{
  "dbId" : 10995733,
  "stableId" : "R-CEL-8852135",
  "displayName" : "Protein ubiquitination",
  "nodes" : [ {
    "id" : 12544,
    "reactomeId" : 10980499,
    "displayName" : "E2 ubiquitin conjugating enzyme (UBA1 substrate)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 676,
      "y" : 376
    },
    "minX" : 539,
    "maxX" : 766,
    "minY" : 359,
    "maxY" : 393,
    "prop" : {
      "x" : 587,
      "y" : 359,
      "width" : 179,
      "height" : 34
    },
    "textPosition" : {
      "x" : 593,
      "y" : 359
    },
    "connectors" : [ {
      "edgeId" : 12543,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 581,
          "y" : 383
        },
        "to" : {
          "x" : 539,
          "y" : 387
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12545,
    "reactomeId" : 10980605,
    "displayName" : "Ub:E2 (UBA1 substrate)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 685,
      "y" : 443
    },
    "minX" : 540,
    "maxX" : 779,
    "minY" : 424,
    "maxY" : 456,
    "prop" : {
      "x" : 597,
      "y" : 430,
      "width" : 176,
      "height" : 26
    },
    "textPosition" : {
      "x" : 606,
      "y" : 435
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 773,
          "y" : 430
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 773,
          "y" : 430
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12543,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 594,
          "y" : 432
        },
        "to" : {
          "x" : 540,
          "y" : 425
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 587,
          "y" : 435
        },
        "b" : {
          "x" : 594,
          "y" : 432
        },
        "c" : {
          "x" : 588,
          "y" : 427
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 588,
          "y" : 427
        }
      }
    } ]
  }, {
    "id" : 12547,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 154,
      "y" : 640
    },
    "minX" : 134,
    "maxX" : 243,
    "minY" : 616,
    "maxY" : 655,
    "prop" : {
      "x" : 134,
      "y" : 625,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 138,
      "y" : 629
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 169,
          "y" : 630
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 169,
          "y" : 630
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12546,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 177,
          "y" : 634
        },
        "to" : {
          "x" : 243,
          "y" : 616
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12548,
    "reactomeId" : 10914410,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 150,
      "y" : 562
    },
    "minX" : 108,
    "maxX" : 773,
    "minY" : 547,
    "maxY" : 621,
    "prop" : {
      "x" : 108,
      "y" : 547,
      "width" : 84,
      "height" : 31
    },
    "textPosition" : {
      "x" : 137,
      "y" : 552
    },
    "connectors" : [ {
      "edgeId" : 12546,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 176,
          "y" : 584
        },
        "to" : {
          "x" : 243,
          "y" : 616
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 12555,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 198,
          "y" : 562
        },
        "to" : {
          "x" : 745,
          "y" : 565
        }
      }, {
        "from" : {
          "x" : 745,
          "y" : 565
        },
        "to" : {
          "x" : 773,
          "y" : 621
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12549,
    "reactomeId" : 10980410,
    "displayName" : "uba-1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 138,
      "y" : 601
    },
    "minX" : 113,
    "maxX" : 243,
    "minY" : 584,
    "maxY" : 616,
    "prop" : {
      "x" : 113,
      "y" : 590,
      "width" : 51,
      "height" : 22
    },
    "textPosition" : {
      "x" : 116,
      "y" : 590
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 164,
          "y" : 590
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 164,
          "y" : 590
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12546,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 167,
          "y" : 604
        },
        "to" : {
          "x" : 243,
          "y" : 616
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12550,
    "reactomeId" : 113541,
    "displayName" : "PPi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 378,
      "y" : 593
    },
    "minX" : 305,
    "maxX" : 402,
    "minY" : 577,
    "maxY" : 613,
    "prop" : {
      "x" : 356,
      "y" : 578,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 365,
      "y" : 583
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 396,
          "y" : 583
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 396,
          "y" : 583
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12546,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 353,
          "y" : 599
        },
        "to" : {
          "x" : 305,
          "y" : 613
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 347,
          "y" : 605
        },
        "b" : {
          "x" : 353,
          "y" : 599
        },
        "c" : {
          "x" : 345,
          "y" : 597
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 345,
          "y" : 597
        }
      }
    } ]
  }, {
    "id" : 12551,
    "reactomeId" : 10980495,
    "displayName" : "UBA1:ubiquitin adenylate",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 445,
      "y" : 631
    },
    "minX" : 305,
    "maxX" : 1071,
    "minY" : 612,
    "maxY" : 715,
    "prop" : {
      "x" : 352,
      "y" : 620,
      "width" : 187,
      "height" : 23
    },
    "textPosition" : {
      "x" : 363,
      "y" : 622
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 539,
          "y" : 620
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 539,
          "y" : 620
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12546,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 355,
          "y" : 617
        },
        "to" : {
          "x" : 305,
          "y" : 613
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 348,
          "y" : 620
        },
        "b" : {
          "x" : 355,
          "y" : 617
        },
        "c" : {
          "x" : 348,
          "y" : 612
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 348,
          "y" : 612
        }
      }
    }, {
      "edgeId" : 12552,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 12559,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 451,
          "y" : 646
        },
        "to" : {
          "x" : 493,
          "y" : 715
        }
      }, {
        "from" : {
          "x" : 493,
          "y" : 715
        },
        "to" : {
          "x" : 1071,
          "y" : 715
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 458,
          "y" : 650
        },
        "b" : {
          "x" : 451,
          "y" : 646
        },
        "c" : {
          "x" : 451,
          "y" : 654
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 451,
          "y" : 654
        }
      }
    } ]
  }, {
    "id" : 12553,
    "reactomeId" : 164121,
    "displayName" : "AMP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 659,
      "y" : 592
    },
    "minX" : 600,
    "maxX" : 681,
    "minY" : 576,
    "maxY" : 632,
    "prop" : {
      "x" : 639,
      "y" : 577,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 642,
      "y" : 581
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 675,
          "y" : 582
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 675,
          "y" : 582
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12552,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 636,
          "y" : 605
        },
        "to" : {
          "x" : 600,
          "y" : 632
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 633,
