{
  "dbId" : 10331635,
  "stableId" : "R-CFA-9860927",
  "displayName" : "Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells",
  "nodes" : [ {
    "id" : 91649,
    "reactomeId" : 10244771,
    "displayName" : "PTK2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 541,
      "y" : 208
    },
    "minX" : 493,
    "maxX" : 572,
    "minY" : 189,
    "maxY" : 236,
    "prop" : {
      "x" : 517,
      "y" : 195,
      "width" : 49,
      "height" : 27
    },
    "textPosition" : {
      "x" : 522,
      "y" : 198
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 566,
          "y" : 195
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 566,
          "y" : 195
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91648,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 517,
          "y" : 225
        },
        "to" : {
          "x" : 493,
          "y" : 236
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91651,
    "reactomeId" : 10248947,
    "displayName" : "phospho-PTK2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 502,
      "y" : 423
    },
    "minX" : 382,
    "maxX" : 554,
    "minY" : 293,
    "maxY" : 439,
    "prop" : {
      "x" : 457,
      "y" : 412,
      "width" : 91,
      "height" : 22
    },
    "textPosition" : {
      "x" : 469,
      "y" : 406
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 548,
          "y" : 412
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 548,
          "y" : 412
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91648,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 501,
          "y" : 409
        },
        "to" : {
          "x" : 494,
          "y" : 293
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 497,
          "y" : 402
        },
        "b" : {
          "x" : 501,
          "y" : 409
        },
        "c" : {
          "x" : 505,
          "y" : 402
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 505,
          "y" : 402
        }
      }
    }, {
      "edgeId" : 91654,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 454,
          "y" : 427
        },
        "to" : {
          "x" : 390,
          "y" : 434
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 386,
          "y" : 435
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 386,
          "y" : 435
        }
      }
    } ]
  }, {
    "id" : 91650,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 466,
      "y" : 207
    },
    "minX" : 444,
    "maxX" : 493,
    "minY" : 190,
    "maxY" : 236,
    "prop" : {
      "x" : 444,
      "y" : 191,
      "width" : 44,
      "height" : 32
    },
    "textPosition" : {
      "x" : 450,
      "y" : 196
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 483,
          "y" : 196
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 483,
          "y" : 196
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91648,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 480,
          "y" : 226
        },
        "to" : {
          "x" : 493,
          "y" : 236
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91653,
    "reactomeId" : 10247156,
    "displayName" : "Integrin alphaVbeta3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 77,
      "y" : 374
    },
    "minX" : 0,
    "maxX" : 486,
    "minY" : 264,
    "maxY" : 386,
    "prop" : {
      "x" : 0,
      "y" : 362,
      "width" : 155,
      "height" : 24
    },
    "textPosition" : {
      "x" : 7,
      "y" : 365
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 155,
          "y" : 362
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 155,
          "y" : 362
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91648,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 122,
          "y" : 359
        },
        "to" : {
          "x" : 486,
          "y" : 266
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 480,
          "y" : 272
        },
        "b" : {
          "x" : 486,
          "y" : 266
        },
        "c" : {
          "x" : 478,
          "y" : 264
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 478,
          "y" : 264
        }
      }
    } ]
  }, {
    "id" : 91652,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 456,
      "y" : 314
    },
    "minX" : 439,
    "maxX" : 494,
    "minY" : 293,
    "maxY" : 329,
    "prop" : {
      "x" : 439,
      "y" : 299,
      "width" : 35,
      "height" : 30
    },
    "textPosition" : {
      "x" : 440,
      "y" : 303
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 469,
          "y" : 304
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 469,
          "y" : 304
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91648,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 477,
          "y" : 304
        },
        "to" : {
          "x" : 494,
          "y" : 293
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 481,
          "y" : 297
        },
        "b" : {
          "x" : 477,
          "y" : 304
        },
        "c" : {
          "x" : 485,
          "y" : 304
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 485,
          "y" : 304
        }
      }
    } ]
  }, {
    "id" : 91655,
    "reactomeId" : 10245377,
    "displayName" : "CHUK:IKBKB:IKBKG",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 309,
      "y" : 362
    },
    "minX" : 241,
    "maxX" : 384,
    "minY" : 344,
    "maxY" : 403,
    "prop" : {
      "x" : 241,
      "y" : 350,
      "width" : 137,
      "height" : 25
    },
    "textPosition" : {
      "x" : 251,
      "y" : 354
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 378,
          "y" : 350
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 378,
          "y" : 350
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91654,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 328,
          "y" : 378
        },
        "to" : {
          "x" : 374,
          "y" : 403
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91657,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 318,
      "y" : 480
    },
    "minX" : 301,
    "maxX" : 372,
    "minY" : 464,
    "maxY" : 495,
    "prop" : {
      "x" : 301,
      "y" : 465,
      "width" : 35,
      "height" : 30
    },
    "textPosition" : {
      "x" : 302,
      "y" : 469
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 331,
          "y" : 470
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 331,
          "y" : 470
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91654,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 339,
          "y" : 475
        },
        "to" : {
          "x" : 372,
          "y" : 467
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 349,
            "y" : 465
          },
          "b" : {
            "x" : 361,
            "y" : 477
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 355,
            "y" : 471
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 345,
          "y" : 469
        },
        "b" : {
          "x" : 339,
          "y" : 475
        },
        "c" : {
          "x" : 347,
          "y" : 477
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 347,
          "y" : 477
        }
      }
    } ]
  }, {
    "id" : 91656,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 418,
      "y" : 371
    },
    "minX" : 374,
    "maxX" : 437,
    "minY" : 355,
    "maxY" : 403,
    "prop" : {
      "x" : 401,
      "y" : 356,
      "width" : 35,
