{ "dbId" : 10329141, "stId" : "R-CFA-5576891", "speciesName" : "Canis familiaris", "nodes" : [ { "dbId" : 10288797, "stId" : "R-CFA-1296323", "displayName" : "KCNK5 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3NUT1", "standardIdentifier" : "uniprot:A0A8I3NUT1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNK5" ], "parents" : [ 10288799 ], "children" : [ ] }, { "dbId" : 10288799, "stId" : "R-CFA-5578911", "displayName" : "KCNK5 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288803 ], "children" : [ 10288797 ] }, { "dbId" : 10288793, "stId" : "R-CFA-5578923", "displayName" : "KCNK4 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288803 ], "children" : [ 10267051 ] }, { "dbId" : 10288789, "stId" : "R-CFA-5578918", "displayName" : "KCNK12 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288803 ], "children" : [ 10288787 ] }, { "dbId" : 10288791, "stId" : "R-CFA-5578928", "displayName" : "KCNK13 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288803 ], "children" : [ 10267145 ] }, { "dbId" : 10288787, "stId" : "R-CFA-1296341", "displayName" : "KCNK12 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MTD8", "standardIdentifier" : "uniprot:A0A8I3MTD8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNK12" ], "parents" : [ 10288789 ], "children" : [ ] }, { "dbId" : 10288781, "stId" : "R-CFA-5578908", "displayName" : "KCNK15 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288803 ], "children" : [ 10288779 ] }, { "dbId" : 10288783, "stId" : "R-CFA-5578904", "displayName" : "KCNK10 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288803 ], "children" : [ 10267047 ] }, { "dbId" : 10288779, "stId" : "R-CFA-1296336", "displayName" : "KCNK15 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3S0J2", "standardIdentifier" : "uniprot:A0A8I3S0J2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNK15" ], "parents" : [ 10288781 ], "children" : [ ] }, { "dbId" : 10288770, "stId" : "R-CFA-5490311", "displayName" : "CORIN [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "diagramIds" : [ 53293 ], "identifier" : "A0A8I3N7Q6", "standardIdentifier" : "uniprot:A0A8I3N7Q6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CORIN" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 10265279, "stId" : "R-CFA-975282", "displayName" : "KCNJ12 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "F6KIF6", "standardIdentifier" : "uniprot:F6KIF6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNJ12" ], "parents" : [ 10266867 ], "children" : [ ] }, { "dbId" : 10235064, "stId" : "R-CFA-418292", "displayName" : "IP3R tetramer [platelet dense tubular network membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10235066 ], "children" : [ 10235062 ] }, { "dbId" : 10235066, "stId" : "R-CFA-139839", "displayName" : "IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53273 ], "parents" : [ ], "children" : [ 10235064, 141090, 139826 ] }, { "dbId" : 10235060, "stId" : "R-CFA-3325593", "displayName" : "ITPR1 [platelet dense tubular network membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3NKB2", "standardIdentifier" : "uniprot:A0A8I3NKB2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ITPR1" ], "parents" : [ 10235062 ], "children" : [ ] }, { "dbId" : 10235062, "stId" : "R-CFA-418284", "displayName" : "IP3R subunits [platelet dense tubular network membrane]", "schemaClass" : "DefinedSet", "speciesId" : 49646, "parents" : [ 10235064 ], "children" : [ 10235056, 10235060, 10235052 ] }, { "dbId" : 10265271, "stId" : "R-CFA-975378", "displayName" : "KCNJ2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "Q9MYY9", "standardIdentifier" : "uniprot:Q9MYY9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNJ2" ], "parents" : [ 10266867 ], "children" : [ ] }, { "dbId" : 10235056, "stId" : "R-CFA-418283", "displayName" : "ITPR3 [platelet dense tubular network membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3Q2P2", "standardIdentifier" : "uniprot:A0A8I3Q2P2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ITPR3" ], "parents" : [ 10235062 ], "children" : [ ] }, { "dbId" : 139826, "stId" : "R-ALL-139826", "displayName" : "I(1,4,5)P3 [platelet dense tubular network membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "203600", "standardIdentifier" : "chebi:203600", "referenceType" : "ReferenceMolecule", "parents" : [ 10235066 ], "children" : [ ] }, { "dbId" : 10235052, "stId" : "R-CFA-418281", "displayName" : "ITPR2 [platelet dense tubular network membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3PW88", "standardIdentifier" : "uniprot:A0A8I3PW88", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ITPR2" ], "parents" : [ 10235062 ], "children" : [ ] }, { "dbId" : 139827, "stId" : "R-ALL-139827", "displayName" : "Ca2+ [platelet dense tubular network lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53271 ], "identifier" : "29108", "standardIdentifier" : "chebi:29108", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10288801, "stId" : "R-CFA-5578900", "displayName" : "KCNK9 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288803 ], "children" : [ 10267183 ] }, { "dbId" : 10288803, "stId" : "R-CFA-5578913", "displayName" : "KCNK dimers [plasma membrane]", "schemaClass" : "CandidateSet", "speciesId" : 49646, "diagramIds" : [ 53216 ], "parents" : [ ], "children" : [ 10267168, 10267179, 10267162, 10288781, 10288801, 10288791, 10267205, 10288789, 10267156, 10267211, 10288793, 10288799, 10288783, 10267196 ] }, { "dbId" : 10293458, "stId" : "R-CFA-9691563", "displayName" : "KCNJ11:ABCC9:nicorandil [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53286 ], "parents" : [ ], "children" : [ 9691477, 10293455 ] }, { "dbId" : 10293455, "stId" : "R-CFA-5678267", "displayName" : "KCNJ11:ABCC9 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53285 ], "parents" : [ 10293458 ], "children" : [ 10248291, 10267383 ] }, { "dbId" : 10298568, "stId" : "R-CFA-6784600", "displayName" : "NPR1 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53295 ], "parents" : [ 10298570 ], "children" : [ 10298566 ] }, { "dbId" : 10298570, "stId" : "R-CFA-6784597", "displayName" : "NPPA(124-151):NPR1 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53296 ], "parents" : [ ], "children" : [ 10298568, 10288766 ] }, { "dbId" : 10298566, "stId" : "R-CFA-5490308", "displayName" : "NPR1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MHU3", "standardIdentifier" : "uniprot:A0A8I3MHU3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NPR1" ], "parents" : [ 10298568 ], "children" : [ ] }, { "dbId" : 10289401, "stId" : "R-CFA-5617181", "displayName" : "ATP2B4:NOS1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53281 ], "parents" : [ ], "children" : [ 10254375, 10254349 ] }, { "dbId" : 10266869, "stId" : "R-CFA-1299200", "displayName" : "KCNJ tetramer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53214 ], "parents" : [ ], "children" : [ 10266867 ] }, { "dbId" : 10267383, "stId" : "R-CFA-1369054", "displayName" : "ABCC9 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3NNW7", "standardIdentifier" : "uniprot:A0A8I3NNW7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ABCC9" ], "parents" : [ 10293455 ], "children" : [ ] }, { "dbId" : 29804, "stId" : "R-ALL-29804", "displayName" : "K+ [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53284, 53223, 53256, 53227, 53213 ], "identifier" : "29103", "standardIdentifier" : "chebi:29103", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10266865, "stId" : "R-CFA-1296031", "displayName" : "KCNJ14 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3RRG3", "standardIdentifier" : "uniprot:A0A8I3RRG3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNJ14" ], "parents" : [ 10266867 ], "children" : [ ] }, { "dbId" : 9614079, "stId" : "R-ALL-9614079", "displayName" : "amlodipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "6981", "standardIdentifier" : "iuphar.ligand:6981", "chebiIdentifier" : "chebi:2668", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 10276081, "stId" : "R-CFA-2089937", "displayName" : "TRPC1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3Q281", "standardIdentifier" : "uniprot:A0A8I3Q281", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TRPC1" ], "parents" : [ 