{
  "dbId" : 10331113,
  "stId" : "R-CFA-5668599",
  "speciesName" : "Canis familiaris",
  "nodes" : [ {
    "dbId" : 10330261,
    "stId" : "R-CFA-1222556",
    "displayName" : "ROS and RNS production in phagocytes",
    "schemaClass" : "Pathway",
    "speciesId" : 49646,
    "diagramIds" : [ 90685 ]
  }, {
    "dbId" : 71185,
    "stId" : "R-ALL-71185",
    "displayName" : "ferroheme [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "60344",
    "standardIdentifier" : "chebi:60344",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10286568 ],
    "children" : [ ]
  }, {
    "dbId" : 10266248,
    "stId" : "R-CFA-1996217",
    "displayName" : "NOX2 complex [phagocytic vesicle membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90633 ],
    "parents" : [ 10292548 ],
    "children" : [ 10266243, 10266231, 10266246, 10266239 ]
  }, {
    "dbId" : 10266246,
    "stId" : "R-CFA-1996211",
    "displayName" : "phospho-NCF2 [phagolysosome]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3RS65",
    "standardIdentifier" : "uniprot:A0A8I3RS65",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NCF2" ],
    "parents" : [ 10266248 ],
    "children" : [ ]
  }, {
    "dbId" : 10234753,
    "stId" : "R-CFA-442641",
    "displayName" : "RAC1:GTP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90622 ],
    "parents" : [ 10292580, 10292595, 10286572 ],
    "children" : [ 29438, 10234751 ]
  }, {
    "dbId" : 10266243,
    "stId" : "R-CFA-1996221",
    "displayName" : "phospho-NCF4 [phagolysosome]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3N2R2",
    "standardIdentifier" : "uniprot:A0A8I3N2R2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NCF4" ],
    "parents" : [ 10266248 ],
    "children" : [ ]
  }, {
    "dbId" : 10292540,
    "stId" : "R-CFA-5668620",
    "displayName" : "RAC2 [phagocytic vesicle membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3N5M3",
    "standardIdentifier" : "uniprot:A0A8I3N5M3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RAC2" ],
    "parents" : [ 10292544 ],
    "children" : [ ]
  }, {
    "dbId" : 74016,
    "stId" : "R-ALL-74016",
    "displayName" : "Ca2+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "29108",
    "standardIdentifier" : "chebi:29108",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10292559 ],
    "children" : [ ]
  }, {
    "dbId" : 10292542,
    "stId" : "R-CFA-5668620-2",
    "displayName" : "RAC3 [phagocytic vesicle membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3N7V9",
    "standardIdentifier" : "uniprot:A0A8I3N7V9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RAC3" ],
    "parents" : [ 10292544 ],
    "children" : [ ]
  }, {
    "dbId" : 1629751,
    "stId" : "R-ALL-1629751",
    "displayName" : "PI3P [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90638 ],
    "identifier" : "58088",
    "standardIdentifier" : "chebi:58088",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10329901,
    "stId" : "R-CFA-983169",
    "displayName" : "Class I MHC mediated antigen processing & presentation",
    "schemaClass" : "Pathway",
    "speciesId" : 49646,
    "diagramIds" : [ 90684 ]
  }, {
    "dbId" : 10256044,
    "stId" : "R-CFA-428935",
    "displayName" : "phospho-p-T180,Y182-MAPK14 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "O02812",
    "standardIdentifier" : "uniprot:O02812",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10286383 ],
    "children" : [ ]
  }, {
    "dbId" : 10233519,
    "stId" : "R-CFA-109853",
    "displayName" : "phospho-MAPK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PZP0",
    "standardIdentifier" : "uniprot:A0A8I3PZP0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAPK1" ],
    "parents" : [ 10239187 ],
    "children" : [ ]
  }, {
    "dbId" : 10286383,
    "stId" : "R-CFA-170997",
    "displayName" : "p-p38 MAPK alpha/beta [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 90670 ],
    "parents" : [ ],
    "children" : [ 10258248, 10256044 ]
  }, {
    "dbId" : 29364,
    "stId" : "R-ALL-29364",
    "displayName" : "NADPH [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90626, 90645, 90653 ],
    "identifier" : "57783",
    "standardIdentifier" : "chebi:57783",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29366,
    "stId" : "R-ALL-29366",