      "height" : 30
    },
    "textPosition" : {
      "x" : 403,
      "y" : 360
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 431,
          "y" : 361
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 431,
          "y" : 361
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91654,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 398,
          "y" : 383
        },
        "to" : {
          "x" : 374,
          "y" : 403
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 380,
            "y" : 387
          },
          "b" : {
            "x" : 392,
            "y" : 399
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 386,
            "y" : 393
          }
        }
      }
    } ]
  }, {
    "id" : 91658,
    "reactomeId" : 10325873,
    "displayName" : "p-Y187,Y198-CHUK:IKBKB:IKBKG",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 361,
      "y" : 523
    },
    "minX" : 249,
    "maxX" : 479,
    "minY" : 467,
    "maxY" : 537,
    "prop" : {
      "x" : 249,
      "y" : 509,
      "width" : 224,
      "height" : 28
    },
    "textPosition" : {
      "x" : 262,
      "y" : 516
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 473,
          "y" : 509
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 473,
          "y" : 509
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91654,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 363,
          "y" : 506
        },
        "to" : {
          "x" : 372,
          "y" : 467
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 361,
          "y" : 498
        },
        "b" : {
          "x" : 363,
          "y" : 506
        },
        "c" : {
          "x" : 368,
          "y" : 500
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 368,
          "y" : 500
        }
      }
    } ]
  }, {
    "id" : 91661,
    "reactomeId" : 10323776,
    "displayName" : "IKBKE:IKBKE",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 131,
      "y" : 586
    },
    "minX" : 83,
    "maxX" : 185,
    "minY" : 568,
    "maxY" : 631,
    "prop" : {
      "x" : 83,
      "y" : 574,
      "width" : 96,
      "height" : 25
    },
    "textPosition" : {
      "x" : 92,
      "y" : 578
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 179,
          "y" : 574
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 179,
          "y" : 574
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91659,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 128,
          "y" : 602
        },
        "to" : {
          "x" : 121,
          "y" : 631
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91660,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 58,
      "y" : 622
    },
    "minX" : 41,
    "maxX" : 121,
    "minY" : 606,
    "maxY" : 637,
    "prop" : {
      "x" : 41,
      "y" : 607,
      "width" : 35,
      "height" : 30
    },
    "textPosition" : {
      "x" : 43,
      "y" : 611
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 71,
          "y" : 612
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 71,
          "y" : 612
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91659,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 79,
          "y" : 624
        },
        "to" : {
          "x" : 121,
          "y" : 631
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 94,
            "y" : 621
          },
          "b" : {
            "x" : 106,
            "y" : 633
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 100,
            "y" : 627
          }
        }
      }
    } ]
  }, {
    "id" : 91663,
    "reactomeId" : 10232908,
    "displayName" : "p-S172-IKBKE:p-S172-IKBKE",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 166,
      "y" : 716
    },
    "minX" : 120,
    "maxX" : 219,
    "minY" : 673,
    "maxY" : 788,
    "prop" : {
      "x" : 120,
      "y" : 698,
      "width" : 93,
      "height" : 36
    },
    "textPosition" : {
      "x" : 120,
      "y" : 699
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 213,
          "y" : 698
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 213,
          "y" : 698
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91659,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 146,
          "y" : 695
        },
        "to" : {
          "x" : 120,
          "y" : 673
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 138,
          "y" : 694
        },
        "b" : {
          "x" : 146,
          "y" : 695
        },
        "c" : {
          "x" : 143,
          "y" : 687
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 143,
          "y" : 687
        }
      }
    }, {
      "edgeId" : 91664,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 167,
          "y" : 737
        },
        "to" : {
          "x" : 170,
          "y" : 788
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 166,
          "y" : 781
        },
        "b" : {
          "x" : 170,
          "y" : 788
        },
        "c" : {
          "x" : 174,
          "y" : 781
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 174,
          "y" : 781
        }
      }
    } ]
  }, {
    "id" : 91662,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 63,
      "y" : 700
    },
    "minX" : 46,
    "maxX" : 120,
    "minY" : 673,
    "maxY" : 715,
    "prop" : {
      "x" : 46,
      "y" : 685,
      "width" : 35,
      "height" : 30
    },
    "textPosition" : {
      "x" : 47,
      "y" : 689
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 76,
          "y" : 690
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 76,
          "y" : 690
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91659,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 84,
          "y" : 691
        },
        "to" : {
          "x" : 120,
          "y" : 673
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 96,
            "y" : 676
          },
          "b" : {
            "x" : 108,
            "y" : 688
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 102,
            "y" : 682
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 88,
          "y" : 684
        },
        "b" : {
          "x" : 84,
          "y" : 691
        },
        "c" : {
          "x" : 92,
          "y" : 691
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 92,
          "y" : 691
        }
      }
    } ]
  }, {
    "id" : 91665,
    "reactomeId" : 10252150,
    "displayName" : "STAT1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 75,
      "y" : 772
    },
    "minX" : 45,
    "maxX" : 134,
    "minY" : 755,
    "maxY" : 797,
    "prop" : {
      "x" : 45,
      "y" : 761,
      "width" : 61,
      "height" : 22
    },
    "textPosition" : {
      "x" : 52,
      "y" : 761
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 106,
          "y" : 761
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 106,
          "y" : 761
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91664,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 100,
          "y" : 786
        },
        "to" : {
          "x" : 134,
          "y" : 797
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91667,
    "reactomeId" : 10315654,
    "displayName" : "phospho-STAT1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 260,
      "y" : 763
    },
    "minX" : 204,
    "maxX" : 323,
    "minY" : 745,
    "maxY" : 798,
    "prop" : {
      "x" : 204,
      "y" : 751,
      "width" : 113,