10276083 ], "children" : [ ] }, { "dbId" : 10266867, "stId" : "R-CFA-1296069", "displayName" : "KCNJs [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 49646, "parents" : [ 10266869 ], "children" : [ 10266865, 10265271, 10265279 ] }, { "dbId" : 10276083, "stId" : "R-CFA-2089954", "displayName" : "STIM1:TRPC1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53269 ], "parents" : [ ], "children" : [ 10276081, 10265502 ] }, { "dbId" : 10267166, "stId" : "R-CFA-1296321", "displayName" : "KCNK6 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MV05", "standardIdentifier" : "uniprot:A0A8I3MV05", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNK6" ], "parents" : [ 10267168 ], "children" : [ ] }, { "dbId" : 9613840, "stId" : "R-ALL-9613840", "displayName" : "Class III (KCNA5) antiarrhythmics [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 0, "diagramIds" : [ 53307 ], "parents" : [ 10318417 ], "children" : [ 9613844, 9613841 ] }, { "dbId" : 10288671, "stId" : "R-CFA-5577088", "displayName" : "KCND tetramer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288689 ], "children" : [ 10266974 ] }, { "dbId" : 9613841, "stId" : "R-ALL-9613841", "displayName" : "dronedarone [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "7465", "standardIdentifier" : "iuphar.ligand:7465", "chebiIdentifier" : "chebi:50659", "parents" : [ 9613840 ], "children" : [ ] }, { "dbId" : 10267160, "stId" : "R-CFA-1296345", "displayName" : "KCNK1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MR75", "standardIdentifier" : "uniprot:A0A8I3MR75", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNK1" ], "parents" : [ 10267162 ], "children" : [ ] }, { "dbId" : 10267162, "stId" : "R-CFA-1299252", "displayName" : "TWIK1 dimers [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288803 ], "children" : [ 10267160 ] }, { "dbId" : 9613844, "stId" : "R-ALL-9613844", "displayName" : "amiodarone [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "2566", "standardIdentifier" : "iuphar.ligand:2566", "chebiIdentifier" : "chebi:2663", "parents" : [ 9613840 ], "children" : [ ] }, { "dbId" : 10288666, "stId" : "R-CFA-9614114", "displayName" : "Class IV antihypertensives:LTCC multimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53221 ], "parents" : [ ], "children" : [ 9614108, 10288663 ] }, { "dbId" : 10267156, "stId" : "R-CFA-1299253", "displayName" : "KCNK7 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288803 ], "children" : [ 10267154 ] }, { "dbId" : 10288661, "stId" : "R-CFA-5577209", "displayName" : "CACNA2D2a:CACNA2D2d [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288663 ], "children" : [ 10288659, 10288657 ] }, { "dbId" : 10288663, "stId" : "R-CFA-5577111", "displayName" : "LTCC multimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53220 ], "parents" : [ 10288666 ], "children" : [ 10288661, 10288645, 10248266, 10288655 ] }, { "dbId" : 10288657, "stId" : "R-CFA-5577186", "displayName" : "CACNA2D2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3P8U8", "standardIdentifier" : "uniprot:A0A8I3P8U8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CACNA2D2" ], "parents" : [ 10288661 ], "children" : [ ] }, { "dbId" : 10267154, "stId" : "R-CFA-1296319", "displayName" : "KCNK7 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3P863", "standardIdentifier" : "uniprot:A0A8I3P863", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNK7" ], "parents" : [ 10267156 ], "children" : [ ] }, { "dbId" : 10288659, "stId" : "R-CFA-5577141", "displayName" : "CACNA2D2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3P8U8", "standardIdentifier" : "uniprot:A0A8I3P8U8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CACNA2D2" ], "parents" : [ 10288661 ], "children" : [ ] }, { "dbId" : 10288653, "stId" : "R-CFA-210519", "displayName" : "CACNG7 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MK78", "standardIdentifier" : "uniprot:A0A8I3MK78", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CACNG7" ], "parents" : [ 10288655 ], "children" : [ ] }, { "dbId" : 10254349, "stId" : "R-CFA-418304", "displayName" : "ATP2B4 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "diagramIds" : [ 53280 ], "identifier" : "A0A8I3PEN3", "standardIdentifier" : "uniprot:A0A8I3PEN3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ATP2B4" ], "parents" : [ 10289401, 10254351 ], "children" : [ ] }, { "dbId" : 10288655, "stId" : "R-CFA-9699115", "displayName" : "CACNG4,6,7,8 [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 49646, "parents" : [ 10288663 ], "children" : [ 10254145, 10247236, 10288649, 10288653 ] }, { "dbId" : 10254351, "stId" : "R-CFA-418306", "displayName" : "ATP2B1-4 [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 49646, "diagramIds" : [ 53277 ], "parents" : [ ], "children" : [ 10254337, 10254341, 10254345, 10254349 ] }, { "dbId" : 10267145, "stId" : "R-CFA-1296338", "displayName" : "KCNK13 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3NNF9", "standardIdentifier" : "uniprot:A0A8I3NNF9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNK13" ], "parents" : [ 10288791 ], "children" : [ ] }, { "dbId" : 10288649, "stId" : "R-CFA-210406", "displayName" : "CACNG6 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3RTB9", "standardIdentifier" : "uniprot:A0A8I3RTB9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CACNG6" ], "parents" : [ 10288655 ], "children" : [ ] }, { "dbId" : 10254345, "stId" : "R-CFA-418300", "displayName" : "ATP2B3 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3PJ46", "standardIdentifier" : "uniprot:A0A8I3PJ46", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ATP2B3" ], "parents" : [ 10254351 ], "children" : [ ] }, { "dbId" : 10288645, "stId" : "R-CFA-9699114", "displayName" : "CACNB1,2 [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 49646, "parents" : [ 10288663 ], "children" : [ 10288643, 10288641 ] }, { "dbId" : 10254341, "stId" : "R-CFA-418303", "displayName" : "ATP2B2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3RVD4", "standardIdentifier" : "uniprot:A0A8I3RVD4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ATP2B2" ], "parents" : [ 10254351 ], "children" : [ ] }, { "dbId" : 10288641, "stId" : "R-CFA-532197", "displayName" : "CACNB1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3NMX5", "standardIdentifier" : "uniprot:A0A8I3NMX5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CACNB1" ], "parents" : [ 10288645 ], "children" : [ ] }, { "dbId" : 10254337, "stId" : "R-CFA-418301", "displayName" : "ATP2B1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3NYA8", "standardIdentifier" : "uniprot:A0A8I3NYA8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ATP2B1" ], "parents" : [ 10254351 ], "children" : [ ] }, { "dbId" : 10288643, "stId" : "R-CFA-532200", "displayName" : "CACNB2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3NPX9", "standardIdentifier" : "uniprot:A0A8I3NPX9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CACNB2" ], "parents" : [ 10288645 ], "children" : [ ] }, { "dbId" : 10267196, "stId" : "R-CFA-1299256", "displayName" : "TRESK homodimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288803 ], "children" : [ 10267194 ] }, { "dbId" : 10288700, "stId" : "R-CFA-977537", "displayName" : "KCNE2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3PME7", "standardIdentifier" : "uniprot:A0A8I3PME7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNE2" ], "parents" : [ 10288714 ], "children" : [ ] }, { "dbId" : 10288696, "stId" : "R-CFA-977542", "displayName" : "KCNE1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3PYI8", "standardIdentifier" : "uniprot:A0A8I3PYI8", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10288714 ], "children" : [ ] }, { "dbId" : 10267194, "stId" : "R-CFA-1296330", "displayName" : "KCNK18 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3Q644", "standardIdentifier" : "uniprot:A0A8I3Q644", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNK18" ], "parents" : [ 10267196 ], "children" : [ ] }, { "dbId" : 29356, "stId" : "R-ALL-29356", "displayName" : "H2O [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53250, 53319 ], "identifier" : "15377", "standardIdentifier" : "chebi:15377", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10288689, "stId" : "R-CFA-5577126", "displayName" : "KCND tetramer:KCNIP tetramer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53225 ], "parents" : [ ], "children" : [ 10288687, 10288671 ] }, { "dbId" : 10288685, "stId" : "R-CFA-5577094", "displayName" : "KCNIP1-4 [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 49646, "parents" : [ 10288687 ], "children" : [ 10288675, 10288679, 10288683 ] }, { "dbId" : 10267183, "stId" : "R-CFA-1296317", "displayName" : "KCNK9 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3NAZ8", "standardIdentifier" : "uniprot:A0A8I3NAZ8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNK9" ], "parents" : [ 10288801 ], "children" : [ ] }, { "dbId" : 10288687, "stId" : "R-CFA-5577207", "displayName" : "KCNIP tetramer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288689 ], "children" : [ 10288685 ] }, { "dbId" : 10267177, "stId" : "R-CFA-1296326", "displayName" : "KCNK3 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3S6X0", "standardIdentifier" : "uniprot:A0A8I3S6X0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNK3" ], "parents" : [ 10267179 ], "children" : [ ] }, { "dbId" : 10267179, "stId" : "R-CFA-1299268", "displayName" : "TASK 1 homomer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288803 ], "children" : [ 10267177 ] }, { "dbId" : 10288683, "stId" : "R-CFA-5577152", "displayName" : "KCNIP4 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3NNY5", "standardIdentifier" : "uniprot:A0A8I3NNY5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNIP4" ], "parents" : [ 10288685 ], "children" : [ ] }, { "dbId" : 29370, "stId" : "R-ALL-29370", "displayName" : "ADP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53254 ], "identifier" : "456216", "standardIdentifier" : "chebi:456216", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10288679, "stId" : "R-CFA-5577157", "displayName" : "KCNIP2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3S569", "standardIdentifier" : "uniprot:A0A8I3S569", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNIP2" ], "parents" : [ 10288685 ], "children" : [ ] }, { "dbId" : 10254375, "stId" : "R-CFA-419293", "displayName" : "NOS1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "diagramIds" : [ 53279 ], "identifier" : "A0A8I3PT17", "standardIdentifier" : "uniprot:A0A8I3PT17", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NOS1" ], "parents" : [ 10289401 ], "children" : [ ] }, { "dbId" : 10267168, "stId" : "R-CFA-1299250", "displayName" : "TWIK2 dimers [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288803 ], "children" : [ 10267166 ] }, { "dbId" : 29372, "stId" : "R-ALL-29372", "displayName" : "Pi [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53253 ], "identifier" : "43474", "standardIdentifier" : "chebi:43474", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10288675, "stId" : "R-CFA-5577236", "displayName" : "KCNIP1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3N263", "standardIdentifier" : "uniprot:A0A8I3N263", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNIP1" ], "parents" : [ 10288685 ], "children" : [ ] }, { "dbId" : 9684057, "stId" : "R-ALL-9684057", "displayName" : "acetyldigitoxin [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "6794", "standardIdentifier" : "iuphar.ligand:6794", "chebiIdentifier" : "chebi:53773", "parents" : [ 9684063 ], "children" : [ ] }, { "dbId" : 10318417, "stId" : "R-CFA-9613836", "displayName" : "KCNA5 tetramer:Class III (KCNA5) antiarrhythmics [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53308 ], "parents" : [ ], "children" : [ 9613840, 10318415 ] }, { "dbId" : 9684063, "stId" : "R-ALL-9684063", "displayName" : "cardiac glycosides [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 0, "diagramIds" : [ 53302 ], "parents" : [ 10262448 ], "children" : [ 9684077, 9684057, 9684074, 9684069, 9684082 ] }, { "dbId" : 10296400, "stId" : "R-CFA-5692430", "displayName" : "NPR2:NPPC [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53300 ], "parents" : [ ], "children" : [ 10296394, 10296398 ] }, { "dbId" : 109265, "stId" : "R-ALL-109265", "displayName" : "Zn2+ [plasma membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "29105", "standardIdentifier" : "chebi:29105", "referenceType" : "ReferenceMolecule", "parents" : [ 10274584 ], "children" : [ ] }, { "dbId" : 10288716, "stId" : "R-CFA-5577121", "displayName" : "KCNH2:KCNE [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53229 ], "parents" : [ 10288719 ], "children" : [ 10288714, 10266920 ] }, { "dbId" : 10318415, "stId" : "R-CFA-9613577", "displayName" : "KCNA5 tetramer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53306 ], "parents" : [ 10318417 ], "children" : [ 10266896 ] }, { "dbId" : 10296398, "stId" : "R-CFA-5692448", "displayName" : "NPR2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "diagramIds" : [ 53299 ], "identifier" : "A0A8I3N816", "standardIdentifier" : "uniprot:A0A8I3N816", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NPR2" ], "parents" : [ 10296400 ], "children" : [ ] }, { "dbId" : 10288719, "stId" : "R-CFA-9613243", "displayName" : "Class III antiarrhythmics:KCNH2:KCNE [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53230 ], "parents" : [ ], "children" : [ 9613262, 10288716 ] }, { "dbId" : 10288712, "stId" : "R-CFA-977533", "displayName" : "KCNE4 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3P4I4", "standardIdentifier" : "uniprot:A0A8I3P4I4", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10288714 ], "children" : [ ] }, { "dbId" : 10267209, "stId" : "R-CFA-1296333", "displayName" : "KCNK17 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3NUY1", "standardIdentifier" : "uniprot:A0A8I3NUY1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNK17" ], "parents" : [ 10267211 ], "children" : [ ] }, { "dbId" : 10288714, "stId" : "R-CFA-5577223", "displayName" : "KCNEs [plasma membrane]", "schemaClass" : "CandidateSet", "speciesId" : 49646, "parents" : [ 10288716 ], "children" : [ 10288696, 10288700, 10288704, 10288708, 10288712 ] }, { "dbId" : 10248266, "stId" : "R-CFA-265551", "displayName" : "CACNA1C [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3QY31", "standardIdentifier" : "uniprot:A0A8I3QY31", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10288663 ], "children" : [ ] }, { "dbId" : 10267211, "stId" : "R-CFA-1299272", "displayName" : "TALK 2 homomer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288803 ], "children" : [ 10267209 ] }, { "dbId" : 10296394, "stId" : "R-CFA-5490332", "displayName" : "NPPC [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "diagramIds" : [ 53298 ], "identifier" : "A0A8I3Q3C1", "standardIdentifier" : "uniprot:A0A8I3Q3C1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NPPC" ], "parents" : [ 10296400 ], "children" : [ ] }, { "dbId" : 10288708, "stId" : "R-CFA-977536", "displayName" : "KCNE3 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MYQ7", "standardIdentifier" : "uniprot:A0A8I3MYQ7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNE3" ], "parents" : [ 10288714 ], "children" : [ ] }, { "dbId" : 10247236, "stId" : "R-CFA-210417", "displayName" : "CACNG4 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3Q178", "standardIdentifier" : "uniprot:A0A8I3Q178", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CACNG4" ], "parents" : [ 10288655 ], "children" : [ ] }, { "dbId" : 10267205, "stId" : "R-CFA-1299275", "displayName" : "TALK1 homomer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10288803 ], "children" : [ 10267203 ] }, { "dbId" : 10228807, "stId" : "R-CFA-9016707", "displayName" : "CALM1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "diagramIds" : [ 53265, 53238 ], "identifier" : "A0A8I3PNY6", "standardIdentifier" : "uniprot:A0A8I3PNY6", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10234116 ], "children" : [ ] }, { "dbId" : 10288704, "stId" : "R-CFA-977539", "displayName" : "KCNE5 