{
  "dbId" : 10995673,
  "stableId" : "R-CEL-6804758",
  "displayName" : "Regulation of TP53 Activity through Acetylation",
  "nodes" : [ {
    "id" : 54816,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 523,
      "y" : 809
    },
    "minX" : 501,
    "maxX" : 547,
    "minY" : 777,
    "maxY" : 823,
    "prop" : {
      "x" : 501,
      "y" : 796,
      "width" : 45,
      "height" : 27
    },
    "textPosition" : {
      "x" : 507,
      "y" : 799
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 541,
          "y" : 801
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 541,
          "y" : 801
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54812,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 516,
          "y" : 793
        },
        "to" : {
          "x" : 507,
          "y" : 777
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 509,
          "y" : 789
        },
        "b" : {
          "x" : 516,
          "y" : 793
        },
        "c" : {
          "x" : 516,
          "y" : 785
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 516,
          "y" : 785
        }
      }
    } ]
  }, {
    "id" : 54817,
    "reactomeId" : 10939468,
    "displayName" : "phospho-p-S207,T211-MAP2K6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 454,
      "y" : 847
    },
    "minX" : 395,
    "maxX" : 519,
    "minY" : 789,
    "maxY" : 867,
    "prop" : {
      "x" : 395,
      "y" : 828,
      "width" : 118,
      "height" : 39
    },
    "textPosition" : {
      "x" : 396,
      "y" : 830
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 513,
          "y" : 828
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 513,
          "y" : 828
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54812,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 454,
          "y" : 825
        },
        "to" : {
          "x" : 455,
          "y" : 797
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 455,
          "y" : 793
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 455,
          "y" : 793
        }
      }
    } ]
  }, {
    "id" : 54819,
    "reactomeId" : 10943643,
    "displayName" : "pinn-1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 715,
      "y" : 816
    },
    "minX" : 695,
    "maxX" : 750,
    "minY" : 768,
    "maxY" : 827,
    "prop" : {
      "x" : 695,
      "y" : 806,
      "width" : 40,
      "height" : 21
    },
    "textPosition" : {
      "x" : 695,
      "y" : 799
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 735,
          "y" : 806
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 735,
          "y" : 806
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54818,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 722,
          "y" : 803
        },
        "to" : {
          "x" : 750,
          "y" : 768
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54820,
    "reactomeId" : 10983083,
    "displayName" : "p-S326-PIP4K2B dimers:PIN1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 920,
      "y" : 779
    },
    "minX" : 861,
    "maxX" : 985,
    "minY" : 756,
    "maxY" : 796,
    "prop" : {
      "x" : 861,
      "y" : 762,
      "width" : 118,
      "height" : 34
    },
    "textPosition" : {
      "x" : 865,
      "y" : 761
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 979,
          "y" : 762
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 979,
          "y" : 762
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54818,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54795,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 505,
      "y" : 301
    },
    "minX" : 482,
    "maxX" : 562,
    "minY" : 285,
    "maxY" : 316,
    "prop" : {
      "x" : 482,
      "y" : 286,
      "width" : 47,
      "height" : 30
    },
    "textPosition" : {
      "x" : 490,
      "y" : 290
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 524,
          "y" : 291
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 524,
          "y" : 291
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54794,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 532,
          "y" : 302
        },
        "to" : {
          "x" : 562,
          "y" : 304
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54796,
    "reactomeId" : 10977796,
    "displayName" : "KAT6A:ING5:MEAF6:BRPF1,(2,3)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 575,
      "y" : 347
    },
    "minX" : 511,
    "maxX" : 646,
    "minY" : 304,
    "maxY" : 365,
    "prop" : {
      "x" : 511,
      "y" : 329,
      "width" : 129,
      "height" : 36
    },
    "textPosition" : {
      "x" : 511,
      "y" : 330
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 640,
          "y" : 329
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 640,
          "y" : 329
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54794,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 569,