      "height" : 24
    },
    "textPosition" : {
      "x" : 208,
      "y" : 752
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 317,
          "y" : 751
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 317,
          "y" : 751
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91664,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 242,
          "y" : 778
        },
        "to" : {
          "x" : 209,
          "y" : 798
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 238,
          "y" : 785
        },
        "b" : {
          "x" : 242,
          "y" : 778
        },
        "c" : {
          "x" : 234,
          "y" : 778
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 234,
          "y" : 778
        }
      }
    }, {
      "edgeId" : 91669,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 281,
            "y" : 784
          },
          "b" : {
            "x" : 293,
            "y" : 796
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 287,
            "y" : 790
          }
        }
      }
    } ]
  }, {
    "id" : 91666,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 90,
      "y" : 833
    },
    "minX" : 73,
    "maxX" : 134,
    "minY" : 797,
    "maxY" : 848,
    "prop" : {
      "x" : 73,
      "y" : 818,
      "width" : 35,
      "height" : 30
    },
    "textPosition" : {
      "x" : 75,
      "y" : 822
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 103,
          "y" : 823
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 103,
          "y" : 823
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91664,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 111,
          "y" : 818
        },
        "to" : {
          "x" : 134,
          "y" : 797
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91668,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 246,
      "y" : 839
    },
    "minX" : 209,
    "maxX" : 268,
    "minY" : 798,
    "maxY" : 855,
    "prop" : {
      "x" : 226,
      "y" : 823,
      "width" : 41,
      "height" : 32
    },
    "textPosition" : {
      "x" : 230,
      "y" : 828
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 262,
          "y" : 828
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 262,
          "y" : 828
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91664,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 231,
          "y" : 820
        },
        "to" : {
          "x" : 209,
          "y" : 798
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 223,
          "y" : 818
        },
        "b" : {
          "x" : 231,
          "y" : 820
        },
        "c" : {
          "x" : 229,
          "y" : 812
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 229,
          "y" : 812
        }
      }
    } ]
  }, {
    "id" : 91670,
    "reactomeId" : 10315676,
    "displayName" : "p-Y-STAT1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 344,
      "y" : 844
    },
    "minX" : 287,
    "maxX" : 408,
    "minY" : 825,
    "maxY" : 857,
    "prop" : {
      "x" : 287,
      "y" : 831,
      "width" : 115,
      "height" : 26
    },
    "textPosition" : {
      "x" : 290,
      "y" : 836
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 402,
          "y" : 831
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 402,
          "y" : 831
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91669,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 91671,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91672,
    "reactomeId" : 10315696,
    "displayName" : "2xp-Y-STAT1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 526,
      "y" : 844
    },
    "minX" : 476,
    "maxX" : 583,
    "minY" : 826,
    "maxY" : 857,
    "prop" : {
      "x" : 476,
      "y" : 832,
      "width" : 101,
      "height" : 25
    },
    "textPosition" : {
      "x" : 485,
      "y" : 836
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 577,
          "y" : 832
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 577,
          "y" : 832
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91671,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91619,
    "reactomeId" : 10325904,
    "displayName" : "Calpain2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 174,
      "y" : 139
    },
    "minX" : 134,
    "maxX" : 243,
    "minY" : 120,
    "maxY" : 153,
    "prop" : {
      "x" : 134,
      "y" : 126,
      "width" : 81,
      "height" : 27
    },
    "textPosition" : {
      "x" : 143,
      "y" : 132
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 215,
          "y" : 126
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 215,
          "y" : 126
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91617,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 218,
          "y" : 147
        },
        "to" : {
          "x" : 243,
          "y" : 153
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91618,
    "reactomeId" : 74016,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 438,
      "y" : 139
    },
    "minX" : 243,
    "maxX" : 1149,
    "minY" : 76,
    "maxY" : 154,
    "prop" : {
      "x" : 411,
      "y" : 124,
      "width" : 54,
      "height" : 30
    },
    "textPosition" : {
      "x" : 417,
      "y" : 128
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 460,
          "y" : 129
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 460,
          "y" : 129
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91617,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 408,
          "y" : 140
        },
        "to" : {
          "x" : 243,
          "y" : 153
        }
      } ],
      "stoichiometry" : {
        "value" : 7,
        "shape" : {
          "a" : {
            "x" : 319,
            "y" : 140
          },
          "b" : {
            "x" : 331,
            "y" : 152
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 325,
            "y" : 146
          }
        }
      }
    }, {
      "edgeId" : 91624,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 468,
          "y" : 135
        },
        "to" : {
          "x" : 826,
          "y" : 95
        }
      }, {
        "from" : {
          "x" : 826,
          "y" : 95
        },
        "to" : {
          "x" : 844,
          "y" : 76
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 842,
          "y" : 84
        },
        "b" : {
          "x" : 844,
          "y" : 76
        },
        "c" : {
          "x" : 836,
          "y" : 78
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 836,
          "y" : 78
        }
      }
    }, {
      "edgeId" : 91630,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 468,
          "y" : 136
        },
        "to" : {
          "x" : 1149,
          "y" : 83
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91620,
    "reactomeId" : 10325899,
    "displayName" : "Calpain2:Ca2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 245,
      "y" : 240
    },
    "minX" : 119,
    "maxX" : 308,
    "minY" : 219,
    "maxY" : 256,
    "prop" : {
      "x" : 188,
      "y" : 225,
      "width" : 114,
      "height" : 31
    },
    "textPosition" : {
      "x" : 195,
      "y" : 235
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 302,
          "y" : 225
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 302,
          "y" : 225
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91617,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 91621,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 185,