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3PKK9", "standardIdentifier" : "uniprot:A0A8I3PKK9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNE5" ], "parents" : [ 10288714 ], "children" : [ ] }, { "dbId" : 10267203, "stId" : "R-CFA-1296335", "displayName" : "KCNK16 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3NSP8", "standardIdentifier" : "uniprot:A0A8I3NSP8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNK16" ], "parents" : [ 10267205 ], "children" : [ ] }, { "dbId" : 10288764, "stId" : "R-CFA-5578797", "displayName" : "NPPA [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "diagramIds" : [ 53292 ], "identifier" : "P07499", "standardIdentifier" : "uniprot:P07499", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NPPA" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 9684082, "stId" : "R-ALL-9684082", "displayName" : "ouabain [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "4826", "standardIdentifier" : "iuphar.ligand:4826", "chebiIdentifier" : "chebi:472805", "parents" : [ 9684063 ], "children" : [ ] }, { "dbId" : 10288766, "stId" : "R-CFA-5578799", "displayName" : "NPPA [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "diagramIds" : [ 53291 ], "identifier" : "P07499", "standardIdentifier" : "uniprot:P07499", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NPPA" ], "parents" : [ 10298570 ], "children" : [ ] }, { "dbId" : 10288760, "stId" : "R-CFA-5578791", "displayName" : "NPPA [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "diagramIds" : [ 53290 ], "identifier" : "P07499", "standardIdentifier" : "uniprot:P07499", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NPPA" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 10288762, "stId" : "R-CFA-5578794", "displayName" : "NPPA [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "diagramIds" : [ 53289 ], "identifier" : "P07499", "standardIdentifier" : "uniprot:P07499", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NPPA" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 10288758, "stId" : "R-CFA-976950", "displayName" : "NPPA [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "diagramIds" : [ 53288 ], "identifier" : "P07499", "standardIdentifier" : "uniprot:P07499", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NPPA" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 9727588, "stId" : "R-ALL-9727588", "displayName" : "sacubitrilat [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "diagramIds" : [ 53315 ], "identifier" : "7858", "standardIdentifier" : "iuphar.ligand:7858", "parents" : [ 10321809 ], "children" : [ ] }, { "dbId" : 9684069, "stId" : "R-ALL-9684069", "displayName" : "deslanoside [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "6806", "standardIdentifier" : "iuphar.ligand:6806", "chebiIdentifier" : "chebi:31468", "parents" : [ 9684063 ], "children" : [ ] }, { "dbId" : 9727597, "stId" : "R-ALL-9727597", "displayName" : "sacubitril [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "diagramIds" : [ 53318 ], "identifier" : "7857", "standardIdentifier" : "iuphar.ligand:7857", "chebiIdentifier" : "chebi:134714", "parents" : [ ], "children" : [ ] }, { "dbId" : 9684074, "stId" : "R-ALL-9684074", "displayName" : "digoxin [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "4726", "standardIdentifier" : "iuphar.ligand:4726", "chebiIdentifier" : "chebi:4551", "parents" : [ 9684063 ], "children" : [ ] }, { "dbId" : 9684077, "stId" : "R-ALL-9684077", "displayName" : "digitoxin [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "6782", "standardIdentifier" : "iuphar.ligand:6782", "chebiIdentifier" : "chebi:28544", "parents" : [ 9684063 ], "children" : [ ] }, { "dbId" : 10248291, "stId" : "R-CFA-265561", "displayName" : "KCNJ11 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3NVA4", "standardIdentifier" : "uniprot:A0A8I3NVA4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNJ11" ], "parents" : [ 10293455 ], "children" : [ ] }, { "dbId" : 10262429, "stId" : "R-CFA-2752084", "displayName" : "FXYD3 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MQA1", "standardIdentifier" : "uniprot:A0A8I3MQA1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "FXYD3" ], "parents" : [ 10262443 ], "children" : [ ] }, { "dbId" : 10265502, "stId" : "R-CFA-1168370", "displayName" : "STIM1 Dimer [endoplasmic reticulum membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10276083 ], "children" : [ 10265498 ] }, { "dbId" : 111875, "stId" : "R-ALL-111875", "displayName" : "Ca2+ [endoplasmic reticulum lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53242 ], "identifier" : "29108", "standardIdentifier" : "chebi:29108", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10262425, "stId" : "R-CFA-936805", "displayName" : "FXYD2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MK29", "standardIdentifier" : "uniprot:A0A8I3MK29", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "FXYD2" ], "parents" : [ 10262443 ], "children" : [ ] }, { "dbId" : 10265498, "stId" : "R-CFA-434675", "displayName" : "STIM1 [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3RWM0", "standardIdentifier" : "uniprot:A0A8I3RWM0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "STIM1" ], "parents" : [ 10265502 ], "children" : [ ] }, { "dbId" : 10262421, "stId" : "R-CFA-2752086", "displayName" : "FXYD1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MRH3", "standardIdentifier" : "uniprot:A0A8I3MRH3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "FXYD1" ], "parents" : [ 10262443 ], "children" : [ ] }, { "dbId" : 10321809, "stId" : "R-CFA-9727599", "displayName" : "MME:Zn2+:sacubitrilat [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53316 ], "parents" : [ ], "children" : [ 10274584, 9727588 ] }, { "dbId" : 10255760, "stId" : "R-CFA-432792", "displayName" : "CAMK2 heteromer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10255762 ], "children" : [ 10255758, 10255756 ] }, { "dbId" : 10262417, "stId" : "R-CFA-936820", "displayName" : "ATP1B [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 49646, "parents" : [ 10262445 ], "children" : [ 10262407, 10262411, 10262415 ] }, { "dbId" : 10255762, "stId" : "R-CFA-444601", "displayName" : "CAMK2 heteromer:CALM:4xCa2+ [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53246 ], "parents" : [ ], "children" : [ 10255760, 10234116 ] }, { "dbId" : 10255756, "stId" : "R-CFA-432795", "displayName" : "p-CAMK2A, p-CAMK2B [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 49646, "parents" : [ 10255760 ], "children" : [ 10255754, 10255752 ] }, { "dbId" : 10321804, "stId" : "R-CFA-9727569", "displayName" : "CES1 trimer [lipid droplet]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53321 ], "parents" : [ ], "children" : [ 10321802 ] }, { "dbId" : 10255758, "stId" : "R-CFA-432797", "displayName" : "phospho-CAMK2G [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3RWC7", "standardIdentifier" : "uniprot:A0A8I3RWC7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CAMK2G" ], "parents" : [ 10255760 ], "children" : [ ] }, { "dbId" : 10262415, "stId" : "R-CFA-375073", "displayName" : "ATP1B3 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3SBE1", "standardIdentifier" : "uniprot:A0A8I3SBE1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ATP1B3" ], "parents" : [ 10262417 ], "children" : [ ] }, { "dbId" : 10255752, "stId" : "R-CFA-432796", "displayName" : "phospho-CAMK2A [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3NIS8", "standardIdentifier" : "uniprot:A0A8I3NIS8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CAMK2A" ], "parents" : [ 10255756 ], "children" : [ ] }, { "dbId" : 2855229, "stId" : "R-ALL-2855229", "displayName" : "Ca2+ [sarcoplasmic reticulum lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53260 ], "identifier" : "29108", "standardIdentifier" : "chebi:29108", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10255754, "stId" : "R-CFA-432791", "displayName" : "phospho-CAMK2B [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3NMP2", "standardIdentifier" : "uniprot:A0A8I3NMP2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CAMK2B" ], "parents" : [ 10255756 ], "children" : [ ] }, { "dbId" : 