          "y" : 326
        },
        "to" : {
          "x" : 562,
          "y" : 304
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54797,
    "reactomeId" : 10977801,
    "displayName" : "p-T369-KAT6A:ING5:MEAF6:BRPF1,(2,3)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 592,
      "y" : 127
    },
    "minX" : 517,
    "maxX" : 673,
    "minY" : 102,
    "maxY" : 219,
    "prop" : {
      "x" : 517,
      "y" : 108,
      "width" : 150,
      "height" : 39
    },
    "textPosition" : {
      "x" : 527,
      "y" : 112
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 667,
          "y" : 108
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 667,
          "y" : 108
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54794,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 584,
          "y" : 150
        },
        "to" : {
          "x" : 556,
          "y" : 219
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 585,
          "y" : 158
        },
        "b" : {
          "x" : 584,
          "y" : 150
        },
        "c" : {
          "x" : 578,
          "y" : 155
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 578,
          "y" : 155
        }
      }
    } ]
  }, {
    "id" : 54798,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 493,
      "y" : 189
    },
    "minX" : 473,
    "maxX" : 556,
    "minY" : 173,
    "maxY" : 219,
    "prop" : {
      "x" : 473,
      "y" : 174,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 477,
      "y" : 178
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 509,
          "y" : 179
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 509,
          "y" : 179
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54794,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 517,
          "y" : 198
        },
        "to" : {
          "x" : 556,
          "y" : 219
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 525,
          "y" : 198
        },
        "b" : {
          "x" : 517,
          "y" : 198
        },
        "c" : {
          "x" : 521,
          "y" : 205
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 521,
          "y" : 205
        }
      }
    } ]
  }, {
    "id" : 54799,
    "reactomeId" : 10927787,
    "displayName" : "p-T,p-S-AKT",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 689,
      "y" : 241
    },
    "minX" : 568,
    "maxX" : 725,
    "minY" : 230,
    "maxY" : 259,
    "prop" : {
      "x" : 654,
      "y" : 230,
      "width" : 71,
      "height" : 22
    },
    "textPosition" : {
      "x" : 662,
      "y" : 224
    },
    "connectors" : [ {
      "edgeId" : 54794,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 648,
          "y" : 245
        },
        "to" : {
          "x" : 576,
          "y" : 255
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 572,
          "y" : 255
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 572,
          "y" : 255
        }
      }
    } ]
  }, {
    "id" : 54801,
    "reactomeId" : 10978671,
    "displayName" : "pipp-4p",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 141,
      "y" : 384
    },
    "minX" : 108,
    "maxX" : 181,
    "minY" : 367,
    "maxY" : 395,
    "prop" : {
      "x" : 108,
      "y" : 373,
      "width" : 67,
      "height" : 22
    },
    "textPosition" : {
      "x" : 114,
      "y" : 373
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 175,
          "y" : 373
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 175,
          "y" : 373
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54800,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54802,
    "reactomeId" : 10978673,
    "displayName" : "pipp-4p",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 485,
      "y" : 399
    },
    "minX" : 426,
    "maxX" : 525,
    "minY" : 380,
    "maxY" : 591,
    "prop" : {
      "x" : 452,
      "y" : 386,
      "width" : 67,
      "height" : 27
    },
    "textPosition" : {
      "x" : 458,
      "y" : 389
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 519,
          "y" : 386
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 519,
          "y" : 386
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54800,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 54803,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 488,
          "y" : 416
        },
        "to" : {
          "x" : 513,
          "y" : 501
        }
      }, {
        "from" : {
          "x" : 513,
          "y" : 501
        },
        "to" : {
          "x" : 433,
          "y" : 584
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 430,
          "y" : 587
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 430,
          "y" : 587
        }
      }
    } ]
  }, {
    "id" : 54804,
    "reactomeId" : 113518,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 442,
      "y" : 513
    },
    "minX" : 408,
    "maxX" : 465,
