{ "dbId" : 10331943, "stableId" : "R-CFA-9839373", "displayName" : "Signaling by TGFBR3", "nodes" : [ { "id" : 99649, "reactomeId" : 10329467, "displayName" : "Signaling by Activin", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 720, "y" : 871 }, "minX" : 622, "maxX" : 819, "minY" : 824, "maxY" : 918, "prop" : { "x" : 622, "y" : 824, "width" : 197, "height" : 94 }, "textPosition" : { "x" : 653, "y" : 856 }, "connectors" : [ ] }, { "id" : 99651, "reactomeId" : 10329463, "displayName" : "Signaling by TGF-beta Receptor Complex", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 749, "y" : 501 }, "minX" : 616, "maxX" : 882, "minY" : 444, "maxY" : 559, "prop" : { "x" : 616, "y" : 444, "width" : 266, "height" : 115 }, "textPosition" : { "x" : 641, "y" : 480 }, "connectors" : [ ] }, { "id" : 99650, "reactomeId" : 10329595, "displayName" : "Signaling by FGFR1", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 720, "y" : 1278 }, "minX" : 622, "maxX" : 818, "minY" : 1223, "maxY" : 1334, "prop" : { "x" : 622, "y" : 1223, "width" : 196, "height" : 111 }, "textPosition" : { "x" : 653, "y" : 1264 }, "connectors" : [ ] }, { "id" : 99652, "reactomeId" : 10329837, "displayName" : "Signaling by BMP", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 725, "y" : 1007 }, "minX" : 630, "maxX" : 821, "minY" : 969, "maxY" : 1046, "prop" : { "x" : 630, "y" : 969, "width" : 191, "height" : 77 }, "textPosition" : { "x" : 665, "y" : 993 }, "connectors" : [ ] }, { "id" : 99595, "reactomeId" : 10324579, "displayName" : "TGFBR3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2032, "y" : 1062 }, "minX" : 1970, "maxX" : 2101, "minY" : 1045, "maxY" : 1074, "prop" : { "x" : 1970, "y" : 1051, "width" : 125, "height" : 23 }, "textPosition" : { "x" : 2005, "y" : 1052 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2095, "y" : 1051 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2095, "y" : 1051 } } }, "connectors" : [ { "edgeId" : 99594, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99596, "reactomeId" : 10238958, "displayName" : "TGFBR3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2027, "y" : 232 }, "minX" : 1964, "maxX" : 2096, "minY" : 208, "maxY" : 251, "prop" : { "x" : 1964, "y" : 214, "width" : 126, "height" : 37 }, "textPosition" : { "x" : 1999, "y" : 222 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2090, "y" : 214 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2090, "y" : 214 } } }, "connectors" : [ { "edgeId" : 99594, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99597, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99599, "reactomeId" : 10324559, "displayName" : "TGFBR3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1460, "y" : 228 }, "minX" : 1395, "maxX" : 1531, "minY" : 75, "maxY" : 254, "prop" : { "x" : 1395, "y" : 203, "width" : 130, "height" : 51 }, "textPosition" : { "x" : 1432, "y" : 218 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1525, "y" : 203 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1525, "y" : 203 } } }, "connectors" : [ { "edgeId" : 99597, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1459, "y" : 200 }, "to" : { "x" : 1457, "y" : 75 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1455, "y" : 193 }, "b" : { "x" : 1459, "y" : 200 }, "c" : { "x" : 1463, "y" : 193 }, "type" : "ARROW", "centre" : { "x" : 1463, "y" : 193 } } }, { "edgeId" : 99603, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99598, "reactomeId" : 10239003, "displayName" : "TGFBR3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1076, "y" : 74 }, "minX" : 772, "maxX" : 1457, "minY" : 50, "maxY" : 93, "prop" : { "x" : 1012, "y" : 56, "width" : 128, "height" : 37 }, "textPosition" : { "x" : 1048, "y" : 64 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1140, "y" : 56 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1140, "y" : 56 } } }, "connectors" : [ { "edgeId" : 99597, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1143, "y" : 74 }, "to" : { "x" : 1457, "y" : 75 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1150, "y" : 70 }, "b" : { "x" : 1143, "y" : 74 }, "c" : { "x" : 1150, "y" : 78 }, "type" : "ARROW", "centre" : { "x" : 1150, "y" : 78 } } }, { "edgeId" : 99610, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1009, "y" : 75 }, "to" : { "x" : 772, "y" : 83 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99601, "reactomeId" : 10269590, "displayName" : "TIMP2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1464, "y" : 24 }, "minX" : 1400, "maxX" : 1540, "minY" : 0, "maxY" : 74, "prop" : { "x" : 1400, "y" : 6, "width" : 128, "height" : 37 }, "textPosition" : { "x" : 1442, "y" : 14 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1528, "y" : 6 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1528, "y" : 6 } } }, "connectors" : [ { "edgeId" : 99597, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1493, "y" : 46 }, "to" : { "x" : 1538, "y" : 71 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1536, "y" : 74 }, "b" : { "x" : 1540, "y" : 68 }, "c" : { "x" : 1538, "y" : 71 }, "type" : "STOP", "centre" : { "x" : 1538, "y" : 71 } } } ] }, { "id" : 99600, "reactomeId" : 10269872, "displayName" : "MMP14 (16)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1804, "y" : 86 }, "minX" : 1554, "maxX" : 1871, "minY" : 68, "maxY" : 105, "prop" : { "x" : 1737, "y" : 68, "width" : 134, "height" : 37 }, "textPosition" : { "x" : 1763, "y" : 76 }, "connectors" : [ { "edgeId" : 99597, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1731, "y" : 