          "y" : 612
        },
        "b" : {
          "x" : 636,
          "y" : 605
        },
        "c" : {
          "x" : 628,
          "y" : 606
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 628,
          "y" : 606
        }
      }
    } ]
  }, {
    "id" : 12554,
    "reactomeId" : 10980609,
    "displayName" : "Ub-Cys632-UBA1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 694,
      "y" : 632
    },
    "minX" : 600,
    "maxX" : 773,
    "minY" : 615,
    "maxY" : 643,
    "prop" : {
      "x" : 635,
      "y" : 621,
      "width" : 118,
      "height" : 22
    },
    "textPosition" : {
      "x" : 638,
      "y" : 622
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 753,
          "y" : 621
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 753,
          "y" : 621
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12552,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 632,
          "y" : 632
        },
        "to" : {
          "x" : 600,
          "y" : 632
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 625,
          "y" : 636
        },
        "b" : {
          "x" : 632,
          "y" : 632
        },
        "c" : {
          "x" : 625,
          "y" : 628
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 625,
          "y" : 628
        }
      }
    }, {
      "edgeId" : 12555,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 756,
          "y" : 623
        },
        "to" : {
          "x" : 773,
          "y" : 621
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12556,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 727,
      "y" : 598
    },
    "minX" : 707,
    "maxX" : 773,
    "minY" : 582,
    "maxY" : 621,
    "prop" : {
      "x" : 707,
      "y" : 583,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 711,
      "y" : 587
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 742,
          "y" : 588
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 742,
          "y" : 588
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12555,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 750,
          "y" : 608
        },
        "to" : {
          "x" : 773,
          "y" : 621
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12557,
    "reactomeId" : 10980611,
    "displayName" : "Ub-Cys632-UBA1:ubiquitin adenylate",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1062,
      "y" : 631
    },
    "minX" : 834,
    "maxX" : 1191,
    "minY" : 614,
    "maxY" : 665,
    "prop" : {
      "x" : 940,
      "y" : 620,
      "width" : 245,
      "height" : 23
    },
    "textPosition" : {
      "x" : 945,
      "y" : 622
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1185,
          "y" : 620
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1185,
          "y" : 620
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12555,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 937,
          "y" : 631
        },
        "to" : {
          "x" : 834,
          "y" : 631
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 930,
          "y" : 635
        },
        "b" : {
          "x" : 937,
          "y" : 631
        },
        "c" : {
          "x" : 930,
          "y" : 627
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 930,
          "y" : 627
        }
      }
    }, {
      "edgeId" : 12559,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1064,
          "y" : 646
        },
        "to" : {
          "x" : 1069,
          "y" : 665
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12558,
    "reactomeId" : 113541,
    "displayName" : "PPi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 887,
      "y" : 593
    },
    "minX" : 834,
    "maxX" : 911,
    "minY" : 577,
    "maxY" : 631,
    "prop" : {
      "x" : 865,
      "y" : 578,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 874,
      "y" : 583
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 905,
          "y" : 583
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 905,
          "y" : 583
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12555,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 862,
          "y" : 609
        },
        "to" : {
          "x" : 834,
          "y" : 631
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 859,
          "y" : 616
        },
        "b" : {
          "x" : 862,
          "y" : 609
        },
        "c" : {
          "x" : 854,
          "y" : 610
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 854,
          "y" : 610
        }
      }
    } ]
  }, {
    "id" : 12560,
    "reactomeId" : 10980630,
    "displayName" : "E2 ubiquitin conjugating enzyme (UBA1 substrate)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1302,
      "y" : 645
    },
    "minX" : 1069,
    "maxX" : 1402,
    "minY" : 627,
    "maxY" : 665,
    "prop" : {
      "x" : 1202,
      "y" : 627,
      "width" : 200,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1219,
      "y" : 628
    },
    "connectors" : [ {
      "edgeId" : 12559,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1196,
          "y" : 653
        },
        "to" : {
          "x" : 1069,
          "y" : 665
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12561,
    "reactomeId" : 10980652,
    "displayName" : "Ub:E2 (UBA1 substrate)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1220,
      "y" : 742
    },
    "minX" : 1071,
    "maxX" : 1314,
    "minY" : 715,
    "maxY" : 755,
    "prop" : {
      "x" : 1132,
      "y" : 729,
      "width" : 176,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1141,
      "y" : 734
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1308,
          "y" : 729
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1308,
          "y" : 729
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12559,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1148,
          "y" : 726
        },
        "to" : {
          "x" : 1071,
          "y" : 715
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1141,
          "y" : 729
        },
        "b" : {
          "x" : 1148,
          "y" : 726
        },
        "c" : {
          "x" : 1142,
          "y" : 721
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1142,
          "y" : 721
        }
      }
    } ]
  }, {
    "id" : 12514,
    "reactomeId" : 10980716,
    "displayName" : "UBB",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 83,
      "y" : 29
    },
    "minX" : 53,
    "maxX" : 120,
    "minY" : 12,
    "maxY" : 40,
    "prop" : {
      "x" : 53,
      "y" : 18,
      "width" : 61,
      "height" : 22
    },
    "textPosition" : {
      "x" : 67,
      "y" : 18
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 114,
          "y" : 18
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 114,
          "y" : 18
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12513,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12515,
    "reactomeId" : 10914448,
    "displayName" : "UBB(153-228)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 68,
      "y" : 189
    },
    "minX" : 17,
    "maxX" : 125,
    "minY" : 97,
    "maxY" : 202,
    "prop" : {
      "x" : 17,
      "y" : 176,
      "width" : 102,
      "height" : 26
    },
    "textPosition" : {
      "x" : 20,
      "y" : 178
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 119,
          "y" : 176
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 119,
          "y" : 176
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12513,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 70,
          "y" : 173
        },
        "to" : {
          "x" : 85,
          "y" : 97
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 67,
          "y" : 165
        },
        "b" : {
          "x" : 70,
          "y" : 173
        },
        "c" : {
          "x" : 75,
