{
  "dbId" : 10331787,
  "stId" : "R-CFA-9614085",
  "speciesName" : "Canis familiaris",
  "nodes" : [ {
    "dbId" : 427523,
    "stId" : "R-ALL-427523",
    "displayName" : "NAD+ [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90800 ],
    "identifier" : "57540",
    "standardIdentifier" : "chebi:57540",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10331793,
    "stId" : "R-CFA-9615017",
    "displayName" : "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes",
    "schemaClass" : "Pathway",
    "speciesId" : 49646,
    "diagramIds" : [ 90820 ]
  }, {
    "dbId" : 10231376,
    "stId" : "R-CFA-206099",
    "displayName" : "YWHAZ [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3Q4Y8",
    "standardIdentifier" : "uniprot:A0A8I3Q4Y8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "YWHAZ" ],
    "parents" : [ 10231378 ],
    "children" : [ ]
  }, {
    "dbId" : 10331795,
    "stId" : "R-CFA-9617828",
    "displayName" : "FOXO-mediated transcription of cell cycle genes",
    "schemaClass" : "Pathway",
    "speciesId" : 49646,
    "diagramIds" : [ 90821 ]
  }, {
    "dbId" : 10231378,
    "stId" : "R-CFA-206751",
    "displayName" : "YWHAZ dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90790 ],
    "parents" : [ 10318458, 10318448 ],
    "children" : [ 10231376 ]
  }, {
    "dbId" : 10247378,
    "stId" : "R-CFA-211158",
    "displayName" : "phospho-FOXO1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 90781 ],
    "identifier" : "A0A8I3PLD0",
    "standardIdentifier" : "uniprot:A0A8I3PLD0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO1" ],
    "parents" : [ 10318450, 10318444 ],
    "children" : [ ]
  }, {
    "dbId" : 10231372,
    "stId" : "R-CFA-2262714",
    "displayName" : "YWHAQ dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10318448 ],
    "children" : [ 10231370 ]
  }, {
    "dbId" : 10243981,
    "stId" : "R-CFA-199314",
    "displayName" : "phospho-FOXO4 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NW63",
    "standardIdentifier" : "uniprot:A0A8I3NW63",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO4" ],
    "parents" : [ 10318438 ],
    "children" : [ ]
  }, {
    "dbId" : 10318604,
    "stId" : "R-CFA-9622879",
    "displayName" : "SIRT3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3Q499",
    "standardIdentifier" : "uniprot:A0A8I3Q499",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10318606 ],
    "children" : [ ]
  }, {
    "dbId" : 10265358,
    "stId" : "R-CFA-381325",
    "displayName" : "EP300 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 90817 ],
    "identifier" : "A0A8I3P730",
    "standardIdentifier" : "uniprot:A0A8I3P730",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "EP300" ],
    "parents" : [ 10318599 ],
    "children" : [ ]
  }, {
    "dbId" : 3785707,
    "stId" : "R-ALL-3785707",
    "displayName" : "ROS [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90798 ],
    "identifier" : "26523",
    "standardIdentifier" : "chebi:26523",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10318606,
    "stId" : "R-CFA-9622899",
    "displayName" : "SIRT1,SIRT3 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 90803 ],
    "parents" : [ ],
    "children" : [ 10255648, 10318604 ]
  }, {
    "dbId" : 10243976,
    "stId" : "R-CFA-199289",
    "displayName" : "phospho-FOXO3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3N2V0",
    "standardIdentifier" : "uniprot:A0A8I3N2V0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO3" ],
    "parents" : [ 10318438 ],
    "children" : [ ]
  }, {
    "dbId" : 10231370,
    "stId" : "R-CFA-1445116",
    "displayName" : "YWHAQ [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PQU8",
    "standardIdentifier" : "uniprot:A0A8I3PQU8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "YWHAQ" ],
    "parents" : [ 10231372 ],
    "children" : [ ]
  }, {
    "dbId" : 10318730,
    "stId" : "R-CFA-9626931",
    "displayName" : "FOXO1:CREBBP [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90807 ],
    "parents" : [ ],
    "children" : [ 10254003, 10243952 ]
  }, {
    "dbId" : 10318597,
    "stId" : "R-CFA-9620514",
    "displayName" : "FOXO3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 90795 ],