83 }, "to" : { "x" : 1562, "y" : 76 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1558, "y" : 76 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1558, "y" : 76 } } } ] }, { "id" : 99602, "reactomeId" : 10259424, "displayName" : "TIMP1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1592, "y" : 24 }, "minX" : 1528, "maxX" : 1662, "minY" : 0, "maxY" : 72, "prop" : { "x" : 1528, "y" : 6, "width" : 128, "height" : 37 }, "textPosition" : { "x" : 1570, "y" : 14 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1656, "y" : 6 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1656, "y" : 6 } } }, "connectors" : [ { "edgeId" : 99597, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1575, "y" : 46 }, "to" : { "x" : 1552, "y" : 69 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1549, "y" : 66 }, "b" : { "x" : 1555, "y" : 72 }, "c" : { "x" : 1552, "y" : 69 }, "type" : "STOP", "centre" : { "x" : 1552, "y" : 69 } } } ] }, { "id" : 99604, "reactomeId" : 10242588, "displayName" : "gamma-secretase complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1574, "y" : 388 }, "minX" : 1467, "maxX" : 1639, "minY" : 357, "maxY" : 414, "prop" : { "x" : 1515, "y" : 363, "width" : 118, "height" : 51 }, "textPosition" : { "x" : 1536, "y" : 365 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1633, "y" : 363 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1633, "y" : 363 } } }, "connectors" : [ { "edgeId" : 99603, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1512, "y" : 386 }, "to" : { "x" : 1475, "y" : 385 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1471, "y" : 385 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1471, "y" : 385 } } } ] }, { "id" : 99607, "reactomeId" : 10238958, "displayName" : "TGFBR3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 339, "y" : 250 }, "minX" : 276, "maxX" : 470, "minY" : 155, "maxY" : 269, "prop" : { "x" : 276, "y" : 232, "width" : 126, "height" : 37 }, "textPosition" : { "x" : 311, "y" : 240 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 402, "y" : 232 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 402, "y" : 232 } } }, "connectors" : [ { "edgeId" : 99605, "type" : "INPUT", "segments" : [ { "from" : { "x" : 364, "y" : 229 }, "to" : { "x" : 470, "y" : 155 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99606, "reactomeId" : 10238964, "displayName" : "TGFB1,TGFB2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 470, "y" : 85 }, "minX" : 406, "maxX" : 772, "minY" : 67, "maxY" : 155, "prop" : { "x" : 406, "y" : 67, "width" : 128, "height" : 37 }, "textPosition" : { "x" : 425, "y" : 75 }, "connectors" : [ { "edgeId" : 99605, "type" : "INPUT", "segments" : [ { "from" : { "x" : 470, "y" : 110 }, "to" : { "x" : 470, "y" : 155 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99610, "type" : "INPUT", "segments" : [ { "from" : { "x" : 540, "y" : 84 }, "to" : { "x" : 772, "y" : 83 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99609, "reactomeId" : 10239005, "displayName" : "TGFBR3(1-783):TGFB1,TGFB2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 584, "y" : 149 }, "minX" : 474, "maxX" : 647, "minY" : 125, "maxY" : 233, "prop" : { "x" : 528, "y" : 131, "width" : 113, "height" : 37 }, "textPosition" : { "x" : 532, "y" : 133 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 641, "y" : 131 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 641, "y" : 131 } } }, "connectors" : [ { "edgeId" : 99605, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 559, "y" : 171 }, "to" : { "x" : 476, "y" : 230 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 474, "y" : 227 }, "b" : { "x" : 478, "y" : 233 }, "c" : { "x" : 476, "y" : 230 }, "type" : "STOP", "centre" : { "x" : 476, "y" : 230 } } }, { "edgeId" : 99610, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99608, "reactomeId" : 10238966, "displayName" : "TGFB1,TGFB2:TGFBR3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 613, "y" : 232 }, "minX" : 550, "maxX" : 913, "minY" : 208, "maxY" : 302, "prop" : { "x" : 550, "y" : 214, "width" : 126, "height" : 37 }, "textPosition" : { "x" : 566, "y" : 216 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 676, "y" : 214 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 676, "y" : 214 } } }, "connectors" : [ { "edgeId" : 99622, "type" : "INPUT", "segments" : [ { "from" : { "x" : 674, "y" : 254 }, "to" : { "x" : 778, "y" : 282 } }, { "from" : { "x" : 778, "y" : 282 }, "to" : { "x" : 913, "y" : 237 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99605, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99611, "type" : "INPUT", "segments" : [ { "from" : { "x" : 606, "y" : 254 }, "to" : { "x" : 590, "y" : 302 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99613, "reactomeId" : 10238968, "displayName" : "TGFB1,TGFB2:TGFBR3:TGFBR2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 189, "y" : 353 }, "minX" : 132, "maxX" : 292, "minY" : 328, "maxY" : 418, "prop" : { "x" : 132, "y" : 334, "width" : 115, "height" : 39 }, "textPosition" : { "x" : 136, "y" : 338 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 247, "y" : 334 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 247, "y" : 334 } } }, "connectors" : [ { "edgeId" : 99611, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99614, "type" : "INPUT", "segments" : [ { "from" : { "x" : 250, "y" : 371 }, "to" : { "x" : 292, "y" : 387 } }, { "from" : { "x" : 292, "y" : 387 }, "to" : { "x" : 292, "y" : 418 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99612, "reactomeId" : 