    "minY" : 499,
    "maxY" : 526,
    "prop" : {
      "x" : 420,
      "y" : 500,
      "width" : 44,
      "height" : 26
    },
    "textPosition" : {
      "x" : 425,
      "y" : 502
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 459,
          "y" : 505
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 459,
          "y" : 505
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54803,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 417,
          "y" : 520
        },
        "to" : {
          "x" : 408,
          "y" : 524
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 54805,
    "reactomeId" : 6810412,
    "displayName" : "PI(4,5)P2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 356,
      "y" : 466
    },
    "minX" : 322,
    "maxX" : 408,
    "minY" : 450,
    "maxY" : 524,
    "prop" : {
      "x" : 322,
      "y" : 451,
      "width" : 69,
      "height" : 30
    },
    "textPosition" : {
      "x" : 324,
      "y" : 455
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 386,
          "y" : 456
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 386,
          "y" : 456
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54803,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 369,
          "y" : 484
        },
        "to" : {
          "x" : 408,
          "y" : 524
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 54808,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 376,
          "y" : 484
        },
        "to" : {
          "x" : 401,
          "y" : 499
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 384,
          "y" : 484
        },
        "b" : {
          "x" : 376,
          "y" : 484
        },
        "c" : {
          "x" : 380,
          "y" : 491
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 380,
          "y" : 491
        }
      }
    } ]
  }, {
    "id" : 54806,
    "reactomeId" : 113550,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 375,
      "y" : 661
    },
    "minX" : 359,
    "maxX" : 426,
    "minY" : 649,
    "maxY" : 672,
    "prop" : {
      "x" : 359,
      "y" : 650,
      "width" : 33,
      "height" : 22
    },
    "textPosition" : {
      "x" : 366,
      "y" : 650
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 387,
          "y" : 655
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 387,
          "y" : 655
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54803,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 395,
          "y" : 661
        },
        "to" : {
          "x" : 426,
          "y" : 663
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 402,
          "y" : 657
        },
        "b" : {
          "x" : 395,
          "y" : 661
        },
        "c" : {
          "x" : 402,
          "y" : 665
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 402,
          "y" : 665
        }
      }
    } ]
  }, {
    "id" : 54807,
    "reactomeId" : 6810408,
    "displayName" : "PI5P",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 555,
      "y" : 675
    },
    "minX" : 422,
    "maxX" : 577,
    "minY" : 659,
    "maxY" : 690,
    "prop" : {
      "x" : 535,
      "y" : 660,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 538,
      "y" : 664
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 571,
          "y" : 665
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 571,
          "y" : 665
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54803,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 532,
          "y" : 673
        },
        "to" : {
          "x" : 426,
          "y" : 663
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 525,
          "y" : 676
        },
        "b" : {
          "x" : 532,
          "y" : 673
        },
        "c" : {
          "x" : 525,
          "y" : 668
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 525,
          "y" : 668
        }
      }
    }, {
      "edgeId" : 54808,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 532,
          "y" : 674
        },
        "to" : {
          "x" : 422,
          "y" : 673
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54809,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 387,
      "y" : 699
    },
    "minX" : 367,
    "maxX" : 422,
    "minY" : 673,
    "maxY" : 709,
    "prop" : {
      "x" : 367,
      "y" : 690,
      "width" : 41,
      "height" : 19
    },
    "textPosition" : {
      "x" : 372,
      "y" : 689
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 403,
          "y" : 695
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 403,
          "y" : 695
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54808,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 399,
          "y" : 687
        },
        "to" : {
          "x" : 422,
          "y" : 673
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54810,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 474,