    "displayName" : "NADP+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90657, 90629, 90647 ],
    "identifier" : "58349",
    "standardIdentifier" : "chebi:58349",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90675, 90660, 90664 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90661, 90676, 90667 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10329761,
    "stId" : "R-CFA-194138",
    "displayName" : "Signaling by VEGF",
    "schemaClass" : "Pathway",
    "speciesId" : 49646,
    "diagramIds" : [ 90683 ]
  }, {
    "dbId" : 10292572,
    "stId" : "R-CFA-5668693",
    "displayName" : "NOXA1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PH10",
    "standardIdentifier" : "uniprot:A0A8I3PH10",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NOXA1" ],
    "parents" : [ 10292578, 10292591 ],
    "children" : [ ]
  }, {
    "dbId" : 352327,
    "stId" : "R-ALL-352327",
    "displayName" : "O2 [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90627, 90644, 90654 ],
    "identifier" : "15379",
    "standardIdentifier" : "chebi:15379",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10292568,
    "stId" : "R-CFA-5212696",
    "displayName" : "NOX1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NQY4",
    "standardIdentifier" : "uniprot:A0A8I3NQY4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NOX1" ],
    "parents" : [ 10292578 ],
    "children" : [ ]
  }, {
    "dbId" : 2000345,
    "stId" : "R-ALL-2000345",
    "displayName" : "O2.- [phagolysosome]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90637 ],
    "identifier" : "18421",
    "standardIdentifier" : "chebi:18421",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29768,
    "stId" : "R-ALL-29768",
    "displayName" : "AA [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "32395",
    "standardIdentifier" : "chebi:32395",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10292559 ],
    "children" : [ ]
  }, {
    "dbId" : 10239189,
    "stId" : "R-CFA-1268261",
    "displayName" : "p-T,Y MAPK dimers [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 90668 ],
    "parents" : [ ],
    "children" : [ 10239187, 10239185 ]
  }, {
    "dbId" : 29386,
    "stId" : "R-ALL-29386",
    "displayName" : "FAD [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "57692",
    "standardIdentifier" : "chebi:57692",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10286568 ],
    "children" : [ ]
  }, {
    "dbId" : 10292561,
    "stId" : "R-CFA-9626792",
    "displayName" : "NOX2 complex:S100A8:S100A9:Ca2+ [phagocytic vesicle membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90639 ],
    "parents" : [ ],
    "children" : [ 10292548, 10292559 ]
  }, {
    "dbId" : 10239185,
    "stId" : "R-CFA-109844",
    "displayName" : "p-T202, Y204 MAPK3 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10239189 ],
    "children" : [ 10239183 ]
  }, {
    "dbId" : 10286417,
    "stId" : "R-CFA-5218754",
    "displayName" : "p-PKCA,p-PKCB,p-PKCZ,p-PKCD [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 90678 ],
    "parents" : [ ],
    "children" : [ 10286407, 10286410, 10286415, 10286413 ]
  }, {
    "dbId" : 10300368,
    "stId" : "R-CFA-6798183",
    "displayName" : "PIK3C3:PIK3R4 [phagocytic vesicle membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90662 ],
    "parents" : [ ],
    "children" : [ 10300366, 10300364 ]
  }, {
    "dbId" : 10239187,
    "stId" : "R-CFA-109855",
    "displayName" : "p-T185,Y187 MAPK1 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10239189 ],
    "children" : [ 10233519 ]
  }, {
    "dbId" : 10292557,
    "stId" : "R-CFA-9626831",
    "displayName" : "S100A8:S100A9 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10292559 ],
    "children" : [ 10292555, 10292553 ]
  }, {
    "dbId" : 10286413,
    "stId" : "R-CFA-5218728",
    "displayName" : "phospho-p-T500-PRKCB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MI53",
    "standardIdentifier" : "uniprot:A0A8I3MI53",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10286417 ],
    "children" : [ ]
  }, {
    "dbId" : 10300364,
    "stId" : "R-CFA-6798182",
    "displayName" : "PIK3C3 [phagocytic vesicle membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MWD3",
    "standardIdentifier" : "uniprot:A0A8I3MWD3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PIK3C3" ],