10238887, "displayName" : "TGFBR2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 777, "y" : 226 }, "minX" : 590, "maxX" : 838, "minY" : 202, "maxY" : 302, "prop" : { "x" : 723, "y" : 208, "width" : 109, "height" : 37 }, "textPosition" : { "x" : 750, "y" : 216 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 832, "y" : 208 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 832, "y" : 208 } } }, "connectors" : [ { "edgeId" : 99611, "type" : "INPUT", "segments" : [ { "from" : { "x" : 731, "y" : 248 }, "to" : { "x" : 590, "y" : 302 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99615, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 393, "y" : 418 }, "minX" : 292, "maxX" : 440, "minY" : 402, "maxY" : 434, "prop" : { "x" : 348, "y" : 403, "width" : 91, "height" : 31 }, "textPosition" : { "x" : 378, "y" : 408 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 434, "y" : 408 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 434, "y" : 408 } } }, "connectors" : [ { "edgeId" : 99614, "type" : "INPUT", "segments" : [ { "from" : { "x" : 345, "y" : 418 }, "to" : { "x" : 292, "y" : 418 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99617, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 386, "y" : 509 }, "minX" : 292, "maxX" : 433, "minY" : 477, "maxY" : 525, "prop" : { "x" : 340, "y" : 494, "width" : 92, "height" : 31 }, "textPosition" : { "x" : 369, "y" : 499 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 427, "y" : 499 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 427, "y" : 499 } } }, "connectors" : [ { "edgeId" : 99614, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 340, "y" : 491 }, "to" : { "x" : 292, "y" : 477 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 332, "y" : 493 }, "b" : { "x" : 340, "y" : 491 }, "c" : { "x" : 334, "y" : 485 }, "type" : "ARROW", "centre" : { "x" : 334, "y" : 485 } } } ] }, { "id" : 99616, "reactomeId" : 10324544, "displayName" : "TGFB1,TGFB2:pTGFBR3:TGFBR2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 202, "y" : 519 }, "minX" : 141, "maxX" : 292, "minY" : 477, "maxY" : 562, "prop" : { "x" : 141, "y" : 501, "width" : 123, "height" : 37 }, "textPosition" : { "x" : 145, "y" : 503 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 264, "y" : 501 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 264, "y" : 501 } } }, "connectors" : [ { "edgeId" : 99619, "type" : "INPUT", "segments" : [ { "from" : { "x" : 201, "y" : 541 }, "to" : { "x" : 201, "y" : 562 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99614, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 241, "y" : 498 }, "to" : { "x" : 292, "y" : 477 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 246, "y" : 492 }, "b" : { "x" : 241, "y" : 498 }, "c" : { "x" : 249, "y" : 499 }, "type" : "ARROW", "centre" : { "x" : 249, "y" : 499 } } } ] }, { "id" : 99618, "reactomeId" : 10238933, "displayName" : "TGFB1:TGFBR2:TGFBR1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 185, "y" : 421 }, "minX" : 122, "maxX" : 254, "minY" : 389, "maxY" : 472, "prop" : { "x" : 122, "y" : 395, "width" : 126, "height" : 52 }, "textPosition" : { "x" : 134, "y" : 412 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 248, "y" : 395 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 248, "y" : 395 } } }, "connectors" : [ { "edgeId" : 99614, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 186, "y" : 450 }, "to" : { "x" : 187, "y" : 464 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 187, "y" : 468 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 187, "y" : 468 } } } ] }, { "id" : 99621, "reactomeId" : 10324546, "displayName" : "pTGFBR3-complex:ARRB", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 205, "y" : 633 }, "minX" : 144, "maxX" : 273, "minY" : 607, "maxY" : 654, "prop" : { "x" : 144, "y" : 613, "width" : 123, "height" : 41 }, "textPosition" : { "x" : 144, "y" : 619 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 267, "y" : 613 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 267, "y" : 613 } } }, "connectors" : [ { "edgeId" : 99619, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99625, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99620, "reactomeId" : 10290684, "displayName" : "ARRB", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 389, "y" : 562 }, "minX" : 201, "maxX" : 435, "minY" : 551, "maxY" : 574, "prop" : { "x" : 344, "y" : 551, "width" : 91, "height" : 23 }, "textPosition" : { "x" : 369, "y" : 552 }, "connectors" : [ { "edgeId" : 99619, "type" : "INPUT", "segments" : [ { "from" : { "x" : 338, "y" : 562 }, "to" : { "x" : 201, "y" : 562 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99623, "reactomeId" : 10241520, "displayName" : "GIPC1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 916, "y" : 347 }, "minX" : 894, "maxX" : 944, "minY" : 237, "maxY" : 359, "prop" : { "x" : 894, "y" : 336, "width" : 44, "height" : 23 }, "textPosition" : { "x" : 894, "y" : 337 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 938, "y" : 336 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 938, "y" : 336 } } }, "connectors" : [ { "edgeId" : 99622, "type" : "INPUT", "segments" : [ { "from" : { "x" : 915, "y" : 333 }, "to" : { "x" : 913, "y" : 237 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99624, "reactomeId" : 10324585, "displayName" : "TGFB1,TGFB2:TGFBR3:GIPC1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1007, "y" : 242 }, "minX" : 946, "maxX" : 1155, "minY" : 204, "maxY" : 431, "prop" : { "x" : 