{ "dbId" : 10329783, "stableId" : "R-CFA-196807", "displayName" : "Nicotinate metabolism", "nodes" : [ { "id" : 102913, "reactomeId" : 10328703, "displayName" : "Tryptophan catabolism", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 168, "y" : 304 }, "minX" : 110, "maxX" : 226, "minY" : 272, "maxY" : 337, "prop" : { "x" : 110, "y" : 272, "width" : 116, "height" : 65 }, "textPosition" : { "x" : 122, "y" : 283 }, "connectors" : [ ] }, { "id" : 102763, "reactomeId" : 197238, "displayName" : "QUIN", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 484, "y" : 303 }, "minX" : 461, "maxX" : 508, "minY" : 287, "maxY" : 379, "prop" : { "x" : 461, "y" : 288, "width" : 46, "height" : 30 }, "textPosition" : { "x" : 465, "y" : 292 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 502, "y" : 293 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 502, "y" : 293 } } }, "connectors" : [ { "edgeId" : 102762, "type" : "INPUT", "segments" : [ { "from" : { "x" : 483, "y" : 321 }, "to" : { "x" : 483, "y" : 379 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102765, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 533, "y" : 346 }, "minX" : 483, "maxX" : 552, "minY" : 330, "maxY" : 379, "prop" : { "x" : 515, "y" : 331, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 519, "y" : 335 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 546, "y" : 336 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 546, "y" : 336 } } }, "connectors" : [ { "edgeId" : 102762, "type" : "INPUT", "segments" : [ { "from" : { "x" : 512, "y" : 357 }, "to" : { "x" : 483, "y" : 379 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 491, "y" : 362 }, "b" : { "x" : 503, "y" : 374 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 497, "y" : 368 } } } } ], "trivial" : true }, { "id" : 102764, "reactomeId" : 73566, "displayName" : "PRPP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 438, "y" : 346 }, "minX" : 415, "maxX" : 483, "minY" : 330, "maxY" : 379, "prop" : { "x" : 415, "y" : 331, "width" : 46, "height" : 30 }, "textPosition" : { "x" : 418, "y" : 335 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 456, "y" : 336 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 456, "y" : 336 } } }, "connectors" : [ { "edgeId" : 102762, "type" : "INPUT", "segments" : [ { "from" : { "x" : 458, "y" : 364 }, "to" : { "x" : 483, "y" : 379 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102767, "reactomeId" : 111294, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 537, "y" : 472 }, "minX" : 484, "maxX" : 555, "minY" : 455, "maxY" : 487, "prop" : { "x" : 520, "y" : 457, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 523, "y" : 461 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 549, "y" : 462 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 549, "y" : 462 } } }, "connectors" : [ { "edgeId" : 102762, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 517, "y" : 466 }, "to" : { "x" : 484, "y" : 455 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 509, "y" : 468 }, "b" : { "x" : 517, "y" : 466 }, "c" : { "x" : 512, "y" : 460 }, "type" : "ARROW", "centre" : { "x" : 512, "y" : 460 } } } ] }, { "id" : 102766, "reactomeId" : 113528, "displayName" : "CO2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 436, "y" : 474 }, "minX" : 415, "maxX" : 484, "minY" : 455, "maxY" : 489, "prop" : { "x" : 415, "y" : 459, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 419, "y" : 463 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 452, "y" : 464 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 452, "y" : 464 } } }, "connectors" : [ { "edgeId" : 102762, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 460, "y" : 465 }, "to" : { "x" : 484, "y" : 455 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 465, "y" : 459 }, "b" : { "x" : 460, "y" : 465 }, "c" : { "x" : 468, "y" : 466 }, "type" : "ARROW", "centre" : { "x" : 468, "y" : 466 } } } ], "trivial" : true }, { "id" : 102769, "reactomeId" : 10243180, "displayName" : "QPRT", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 423, "y" : 417 }, "minX" : 403, "maxX" : 476, "minY" : 400, "maxY" : 428, "prop" : { "x" : 403, "y" : 406, "width" : 41, "height" : 22 }, "textPosition" : { "x" : 403, "y" : 406 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 444, "y" : 406 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 444, "y" : 406 } } }, "connectors" : [ { "edgeId" : 102762, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 447, "y" : 417 }, "to" : { "x" : 468, "y" : 417 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 472, "y" : 417 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 472, "y" : 417 } } } ] }, { "id" : 102768, "reactomeId" : 8869359, "displayName" : "NAMN", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 486, "y" : 517 }, "minX" : 254, "maxX" : 705, "minY" : 455, "maxY" : 598, "prop" : { "x" : 460, "y" : 502, "width" : 53, "height" : 31 }, "textPosition" : { "x" : 464, "y" : 507 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 508, "y" : 507 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 508, "y" : 507 } } }, "connectors" : [ { "edgeId" : 102762, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 485, "y" : 499 }, "to" : { "x" : 484, "y" : 455 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 481, "y" : 492 }, "b" : { "x" : 485, "y" : 499 }, "c" : { "x" : 489, "y" : 492 }, "type" : "ARROW", "centre" : { "x" : 489, "y" : 492 } } }, { "edgeId" : 102861, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 457, "y" : 513 }, "to" : { "x" : 254, "y" : 483 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 450, "y" : 516 }, "b" : { "x" : 457, "y" : 513 }, "c" : { "x" : 451, "y" : 508 }, "type" : "ARROW", "centre" : { "x" : 451, "y" : 508 } } }, { "edgeId" : 102873, "type" : "INPUT", "segments" : [ { "from" : { "x" : 485, "y" : 536 }, "to" : { "x" : 485, "y" : 598 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 102808, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 516, "y" : 516 }, "to" : { "x" : 705, "y" : 514 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 523, "y" : 512 }, "b" : { "x" : 516, "y" : 516 }, "c" : { "x" : 523, "y" : 520 }, "type" : "ARROW", "centre" : { "x" : 523, "y" : 520 } } } ] }, { "id" : 102771, "reactomeId" : 200492, "displayName" : "NAMN", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1848, "y" : 490 }, "minX" : 1822, "maxX" : 1908, "minY" : 474, "maxY" : 505, "prop" : { "x" : 1822, "y" : 475, "width" : 53, "height" : 30 }, "textPosition" : { "x" : 1826, "y" : 479 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1870, "y" : 480 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1870, "y" : 480 } } }, "connectors" : [ { "edgeId" : 102770, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1878, "y" : 490 }, "to" : { "x" : 1908, "y" : 490 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102773, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1852, "y" : 529 }, "minX" : 1832, "maxX" : 1908, "minY" : 490, "maxY" : 545, "prop" : { "x" : 1832, "y" : 514, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1836, "y" : 519 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1867, "y" : 519 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1867, "y" : 519 } } }, "connectors" : [ { "edgeId" : 102770, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1875, "y" : 515 }, "to" : { "x" : 1908, "y" : 490 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102772, "reactomeId" : 9668967, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1909, "y" : 532 }, "minX" : 1891, "maxX" : 1928, "minY" : 490, "maxY" : 548, "prop" : { "x" : 1891, "y" : 517, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 1895, "y" : 522 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1922, "y" : 522 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1922, "y" : 522 } } }, "connectors" : [ { "edgeId" : 102770, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1908, "y" : 514 }, "to" : { "x" : 1908, "y" : 490 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 102775, "reactomeId" : 113541, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2022, "y" : 535 }, "minX" : 1987, "maxX" : 2040, "minY" : 490, "maxY" : 551, "prop" : { "x" : 2005, "y" : 520, "width" : 34, "height" : 31 }, "textPosition" : { "x" : 2008, "y" : 525 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2034, "y" : 525 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2034, "y" : 525 } } }, "connectors" : [ { "edgeId" : 102770, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2009, "y" : 517 }, "to" : { "x" : 1987, "y" : 490 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2002, "y" : 514 }, "b" : { "x" : 2009, "y" : 517 }, "c" : { "x" : 2008, "y" : 509 }, "type" : "ARROW", "centre" : { "x" : 2008, "y" : 509 } } } ] }, { "id" : 102774, "reactomeId" : 200499, "displayName" : "NAAD", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2046, "y" : 491 }, "minX" : 1987, "maxX" : 2073, "minY" : 475, "maxY" : 506, "prop" : { "x" : 2021, "y" : 476, "width" : 51, "height" : 30 }, "textPosition" : { "x" : 2025, "y" : 480 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2067, "y" : 481 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2067, "y" : 481 } } }, "connectors" : [ { "edgeId" : 102770, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2018, "y" : 490 }, "to" : { "x" : 1987, "y" : 490 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2011, "y" : 494 }, "b" : { "x" : 2018, "y" : 490 }, "c" : { "x" : 2011, "y" : 486 }, "type" : "ARROW", "centre" : { "x" : 2011, "y" : 486 } } } ] }, { "id" : 102776, "reactomeId" : 10244342, "displayName" : "6xNMNAT1:6xZn2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1948, "y" : 440 }, "minX" : 1885, "maxX" : 2018, "minY" : 423, "maxY" : 482, "prop" : { "x" : 1885, "y" : 429, "width" : 127, "height" : 22 }, "textPosition" : { "x" : 1885, "y" : 430 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2012, "y" : 429 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2012, "y" : 429 } } }, "connectors" : [ { "edgeId" : 102770, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1947, "y" : 454 }, "to" : { "x" : 1947, "y" : 474 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1947, "y" : 478 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1947, "y" : 478 } } } ] }, { "id" : 102779, "reactomeId" : 113593, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1633, "y" : 460 }, "minX" : 1613, "maxX" : 1681, "minY" : 444, "maxY" : 489, "prop" : { "x" : 1613, "y" : 445, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1617, "y" : 450 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1648, "y" : 450 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1648, "y" : 450 } } }, "connectors" : [ { "edgeId" : 102777, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1656, "y" : 472 }, "to" : { "x" : 1681, "y" : 489 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102778, "reactomeId" : 8938083, "displayName" : "NAMN", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1680, "y" : 424 }, "minX" : 1654, "maxX" : 1708, "minY" : 408, "maxY" : 489, "prop" : { "x" : 1654, "y" : 409, "width" : 53, "height" : 30 }, "textPosition" : { "x" : 1658, "y" : 413 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1702, "y" : 414 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1702, "y" : 414 } } }, "connectors" : [ { "edgeId" : 102777, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1680, "y" : 442 }, "to" : { "x" : 1681, "y" : 489 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102781, "reactomeId" : 159450, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1631, "y" : 597 }, "minX" : 1614, "maxX" : 1680, "minY" : 576, "maxY" : 613, "prop" : { "x" : 1614, "y" : 582, "width" : 34, "height" : 31 }, "textPosition" : { "x" : 1617, "y" : 587 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1643, "y" : 587 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1643, "y" : 587 } } }, "connectors" : [ { "edgeId" : 102777, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1651, "y" : 589 }, "to" : { "x" : 1680, "y" : 576 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1656, "y" : 583 }, "b" : { "x" : 1651, "y" : 589 }, "c" : { "x" : 1659, "y" : 590 }, "type" : "ARROW", "centre" : { "x" : 1659, "y" : 590 } } } ] }, { "id" : 102780, "reactomeId" : 113529, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1721, "y" : 465 }, "minX" : 1681, "maxX" : 1740, "minY" : 449, "maxY" : 489, "prop" : { "x" : 1703, "y" : 450, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 1707, "y" : 454 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1734, "y" : 455 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1734, "y" : 455 } } }, "connectors" : [ { "edgeId" : 102777, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1700, "y" : 475 }, "to" : { "x" : 1681, "y" : 489 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 102783, "reactomeId" : 10244333, "displayName" : "4xNMNAT3:4xMg2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1595, "y" : 531 }, "minX" : 1553, "maxX" : 1671, "minY" : 507, "maxY" : 550, "prop" : { "x" : 1553, "y" : 513, "width" : 84, "height" : 37 }, "textPosition" : { "x" : 1556, "y" : 515 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1637, "y" : 513 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1637, "y" : 513 } } }, "connectors" : [ { "edgeId" : 102777, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1640, "y" : 531 }, "to" : { "x" : 1663, "y" : 531 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1667, "y" : 531 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1667, "y" : 531 } } } ] }, { "id" : 102782, "reactomeId" : 8938090, "displayName" : "NAAD", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1679, "y" : 647 }, "minX" : 1654, "maxX" : 1706, "minY" : 576, "maxY" : 662, "prop" : { "x" : 1654, "y" : 632, "width" : 51, "height" : 30 }, "textPosition" : { "x" : 1658, "y" : 636 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1700, "y" : 637 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1700, "y" : 637 } } }, "connectors" : [ { "edgeId" : 102777, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1679, "y" : 629 }, "to" : { "x" : 1680, "y" : 576 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1675, "y" : 622 }, "b" : { "x" : 1679, "y" : 629 }, "c" : { "x" : 1683, "y" : 622 }, "type" : "ARROW", "centre" : { "x" : 1683, "y" : 622 } } } ] }, { "id" : 102785, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 424, "y" : 744 }, "minX" : 403, "maxX" : 485, "minY" : 728, "maxY" : 801, "prop" : { "x" : 403, "y" : 729, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 407, "y" : 733 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 441, "y" : 734 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 