      "y" : 480
    },
    "minX" : 401,
    "maxX" : 498,
    "minY" : 468,
    "maxY" : 499,
    "prop" : {
      "x" : 451,
      "y" : 469,
      "width" : 46,
      "height" : 22
    },
    "textPosition" : {
      "x" : 457,
      "y" : 469
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 492,
          "y" : 474
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 492,
          "y" : 474
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54808,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 448,
          "y" : 485
        },
        "to" : {
          "x" : 401,
          "y" : 499
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 443,
          "y" : 491
        },
        "b" : {
          "x" : 448,
          "y" : 485
        },
        "c" : {
          "x" : 440,
          "y" : 483
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 440,
          "y" : 483
        }
      }
    } ]
  }, {
    "id" : 54811,
    "reactomeId" : 10978973,
    "displayName" : "PIP4K2 dimers",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 333,
      "y" : 622
    },
    "minX" : 303,
    "maxX" : 400,
    "minY" : 602,
    "maxY" : 642,
    "prop" : {
      "x" : 303,
      "y" : 602,
      "width" : 61,
      "height" : 40
    },
    "textPosition" : {
      "x" : 306,
      "y" : 604
    },
    "connectors" : [ {
      "edgeId" : 54808,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 370,
          "y" : 620
        },
        "to" : {
          "x" : 392,
          "y" : 619
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 396,
          "y" : 619
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 396,
          "y" : 619
        }
      }
    } ]
  }, {
    "id" : 54813,
    "reactomeId" : 10983067,
    "displayName" : "PIP4K2B dimers",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 313,
      "y" : 748
    },
    "minX" : 263,
    "maxX" : 414,
    "minY" : 737,
    "maxY" : 774,
    "prop" : {
      "x" : 263,
      "y" : 737,
      "width" : 100,
      "height" : 22
    },
    "textPosition" : {
      "x" : 282,
      "y" : 731
    },
    "connectors" : [ {
      "edgeId" : 54812,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 355,
          "y" : 765
        },
        "to" : {
          "x" : 414,
          "y" : 774
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54814,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 399,
      "y" : 799
    },
    "minX" : 378,
    "maxX" : 421,
    "minY" : 774,
    "maxY" : 813,
    "prop" : {
      "x" : 378,
      "y" : 786,
      "width" : 42,
      "height" : 27
    },
    "textPosition" : {
      "x" : 383,
      "y" : 789
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 415,
          "y" : 791
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 415,
          "y" : 791
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54812,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 407,
          "y" : 783
        },
        "to" : {
          "x" : 414,
          "y" : 774
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54815,
    "reactomeId" : 10983078,
    "displayName" : "p-S326-PIP4K2B dimers",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 631,
      "y" : 767
    },
    "minX" : 507,
    "maxX" : 750,
    "minY" : 748,
    "maxY" : 786,
    "prop" : {
      "x" : 573,
      "y" : 748,
      "width" : 116,
      "height" : 38
    },
    "textPosition" : {
      "x" : 576,
      "y" : 749
    },
    "connectors" : [ {
      "edgeId" : 54818,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 695,
          "y" : 767
        },
        "to" : {
          "x" : 750,
          "y" : 768
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 54812,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 567,
          "y" : 771
        },
        "to" : {
          "x" : 507,
          "y" : 777
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 561,
          "y" : 776
        },
        "b" : {
          "x" : 567,
          "y" : 771
        },
        "c" : {
          "x" : 560,
          "y" : 768
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 560,
          "y" : 768
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 54800,
    "reactomeId" : 10978675,
    "displayName" : "TMEM55B translocates to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 259,
      "y" : 380
    },
    "minX" : 178,
    "maxX" : 449,
    "minY" : 374,
    "maxY" : 396,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 178,
        "y" : 382
      },
      "to" : {
        "x" : 259,
        "y" : 380
      }
    }, {
      "from" : {
        "x" : 259,
        "y" : 380
      },
      "to" : {
        "x" : 449,
        "y" : 396
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 442,
        "y" : 399
      },
      "b" : {
        "x" : 449,
        "y" : 396
      },
      "c" : {
        "x" : 442,