10321802, "stId" : "R-CFA-9727618", "displayName" : "CES5A [lipid droplet]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3RP60", "standardIdentifier" : "uniprot:A0A8I3RP60", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CES5A" ], "parents" : [ 10321804 ], "children" : [ ] }, { "dbId" : 10262411, "stId" : "R-CFA-375075", "displayName" : "ATP1B2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3PQA5", "standardIdentifier" : "uniprot:A0A8I3PQA5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ATP1B2" ], "parents" : [ 10262417 ], "children" : [ ] }, { "dbId" : 10255748, "stId" : "R-CFA-5578813", "displayName" : "phospho-PLN [sarcoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "P61012", "standardIdentifier" : "uniprot:P61012", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PLN" ], "parents" : [ 10255750 ], "children" : [ ] }, { "dbId" : 10255750, "stId" : "R-CFA-5578810", "displayName" : "p-S16-PLN pentamer [sarcoplasmic reticulum membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53245 ], "parents" : [ ], "children" : [ 10255748 ] }, { "dbId" : 10262407, "stId" : "R-CFA-375071", "displayName" : "ATP1B1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MFG9", "standardIdentifier" : "uniprot:A0A8I3MFG9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ATP1B1" ], "parents" : [ 10262417 ], "children" : [ ] }, { "dbId" : 10255745, "stId" : "R-CFA-5578811", "displayName" : "PLN pentamer [sarcoplasmic reticulum membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53247 ], "parents" : [ ], "children" : [ 10255743 ] }, { "dbId" : 10262401, "stId" : "R-CFA-936803", "displayName" : "ATP1A3 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MID3", "standardIdentifier" : "uniprot:A0A8I3MID3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ATP1A3" ], "parents" : [ 10262403 ], "children" : [ ] }, { "dbId" : 10262403, "stId" : "R-CFA-936779", "displayName" : "ATP1A [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 49646, "parents" : [ 10262445 ], "children" : [ 10262401, 10262393, 10262397 ] }, { "dbId" : 141090, "stId" : "R-ALL-141090", "displayName" : "Ca2+ [platelet dense tubular network membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "29108", "standardIdentifier" : "chebi:29108", "referenceType" : "ReferenceMolecule", "parents" : [ 10235066 ], "children" : [ ] }, { "dbId" : 10280892, "stId" : "R-CFA-2855225", "displayName" : "CASQ2 [sarcoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3Q4A3", "standardIdentifier" : "uniprot:A0A8I3Q4A3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CASQ2" ], "parents" : [ 10280894 ], "children" : [ ] }, { "dbId" : 74016, "stId" : "R-ALL-74016", "displayName" : "Ca2+ [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53233, 53219, 53268, 53272, 53241, 53275, 53263 ], "identifier" : "29108", "standardIdentifier" : "chebi:29108", "referenceType" : "ReferenceMolecule", "parents" : [ 10234116 ], "children" : [ ] }, { "dbId" : 9700789, "stId" : "R-ALL-9700789", "displayName" : "aranidipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "11744", "standardIdentifier" : "iuphar.ligand:11744", "chebiIdentifier" : "chebi:31232", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 9700790, "stId" : "R-ALL-9700790", "displayName" : "nilvadipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "10160", "standardIdentifier" : "iuphar.ligand:10160", "chebiIdentifier" : "chebi:31911", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 10280894, "stId" : "R-CFA-2855188", "displayName" : "CASQ2 polymer [sarcoplasmic reticulum lumen]", "schemaClass" : "Polymer", "speciesId" : 49646, "parents" : [ 10280896 ], "children" : [ 10280892 ] }, { "dbId" : 10280888, "stId" : "R-CFA-2855198", "displayName" : "CASQ1 polymer [sarcoplasmic reticulum lumen]", "schemaClass" : "Polymer", "speciesId" : 49646, "parents" : [ 10280896 ], "children" : [ 10280886 ] }, { "dbId" : 9700787, "stId" : "R-ALL-9700787", "displayName" : "azelnidipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "65948", "standardIdentifier" : "pubchem.compound:65948", "chebiIdentifier" : "chebi:31247", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 10280886, "stId" : "R-CFA-2855174", "displayName" : "CASQ1 [sarcoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3SCS7", "standardIdentifier" : "uniprot:A0A8I3SCS7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CASQ1" ], "parents" : [ 10280888 ], "children" : [ ] }, { "dbId" : 10262448, "stId" : "R-CFA-9684072", "displayName" : "ATP1A:ATP1B:FXYD:cardiac glycosides [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53258 ], "parents" : [ ], "children" : [ 9684063, 10262445 ] }, { "dbId" : 9700794, "stId" : "R-ALL-9700794", "displayName" : "lercanidipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "65866", "standardIdentifier" : "pubchem.compound:65866", "chebiIdentifier" : "chebi:135930", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 10262445, "stId" : "R-CFA-936770", "displayName" : "ATP1A:ATP1B:FXYD [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53257 ], "parents" : [ 10262448 ], "children" : [ 10262403, 10262417, 10262443 ] }, { "dbId" : 9700775, "stId" : "R-ALL-9700775", "displayName" : "efonidipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "2519", "standardIdentifier" : "iuphar.ligand:2519", "chebiIdentifier" : "chebi:146219", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 10262441, "stId" : "R-CFA-2752082", "displayName" : "FXYD7 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MM26", "standardIdentifier" : "uniprot:A0A8I3MM26", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "FXYD7" ], "parents" : [ 10262443 ], "children" : [ ] }, { "dbId" : 10267051, "stId" : "R-CFA-1296325", "displayName" : "KCNK4 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3Q3Z0", "standardIdentifier" : "uniprot:A0A8I3Q3Z0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNK4" ], "parents" : [ 10288793 ], "children" : [ ] }, { "dbId" : 10262443, "stId" : "R-CFA-2752106", "displayName" : "FXYDs [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 49646, "parents" : [ 10262445 ], "children" : [ 10262433, 10262437, 10262421, 10262441, 10262425, 10262429 ] }, { "dbId" : 9700781, "stId" : "R-ALL-9700781", "displayName" : "lacidipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "11740", "standardIdentifier" : "iuphar.ligand:11740", "chebiIdentifier" : "chebi:135737", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 10262437, "stId" : "R-CFA-2752104", "displayName" : "FXYD6 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3RSR2", "standardIdentifier" : "uniprot:A0A8I3RSR2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "FXYD6" ], "parents" : [ 10262443 ], "children" : [ ] }, { "dbId" : 10267047, "stId" : "R-CFA-1296342", "displayName" : "KCNK10 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3N317", "standardIdentifier" : "uniprot:A0A8I3N317", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNK10" ], "parents" : [ 10288783 ], "children" : [ ] }, { "dbId" : 9613230, "stId" : "R-ALL-9613230", "displayName" : "E-4031 [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "2605", "standardIdentifier" : "iuphar.ligand:2605", "chebiIdentifier" : "chebi:34732", "parents" : [ 9613262 ], "children" : [ ] }, { "dbId" : 9700776, "stId" : "R-ALL-9700776", "displayName" : "barnidipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "443869", "standardIdentifier" : "pubchem.compound:443869", "chebiIdentifier" : "chebi:135793", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 9700777, "stId" : "R-ALL-9700777", "displayName" : "levamlodipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "9822750", "standardIdentifier" : "pubchem.compound:9822750", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 10262433, "stId" : "R-CFA-2752081", "displayName" : "FXYD4 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3PX80", "standardIdentifier" : "uniprot:A0A8I3PX80", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "FXYD4" ], "parents" : [ 10262443 ], "children" : [ ] }, { "dbId" : 