          "y" : 167
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 75,
          "y" : 167
        }
      }
    } ]
  }, {
    "id" : 12516,
    "reactomeId" : 10914446,
    "displayName" : "UBB(77-152)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 135,
      "y" : 157
    },
    "minX" : 85,
    "maxX" : 190,
    "minY" : 97,
    "maxY" : 170,
    "prop" : {
      "x" : 87,
      "y" : 144,
      "width" : 97,
      "height" : 26
    },
    "textPosition" : {
      "x" : 92,
      "y" : 146
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 184,
          "y" : 144
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 184,
          "y" : 144
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12513,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 124,
          "y" : 141
        },
        "to" : {
          "x" : 85,
          "y" : 97
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 116,
          "y" : 138
        },
        "b" : {
          "x" : 124,
          "y" : 141
        },
        "c" : {
          "x" : 122,
          "y" : 133
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 122,
          "y" : 133
        }
      }
    } ]
  }, {
    "id" : 12517,
    "reactomeId" : 10914444,
    "displayName" : "UBB(1-76)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 193,
      "y" : 128
    },
    "minX" : 85,
    "maxX" : 248,
    "minY" : 97,
    "maxY" : 140,
    "prop" : {
      "x" : 144,
      "y" : 116,
      "width" : 98,
      "height" : 24
    },
    "textPosition" : {
      "x" : 157,
      "y" : 117
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 242,
          "y" : 116
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 242,
          "y" : 116
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12513,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 151,
          "y" : 113
        },
        "to" : {
          "x" : 85,
          "y" : 97
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 143,
          "y" : 115
        },
        "b" : {
          "x" : 151,
          "y" : 113
        },
        "c" : {
          "x" : 145,
          "y" : 107
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 145,
          "y" : 107
        }
      }
    } ]
  }, {
    "id" : 12518,
    "reactomeId" : 10970461,
    "displayName" : "USP5",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 398,
      "y" : 67
    },
    "minX" : 92,
    "maxX" : 691,
    "minY" : 47,
    "maxY" : 81,
    "prop" : {
      "x" : 343,
      "y" : 53,
      "width" : 111,
      "height" : 28
    },
    "textPosition" : {
      "x" : 378,
      "y" : 56
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 454,
          "y" : 53
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 454,
          "y" : 53
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12513,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 337,
          "y" : 68
        },
        "to" : {
          "x" : 100,
          "y" : 73
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 96,
          "y" : 73
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 96,
          "y" : 73
        }
      }
    }, {
      "edgeId" : 12519,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 460,
          "y" : 67
        },
        "to" : {
          "x" : 683,
          "y" : 68
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 687,
          "y" : 68
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 687,
          "y" : 68
        }
      }
    } ]
  }, {
    "id" : 12520,
    "reactomeId" : 10980711,
    "displayName" : "Homologues of UBC",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 697,
      "y" : 28
    },
    "minX" : 668,
    "maxX" : 727,
    "minY" : 17,
    "maxY" : 39,
    "prop" : {
      "x" : 668,
      "y" : 17,
      "width" : 59,
      "height" : 22
    },
    "textPosition" : {
      "x" : 668,
      "y" : 4
    },
    "connectors" : [ {
      "edgeId" : 12519,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12521,
    "reactomeId" : 10914472,
    "displayName" : "Homologues of UBC(229-304)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1152,
      "y" : 90
    },
    "minX" : 699,
    "maxX" : 1200,
    "minY" : 79,
    "maxY" : 102,
    "prop" : {
      "x" : 1104,
      "y" : 79,
      "width" : 96,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1107,
      "y" : 66
    },
    "connectors" : [ {
      "edgeId" : 12519,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1101,
          "y" : 90
        },
        "to" : {
          "x" : 699,
          "y" : 93
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1094,
          "y" : 94
        },
        "b" : {
          "x" : 1101,
          "y" : 90
        },
        "c" : {
          "x" : 1094,
          "y" : 86
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1094,
          "y" : 86
        }
      }
    } ]
  }, {
    "id" : 12522,
    "reactomeId" : 10914496,
    "displayName" : "Homologues of UBC(533-608)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1036,
      "y" : 110
    },
    "minX" : 699,
    "maxX" : 1084,
    "minY" : 93,
    "maxY" : 122,
    "prop" : {
      "x" : 988,
      "y" : 98,
      "width" : 96,
      "height" : 24
    },
    "textPosition" : {
      "x" : 991,
      "y" : 86
    },
    "connectors" : [ {
      "edgeId" : 12519,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 985,
          "y" : 107
        },
        "to" : {
          "x" : 699,
          "y" : 93
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 978,
          "y" : 111
        },
        "b" : {
          "x" : 985,
          "y" : 107
        },
        "c" : {
          "x" : 978,
          "y" : 103
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 978,
          "y" : 103
        }
      }
    } ]
  }, {
    "id" : 12523,
    "reactomeId" : 10914490,
    "displayName" : "Homologues of UBC(457-532)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 934,
      "y" : 126
    },
    "minX" : 699,
    "maxX" : 983,
    "minY" : 93,
    "maxY" : 138,
    "prop" : {
      "x" : 885,
      "y" : 115,
      "width" : 98,
      "height" : 23
    },
    "textPosition" : {
      "x" : 889,
      "y" : 102
    },
    "connectors" : [ {
      "edgeId" : 12519,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 882,
          "y" : 119
        },
        "to" : {
          "x" : 699,
          "y" : 93
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 875,
          "y" : 122
        },
        "b" : {
          "x" : 882,
          "y" : 119
        },
        "c" : {
          "x" : 876,
          "y" : 114
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 876,
          "y" : 114
        }
      }
    } ]
  }, {
    "id" : 12524,
    "reactomeId" : 10914460,
    "displayName" : "Homologues of UBC(77-152)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 837,
      "y" : 134
    },
    "minX" : 699,
    "maxX" : 881,
    "minY" : 93,
    "maxY" : 146,
    "prop" : {
      "x" : 794,
      "y" : 122,
      "width" : 87,
      "height" : 24
    },
    "textPosition" : {
      "x" : 793,
      "y" : 110
    },
    "connectors" : [ {
      "edgeId" : 12519,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 796,
          "y" : 119
        },
        "to" : {
          "x" : 699,
          "y" : 93
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 788,
          "y" : 121
        },
        "b" : {
          "x" : 796,
          "y" : 119
        },
        "c" : {
          "x" : 790,
          "y" : 113
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 790,
          "y" : 113
        }
      }
    } ]
  }, {
    "id" : 12525,
    "reactomeId" : 10914454,
    "displayName" : "Homologues of UBC(1-76)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 753,
      "y" : 134
    },
    "minX" : 699,
    "maxX" : 791,