441, "y" : 734 } } }, "connectors" : [ { "edgeId" : 102784, "type" : "INPUT", "segments" : [ { "from" : { "x" : 440, "y" : 762 }, "to" : { "x" : 485, "y" : 801 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 102787, "reactomeId" : 197256, "displayName" : "NAAD", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 485, "y" : 726 }, "minX" : 460, "maxX" : 512, "minY" : 668, "maxY" : 801, "prop" : { "x" : 460, "y" : 711, "width" : 51, "height" : 30 }, "textPosition" : { "x" : 464, "y" : 715 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 506, "y" : 716 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 506, "y" : 716 } } }, "connectors" : [ { "edgeId" : 102784, "type" : "INPUT", "segments" : [ { "from" : { "x" : 485, "y" : 744 }, "to" : { "x" : 485, "y" : 801 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 102873, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 484, "y" : 708 }, "to" : { "x" : 484, "y" : 668 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 480, "y" : 701 }, "b" : { "x" : 484, "y" : 708 }, "c" : { "x" : 488, "y" : 701 }, "type" : "ARROW", "centre" : { "x" : 488, "y" : 701 } } } ] }, { "id" : 102786, "reactomeId" : 29472, "displayName" : "L-Gln", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 535, "y" : 766 }, "minX" : 485, "maxX" : 561, "minY" : 750, "maxY" : 801, "prop" : { "x" : 511, "y" : 751, "width" : 49, "height" : 30 }, "textPosition" : { "x" : 516, "y" : 755 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 555, "y" : 756 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 555, "y" : 756 } } }, "connectors" : [ { "edgeId" : 102784, "type" : "INPUT", "segments" : [ { "from" : { "x" : 513, "y" : 784 }, "to" : { "x" : 485, "y" : 801 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102789, "reactomeId" : 29360, "displayName" : "NAD+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 487, "y" : 968 }, "minX" : 403, "maxX" : 517, "minY" : 883, "maxY" : 1038, "prop" : { "x" : 458, "y" : 951, "width" : 58, "height" : 34 }, "textPosition" : { "x" : 465, "y" : 957 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 511, "y" : 956 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 511, "y" : 956 } } }, "connectors" : [ { "edgeId" : 102784, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 486, "y" : 948 }, "to" : { "x" : 485, "y" : 883 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 482, "y" : 941 }, "b" : { "x" : 486, "y" : 948 }, "c" : { "x" : 490, "y" : 941 }, "type" : "ARROW", "centre" : { "x" : 490, "y" : 941 } } }, { "edgeId" : 102795, "type" : "INPUT", "segments" : [ { "from" : { "x" : 486, "y" : 988 }, "to" : { "x" : 485, "y" : 1038 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 102836, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 455, "y" : 966 }, "to" : { "x" : 403, "y" : 965 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 448, "y" : 970 }, "b" : { "x" : 455, "y" : 966 }, "c" : { "x" : 448, "y" : 962 }, "type" : "ARROW", "centre" : { "x" : 448, "y" : 962 } } } ] }, { "id" : 102788, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 424, "y" : 785 }, "minX" : 404, "maxX" : 485, "minY" : 769, "maxY" : 801, "prop" : { "x" : 404, "y" : 770, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 408, "y" : 774 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 439, "y" : 775 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 439, "y" : 775 } } }, "connectors" : [ { "edgeId" : 102784, "type" : "INPUT", "segments" : [ { "from" : { "x" : 447, "y" : 790 }, "to" : { "x" : 485, "y" : 801 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102791, "reactomeId" : 76577, "displayName" : "AMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 435, "y" : 917 }, "minX" : 414, "maxX" : 485, "minY" : 883, "maxY" : 932, "prop" : { "x" : 414, "y" : 902, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 418, "y" : 906 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 451, "y" : 907 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 451, "y" : 907 } } }, "connectors" : [ { "edgeId" : 102784, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 459, "y" : 902 }, "to" : { "x" : 485, "y" : 883 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 462, "y" : 895 }, "b" : { "x" : 459, "y" : 902 }, "c" : { "x" : 467, "y" : 901 }, "type" : "ARROW", "centre" : { "x" : 467, "y" : 901 } } } ] }, { "id" : 102790, "reactomeId" : 29404, "displayName" : "L-Glu", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 538, "y" : 878 }, "minX" : 485, "maxX" : 564, "minY" : 862, "maxY" : 893, "prop" : { "x" : 514, "y" : 863, "width" : 49, "height" : 30 }, "textPosition" : { "x" : 519, "y" : 867 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 558, "y" : 868 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 558, "y" : 868 } } }, "connectors" : [ { "edgeId" : 102784, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 511, "y" : 880 }, "to" : { "x" : 485, "y" : 883 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 505, "y" : 885 }, "b" : { "x" : 511, "y" : 880 }, "c" : { "x" : 504, "y" : 877 }, "type" : "ARROW", "centre" : { "x" : 504, "y" : 877 } } } ] }, { "id" : 102793, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 534, "y" : 920 }, "minX" : 485, "maxX" : 553, "minY" : 883, "maxY" : 935, "prop" : { "x" : 516, "y" : 905, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 520, "y" : 909 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 547, "y" : 910 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 547, "y" : 910 } } }, "connectors" : [ { "edgeId" : 102784, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 513, "y" : 906 }, "to" : { "x" : 485, "y" : 883 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 505, "y" : 905 }, "b" : { "x" : 513, "y" : 906 }, "c" : { "x" : 510, "y" : 899 }, "type" : "ARROW", "centre" : { "x" : 510, "y" : 899 } } } ], "trivial" : true }, { "id" : 102792, "reactomeId" : 111294, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 433, "y" : 873 }, "minX" : 416, "maxX" : 485, "minY" : 857, "maxY" : 888, "prop" : { "x" : 416, "y" : 858, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 419, "y" : 862 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 445, "y" : 863 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 445, "y" : 863 } } }, "connectors" : [ { "edgeId" : 102784, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 453, "y" : 876 }, "to" : { "x" : 485, "y" : 883 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 461, "y" : 874 }, "b" : { "x" : 453, "y" : 876 }, "c" : { "x" : 459, "y" : 881 }, "type" : "ARROW", "centre" : { "x" : 459, "y" : 881 } } } ] }, { "id" : 102794, "reactomeId" : 10243189, "displayName" : "NADSYN1 hexamer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 584, "y" : 836 }, "minX" : 493, "maxX" : 650, "minY" : 819, "maxY" : 847, "prop" : { "x" : 524, "y" : 825, "width" : 120, "height" : 22 }, "textPosition" : { "x" : 549, "y" : 812 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 644, "y" : 825 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 644, "y" : 825 } } }, "connectors" : [ { "edgeId" : 102784, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 521, "y" : 837 }, "to" : { "x" : 501, "y" : 838 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 497, "y" : 838 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 497, "y" : 838 } } } ] }, { "id" : 102797, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 531, "y" : 1110 }, "minX" : 486, "maxX" : 553, "minY" : 1094, "maxY" : 1126, "prop" : { "x" : 511, "y" : 1095, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 515, "y" : 1100 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 547, "y" : 1100 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 547, "y" : 1100 } } }, "connectors" : [ { "edgeId" : 102795, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 508, "y" : 1102 }, "to" : { "x" : 486, "y" : 1094 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 500, "y" : 1103 }, "b" : { "x" : 508, "y" : 1102 }, "c" : { "x" : 503, "y" : 1096 }, "type" : "ARROW", "centre" : { "x" : 503, "y" : 1096 } } } ] }, { "id" : 102796, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 531, "y" : 1020 }, "minX" : 485, "maxX" : 552, "minY" : 1004, "maxY" : 1038, "prop" : { "x" : 511, "y" : 1005, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 515, "y" : 1009 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 546, "y" : 1010 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 546, "y" : 1010 } } }, "connectors" : [ { "edgeId" : 102795, "type" : "INPUT", "segments" : [ { "from" : { "x" : 508, "y" : 1027 }, "to" : { "x" : 485, "y" : 1038 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102799, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 432, "y" : 1122 }, "minX" : 414, "maxX" : 486, "minY" : 1094, "maxY" : 1137, "prop" : { "x" : 414, "y" : 1107, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 418, "y" : 1111 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 445, "y" : 1112 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 445, "y" : 1112 } } }, "connectors" : [ { "edgeId" : 102795, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 453, "y" : 1112 }, "to" : { "x" : 486, "y" : 1094 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 457, "y" : 1105 }, "b" : { "x" : 453, "y" : 1112 }, "c" : { "x" : 461, "y" : 1112 }, "type" : "ARROW", "centre" : { "x" : 461, "y" : 1112 } } } ], "trivial" : true }, { "id" : 102798, "reactomeId" : 29366, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 488, "y" : 1161 }, "minX" : 449, "maxX" : 529, "minY" : 1094, "maxY" : 1188, "prop" : { "x" : 449, "y" : 1135, "width" : 79, "height" : 53 }, "textPosition" : { "x" : 462, "y" : 1151 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 523, "y" : 1140 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 523, "y" : 1140 } } }, "connectors" : [ { "edgeId" : 102795, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 487, "y" : 1132 }, "to" : { "x" : 486, "y" : 1094 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 483, "y" : 1125 }, "b" : { "x" : 487, "y" : 1132 }, "c" : { "x" : 491, "y" : 1125 }, "type" : "ARROW", "centre" : { "x" : 491, "y" : 1125 } } } ] }, { "id" : 102800, "reactomeId" : 10243157, "displayName" : "NADK:Zn2+ tetramer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 400, "y" : 1068 }, "minX" : 359, "maxX" : 477, "minY" : 1044, "maxY" : 1086, "prop" : { "x" : 359, "y" : 1050, "width" : 83, "height" : 36 }, "textPosition" : { "x" : 359, "y" : 1051 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 442, "y" : 1050 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 442, "y" : 1050 } } }, "connectors" : [ { "edgeId" : 102795, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 445, "y" : 1067 }, "to" : { "x" : 469, "y" : 1067 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 473, "y" : 1067 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 473, "y" : 1067 } } } ] }, { "id" : 102803, "reactomeId" : 73566, "displayName" : "PRPP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1056, "y" : 864 }, "minX" : 1015, "maxX" : 1080, "minY" : 829, "maxY" : 879, "prop" : { "x" : 1033, "y" : 849, "width" : 46, "height" : 30 }, "textPosition" : { "x" : 1036, "y" : 853 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1074, "y" : 854 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1074, "y" : 854 } } }, "connectors" : [ { "edgeId" : 102801, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1038, "y" : 846 }, "to" : { "x" : 1015, "y" : 829 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102802, "reactomeId" : 197277, "displayName" : "NAM", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1015, "y" : 962 }, "minX" : 993, "maxX" : 1117, "minY" : 829, "maxY" : 977, "prop" : { "x" : 993, "y" : 947, "width" : 44, "height" : 30 }, "textPosition" : { "x" : 997, "y" : 951 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1032, "y" : 952 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1032, "y" : 952 } } }, "connectors" : [ { "edgeId" : 102801, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1015, "y" : 944 }, "to" : { "x" : 1015, "y" : 829 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 102879, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1040, "y" : 961 }, "to" : { "x" : 1117, "y" : 961 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102805, "reactomeId" : 111294, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1063, "y" : 720 }, "minX" : 1014, "maxX" : 1081, "minY" : 704, "maxY" : 739, "prop" : { "x" : 1046, "y" : 705, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 1049, "y" : 709 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1075, "y" : 710 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1075, "y" : 710 } } }, "connectors" : [ { "edgeId" : 102801, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1043, "y" : 726 }, "to" : { "x" : 1014, "y" : 739 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1038, "y" : 732 }, "b" : { "x" : 1043, "y" : 726 }, "c" : { "x" : 1035, "y" : 725 }, "type" : "ARROW", "centre" : { "x" : 1035, "y" : 725 } } } ] }, { "id" : 102804, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 983, "y" : 862 }, "minX" : 965, "maxX" : 1015, "minY" : 829, "maxY" : 877, "prop" : { "x" : 965, "y" : 847, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 969, "y" : 851 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 996, "y" : 852 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 996, "y" : 852 } } }, "connectors" : [ { "edgeId" : 102801, "type" : "INPUT", "segments" : [ { "from" : { "x" : 997, "y" : 844 }, "to" : { "x" : 1015, "y" : 829 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 102807, "reactomeId" : 10243173, "displayName" : "NAMPT", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 950, "y" : 781 }, "minX" : 925, "maxX" : 1006, "minY" : 764, "maxY" : 792, "prop" : { "x" : 925, "y" : 770, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 925, "y" : 770 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 976, "y" : 770 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 976, "y" : 770 } } }, "connectors" : [ { "edgeId" : 102801, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 979, "y" : 781 }, "to" : { "x" : 998, "y" : 781 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1002, "y" : 781 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1002, "y" : 781 } } } ] }, { "id" : 102806, "reactomeId" : 8869359, "displayName" : "NAMN", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1014, "y" : 677 }, "minX" : 988, "maxX" : 1042, "minY" : 661, "maxY" : 739, "prop" : { "x" : 988, "y" : 662, "width" : 53, "height" : 31 }, "textPosition" : { "x" : 992, "y" : 667 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1036, "y" : 667 