          "y" : 244
        },
        "to" : {
          "x" : 127,
          "y" : 249
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 123,
          "y" : 250
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 123,
          "y" : 250
        }
      }
    } ]
  }, {
    "id" : 91623,
    "reactomeId" : 10325891,
    "displayName" : "VCL",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 113,
      "y" : 291
    },
    "minX" : 60,
    "maxX" : 173,
    "minY" : 270,
    "maxY" : 307,
    "prop" : {
      "x" : 60,
      "y" : 276,
      "width" : 107,
      "height" : 31
    },
    "textPosition" : {
      "x" : 98,
      "y" : 281
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 167,
          "y" : 276
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 167,
          "y" : 276
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91621,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91622,
    "reactomeId" : 10257530,
    "displayName" : "VCL",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 108,
      "y" : 214
    },
    "minX" : 88,
    "maxX" : 135,
    "minY" : 195,
    "maxY" : 227,
    "prop" : {
      "x" : 88,
      "y" : 201,
      "width" : 41,
      "height" : 26
    },
    "textPosition" : {
      "x" : 93,
      "y" : 203
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 129,
          "y" : 201
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 129,
          "y" : 201
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91621,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91625,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 775,
      "y" : 35
    },
    "minX" : 750,
    "maxX" : 803,
    "minY" : 16,
    "maxY" : 69,
    "prop" : {
      "x" : 750,
      "y" : 17,
      "width" : 51,
      "height" : 37
    },
    "textPosition" : {
      "x" : 758,
      "y" : 25
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 796,
          "y" : 22
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 796,
          "y" : 22
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91624,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 790,
          "y" : 57
        },
        "to" : {
          "x" : 803,
          "y" : 69
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 91627,
    "reactomeId" : 10325883,
    "displayName" : "phospho-ANXA2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1061,
      "y" : 62
    },
    "minX" : 885,
    "maxX" : 1149,
    "minY" : 43,
    "maxY" : 83,
    "prop" : {
      "x" : 1007,
      "y" : 49,
      "width" : 108,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1007,
      "y" : 52
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1115,
          "y" : 49
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1115,
          "y" : 49
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91624,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1004,
          "y" : 63
        },
        "to" : {
          "x" : 885,
          "y" : 68
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 997,
          "y" : 67
        },
        "b" : {
          "x" : 1004,
          "y" : 63
        },
        "c" : {
          "x" : 997,
          "y" : 59
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 997,
          "y" : 59
        }
      }
    }, {
      "edgeId" : 91630,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1118,
          "y" : 74
        },
        "to" : {
          "x" : 1149,
          "y" : 83
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91626,
    "reactomeId" : 10325991,
    "displayName" : "phospho-ANXA2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 677,
      "y" : 74
    },
    "minX" : 612,
    "maxX" : 803,
    "minY" : 51,
    "maxY" : 91,
    "prop" : {
      "x" : 612,
      "y" : 57,
      "width" : 131,
      "height" : 34
    },
    "textPosition" : {
      "x" : 624,
      "y" : 63
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 743,
          "y" : 57
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 743,
          "y" : 57
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91624,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 746,
          "y" : 71
        },
        "to" : {
          "x" : 803,
          "y" : 69
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91629,
    "reactomeId" : 10250308,
    "displayName" : "PTPN1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 846,
      "y" : 30
    },
    "minX" : 818,
    "maxX" : 881,
    "minY" : 10,
    "maxY" : 62,
    "prop" : {
      "x" : 818,
      "y" : 16,
      "width" : 57,
      "height" : 29
    },
    "textPosition" : {
      "x" : 822,
      "y" : 20
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 875,
          "y" : 16
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 875,
          "y" : 16
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91624,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 847,
          "y" : 48
        },
        "to" : {
          "x" : 848,
          "y" : 54
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 848,
          "y" : 58
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 848,
          "y" : 58
        }
      }
    } ]
  }, {
    "id" : 91628,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 923,
      "y" : 36
    },
    "minX" : 885,
    "maxX" : 943,
    "minY" : 18,
    "maxY" : 68,
    "prop" : {
      "x" : 905,
      "y" : 19,
      "width" : 37,
      "height" : 35
    },
    "textPosition" : {
      "x" : 914,
      "y" : 26
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 937,
          "y" : 24
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 937,
          "y" : 24
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91624,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 902,
          "y" : 51
        },
        "to" : {
          "x" : 885,
          "y" : 68
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 900,
          "y" : 59
        },
        "b" : {
          "x" : 902,
          "y" : 51
        },
        "c" : {
          "x" : 894,
          "y" : 53
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 894,
          "y" : 53
        }
      }
    } ]
  }, {
    "id" : 91631,
    "reactomeId" : 10325880,
    "displayName" : "ITGA5:ITGB1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1169,
      "y" : 32
    },
    "minX" : 1121,
    "maxX" : 1223,
    "minY" : 14,
    "maxY" : 83,
    "prop" : {
      "x" : 1121,
      "y" : 20,
      "width" : 96,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1128,
      "y" : 24
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1217,
          "y" : 20
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1217,
          "y" : 20
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91630,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1164,
          "y" : 48
        },
        "to" : {
          "x" : 1149,
          "y" : 83
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91632,
    "reactomeId" : 10326006,
    "displayName" : "p-S26-ANXA2:ITGA5:ITGB1:Ca2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1152,
      "y" : 149
    },
    "minX" : 1088,
    "maxX" : 1222,
    "minY" : 124,
    "maxY" : 169,
    "prop" : {
      "x" : 1088,
      "y" : 130,
      "width" : 128,
      "height" : 39
    },
    "textPosition" : {