946, "y" : 210, "width" : 123, "height" : 65 }, "textPosition" : { "x" : 960, "y" : 240 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1069, "y" : 210 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1069, "y" : 210 } } }, "connectors" : [ { "edgeId" : 99622, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99627, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1032, "y" : 278 }, "to" : { "x" : 1152, "y" : 429 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1149, "y" : 431 }, "b" : { "x" : 1155, "y" : 427 }, "c" : { "x" : 1152, "y" : 429 }, "type" : "STOP", "centre" : { "x" : 1152, "y" : 429 } } } ] }, { "id" : 99626, "reactomeId" : 10324552, "displayName" : "pTGFBR3-complex:ARBB_endo", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 754, "y" : 710 }, "minX" : 693, "maxX" : 822, "minY" : 672, "maxY" : 743, "prop" : { "x" : 693, "y" : 678, "width" : 123, "height" : 65 }, "textPosition" : { "x" : 693, "y" : 708 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 816, "y" : 678 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 816, "y" : 678 } } }, "connectors" : [ { "edgeId" : 99625, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99628, "reactomeId" : 10238958, "displayName" : "TGFBR3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1159, "y" : 229 }, "minX" : 1096, "maxX" : 1228, "minY" : 205, "maxY" : 248, "prop" : { "x" : 1096, "y" : 211, "width" : 126, "height" : 37 }, "textPosition" : { "x" : 1131, "y" : 219 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1222, "y" : 211 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1222, "y" : 211 } } }, "connectors" : [ { "edgeId" : 99627, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99631, "reactomeId" : 10238958, "displayName" : "TGFBR3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 203, "y" : 698 }, "minX" : 140, "maxX" : 272, "minY" : 674, "maxY" : 751, "prop" : { "x" : 140, "y" : 680, "width" : 126, "height" : 37 }, "textPosition" : { "x" : 175, "y" : 688 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 266, "y" : 680 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 266, "y" : 680 } } }, "connectors" : [ { "edgeId" : 99629, "type" : "INPUT", "segments" : [ { "from" : { "x" : 202, "y" : 720 }, "to" : { "x" : 202, "y" : 751 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99630, "reactomeId" : 10244566, "displayName" : "INHIBIN-A", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 67, "y" : 753 }, "minX" : 34, "maxX" : 202, "minY" : 736, "maxY" : 765, "prop" : { "x" : 34, "y" : 742, "width" : 67, "height" : 23 }, "textPosition" : { "x" : 35, "y" : 744 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 101, "y" : 742 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 101, "y" : 742 } } }, "connectors" : [ { "edgeId" : 99629, "type" : "INPUT", "segments" : [ { "from" : { "x" : 104, "y" : 752 }, "to" : { "x" : 202, "y" : 751 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99632, "reactomeId" : 10244568, "displayName" : "INHIBIN-A:TGFBR3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 205, "y" : 811 }, "minX" : 153, "maxX" : 293, "minY" : 788, "maxY" : 861, "prop" : { "x" : 153, "y" : 794, "width" : 105, "height" : 35 }, "textPosition" : { "x" : 171, "y" : 794 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 258, "y" : 794 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 258, "y" : 794 } } }, "connectors" : [ { "edgeId" : 99629, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99633, "type" : "INPUT", "segments" : [ { "from" : { "x" : 235, "y" : 832 }, "to" : { "x" : 293, "y" : 861 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99635, "reactomeId" : 10244570, "displayName" : "INHIBIN-A:TGFBR3:ACVR2A", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 204, "y" : 1011 }, "minX" : 150, "maxX" : 265, "minY" : 987, "maxY" : 1030, "prop" : { "x" : 150, "y" : 993, "width" : 109, "height" : 37 }, "textPosition" : { "x" : 151, "y" : 995 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 259, "y" : 993 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 259, "y" : 993 } } }, "connectors" : [ { "edgeId" : 99633, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99634, "reactomeId" : 10244495, "displayName" : "ACVR2A", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 195, "y" : 875 }, "minX" : 140, "maxX" : 293, "minY" : 851, "maxY" : 894, "prop" : { "x" : 140, "y" : 857, "width" : 111, "height" : 37 }, "textPosition" : { "x" : 167, "y" : 865 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 251, "y" : 857 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 251, "y" : 857 } } }, "connectors" : [ { "edgeId" : 99633, "type" : "INPUT", "segments" : [ { "from" : { "x" : 254, "y" : 867 }, "to" : { "x" : 293, "y" : 861 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99637, "reactomeId" : 10233152, "displayName" : "FGF2(143-288)", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 64, "y" : 1133 }, "minX" : 0, "maxX" : 194, "minY" : 1109, "maxY" : 1152, "prop" : { "x" : 0, "y" : 1115, "width" : 128, "height" : 37 }, "textPosition" : { "x" : 13, "y" : 1123 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 128, "y" : 1115 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 128, "y" : 1115 } } }, "connectors" : [ { "edgeId" : 99636, "type" : "INPUT", "segments" : [ { "from" : { "x" : 131, "y" : 1133 }, "to" : { "x" : 194, "y" : 1133 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99639, "reactomeId" : 10241516, "displayName" : "FGF2:TGFBR3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 