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1036, "y" : 667 } } }, "connectors" : [ { "edgeId" : 102801, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1014, "y" : 696 }, "to" : { "x" : 1014, "y" : 739 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1018, "y" : 703 }, "b" : { "x" : 1014, "y" : 696 }, "c" : { "x" : 1010, "y" : 703 }, "type" : "ARROW", "centre" : { "x" : 1010, "y" : 703 } } } ] }, { "id" : 102809, "reactomeId" : 197230, "displayName" : "NCA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1016, "y" : 515 }, "minX" : 794, "maxX" : 1038, "minY" : 230, "maxY" : 530, "prop" : { "x" : 995, "y" : 500, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 999, "y" : 504 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1032, "y" : 505 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1032, "y" : 505 } } }, "connectors" : [ { "edgeId" : 102825, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1016, "y" : 497 }, "to" : { "x" : 1020, "y" : 230 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1012, "y" : 490 }, "b" : { "x" : 1016, "y" : 497 }, "c" : { "x" : 1020, "y" : 490 }, "type" : "ARROW", "centre" : { "x" : 1020, "y" : 490 } } }, { "edgeId" : 102808, "type" : "INPUT", "segments" : [ { "from" : { "x" : 992, "y" : 514 }, "to" : { "x" : 794, "y" : 514 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102811, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 808, "y" : 565 }, "minX" : 787, "maxX" : 831, "minY" : 514, "maxY" : 581, "prop" : { "x" : 787, "y" : 550, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 791, "y" : 555 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 825, "y" : 555 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 825, "y" : 555 } } }, "connectors" : [ { "edgeId" : 102808, "type" : "INPUT", "segments" : [ { "from" : { "x" : 803, "y" : 547 }, "to" : { "x" : 794, "y" : 514 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 102810, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 844, "y" : 478 }, "minX" : 794, "maxX" : 865, "minY" : 462, "maxY" : 514, "prop" : { "x" : 824, "y" : 463, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 828, "y" : 468 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 859, "y" : 468 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 859, "y" : 468 } } }, "connectors" : [ { "edgeId" : 102808, "type" : "INPUT", "segments" : [ { "from" : { "x" : 821, "y" : 492 }, "to" : { "x" : 794, "y" : 514 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102813, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 674, "y" : 560 }, "minX" : 661, "maxX" : 705, "minY" : 514, "maxY" : 576, "prop" : { "x" : 661, "y" : 545, "width" : 27, "height" : 31 }, "textPosition" : { "x" : 665, "y" : 550 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 683, "y" : 550 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 683, "y" : 550 } } }, "connectors" : [ { "edgeId" : 102808, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 684, "y" : 542 }, "to" : { "x" : 705, "y" : 514 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 685, "y" : 534 }, "b" : { "x" : 684, "y" : 542 }, "c" : { "x" : 691, "y" : 539 }, "type" : "ARROW", "centre" : { "x" : 691, "y" : 539 } } } ] }, { "id" : 102812, "reactomeId" : 73566, "displayName" : "PRPP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 861, "y" : 542 }, "minX" : 794, "maxX" : 885, "minY" : 514, "maxY" : 557, "prop" : { "x" : 838, "y" : 527, "width" : 46, "height" : 30 }, "textPosition" : { "x" : 841, "y" : 531 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 879, "y" : 532 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 879, "y" : 532 } } }, "connectors" : [ { "edgeId" : 102808, "type" : "INPUT", "segments" : [ { "from" : { "x" : 835, "y" : 532 }, "to" : { "x" : 794, "y" : 514 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102815, "reactomeId" : 111294, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 634, "y" : 542 }, "minX" : 617, "maxX" : 705, "minY" : 514, "maxY" : 557, "prop" : { "x" : 617, "y" : 527, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 620, "y" : 531 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 646, "y" : 532 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 646, "y" : 532 } } }, "connectors" : [ { "edgeId" : 102808, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 654, "y" : 535 }, "to" : { "x" : 705, "y" : 514 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 659, "y" : 529 }, "b" : { "x" : 654, "y" : 535 }, "c" : { "x" : 662, "y" : 536 }, "type" : "ARROW", "centre" : { "x" : 662, "y" : 536 } } } ] }, { "id" : 102814, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 670, "y" : 475 }, "minX" : 650, "maxX" : 705, "minY" : 459, "maxY" : 514, "prop" : { "x" : 650, "y" : 460, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 654, "y" : 465 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 686, "y" : 465 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 686, "y" : 465 } } }, "connectors" : [ { "edgeId" : 102808, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 683, "y" : 494 }, "to" : { "x" : 705, "y" : 514 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 691, "y" : 496 }, "b" : { "x" : 683, "y" : 494 }, "c" : { "x" : 685, "y" : 502 }, "type" : "ARROW", "centre" : { "x" : 685, "y" : 502 } } } ] }, { "id" : 102817, "reactomeId" : 29926, "displayName" : "Mg2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 746, "y" : 580 }, "minX" : 720, "maxX" : 773, "minY" : 523, "maxY" : 595, "prop" : { "x" : 720, "y" : 565, "width" : 52, "height" : 30 }, "textPosition" : { "x" : 724, "y" : 569 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 767, "y" : 570 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 767, "y" : 570 } } }, "connectors" : [ { "edgeId" : 102808, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 745, "y" : 562 }, "to" : { "x" : 745, "y" : 523 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 749, "y" : 530 }, "b" : { "x" : 745, "y" : 523 }, "c" : { "x" : 741, "y" : 530 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 741, "y" : 530 } } } ] }, { "id" : 102816, "reactomeId" : 10243148, "displayName" : "NAPRT1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 746, "y" : 442 }, "minX" : 699, "maxX" : 800, "minY" : 425, "maxY" : 506, "prop" : { "x" : 699, "y" : 431, "width" : 95, "height" : 22 }, "textPosition" : { "x" : 699, "y" : 432 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 794, "y" : 431 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 794, "y" : 431 } } }, "connectors" : [ { "edgeId" : 102808, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 745, "y" : 456 }, "to" : { "x" : 745, "y" : 498 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 745, "y" : 502 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 745, "y" : 502 } } } ] }, { "id" : 102819, "reactomeId" : 352330, "displayName" : "NAD+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1763, "y" : 177 }, "minX" : 1662, "maxX" : 1833, "minY" : 73, "maxY" : 192, "prop" : { "x" : 1737, "y" : 162, "width" : 53, "height" : 30 }, "textPosition" : { "x" : 1741, "y" : 166 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1785, "y" : 167 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1785, "y" : 167 } } }, "connectors" : [ { "edgeId" : 102848, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1793, "y" : 177 }, "to" : { "x" : 1833, "y" : 178 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 102818, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1734, "y" : 169 }, "to" : { "x" : 1662, "y" : 150 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 102859, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1734, "y" : 176 }, "to" : { "x" : 1674, "y" : 176 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 102900, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1758, "y" : 159 }, "to" : { "x" : 1734, "y" : 73 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1752, "y" : 153 }, "b" : { "x" : 1758, "y" : 159 }, "c" : { "x" : 1760, "y" : 151 }, "type" : "ARROW", "centre" : { "x" : 1760, "y" : 151 } } } ] }, { "id" : 102821, "reactomeId" : 8870343, "displayName" : "NAM", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1476, "y" : 150 }, "minX" : 1454, "maxX" : 1591, "minY" : 134, "maxY" : 176, "prop" : { "x" : 1454, "y" : 135, "width" : 44, "height" : 30 }, "textPosition" : { "x" : 1458, "y" : 139 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1493, "y" : 140 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1493, "y" : 140 } } }, "connectors" : [ { "edgeId" : 102818, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1501, "y" : 150 }, "to" : { "x" : 1591, "y" : 150 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1508, "y" : 146 }, "b" : { "x" : 1501, "y" : 150 }, "c" : { "x" : 1508, "y" : 154 }, "type" : "ARROW", "centre" : { "x" : 1508, "y" : 154 } } }, { "edgeId" : 102859, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1501, "y" : 155 }, "to" : { "x" : 1585, "y" : 176 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1509, "y" : 153 }, "b" : { "x" : 1501, "y" : 155 }, "c" : { "x" : 1507, "y" : 161 }, "type" : "ARROW", "centre" : { "x" : 1507, "y" : 161 } } } ] }, { "id" : 102820, "reactomeId" : 109276, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1716, "y" : 123 }, "minX" : 1662, "maxX" : 1739, "minY" : 107, "maxY" : 176, "prop" : { "x" : 1695, "y" : 108, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1699, "y" : 112 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1733, "y" : 113 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1733, "y" : 113 } } }, "connectors" : [ { "edgeId" : 102818, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1692, "y" : 133 }, "to" : { "x" : 1662, "y" : 150 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 102859, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1704, "y" : 141 }, "to" : { "x" : 1674, "y" : 176 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 102823, "reactomeId" : 8870342, "displayName" : "ADP-ribose", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1471, "y" : 194 }, "minX" : 1429, "maxX" : 1591, "minY" : 150, "maxY" : 209, "prop" : { "x" : 1429, "y" : 179, "width" : 84, "height" : 30 }, "textPosition" : { "x" : 1433, "y" : 183 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1508, "y" : 184 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1508, "y" : 184 } } }, "connectors" : [ { "edgeId" : 102818, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1511, "y" : 176 }, "to" : { "x" : 1591, "y" : 150 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1516, "y" : 170 }, "b" : { "x" : 1511, "y" : 176 }, "c" : { "x" : 1519, "y" : 178 }, "type" : "ARROW", "centre" : { "x" : 1519, "y" : 178 } } }, { "edgeId" : 102859, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1516, "y" : 187 }, "to" : { "x" : 1585, "y" : 176 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1522, "y" : 182 }, "b" : { "x" : 1516, "y" : 187 }, "c" : { "x" : 1523, "y" : 190 }, "type" : "ARROW", "centre" : { "x" : 1523, "y" : 190 } } } ] }, { "id" : 102822, "reactomeId" : 351626, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1520, "y" : 111 }, "minX" : 1502, "maxX" : 1618, "minY" : 73, "maxY" : 176, "prop" : { "x" : 1502, "y" : 96, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 1506, "y" : 100 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1533, "y" : 101 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1533, "y" : 101 } } }, "connectors" : [ { "edgeId" : 102818, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1541, "y" : 120 }, "to" : { "x" : 1591, "y" : 150 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1549, "y" : 120 }, "b" : { "x" : 1541, "y" : 120 }, "c" : { "x" : 1545, "y" : 127 }, "type" : "ARROW", "centre" : { "x" : 1545, "y" : 127 } } }, { "edgeId" : 102859, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1535, "y" : 129 }, "to" : { "x" : 1585, "y" : 176 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1543, "y" : 131 }, "b" : { "x" : 1535, "y" : 129 }, "c" : { "x" : 1537, "y" : 137 }, "type" : "ARROW", "centre" : { "x" : 1537, "y" : 137 } } }, { "edgeId" : 102900, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1541, "y" : 104 }, "to" : { "x" : 1618, "y" : 73 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 102824, "reactomeId" : 10311840, "displayName" : "CD38", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1684, "y" : 226 }, "minX" : 1636, "maxX" : 1711, "minY" : 156, "maxY" : 237, "prop" : { "x" : 1663, "y" : 215, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 1663, "y" : 215 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1705, "y" : 215 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1705, "y" : 215 } } }, "connectors" : [ { "edgeId" : 102818, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1676, "y" : 212 }, "to" : { "x" : 1642, "y" : 163 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1640, "y" : 160 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1640, "y" : 160 } } } ] }, { "id" : 102827, "reactomeId" : 8869604, "displayName" : "NCA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1016, "y" : 160 }, "minX" : 995, "maxX" : 1038, "minY" : 144, "maxY" : 230, "prop" : { "x" : 995, "y" : 145, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 999, "y" : 149 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1032, "y" : 150 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1032, "y" : 150 } } }, "connectors" : [ { "edgeId" : 102825, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1016, "y" : 178 }, "to" : { "x" : 1016, "y" : 230 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102826, "reactomeId" : 30034, "displayName" : "urate", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 959, "y" : 277 }, "minX" : 936, "maxX" : 1016, "minY" : 230, "maxY" : 293, "prop" : { "x" : 936, "y" : 262, "width" : 47, "height" : 31 }, "textPosition" : { "x" : 938, "y" : 267 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 978, "y" : 267 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 978, "y" : 267 } } }, "connectors" : [ { "edgeId" : 102825, "type" : "INPUT", "segments" : [ { "from" : { "x" : 977, "y" : 259 }, "to" : { "x" : 1016, "y" : 230 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102829, "reactomeId" : 10309809, "displayName" : "SLC22A13", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 932, "y" : 229 }, "minX" : 898, "maxX" : 1008, "minY" : 212, "maxY" : 240, "prop" : { "x" : 898, "y" : 218, "width" : 69, "height" : 22 }, "textPosition" : { "x" : 901, "y" : 212 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 967, "y" : 218 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 967, "y" : 218 } } }, "connectors" : [ { "edgeId" : 102825, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 970, "y" : 