    "minY" : 93,
    "maxY" : 146,
    "prop" : {
      "x" : 715,
      "y" : 122,
      "width" : 76,
      "height" : 24
    },
    "textPosition" : {
      "x" : 717,
      "y" : 110
    },
    "connectors" : [ {
      "edgeId" : 12519,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 737,
          "y" : 119
        },
        "to" : {
          "x" : 699,
          "y" : 93
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 729,
          "y" : 118
        },
        "b" : {
          "x" : 737,
          "y" : 119
        },
        "c" : {
          "x" : 734,
          "y" : 112
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 734,
          "y" : 112
        }
      }
    } ]
  }, {
    "id" : 12526,
    "reactomeId" : 10914484,
    "displayName" : "Homologues of UBC(381-456)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 660,
      "y" : 135
    },
    "minX" : 613,
    "maxX" : 708,
    "minY" : 93,
    "maxY" : 147,
    "prop" : {
      "x" : 613,
      "y" : 124,
      "width" : 95,
      "height" : 23
    },
    "textPosition" : {
      "x" : 615,
      "y" : 111
    },
    "connectors" : [ {
      "edgeId" : 12519,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 670,
          "y" : 121
        },
        "to" : {
          "x" : 699,
          "y" : 93
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 672,
          "y" : 113
        },
        "b" : {
          "x" : 670,
          "y" : 121
        },
        "c" : {
          "x" : 678,
          "y" : 119
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 678,
          "y" : 119
        }
      }
    } ]
  }, {
    "id" : 12527,
    "reactomeId" : 10914478,
    "displayName" : "Homologues of UBC(305-380)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 553,
      "y" : 134
    },
    "minX" : 504,
    "maxX" : 699,
    "minY" : 93,
    "maxY" : 147,
    "prop" : {
      "x" : 504,
      "y" : 122,
      "width" : 98,
      "height" : 25
    },
    "textPosition" : {
      "x" : 508,
      "y" : 110
    },
    "connectors" : [ {
      "edgeId" : 12519,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 597,
          "y" : 119
        },
        "to" : {
          "x" : 699,
          "y" : 93
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 603,
          "y" : 113
        },
        "b" : {
          "x" : 597,
          "y" : 119
        },
        "c" : {
          "x" : 605,
          "y" : 121
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 605,
          "y" : 121
        }
      }
    } ]
  }, {
    "id" : 12528,
    "reactomeId" : 10914466,
    "displayName" : "Homologues of UBC(153-228)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 430,
      "y" : 125
    },
    "minX" : 383,
    "maxX" : 699,
    "minY" : 93,
    "maxY" : 138,
    "prop" : {
      "x" : 383,
      "y" : 113,
      "width" : 95,
      "height" : 25
    },
    "textPosition" : {
      "x" : 385,
      "y" : 101
    },
    "connectors" : [ {
      "edgeId" : 12519,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 481,
          "y" : 119
        },
        "to" : {
          "x" : 699,
          "y" : 93
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 487,
          "y" : 114
        },
        "b" : {
          "x" : 481,
          "y" : 119
        },
        "c" : {
          "x" : 488,
          "y" : 122
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 488,
          "y" : 122
        }
      }
    } ]
  }, {
    "id" : 12529,
    "reactomeId" : 10914502,
    "displayName" : "Homologues of UBC(609-684)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 309,
      "y" : 115
    },
    "minX" : 262,
    "maxX" : 699,
    "minY" : 93,
    "maxY" : 128,
    "prop" : {
      "x" : 262,
      "y" : 103,
      "width" : 95,
      "height" : 25
    },
    "textPosition" : {
      "x" : 264,
      "y" : 91
    },
    "connectors" : [ {
      "edgeId" : 12519,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 360,
          "y" : 112
        },
        "to" : {
          "x" : 699,
          "y" : 93
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 367,
          "y" : 108
        },
        "b" : {
          "x" : 360,
          "y" : 112
        },
        "c" : {
          "x" : 367,
          "y" : 116
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 367,
          "y" : 116
        }
      }
    } ]
  }, {
    "id" : 12531,
    "reactomeId" : 10914504,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 760,
      "y" : 235
    },
    "minX" : 166,
    "maxX" : 816,
    "minY" : 217,
    "maxY" : 327,
    "prop" : {
      "x" : 705,
      "y" : 217,
      "width" : 111,
      "height" : 37
    },
    "textPosition" : {
      "x" : 748,
      "y" : 225
    },
    "connectors" : [ {
      "edgeId" : 12530,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 699,
          "y" : 233
        },
        "to" : {
          "x" : 191,
          "y" : 221
        }
      }, {
        "from" : {
          "x" : 191,
          "y" : 221
        },
        "to" : {
          "x" : 166,
          "y" : 253
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 12539,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 699,
          "y" : 239
        },
        "to" : {
          "x" : 429,
          "y" : 262
        }
      }, {
        "from" : {
          "x" : 429,
          "y" : 262
        },
        "to" : {
          "x" : 428,
          "y" : 327
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12532,
    "reactomeId" : 10945475,
    "displayName" : "uba-1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 95,
      "y" : 233
    },
    "minX" : 70,
    "maxX" : 166,
    "minY" : 215,
    "maxY" : 274,
    "prop" : {
      "x" : 70,
      "y" : 221,
      "width" : 50,
      "height" : 24
    },
    "textPosition" : {
      "x" : 73,
      "y" : 222
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 120,
          "y" : 221
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 120,
          "y" : 221
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12530,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 123,
          "y" : 240
        },
        "to" : {
          "x" : 166,
          "y" : 253
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 12530,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 114,
          "y" : 248
        },
        "to" : {
          "x" : 152,
          "y" : 268
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 155,
          "y" : 270
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 155,
          "y" : 270
        }
      }
    } ]
  }, {
    "id" : 12533,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 154,
      "y" : 218
    },
    "minX" : 130,
    "maxX" : 180,
    "minY" : 204,
    "maxY" : 253,
    "prop" : {
      "x" : 130,
      "y" : 205,
      "width" : 49,
      "height" : 27
    },
    "textPosition" : {
      "x" : 139,
      "y" : 208
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 174,
          "y" : 210
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 174,
          "y" : 210
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12530,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 158,
          "y" : 235
        },
        "to" : {
          "x" : 166,
          "y" : 253
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12534,
    "reactomeId" : 10980567,
    "displayName" : "UBA1:ubiquitin adenylate",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 126,
      "y" : 334
    },
    "minX" : 28,
    "maxX" : 540,
    "minY" : 296,
    "maxY" : 425,
    "prop" : {
      "x" : 34,
      "y" : 323,
      "width" : 185,
      "height" : 23
    },
    "textPosition" : {
      "x" : 44,
      "y" : 325
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 219,
          "y" : 323
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 219,