    "identifier" : "A0A8I3N2V0",
    "standardIdentifier" : "uniprot:A0A8I3N2V0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO3" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113560,
    "stId" : "R-ALL-113560",
    "displayName" : "Ac-CoA [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90794 ],
    "identifier" : "57288",
    "standardIdentifier" : "chebi:57288",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10318599,
    "stId" : "R-CFA-9620507",
    "displayName" : "KAT2B,(EP300) [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 49646,
    "diagramIds" : [ 90797 ],
    "parents" : [ ],
    "children" : [ 10275696, 10265358 ]
  }, {
    "dbId" : 10243971,
    "stId" : "R-CFA-199306",
    "displayName" : "phospho-FOXO1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PLD0",
    "standardIdentifier" : "uniprot:A0A8I3PLD0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO1" ],
    "parents" : [ 10318438 ],
    "children" : [ ]
  }, {
    "dbId" : 10318458,
    "stId" : "R-CFA-9614653",
    "displayName" : "p-T32,S197,S262-FOXO4:YWHAZ dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90791 ],
    "parents" : [ ],
    "children" : [ 10231378, 10318442 ]
  }, {
    "dbId" : 10243956,
    "stId" : "R-CFA-199305",
    "displayName" : "FOXO3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 90793 ],
    "identifier" : "A0A8I3N2V0",
    "standardIdentifier" : "uniprot:A0A8I3N2V0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO3" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10318454,
    "stId" : "R-CFA-9614628",
    "displayName" : "p-T32,S253,S315-FOXO3:YWHAZ,YWHAQ,SFN [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90787 ],
    "parents" : [ ],
    "children" : [ 10318448, 10318440 ]
  }, {
    "dbId" : 10243952,
    "stId" : "R-CFA-199300",
    "displayName" : "FOXO1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 90806 ],
    "identifier" : "A0A8I3PLD0",
    "standardIdentifier" : "uniprot:A0A8I3PLD0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO1" ],
    "parents" : [ 10318730 ],
    "children" : [ ]
  }, {
    "dbId" : 10275696,
    "stId" : "R-CFA-352430",
    "displayName" : "KAT2B [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P556",
    "standardIdentifier" : "uniprot:A0A8I3P556",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "KAT2B" ],
    "parents" : [ 10318599 ],
    "children" : [ ]
  }, {
    "dbId" : 427498,
    "stId" : "R-ALL-427498",
    "displayName" : "2'-O-acetyl-ADP-ribose [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90801 ],
    "identifier" : "83767",
    "standardIdentifier" : "chebi:83767",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10318448,
    "stId" : "R-CFA-9614573",
    "displayName" : "YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 90785, 90782 ],
    "parents" : [ 10318450, 10318454 ],
    "children" : [ 10231378, 10231372 ]
  }, {
    "dbId" : 10318450,
    "stId" : "R-CFA-9614572",
    "displayName" : "p-T24,S256,S319-FOXO1:YWHAZ,YWHAQ,YWHAG,YWHAB [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90783 ],
    "parents" : [ ],
    "children" : [ 10247378, 10318448 ]
  }, {
    "dbId" : 10254003,
    "stId" : "R-CFA-193545",
    "displayName" : "CREBBP [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 90805 ],
    "identifier" : "A0A8I3MJJ8",
    "standardIdentifier" : "uniprot:A0A8I3MJJ8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CREBBP" ],
    "parents" : [ 10318730 ],
    "children" : [ ]
  }, {
    "dbId" : 2485002,
    "stId" : "R-ALL-2485002",
    "displayName" : "CoA-SH [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90796 ],
    "identifier" : "57287",
    "standardIdentifier" : "chebi:57287",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 427497,
    "stId" : "R-ALL-427497",
    "displayName" : "NAM [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90802 ],
    "identifier" : "17154",
    "standardIdentifier" : "chebi:17154",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10318444,
    "stId" : "R-CFA-9614416",
    "displayName" : "p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 90779 ],
    "parents" : [ ],
    "children" : [ 10247378, 10318442, 10318440 ]
  }, {