229 }, "to" : { "x" : 1000, "y" : 229 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1004, "y" : 229 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1004, "y" : 229 } } } ] }, { "id" : 102828, "reactomeId" : 429056, "displayName" : "urate", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1072, "y" : 184 }, "minX" : 1020, "maxX" : 1097, "minY" : 168, "maxY" : 230, "prop" : { "x" : 1049, "y" : 169, "width" : 47, "height" : 31 }, "textPosition" : { "x" : 1051, "y" : 174 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1091, "y" : 174 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1091, "y" : 174 } } }, "connectors" : [ { "edgeId" : 102825, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1054, "y" : 203 }, "to" : { "x" : 1020, "y" : 230 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1051, "y" : 210 }, "b" : { "x" : 1054, "y" : 203 }, "c" : { "x" : 1046, "y" : 204 }, "type" : "ARROW", "centre" : { "x" : 1046, "y" : 204 } } } ] }, { "id" : 102831, "reactomeId" : 429739, "displayName" : "monocarboxylates transported by SLC5A8", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1192, "y" : 159 }, "minX" : 1133, "maxX" : 1251, "minY" : 134, "maxY" : 209, "prop" : { "x" : 1133, "y" : 134, "width" : 118, "height" : 50 }, "textPosition" : { "x" : 1134, "y" : 134 }, "connectors" : [ { "edgeId" : 102830, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1191, "y" : 190 }, "to" : { "x" : 1191, "y" : 209 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102833, "reactomeId" : 429748, "displayName" : "monocarboxylates transported by SLC5A8", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1192, "y" : 354 }, "minX" : 1133, "maxX" : 1251, "minY" : 275, "maxY" : 379, "prop" : { "x" : 1133, "y" : 329, "width" : 118, "height" : 50 }, "textPosition" : { "x" : 1134, "y" : 329 }, "connectors" : [ { "edgeId" : 102830, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1191, "y" : 323 }, "to" : { "x" : 1191, "y" : 275 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1187, "y" : 316 }, "b" : { "x" : 1191, "y" : 323 }, "c" : { "x" : 1195, "y" : 316 }, "type" : "ARROW", "centre" : { "x" : 1195, "y" : 316 } } } ] }, { "id" : 102832, "reactomeId" : 74113, "displayName" : "Na+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1287, "y" : 189 }, "minX" : 1191, "maxX" : 1310, "minY" : 173, "maxY" : 209, "prop" : { "x" : 1266, "y" : 174, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1270, "y" : 178 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1304, "y" : 179 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1304, "y" : 179 } } }, "connectors" : [ { "edgeId" : 102830, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1263, "y" : 193 }, "to" : { "x" : 1191, "y" : 209 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1221, "y" : 195 }, "b" : { "x" : 1233, "y" : 207 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1227, "y" : 201 } } } } ] }, { "id" : 102835, "reactomeId" : 10256197, "displayName" : "SLC5A8", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1122, "y" : 228 }, "minX" : 1096, "maxX" : 1183, "minY" : 211, "maxY" : 239, "prop" : { "x" : 1096, "y" : 217, "width" : 53, "height" : 22 }, "textPosition" : { "x" : 1099, "y" : 211 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1149, "y" : 217 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1149, "y" : 217 } } }, "connectors" : [ { "edgeId" : 102830, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1152, "y" : 228 }, "to" : { "x" : 1175, "y" : 228 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1179, "y" : 228 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1179, "y" : 228 } } } ] }, { "id" : 102834, "reactomeId" : 83910, "displayName" : "Na+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1272, "y" : 306 }, "minX" : 1191, "maxX" : 1295, "minY" : 275, "maxY" : 321, "prop" : { "x" : 1251, "y" : 291, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1255, "y" : 295 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1289, "y" : 296 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1289, "y" : 296 } } }, "connectors" : [ { "edgeId" : 102830, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1248, "y" : 297 }, "to" : { "x" : 1191, "y" : 275 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1213, "y" : 280 }, "b" : { "x" : 1225, "y" : 292 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1219, "y" : 286 } } }, "endShape" : { "a" : { "x" : 1240, "y" : 298 }, "b" : { "x" : 1248, "y" : 297 }, "c" : { "x" : 1243, "y" : 291 }, "type" : "ARROW", "centre" : { "x" : 1243, "y" : 291 } } } ] }, { "id" : 102837, "reactomeId" : 8869353, "displayName" : "NMN", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 267, "y" : 965 }, "minX" : 179, "maxX" : 333, "minY" : 949, "maxY" : 980, "prop" : { "x" : 245, "y" : 950, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 249, "y" : 954 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 285, "y" : 955 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 285, "y" : 955 } } }, "connectors" : [ { "edgeId" : 102836, "type" : "INPUT", "segments" : [ { "from" : { "x" : 293, "y" : 964 }, "to" : { "x" : 333, "y" : 964 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 102842, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 242, "y" : 965 }, "to" : { "x" : 179, "y" : 965 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 235, "y" : 969 }, "b" : { "x" : 242, "y" : 965 }, "c" : { "x" : 235, "y" : 961 }, "type" : "ARROW", "centre" : { "x" : 235, "y" : 961 } } } ] }, { "id" : 102839, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 318, "y" : 922 }, "minX" : 300, "maxX" : 337, "minY" : 906, "maxY" : 964, "prop" : { "x" : 300, "y" : 907, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 304, "y" : 911 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 331, "y" : 912 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 331, "y" : 912 } } }, "connectors" : [ { "edgeId" : 102836, "type" : "INPUT", "segments" : [ { "from" : { "x" : 323, "y" : 940 }, "to" : { "x" : 333, "y" : 964 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 102838, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 313, "y" : 998 }, "minX" : 293, "maxX" : 334, "minY" : 964, "maxY" : 1014, "prop" : { "x" : 293, "y" : 983, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 297, "y" : 988 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 328, "y" : 988 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 328, "y" : 988 } } }, "connectors" : [ { "edgeId" : 102836, "type" : "INPUT", "segments" : [ { "from" : { "x" : 322, "y" : 980 }, "to" : { "x" : 333, "y" : 964 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102841, "reactomeId" : 10243166, "displayName" : "NMNAT2:Mg2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 375, "y" : 631 }, "minX" : 325, "maxX" : 476, "minY" : 614, "maxY" : 956, "prop" : { "x" : 325, "y" : 620, "width" : 100, "height" : 22 }, "textPosition" : { "x" : 325, "y" : 621 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 425, "y" : 620 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 425, "y" : 620 } } }, "connectors" : [ { "edgeId" : 102836, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 374, "y" : 645 }, "to" : { "x" : 374, "y" : 948 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 374, "y" : 952 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 374, "y" : 952 } } }, { "edgeId" : 102873, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 428, "y" : 631 }, "to" : { "x" : 468, "y" : 631 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 472, "y" : 631 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 472, "y" : 631 } } } ] }, { "id" : 102840, "reactomeId" : 111294, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 429, "y" : 1003 }, "minX" : 403, "maxX" : 447, "minY" : 965, "maxY" : 1018, "prop" : { "x" : 412, "y" : 988, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 415, "y" : 992 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 441, "y" : 993 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 441, "y" : 993 } } }, "connectors" : [ { "edgeId" : 102836, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 418, "y" : 985 }, "to" : { "x" : 403, "y" : 965 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 411, "y" : 982 }, "b" : { "x" : 418, "y" : 985 }, "c" : { "x" : 417, "y" : 977 }, "type" : "ARROW", "centre" : { "x" : 417, "y" : 977 } } } ] }, { "id" : 102843, "reactomeId" : 8869377, "displayName" : "NR", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 37, "y" : 953 }, "minX" : 20, "maxX" : 99, "minY" : 937, "maxY" : 968, "prop" : { "x" : 20, "y" : 938, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 24, "y" : 942 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 49, "y" : 943 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 49, "y" : 943 } } }, "connectors" : [ { "edgeId" : 102842, "type" : "INPUT", "segments" : [ { "from" : { "x" : 57, "y" : 956 }, "to" : { "x" : 99, "y" : 964 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102845, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 251, "y" : 918 }, "minX" : 179, "maxX" : 273, "minY" : 902, "maxY" : 965, "prop" : { "x" : 231, "y" : 903, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 235, "y" : 907 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 267, "y" : 908 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 267, "y" : 908 } } }, "connectors" : [ { "edgeId" : 102842, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 228, "y" : 931 }, "to" : { "x" : 179, "y" : 965 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 225, "y" : 938 }, "b" : { "x" : 228, "y" : 931 }, "c" : { "x" : 220, "y" : 932 }, "type" : "ARROW", "centre" : { "x" : 220, "y" : 932 } } } ] }, { "id" : 102844, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 40, "y" : 1006 }, "minX" : 20, "maxX" : 99, "minY" : 964, "maxY" : 1021, "prop" : { "x" : 20, "y" : 991, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 24, "y" : 995 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 55, "y" : 996 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 55, "y" : 996 } } }, "connectors" : [ { "edgeId" : 102842, "type" : "INPUT", "segments" : [ { "from" : { "x" : 63, "y" : 991 }, "to" : { "x" : 99, "y" : 964 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102847, "reactomeId" : 10309816, "displayName" : "NMRK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 142, "y" : 920 }, "minX" : 116, "maxX" : 246, "minY" : 513, "maxY" : 956, "prop" : { "x" : 116, "y" : 909, "width" : 52, "height" : 22 }, "textPosition" : { "x" : 117, "y" : 909 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 168, "y" : 909 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 168, "y" : 909 } } }, "connectors" : [ { "edgeId" : 102861, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 143, "y" : 906 }, "to" : { "x" : 193, "y" : 517 } }, { "from" : { "x" : 193, "y" : 517 }, "to" : { "x" : 238, "y" : 517 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 242, "y" : 517 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 242, "y" : 517 } } }, { "edgeId" : 102842, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 141, "y" : 934 }, "to" : { "x" : 141, "y" : 948 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 141, "y" : 952 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 141, "y" : 952 } } } ] }, { "id" : 102846, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 250, "y" : 1026 }, "minX" : 179, "maxX" : 269, "minY" : 965, "maxY" : 1041, "prop" : { "x" : 232, "y" : 1011, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 236, "y" : 1015 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 263, "y" : 1016 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 263, "y" : 1016 } } }, "connectors" : [ { "edgeId" : 102842, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 232, "y" : 1008 }, "to" : { "x" : 179, "y" : 965 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 224, "y" : 1007 }, "b" : { "x" : 232, "y" : 1008 }, "c" : { "x" : 229, "y" : 1001 }, "type" : "ARROW", "centre" : { "x" : 229, "y" : 1001 } } } ], "trivial" : true }, { "id" : 102849, "reactomeId" : 109276, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1812, "y" : 143 }, "minX" : 1791, "maxX" : 1835, "minY" : 127, "maxY" : 178, "prop" : { "x" : 1791, "y" : 128, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1795, "y" : 132 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1829, "y" : 133 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1829, "y" : 133 } } }, "connectors" : [ { "edgeId" : 102848, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1821, "y" : 161 }, "to" : { "x" : 1833, "y" : 178 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 102851, "reactomeId" : 109275, "displayName" : "AMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1946, "y" : 109 }, "minX" : 1920, "maxX" : 1968, "minY" : 93, "maxY" : 178, "prop" : { "x" : 1925, "y" : 94, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 1929, "y" : 99 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1962, "y" : 99 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1962, "y" : 99 } } }, "connectors" : [ { "edgeId" : 102848, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1940, "y" : 128 }, "to" : { "x" : 1920, "y" : 178 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1941, "y" : 136 }, "b" : { "x" : 1940, "y" : 128 }, "c" : { "x" : 1934, "y" : 133 }, "type" : "ARROW", "centre" : { "x" : 1934, "y" : 133 } } } ] }, { "id" : 102850, "reactomeId" : 8940067, "displayName" : "NMN", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2002, "y" : 178 }, "minX" : 1920, "maxX" : 2075, "minY" : 162, "maxY" : 193, "prop" : { "x" : 1980, "y" : 163, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 1984, "y" : 167 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2020, "y" : 168 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2020, "y" : 168 } } }, "connectors" : [ { "edgeId" : 102848, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1977, "y" : 178 }, "to" : { "x" : 1920, "y" : 178 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1970, "y" : 182 }, "b" : { "x" : 1977, "y" : 178 }, "c" : { "x" : 1970, "y" : 174 }, "type" : "ARROW", "centre" : { "x" : 1970, "y" : 174 } } }, { "edgeId" : 102855, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2028, "y" : 178 }, "to" : { "x" : 2075, "y" : 178 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102853, "reactomeId" : 351626, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1890, "y" : 129 }, "minX" : 1872, "maxX" : 1920, "minY" : 113, "maxY" : 178, "prop" : { "x" : 1872, "y" : 114, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 1876, "y" : 118 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1903, "y" : 119 