          "y" : 323
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12530,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 138,
          "y" : 320
        },
        "to" : {
          "x" : 166,
          "y" : 296
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 141,
          "y" : 312
        },
        "b" : {
          "x" : 138,
          "y" : 320
        },
        "c" : {
          "x" : 146,
          "y" : 319
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 146,
          "y" : 319
        }
      }
    }, {
      "edgeId" : 12536,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 12536,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 222,
          "y" : 334
        },
        "to" : {
          "x" : 234,
          "y" : 334
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 238,
          "y" : 335
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 238,
          "y" : 335
        }
      }
    }, {
      "edgeId" : 12543,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 79,
          "y" : 349
        },
        "to" : {
          "x" : 28,
          "y" : 358
        }
      }, {
        "from" : {
          "x" : 28,
          "y" : 358
        },
        "to" : {
          "x" : 32,
          "y" : 401
        }
      }, {
        "from" : {
          "x" : 32,
          "y" : 401
        },
        "to" : {
          "x" : 540,
          "y" : 425
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 73,
          "y" : 354
        },
        "b" : {
          "x" : 79,
          "y" : 349
        },
        "c" : {
          "x" : 71,
          "y" : 346
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 71,
          "y" : 346
        }
      }
    } ]
  }, {
    "id" : 12535,
    "reactomeId" : 111294,
    "displayName" : "PPi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 217,
      "y" : 304
    },
    "minX" : 166,
    "maxX" : 240,
    "minY" : 291,
    "maxY" : 316,
    "prop" : {
      "x" : 196,
      "y" : 292,
      "width" : 43,
      "height" : 24
    },
    "textPosition" : {
      "x" : 204,
      "y" : 293
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 234,
          "y" : 297
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 234,
          "y" : 297
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12530,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 193,
          "y" : 300
        },
        "to" : {
          "x" : 166,
          "y" : 296
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 186,
          "y" : 303
        },
        "b" : {
          "x" : 193,
          "y" : 300
        },
        "c" : {
          "x" : 187,
          "y" : 295
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 187,
          "y" : 295
        }
      }
    } ]
  }, {
    "id" : 12537,
    "reactomeId" : 10980501,
    "displayName" : "Ub-Cys632-UBA1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 348,
      "y" : 335
    },
    "minX" : 271,
    "maxX" : 455,
    "minY" : 318,
    "maxY" : 346,
    "prop" : {
      "x" : 289,
      "y" : 324,
      "width" : 119,
      "height" : 22
    },
    "textPosition" : {
      "x" : 293,
      "y" : 325
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 408,
          "y" : 324
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 408,
          "y" : 324
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12536,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 286,
          "y" : 334
        },
        "to" : {
          "x" : 271,
          "y" : 334
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 279,
          "y" : 338
        },
        "b" : {
          "x" : 286,
          "y" : 334
        },
        "c" : {
          "x" : 279,
          "y" : 330
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 279,
          "y" : 330
        }
      }
    }, {
      "edgeId" : 12539,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 411,
          "y" : 329
        },
        "to" : {
          "x" : 428,
          "y" : 327
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 12539,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 411,
          "y" : 335
        },
        "to" : {
          "x" : 447,
          "y" : 336
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 451,
          "y" : 336
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 451,
          "y" : 336
        }
      }
    } ]
  }, {
    "id" : 12538,
    "reactomeId" : 76577,
    "displayName" : "AMP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 299,
      "y" : 370
    },
    "minX" : 270,
    "maxX" : 329,
    "minY" : 334,
    "maxY" : 380,
    "prop" : {
      "x" : 270,
      "y" : 360,
      "width" : 58,
      "height" : 20
    },
    "textPosition" : {
      "x" : 282,
      "y" : 360
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 323,
          "y" : 365
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 323,
          "y" : 365
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12536,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 291,
          "y" : 357
        },
        "to" : {
          "x" : 271,
          "y" : 334
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 283,
          "y" : 354
        },
        "b" : {
          "x" : 291,
          "y" : 357
        },
        "c" : {
          "x" : 289,
          "y" : 349
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 289,
          "y" : 349
        }
      }
    } ]
  }, {
    "id" : 12540,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 362,
      "y" : 305
    },
    "minX" : 334,
    "maxX" : 428,
    "minY" : 292,
    "maxY" : 327,
    "prop" : {
      "x" : 334,
      "y" : 293,
      "width" : 57,
      "height" : 25
    },
    "textPosition" : {
      "x" : 347,
      "y" : 295
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 386,
          "y" : 298
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 386,
          "y" : 298
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12539,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 394,
          "y" : 314
        },
        "to" : {
          "x" : 428,
          "y" : 327
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12541,
    "reactomeId" : 10980565,
    "displayName" : "Ub-Cys632-UBA1:ubiquitin adenylate",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 639,
      "y" : 335
    },
    "minX" : 487,
    "maxX" : 768,
    "minY" : 318,
    "maxY" : 387,
    "prop" : {
      "x" : 517,
      "y" : 324,
      "width" : 245,
      "height" : 22
    },
    "textPosition" : {
      "x" : 522,
      "y" : 325
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 762,
          "y" : 324
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 762,
          "y" : 324
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12539,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 514,
          "y" : 335
        },
        "to" : {
          "x" : 487,
          "y" : 335
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 507,
          "y" : 339
        },
        "b" : {
          "x" : 514,
          "y" : 335
        },
        "c" : {
          "x" : 507,
          "y" : 331
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 507,
          "y" : 331
        }
      }
    }, {
      "edgeId" : 12543,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 594,
          "y" : 349
        },
        "to" : {
          "x" : 538,
          "y" : 360
        }
      }, {
        "from" : {
          "x" : 538,
          "y" : 360
        },
        "to" : {
          "x" : 539,
          "y" : 387
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12542,
    "reactomeId" : 111294,
    "displayName" : "PPi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 541,
      "y" : 300
    },
    "minX" : 487,
    "maxX" : 574,