        "y" : 391
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 442,
        "y" : 391
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 253,
        "y" : 374
      },
      "b" : {
        "x" : 265,
        "y" : 386
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 259,
        "y" : 380
      }
    },
    "inputs" : [ {
      "id" : 54801
    } ],
    "outputs" : [ {
      "id" : 54802
    } ]
  }, {
    "id" : 54818,
    "reactomeId" : 10983085,
    "displayName" : "PIN1 binds phosphorylated PIP4K2B",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 786,
      "y" : 774
    },
    "minX" : 750,
    "maxX" : 858,
    "minY" : 768,
    "maxY" : 780,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 750,
        "y" : 768
      },
      "to" : {
        "x" : 786,
        "y" : 774
      }
    }, {
      "from" : {
        "x" : 786,
        "y" : 774
      },
      "to" : {
        "x" : 858,
        "y" : 776
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 851,
        "y" : 780
      },
      "b" : {
        "x" : 858,
        "y" : 776
      },
      "c" : {
        "x" : 851,
        "y" : 772
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 851,
        "y" : 772
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 786,
        "y" : 774
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 786,
        "y" : 774
      }
    },
    "inputs" : [ {
      "id" : 54815,
      "points" : [ {
        "x" : 695,
        "y" : 767
      } ]
    }, {
      "id" : 54819,
      "points" : [ {
        "x" : 722,
        "y" : 803
      } ]
    } ],
    "outputs" : [ {
      "id" : 54820
    } ]
  }, {
    "id" : 54803,
    "reactomeId" : 10978678,
    "displayName" : "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 422,
      "y" : 596
    },
    "minX" : 408,
    "maxX" : 428,
    "minY" : 524,
    "maxY" : 663,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 408,
        "y" : 524
      },
      "to" : {
        "x" : 422,
        "y" : 596
      }
    }, {
      "from" : {
        "x" : 422,
        "y" : 596
      },
      "to" : {
        "x" : 426,
        "y" : 663
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 416,
        "y" : 590
      },
      "b" : {
        "x" : 428,
        "y" : 602
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 422,
        "y" : 596
      }
    },
    "inputs" : [ {
      "id" : 54804,
      "points" : [ {
        "x" : 417,
        "y" : 520
      } ]
    }, {
      "id" : 54805,
      "points" : [ {
        "x" : 369,
        "y" : 484
      } ]
    } ],
    "outputs" : [ {
      "id" : 54806,
      "points" : [ {
        "x" : 395,
        "y" : 661
      } ]
    }, {
      "id" : 54807,
      "points" : [ {
        "x" : 532,
        "y" : 673
      } ]
    } ],
    "catalysts" : [ {
      "id" : 54802,
      "points" : [ {
        "x" : 488,
        "y" : 416
      }, {
        "x" : 513,
        "y" : 501
      } ]
    } ]
  }, {
    "id" : 54808,
    "reactomeId" : 10978976,
    "displayName" : "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 408,
      "y" : 619
    },
    "minX" : 401,
    "maxX" : 422,
    "minY" : 499,
    "maxY" : 673,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 422,
        "y" : 673
      },
      "to" : {
        "x" : 408,
        "y" : 619
      }
    }, {
      "from" : {
        "x" : 408,
        "y" : 619
      },
      "to" : {
        "x" : 401,
        "y" : 499
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 402,
        "y" : 613
      },
      "b" : {
        "x" : 414,
        "y" : 625
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 408,
        "y" : 619
      }
    },
    "inputs" : [ {
      "id" : 54809,
      "points" : [ {
        "x" : 399,
        "y" : 687
      } ]
    }, {
      "id" : 54807,
      "points" : [ {
        "x" : 532,
        "y" : 674
      } ]
    } ],
    "outputs" : [ {
      "id" : 54810,
      "points" : [ {
        "x" : 448,
        "y" : 485
      } ]
    }, {
      "id" : 54805,
      "points" : [ {
        "x" : 376,
        "y" : 484
      } ]
    } ],
    "catalysts" : [ {
      "id" : 54811,
      "points" : [ {
        "x" : 370,
        "y" : 620
      } ]
    } ]
  }, {
    "id" : 54794,
    "reactomeId" : 10977803,
    "displayName" : "AKT phosphorylates KAT6A",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 560,
      "y" : 257
    },
    "minX" : 554,
    "maxX" : 566,
    "minY" : 219,
    "maxY" : 304,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 562,
        "y" : 304
      },
      "to" : {
        "x" : 560,
        "y" : 257
      }
    }, {
      "from" : {
        "x" : 560,
        "y" : 257
      },
      "to" : {
        "x" : 556,
        "y" : 219
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 554,
        "y" : 251
      },
      "b" : {
        "x" : 566,
        "y" : 263
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 560,