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1903, "y" : 119 } } }, "connectors" : [ { "edgeId" : 102848, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1899, "y" : 147 }, "to" : { "x" : 1920, "y" : 178 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1903, "y" : 156 }, "b" : { "x" : 1915, "y" : 168 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1909, "y" : 162 } } }, "endShape" : { "a" : { "x" : 1906, "y" : 150 }, "b" : { "x" : 1899, "y" : 147 }, "c" : { "x" : 1900, "y" : 155 }, "type" : "ARROW", "centre" : { "x" : 1900, "y" : 155 } } } ], "trivial" : true }, { "id" : 102852, "reactomeId" : 109277, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1986, "y" : 135 }, "minX" : 1920, "maxX" : 2004, "minY" : 119, "maxY" : 178, "prop" : { "x" : 1970, "y" : 120, "width" : 33, "height" : 30 }, "textPosition" : { "x" : 1977, "y" : 124 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1998, "y" : 125 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1998, "y" : 125 } } }, "connectors" : [ { "edgeId" : 102848, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1967, "y" : 145 }, "to" : { "x" : 1920, "y" : 178 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1964, "y" : 152 }, "b" : { "x" : 1967, "y" : 145 }, "c" : { "x" : 1959, "y" : 146 }, "type" : "ARROW", "centre" : { "x" : 1959, "y" : 146 } } } ] }, { "id" : 102854, "reactomeId" : 10232996, "displayName" : "NT5E:Zn2+ dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2003, "y" : 227 }, "minX" : 1879, "maxX" : 2098, "minY" : 178, "maxY" : 238, "prop" : { "x" : 1945, "y" : 216, "width" : 117, "height" : 22 }, "textPosition" : { "x" : 1962, "y" : 203 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2062, "y" : 216 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2062, "y" : 216 } } }, "connectors" : [ { "edgeId" : 102848, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1973, "y" : 213 }, "to" : { "x" : 1887, "y" : 183 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1883, "y" : 182 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1883, "y" : 182 } } }, { "edgeId" : 102855, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2025, "y" : 213 }, "to" : { "x" : 2090, "y" : 184 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2094, "y" : 183 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2094, "y" : 183 } } } ] }, { "id" : 102857, "reactomeId" : 8940077, "displayName" : "NR", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2211, "y" : 178 }, "minX" : 2135, "maxX" : 2232, "minY" : 163, "maxY" : 193, "prop" : { "x" : 2192, "y" : 164, "width" : 39, "height" : 29 }, "textPosition" : { "x" : 2199, "y" : 168 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2226, "y" : 169 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2226, "y" : 169 } } }, "connectors" : [ { "edgeId" : 102855, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2189, "y" : 178 }, "to" : { "x" : 2135, "y" : 178 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2182, "y" : 182 }, "b" : { "x" : 2189, "y" : 178 }, "c" : { "x" : 2182, "y" : 174 }, "type" : "ARROW", "centre" : { "x" : 2182, "y" : 174 } } } ] }, { "id" : 102856, "reactomeId" : 109276, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2039, "y" : 143 }, "minX" : 2018, "maxX" : 2075, "minY" : 127, "maxY" : 178, "prop" : { "x" : 2018, "y" : 128, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 2022, "y" : 132 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2056, "y" : 133 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2056, "y" : 133 } } }, "connectors" : [ { "edgeId" : 102855, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2054, "y" : 161 }, "to" : { "x" : 2075, "y" : 178 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 102858, "reactomeId" : 109277, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2195, "y" : 134 }, "minX" : 2135, "maxX" : 2213, "minY" : 118, "maxY" : 178, "prop" : { "x" : 2179, "y" : 119, "width" : 33, "height" : 30 }, "textPosition" : { "x" : 2186, "y" : 123 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2207, "y" : 124 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2207, "y" : 124 } } }, "connectors" : [ { "edgeId" : 102855, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2176, "y" : 146 }, "to" : { "x" : 2135, "y" : 178 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2173, "y" : 153 }, "b" : { "x" : 2176, "y" : 146 }, "c" : { "x" : 2168, "y" : 147 }, "type" : "ARROW", "centre" : { "x" : 2168, "y" : 147 } } } ] }, { "id" : 102860, "reactomeId" : 10309855, "displayName" : "BST1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1605, "y" : 225 }, "minX" : 1567, "maxX" : 1649, "minY" : 182, "maxY" : 236, "prop" : { "x" : 1567, "y" : 214, "width" : 76, "height" : 22 }, "textPosition" : { "x" : 1583, "y" : 201 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1643, "y" : 214 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1643, "y" : 214 } } }, "connectors" : [ { "edgeId" : 102859, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1611, "y" : 211 }, "to" : { "x" : 1625, "y" : 189 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1627, "y" : 186 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1627, "y" : 186 } } } ] }, { "id" : 102863, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 359, "y" : 576 }, "minX" : 253, "maxX" : 485, "minY" : 543, "maxY" : 598, "prop" : { "x" : 339, "y" : 561, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 343, "y" : 565 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 374, "y" : 566 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 374, "y" : 566 } } }, "connectors" : [ { "edgeId" : 102861, "type" : "INPUT", "segments" : [ { "from" : { "x" : 336, "y" : 569 }, "to" : { "x" : 253, "y" : 543 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 102873, "type" : "INPUT", "segments" : [ { "from" : { "x" : 382, "y" : 579 }, "to" : { "x" : 485, "y" : 598 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102862, "reactomeId" : 8869365, "displayName" : "NAR", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 250, "y" : 579 }, "minX" : 229, "maxX" : 272, "minY" : 543, "maxY" : 594, "prop" : { "x" : 229, "y" : 564, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 233, "y" : 568 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 266, "y" : 569 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 266, "y" : 569 } } }, "connectors" : [ { "edgeId" : 102861, "type" : "INPUT", "segments" : [ { "from" : { "x" : 251, "y" : 561 }, "to" : { "x" : 253, "y" : 543 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102865, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 230, "y" : 431 }, "minX" : 210, "maxX" : 254, "minY" : 415, "maxY" : 483, "prop" : { "x" : 210, "y" : 416, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 214, "y" : 420 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 246, "y" : 421 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 246, "y" : 421 } } }, "connectors" : [ { "edgeId" : 102861, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 236, "y" : 449 }, "to" : { "x" : 254, "y" : 483 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 243, "y" : 453 }, "b" : { "x" : 236, "y" : 449 }, "c" : { "x" : 236, "y" : 457 }, "type" : "ARROW", "centre" : { "x" : 236, "y" : 457 } } } ] }, { "id" : 102864, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 317, "y" : 426 }, "minX" : 254, "maxX" : 336, "minY" : 410, "maxY" : 483, "prop" : { "x" : 299, "y" : 411, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 303, "y" : 415 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 330, "y" : 416 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 330, "y" : 416 } } }, "connectors" : [ { "edgeId" : 102861, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 300, "y" : 444 }, "to" : { "x" : 254, "y" : 483 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 297, "y" : 452 }, "b" : { "x" : 300, "y" : 444 }, "c" : { "x" : 292, "y" : 445 }, "type" : "ARROW", "centre" : { "x" : 292, "y" : 445 } } } ], "trivial" : true }, { "id" : 102867, "reactomeId" : 113526, "displayName" : "NAD+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1461, "y" : 739 }, "minX" : 1435, "maxX" : 1504, "minY" : 723, "maxY" : 780, "prop" : { "x" : 1435, "y" : 724, "width" : 53, "height" : 30 }, "textPosition" : { "x" : 1439, "y" : 728 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1483, "y" : 729 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1483, "y" : 729 } } }, "connectors" : [ { "edgeId" : 102866, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1476, "y" : 757 }, "to" : { "x" : 1504, "y" : 780 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 102876, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102869, "reactomeId" : 113563, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1641, "y" : 780 }, "minX" : 1573, "maxX" : 1672, "minY" : 764, "maxY" : 795, "prop" : { "x" : 1611, "y" : 765, "width" : 60, "height" : 30 }, "textPosition" : { "x" : 1615, "y" : 769 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1666, "y" : 770 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1666, "y" : 770 } } }, "connectors" : [ { "edgeId" : 102866, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1608, "y" : 780 }, "to" : { "x" : 1573, "y" : 780 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1601, "y" : 784 }, "b" : { "x" : 1608, "y" : 780 }, "c" : { "x" : 1601, "y" : 776 }, "type" : "ARROW", "centre" : { "x" : 1601, "y" : 776 } } } ] }, { "id" : 102868, "reactomeId" : 113593, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1467, "y" : 819 }, "minX" : 1447, "maxX" : 1504, "minY" : 780, "maxY" : 834, "prop" : { "x" : 1447, "y" : 804, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1451, "y" : 808 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1482, "y" : 809 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1482, "y" : 809 } } }, "connectors" : [ { "edgeId" : 102866, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1481, "y" : 801 }, "to" : { "x" : 1504, "y" : 780 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102871, "reactomeId" : 113581, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1590, "y" : 654 }, "minX" : 1524, "maxX" : 1612, "minY" : 581, "maxY" : 780, "prop" : { "x" : 1570, "y" : 639, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1574, "y" : 643 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1606, "y" : 644 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1606, "y" : 644 } } }, "connectors" : [ { "edgeId" : 102888, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1576, "y" : 636 }, "to" : { "x" : 1524, "y" : 581 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1568, "y" : 634 }, "b" : { "x" : 1576, "y" : 636 }, "c" : { "x" : 1574, "y" : 628 }, "type" : "ARROW", "centre" : { "x" : 1574, "y" : 628 } } }, { "edgeId" : 102866, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1587, "y" : 672 }, "to" : { "x" : 1573, "y" : 780 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1590, "y" : 679 }, "b" : { "x" : 1587, "y" : 672 }, "c" : { "x" : 1582, "y" : 678 }, "type" : "ARROW", "centre" : { "x" : 1582, "y" : 678 } } } ] }, { "id" : 102870, "reactomeId" : 113529, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1539, "y" : 653 }, "minX" : 1521, "maxX" : 1573, "minY" : 581, "maxY" : 780, "prop" : { "x" : 1521, "y" : 638, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 1525, "y" : 642 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1552, "y" : 643 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1552, "y" : 643 } } }, "connectors" : [ { "edgeId" : 102888, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1535, "y" : 635 }, "to" : { "x" : 1524, "y" : 581 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1523, "y" : 602 }, "b" : { "x" : 1535, "y" : 614 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1529, "y" : 608 } } }, "endShape" : { "a" : { "x" : 1530, "y" : 629 }, "b" : { "x" : 1535, "y" : 635 }, "c" : { "x" : 1538, "y" : 627 }, "type" : "ARROW", "centre" : { "x" : 1538, "y" : 627 } } }, { "edgeId" : 102866, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1543, "y" : 671 }, "to" : { "x" : 1573, "y" : 780 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1549, "y" : 677 }, "b" : { "x" : 1543, "y" : 671 }, "c" : { "x" : 1541, "y" : 679 }, "type" : "ARROW", "centre" : { "x" : 1541, "y" : 679 } } } ], "trivial" : true }, { "id" : 102872, "reactomeId" : 10314736, "displayName" : "NADK2 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1546, "y" : 839 }, "minX" : 1502, "maxX" : 1597, "minY" : 788, "maxY" : 850, "prop" : { "x" : 1502, "y" : 828, "width" : 89, "height" : 22 }, "textPosition" : { "x" : 1502, "y" : 829 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1591, "y" : 828 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1591, "y" : 828 } } }, "connectors" : [ { "edgeId" : 102866, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1545, "y" : 825 }, "to" : { "x" : 1545, "y" : 796 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1545, "y" : 792 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1545, "y" : 792 } } } ] }, { "id" : 102875, "reactomeId" : 111294, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 541, "y" : 680 }, "minX" : 484, "maxX" : 559, "minY" : 664, "maxY" : 695, "prop" : { "x" : 524, "y" : 665, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 527, "y" : 669 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 553, "y" : 670 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 553, "y" : 670 } } }, "connectors" : [ { "edgeId" : 102873, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 521, "y" : 676 }, "to" : { "x" : 484, "y" : 668 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 513, "y" : 678 }, "b" : { "x" : 521, "y" : 676 }, "c" : { "x" : 515, "y" : 671 }, "type" : "ARROW", "centre" : { "x" : 515, "y" : 671 } } } ] }, { "id" : 102874, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 531, "y" : 573 }, "minX" : 485, "maxX" : 550, "minY" : 557, "maxY" : 598, "prop" : { "x" : 513, "y" : 558, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 517, "y" : 562 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 544, "y" : 563 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 544, "y" : 563 } } }, "connectors" : [ { "edgeId" : 102873, "type" : "INPUT", "segments" : [ { "from" : { "x" : 510, "y" : 582 }, "to" : { "x" : 485, "y" : 598 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 102877, "reactomeId" : 29360, "displayName" : "NAD+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1312, "y" : 737 }, "minX" : 1283, "maxX" : 1342, "minY" : 719, "maxY" : 754, "prop" : { "x" : 1283, "y" : 720, "width" : 58, "height" : 34 }, "textPosition" : { "x" : 1290, "y" : 726 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1336, "y" : 