196, "y" : 1219 }, "minX" : 152, "maxX" : 246, "minY" : 1202, "maxY" : 1291, "prop" : { "x" : 152, "y" : 1208, "width" : 88, "height" : 23 }, "textPosition" : { "x" : 168, "y" : 1196 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 240, "y" : 1208 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 240, "y" : 1208 } } }, "connectors" : [ { "edgeId" : 99636, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99640, "type" : "INPUT", "segments" : [ { "from" : { "x" : 196, "y" : 1234 }, "to" : { "x" : 197, "y" : 1291 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99638, "reactomeId" : 10238958, "displayName" : "TGFBR3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 194, "y" : 1078 }, "minX" : 131, "maxX" : 263, "minY" : 1054, "maxY" : 1133, "prop" : { "x" : 131, "y" : 1060, "width" : 126, "height" : 37 }, "textPosition" : { "x" : 166, "y" : 1068 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 257, "y" : 1060 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 257, "y" : 1060 } } }, "connectors" : [ { "edgeId" : 99636, "type" : "INPUT", "segments" : [ { "from" : { "x" : 194, "y" : 1100 }, "to" : { "x" : 194, "y" : 1133 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99641, "reactomeId" : 10241520, "displayName" : "GIPC1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 299, "y" : 1219 }, "minX" : 197, "maxX" : 327, "minY" : 1202, "maxY" : 1291, "prop" : { "x" : 277, "y" : 1208, "width" : 44, "height" : 23 }, "textPosition" : { "x" : 277, "y" : 1209 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 321, "y" : 1208 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 321, "y" : 1208 } } }, "connectors" : [ { "edgeId" : 99640, "type" : "INPUT", "segments" : [ { "from" : { "x" : 282, "y" : 1234 }, "to" : { "x" : 197, "y" : 1291 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99642, "reactomeId" : 10241522, "displayName" : "FGF2:TGFBR3:GIPC1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 447, "y" : 1284 }, "minX" : 384, "maxX" : 517, "minY" : 1267, "maxY" : 1296, "prop" : { "x" : 384, "y" : 1273, "width" : 127, "height" : 23 }, "textPosition" : { "x" : 400, "y" : 1261 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 511, "y" : 1273 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 511, "y" : 1273 } } }, "connectors" : [ { "edgeId" : 99640, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 99619, "reactomeId" : 10324571, "displayName" : "TGFBR3 binding to ARRB1/2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 202, "y" : 586 }, "minX" : 195, "maxX" : 207, "minY" : 556, "maxY" : 610, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 201, "y" : 562 }, "to" : { "x" : 202, "y" : 586 } }, { "from" : { "x" : 202, "y" : 586 }, "to" : { "x" : 203, "y" : 610 } } ], "endShape" : { "a" : { "x" : 199, "y" : 603 }, "b" : { "x" : 203, "y" : 610 }, "c" : { "x" : 207, "y" : 603 }, "type" : "ARROW", "centre" : { "x" : 207, "y" : 603 } }, "reactionShape" : { "c" : { "x" : 202, "y" : 586 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 202, "y" : 586 } }, "inputs" : [ { "id" : 99620, "points" : [ { "x" : 338, "y" : 562 } ] }, { "id" : 99616, "points" : [ { "x" : 201, "y" : 541 } ] } ], "outputs" : [ { "id" : 99621 } ] }, { "id" : 99622, "reactomeId" : 10324590, "displayName" : "TGFBR3 binding to GIPC1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 928, "y" : 237 }, "minX" : 907, "maxX" : 943, "minY" : 231, "maxY" : 243, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 913, "y" : 237 }, "to" : { "x" : 928, "y" : 237 } }, { "from" : { "x" : 928, "y" : 237 }, "to" : { "x" : 943, "y" : 238 } } ], "endShape" : { "a" : { "x" : 936, "y" : 242 }, "b" : { "x" : 943, "y" : 238 }, "c" : { "x" : 936, "y" : 234 }, "type" : "ARROW", "centre" : { "x" : 936, "y" : 234 } }, "reactionShape" : { "c" : { "x" : 928, "y" : 237 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 928, "y" : 237 } }, "inputs" : [ { "id" : 99608, "points" : [ { "x" : 674, "y" : 254 }, { "x" : 778, "y" : 282 } ] }, { "id" : 99623, "points" : [ { "x" : 915, "y" : 333 } ] } ], "outputs" : [ { "id" : 99624 } ] }, { "id" : 99625, "reactomeId" : 10324554, "displayName" : "Endocytosis of TGFBR3:ARRB complex", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 519, "y" : 634 }, "minX" : 270, "maxX" : 690, "minY" : 628, "maxY" : 690, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 270, "y" : 633 }, "to" : { "x" : 519, "y" : 634 } }, { "from" : { "x" : 519, "y" : 634 }, "to" : { "x" : 690, "y" : 690 } } ], "endShape" : { "a" : { "x" : 682, "y" : 692 }, "b" : { "x" : 690, "y" : 690 }, "c" : { "x" : 685, "y" : 684 }, "type" : "ARROW", "centre" : { "x" : 685, "y" : 684 } }, "reactionShape" : { "a" : { "x" : 513, "y" : 628 }, "b" : { "x" : 525, "y" : 640 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 519, "y" : 634 } }, "inputs" : [ { "id" : 99621 } ], "outputs" : [ { "id" : 99626 } ] }, { "id" : 99627, "reactomeId" : 10324587, "displayName" : "TGFBR3 degradation", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1158, "y" : 436 }, "minX" : 1152, "maxX" : 1236, "minY" : 251, "maxY" : 442, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1158, "y" : 251 }, "to" : { "x" : 1158, "y" : 436 } }, { "from" : { "x" : 1158, "y" : 436 }, "to" : { "x" : 1236, "y" : 437 } } ], "reactionShape" : { "a" : { "x" : 1152, "y" : 430 }, "b" : { "x" : 1164, "y" : 442 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1158, "y" : 436 } }, "inputs" : [ { "id" : 99628 } ], "inhibitors" : [ { "id" : 99624, "points" : [ { "x" : 1032, "y" : 278 } ] } ] }, { "id" : 99594, "reactomeId" : 10324581, "displayName" : "TGFBR3 translocation to plasma membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2029, "y" : 739 }, "minX" : 2023, "maxX" : 2035, "minY" : 254, "maxY" : 1048, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2031, "y" : 1048 }, "to" : { "x" : 2029, "y" : 739 } }, { "from" : { "x" : 2029, "y" : 739 }, "to" : { "x" : 2027, "y" : 254 } } ], "endShape" : { "a" : { "x" : 2031, "y" : 261 }, "b" : { "x" : 2027, "y" : 254 }, "c" : { "x" : 2023, "y" : 261 }, "type" : "ARROW", "centre" : { "x" : 2023, "y" : 261 } }, "reactionShape" : { "a" : { "x" : 2023, "y" : 733 }, "b" : { "x" : 2035, "y" : 745 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2029, "y" : 739 } }, "inputs" : [ { "id" : 99595 } ], "outputs" : [ { "id" : 99596 } ] }, { "id" : 99597, "reactomeId" : 10324561, "displayName" : "TGFBR3_mem cleavage by MMPs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1546, "y" : 75 }, "minX" : 1457, "maxX" : 1970, "minY" : 69, "maxY" : 211, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1970, "y" : 211 }, "to" : { "x" : 1546, "y" : 75 } }, { "from" : { "x" : 1546, "y" : 75 }, "to" : { "x" : 1457, "y" : 75 } } ], "reactionShape" : { "a" : { "x" : 1540, "y" : 69 }, "b" : { "x" : 1552, "y" : 81 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1546, "y" : 75 } }, "inputs" : [ { "id" : 99596 } ], "outputs" : [ { "id" : 99598, "points" : [ { "x" : 1143, "y" : 74 } ] }, { "id" : 99599, "points" : [ { "x" : 1459, "y" : 200 } ] } ], "catalysts" : [ { "id" : 99600, "points" : [ { "x" : 1731, "y" : 83 } ] } ], "inhibitors" : [ { "id" : 99601, "points" : [ { "x" : 1493, "y" : 46 } ] }, { "id" : 99602, "points" : [ { "x" : 1575, "y" : 46 } ] } ] }, { "id" : 99629, "reactomeId" : 10324577, "displayName" : "Inhibin-A binding to TGFBR3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 203, "y" : 771 }, "minX" : 198, "maxX" : 210, "minY" : 751, "maxY" : 797, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 202, "y" : 751 }, "to" : { "x" : 203, "y" : 771 } }, { "from" : { "x" : 203, "y" : 771 }, "to" : { "x" : 204, "y" : 791 } } ], "endShape" : { "a" : { "x" : 200, "y" : 784 }, "b" : { "x" : 204, "y" : 791 }, "c" : { "x" : 208, "y" : 784 }, "type" : "ARROW", "centre" : { "x" : 208, "y" : 784 } }, "reactionShape" : { "c" : { "x" : 203, "y" : 771 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 203, "y" : 771 } }, "inputs" : [ { "id" : 99630, "points" : [ { "x" : 104, "y" : 752 } ] }, { "id" : 99631, "points" : [ { "x" : 202, "y" : 720 } ] } ], "outputs" : [ { "id" : 99632 } ] }, { "id" : 99633, "reactomeId" : 10324592, "displayName" : "InhibinA-TGFBR3 binding to ACVR2A", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 205, "y" : 937 }, "minX" : 199, "maxX" : 293, "minY" : 861, "maxY" : 990, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 293, "y" : 861 }, "to" : { "x" : 205, "y" : 937 } }, { "from" : { "x" : 205, "y" : 937 }, "to" : { "x" : 204, "y" : 990 } } ], "endShape" : { "a" : { "x" : 200, "y" : 983 }, "b" : { "x" : 204, "y" : 990 }, "c" : { "x" : 208, "y" : 983 }, "type" : "ARROW", "centre" : { "x" : 208, "y" : 983 } }, "reactionShape" : { "c" : { "x" : 205, "y" : 937 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 205, "y" : 937 } }, "inputs" : [ { "id" : 99634, "points" : [ { "x" : 254, "y" : 867 } ] }, { "id" : 99632, "points" : [ { "x" : 235, "y" : 832 } ] } ], "outputs" : [ { "id" : 99635 } ] }, { "id" : 99603, "reactomeId" : 10324567, "displayName" : "TGFBR3(784-851) degradation", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1459, "y" : 385 }, "minX" : 1453, "maxX" : 1465, "minY" : 257, "maxY" : 436, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1459, "y" : 257 }, "to" : { "x" : 1459, "y" : 385 } }, { "from" : { "x" : 1459, "y" : 385 }, "to" : { "x" : 1458, "y" : 436 } } ], "reactionShape" : { "a" : { "x" : 1453, "y" : 379 }, "b" : { "x" : 1465, "y" : 391 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1459, "y" : 385 } }, "inputs" : [ { "id" : 99599 } ], "catalysts" : [ { "id" : 99604, "points" : [ { "x" : 1512, "y" : 386 } ] } ] }, { "id" : 99605, "reactomeId" : 10324569, "displayName" : "TGFB1,TGFB2 bind TGFBR3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 469, "y" : 235 }, "minX" : 463, "maxX" : 547, "minY" : 155, "maxY" : 241, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 470, "y" : 155 }, "to" : { "x" : 469, "y" : 235 } }, { "from" : { "x" : 469, "y" : 235 }, "to" : { "x" : 547, "y" : 233 } } ], "endShape" : { "a" : { "x" : 540, "y" : 237 }, "b" : { "x" : 547, "y" : 233 }, "c" : { "x" : 540, "y" : 229 }, "type" : "ARROW", "centre" : { "x" : 540, "y" : 229 } }, "reactionShape" : { "c" : { "x" : 469, "y" : 235 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 469, "y" : 235 } }, "inputs" : [ { "id" : 99606, "points" : [ { "x" : 470, "y" : 110 } ] }, { "id" : 99607, "points" : [ { "x" : 364, "y" : 229 } ] } ], "outputs" : [ { "id" : 99608 } ], "inhibitors" : [ { "id" : 99609, "points" : [ { "x" : 559, "y" : 171 } ] } ] }, { "id" : 99636, "reactomeId" : 10324573, "displayName" : "TGFBR3 binding to FGF2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 195, "y" : 1135 }, "minX" : 189, "maxX" : 201, "minY" : 1129, "maxY" : 1205, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 194, "y" : 1133 }, "to" : { "x" : 195, "y" : 1135 } }, { "from" : { "x" : 195, "y" : 1135 }, "to" : { "x" : 195, "y" : 1205 } } ], "endShape" : { "a" : { "x" : 