      "x" : 1092,
      "y" : 134
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1216,
          "y" : 130
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1216,
          "y" : 130
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91630,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91635,
    "reactomeId" : 10275261,
    "displayName" : "phospho-p-S127-YAP1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 817,
      "y" : 512
    },
    "minX" : 768,
    "maxX" : 873,
    "minY" : 493,
    "maxY" : 552,
    "prop" : {
      "x" : 768,
      "y" : 499,
      "width" : 99,
      "height" : 26
    },
    "textPosition" : {
      "x" : 778,
      "y" : 495
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 867,
          "y" : 499
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 867,
          "y" : 499
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91633,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 830,
          "y" : 528
        },
        "to" : {
          "x" : 858,
          "y" : 552
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91634,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 896,
      "y" : 511
    },
    "minX" : 858,
    "maxX" : 915,
    "minY" : 495,
    "maxY" : 552,
    "prop" : {
      "x" : 879,
      "y" : 496,
      "width" : 35,
      "height" : 30
    },
    "textPosition" : {
      "x" : 879,
      "y" : 500
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 909,
          "y" : 501
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 909,
          "y" : 501
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91633,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 882,
          "y" : 529
        },
        "to" : {
          "x" : 858,
          "y" : 552
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 91637,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 916,
      "y" : 664
    },
    "minX" : 859,
    "maxX" : 936,
    "minY" : 637,
    "maxY" : 682,
    "prop" : {
      "x" : 898,
      "y" : 647,
      "width" : 37,
      "height" : 35
    },
    "textPosition" : {
      "x" : 907,
      "y" : 654
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 930,
          "y" : 652
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 930,
          "y" : 652
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91633,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 895,
          "y" : 655
        },
        "to" : {
          "x" : 859,
          "y" : 637
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 887,
          "y" : 655
        },
        "b" : {
          "x" : 895,
          "y" : 655
        },
        "c" : {
          "x" : 891,
          "y" : 648
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 891,
          "y" : 648
        }
      }
    } ]
  }, {
    "id" : 91636,
    "reactomeId" : 10266646,
    "displayName" : "YAP1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 828,
      "y" : 670
    },
    "minX" : 801,
    "maxX" : 861,
    "minY" : 637,
    "maxY" : 683,
    "prop" : {
      "x" : 801,
      "y" : 658,
      "width" : 54,
      "height" : 25
    },
    "textPosition" : {
      "x" : 808,
      "y" : 660
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 855,
          "y" : 658
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 855,
          "y" : 658
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91633,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 839,
          "y" : 655
        },
        "to" : {
          "x" : 859,
          "y" : 637
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 841,
          "y" : 647
        },
        "b" : {
          "x" : 839,
          "y" : 655
        },
        "c" : {
          "x" : 847,
          "y" : 653
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 847,
          "y" : 653
        }
      }
    }, {
      "edgeId" : 91644,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91638,
    "reactomeId" : 10326017,
    "displayName" : "p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1159,
      "y" : 584
    },
    "minX" : 867,
    "maxX" : 1278,
    "minY" : 561,
    "maxY" : 602,
    "prop" : {
      "x" : 1046,
      "y" : 567,
      "width" : 226,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1055,
      "y" : 567
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1272,
          "y" : 567
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1272,
          "y" : 567
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91633,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1043,
          "y" : 584
        },
        "to" : {
          "x" : 875,
          "y" : 585
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 871,
          "y" : 585
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 871,
          "y" : 585
        }
      }
    } ]
  }, {
    "id" : 91641,
    "reactomeId" : 10250035,
    "displayName" : "ABL1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 760,
      "y" : 377
    },
    "minX" : 736,
    "maxX" : 788,
    "minY" : 359,
    "maxY" : 422,
    "prop" : {
      "x" : 738,
      "y" : 365,
      "width" : 44,
      "height" : 25
    },
    "textPosition" : {
      "x" : 741,
      "y" : 367
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 782,
          "y" : 365
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 782,
          "y" : 365
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91639,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 753,
          "y" : 393
        },
        "to" : {
          "x" : 736,
          "y" : 422
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91640,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 700,
      "y" : 386
    },
    "minX" : 680,
    "maxX" : 736,
    "minY" : 369,
    "maxY" : 422,
    "prop" : {
      "x" : 680,
      "y" : 370,
      "width" : 40,
      "height" : 32
    },
    "textPosition" : {
      "x" : 684,
      "y" : 375
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 715,
          "y" : 375
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 715,
          "y" : 375
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91639,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 716,
          "y" : 405
        },
        "to" : {
          "x" : 736,
          "y" : 422
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91643,
    "reactomeId" : 10325885,
    "displayName" : "p-S26-ANXA2:ITGA5:ITGB1:Ca2+:fibronectin",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1156,
      "y" : 260
    },
    "minX" : 504,
    "maxX" : 1245,
    "minY" : 235,
    "maxY" : 465,
    "prop" : {
      "x" : 1073,
      "y" : 241,
      "width" : 166,
      "height" : 38
    },
    "textPosition" : {
      "x" : 1080,
      "y" : 244
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1239,
          "y" : 241
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1239,
          "y" : 241
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91648,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 1070,
          "y" : 260
        },
        "to" : {
          "x" : 504,
          "y" : 264
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 511,
          "y" : 260
        },
        "b" : {
          "x" : 504,
          "y" : 264
        },
        "c" : {
          "x" : 511,
          "y" : 268
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 511,
          "y" : 268
        }