725 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1336, "y" : 725 } } }, "connectors" : [ { "edgeId" : 102876, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102878, "reactomeId" : 10327599, "displayName" : "SLC25A51", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1380, "y" : 694 }, "minX" : 1346, "maxX" : 1421, "minY" : 677, "maxY" : 729, "prop" : { "x" : 1346, "y" : 683, "width" : 69, "height" : 23 }, "textPosition" : { "x" : 1349, "y" : 677 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1415, "y" : 683 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1415, "y" : 683 } } }, "connectors" : [ { "edgeId" : 102876, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1380, "y" : 709 }, "to" : { "x" : 1380, "y" : 721 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1381, "y" : 725 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1381, "y" : 725 } } } ] }, { "id" : 102881, "reactomeId" : 549282, "displayName" : "MNA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1283, "y" : 961 }, "minX" : 1212, "maxX" : 1306, "minY" : 945, "maxY" : 976, "prop" : { "x" : 1261, "y" : 946, "width" : 44, "height" : 30 }, "textPosition" : { "x" : 1265, "y" : 950 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1300, "y" : 951 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1300, "y" : 951 } } }, "connectors" : [ { "edgeId" : 102879, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1258, "y" : 961 }, "to" : { "x" : 1212, "y" : 961 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1251, "y" : 965 }, "b" : { "x" : 1258, "y" : 961 }, "c" : { "x" : 1251, "y" : 957 }, "type" : "ARROW", "centre" : { "x" : 1251, "y" : 957 } } } ] }, { "id" : 102880, "reactomeId" : 71284, "displayName" : "AdoMet", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1095, "y" : 1002 }, "minX" : 1065, "maxX" : 1127, "minY" : 961, "maxY" : 1017, "prop" : { "x" : 1065, "y" : 987, "width" : 61, "height" : 30 }, "textPosition" : { "x" : 1068, "y" : 991 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1121, "y" : 992 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1121, "y" : 992 } } }, "connectors" : [ { "edgeId" : 102879, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1103, "y" : 984 }, "to" : { "x" : 1117, "y" : 961 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102883, "reactomeId" : 10240127, "displayName" : "NNMT", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1160, "y" : 910 }, "minX" : 1138, "maxX" : 1189, "minY" : 893, "maxY" : 953, "prop" : { "x" : 1138, "y" : 899, "width" : 45, "height" : 22 }, "textPosition" : { "x" : 1139, "y" : 899 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1183, "y" : 899 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1183, "y" : 899 } } }, "connectors" : [ { "edgeId" : 102879, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1160, "y" : 924 }, "to" : { "x" : 1161, "y" : 945 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1161, "y" : 949 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1161, "y" : 949 } } } ] }, { "id" : 102882, "reactomeId" : 71285, "displayName" : "AdoHcy", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1235, "y" : 1003 }, "minX" : 1205, "maxX" : 1267, "minY" : 961, "maxY" : 1018, "prop" : { "x" : 1205, "y" : 988, "width" : 61, "height" : 30 }, "textPosition" : { "x" : 1208, "y" : 992 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1261, "y" : 993 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1261, "y" : 993 } } }, "connectors" : [ { "edgeId" : 102879, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1226, "y" : 985 }, "to" : { "x" : 1212, "y" : 961 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1219, "y" : 981 }, "b" : { "x" : 1226, "y" : 985 }, "c" : { "x" : 1226, "y" : 977 }, "type" : "ARROW", "centre" : { "x" : 1226, "y" : 977 } } } ] }, { "id" : 102885, "reactomeId" : 6807473, "displayName" : "R-NADPHX", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1524, "y" : 347 }, "minX" : 1483, "maxX" : 1566, "minY" : 331, "maxY" : 362, "prop" : { "x" : 1483, "y" : 332, "width" : 82, "height" : 30 }, "textPosition" : { "x" : 1489, "y" : 336 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1560, "y" : 337 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1560, "y" : 337 } } }, "connectors" : [ { "edgeId" : 102884, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102887, "reactomeId" : 10304241, "displayName" : "APOA1BP dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1442, "y" : 391 }, "minX" : 1406, "maxX" : 1515, "minY" : 368, "maxY" : 409, "prop" : { "x" : 1406, "y" : 374, "width" : 72, "height" : 35 }, "textPosition" : { "x" : 1407, "y" : 374 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1478, "y" : 374 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1478, "y" : 374 } } }, "connectors" : [ { "edgeId" : 102884, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1481, "y" : 393 }, "to" : { "x" : 1507, "y" : 395 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1511, "y" : 396 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1511, "y" : 396 } } } ] }, { "id" : 102886, "reactomeId" : 6807477, "displayName" : "S-NADPHX", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1522, "y" : 448 }, "minX" : 1482, "maxX" : 1563, "minY" : 432, "maxY" : 510, "prop" : { "x" : 1482, "y" : 433, "width" : 80, "height" : 30 }, "textPosition" : { "x" : 1487, "y" : 437 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1557, "y" : 438 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1557, "y" : 438 } } }, "connectors" : [ { "edgeId" : 102884, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 102888, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1522, "y" : 466 }, "to" : { "x" : 1522, "y" : 510 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102889, "reactomeId" : 113593, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1475, "y" : 481 }, "minX" : 1455, "maxX" : 1522, "minY" : 465, "maxY" : 510, "prop" : { "x" : 1455, "y" : 466, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1459, "y" : 470 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1490, "y" : 471 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1490, "y" : 471 } } }, "connectors" : [ { "edgeId" : 102888, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1498, "y" : 493 }, "to" : { "x" : 1522, "y" : 510 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102891, "reactomeId" : 113600, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1467, "y" : 619 }, "minX" : 1438, "maxX" : 1524, "minY" : 581, "maxY" : 634, "prop" : { "x" : 1438, "y" : 604, "width" : 59, "height" : 30 }, "textPosition" : { "x" : 1442, "y" : 608 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1492, "y" : 609 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1492, "y" : 609 } } }, "connectors" : [ { "edgeId" : 102888, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1489, "y" : 601 }, "to" : { "x" : 1524, "y" : 581 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1493, "y" : 594 }, "b" : { "x" : 1489, "y" : 601 }, "c" : { "x" : 1497, "y" : 601 }, "type" : "ARROW", "centre" : { "x" : 1497, "y" : 601 } } } ] }, { "id" : 102890, "reactomeId" : 113548, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1495, "y" : 649 }, "minX" : 1482, "maxX" : 1524, "minY" : 581, "maxY" : 664, "prop" : { "x" : 1482, "y" : 634, "width" : 27, "height" : 30 }, "textPosition" : { "x" : 1486, "y" : 638 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1504, "y" : 639 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1504, "y" : 639 } } }, "connectors" : [ { "edgeId" : 102888, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1501, "y" : 631 }, "to" : { "x" : 1524, "y" : 581 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1500, "y" : 623 }, "b" : { "x" : 1501, "y" : 631 }, "c" : { "x" : 1508, "y" : 626 }, "type" : "ARROW", "centre" : { "x" : 1508, "y" : 626 } } } ] }, { "id" : 102892, "reactomeId" : 10304248, "displayName" : "CARKD", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1458, "y" : 541 }, "minX" : 1433, "maxX" : 1515, "minY" : 524, "maxY" : 552, "prop" : { "x" : 1433, "y" : 530, "width" : 50, "height" : 22 }, "textPosition" : { "x" : 1434, "y" : 530 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1483, "y" : 530 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1483, "y" : 530 } } }, "connectors" : [ { "edgeId" : 102888, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1486, "y" : 541 }, "to" : { "x" : 1507, "y" : 542 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1511, "y" : 542 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1511, "y" : 542 } } } ] }, { "id" : 102895, "reactomeId" : 141343, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1873, "y" : 800 }, "minX" : 1852, "maxX" : 1913, "minY" : 764, "maxY" : 816, "prop" : { "x" : 1852, "y" : 785, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1856, "y" : 790 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1890, "y" : 790 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1890, "y" : 790 } } }, "connectors" : [ { "edgeId" : 102893, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1890, "y" : 782 }, "to" : { "x" : 1913, "y" : 764 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 102894, "reactomeId" : 192305, "displayName" : "NADH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1873, "y" : 720 }, "minX" : 1847, "maxX" : 1913, "minY" : 704, "maxY" : 764, "prop" : { "x" : 1847, "y" : 705, "width" : 52, "height" : 30 }, "textPosition" : { "x" : 1851, "y" : 709 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1894, "y" : 710 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1894, "y" : 710 } } }, "connectors" : [ { "edgeId" : 102893, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1886, "y" : 738 }, "to" : { "x" : 1913, "y" : 764 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102897, "reactomeId" : 193465, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2064, "y" : 711 }, "minX" : 2036, "maxX" : 2083, "minY" : 695, "maxY" : 764, "prop" : { "x" : 2046, "y" : 696, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 2050, "y" : 700 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2077, "y" : 701 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2077, "y" : 701 } } }, "connectors" : [ { "edgeId" : 102893, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2056, "y" : 729 }, "to" : { "x" : 2036, "y" : 764 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2040, "y" : 740 }, "b" : { "x" : 2052, "y" : 752 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2046, "y" : 746 } } }, "endShape" : { "a" : { "x" : 2056, "y" : 737 }, "b" : { "x" : 2056, "y" : 729 }, "c" : { "x" : 2049, "y" : 733 }, "type" : "ARROW", "centre" : { "x" : 2049, "y" : 733 } } } ], "trivial" : true }, { "id" : 102896, "reactomeId" : 389620, "displayName" : "AMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2113, "y" : 765 }, "minX" : 2036, "maxX" : 2135, "minY" : 749, "maxY" : 780, "prop" : { "x" : 2092, "y" : 750, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 2096, "y" : 754 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2129, "y" : 755 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2129, "y" : 755 } } }, "connectors" : [ { "edgeId" : 102893, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2089, "y" : 764 }, "to" : { "x" : 2036, "y" : 764 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2082, "y" : 768 }, "b" : { "x" : 2089, "y" : 764 }, "c" : { "x" : 2082, "y" : 760 }, "type" : "ARROW", "centre" : { "x" : 2082, "y" : 760 } } } ] }, { "id" : 102899, "reactomeId" : 10304855, "displayName" : "NUDT12", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1973, "y" : 724 }, "minX" : 1944, "maxX" : 2009, "minY" : 707, "maxY" : 756, "prop" : { "x" : 1944, "y" : 713, "width" : 59, "height" : 22 }, "textPosition" : { "x" : 1944, "y" : 713 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2003, "y" : 713 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2003, "y" : 713 } } }, "connectors" : [ { "edgeId" : 102893, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1973, "y" : 738 }, "to" : { "x" : 1974, "y" : 748 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1974, "y" : 752 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1974, "y" : 752 } } } ] }, { "id" : 102898, "reactomeId" : 6809289, "displayName" : "NMNH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2056, "y" : 800 }, "minX" : 2029, "maxX" : 2084, "minY" : 764, "maxY" : 815, "prop" : { "x" : 2029, "y" : 785, "width" : 54, "height" : 30 }, "textPosition" : { "x" : 2033, "y" : 789 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2078, "y" : 790 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2078, "y" : 790 } } }, "connectors" : [ { "edgeId" : 102893, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2047, "y" : 782 }, "to" : { "x" : 2036, "y" : 764 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2040, "y" : 778 }, "b" : { "x" : 2047, "y" : 782 }, "c" : { "x" : 2047, "y" : 774 }, "type" : "ARROW", "centre" : { "x" : 2047, "y" : 774 } } } ] }, { "id" : 102901, "reactomeId" : 352327, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1561, "y" : 30 }, "minX" : 1547, "maxX" : 1618, "minY" : 15, "maxY" : 73, "prop" : { "x" : 1547, "y" : 16, "width" : 29, "height" : 29 }, "textPosition" : { "x" : 1549, "y" : 20 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1571, "y" : 21 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1571, "y" : 21 } } }, "connectors" : [ { "edgeId" : 102900, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1579, "y" : 40 }, "to" : { "x" : 1618, "y" : 73 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 102903, "reactomeId" : 351629, "displayName" : "H2O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1780, "y" : 23 }, "minX" : 1734, "maxX" : 1802, "minY" : 7, "maxY" : 73, "prop" : { "x" : 1759, "y" : 8, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 1759, "y" : 12 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1796, "y" : 13 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1796, "y" : 13 } } }, "connectors" : [ { "edgeId" : 102900, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1766, "y" : 41 }, "to" : { "x" : 1734, "y" : 73 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1764, "y" : 49 }, "b" : { "x" : 1766, "y" : 41 }, "c" : { "x" : 1758, "y" : 43 }, "type" : "ARROW", "centre" : { "x" : 1758, "y" : 43 } } } ] }, { "id" : 102902, "reactomeId" : 8956473, "displayName" : "dh-beta-NAD", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1505, "y" : 69 }, "minX" : 1471, "maxX" : 1618, "minY" : 53, "maxY" : 85, "prop" : { "x" : 1471, "y" : 53, "width" : 68, "height" : 32 }, "textPosition" : { "x" : 1474, "y" : 52 }, "connectors" : [ { "edgeId" : 