    "minY" : 288,
    "maxY" : 335,
    "prop" : {
      "x" : 509,
      "y" : 289,
      "width" : 64,
      "height" : 22
    },
    "textPosition" : {
      "x" : 527,
      "y" : 289
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 568,
          "y" : 294
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 568,
          "y" : 294
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 12539,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 524,
          "y" : 314
        },
        "to" : {
          "x" : 487,
          "y" : 335
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 520,
          "y" : 321
        },
        "b" : {
          "x" : 524,
          "y" : 314
        },
        "c" : {
          "x" : 516,
          "y" : 314
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 516,
          "y" : 314
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 12513,
    "reactomeId" : 10980718,
    "displayName" : "OTULIN,USP5 cleaves UBB yielding ubiquitin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 84,
      "y" : 73
    },
    "minX" : 78,
    "maxX" : 90,
    "minY" : 43,
    "maxY" : 97,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 83,
        "y" : 43
      },
      "to" : {
        "x" : 84,
        "y" : 73
      }
    }, {
      "from" : {
        "x" : 84,
        "y" : 73
      },
      "to" : {
        "x" : 85,
        "y" : 97
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 78,
        "y" : 67
      },
      "b" : {
        "x" : 90,
        "y" : 79
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 84,
        "y" : 73
      }
    },
    "inputs" : [ {
      "id" : 12514
    } ],
    "outputs" : [ {
      "id" : 12515,
      "points" : [ {
        "x" : 70,
        "y" : 173
      } ]
    }, {
      "id" : 12516,
      "points" : [ {
        "x" : 124,
        "y" : 141
      } ]
    }, {
      "id" : 12517,
      "points" : [ {
        "x" : 151,
        "y" : 113
      } ]
    } ],
    "catalysts" : [ {
      "id" : 12518,
      "points" : [ {
        "x" : 337,
        "y" : 68
      } ]
    } ]
  }, {
    "id" : 12546,
    "reactomeId" : 10980497,
    "displayName" : "UBA1 adenylates ubiquitin in the nucleoplasm",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 278,
      "y" : 615
    },
    "minX" : 243,
    "maxX" : 305,
    "minY" : 609,
    "maxY" : 621,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 243,
        "y" : 616
      },
      "to" : {
        "x" : 278,
        "y" : 615
      }
    }, {
      "from" : {
        "x" : 278,
        "y" : 615
      },
      "to" : {
        "x" : 305,
        "y" : 613
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 278,
        "y" : 615
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 278,
        "y" : 615
      }
    },
    "inputs" : [ {
      "id" : 12547,
      "points" : [ {
        "x" : 177,
        "y" : 634
      } ]
    }, {
      "id" : 12548,
      "points" : [ {
        "x" : 176,
        "y" : 584
      } ]
    }, {
      "id" : 12549,
      "points" : [ {
        "x" : 167,
        "y" : 604
      } ]
    } ],
    "outputs" : [ {
      "id" : 12550,
      "points" : [ {
        "x" : 353,
        "y" : 599
      } ]
    }, {
      "id" : 12551,
      "points" : [ {
        "x" : 355,
        "y" : 617
      } ]
    } ]
  }, {
    "id" : 12530,
    "reactomeId" : 10980665,
    "displayName" : "UBA1 adenylates ubiquitin in the cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 166,
      "y" : 276
    },
    "minX" : 160,
    "maxX" : 172,
    "minY" : 253,
    "maxY" : 296,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 166,
        "y" : 253
      },
      "to" : {
        "x" : 166,
        "y" : 276
      }
    }, {
      "from" : {
        "x" : 166,
        "y" : 276
      },
      "to" : {
        "x" : 166,
        "y" : 296
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 160,
        "y" : 270
      },
      "b" : {
        "x" : 172,
        "y" : 282
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 166,
        "y" : 276
      }
    },
    "inputs" : [ {
      "id" : 12531,
      "points" : [ {
        "x" : 699,
        "y" : 233
      }, {
        "x" : 191,
        "y" : 221
      } ]
    }, {
      "id" : 12532,
      "points" : [ {
        "x" : 123,
        "y" : 240
      } ]
    }, {
      "id" : 12533,
      "points" : [ {
        "x" : 158,
        "y" : 235
      } ]
    } ],
    "outputs" : [ {
      "id" : 12534,
      "points" : [ {
        "x" : 138,
        "y" : 320
      } ]
    }, {
      "id" : 12535,
      "points" : [ {
        "x" : 193,
        "y" : 300
      } ]
    } ],
    "catalysts" : [ {
      "id" : 12532,
      "points" : [ {
        "x" : 114,
        "y" : 248
      } ]
    } ]
  }, {
    "id" : 12519,
    "reactomeId" : 10980714,
    "displayName" : "OTULIN,USP5 cleaves UBC yielding ubiquitin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 699,
      "y" : 68
    },
    "minX" : 693,
    "maxX" : 705,
    "minY" : 42,
    "maxY" : 93,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 697,
        "y" : 42
      },
      "to" : {
        "x" : 699,
        "y" : 68
      }
    }, {
      "from" : {
        "x" : 699,
        "y" : 68
      },
      "to" : {
        "x" : 699,
        "y" : 93
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 693,
        "y" : 62
      },
      "b" : {
        "x" : 705,
        "y" : 74
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 699,
        "y" : 68
      }
    },
    "inputs" : [ {
      "id" : 12520
    } ],
    "outputs" : [ {
      "id" : 12521,
      "points" : [ {
        "x" : 1101,
        "y" : 90
      } ]
    }, {
      "id" : 12522,
      "points" : [ {
        "x" : 985,
        "y" : 107
      } ]
    }, {
      "id" : 12523,
      "points" : [ {
        "x" : 882,
        "y" : 119
      } ]
    }, {
      "id" : 12524,
      "points" : [ {
        "x" : 796,
        "y" : 119
      } ]
    }, {
      "id" : 12525,
      "points" : [ {
        "x" : 737,
        "y" : 119
      } ]
    }, {
      "id" : 12526,
      "points" : [ {
        "x" : 670,
        "y" : 121
      } ]
    }, {
      "id" : 12527,
      "points" : [ {
        "x" : 597,
        "y" : 119
      } ]
    }, {
      "id" : 12528,
      "points" : [ {
        "x" : 481,
        "y" : 119
      } ]
    }, {
      "id" : 12529,
      "points" : [ {
        "x" : 360,
        "y" : 112
      } ]
    } ],
    "catalysts" : [ {
      "id" : 12518,
      "points" : [ {
        "x" : 460,
        "y" : 67
      } ]
    } ]
  }, {
    "id" : 12536,
    "reactomeId" : 10980662,
    "displayName" : "UBA1 conjugates ubiquitin to UBA1 in the cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 250,
      "y" : 335
    },
    "minX" : 222,
    "maxX" : 271,
    "minY" : 327,
    "maxY" : 341,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 222,
        "y" : 327
      },
      "to" : {
        "x" : 250,
        "y" : 335
      }
    }, {
      "from" : {
        "x" : 250,
        "y" : 335
      },
      "to" : {
        "x" : 271,
        "y" : 334
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 244,
        "y" : 329
      },
      "b" : {
        "x" : 256,
        "y" : 341
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 250,
        "y" : 335
      }
    },
    "inputs" : [ {
      "id" : 12534
    } ],
    "outputs" : [ {
      "id" : 12537,
      "points" : [ {
        "x" : 286,
        "y" : 334
      } ]
    }, {
      "id" : 12538,
      "points" : [ {
        "x" : 291,
        "y" : 357
      } ]
    } ],
    "catalysts" : [ {
      "id" : 12534,
      "points" : [ {
        "x" : 222,
        "y" : 334
      } ]
    } ]
  }, {
    "id" : 12552,
    "reactomeId" : 10980667,
    "displayName" : "UBA1 conjugates ubiquitin to UBA1 in the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 573,