    "dbId" : 10318440,
    "stId" : "R-CFA-9614413",
    "displayName" : "phospho-FOXO3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 90786 ],
    "identifier" : "A0A8I3N2V0",
    "standardIdentifier" : "uniprot:A0A8I3N2V0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO3" ],
    "parents" : [ 10318444, 10318454 ],
    "children" : [ ]
  }, {
    "dbId" : 10318442,
    "stId" : "R-CFA-9614415",
    "displayName" : "phospho-FOXO4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 90789 ],
    "identifier" : "A0A8I3NW63",
    "standardIdentifier" : "uniprot:A0A8I3NW63",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO4" ],
    "parents" : [ 10318458, 10318444 ],
    "children" : [ ]
  }, {
    "dbId" : 10318438,
    "stId" : "R-CFA-199269",
    "displayName" : "p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 90778 ],
    "parents" : [ ],
    "children" : [ 10243971, 10243976, 10243981 ]
  }, {
    "dbId" : 10329121,
    "stId" : "R-CFA-1257604",
    "displayName" : "PIP3 activates AKT signaling",
    "schemaClass" : "Pathway",
    "speciesId" : 49646,
    "diagramIds" : [ 90811 ]
  }, {
    "dbId" : 10255648,
    "stId" : "R-CFA-427531",
    "displayName" : "SIRT1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 90822 ],
    "identifier" : "A0A8I3ME48",
    "standardIdentifier" : "uniprot:A0A8I3ME48",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10318606 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10318460,
    "stId" : "R-CFA-9614564",
    "displayName" : "14-3-3 proteins bind AKT-phosphorylated FOXO4",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10318446 ],
    "inputs" : [ 10231378, 10318442 ],
    "outputs" : [ 10318458 ],
    "efs" : [ ],
    "diagramIds" : [ 90788 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10318732,
    "stId" : "R-CFA-9626928",
    "displayName" : "CREBBP binds FOXO1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10254003, 10243952 ],
    "outputs" : [ 10318730 ],
    "efs" : [ ],
    "diagramIds" : [ 90804 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10318446,
    "stId" : "R-CFA-9614414",
    "displayName" : "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "following" : [ 10318460, 10318452, 10318456 ],
    "inputs" : [ 10318438 ],
    "outputs" : [ 10318444 ],
    "efs" : [ ],
    "diagramIds" : [ 90777 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10318456,
    "stId" : "R-CFA-9614562",
    "displayName" : "14-3-3 proteins bind AKT-phosphorylated FOXO3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10318446 ],
    "inputs" : [ 10318448, 10318440 ],
    "outputs" : [ 10318454 ],
    "efs" : [ ],
    "diagramIds" : [ 90784 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10318602,
    "stId" : "R-CFA-9620515",
    "displayName" : "KAT2B,EP300 acetylate FOXO3 under oxidative stress",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10318609 ],
    "inputs" : [ 113560, 10243956 ],
    "outputs" : [ 2485002, 10318597 ],
    "catalysts" : [ 10318599 ],
    "efs" : [ ],
    "activators" : [ 3785707 ],
    "diagramIds" : [ 90792 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10318452,
    "stId" : "R-CFA-9614423",
    "displayName" : "14-3-3 proteins bind AKT-phosphorylated FOXO1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10318446 ],
    "inputs" : [ 10247378, 10318448 ],
    "outputs" : [ 10318450 ],
    "efs" : [ ],
    "diagramIds" : [ 90780 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10318609,
    "stId" : "R-CFA-9620532",
    "displayName" : "SIRT1,SIRT3 deacetylate FOXO3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10318602 ],
    "inputs" : [ 10318597, 427523 ],
    "outputs" : [ 427497, 427498, 10243956 ],
    "catalysts" : [ 10318606 ],
    "efs" : [ ],
    "diagramIds" : [ 90799 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10331785,
    "stId" : "R-CFA-9614399",
    "displayName" : "Regulation of localization of FOXO transcription factors",
    "events" : [ 10318460, 10318446, 10318456, 10318452 ]
  }, {
    "dbId" : 10331799,
    "stId" : "R-CFA-9617629",
    "displayName" : "Regulation of FOXO transcriptional activity by acetylation",
    "events" : [ 10318732, 10318602, 10318609 ]
  } ]
}