102900, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1545, "y" : 70 }, "to" : { "x" : 1618, "y" : 73 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 102904, "reactomeId" : 10314880, "displayName" : "RNLS:FAD", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1678, "y" : 17 }, "minX" : 1641, "maxX" : 1722, "minY" : 0, "maxY" : 65, "prop" : { "x" : 1641, "y" : 6, "width" : 75, "height" : 22 }, "textPosition" : { "x" : 1645, "y" : 7 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1716, "y" : 6 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1716, "y" : 6 } } }, "connectors" : [ { "edgeId" : 102900, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1677, "y" : 31 }, "to" : { "x" : 1676, "y" : 57 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1676, "y" : 61 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1676, "y" : 61 } } } ] }, { "id" : 102908, "reactomeId" : 36027, "displayName" : "ACS", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 324, "y" : 303 }, "minX" : 305, "maxX" : 345, "minY" : 287, "maxY" : 318, "prop" : { "x" : 305, "y" : 288, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 308, "y" : 292 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 339, "y" : 293 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 339, "y" : 293 } } }, "connectors" : [ ] } ], "edges" : [ { "id" : 102848, "reactomeId" : 10312062, "displayName" : "NT5E:Zn2+ hydrolyses NAD+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1872, "y" : 178 }, "minX" : 1833, "maxX" : 1920, "minY" : 172, "maxY" : 184, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1833, "y" : 178 }, "to" : { "x" : 1872, "y" : 178 } }, { "from" : { "x" : 1872, "y" : 178 }, "to" : { "x" : 1920, "y" : 178 } } ], "reactionShape" : { "a" : { "x" : 1866, "y" : 172 }, "b" : { "x" : 1878, "y" : 184 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1872, "y" : 178 } }, "inputs" : [ { "id" : 102849, "points" : [ { "x" : 1821, "y" : 161 } ] }, { "id" : 102819, "points" : [ { "x" : 1793, "y" : 177 } ] } ], "outputs" : [ { "id" : 102850, "points" : [ { "x" : 1977, "y" : 178 } ] }, { "id" : 102851, "points" : [ { "x" : 1940, "y" : 128 } ] }, { "id" : 102852, "points" : [ { "x" : 1967, "y" : 145 } ] }, { "id" : 102853, "points" : [ { "x" : 1899, "y" : 147 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 102854, "points" : [ { "x" : 1973, "y" : 213 } ] } ] }, { "id" : 102784, "reactomeId" : 10243192, "displayName" : "NADSYN1 hexamer amidates NAAD to NAD+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 485, "y" : 838 }, "minX" : 479, "maxX" : 491, "minY" : 801, "maxY" : 883, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 485, "y" : 801 }, "to" : { "x" : 485, "y" : 838 } }, { "from" : { "x" : 485, "y" : 838 }, "to" : { "x" : 485, "y" : 883 } } ], "reactionShape" : { "a" : { "x" : 479, "y" : 832 }, "b" : { "x" : 491, "y" : 844 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 485, "y" : 838 } }, "inputs" : [ { "id" : 102785, "points" : [ { "x" : 440, "y" : 762 } ] }, { "id" : 102786, "points" : [ { "x" : 513, "y" : 784 } ] }, { "id" : 102787, "points" : [ { "x" : 485, "y" : 744 } ] }, { "id" : 102788, "points" : [ { "x" : 447, "y" : 790 } ] } ], "outputs" : [ { "id" : 102789, "points" : [ { "x" : 486, "y" : 948 } ] }, { "id" : 102790, "points" : [ { "x" : 511, "y" : 880 } ] }, { "id" : 102791, "points" : [ { "x" : 459, "y" : 902 } ] }, { "id" : 102792, "points" : [ { "x" : 453, "y" : 876 } ] }, { "id" : 102793, "points" : [ { "x" : 513, "y" : 906 } ] } ], "catalysts" : [ { "id" : 102794, "points" : [ { "x" : 521, "y" : 837 } ] } ] }, { "id" : 102818, "reactomeId" : 10311843, "displayName" : "CD38 hydrolyses NAD+ to NAM and ADP-ribose", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1633, "y" : 150 }, "minX" : 1591, "maxX" : 1662, "minY" : 144, "maxY" : 156, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1662, "y" : 150 }, "to" : { "x" : 1633, "y" : 150 } }, { "from" : { "x" : 1633, "y" : 150 }, "to" : { "x" : 1591, "y" : 150 } } ], "reactionShape" : { "a" : { "x" : 1627, "y" : 144 }, "b" : { "x" : 1639, "y" : 156 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1633, "y" : 150 } }, "inputs" : [ { "id" : 102819, "points" : [ { "x" : 1734, "y" : 169 } ] }, { "id" : 102820, "points" : [ { "x" : 1692, "y" : 133 } ] } ], "outputs" : [ { "id" : 102821, "points" : [ { "x" : 1501, "y" : 150 } ] }, { "id" : 102822, "points" : [ { "x" : 1541, "y" : 120 } ] }, { "id" : 102823, "points" : [ { "x" : 1511, "y" : 176 } ] } ], "catalysts" : [ { "id" : 102824, "points" : [ { "x" : 1676, "y" : 212 } ] } ] }, { "id" : 102884, "reactomeId" : 10304244, "displayName" : "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1523, "y" : 397 }, "minX" : 1517, "maxX" : 1529, "minY" : 365, "maxY" : 430, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1523, "y" : 365 }, "to" : { "x" : 1523, "y" : 397 } }, { "from" : { "x" : 1523, "y" : 397 }, "to" : { "x" : 1522, "y" : 430 } } ], "endShape" : { "a" : { "x" : 1518, "y" : 423 }, "b" : { "x" : 1522, "y" : 430 }, "c" : { "x" : 1526, "y" : 423 }, "type" : "ARROW", "centre" : { "x" : 1526, "y" : 423 } }, "reactionShape" : { "a" : { "x" : 1517, "y" : 391 }, "b" : { "x" : 1529, "y" : 403 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1523, "y" : 397 } }, "inputs" : [ { "id" : 102885 } ], "outputs" : [ { "id" : 102886 } ], "catalysts" : [ { "id" : 102887, "points" : [ { "x" : 1481, "y" : 393 } ] } ] }, { "id" : 102855, "reactomeId" : 10312064, "displayName" : "NT5E:Zn2+ hydrolyses NMN", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2105, "y" : 178 }, "minX" : 2075, "maxX" : 2135, "minY" : 172, "maxY" : 184, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2075, "y" : 178 }, "to" : { "x" : 2105, "y" : 178 } }, { "from" : { "x" : 2105, "y" : 178 }, "to" : { "x" : 2135, "y" : 178 } } ], "reactionShape" : { "a" : { "x" : 2099, "y" : 172 }, "b" : { "x" : 2111, "y" : 184 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2105, "y" : 178 } }, "inputs" : [ { "id" : 102856, "points" : [ { "x" : 2054, "y" : 161 } ] }, { "id" : 102850, "points" : [ { "x" : 2028, "y" : 178 } ] } ], "outputs" : [ { "id" : 102857, "points" : [ { "x" : 2189, "y" : 178 } ] }, { "id" : 102858, "points" : [ { "x" : 2176, "y" : 146 } ] } ], "catalysts" : [ { "id" : 102854, "points" : [ { "x" : 2025, "y" : 213 } ] } ] }, { "id" : 102825, "reactomeId" : 10309812, "displayName" : "SLC22A13 exchanges extracellular NCA for cytosolic urate", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1016, "y" : 229 }, "minX" : 1010, "maxX" : 1022, "minY" : 223, "maxY" : 235, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1016, "y" : 230 }, "to" : { "x" : 1016, "y" : 229 } }, { "from" : { "x" : 1016, "y" : 229 }, "to" : { "x" : 1020, "y" : 230 } } ], "reactionShape" : { "a" : { "x" : 1010, "y" : 223 }, "b" : { "x" : 1022, "y" : 235 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1016, "y" : 229 } }, "inputs" : [ { "id" : 102826, "points" : [ { "x" : 977, "y" : 259 } ] }, { "id" : 102827, "points" : [ { "x" : 1016, "y" : 178 } ] } ], "outputs" : [ { "id" : 102809, "points" : [ { "x" : 1016, "y" : 497 } ] }, { "id" : 102828, "points" : [ { "x" : 1054, "y" : 203 } ] } ], "catalysts" : [ { "id" : 102829, "points" : [ { "x" : 970, "y" : 229 } ] } ] }, { "id" : 102888, "reactomeId" : 10304251, "displayName" : "CARKD dehydrates S-NAD(P)HX to NADPH", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1523, "y" : 542 }, "minX" : 1517, "maxX" : 1529, "minY" : 510, "maxY" : 581, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1522, "y" : 510 }, "to" : { "x" : 1523, "y" : 542 } }, { "from" : { "x" : 1523, "y" : 542 }, "to" : { "x" : 1524, "y" : 581 } } ], "reactionShape" : { "a" : { "x" : 1517, "y" : 536 }, "b" : { "x" : 1529, "y" : 548 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1523, "y" : 542 } }, "inputs" : [ { "id" : 102886, "points" : [ { "x" : 1522, "y" : 466 } ] }, { "id" : 102889, "points" : [ { "x" : 1498, "y" : 493 } ] } ], "outputs" : [ { "id" : 102870, "points" : [ { "x" : 1535, "y" : 635 } ], "stoichiometry" : 3 }, { "id" : 102890, "points" : [ { "x" : 1501, "y" : 631 } ] }, { "id" : 102891, "points" : [ { "x" : 1489, "y" : 601 } ] }, { "id" : 102871, "points" : [ { "x" : 1576, "y" : 636 } ] } ], "catalysts" : [ { "id" : 102892, "points" : [ { "x" : 1486, "y" : 541 } ] } ] }, { "id" : 102795, "reactomeId" : 10243160, "displayName" : "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 485, "y" : 1067 }, "minX" : 479, "maxX" : 491, "minY" : 1038, "maxY" : 1094, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 485, "y" : 1038 }, "to" : { "x" : 485, "y" : 1067 } }, { "from" : { "x" : 485, "y" : 1067 }, "to" : { "x" : 486, "y" : 1094 } } ], "reactionShape" : { "a" : { "x" : 479, "y" : 1061 }, "b" : { "x" : 491, "y" : 1073 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 485, "y" : 1067 } }, "inputs" : [ { "id" : 102796, "points" : [ { "x" : 508, "y" : 1027 } ] }, { "id" : 102789, "points" : [ { "x" : 486, "y" : 988 } ] } ], "outputs" : [ { "id" : 102797, "points" : [ { "x" : 508, "y" : 1102 } ] }, { "id" : 102798, "points" : [ { "x" : 487, "y" : 1132 } ] }, { "id" : 102799, "points" : [ { "x" : 453, "y" : 1112 } ] } ], "catalysts" : [ { "id" : 102800, "points" : [ { "x" : 445, "y" : 1067 } ] } ] }, { "id" : 102859, "reactomeId" : 10309858, "displayName" : "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1634, "y" : 176 }, "minX" : 1585, "maxX" : 1674, "minY" : 170, "maxY" : 182, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1674, "y" : 176 }, "to" : { "x" : 1634, "y" : 176 } }, { "from" : { "x" : 1634, "y" : 176 }, "to" : { "x" : 1585, "y" : 176 } } ], "reactionShape" : { "a" : { "x" : 1628, "y" : 170 }, "b" : { "x" : 1640, "y" : 182 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1634, "y" : 176 } }, "inputs" : [ { "id" : 102820, "points" : [ { "x" : 1704, "y" : 141 } ] }, { "id" : 102819, "points" : [ { "x" : 1734, "y" : 176 } ] } ], "outputs" : [ { "id" : 102821, "points" : [ { "x" : 1501, "y" : 155 } ] }, { "id" : 102822, "points" : [ { "x" : 1535, "y" : 129 } ] }, { "id" : 102823, "points" : [ { "x" : 1516, "y" : 187 } ] } ], "catalysts" : [ { "id" : 102860, "points" : [ { "x" : 1611, "y" : 211 } ] } ] }, { "id" : 102762, "reactomeId" : 10243183, "displayName" : "QPRT transfers PRIB to QUIN to form NAMN", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 484, "y" : 417 }, "minX" : 478, "maxX" : 490, "minY" : 379, "maxY" : 455, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 483, "y" : 379 }, "to" : { "x" : 484, "y" : 417 } }, { "from" : { "x" : 484, "y" : 417 }, "to" : { "x" : 484, "y" : 455 } } ], "reactionShape" : { "a" : { "x" : 478, "y" : 411 }, "b" : { "x" : 490, "y" : 423 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 484, "y" : 417 } }, "inputs" : [ { "id" : 102763, "points" : [ { "x" : 483, "y" : 321 } ] }, { "id" : 102764, "points" : [ { "x" : 458, "y" : 364 } ] }, { "id" : 102765, "points" : [ { "x" : 512, "y" : 357 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 102766, "points" : [ { "x" : 460, "y" : 465 } ] }, { "id" : 102767, "points" : [ { "x" : 517, "y" : 466 } ] }, { "id" : 102768, "points" : [ { "x" : 485, "y" : 499 } ] } ], "catalysts" : [ { "id" : 102769, "points" : [ { "x" : 447, "y" : 417 } ] } ] }, { "id" : 102861, "reactomeId" : 10309819, "displayName" : "NMRK1 phosphorylates NAR to yield NAMN", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 254, "y" : 517 }, "minX" : 248, "maxX" : 260, "minY" : 483, "maxY" : 543, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 253, "y" : 543 }, "to" : { "x" : 254, "y" : 517 } }, { "from" : { "x" : 254, "y" : 517 }, "to" : { "x" : 254, "y" : 483 } } ], "reactionShape" : { "a" : { "x" : 248, "y" : 511 }, "b" : { "x" : 260, "y" : 523 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 254, "y" : 517 } }, "inputs" : [ { "id" : 102862, "points" : [ { "x" : 251, "y" : 561 } ] }, { "id" : 102863, "points" : [ { "x" : 336, "y" : 569 } ] } ], "outputs" : [ { "id" : 102864, "points" : [ { "x" : 300, "y" : 444 } ] }, { "id" : 102865, "points" : [ { "x" : 236, "y" : 449 } ] }, { "id" : 102768, "points" : [ { "x" : 457, "y" : 513 } ] } ], "catalysts" : [ { "id" : 102847, "points" : [ { "x" : 143, "y" : 906 }, { "x" : 193, "y" : 517 } ] } ] }, { "id" : 102893, "reactomeId" : 10304858, "displayName" : "NUDT12 hydrolyses NADH to NMNH", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1975, "y" : 764 }, "minX" : 1913, "maxX" : 2036, "minY" : 758, "maxY" : 770, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1913, "y" : 764 }, "to" : { "x" : 1975, "y" : 764 } }, { "from" : { "x" : 1975, "y" : 764 }, "to" : { "x" : 2036, "y" : 764 } } ], "reactionShape" : { "a" : { "x" : 1969, "y" : 758 }, "b" : { "x" : 1981, "y" : 770 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1975, "y" : 764 } }, "inputs" : [ { "id" : 102894, "points" : [ { "x" : 1886, "y" : 738 } ] }, { "id" : 102895, "points" : [ { "x" : 1890, "y" : 782 } ] } ], "outputs" : [ { "id" : 102896, "points" : [ { "x" : 2089, "y" : 764 } ] }, { "id" : 102897, "points" : [ { "x" : 2056, "y" : 729 } ], "stoichiometry" : 2 }, { "id" : 102898, "points" : [ { "x" : 2047, "y" : 782 } ] } ], "catalysts" : [ { "id" : 102899, "points" : [ { "x" : 1973, "y" : 738 } ] } ] }, { "id" : 102830, "reactomeId" : 10256200, "displayName" : "SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1191, "y" : 228 }, "minX" : 1185, "maxX" : 1197, "minY" : 209, "maxY" : 275, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1191, "y" : 209 }, "to" : { "x" : 1191, "y" : 228 } }, { "from" : { "x" : 1191, "y" : 228 }, "to" : { "x" : 1191, "y" : 275 } } ], "reactionShape" : { "a" : { "x" : 1185, "y" : 222 }, "b" : { "x" : 1197, "y" : 234 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1191, "y" : 228 } }, "inputs" : [ { "id" : 102831, "points" : [ { "x" : 1191, "y" : 190 } ] }, { "id" : 102832, "points" : [ { "x" : 1263, "y" : 193 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 102833, "points" : [ { "x" : 1191, "y" : 323 } ] }, { "id" : 102834, "points" : [ { "x" : 1248, "y" : 297 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 102835, "points" : [ { "x" : 1152, "y" : 228 } ] } ] }, { "id" : 102801, "reactomeId" : 10243176, "displayName" : "NAMPT transfers PRIB to NAM to form NAMN", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1014, "y" : 781 }, "minX" : 1008, "maxX" : 1020, "minY" : 739, "maxY" : 829, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1015, "y" : 829 }, "to" : { "x" : 1014, "y" : 781 } }, { "from" : { "x" : 1014, "y" : 781 }, "to" : { "x" : 1014, "y" : 739 } } ], "reactionShape" : { "a" : { "x" : 1008, "y" : 775 }, "b" : { "x" : 1020, "y" : 787 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1014, "y" : 781 } }, "inputs" : [ { "id" : 102802, "points" : [ { "x" : 1015, "y" : 