191, "y" : 1198 }, "b" : { "x" : 195, "y" : 1205 }, "c" : { "x" : 199, "y" : 1198 }, "type" : "ARROW", "centre" : { "x" : 199, "y" : 1198 } }, "reactionShape" : { "c" : { "x" : 195, "y" : 1135 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 195, "y" : 1135 } }, "inputs" : [ { "id" : 99637, "points" : [ { "x" : 131, "y" : 1133 } ] }, { "id" : 99638, "points" : [ { "x" : 194, "y" : 1100 } ] } ], "outputs" : [ { "id" : 99639 } ] }, { "id" : 99640, "reactomeId" : 10324575, "displayName" : "FGF2:TGFBR3 binding to GIPC1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 197, "y" : 1291 }, "minX" : 191, "maxX" : 381, "minY" : 1285, "maxY" : 1297, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 197, "y" : 1291 }, "to" : { "x" : 203, "y" : 1291 } }, { "from" : { "x" : 203, "y" : 1291 }, "to" : { "x" : 381, "y" : 1285 } } ], "endShape" : { "a" : { "x" : 374, "y" : 1289 }, "b" : { "x" : 381, "y" : 1285 }, "c" : { "x" : 374, "y" : 1281 }, "type" : "ARROW", "centre" : { "x" : 374, "y" : 1281 } }, "reactionShape" : { "c" : { "x" : 197, "y" : 1291 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 197, "y" : 1291 } }, "inputs" : [ { "id" : 99639, "points" : [ { "x" : 196, "y" : 1234 } ] }, { "id" : 99641, "points" : [ { "x" : 282, "y" : 1234 } ] } ], "outputs" : [ { "id" : 99642 } ] }, { "id" : 99611, "reactomeId" : 10324583, "displayName" : "TGFBR3 complex binds to TGFBR2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 186, "y" : 300 }, "minX" : 180, "maxX" : 590, "minY" : 294, "maxY" : 331, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 590, "y" : 302 }, "to" : { "x" : 186, "y" : 300 } }, { "from" : { "x" : 186, "y" : 300 }, "to" : { "x" : 187, "y" : 331 } } ], "endShape" : { "a" : { "x" : 183, "y" : 324 }, "b" : { "x" : 187, "y" : 331 }, "c" : { "x" : 191, "y" : 324 }, "type" : "ARROW", "centre" : { "x" : 191, "y" : 324 } }, "reactionShape" : { "c" : { "x" : 186, "y" : 300 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 186, "y" : 300 } }, "inputs" : [ { "id" : 99612, "points" : [ { "x" : 731, "y" : 248 } ] }, { "id" : 99608, "points" : [ { "x" : 606, "y" : 254 } ] } ], "outputs" : [ { "id" : 99613 } ] }, { "id" : 99610, "reactomeId" : 10324565, "displayName" : "TGFBR3(1-783) binds to TGFB1,TGFB2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 704, "y" : 105 }, "minX" : 630, "maxX" : 772, "minY" : 83, "maxY" : 134, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 772, "y" : 83 }, "to" : { "x" : 704, "y" : 105 } }, { "from" : { "x" : 704, "y" : 105 }, "to" : { "x" : 636, "y" : 128 } } ], "endShape" : { "a" : { "x" : 641, "y" : 122 }, "b" : { "x" : 636, "y" : 128 }, "c" : { "x" : 644, "y" : 130 }, "type" : "ARROW", "centre" : { "x" : 644, "y" : 130 } }, "reactionShape" : { "c" : { "x" : 704, "y" : 105 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 704, "y" : 105 } }, "inputs" : [ { "id" : 99598, "points" : [ { "x" : 1009, "y" : 75 } ] }, { "id" : 99606, "points" : [ { "x" : 540, "y" : 84 } ] } ], "outputs" : [ { "id" : 99609 } ] }, { "id" : 99614, "reactomeId" : 10324557, "displayName" : "TGFBR3 phosphorylation by TGFBR2 complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 188, "y" : 480 }, "minX" : 182, "maxX" : 294, "minY" : 418, "maxY" : 486, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 292, "y" : 418 }, "to" : { "x" : 294, "y" : 452 } }, { "from" : { "x" : 294, "y" : 452 }, "to" : { "x" : 188, "y" : 480 } }, { "from" : { "x" : 188, "y" : 480 }, "to" : { "x" : 292, "y" : 477 } } ], "reactionShape" : { "a" : { "x" : 182, "y" : 474 }, "b" : { "x" : 194, "y" : 486 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 188, "y" : 480 } }, "inputs" : [ { "id" : 99613, "points" : [ { "x" : 250, "y" : 371 }, { "x" : 292, "y" : 387 } ] }, { "id" : 99615, "points" : [ { "x" : 345, "y" : 418 } ] } ], "outputs" : [ { "id" : 99616, "points" : [ { "x" : 241, "y" : 498 } ] }, { "id" : 99617, "points" : [ { "x" : 340, "y" : 491 } ] } ], "catalysts" : [ { "id" : 99618, "points" : [ { "x" : 186, "y" : 450 } ] } ] } ], "compartments" : [ { "id" : 99653, "reactomeId" : 24337, "displayName" : "endocytic vesicle membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 775, "y" : 647 }, "minX" : 645, "maxX" : 905, "minY" : 590, "maxY" : 704, "prop" : { "x" : 645, "y" : 590, "width" : 260, "height" : 114 }, "textPosition" : { "x" : 683, "y" : 630 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 99626 ] }, { "id" : 99643, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1220, "y" : 1039 }, "minX" : 899, "maxX" : 1542, "minY" : 753, "maxY" : 1325, "prop" : { "x" : 899, "y" : 753, "width" : 643, "height" : 572 }, "textPosition" : { "x" : 917, "y" : 772 }, "insets" : { "x" : 909, "y" : 763, "width" : 623, "height" : 552 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 99644, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1149, "y" : 797 }, "minX" : 166, "maxX" : 2133, "minY" : 208, "maxY" : 1386, "prop" : { "x" : 166, "y" : 208, "width" : 1967, "height" : 1178 }, "textPosition" : { "x" : 222, "y" : 261 }, "insets" : { "x" : 176, "y" : 218, "width" : 1947, "height" : 1158 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 99643, 99595, 99594, 99596, 99599, 99604, 99608, 99607, 99612, 99613, 99611, 99617, 99618, 99615, 99614, 99616, 99620, 99621, 99624, 99622, 99623, 99628, 99627, 99631, 99632, 99629, 99633, 99634, 99635, 99639, 99638, 99636, 99642, 99641, 99657, 99650, 99658, 99651, 99659, 99652, 99660, 99605, 99619, 99603, 99640, 99653, 99625, 99649 ] } ], "notes" : [ ], "links" : [ { "id" : 