{
  "dbId" : 10995377,
  "stableId" : "R-CEL-4615885",
  "displayName" : "SUMOylation of DNA replication proteins",
  "nodes" : [ {
    "id" : 28192,
    "reactomeId" : 10962616,
    "displayName" : "pcn-1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 94,
      "y" : 353
    },
    "minX" : 28,
    "maxX" : 167,
    "minY" : 310,
    "maxY" : 376,
    "prop" : {
      "x" : 28,
      "y" : 331,
      "width" : 133,
      "height" : 45
    },
    "textPosition" : {
      "x" : 73,
      "y" : 343
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 161,
          "y" : 331
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 161,
          "y" : 331
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 28188,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 124,
          "y" : 328
        },
        "to" : {
          "x" : 152,
          "y" : 310
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 128,
          "y" : 321
        },
        "b" : {
          "x" : 124,
          "y" : 328
        },
        "c" : {
          "x" : 132,
          "y" : 328
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 132,
          "y" : 328
        }
      }
    } ]
  }, {
    "id" : 28194,
    "reactomeId" : 10962687,
    "displayName" : "top-1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 87,
      "y" : 664
    },
    "minX" : 57,
    "maxX" : 152,
    "minY" : 646,
    "maxY" : 691,
    "prop" : {
      "x" : 57,
      "y" : 652,
      "width" : 60,
      "height" : 24
    },
    "textPosition" : {
      "x" : 66,
      "y" : 653
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 117,
          "y" : 652
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 117,
          "y" : 652
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 28193,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 115,
          "y" : 679
        },
        "to" : {
          "x" : 152,
          "y" : 691
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 28195,
    "reactomeId" : 10959501,
    "displayName" : "SUMO1:C93-UBE2I",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 237,
      "y" : 665
    },
    "minX" : 152,
    "maxX" : 317,
    "minY" : 647,
    "maxY" : 713,
    "prop" : {
      "x" : 163,
      "y" : 653,
      "width" : 148,
      "height" : 24
    },
    "textPosition" : {
      "x" : 177,
      "y" : 656
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 311,
          "y" : 653
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 311,
          "y" : 653
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 28193,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 197,
          "y" : 680
        },
        "to" : {
          "x" : 152,
          "y" : 691
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 28193,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 216,
          "y" : 680
        },
        "to" : {
          "x" : 166,
          "y" : 707
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 163,
          "y" : 709
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 163,
          "y" : 709
        }
      }
    } ]
  }, {
    "id" : 28196,
    "reactomeId" : 10962690,
    "displayName" : "top-1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 94,
      "y" : 769
    },
    "minX" : 43,
    "maxX" : 153,
    "minY" : 737,
    "maxY" : 790,
    "prop" : {
      "x" : 43,
      "y" : 749,
      "width" : 102,
      "height" : 41
    },
    "textPosition" : {
      "x" : 73,
      "y" : 759
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 145,
          "y" : 749
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 145,
          "y" : 749
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 28193,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 131,
          "y" : 746
        },
        "to" : {
          "x" : 153,
          "y" : 737
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 136,
          "y" : 740
        },
        "b" : {
          "x" : 131,
          "y" : 746
        },
        "c" : {
          "x" : 139,
          "y" : 747
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 139,
          "y" : 747
        }
      }
    } ]
  }, {
    "id" : 28197,
    "reactomeId" : 10959493,
    "displayName" : "ubc-9",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 229,
      "y" : 771
    },
    "minX" : 153,
    "maxX" : 271,
    "minY" : 737,
    "maxY" : 784,
    "prop" : {
      "x" : 194,
      "y" : 759,
      "width" : 71,
      "height" : 25
    },
    "textPosition" : {
      "x" : 208,
      "y" : 761
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 265,
          "y" : 759
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 265,
          "y" : 759
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 28193,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 201,
          "y" : 756
        },
        "to" : {
          "x" : 153,
          "y" : 737
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 193,
          "y" : 757
        },
        "b" : {
          "x" : 201,
          "y" : 756
        },
        "c" : {
          "x" : 196,
          "y" : 750
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 196,
          "y" : 750
        }
      }
    } ]
  }, {
    "id" : 28199,
    "reactomeId" : 10962651,
    "displayName" : "TOP2A",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 556,
      "y" : 586
    },
    "minX" : 520,
    "maxX" : 618,
    "minY" : 568,
    "maxY" : 669,
    "prop" : {
      "x" : 520,
      "y" : 574,
      "width" : 72,
      "height" : 25
    },
    "textPosition" : {
      "x" : 532,
      "y" : 576
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 592,
          "y" : 574
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 592,
          "y" : 574
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 28198,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 565,
          "y" : 602
        },
        "to" : {
          "x" : 618,
          "y" : 669
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 28200,
    "reactomeId" : 10959501,
    "displayName" : "SUMO1:C93-UBE2I",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 667,
      "y" : 614
    },
    "minX" : 600,
    "maxX" : 740,
    "minY" : 593,
    "maxY" : 693,
    "prop" : {
      "x" : 600,
      "y" : 599,
      "width" : 134,
      "height" : 30
    },
    "textPosition" : {
      "x" : 607,
      "y" : 608
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 734,
          "y" : 599
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 734,