    "parents" : [ 10300368 ],
    "children" : [ ]
  }, {
    "dbId" : 10292559,
    "stId" : "R-CFA-9626862",
    "displayName" : "S100A8:S100A9:AA:Ca2+ [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90680 ],
    "parents" : [ 10292561 ],
    "children" : [ 29768, 74016, 10292557 ]
  }, {
    "dbId" : 1524165,
    "stId" : "R-ALL-1524165",
    "displayName" : "PI [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90659 ],
    "identifier" : "57880",
    "standardIdentifier" : "chebi:57880",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10239183,
    "stId" : "R-CFA-109842",
    "displayName" : "phospho-MAPK3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3RQD0",
    "standardIdentifier" : "uniprot:A0A8I3RQD0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAPK3" ],
    "parents" : [ 10239185 ],
    "children" : [ ]
  }, {
    "dbId" : 10286415,
    "stId" : "R-CFA-5218746",
    "displayName" : "phospho-PRKCD [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PZJ7",
    "standardIdentifier" : "uniprot:A0A8I3PZJ7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PRKCD" ],
    "parents" : [ 10286417 ],
    "children" : [ ]
  }, {
    "dbId" : 10300366,
    "stId" : "R-CFA-6798171",
    "displayName" : "PIK3R4 [phagocytic vesicle membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3QFN1",
    "standardIdentifier" : "uniprot:A0A8I3QFN1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PIK3R4" ],
    "parents" : [ 10300368 ],
    "children" : [ ]
  }, {
    "dbId" : 3299686,
    "stId" : "R-ALL-3299686",
    "displayName" : "O2.- [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90630, 90648, 90655 ],
    "identifier" : "18421",
    "standardIdentifier" : "chebi:18421",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10292553,
    "stId" : "R-CFA-9626834",
    "displayName" : "LOC119881359 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MUM3",
    "standardIdentifier" : "uniprot:A0A8I3MUM3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC119881359" ],
    "parents" : [ 10292557 ],
    "children" : [ ]
  }, {
    "dbId" : 10258248,
    "stId" : "R-CFA-171009",
    "displayName" : "phospho-MAPK11 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MVQ2",
    "standardIdentifier" : "uniprot:A0A8I3MVQ2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAPK11" ],
    "parents" : [ 10286383 ],
    "children" : [ ]
  }, {
    "dbId" : 10286410,
    "stId" : "R-CFA-5218731",
    "displayName" : "phospho-p-T497-PRKCA [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PUQ8",
    "standardIdentifier" : "uniprot:A0A8I3PUQ8",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10286417 ],
    "children" : [ ]
  }, {
    "dbId" : 10292555,
    "stId" : "R-CFA-9626869",
    "displayName" : "S100A9 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MLA2",
    "standardIdentifier" : "uniprot:A0A8I3MLA2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "S100A9" ],
    "parents" : [ 10292557 ],
    "children" : [ ]
  }, {
    "dbId" : 10292548,
    "stId" : "R-CFA-5668618",
    "displayName" : "NOX2 complex:RAC2:GTP [phagocytic vesicle membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90634 ],
    "parents" : [ 10292561 ],
    "children" : [ 10292546, 10266248 ]
  }, {
    "dbId" : 10286407,
    "stId" : "R-CFA-437181",
    "displayName" : "phospho-p-T410-PRKCZ [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NXR9",
    "standardIdentifier" : "uniprot:A0A8I3NXR9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10286417 ],
    "children" : [ ]
  }, {
    "dbId" : 70106,
    "stId" : "R-ALL-70106",
    "displayName" : "H+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90656, 90628, 90646 ],
    "identifier" : "15378",
    "standardIdentifier" : "chebi:15378",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10292544,
    "stId" : "R-CFA-5668620-3",
    "displayName" : "Homologues of RAC2 [phagocytic vesicle membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10292546 ],
    "children" : [ 10292542, 10292540 ]
  }, {
    "dbId" : 10292546,
    "stId" : "R-CFA-5668609",
    "displayName" : "RAC2:GTP [phagocytic vesicle membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90632 ],
    "parents" : [ 10292548 ],
    "children" : [ 29438, 10292544 ]