9700779, "stId" : "R-ALL-9700779", "displayName" : "dexniguldipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "463", "standardIdentifier" : "iuphar.ligand:463", "chebiIdentifier" : "chebi:103932", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 9613266, "stId" : "R-ALL-9613266", "displayName" : "ibutilide [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "7200", "standardIdentifier" : "iuphar.ligand:7200", "chebiIdentifier" : "chebi:5856", "parents" : [ 9613262 ], "children" : [ ] }, { "dbId" : 10280924, "stId" : "R-CFA-5490321", "displayName" : "FKBP1B [sarcoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3PCD4", "standardIdentifier" : "uniprot:A0A8I3PCD4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "FKBP1B" ], "parents" : [ 10280926 ], "children" : [ ] }, { "dbId" : 10280926, "stId" : "R-CFA-5578817", "displayName" : "FKBP1B tetramer [sarcoplasmic reticulum membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10280932 ], "children" : [ 10280924 ] }, { "dbId" : 10280920, "stId" : "R-CFA-2855215", "displayName" : "TRDN [sarcoplasmic reticulum lumen]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3M9N6", "standardIdentifier" : "uniprot:A0A8I3M9N6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TRDN" ], "parents" : [ 10280932 ], "children" : [ ] }, { "dbId" : 10280916, "stId" : "R-CFA-2855176", "displayName" : "RYR tetramers [sarcoplasmic reticulum membrane]", "schemaClass" : "DefinedSet", "speciesId" : 49646, "parents" : [ 10280932 ], "children" : [ 10280914, 10280902, 10280908 ] }, { "dbId" : 10280912, "stId" : "R-CFA-937282", "displayName" : "RYR3 [sarcoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3Q8P6", "standardIdentifier" : "uniprot:A0A8I3Q8P6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RYR3" ], "parents" : [ 10280914 ], "children" : [ ] }, { "dbId" : 10280914, "stId" : "R-CFA-2855220", "displayName" : "RYR3 tetramer [sarcoplasmic reticulum membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10280916 ], "children" : [ 10280912 ] }, { "dbId" : 10280908, "stId" : "R-CFA-2855184", "displayName" : "RYR2 tetramer [sarcoplasmic reticulum membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10280916 ], "children" : [ 10280906 ] }, { "dbId" : 9613254, "stId" : "R-ALL-9613254", "displayName" : "dofetilide [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "2604", "standardIdentifier" : "iuphar.ligand:2604", "chebiIdentifier" : "chebi:4681", "parents" : [ 9613262 ], "children" : [ ] }, { "dbId" : 10280906, "stId" : "R-CFA-937283", "displayName" : "RYR2 [sarcoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MT21", "standardIdentifier" : "uniprot:A0A8I3MT21", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RYR2" ], "parents" : [ 10280908 ], "children" : [ ] }, { "dbId" : 10280900, "stId" : "R-CFA-937287", "displayName" : "RYR1 [sarcoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MXS3", "standardIdentifier" : "uniprot:A0A8I3MXS3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RYR1" ], "parents" : [ 10280902 ], "children" : [ ] }, { "dbId" : 10280902, "stId" : "R-CFA-2855211", "displayName" : "RYR1 tetramer [sarcoplasmic reticulum membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10280916 ], "children" : [ 10280900 ] }, { "dbId" : 9613262, "stId" : "R-ALL-9613262", "displayName" : "Class III antiarrhythmics [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 0, "diagramIds" : [ 53310 ], "parents" : [ 10288719 ], "children" : [ 9613230, 9613254, 9613266 ] }, { "dbId" : 10280896, "stId" : "R-CFA-2855210", "displayName" : "CASQ polymer [sarcoplasmic reticulum lumen]", "schemaClass" : "DefinedSet", "speciesId" : 49646, "parents" : [ 10280932 ], "children" : [ 10280888, 10280894 ] }, { "dbId" : 10255349, "stId" : "R-CFA-5490313", "displayName" : "SRI [sarcoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "diagramIds" : [ 53237 ], "identifier" : "A0A8I3RY81", "standardIdentifier" : "uniprot:A0A8I3RY81", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SRI" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 10255344, "stId" : "R-CFA-425675", "displayName" : "SLC8A1,2,3 [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 49646, "diagramIds" : [ 53236 ], "parents" : [ ], "children" : [ 10255338, 10255342 ] }, { "dbId" : 10255342, "stId" : "R-CFA-425658", "displayName" : "SLC8A3 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3RTF4", "standardIdentifier" : "uniprot:A0A8I3RTF4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SLC8A3" ], "parents" : [ 10255344 ], "children" : [ ] }, { "dbId" : 10280937, "stId" : "R-CFA-2684963", "displayName" : "CLIC2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "diagramIds" : [ 53264 ], "identifier" : "A0A8I3P560", "standardIdentifier" : "uniprot:A0A8I3P560", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CLIC2" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 10255338, "stId" : "R-CFA-425656", "displayName" : "SLC8A2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MTJ5", "standardIdentifier" : "uniprot:A0A8I3MTJ5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SLC8A2" ], "parents" : [ 10255344 ], "children" : [ ] }, { "dbId" : 10280932, "stId" : "R-CFA-2855167", "displayName" : "RYR tetramer:FKBP1B tetramer:CASQ polymer:TRDN:junctin [sarcoplasmic reticulum membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53261 ], "parents" : [ ], "children" : [ 10280930, 10280896, 10280916, 10280920, 10280926 ] }, { "dbId" : 10280930, "stId" : "R-CFA-5490331", "displayName" : "ASPH [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3Q886", "standardIdentifier" : "uniprot:A0A8I3Q886", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ASPH" ], "parents" : [ 10280932 ], "children" : [ ] }, { "dbId" : 156540, "stId" : "R-ALL-156540", "displayName" : "H+ [endoplasmic reticulum lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53240 ], "identifier" : "15378", "standardIdentifier" : "chebi:15378", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 74113, "stId" : "R-ALL-74113", "displayName" : "Na+ [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53232, 53255 ], "identifier" : "29101", "standardIdentifier" : "chebi:29101", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 74112, "stId" : "R-ALL-74112", "displayName" : "Ca2+ [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53218, 53267, 53235, 53276 ], "identifier" : "29108", "standardIdentifier" : "chebi:29108", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10274584, "stId" : "R-CFA-9727395", "displayName" : "MME:Zn2+ [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 49646, "diagramIds" : [ 53314 ], "parents" : [ 10321809 ], "children" : [ 10274582, 109265 ] }, { "dbId" : 10274582, "stId" : "R-CFA-2022342", "displayName" : "MME [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "F5C3N2", "standardIdentifier" : "uniprot:F5C3N2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MME" ], "parents" : [ 10274584 ], "children" : [ ] }, { "dbId" : 9614105, "stId" : "R-ALL-9614105", "displayName" : "clevidipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "7468", "standardIdentifier" : "iuphar.ligand:7468", "chebiIdentifier" : "chebi:135738", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 10266896, "stId" : "R-CFA-977472", "displayName" : "KCNA5 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3SCN1", "standardIdentifier" : "uniprot:A0A8I3SCN1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNA5" ], "parents" : [ 10318415 ], "children" : [ ] }, { "dbId" : 9614110, "stId" : "R-ALL-9614110", "displayName" : "diltiazem [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "2298", "standardIdentifier" : "iuphar.ligand:2298", "chebiIdentifier" : "chebi:101278", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 9614108, "stId" : "R-ALL-9614108", "displayName" : "Class IV antihypertensives [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 0, "diagramIds" : [ 53304 ], "parents" : [ 10288666 ], "children" : [ 9700779, 9614124, 9700777, 9700776, 9614120, 9700781, 9700685, 9614123, 9614116, 9700775, 9614112, 9700699, 9614109, 9700794, 9614079, 9614110, 9614105, 9700787, 9614132, 9614135, 9700790, 9700789, 9614131 ] }, { "dbId" : 