      }
    }, {
      "edgeId" : 91639,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 1070,
          "y" : 262
        },
        "to" : {
          "x" : 836,
          "y" : 270
        }
      }, {
        "from" : {
          "x" : 836,
          "y" : 270
        },
        "to" : {
          "x" : 789,
          "y" : 461
        }
      }, {
        "from" : {
          "x" : 789,
          "y" : 461
        },
        "to" : {
          "x" : 744,
          "y" : 461
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 751,
          "y" : 457
        },
        "b" : {
          "x" : 744,
          "y" : 461
        },
        "c" : {
          "x" : 751,
          "y" : 465
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 751,
          "y" : 465
        }
      }
    } ]
  }, {
    "id" : 91642,
    "reactomeId" : 10325999,
    "displayName" : "phospho-p-Y393-ABL1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 737,
      "y" : 577
    },
    "minX" : 692,
    "maxX" : 788,
    "minY" : 559,
    "maxY" : 659,
    "prop" : {
      "x" : 692,
      "y" : 565,
      "width" : 90,
      "height" : 25
    },
    "textPosition" : {
      "x" : 697,
      "y" : 560
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 782,
          "y" : 565
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 782,
          "y" : 565
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91639,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 91644,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 737,
          "y" : 593
        },
        "to" : {
          "x" : 739,
          "y" : 651
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 740,
          "y" : 655
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 740,
          "y" : 655
        }
      }
    } ]
  }, {
    "id" : 91645,
    "reactomeId" : 10325995,
    "displayName" : "phospho-p-Y407-YAP1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 665,
      "y" : 671
    },
    "minX" : 619,
    "maxX" : 717,
    "minY" : 651,
    "maxY" : 685,
    "prop" : {
      "x" : 619,
      "y" : 657,
      "width" : 92,
      "height" : 28
    },
    "textPosition" : {
      "x" : 625,
      "y" : 654
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 711,
          "y" : 657
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 711,
          "y" : 657
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91644,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 91646,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91647,
    "reactomeId" : 10314919,
    "displayName" : "phospho-p-Y407-YAP1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 767,
      "y" : 771
    },
    "minX" : 717,
    "maxX" : 824,
    "minY" : 753,
    "maxY" : 783,
    "prop" : {
      "x" : 717,
      "y" : 759,
      "width" : 101,
      "height" : 24
    },
    "textPosition" : {
      "x" : 728,
      "y" : 754
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 818,
          "y" : 759
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 818,
          "y" : 759
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91646,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 91617,
    "reactomeId" : 10325906,
    "displayName" : "Ca2+ activates Calpain2 (m-Calpain)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 244,
      "y" : 185
    },
    "minX" : 238,
    "maxX" : 250,
    "minY" : 153,
    "maxY" : 222,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 243,
        "y" : 153
      },
      "to" : {
        "x" : 244,
        "y" : 185
      }
    }, {
      "from" : {
        "x" : 244,
        "y" : 185
      },
      "to" : {
        "x" : 244,
        "y" : 222
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 240,
        "y" : 215
      },
      "b" : {
        "x" : 244,
        "y" : 222
      },
      "c" : {
        "x" : 248,
        "y" : 215
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 248,
        "y" : 215
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 244,
        "y" : 185
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 244,
        "y" : 185
      }
    },
    "inputs" : [ {
      "id" : 91618,
      "points" : [ {
        "x" : 408,
        "y" : 140
      } ],
      "stoichiometry" : 7
    }, {
      "id" : 91619,
      "points" : [ {
        "x" : 218,
        "y" : 147
      } ]
    } ],
    "outputs" : [ {
      "id" : 91620
    } ]
  }, {
    "id" : 91648,
    "reactomeId" : 10325887,
    "displayName" : "Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 495,
      "y" : 264
    },
    "minX" : 489,
    "maxX" : 501,
    "minY" : 236,
    "maxY" : 293,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 493,
        "y" : 236
      },
      "to" : {
        "x" : 495,
        "y" : 264
      }
    }, {
      "from" : {
        "x" : 495,
        "y" : 264
      },
      "to" : {
        "x" : 494,
        "y" : 293
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 489,
        "y" : 258
      },
      "b" : {
        "x" : 501,
        "y" : 270
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 495,
        "y" : 264
      }
    },
    "inputs" : [ {
      "id" : 91649,
      "points" : [ {
        "x" : 517,
        "y" : 225
      } ]
    }, {
      "id" : 91650,
      "points" : [ {
        "x" : 480,
        "y" : 226
      } ]
    } ],
    "outputs" : [ {
      "id" : 91651,
      "points" : [ {
        "x" : 501,
        "y" : 409
      } ]
    }, {
      "id" : 91652,
      "points" : [ {
        "x" : 477,
        "y" : 304
      } ]
    } ],
    "activators" : [ {
      "id" : 91653,
      "points" : [ {
        "x" : 122,
        "y" : 359
      } ]
    }, {
      "id" : 91643,
      "points" : [ {
        "x" : 1070,
        "y" : 260
      } ]
    } ]
  }, {
    "id" : 91621,
    "reactomeId" : 10325902,
    "displayName" : "Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 111,
      "y" : 251
    },
    "minX" : 105,
    "maxX" : 117,
    "minY" : 230,
    "maxY" : 273,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 109,
        "y" : 230
      },
      "to" : {
        "x" : 111,
        "y" : 251
      }
    }, {
      "from" : {
        "x" : 111,
        "y" : 251
      },
      "to" : {
        "x" : 112,
        "y" : 273
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 108,
        "y" : 266
      },
      "b" : {
        "x" : 112,
        "y" : 273
      },
      "c" : {
        "x" : 116,
        "y" : 266
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 116,
        "y" : 266
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 105,
        "y" : 245
      },
      "b" : {
        "x" : 117,
        "y" : 257
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 111,
        "y" : 251
      }
    },
    "inputs" : [ {
      "id" : 91622
    } ],
    "outputs" : [ {
      "id" : 91623
    } ],
    "catalysts" : [ {
      "id" : 91620,
      "points" : [ {
        "x" : 185,
        "y" : 244
      } ]
    } ]
  }, {
    "id" : 91654,
    "reactomeId" : 10325876,
    "displayName" : "p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 374,
      "y" : 436
    },
    "minX" : 368,
    "maxX" : 380,
    "minY" : 403,
    "maxY" : 467,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 374,
        "y" : 403
      },
      "to" : {
        "x" : 374,
        "y" : 436
      }
    }, {
      "from" : {
        "x" : 374,
        "y" : 436
      },
      "to" : {