  }, {
    "dbId" : 10318717,
    "stId" : "R-CFA-9626870",
    "displayName" : "NCF1:NCF2:NCF4 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90665 ],
    "parents" : [ ],
    "children" : [ 10265712, 10265716, 10265708 ]
  }, {
    "dbId" : 10234751,
    "stId" : "R-CFA-351141",
    "displayName" : "RAC1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "P62999",
    "standardIdentifier" : "uniprot:P62999",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10234753 ],
    "children" : [ ]
  }, {
    "dbId" : 10266239,
    "stId" : "R-CFA-1996220",
    "displayName" : "phospho-NCF1 [phagolysosome]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MKD2",
    "standardIdentifier" : "uniprot:A0A8I3MKD2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NCF1" ],
    "parents" : [ 10266248 ],
    "children" : [ ]
  }, {
    "dbId" : 10318713,
    "stId" : "R-CFA-9626814",
    "displayName" : "PIN1:p-S-6S-NCF1:NCF2:NCF4 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90677 ],
    "parents" : [ ],
    "children" : [ 10318704, 10265712, 10318711, 10265716 ]
  }, {
    "dbId" : 10265716,
    "stId" : "R-CFA-1222707",
    "displayName" : "NCF4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3N2R2",
    "standardIdentifier" : "uniprot:A0A8I3N2R2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NCF4" ],
    "parents" : [ 10318713, 10318706, 10286570, 10318702, 10318717 ],
    "children" : [ ]
  }, {
    "dbId" : 10318711,
    "stId" : "R-CFA-9626854",
    "displayName" : "phospho-NCF1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MKD2",
    "standardIdentifier" : "uniprot:A0A8I3MKD2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NCF1" ],
    "parents" : [ 10318713 ],
    "children" : [ ]
  }, {
    "dbId" : 10266231,
    "stId" : "R-CFA-1996225",
    "displayName" : "flavocytochrome b558 catalytic core [phagocytic vesicle membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10266248 ],
    "children" : [ 10265698, 10265702 ]
  }, {
    "dbId" : 10265712,
    "stId" : "R-CFA-1222600",
    "displayName" : "NCF2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3RS65",
    "standardIdentifier" : "uniprot:A0A8I3RS65",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NCF2" ],
    "parents" : [ 10318713, 10318706, 10292591, 10286570, 10318702, 10318717 ],
    "children" : [ ]
  }, {
    "dbId" : 10292593,
    "stId" : "R-CFA-5668734",
    "displayName" : "NOX3 Complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90650 ],
    "parents" : [ 10292595 ],
    "children" : [ 10286564, 10292591, 10265708, 10292589 ]
  }, {
    "dbId" : 10318704,
    "stId" : "R-CFA-9626823",
    "displayName" : "PIN1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 90672 ],
    "identifier" : "A0A8I3S3C2",
    "standardIdentifier" : "uniprot:A0A8I3S3C2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PIN1" ],
    "parents" : [ 10318713, 10318706 ],
    "children" : [ ]
  }, {
    "dbId" : 10292595,
    "stId" : "R-CFA-5668738",
    "displayName" : "NOX3 complex:RAC1:GTP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90651 ],
    "parents" : [ ],
    "children" : [ 10234753, 10292593 ]
  }, {
    "dbId" : 10318706,
    "stId" : "R-CFA-9626778",
    "displayName" : "PIN1:p-S-345-NCF1:NCF2:NCF4 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90673 ],
    "parents" : [ ],
    "children" : [ 10318704, 10265712, 10265716, 10318700 ]
  }, {
    "dbId" : 10265708,
    "stId" : "R-CFA-1222296",
    "displayName" : "NCF1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MKD2",
    "standardIdentifier" : "uniprot:A0A8I3MKD2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NCF1" ],
    "parents" : [ 10292593, 10286570, 10318717 ],
    "children" : [ ]
  }, {
    "dbId" : 10292589,
    "stId" : "R-CFA-5668728",
    "displayName" : "NOX3 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MKU3",
    "standardIdentifier" : "uniprot:A0A8I3MKU3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NOX3" ],
    "parents" : [ 10292593 ],
    "children" : [ ]
  }, {
    "dbId" : 10286572,
    "stId" : "R-CFA-5218774",
    "displayName" : "NOX2 complex:RAC1:GTP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90624 ],
    "parents" : [ ],
    "children" : [ 10234753, 10286570 ]
  }, {
    "dbId" : 10318700,