      "y" : 631
    },
    "minX" : 542,
    "maxX" : 600,
    "minY" : 625,
    "maxY" : 637,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 542,
        "y" : 631
      },
      "to" : {
        "x" : 573,
        "y" : 631
      }
    }, {
      "from" : {
        "x" : 573,
        "y" : 631
      },
      "to" : {
        "x" : 600,
        "y" : 632
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 573,
        "y" : 631
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 573,
        "y" : 631
      }
    },
    "inputs" : [ {
      "id" : 12551
    } ],
    "outputs" : [ {
      "id" : 12553,
      "points" : [ {
        "x" : 636,
        "y" : 605
      } ]
    }, {
      "id" : 12554,
      "points" : [ {
        "x" : 632,
        "y" : 632
      } ]
    } ]
  }, {
    "id" : 12539,
    "reactomeId" : 10980659,
    "displayName" : "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 463,
      "y" : 336
    },
    "minX" : 428,
    "maxX" : 487,
    "minY" : 327,
    "maxY" : 342,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 428,
        "y" : 327
      },
      "to" : {
        "x" : 463,
        "y" : 336
      }
    }, {
      "from" : {
        "x" : 463,
        "y" : 336
      },
      "to" : {
        "x" : 487,
        "y" : 335
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 457,
        "y" : 330
      },
      "b" : {
        "x" : 469,
        "y" : 342
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 463,
        "y" : 336
      }
    },
    "inputs" : [ {
      "id" : 12531,
      "points" : [ {
        "x" : 699,
        "y" : 239
      }, {
        "x" : 429,
        "y" : 262
      } ]
    }, {
      "id" : 12540,
      "points" : [ {
        "x" : 394,
        "y" : 314
      } ]
    }, {
      "id" : 12537,
      "points" : [ {
        "x" : 411,
        "y" : 329
      } ]
    } ],
    "outputs" : [ {
      "id" : 12541,
      "points" : [ {
        "x" : 514,
        "y" : 335
      } ]
    }, {
      "id" : 12542,
      "points" : [ {
        "x" : 524,
        "y" : 314
      } ]
    } ],
    "catalysts" : [ {
      "id" : 12537,
      "points" : [ {
        "x" : 411,
        "y" : 335
      } ]
    } ]
  }, {
    "id" : 12555,
    "reactomeId" : 10980656,
    "displayName" : "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 797,
      "y" : 631
    },
    "minX" : 773,
    "maxX" : 834,
    "minY" : 621,
    "maxY" : 637,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 773,
        "y" : 621
      },
      "to" : {
        "x" : 797,
        "y" : 631
      }
    }, {
      "from" : {
        "x" : 797,
        "y" : 631
      },
      "to" : {
        "x" : 834,
        "y" : 631
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 797,
        "y" : 631
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 797,
        "y" : 631
      }
    },
    "inputs" : [ {
      "id" : 12556,
      "points" : [ {
        "x" : 750,
        "y" : 608
      } ]
    }, {
      "id" : 12548,
      "points" : [ {
        "x" : 198,
        "y" : 562
      }, {
        "x" : 745,
        "y" : 565
      } ]
    }, {
      "id" : 12554,
      "points" : [ {
        "x" : 756,
        "y" : 623
      } ]
    } ],
    "outputs" : [ {
      "id" : 12557,
      "points" : [ {
        "x" : 937,
        "y" : 631
      } ]
    }, {
      "id" : 12558,
      "points" : [ {
        "x" : 862,
        "y" : 609
      } ]
    } ]
  }, {
    "id" : 12543,
    "reactomeId" : 10980607,
    "displayName" : "UBA1 conjugates ubiquitin to cytosolic E2 enzymes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 540,
      "y" : 405
    },
    "minX" : 534,
    "maxX" : 546,
    "minY" : 387,
    "maxY" : 425,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 539,
        "y" : 387
      },
      "to" : {
        "x" : 540,
        "y" : 405
      }
    }, {
      "from" : {
        "x" : 540,
        "y" : 405
      },
      "to" : {
        "x" : 540,
        "y" : 425
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 534,
        "y" : 399
      },
      "b" : {
        "x" : 546,
        "y" : 411
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 540,
        "y" : 405
      }
    },
    "inputs" : [ {
      "id" : 12541,
      "points" : [ {
        "x" : 594,
        "y" : 349
      }, {
        "x" : 538,
        "y" : 360
      } ]
    }, {
      "id" : 12544,
      "points" : [ {
        "x" : 581,
        "y" : 383
      } ]
    } ],
    "outputs" : [ {
      "id" : 12534,
      "points" : [ {
        "x" : 79,
        "y" : 349
      }, {
        "x" : 28,
        "y" : 358
      }, {
        "x" : 32,
        "y" : 401
      } ]
    }, {
      "id" : 12545,
      "points" : [ {
        "x" : 594,
        "y" : 432
      } ]
    } ]
  }, {
    "id" : 12559,
    "reactomeId" : 10980654,
    "displayName" : "UBA1 conjugates ubiquitin to nuclear E2 enzymes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1069,
      "y" : 687
    },
    "minX" : 1063,
    "maxX" : 1075,
    "minY" : 665,
    "maxY" : 715,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1069,
        "y" : 665
      },
      "to" : {
        "x" : 1069,
        "y" : 687
      }
    }, {
      "from" : {
        "x" : 1069,
        "y" : 687
      },
      "to" : {
        "x" : 1071,
        "y" : 715
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1063,
        "y" : 681
      },
      "b" : {
        "x" : 1075,
        "y" : 693
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1069,
        "y" : 687
      }
    },
    "inputs" : [ {
      "id" : 12560,
      "points" : [ {
        "x" : 1196,
        "y" : 653
      } ]
    }, {
      "id" : 12557,
      "points" : [ {
        "x" : 1064,
        "y" : 646
      } ]
    } ],
    "outputs" : [ {
      "id" : 12561,
      "points" : [ {
        "x" : 1148,
        "y" : 726
      } ]
    }, {
      "id" : 12551,
      "points" : [ {
        "x" : 451,
        "y" : 646
      }, {
        "x" : 493,
        "y" : 715
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 12562,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 811,
      "y" : 430
    },
    "minX" : 0,
    "maxX" : 1623,
    "minY" : 0,
    "maxY" : 860,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1623,
      "height" : 860
    },
    "textPosition" : {
      "x" : 25,
      "y" : 806
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1603,
      "height" : 840
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 12563, 12513, 12514, 12515, 12516, 12517, 12518, 12519, 12520, 12521, 12522, 12523, 12524, 12525, 12526, 12527, 12528, 12529, 12530, 12532, 12534, 12535, 12536, 12537, 12538, 12539, 12531, 12571, 12572, 12573, 12574, 12575, 12576, 12577, 12578, 12579, 12580, 12581, 12582, 12583, 12584, 12540, 12541, 12533, 12542, 12543, 12544, 12545, 12585 ]
  }, {
    "id" : 12563,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 770,
      "y" : 664
    },
    "minX" : 21,
    "maxX" : 1519,
    "minY" : 530,
    "maxY" : 799,
    "prop" : {
      "x" : 21,
      "y" : 530,
      "width" : 1498,
      "height" : 269
    },
    "textPosition" : {
      "x" : 73,
      "y" : 729
    },
    "insets" : {
      "x" : 31,
      "y" : 540,
      "width" : 1478,
      "height" : 249
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 12546, 12550, 12551, 12549, 12552, 12553, 12554, 12555, 12557, 12558, 12559, 12560, 12561, 12548, 12556, 12547 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 12577,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 755,
      "y" : 180
    },
    "minX" : 749,
    "maxX" : 761,
    "minY" : 149,
    "maxY" : 211,
    "segments" : [ {
      "from" : {
        "x" : 753,
        "y" : 149
      },
      "to" : {
        "x" : 758,
        "y" : 211
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 749,
        "y" : 174
      },
      "b" : {