        "x" : 372,
        "y" : 467
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 368,
        "y" : 430
      },
      "b" : {
        "x" : 380,
        "y" : 442
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 374,
        "y" : 436
      }
    },
    "inputs" : [ {
      "id" : 91655,
      "points" : [ {
        "x" : 328,
        "y" : 378
      } ]
    }, {
      "id" : 91656,
      "points" : [ {
        "x" : 398,
        "y" : 383
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 91657,
      "points" : [ {
        "x" : 339,
        "y" : 475
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 91658,
      "points" : [ {
        "x" : 363,
        "y" : 506
      } ]
    } ],
    "catalysts" : [ {
      "id" : 91651,
      "points" : [ {
        "x" : 454,
        "y" : 427
      } ]
    } ]
  }, {
    "id" : 91624,
    "reactomeId" : 10325993,
    "displayName" : "PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 850,
      "y" : 70
    },
    "minX" : 803,
    "maxX" : 885,
    "minY" : 64,
    "maxY" : 76,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 803,
        "y" : 69
      },
      "to" : {
        "x" : 850,
        "y" : 70
      }
    }, {
      "from" : {
        "x" : 850,
        "y" : 70
      },
      "to" : {
        "x" : 885,
        "y" : 68
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 844,
        "y" : 64
      },
      "b" : {
        "x" : 856,
        "y" : 76
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 850,
        "y" : 70
      }
    },
    "inputs" : [ {
      "id" : 91625,
      "points" : [ {
        "x" : 790,
        "y" : 57
      } ]
    }, {
      "id" : 91626,
      "points" : [ {
        "x" : 746,
        "y" : 71
      } ]
    } ],
    "outputs" : [ {
      "id" : 91627,
      "points" : [ {
        "x" : 1004,
        "y" : 63
      } ]
    }, {
      "id" : 91628,
      "points" : [ {
        "x" : 902,
        "y" : 51
      } ]
    } ],
    "catalysts" : [ {
      "id" : 91629,
      "points" : [ {
        "x" : 847,
        "y" : 48
      } ]
    } ],
    "activators" : [ {
      "id" : 91618,
      "points" : [ {
        "x" : 468,
        "y" : 135
      }, {
        "x" : 826,
        "y" : 95
      } ]
    } ]
  }, {
    "id" : 91659,
    "reactomeId" : 10326109,
    "displayName" : "Phosphorylation of IKBKE on serine-172 in response to low shear stress",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 120,
      "y" : 653
    },
    "minX" : 114,
    "maxX" : 126,
    "minY" : 631,
    "maxY" : 673,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 121,
        "y" : 631
      },
      "to" : {
        "x" : 120,
        "y" : 653
      }
    }, {
      "from" : {
        "x" : 120,
        "y" : 653
      },
      "to" : {
        "x" : 120,
        "y" : 673
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 114,
        "y" : 647
      },
      "b" : {
        "x" : 126,
        "y" : 659
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 120,
        "y" : 653
      }
    },
    "inputs" : [ {
      "id" : 91660,
      "points" : [ {
        "x" : 79,
        "y" : 624
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 91661,
      "points" : [ {
        "x" : 128,
        "y" : 602
      } ]
    } ],
    "outputs" : [ {
      "id" : 91662,
      "points" : [ {
        "x" : 84,
        "y" : 691
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 91663,
      "points" : [ {
        "x" : 146,
        "y" : 695
      } ]
    } ]
  }, {
    "id" : 91630,
    "reactomeId" : 10326008,
    "displayName" : "p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1150,
      "y" : 102
    },
    "minX" : 1144,
    "maxX" : 1156,
    "minY" : 83,
    "maxY" : 127,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1149,
        "y" : 83
      },
      "to" : {
        "x" : 1150,
        "y" : 102
      }
    }, {
      "from" : {
        "x" : 1150,
        "y" : 102
      },
      "to" : {
        "x" : 1151,
        "y" : 127
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1147,
        "y" : 120
      },
      "b" : {
        "x" : 1151,
        "y" : 127
      },
      "c" : {
        "x" : 1155,
        "y" : 120
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1155,
        "y" : 120
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1150,
        "y" : 102
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1150,
        "y" : 102
      }
    },
    "inputs" : [ {
      "id" : 91618,
      "points" : [ {
        "x" : 468,
        "y" : 136
      } ]
    }, {
      "id" : 91631,
      "points" : [ {
        "x" : 1164,
        "y" : 48
      } ]
    }, {
      "id" : 91627,
      "points" : [ {
        "x" : 1118,
        "y" : 74
      } ]
    } ],
    "outputs" : [ {
      "id" : 91632
    } ]
  }, {
    "id" : 91633,
    "reactomeId" : 10326020,
    "displayName" : "PP2A dephosphorylates serine-127 of YAP1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 859,
      "y" : 585
    },
    "minX" : 853,
    "maxX" : 865,
    "minY" : 552,
    "maxY" : 637,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 858,
        "y" : 552
      },
      "to" : {
        "x" : 859,
        "y" : 585
      }
    }, {
      "from" : {
        "x" : 859,
        "y" : 585
      },
      "to" : {
        "x" : 859,
        "y" : 637
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 853,
        "y" : 579
      },
      "b" : {
        "x" : 865,
        "y" : 591
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 859,
        "y" : 585
      }
    },
    "inputs" : [ {
      "id" : 91634,
      "points" : [ {
        "x" : 882,
        "y" : 529
      } ]
    }, {
      "id" : 91635,
      "points" : [ {
        "x" : 830,
        "y" : 528
      } ]
    } ],
    "outputs" : [ {
      "id" : 91636,
      "points" : [ {
        "x" : 839,
        "y" : 655
      } ]
    }, {
      "id" : 91637,
      "points" : [ {
        "x" : 895,
        "y" : 655
      } ]
    } ],
    "catalysts" : [ {
      "id" : 91638,
      "points" : [ {
        "x" : 1043,
        "y" : 584
      } ]
    } ]
  }, {
    "id" : 91664,
    "reactomeId" : 10326111,
    "displayName" : "Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 171,
      "y" : 797
    },
    "minX" : 134,
    "maxX" : 209,
    "minY" : 791,
    "maxY" : 803,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 134,
        "y" : 797
      },
      "to" : {
        "x" : 171,
        "y" : 797
      }
    }, {
      "from" : {
        "x" : 171,
        "y" : 797
      },
      "to" : {
        "x" : 209,
        "y" : 798
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 165,
        "y" : 791
      },
      "b" : {
        "x" : 177,
        "y" : 803
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 171,
        "y" : 797
      }
    },
    "inputs" : [ {
      "id" : 91665,
      "points" : [ {
        "x" : 100,
        "y" : 786
      } ]
    }, {
      "id" : 91666,
      "points" : [ {
        "x" : 111,
        "y" : 818
      } ]
    } ],
    "outputs" : [ {
      "id" : 91667,
      "points" : [ {
        "x" : 242,
        "y" : 778
      } ]
    }, {
      "id" : 91668,
      "points" : [ {
        "x" : 231,
        "y" : 820
      } ]
    } ],
    "activators" : [ {
      "id" : 91663,
      "points" : [ {
        "x" : 167,
        "y" : 737
      } ]
    } ]
  }, {
    "id" : 91669,
    "reactomeId" : 10315678,
