, "prop" : { "x" : 238, "y" : 358, "width" : 140, "height" : 57 }, "textPosition" : { "x" : 240, "y" : 366 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 378, "y" : 358 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 378, "y" : 358 } } }, "connectors" : [ { "edgeId" : 51751, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 51755, "type" : "INPUT", "segments" : [ { "from" : { "x" : 308, "y" : 355 }, "to" : { "x" : 310, "y" : 221 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 51786, "reactomeId" : 10329641, "displayName" : "Metabolism of porphyrins", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1433, "y" : 437 }, "minX" : 1384, "maxX" : 1483, "minY" : 415, "maxY" : 460, "prop" : { "x" : 1384, "y" : 415, "width" : 99, "height" : 45 }, "textPosition" : { "x" : 1384, "y" : 416 }, "connectors" : [ ] }, { "id" : 51787, "reactomeId" : 10330867, "displayName" : "Mitochondrial protein import", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 55, "y" : 394 }, "minX" : 0, "maxX" : 110, "minY" : 365, "maxY" : 423, "prop" : { "x" : 0, "y" : 365, "width" : 110, "height" : 58 }, "textPosition" : { "x" : 2, "y" : 372 }, "connectors" : [ ] }, { "id" : 51756, "reactomeId" : 10326074, "displayName" : "COX17:Cu", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 268, "y" : 147 }, "minX" : 243, "maxX" : 310, "minY" : 123, "maxY" : 221, "prop" : { "x" : 243, "y" : 129, "width" : 51, "height" : 36 }, "textPosition" : { "x" : 244, "y" : 130 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 294, "y" : 129 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 294, "y" : 129 } } }, "connectors" : [ { "edgeId" : 51755, "type" : "INPUT", "segments" : [ { "from" : { "x" : 278, "y" : 168 }, "to" : { "x" : 310, "y" : 221 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 51757, "reactomeId" : 10326078, "displayName" : "MT-CO1:Cu2+:Mg2+:PE:CL:MITRAC:TIMM21:COX4:COX5A:COX6C", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 619, "y" : 253 }, "minX" : 495, "maxX" : 663, "minY" : 188, "maxY" : 312, "prop" : { "x" : 582, "y" : 194, "width" : 75, "height" : 118 }, "textPosition" : { "x" : 582, "y" : 193 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 657, "y" : 194 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 657, "y" : 194 } } }, "connectors" : [ { "edgeId" : 51755, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 579, "y" : 253 }, "to" : { "x" : 495, "y" : 253 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 572, "y" : 257 }, "b" : { "x" : 579, "y" : 253 }, "c" : { "x" : 572, "y" : 249 }, "type" : "ARROW", "centre" : { "x" : 572, "y" : 249 } } } ] }, { "id" : 51758, "reactomeId" : 10326072, "displayName" : "COX17", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 569, "y" : 89 }, "minX" : 495, "maxX" : 603, "minY" : 71, "maxY" : 253, "prop" : { "x" : 541, "y" : 77, "width" : 56, "height" : 24 }, "textPosition" : { "x" : 545, "y" : 78 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 597, "y" : 77 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 597, "y" : 77 } } }, "connectors" : [ { "edgeId" : 51755, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 563, "y" : 104 }, "to" : { "x" : 495, "y" : 253 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 564, "y" : 112 }, "b" : { "x" : 563, "y" : 104 }, "c" : { "x" : 556, "y" : 109 }, "type" : "ARROW", "centre" : { "x" : 556, "y" : 109 } } } ] }, { "id" : 51759, "reactomeId" : 10326104, "displayName" : "metallochaperone complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 409, "y" : 250 }, "minX" : 365, "maxX" : 485, "minY" : 178, "maxY" : 317, "prop" : { "x" : 365, "y" : 184, "width" : 89, "height" : 133 }, "textPosition" : { "x" : 367, "y" : 268 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 454, "y" : 184 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 454, "y" : 184 } } }, "connectors" : [ { "edgeId" : 51755, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 457, "y" : 252 }, "to" : { "x" : 477, "y" : 254 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 481, "y" : 254 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 481, "y" : 254 } } } ] }, { "id" : 51764, "reactomeId" : 9864492, "displayName" : "heme A", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1432, "y" : 296 }, "minX" : 1410, "maxX" : 1456, "minY" : 280, "maxY" : 312, "prop" : { "x" : 1410, "y" : 281, "width" : 45, "height" : 31 }, "textPosition" : { "x" : 1409, "y" : 279 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1450, "y" : 286 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1450, "y" : 286 } } }, "connectors" : [ ] } ], "edges" : [ { "id" : 51751, "reactomeId" : 10326068, "displayName" : "TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 308, "y" : 460 }, "minX" : 302, "maxX" : 314, "minY" : 418, "maxY" : 466, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 308, "y" : 459 }, "to" : { "x" : 308, "y" : 460 } }, { "from" : { "x" : 308, "y" : 460 }, "to" : { "x" : 308, "y" : 418 } } ], "endShape" : { "a" : { "x" : 312, "y" : 425 }, "b" : { "x" : 308, "y" : 418 }, "c" : { "x" : 304, "y" : 425 }, "type" : "ARROW", "centre" : { "x" : 304, "y" : 425 } }, "reactionShape" : { "c" : { "x" : 308, "y" : 460 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 308, "y" : 460 } }, "inputs" : [ { "id" : 51752, "points" : [ { "x" : 158, "y" : 483 } ] }, { "id" : 51753, "points" : [ { "x" : 308, "y" : 503 } ] } ], "outputs" : [ { "id" : 51754 } ] }, { "id" : 51755, "reactomeId" : 10326107, "displayName" : "Metallochaperone inserts Cu2+ into MT-CO1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 493, "y" : 255 }, "minX" : 310, "maxX" : 499, "minY" : 166, "maxY" : 261, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 310, "y" : 221 }, "to" : { "x" : 359, "y" : 166 } }, { "from" : { "x" : 359, "y" : 166 }, "to" : { "x" : 466, "y" : 166 } }, { "from" : { "x" : 466, "y" : 166 }, "to" : { "x" : 493, "y" : 255 } }, { "from" : { "x" : 493, "y" : 255 }, "to" : { "x" : 495, "y" : 253 } } ], "reactionShape" : { "a" : { "x" : 487, "y" : 249 }, "b" : { "x" : 499, "y" : 261 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 493, "y" : 255 } }, "inputs" : [ { "id" : 51756, "points" : [ { "x" : 278, "y" : 168 } ] }, { "id" : 51754, "points" : [ { "x" : 308, "y" : 355 } ] } ], "outputs" : [ { "id" : 51757, "points" : [ { "x" : 579, "y" : 253 } ] }, { "id" : 51758, "points" : [ { "x" : 563, "y" : 104 } ] } ], "catalysts" : [ { "id" : 51759, "points" : [ { "x" : 457, "y" : 252 } ] } ] } ], "compartments" : [ { "id" : 51760, "reactomeId" : 17927, "displayName" : "mitochondrial intermembrane space", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1255, "y" : 535 }, "minX" : 33, "maxX" : 2478, "minY" : 0, "maxY" : 1070, "prop" : { "x" : 33, "y" : 0, "width" : 2445, "height" : 1070 }, "textPosition" : { "x" : 965, "y" : 15 }, "insets" : { "x" : 43, "y" : 10, "width" : 2425, "height" : 1050 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 51761, 51758, 51756, 51791 ] }, { "id" : 51761, "reactomeId" : 5460, "displayName" : "mitochondrial matrix", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1215, "y" : 601 }, "minX" : 95, "maxX" : 2335, "minY" : 206, "maxY" : 996, "prop" : { "x" : 95, "y" : 206, "width" : 2240, "height" : 790 }, "textPosition" : { "x" : 1431, "y" : 586 }, "insets" : { "x" : 105, "y" : 216, "width" : 2220, "height" : 770 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 51764, 51754, 51751, 51753, 51752, 51755, 51759, 51757, 51781, 51783, 51788, 51784, 51789, 51785, 51786, 51790, 51787 ] } ], "notes" : [ ], "links" : [ { "id" : 51788, "renderableClass" : "Interaction", "position" : { "x" : 503, "y" : 350 }, "minX" : 457, "maxX" : 549, "minY" : 298, "maxY" : 402, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 549, "y" : 402 }, "to" : { "x" : 457, "y" : 298 } } ], "endShape" : { "a" : { "x" : 465, "y" : 301 }, "b" : { "x" : 457, "y" : 298 }, "c" : { "x" : 459, "y" : 306 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 459, "y" : 306 } }, "reactionShape" : { "a" : { "x" : 497, "y" : 344 }, "b" : { "x" : 509, "y" : 356 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 503, "y" : 350 } }, "inputs" : [ { "id" : 51783 } ], "outputs" : [ { "id" : 51759 } ] }, { "id" : 51789, "renderableClass" : "Interaction", "position" : { "x" : 2133, "y" : 233 }, "minX" : 2050, "maxX" : 2217, "minY" : 222, "maxY" : 244, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2050, "y" : 244 }, "to" : { "x" : 2217, "y" : 222 } } ], "endShape" : { "a" : { "x" : 2211, "y" : 227 }, "b" : { "x" : 2217, "y" : 222 }, "c" : { "x" : 2210, "y" : 219 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2210, "y" : 219 } }, "reactionShape" : { "a" : { "x" : 2127, "y" : 227 }, "b" : { "x" : 2139, "y" : 239 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2133, "y" : 233 } }, "inputs" : [ { "id" : 51781 } ], "outputs" : [ { "id" : 51784 } ] }, { "id" : 51790, "renderableClass" : "Interaction", "position" : { "x" : 1432, "y" : 363 }, "minX" : 1426, "maxX" : 1438, "minY" : 315, "maxY" : 412, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1432, "y" : 412 }, "to" : { "x" : 1432, "y" : 315 } } ], "endShape" : { "a" : { "x" : 1436, "y" : 322 }, "b" : { "x" : 1432, "y" : 315 }, "c" : { "x" : 1428, "y" : 322 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1428, "y" : 322 } }, "reactionShape" : { "a" : { "x" : 1426, "y" : 357 }, "b" : { "x" : 1438, "y" : 369 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1432, "y" : 363 } }, "inputs" : [ { "id" : 51786 } ], "outputs" : [ { "id" : 51764 } ] }, { "id" : 51791, "renderableClass" : "Interaction", "position" : { "x" : 84, "y" : 439 }, "minX" : 73, "maxX" : 96, "minY" : 426, "maxY" : 453, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 73, "y" : 426 }, "to" : { "x" : 96, "y" : 453 } } ], "endShape" : { "a" : { "x" : 88, "y" : 450 }, "b" : { "x" : 96, "y" : 453 }, "c" : { "x" : 95, "y" : 445 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 95, "y" : 445 } }, "reactionShape" : { "a" : { "x" : 78, "y" : 433 }, "b" : { "x" : 90, "y" : 445 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 84, "y" : 439 } }, "inputs" : [ { "id" : 51787 } ], "outputs" : [ { "id" : 51752 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 2478, "minY" : 0, "maxY" : 1070, "disease" : false }