74126, "stId" : "R-ALL-74126", "displayName" : "K+ [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53283, 53252, 53224, 53212, 53228 ], "identifier" : "29103", "standardIdentifier" : "chebi:29103", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 9614109, "stId" : "R-ALL-9614109", "displayName" : "nimodipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "2523", "standardIdentifier" : "iuphar.ligand:2523", "chebiIdentifier" : "chebi:7575", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 10234116, "stId" : "R-CFA-74294", "displayName" : "CALM1:4xCa2+ [cytosol]", "schemaClass" : "Complex", "speciesId" : 49646, "parents" : [ 10255762 ], "children" : [ 10228807, 74016 ] }, { "dbId" : 9614131, "stId" : "R-ALL-9614131", "displayName" : "nisoldipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "2524", "standardIdentifier" : "iuphar.ligand:2524", "chebiIdentifier" : "chebi:7577", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 9614135, "stId" : "R-ALL-9614135", "displayName" : "verapamil [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "2406", "standardIdentifier" : "iuphar.ligand:2406", "chebiIdentifier" : "chebi:77733", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 9614132, "stId" : "R-ALL-9614132", "displayName" : "nitrendipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "2334", "standardIdentifier" : "iuphar.ligand:2334", "chebiIdentifier" : "chebi:7582", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 9614112, "stId" : "R-ALL-9614112", "displayName" : "isradipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "4488", "standardIdentifier" : "iuphar.ligand:4488", "chebiIdentifier" : "chebi:6073", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 10266920, "stId" : "R-CFA-977529", "displayName" : "KCNH2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "Q9TSZ3", "standardIdentifier" : "uniprot:Q9TSZ3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCNH2" ], "parents" : [ 10288716 ], "children" : [ ] }, { "dbId" : 9614116, "stId" : "R-ALL-9614116", "displayName" : "nifedipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "2514", "standardIdentifier" : "iuphar.ligand:2514", "chebiIdentifier" : "chebi:7565", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 9614123, "stId" : "R-ALL-9614123", "displayName" : "felodipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "4190", "standardIdentifier" : "iuphar.ligand:4190", "chebiIdentifier" : "chebi:585948", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 113592, "stId" : "R-ALL-113592", "displayName" : "ATP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53249, 53262 ], "identifier" : "30616", "standardIdentifier" : "chebi:30616", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 9614120, "stId" : "R-ALL-9614120", "displayName" : "cilnidipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "7767", "standardIdentifier" : "iuphar.ligand:7767", "chebiIdentifier" : "chebi:31399", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 9614124, "stId" : "R-ALL-9614124", "displayName" : "nicardipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "2559", "standardIdentifier" : "iuphar.ligand:2559", "chebiIdentifier" : "chebi:180905", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 10266972, "stId" : "R-CFA-977451", "displayName" : "KCND3 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3N7D5", "standardIdentifier" : "uniprot:A0A8I3N7D5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCND3" ], "parents" : [ 10266974 ], "children" : [ ] }, { "dbId" : 10266974, "stId" : "R-CFA-1296101", "displayName" : "KCND1,2,3 [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 49646, "parents" : [ 10288671 ], "children" : [ 10266964, 10266968, 10266972 ] }, { "dbId" : 10266968, "stId" : "R-CFA-977453", "displayName" : "KCND2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3RXY5", "standardIdentifier" : "uniprot:A0A8I3RXY5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCND2" ], "parents" : [ 10266974 ], "children" : [ ] }, { "dbId" : 9691477, "stId" : "R-ALL-9691477", "displayName" : "nicorandil [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "diagramIds" : [ 53312 ], "identifier" : "2411", "standardIdentifier" : "iuphar.ligand:2411", "chebiIdentifier" : "chebi:31905", "parents" : [ 10293458 ], "children" : [ ] }, { "dbId" : 83910, "stId" : "R-ALL-83910", "displayName" : "Na+ [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53234, 53251 ], "identifier" : "29101", "standardIdentifier" : "chebi:29101", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10266964, "stId" : "R-CFA-977455", "displayName" : "KCND1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3Q626", "standardIdentifier" : "uniprot:A0A8I3Q626", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KCND1" ], "parents" : [ 10266974 ], "children" : [ ] }, { "dbId" : 9700699, "stId" : "R-ALL-9700699", "displayName" : "manidipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "11739", "standardIdentifier" : "iuphar.ligand:11739", "chebiIdentifier" : "chebi:135849", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 9700685, "stId" : "R-ALL-9700685", "displayName" : "benidipine [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "10159", "standardIdentifier" : "iuphar.ligand:10159", "chebiIdentifier" : "chebi:135806", "parents" : [ 9614108 ], "children" : [ ] }, { "dbId" : 70106, "stId" : "R-ALL-70106", "displayName" : "H+ [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53243 ], "identifier" : "15378", "standardIdentifier" : "chebi:15378", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10254145, "stId" : "R-CFA-210486", "displayName" : "CACNG8 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3N7S8", "standardIdentifier" : "uniprot:A0A8I3N7S8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CACNG8" ], "parents" : [ 10288655 ], "children" : [ ] }, { "dbId" : 10262397, "stId" : "R-CFA-936827", "displayName" : "ATP1A2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3QAS6", "standardIdentifier" : "uniprot:A0A8I3QAS6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ATP1A2" ], "parents" : [ 10262403 ], "children" : [ ] }, { "dbId" : 10255743, "stId" : "R-CFA-5490319", "displayName" : "PLN [sarcoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "P61012", "standardIdentifier" : "uniprot:P61012", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PLN" ], "parents" : [ 10255745 ], "children" : [ ] }, { "dbId" : 10255736, "stId" : "R-CFA-391965", "displayName" : "ATP2A3 [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3S0A4", "standardIdentifier" : "uniprot:A0A8I3S0A4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ATP2A3" ], "parents" : [ 10255738 ], "children" : [ ] }, { "dbId" : 10262393, "stId" : "R-CFA-936850", "displayName" : "ATP1A1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3SBK9", "standardIdentifier" : "uniprot:A0A8I3SBK9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ATP1A1" ], "parents" : [ 10262403 ], "children" : [ ] }, { "dbId" : 10255738, "stId" : "R-CFA-418312", "displayName" : "ATP2A1-3 [endoplasmic reticulum membrane]", "schemaClass" : "DefinedSet", "speciesId" : 49646, "diagramIds" : [ 53244 ], "parents" : [ ], "children" : [ 10255734, 10255732, 10255736 ] }, { "dbId" : 10255732, "stId" : "R-CFA-391961", "displayName" : "ATP2A1 [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "A0A8I3MJQ7", "standardIdentifier" : "uniprot:A0A8I3MJQ7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ATP2A1" ], "parents" : [ 10255738 ], "children" : [ ] }, { "dbId" : 10255734, "stId" : "R-CFA-391962", "displayName" : "ATP2A2 [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 49646, "identifier" : "O46674", "standardIdentifier" : "uniprot:O46674", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10255738 ], "children" : [ ] }, { "dbId" : 30203, "stId" : "R-ALL-30203", "displayName" : "EtOH [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 53320 ], "identifier" : "16236", "standardIdentifier" : "chebi:16236", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] } ], "edges" : [ { "dbId" : 10288668, "stId" : "R-CFA-5577213", "displayName" : "LTCC multimer