944 } ] }, { "id" : 102803, "points" : [ { "x" : 1038, "y" : 846 } ] }, { "id" : 102804, "points" : [ { "x" : 997, "y" : 844 } ] } ], "outputs" : [ { "id" : 102805, "points" : [ { "x" : 1043, "y" : 726 } ] }, { "id" : 102806, "points" : [ { "x" : 1014, "y" : 696 } ] } ], "catalysts" : [ { "id" : 102807, "points" : [ { "x" : 979, "y" : 781 } ] } ] }, { "id" : 102770, "reactomeId" : 10244345, "displayName" : "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1947, "y" : 490 }, "minX" : 1908, "maxX" : 1987, "minY" : 484, "maxY" : 496, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1908, "y" : 490 }, "to" : { "x" : 1947, "y" : 490 } }, { "from" : { "x" : 1947, "y" : 490 }, "to" : { "x" : 1987, "y" : 490 } } ], "reactionShape" : { "a" : { "x" : 1941, "y" : 484 }, "b" : { "x" : 1953, "y" : 496 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1947, "y" : 490 } }, "inputs" : [ { "id" : 102771, "points" : [ { "x" : 1878, "y" : 490 } ] }, { "id" : 102772, "points" : [ { "x" : 1908, "y" : 514 } ] }, { "id" : 102773, "points" : [ { "x" : 1875, "y" : 515 } ] } ], "outputs" : [ { "id" : 102774, "points" : [ { "x" : 2018, "y" : 490 } ] }, { "id" : 102775, "points" : [ { "x" : 2009, "y" : 517 } ] } ], "catalysts" : [ { "id" : 102776, "points" : [ { "x" : 1947, "y" : 454 } ] } ] }, { "id" : 102866, "reactomeId" : 10314739, "displayName" : "NADK2 dimer phosphorylates NAD+ to NADP+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1545, "y" : 780 }, "minX" : 1504, "maxX" : 1573, "minY" : 774, "maxY" : 786, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1504, "y" : 780 }, "to" : { "x" : 1545, "y" : 780 } }, { "from" : { "x" : 1545, "y" : 780 }, "to" : { "x" : 1573, "y" : 780 } } ], "reactionShape" : { "a" : { "x" : 1539, "y" : 774 }, "b" : { "x" : 1551, "y" : 786 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1545, "y" : 780 } }, "inputs" : [ { "id" : 102867, "points" : [ { "x" : 1476, "y" : 757 } ] }, { "id" : 102868, "points" : [ { "x" : 1481, "y" : 801 } ] } ], "outputs" : [ { "id" : 102869, "points" : [ { "x" : 1608, "y" : 780 } ] }, { "id" : 102870, "points" : [ { "x" : 1543, "y" : 671 } ] }, { "id" : 102871, "points" : [ { "x" : 1587, "y" : 672 } ] } ], "catalysts" : [ { "id" : 102872, "points" : [ { "x" : 1545, "y" : 825 } ] } ] }, { "id" : 102836, "reactomeId" : 10312044, "displayName" : "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 374, "y" : 964 }, "minX" : 333, "maxX" : 403, "minY" : 958, "maxY" : 970, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 333, "y" : 964 }, "to" : { "x" : 374, "y" : 964 } }, { "from" : { "x" : 374, "y" : 964 }, "to" : { "x" : 403, "y" : 965 } } ], "reactionShape" : { "a" : { "x" : 368, "y" : 958 }, "b" : { "x" : 380, "y" : 970 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 374, "y" : 964 } }, "inputs" : [ { "id" : 102837, "points" : [ { "x" : 293, "y" : 964 } ] }, { "id" : 102838, "points" : [ { "x" : 322, "y" : 980 } ] }, { "id" : 102839, "points" : [ { "x" : 323, "y" : 940 } ] } ], "outputs" : [ { "id" : 102789, "points" : [ { "x" : 455, "y" : 966 } ] }, { "id" : 102840, "points" : [ { "x" : 418, "y" : 985 } ] } ], "catalysts" : [ { "id" : 102841, "points" : [ { "x" : 374, "y" : 645 } ] } ] }, { "id" : 102900, "reactomeId" : 10314883, "displayName" : "RNLS:FAD oxidises dh-beta-NAD to NAD+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1676, "y" : 73 }, "minX" : 1618, "maxX" : 1734, "minY" : 67, "maxY" : 79, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1618, "y" : 73 }, "to" : { "x" : 1676, "y" : 73 } }, { "from" : { "x" : 1676, "y" : 73 }, "to" : { "x" : 1734, "y" : 73 } } ], "reactionShape" : { "a" : { "x" : 1670, "y" : 67 }, "b" : { "x" : 1682, "y" : 79 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1676, "y" : 73 } }, "inputs" : [ { "id" : 102901, "points" : [ { "x" : 1579, "y" : 40 } ] }, { "id" : 102822, "points" : [ { "x" : 1541, "y" : 104 } ] }, { "id" : 102902, "points" : [ { "x" : 1545, "y" : 70 } ] } ], "outputs" : [ { "id" : 102819, "points" : [ { "x" : 1758, "y" : 159 } ] }, { "id" : 102903, "points" : [ { "x" : 1766, "y" : 41 } ] } ], "catalysts" : [ { "id" : 102904, "points" : [ { "x" : 1677, "y" : 31 } ] } ] }, { "id" : 102777, "reactomeId" : 10244336, "displayName" : "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1679, "y" : 531 }, "minX" : 1673, "maxX" : 1685, "minY" : 489, "maxY" : 576, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1681, "y" : 489 }, "to" : { "x" : 1679, "y" : 531 } }, { "from" : { "x" : 1679, "y" : 531 }, "to" : { "x" : 1680, "y" : 576 } } ], "reactionShape" : { "a" : { "x" : 1673, "y" : 525 }, "b" : { "x" : 1685, "y" : 537 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1679, "y" : 531 } }, "inputs" : [ { "id" : 102778, "points" : [ { "x" : 1680, "y" : 442 } ] }, { "id" : 102779, "points" : [ { "x" : 1656, "y" : 472 } ] }, { "id" : 102780, "points" : [ { "x" : 1700, "y" : 475 } ] } ], "outputs" : [ { "id" : 102781, "points" : [ { "x" : 1651, "y" : 589 } ] }, { "id" : 102782, "points" : [ { "x" : 1679, "y" : 629 } ] } ], "catalysts" : [ { "id" : 102783, "points" : [ { "x" : 1640, "y" : 531 } ] } ] }, { "id" : 102873, "reactomeId" : 10243169, "displayName" : "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 484, "y" : 631 }, "minX" : 478, "maxX" : 490, "minY" : 598, "maxY" : 668, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 485, "y" : 598 }, "to" : { "x" : 484, "y" : 631 } }, { "from" : { "x" : 484, "y" : 631 }, "to" : { "x" : 484, "y" : 668 } } ], "reactionShape" : { "a" : { "x" : 478, "y" : 625 }, "b" : { "x" : 490, "y" : 637 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 484, "y" : 631 } }, "inputs" : [ { "id" : 102768, "points" : [ { "x" : 485, "y" : 536 } ] }, { "id" : 102874, "points" : [ { "x" : 510, "y" : 582 } ] }, { "id" : 102863, "points" : [ { "x" : 382, "y" : 579 } ] } ], "outputs" : [ { "id" : 102787, "points" : [ { "x" : 484, "y" : 708 } ] }, { "id" : 102875, "points" : [ { "x" : 521, "y" : 676 } ] } ], "catalysts" : [ { "id" : 102841, "points" : [ { "x" : 428, "y" : 631 } ] } ] }, { "id" : 102808, "reactomeId" : 10243151, "displayName" : "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 745, "y" : 514 }, "minX" : 705, "maxX" : 794, "minY" : 508, "maxY" : 520, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 794, "y" : 514 }, "to" : { "x" : 745, "y" : 514 } }, { "from" : { "x" : 745, "y" : 514 }, "to" : { "x" : 705, "y" : 514 } } ], "reactionShape" : { "a" : { "x" : 739, "y" : 508 }, "b" : { "x" : 751, "y" : 520 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 745, "y" : 514 } }, "inputs" : [ { "id" : 102809, "points" : [ { "x" : 992, "y" : 514 } ] }, { "id" : 102810, "points" : [ { "x" : 821, "y" : 492 } ] }, { "id" : 102811, "points" : [ { "x" : 803, "y" : 547 } ] }, { "id" : 102812, "points" : [ { "x" : 835, "y" : 532 } ] } ], "outputs" : [ { "id" : 102813, "points" : [ { "x" : 684, "y" : 542 } ] }, { "id" : 102768, "points" : [ { "x" : 516, "y" : 516 } ] }, { "id" : 102814, "points" : [ { "x" : 683, "y" : 494 } ] }, { "id" : 102815, "points" : [ { "x" : 654, "y" : 535 } ] } ], "catalysts" : [ { "id" : 102816, "points" : [ { "x" : 745, "y" : 456 } ] } ], "activators" : [ { "id" : 102817, "points" : [ { "x" : 745, "y" : 562 } ] } ] }, { "id" : 102842, "reactomeId" : 10309822, "displayName" : "NMRK1 phosphorylates NR to yield NMN", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 141, "y" : 964 }, "minX" : 99, "maxX" : 179, "minY" : 958, "maxY" : 970, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 99, "y" : 964 }, "to" : { "x" : 141, "y" : 964 } }, { "from" : { "x" : 141, "y" : 964 }, "to" : { "x" : 179, "y" : 965 } } ], "reactionShape" : { "a" : { "x" : 135, "y" : 958 }, "b" : { "x" : 147, "y" : 970 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 141, "y" : 964 } }, "inputs" : [ { "id" : 102843, "points" : [ { "x" : 57, "y" : 956 } ] }, { "id" : 102844, "points" : [ { "x" : 63, "y" : 991 } ] } ], "outputs" : [ { "id" : 102837, "points" : [ { "x" : 242, "y" : 965 } ] }, { "id" : 102845, "points" : [ { "x" : 228, "y" : 931 } ] }, { "id" : 102846, "points" : [ { "x" : 232, "y" : 1008 } ] } ], "catalysts" : [ { "id" : 102847, "points" : [ { "x" : 141, "y" : 934 } ] } ] }, { "id" : 102876, "reactomeId" : 10327602, "displayName" : "SLC25A51 mediates mitochondrial uptake of NAD+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1381, "y" : 737 }, "minX" : 1344, "maxX" : 1432, "minY" : 731, "maxY" : 743, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1344, "y" : 737 }, "to" : { "x" : 1381, "y" : 737 } }, { "from" : { "x" : 1381, "y" : 737 }, "to" : { "x" : 1432, "y" : 738 } } ], "endShape" : { "a" : { "x" : 1425, "y" : 742 }, "b" : { "x" : 1432, "y" : 738 }, "c" : { "x" : 1425, "y" : 734 }, "type" : "ARROW", "centre" : { "x" : 1425, "y" : 734 } }, "reactionShape" : { "a" : { "x" : 1375, "y" : 731 }, "b" : { "x" : 1387, "y" : 743 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1381, "y" : 737 } }, "inputs" : [ { "id" : 102877 } ], "outputs" : [ { "id" : 102867 } ], "catalysts" : [ { "id" : 102878, "points" : [ { "x" : 1380, "y" : 709 } ] } ] }, { "id" : 102879, "reactomeId" : 10287908, "displayName" : "NNMT transfers CH3 from SAM to NAM to form MNA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1161, "y" : 961 }, "minX" : 1117, "maxX" : 1212, "minY" : 955, "maxY" : 967, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1117, "y" : 961 }, "to" : { "x" : 1161, "y" : 961 } }, { "from" : { "x" : 1161, "y" : 961 }, "to" : { "x" : 1212, "y" : 961 } } ], "reactionShape" : { "a" : { "x" : 1155, "y" : 955 }, "b" : { "x" : 1167, "y" : 967 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1161, "y" : 961 } }, "inputs" : [ { "id" : 102802, "points" : [ { "x" : 1040, "y" : 961 } ] }, { "id" : 102880, "points" : [ { "x" : 1103, "y" : 984 } ] } ], "outputs" : [ { "id" : 102881, "points" : [ { "x" : 1258, "y" : 961 } ] }, { "id" : 102882, "points" : [ { "x" : 1226, "y" : 985 } ] } ], "catalysts" : [ { "id" : 102883, "points" : [ { "x" : 1160, "y" : 924 } ] } ] } ], "compartments" : [ { "id" : 102912, "reactomeId" : 17963, "displayName" : "Golgi lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 283, "y" : 635 }, "minX" : 213, "maxX" : 353, "minY" : 608, "maxY" : 662, "prop" : { "x" : 213, "y" : 608, "width" : 140, "height" : 54 }, "textPosition" : { "x" : 239, "y" : 618 }, "insets" : { "x" : 223, "y" : 618, "width" : 120, "height" : 34 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 102841 ] }, { "id" : 102905, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1116, "y" : 740 }, "minX" : 0, "maxX" : 2232, "minY" : 224, "maxY" : 1256, "prop" : { "x" : 0, "y" : 224, "width" : 2232, "height" : 1032 }, "textPosition" : { "x" : 710, "y" : 347 }, "insets" : { "x" : 10, "y" : 234, "width" : 2212, "height" : 1012 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 102906, 102907, 102908, 102763, 102762, 102764, 102769, 102787, 102785, 102786, 102790, 102794, 102789, 102791, 102784, 102792, 102796, 102795, 102800, 102798, 102802, 102809, 102807, 102803, 102805, 102801, 102816, 102817, 102812, 102808, 102815, 102881, 102883, 102882, 102880, 102911, 102912, 102767, 102788, 102766, 102824, 102825, 102829, 102830, 102834, 102833, 102915, 102835, 102862, 102864, 102836, 102837, 102842, 102843, 102847, 102846, 102854, 102860, 102861, 102913, 102916, 102845, 102865, 102844, 102863, 102840, 102765, 102768, 102806, 102873, 102874, 102875, 102793, 102797, 102799, 102838, 102839, 102877, 102804, 102826, 102810, 102811, 102813, 102814, 102879 ] }, { "id" : 102907, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1948, "y" : 497 }, "minX" : 1784, "maxX" : 2113, "minY" : 399, "maxY" : 596, "prop" : { "x" : 1784, "y" : 399, "width" : 329, "height" : 197 }, "textPosition" : { "x" : 1794, "y" : 554 }, "insets" : { "x" : 1794, "y" : 409, "width" : 309, "height" : 177 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 102770, 102771, 102774, 102776, 102775, 102772, 102773 ] }, { "id" : 102906, "reactomeId" : 5460, "displayName" : "mitochondrial matrix", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1573, "y" : 609 }, "minX" : 1376, "maxX" : 1770, "minY" : 313, "maxY" : 906, "prop" : { "x" : 1376, "y" : 313, "width" : 394, "height" : 593 }, "textPosition" : { "x" : 1579, "y" : 857 }, "insets" : { "x" : 1386, "y" : 323, "width" : 374, "height" : 573 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 102885, 102886, 102887, 102889, 102890, 102871, 102891, 102892, 102870, 102783, 102777, 102782, 102778, 102869, 102866, 102872, 102868, 102867, 102781, 102779, 102780, 102878, 102876, 102888 ] }, { "id" : 102911, "reactomeId" : 17951, "displayName" : "peroxisomal matrix", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1981, "y" : 763 }, "minX" : 1783, "maxX" : 2179, "minY" : 673, "maxY" : 854, "prop" : { "x" : 1783, "y" : 673, "width" : 396, "height" : 181 }, "textPosition" : { "x" : 1796, "y" : 808 }, "insets" : { "x" : 1793, "y" : 683, "width" : 376, "height" : 161 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 102894, 102898, 102897, 102899, 102896, 102895, 102893 ] } ], "notes" : [ ], "links" : [ { "id" : 102915, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1098, "y" : 441 }, "minX" : 1033, "maxX" : 1164, "minY" : 385, "maxY" : 497, "segments" : [ { "from" : { "x" : 1033, "y" : 497 }, "to" : { "x" : 1164, "y" : 385 } } ], "reactionShape" : { "a" : { "x" : 1092, "y" : 435 }, "b" : { "x" : 1104, "y" : 447 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1098, "y" : 441 } }, "inputs" : [ { "id" : 102809 } ], "outputs" : [ { "id" : 102833 } ] }, { "id" : 102914, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1083, "y" : 159 }, "minX" : 1040, "maxX" : 1127, "minY" : 153, "maxY" : 165, "segments" : [ { "from" : { "x" : 1040, "y" : 159 }, "to" : { "x" : 1127, "y" : 159 } } ], "reactionShape" : { "a" : { "x" : 1077, "y" : 153 }, "b" : { "x" : 1089, "y" : 165 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1083, "y" : 159 } }, "inputs" : [ { "id" : 102827 } ], "outputs" : [ { "id" : 102831 } ] }, { "id" : 102916, "renderableClass" : "Interaction", "position" : { "x" : 265, "y" : 303 }, "minX" : 229, "maxX" : 302, "minY" : 297, "maxY" : 309, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 229, "y" : 303 }, "to" : { "x" : 302, "y" : 303 } } ], "endShape" : { "a" : { "x" : 295, "y" : 307 }, "b" : { "x" : 302, "y" : 303 }, "c" : { "x" : 295, "y" : 299 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 295, "y" : 299 } }, "reactionShape" : { "a" : { "x" : 259, "y" : 297 }, "b" : { "x" : 271, "y" : 309 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 265, "y" : 303 } }, "inputs" : [ { "id" : 102913 } ], "outputs" : [ { "id" : 102908 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 2232, "minY" : 0, "maxY" : 1256, "disease" : false }