        "y" : 257
      }
    },
    "inputs" : [ {
      "id" : 54795,
      "points" : [ {
        "x" : 532,
        "y" : 302
      } ]
    }, {
      "id" : 54796,
      "points" : [ {
        "x" : 569,
        "y" : 326
      } ]
    } ],
    "outputs" : [ {
      "id" : 54797,
      "points" : [ {
        "x" : 584,
        "y" : 150
      } ]
    }, {
      "id" : 54798,
      "points" : [ {
        "x" : 517,
        "y" : 198
      } ]
    } ],
    "catalysts" : [ {
      "id" : 54799,
      "points" : [ {
        "x" : 648,
        "y" : 245
      } ]
    } ]
  }, {
    "id" : 54812,
    "reactomeId" : 10983081,
    "displayName" : "MAP2K6 phosphorylates PIP4K2B",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 456,
      "y" : 781
    },
    "minX" : 414,
    "maxX" : 507,
    "minY" : 774,
    "maxY" : 787,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 414,
        "y" : 774
      },
      "to" : {
        "x" : 456,
        "y" : 781
      }
    }, {
      "from" : {
        "x" : 456,
        "y" : 781
      },
      "to" : {
        "x" : 507,
        "y" : 777
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 450,
        "y" : 775
      },
      "b" : {
        "x" : 462,
        "y" : 787
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 456,
        "y" : 781
      }
    },
    "inputs" : [ {
      "id" : 54813,
      "points" : [ {
        "x" : 355,
        "y" : 765
      } ]
    }, {
      "id" : 54814,
      "points" : [ {
        "x" : 407,
        "y" : 783
      } ]
    } ],
    "outputs" : [ {
      "id" : 54815,
      "points" : [ {
        "x" : 567,
        "y" : 771
      } ]
    }, {
      "id" : 54816,
      "points" : [ {
        "x" : 516,
        "y" : 793
      } ]
    } ],
    "catalysts" : [ {
      "id" : 54817,
      "points" : [ {
        "x" : 454,
        "y" : 825
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 54821,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1034,
      "y" : 493
    },
    "minX" : 0,
    "maxX" : 2068,
    "minY" : 0,
    "maxY" : 986,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 2068,
      "height" : 986
    },
    "textPosition" : {
      "x" : 33,
      "y" : 916
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 2048,
      "height" : 966
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 54822, 54830, 54800 ]
  }, {
    "id" : 54822,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1144,
      "y" : 479
    },
    "minX" : 274,
    "maxX" : 2015,
    "minY" : 56,
    "maxY" : 902,
    "prop" : {
      "x" : 274,
      "y" : 56,
      "width" : 1741,
      "height" : 846
    },
    "textPosition" : {
      "x" : 1272,
      "y" : 637
    },
    "insets" : {
      "x" : 284,
      "y" : 66,
      "width" : 1721,
      "height" : 826
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 54796, 54794, 54795, 54797, 54798, 54799, 54831, 54832, 54833, 54807, 54804, 54805, 54802, 54806, 54808, 54809, 54811, 54803, 54810, 54815, 54812, 54813, 54834, 54814, 54816, 54817, 54818, 54819, 54820 ]
  }, {
    "id" : 54830,
    "reactomeId" : 173031,
    "displayName" : "late endosome lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 133,
      "y" : 328
    },
    "minX" : 44,
    "maxX" : 223,
    "minY" : 270,
    "maxY" : 386,
    "prop" : {
      "x" : 44,
      "y" : 270,
      "width" : 179,
      "height" : 116
    },
    "textPosition" : {
      "x" : 63,
      "y" : 319
    },
    "insets" : {
      "x" : 54,
      "y" : 280,
      "width" : 159,
      "height" : 96
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 54801 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 54834,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 321,
      "y" : 689
    },
    "minX" : 314,
    "maxX" : 329,
    "minY" : 648,
    "maxY" : 731,
    "segments" : [ {
      "from" : {
        "x" : 314,
        "y" : 731
      },
      "to" : {
        "x" : 329,
        "y" : 648
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 315,
        "y" : 683
      },
      "b" : {
        "x" : 327,
        "y" : 695
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 321,
        "y" : 689
      }
    },
    "inputs" : [ {
      "id" : 54813
    } ],
    "outputs" : [ {
      "id" : 54811
    } ]
  } ],
  "shadows" : [ {
    "id" : 54835,
    "reactomeId" : 10995687,
    "displayName" : "PI5P Regulates TP53 Acetylation",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 543,
      "y" : 620
    },
    "minX" : 98,
    "maxX" : 989,
    "minY" : 363,
    "maxY" : 877,
    "prop" : {
      "x" : 98,
      "y" : 363,
      "width" : 891,
      "height" : 514
    },
    "points" : [ {
      "x" : 98,
      "y" : 363
    }, {
      "x" : 989,
      "y" : 363
    }, {
      "x" : 989,
      "y" : 877
    }, {
      "x" : 98,
      "y" : 877
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 2068,
  "minY" : 0,
  "maxY" : 986,
  "disease" : false
}