    "stId" : "R-CFA-9626824",
    "displayName" : "phospho-NCF1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MKD2",
    "standardIdentifier" : "uniprot:A0A8I3MKD2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NCF1" ],
    "parents" : [ 10318706, 10318702 ],
    "children" : [ ]
  }, {
    "dbId" : 10292591,
    "stId" : "R-CFA-5668743",
    "displayName" : "NCF2,NOXA1 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10292593 ],
    "children" : [ 10265712, 10292572 ]
  }, {
    "dbId" : 10318702,
    "stId" : "R-CFA-9626850",
    "displayName" : "p-S-345-NCF1:NCF2:NCF4 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90666 ],
    "parents" : [ ],
    "children" : [ 10265712, 10265716, 10318700 ]
  }, {
    "dbId" : 10286568,
    "stId" : "R-CFA-5218783",
    "displayName" : "Cytochrome b-245 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10286570 ],
    "children" : [ 10286566, 29386, 10286564, 71185 ]
  }, {
    "dbId" : 10286570,
    "stId" : "R-CFA-5218791",
    "displayName" : "NOX2 complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90623 ],
    "parents" : [ 10286572 ],
    "children" : [ 10265712, 10265716, 10286568, 10265708 ]
  }, {
    "dbId" : 1236709,
    "stId" : "R-ALL-1236709",
    "displayName" : "O2 [phagolysosome]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 90636 ],
    "identifier" : "15379",
    "standardIdentifier" : "chebi:15379",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10286564,
    "stId" : "R-CFA-5218744",
    "displayName" : "CYBA [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MT07",
    "standardIdentifier" : "uniprot:A0A8I3MT07",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CYBA" ],
    "parents" : [ 10292578, 10292593, 10286568 ],
    "children" : [ ]
  }, {
    "dbId" : 10292580,
    "stId" : "R-CFA-5668712",
    "displayName" : "NOX1 complex:RAC1:GTP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90642 ],
    "parents" : [ ],
    "children" : [ 10292578, 10234753 ]
  }, {
    "dbId" : 10265702,
    "stId" : "R-CFA-1222445",
    "displayName" : "CYBB [phagocytic vesicle membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PJS5",
    "standardIdentifier" : "uniprot:A0A8I3PJS5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CYBB" ],
    "parents" : [ 10266231 ],
    "children" : [ ]
  }, {
    "dbId" : 10286566,
    "stId" : "R-CFA-5218720",
    "displayName" : "CYBB [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PJS5",
    "standardIdentifier" : "uniprot:A0A8I3PJS5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CYBB" ],
    "parents" : [ 10286568 ],
    "children" : [ ]
  }, {
    "dbId" : 10292576,
    "stId" : "R-CFA-5668699",
    "displayName" : "NOXO1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P2R7",
    "standardIdentifier" : "uniprot:A0A8I3P2R7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NOXO1" ],
    "parents" : [ 10292578 ],
    "children" : [ ]
  }, {
    "dbId" : 29438,
    "stId" : "R-ALL-29438",
    "displayName" : "GTP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "37565",
    "standardIdentifier" : "chebi:37565",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10292546, 10234753 ],
    "children" : [ ]
  }, {
    "dbId" : 10265698,
    "stId" : "R-CFA-1222756",
    "displayName" : "CYBA [phagocytic vesicle membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MT07",
    "standardIdentifier" : "uniprot:A0A8I3MT07",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CYBA" ],
    "parents" : [ 10266231 ],
    "children" : [ ]
  }, {
    "dbId" : 10292578,
    "stId" : "R-CFA-5668698",
    "displayName" : "NOX1 Complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 90641 ],
    "parents" : [ 10292580 ],
    "children" : [ 10292576, 10286564, 10292568, 10292572 ]
  } ],
  "edges" : [ {
    "dbId" : 10318719,
    "stId" : "R-CFA-9626832",
    "displayName" : "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10318709 ],
    "inputs" : [ 113592, 10318717 ],
    "outputs" : [ 29370, 10318702 ],
    "catalysts" : [ 10239189 ],
    "efs" : [ ],
    "diagramIds" : [ 90663 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10292600,
    "stId" : "R-CFA-5668735",
    "displayName" : "RAC1:GTP binds NOX3 complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10292598 ],