        "x" : 761,
        "y" : 186
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 755,
        "y" : 180
      }
    },
    "inputs" : [ {
      "id" : 12525
    } ],
    "outputs" : [ {
      "id" : 12531
    } ]
  }, {
    "id" : 12578,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 650,
      "y" : 180
    },
    "minX" : 580,
    "maxX" : 720,
    "minY" : 150,
    "maxY" : 211,
    "segments" : [ {
      "from" : {
        "x" : 580,
        "y" : 150
      },
      "to" : {
        "x" : 720,
        "y" : 211
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 644,
        "y" : 174
      },
      "b" : {
        "x" : 656,
        "y" : 186
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 650,
        "y" : 180
      }
    },
    "inputs" : [ {
      "id" : 12527
    } ],
    "outputs" : [ {
      "id" : 12531
    } ]
  }, {
    "id" : 12579,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 800,
      "y" : 180
    },
    "minX" : 774,
    "maxX" : 827,
    "minY" : 149,
    "maxY" : 211,
    "segments" : [ {
      "from" : {
        "x" : 827,
        "y" : 149
      },
      "to" : {
        "x" : 774,
        "y" : 211
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 794,
        "y" : 174
      },
      "b" : {
        "x" : 806,
        "y" : 186
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 800,
        "y" : 180
      }
    },
    "inputs" : [ {
      "id" : 12524
    } ],
    "outputs" : [ {
      "id" : 12531
    } ]
  }, {
    "id" : 12581,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 443,
      "y" : 195
    },
    "minX" : 187,
    "maxX" : 699,
    "minY" : 163,
    "maxY" : 228,
    "segments" : [ {
      "from" : {
        "x" : 187,
        "y" : 163
      },
      "to" : {
        "x" : 699,
        "y" : 228
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 437,
        "y" : 189
      },
      "b" : {
        "x" : 449,
        "y" : 201
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 443,
        "y" : 195
      }
    },
    "inputs" : [ {
      "id" : 12516
    } ],
    "outputs" : [ {
      "id" : 12531
    } ]
  }, {
    "id" : 12582,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 472,
      "y" : 180
    },
    "minX" : 245,
    "maxX" : 699,
    "minY" : 137,
    "maxY" : 224,
    "segments" : [ {
      "from" : {
        "x" : 245,
        "y" : 137
      },
      "to" : {
        "x" : 699,
        "y" : 224
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 466,
        "y" : 174
      },
      "b" : {
        "x" : 478,
        "y" : 186
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 472,
        "y" : 180
      }
    },
    "inputs" : [ {
      "id" : 12517
    } ],
    "outputs" : [ {
      "id" : 12531
    } ]
  }, {
    "id" : 12583,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 582,
      "y" : 179
    },
    "minX" : 466,
    "maxX" : 699,
    "minY" : 141,
    "maxY" : 217,
    "segments" : [ {
      "from" : {
        "x" : 466,
        "y" : 141
      },
      "to" : {
        "x" : 699,
        "y" : 217
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 576,
        "y" : 173
      },
      "b" : {
        "x" : 588,
        "y" : 185
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 582,
        "y" : 179
      }
    },
    "inputs" : [ {
      "id" : 12528
    } ],
    "outputs" : [ {
      "id" : 12531
    } ]
  }, {
    "id" : 12584,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 706,
      "y" : 180
    },
    "minX" : 672,
    "maxX" : 740,
    "minY" : 150,
    "maxY" : 211,
    "segments" : [ {
      "from" : {
        "x" : 672,
        "y" : 150
      },
      "to" : {
        "x" : 740,
        "y" : 211
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 700,
        "y" : 174
      },
      "b" : {
        "x" : 712,
        "y" : 186
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 706,
        "y" : 180
      }
    },
    "inputs" : [ {
      "id" : 12526
    } ],
    "outputs" : [ {
      "id" : 12531
    } ]
  }, {
    "id" : 12571,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 904,
      "y" : 168
    },
    "minX" : 801,
    "maxX" : 1008,
    "minY" : 125,
    "maxY" : 211,
    "segments" : [ {
      "from" : {
        "x" : 1008,
        "y" : 125
      },
      "to" : {
        "x" : 801,
        "y" : 211
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 898,
        "y" : 162
      },
      "b" : {
        "x" : 910,
        "y" : 174
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 904,
        "y" : 168
      }
    },
    "inputs" : [ {
      "id" : 12522
    } ],
    "outputs" : [ {
      "id" : 12531
    } ]
  }, {
    "id" : 12572,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 852,
      "y" : 176
    },
    "minX" : 790,
    "maxX" : 914,
    "minY" : 141,
    "maxY" : 211,
    "segments" : [ {
      "from" : {
        "x" : 914,
        "y" : 141
      },
      "to" : {
        "x" : 790,
        "y" : 211
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 846,
        "y" : 170
      },
      "b" : {
        "x" : 858,
        "y" : 182
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 852,
        "y" : 176
      }
    },
    "inputs" : [ {
      "id" : 12523
    } ],
    "outputs" : [ {
      "id" : 12531
    } ]
  }, {
    "id" : 12573,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 410,
      "y" : 211
    },
    "minX" : 122,
    "maxX" : 699,
    "minY" : 192,
    "maxY" : 231,
    "segments" : [ {
      "from" : {
        "x" : 122,
        "y" : 192
      },
      "to" : {
        "x" : 699,
        "y" : 231
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 404,
        "y" : 205
      },
      "b" : {
        "x" : 416,
        "y" : 217
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 410,
        "y" : 211
      }
    },
    "inputs" : [ {
      "id" : 12515
    } ],
    "outputs" : [ {
      "id" : 12531
    } ]
  }, {
    "id" : 12574,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 529,
      "y" : 173
    },
    "minX" : 360,
    "maxX" : 699,
    "minY" : 127,
    "maxY" : 220,
    "segments" : [ {
      "from" : {
        "x" : 360,
        "y" : 127
      },
      "to" : {
        "x" : 699,
        "y" : 220
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 523,
        "y" : 167
      },
      "b" : {
        "x" : 535,
        "y" : 179
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 529,
        "y" : 173
      }
    },
    "inputs" : [ {
      "id" : 12529
    } ],
    "outputs" : [ {
      "id" : 12531
    } ]
  }, {
    "id" : 12575,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 965,
      "y" : 158
    },
    "minX" : 811,
    "maxX" : 1119,
    "minY" : 105,
    "maxY" : 211,
    "segments" : [ {
      "from" : {
        "x" : 1119,
        "y" : 105
      },
      "to" : {
        "x" : 811,
        "y" : 211
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 959,
        "y" : 152
      },
      "b" : {
        "x" : 971,
        "y" : 164
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 965,
        "y" : 158
      }
    },
    "inputs" : [ {
      "id" : 12521
    } ],
    "outputs" : [ {
      "id" : 12531
    } ]
  } ],
  "shadows" : [ {
    "id" : 12585,
    "reactomeId" : 10995731,
    "displayName" : "Synthesis of active ubiquitin: roles of E1 and E2 enzymes",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 709,
      "y" : 386
    },
    "minX" : 7,
    "maxX" : 1412,
    "minY" : 7,
    "maxY" : 765,
    "prop" : {
      "x" : 7,
      "y" : 7,
      "width" : 1405,
      "height" : 758
    },
    "points" : [ {
      "x" : 7,
      "y" : 7
    }, {
      "x" : 1412,
      "y" : 7
    }, {
      "x" : 1412,
      "y" : 765
    }, {
      "x" : 7,
      "y" : 765
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 1623,
  "minY" : 0,
  "maxY" : 860,
  "disease" : false
}