transports Ca2+ from extracellular region to cytosol", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 74112 ], "outputs" : [ 74016 ], "catalysts" : [ 10288663 ], "efs" : [ ], "inhibitors" : [ 10288666 ], "diagramIds" : [ 53217 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10235069, "stId" : "R-CFA-139854", "displayName" : "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 139827 ], "outputs" : [ 74016 ], "catalysts" : [ 10235066 ], "efs" : [ ], "diagramIds" : [ 53270 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10266872, "stId" : "R-CFA-1296046", "displayName" : "KCNJs transport K+ from the extracellular region to cytosol", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 74126 ], "outputs" : [ 29804 ], "catalysts" : [ 10266869 ], "efs" : [ ], "diagramIds" : [ 53211 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10276088, "stId" : "R-CFA-2089943", "displayName" : "TRPC1 translocates calcium from the extracellular region to the cytosol", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 74112 ], "outputs" : [ 74016 ], "catalysts" : [ 10276083 ], "efs" : [ ], "diagramIds" : [ 53266 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10289403, "stId" : "R-CFA-5617178", "displayName" : "ATP2B4 binds to NOS1, inhibiting it", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 10254375, 10254349 ], "outputs" : [ 10289401 ], "efs" : [ ], "diagramIds" : [ 53278 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10320346, "stId" : "R-CFA-9691566", "displayName" : "KCNJ11:ABCC9 binds nicorandil", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 9691477, 10293455 ], "outputs" : [ 10293458 ], "efs" : [ ], "diagramIds" : [ 53311 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10288692, "stId" : "R-CFA-5577234", "displayName" : "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 29804 ], "outputs" : [ 74126 ], "catalysts" : [ 10288689 ], "efs" : [ ], "diagramIds" : [ 53222 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10318421, "stId" : "R-CFA-9614031", "displayName" : "Class IV antihypertensives bind LTCC multimer", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 9614108, 10288663 ], "outputs" : [ 10288666 ], "efs" : [ ], "diagramIds" : [ 53303 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10255764, "stId" : "R-CFA-427910", "displayName" : "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 156540, 74016 ], "outputs" : [ 70106, 111875 ], "catalysts" : [ 10255738 ], "efs" : [ ], "inhibitors" : [ 10255745 ], "activators" : [ 10255762, 10255750, 10255349 ], "diagramIds" : [ 53239 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10293460, "stId" : "R-CFA-5678261", "displayName" : "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 74126 ], "outputs" : [ 29804 ], "catalysts" : [ 10293455 ], "efs" : [ ], "activators" : [ 10293458 ], "diagramIds" : [ 53282 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10255351, "stId" : "R-CFA-425661", "displayName" : "SLC8A1,2,3 exchange 3Na+ for Ca2+", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 74016, 74113 ], "outputs" : [ 83910, 74112 ], "catalysts" : [ 10255344 ], "efs" : [ ], "inhibitors" : [ 10228807 ], "activators" : [ 10255349 ], "diagramIds" : [ 53231 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10288721, "stId" : "R-CFA-5577237", "displayName" : "KCNH2:KCNE transport K+ from cytosol to extracellular region", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 29804 ], "outputs" : [ 74126 ], "catalysts" : [ 10288716 ], "efs" : [ ], "inhibitors" : [ 10288719 ], "diagramIds" : [ 53226 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10321811, "stId" : "R-CFA-9727607", "displayName" : "MME:Zn2+ binds sacubitrilat", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10321807 ], "inputs" : [ 10274584, 9727588 ], "outputs" : [ 10321809 ], "efs" : [ ], "diagramIds" : [ 53313 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10318419, "stId" : "R-CFA-9613570", "displayName" : "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 10318415, 9613840 ], "outputs" : [ 10318417 ], "efs" : [ ], "diagramIds" : [ 53305 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10262450, "stId" : "R-CFA-936897", "displayName" : "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 74126, 29356, 113592, 83910 ], "outputs" : [ 29372, 29804, 29370, 74113 ], "catalysts" : [ 10262445 ], "efs" : [ ], "inhibitors" : [ 10262448 ], "diagramIds" : [ 53248 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10254354, "stId" : "R-CFA-418309", "displayName" : "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 74016 ], "outputs" : [ 74112 ], "catalysts" : [ 10254351 ], "efs" : [ ], "diagramIds" : [ 53274 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10296402, "stId" : "R-CFA-5692408", "displayName" : "NPR2 binds NPPC", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 10296394, 10296398 ], "outputs" : [ 10296400 ], "efs" : [ ], "diagramIds" : [ 53297 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10298572, "stId" : "R-CFA-6784598", "displayName" : "NPPA(124-151) binds NPR1", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 10298568, 10288766 ], "outputs" : [ 10298570 ], "efs" : [ ], "diagramIds" : [ 53294 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10321807, "stId" : "R-CFA-9727567", "displayName" : "CES1 hydrolyses sacubitril to sacubitrilat", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 10321811 ], "inputs" : [ 29356, 9727597 ], "outputs" : [ 30203, 9727588 ], "catalysts" : [ 10321804 ], "efs" : [ ], "diagramIds" : [ 53317 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10318409, "stId" : "R-CFA-9613264", "displayName" : "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 9613262, 10288716 ], "outputs" : [ 10288719 ], "efs" : [ ], "diagramIds" : [ 53309 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10280939, "stId" : "R-CFA-2855020", "displayName" : "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 2855229 ], "outputs" : [ 74016 ], "catalysts" : [ 10280932 ], "efs" : [ ], "inhibitors" : [ 10228807, 10280937 ], "activators" : [ 113592, 74016, 10255349 ], "diagramIds" : [ 53259 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10288773, "stId" : "R-CFA-5578783", "displayName" : "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 10288758 ], "outputs" : [ 10288762, 10288760, 10288766, 10288764 ], "catalysts" : [ 10288770 ], "efs" : [ ], "diagramIds" : [ 53287 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10288806, "stId" : "R-CFA-5578910", "displayName" : "KCNK dimers transport K+ from cytosol to extracellular region", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 29804 ], "outputs" : [ 74126 ], "catalysts" : [ 10288803 ], "efs" : [ ], "diagramIds" : [ 53215 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10320231, "stId" : "R-CFA-9684068", "displayName" : "ATP1A:ATP1B:FXYD binds cardiac glycosides", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 9684063, 10262445 ], "outputs" : [ 10262448 ], "efs" : [ ], "diagramIds" : [ 53301 ], "entityFunctionalStatus" : [ ] } ], "subpathways" : [ { "dbId" : 10331163, "stId" : "R-CFA-5578768", "displayName" : "Physiological factors", "events" : [ 10298572, 10321807, 10288773, 10321811, 10296402 ] }, { "dbId" : 10331155, "stId" : "R-CFA-5576893", "displayName" : "Phase 2 - plateau phase", "events" : [ 10288668, 10318421 ] }, { "dbId" : 10331153, "stId" : "R-CFA-5576892", "displayName" : "Phase 0 - rapid depolarisation", "events" : [ 10288668 ] }, { "dbId" : 10330701, "stId" : "R-CFA-5576886", "displayName" : "Phase 4 - resting membrane potential", "events" : [ 10266872, 10288806 ] }, { "dbId" : 10331157, "stId" : "R-CFA-5576894", "displayName" : "Phase 1 - inactivation of fast Na+ channels", "events" : [ 10288692 ] }, { "dbId" : 10331159, "stId" : "R-CFA-5576890", "displayName" : "Phase 3 - rapid repolarisation", "events" : [ 10318409, 10288721, 10318419 ] }, { "dbId" : 10329139, "stId" : "R-CFA-5578775", "displayName" : "Ion homeostasis", "events" : [ 10235069, 10276088, 10289403, 10280939, 10320346, 10255764, 10293460, 10320231, 10255351, 10262450, 10254354 ] } ] }