    "inputs" : [ 10234753, 10292593 ],
    "outputs" : [ 10292595 ],
    "efs" : [ ],
    "diagramIds" : [ 90649 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10318715,
    "stId" : "R-CFA-9626817",
    "displayName" : "PKC phosphorylates NCF1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10318709 ],
    "inputs" : [ 10318706, 113592 ],
    "outputs" : [ 29370, 10318713 ],
    "catalysts" : [ 10286417 ],
    "efs" : [ ],
    "diagramIds" : [ 90674 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10318709,
    "stId" : "R-CFA-9626816",
    "displayName" : "PIN1 binds p-S345-NCF1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10318724, 10318719 ],
    "following" : [ 10318715 ],
    "inputs" : [ 10318704, 10318702 ],
    "outputs" : [ 10318706 ],
    "catalysts" : [ 10318704 ],
    "efs" : [ ],
    "diagramIds" : [ 90671 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10292598,
    "stId" : "R-CFA-5668731",
    "displayName" : "NOX3 complex:RAC1:GTP generates superoxide from oxygen",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10292600 ],
    "inputs" : [ 29364, 352327 ],
    "outputs" : [ 70106, 29366, 3299686 ],
    "catalysts" : [ 10292595 ],
    "efs" : [ ],
    "diagramIds" : [ 90652 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10292563,
    "stId" : "R-CFA-5668629",
    "displayName" : "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10292550 ],
    "inputs" : [ 1236709, 29364 ],
    "outputs" : [ 70106, 2000345, 29366 ],
    "catalysts" : [ 10292548 ],
    "efs" : [ ],
    "activators" : [ 1629751, 10292561 ],
    "diagramIds" : [ 90635 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10300371,
    "stId" : "R-CFA-6798174",
    "displayName" : "PIK3C3:PIK3R4 phosphorylates PI to PI3P",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 113592, 1524165 ],
    "outputs" : [ 1629751, 29370 ],
    "catalysts" : [ 10300368 ],
    "efs" : [ ],
    "diagramIds" : [ 90658 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10286574,
    "stId" : "R-CFA-5218827",
    "displayName" : "NADPH oxidase 2 (NOX2) complex binds RAC1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10286599 ],
    "inputs" : [ 10234753, 10286570 ],
    "outputs" : [ 10286572 ],
    "efs" : [ ],
    "diagramIds" : [ 90621 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10292585,
    "stId" : "R-CFA-5668718",
    "displayName" : "NOX1 complex:RAC1:GTP generates superoxide from oxygen",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 29364, 352327 ],
    "outputs" : [ 70106, 29366, 3299686 ],
    "catalysts" : [ 10292580 ],
    "efs" : [ ],
    "diagramIds" : [ 90643 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10318724,
    "stId" : "R-CFA-9626880",
    "displayName" : "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10318709 ],
    "inputs" : [ 113592, 10318717 ],
    "outputs" : [ 29370, 10318702 ],
    "catalysts" : [ 10286383 ],
    "efs" : [ ],
    "diagramIds" : [ 90669 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10286599,
    "stId" : "R-CFA-5218841",
    "displayName" : "NADPH oxidase 2 generates superoxide from oxygen",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10286574 ],
    "inputs" : [ 29364, 352327 ],
    "outputs" : [ 70106, 29366, 3299686 ],
    "catalysts" : [ 10286572 ],
    "efs" : [ ],
    "diagramIds" : [ 90625 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10292550,
    "stId" : "R-CFA-5668605",
    "displayName" : "RAC2:GTP binds NOX2 complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10318721, 10292563 ],
    "inputs" : [ 10292546, 10266248 ],
    "outputs" : [ 10292548 ],
    "efs" : [ ],
    "diagramIds" : [ 90631 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10292582,
    "stId" : "R-CFA-5668714",
    "displayName" : "RAC1:GTP binds NOX1 complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10292578, 10234753 ],
    "outputs" : [ 10292580 ],
    "efs" : [ ],
    "diagramIds" : [ 90640 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10318721,
    "stId" : "R-CFA-9626848",
    "displayName" : "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10292550 ],
    "inputs" : [ 10292548, 10292559 ],
    "outputs" : [ 10292561 ],
    "efs" : [ ],
    "diagramIds" : [ 90679 ],
    "entityFunctionalStatus" : [ ]
  } ]
}