99657, "renderableClass" : "Interaction", "position" : { "x" : 340, "y" : 871 }, "minX" : 221, "maxX" : 619, "minY" : 865, "maxY" : 990, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 221, "y" : 990 }, "to" : { "x" : 340, "y" : 871 } }, { "from" : { "x" : 340, "y" : 871 }, "to" : { "x" : 619, "y" : 871 } } ], "endShape" : { "a" : { "x" : 612, "y" : 875 }, "b" : { "x" : 619, "y" : 871 }, "c" : { "x" : 612, "y" : 867 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 612, "y" : 867 } }, "reactionShape" : { "a" : { "x" : 334, "y" : 865 }, "b" : { "x" : 346, "y" : 877 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 340, "y" : 871 } }, "inputs" : [ { "id" : 99635 } ], "outputs" : [ { "id" : 99649 } ] }, { "id" : 99659, "renderableClass" : "Interaction", "position" : { "x" : 534, "y" : 423 }, "minX" : 250, "maxX" : 613, "minY" : 352, "maxY" : 496, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 250, "y" : 352 }, "to" : { "x" : 534, "y" : 352 } }, { "from" : { "x" : 534, "y" : 352 }, "to" : { "x" : 534, "y" : 494 } }, { "from" : { "x" : 534, "y" : 494 }, "to" : { "x" : 613, "y" : 496 } } ], "endShape" : { "a" : { "x" : 606, "y" : 500 }, "b" : { "x" : 613, "y" : 496 }, "c" : { "x" : 606, "y" : 492 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 606, "y" : 492 } }, "reactionShape" : { "a" : { "x" : 528, "y" : 417 }, "b" : { "x" : 540, "y" : 429 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 534, "y" : 423 } }, "inputs" : [ { "id" : 99613 } ], "outputs" : [ { "id" : 99651 } ] }, { "id" : 99658, "renderableClass" : "Interaction", "position" : { "x" : 566, "y" : 1280 }, "minX" : 514, "maxX" : 619, "minY" : 1274, "maxY" : 1286, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 514, "y" : 1282 }, "to" : { "x" : 619, "y" : 1279 } } ], "endShape" : { "a" : { "x" : 612, "y" : 1283 }, "b" : { "x" : 619, "y" : 1279 }, "c" : { "x" : 612, "y" : 1275 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 612, "y" : 1275 } }, "reactionShape" : { "a" : { "x" : 560, "y" : 1274 }, "b" : { "x" : 572, "y" : 1286 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 566, "y" : 1280 } }, "inputs" : [ { "id" : 99642 } ], "outputs" : [ { "id" : 99650 } ] }, { "id" : 99661, "renderableClass" : "Interaction", "position" : { "x" : 76, "y" : 595 }, "minX" : 70, "maxX" : 644, "minY" : 433, "maxY" : 601, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 644, "y" : 562 }, "to" : { "x" : 580, "y" : 594 } }, { "from" : { "x" : 580, "y" : 594 }, "to" : { "x" : 76, "y" : 595 } }, { "from" : { "x" : 76, "y" : 595 }, "to" : { "x" : 78, "y" : 443 } }, { "from" : { "x" : 78, "y" : 443 }, "to" : { "x" : 119, "y" : 433 } } ], "endShape" : { "a" : { "x" : 113, "y" : 439 }, "b" : { "x" : 119, "y" : 433 }, "c" : { "x" : 111, "y" : 431 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 111, "y" : 431 } }, "reactionShape" : { "a" : { "x" : 70, "y" : 589 }, "b" : { "x" : 82, "y" : 601 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 76, "y" : 595 } }, "inputs" : [ { "id" : 99651 } ], "outputs" : [ { "id" : 99618 } ] }, { "id" : 99660, "renderableClass" : "Interaction", "position" : { "x" : 444, "y" : 1008 }, "minX" : 262, "maxX" : 627, "minY" : 1002, "maxY" : 1014, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 262, "y" : 1010 }, "to" : { "x" : 627, "y" : 1007 } } ], "endShape" : { "a" : { "x" : 620, "y" : 1011 }, "b" : { "x" : 627, "y" : 1007 }, "c" : { "x" : 620, "y" : 1003 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 620, "y" : 1003 } }, "reactionShape" : { "a" : { "x" : 438, "y" : 1002 }, "b" : { "x" : 450, "y" : 1014 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 444, "y" : 1008 } }, "inputs" : [ { "id" : 99635 } ], "outputs" : [ { "id" : 99652 } ] } ], "shadows" : [ { "id" : 99665, "reactomeId" : 10331949, "displayName" : "TGFBR3 regulates activin signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 163, "y" : 855 }, "minX" : 24, "maxX" : 303, "minY" : 670, "maxY" : 1040, "prop" : { "x" : 24, "y" : 753, "width" : 279, "height" : 287 }, "points" : [ { "x" : 24, "y" : 670 }, { "x" : 303, "y" : 670 }, { "x" : 303, "y" : 1040 }, { "x" : 24, "y" : 1040 } ], "colour" : "#666666" }, { "id" : 99664, "reactomeId" : 10331947, "displayName" : "TGFBR3 regulates FGF2 signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 255, "y" : 1178 }, "minX" : -10, "maxX" : 521, "minY" : 1050, "maxY" : 1307, "prop" : { "x" : -10, "y" : 1050, "width" : 531, "height" : 257 }, "points" : [ { "x" : -10, "y" : 1050 }, { "x" : 521, "y" : 1050 }, { "x" : 521, "y" : 1307 }, { "x" : -10, "y" : 1307 } ], "colour" : "#008000" }, { "id" : 99663, "reactomeId" : 10331945, "displayName" : "TGFBR3 PTM regulation", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1553, "y" : 540 }, "minX" : 1002, "maxX" : 2105, "minY" : -4, "maxY" : 1084, "prop" : { "x" : 1246, "y" : 46, "width" : 859, "height" : 707 }, "points" : [ { "x" : 1002, "y" : -4 }, { "x" : 2105, "y" : -4 }, { "x" : 2105, "y" : 1084 }, { "x" : 1002, "y" : 1084 } ], "colour" : "#dc3912" }, { "id" : 99662, "reactomeId" : 10331941, "displayName" : "TGFBR3 regulates TGF-beta signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 679, "y" : 399 }, "minX" : 112, "maxX" : 1246, "minY" : 46, "maxY" : 753, "prop" : { "x" : 112, "y" : 46, "width" : 890, "height" : 624 }, "points" : [ { "x" : 112, "y" : 46 }, { "x" : 1246, "y" : 46 }, { "x" : 1246, "y" : 753 }, { "x" : 112, "y" : 753 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 2133, "minY" : 0, "maxY" : 1386, "disease" : false }