    "displayName" : "p-Y701-STAT1 dimerizes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 302,
      "y" : 803
    },
    "minX" : 272,
    "maxX" : 330,
    "minY" : 778,
    "maxY" : 828,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 272,
        "y" : 778
      },
      "to" : {
        "x" : 302,
        "y" : 803
      }
    }, {
      "from" : {
        "x" : 302,
        "y" : 803
      },
      "to" : {
        "x" : 330,
        "y" : 828
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 322,
        "y" : 826
      },
      "b" : {
        "x" : 330,
        "y" : 828
      },
      "c" : {
        "x" : 327,
        "y" : 820
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 327,
        "y" : 820
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 302,
        "y" : 803
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 302,
        "y" : 803
      }
    },
    "inputs" : [ {
      "id" : 91667,
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 91670
    } ]
  }, {
    "id" : 91639,
    "reactomeId" : 10326001,
    "displayName" : "Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 735,
      "y" : 461
    },
    "minX" : 729,
    "maxX" : 741,
    "minY" : 422,
    "maxY" : 562,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 736,
        "y" : 422
      },
      "to" : {
        "x" : 735,
        "y" : 461
      }
    }, {
      "from" : {
        "x" : 735,
        "y" : 461
      },
      "to" : {
        "x" : 736,
        "y" : 562
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 732,
        "y" : 555
      },
      "b" : {
        "x" : 736,
        "y" : 562
      },
      "c" : {
        "x" : 740,
        "y" : 555
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 740,
        "y" : 555
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 729,
        "y" : 455
      },
      "b" : {
        "x" : 741,
        "y" : 467
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 735,
        "y" : 461
      }
    },
    "inputs" : [ {
      "id" : 91640,
      "points" : [ {
        "x" : 716,
        "y" : 405
      } ]
    }, {
      "id" : 91641,
      "points" : [ {
        "x" : 753,
        "y" : 393
      } ]
    } ],
    "outputs" : [ {
      "id" : 91642
    } ],
    "activators" : [ {
      "id" : 91643,
      "points" : [ {
        "x" : 1070,
        "y" : 262
      }, {
        "x" : 836,
        "y" : 270
      }, {
        "x" : 789,
        "y" : 461
      } ]
    } ]
  }, {
    "id" : 91671,
    "reactomeId" : 10315698,
    "displayName" : "p-Y701-STAT1 dimer translocates from the cytosol to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 434,
      "y" : 845
    },
    "minX" : 405,
    "maxX" : 473,
    "minY" : 839,
    "maxY" : 851,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 405,
        "y" : 844
      },
      "to" : {
        "x" : 434,
        "y" : 845
      }
    }, {
      "from" : {
        "x" : 434,
        "y" : 845
      },
      "to" : {
        "x" : 473,
        "y" : 844
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 466,
        "y" : 848
      },
      "b" : {
        "x" : 473,
        "y" : 844
      },
      "c" : {
        "x" : 466,
        "y" : 840
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 466,
        "y" : 840
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 428,
        "y" : 839
      },
      "b" : {
        "x" : 440,
        "y" : 851
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 434,
        "y" : 845
      }
    },
    "inputs" : [ {
      "id" : 91670
    } ],
    "outputs" : [ {
      "id" : 91672
    } ]
  }, {
    "id" : 91644,
    "reactomeId" : 10326004,
    "displayName" : "p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 740,
      "y" : 667
    },
    "minX" : 714,
    "maxX" : 798,
    "minY" : 661,
    "maxY" : 673,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 798,
        "y" : 669
      },
      "to" : {
        "x" : 740,
        "y" : 667
      }
    }, {
      "from" : {
        "x" : 740,
        "y" : 667
      },
      "to" : {
        "x" : 714,
        "y" : 668
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 721,
        "y" : 664
      },
      "b" : {
        "x" : 714,
        "y" : 668
      },
      "c" : {
        "x" : 721,
        "y" : 672
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 721,
        "y" : 672
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 734,
        "y" : 661
      },
      "b" : {
        "x" : 746,
        "y" : 673
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 740,
        "y" : 667
      }
    },
    "inputs" : [ {
      "id" : 91636
    } ],
    "outputs" : [ {
      "id" : 91645
    } ],
    "catalysts" : [ {
      "id" : 91642,
      "points" : [ {
        "x" : 737,
        "y" : 593
      } ]
    } ]
  }, {
    "id" : 91646,
    "reactomeId" : 10325997,
    "displayName" : "p-Y407-YAP1 translocates from the cytosol to the nucleoplasm",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 716,
      "y" : 725
    },
    "minX" : 678,
    "maxX" : 753,
    "minY" : 688,
    "maxY" : 756,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 678,
        "y" : 688
      },
      "to" : {
        "x" : 716,
        "y" : 725
      }
    }, {
      "from" : {
        "x" : 716,
        "y" : 725
      },
      "to" : {
        "x" : 753,
        "y" : 756
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 745,
        "y" : 755
      },
      "b" : {
        "x" : 753,
        "y" : 756
      },
      "c" : {
        "x" : 750,
        "y" : 748
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 750,
        "y" : 748
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 710,
        "y" : 719
      },
      "b" : {
        "x" : 722,
        "y" : 731
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 716,
        "y" : 725
      }
    },
    "inputs" : [ {
      "id" : 91645
    } ],
    "outputs" : [ {
      "id" : 91647
    } ]
  } ],
  "compartments" : [ {
    "id" : 91673,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 586,
      "y" : 461
    },
    "minX" : 19,
    "maxX" : 1154,
    "minY" : 0,
    "maxY" : 923,
    "prop" : {
      "x" : 19,
      "y" : 0,
      "width" : 1135,
      "height" : 923
    },
    "textPosition" : {
      "x" : 37,
      "y" : 878
    },
    "insets" : {
      "x" : 29,
      "y" : 10,
      "width" : 1115,
      "height" : 903
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 91674, 91618, 91619, 91620, 91617, 91621, 91622, 91623, 91624, 91625, 91626, 91627, 91628, 91629, 91631, 91632, 91643, 91638, 91633, 91634, 91635, 91636, 91637, 91639, 91640, 91641, 91642, 91644, 91645, 91648, 91649, 91650, 91651, 91652, 91653, 91654, 91655, 91656, 91657, 91658, 91659, 91662, 91663, 91661, 91660, 91664, 91667, 91668, 91666, 91665, 91669, 91670, 91646, 91630 ]
  }, {
    "id" : 91674,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 719,
      "y" : 813
    },
    "minX" : 425,
    "maxX" : 1013,
    "minY" : 727,
    "maxY" : 900,
    "prop" : {
      "x" : 425,
      "y" : 727,
      "width" : 588,
      "height" : 173
    },
    "textPosition" : {
      "x" : 442,
      "y" : 857
    },
    "insets" : {
      "x" : 435,
      "y" : 737,
      "width" : 568,
      "height" : 153
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 91647, 91672, 91671 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1278,
  "minY" : 0,
  "maxY" : 923,
  "disease" : false
}