          "y" : 599
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 28198,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 653,
          "y" : 632
        },
        "to" : {
          "x" : 618,
          "y" : 669
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 28198,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 658,
          "y" : 632
        },
        "to" : {
          "x" : 625,
          "y" : 685
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 623,
          "y" : 689
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 623,
          "y" : 689
        }
      }
    } ]
  }, {
    "id" : 28201,
    "reactomeId" : 10962654,
    "displayName" : "monoSUMO1-K-TOP2A",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 687,
      "y" : 802
    },
    "minX" : 638,
    "maxX" : 741,
    "minY" : 737,
    "maxY" : 828,
    "prop" : {
      "x" : 639,
      "y" : 776,
      "width" : 96,
      "height" : 52
    },
    "textPosition" : {
      "x" : 641,
      "y" : 784
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 735,
          "y" : 776
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 735,
          "y" : 776
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 28198,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 667,
          "y" : 773
        },
        "to" : {
          "x" : 638,
          "y" : 737
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 660,
          "y" : 770
        },
        "b" : {
          "x" : 667,
          "y" : 773
        },
        "c" : {
          "x" : 666,
          "y" : 765
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 666,
          "y" : 765
        }
      }
    } ]
  }, {
    "id" : 28202,
    "reactomeId" : 10959493,
    "displayName" : "ubc-9",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 568,
      "y" : 791
    },
    "minX" : 533,
    "maxX" : 638,
    "minY" : 737,
    "maxY" : 804,
    "prop" : {
      "x" : 533,
      "y" : 779,
      "width" : 71,
      "height" : 25
    },
    "textPosition" : {
      "x" : 547,
      "y" : 781
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 604,
          "y" : 779
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 604,
          "y" : 779
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 28198,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 584,
          "y" : 776
        },
        "to" : {
          "x" : 638,
          "y" : 737
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 587,
          "y" : 769
        },
        "b" : {
          "x" : 584,
          "y" : 776
        },
        "c" : {
          "x" : 592,
          "y" : 775
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 592,
          "y" : 775
        }
      }
    } ]
  }, {
    "id" : 28204,
    "reactomeId" : 10962670,
    "displayName" : "Homologues of TOP2B",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 98,
      "y" : 465
    },
    "minX" : 66,
    "maxX" : 166,
    "minY" : 452,
    "maxY" : 492,
    "prop" : {
      "x" : 66,
      "y" : 452,
      "width" : 64,
      "height" : 26
    },
    "textPosition" : {
      "x" : 66,
      "y" : 441
    },
    "connectors" : [ {
      "edgeId" : 28203,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 133,
          "y" : 477
        },
        "to" : {
          "x" : 166,
          "y" : 492
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 28205,
    "reactomeId" : 10959501,
    "displayName" : "SUMO1:C93-UBE2I",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 243,
      "y" : 465
    },
    "minX" : 166,
    "maxX" : 321,
    "minY" : 447,
    "maxY" : 508,
    "prop" : {
      "x" : 171,
      "y" : 453,
      "width" : 144,
      "height" : 24
    },
    "textPosition" : {
      "x" : 183,
      "y" : 456
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 315,
          "y" : 453
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 315,
          "y" : 453
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 28203,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 208,
          "y" : 480
        },
        "to" : {
          "x" : 166,
          "y" : 492
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 28203,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 222,
          "y" : 480
        },
        "to" : {
          "x" : 180,
          "y" : 502
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 177,
          "y" : 504
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 177,
          "y" : 504
        }
      }
    } ]
  }, {
    "id" : 28206,
    "reactomeId" : 10962680,
    "displayName" : "Homologues of monoSUMO1-K-TOP2B",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 79,
      "y" : 554
    },
    "minX" : 31,
    "maxX" : 167,
    "minY" : 532,
    "maxY" : 577,
    "prop" : {
      "x" : 31,
      "y" : 532,
      "width" : 96,
      "height" : 45
    },
    "textPosition" : {
      "x" : 33,
      "y" : 523
    },
    "connectors" : [ {
      "edgeId" : 28203,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 130,
          "y" : 542
        },
        "to" : {
          "x" : 167,
          "y" : 533
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 136,
          "y" : 536
        },
        "b" : {
          "x" : 130,
          "y" : 542
        },
        "c" : {
          "x" : 138,
          "y" : 544
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 138,
          "y" : 544
        }
      }
    } ]
  }, {
    "id" : 28207,
    "reactomeId" : 10959493,
    "displayName" : "ubc-9",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 250,
      "y" : 548
    },
    "minX" : 167,
    "maxX" : 289,
    "minY" : 529,
    "maxY" : 562,
    "prop" : {
      "x" : 218,
      "y" : 535,
      "width" : 65,
      "height" : 27
    },
    "textPosition" : {
      "x" : 229,
      "y" : 538
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 283,
          "y" : 535
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 283,
          "y" : 535
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 28203,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 215,
          "y" : 542
        },
        "to" : {
          "x" : 167,
          "y" : 533
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 207,
          "y" : 545
        },
        "b" : {
          "x" : 215,
          "y" : 542
        },
        "c" : {
          "x" : 209,
          "y" : 537
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 209,
          "y" : 537
        }
      }
    } ]
  }, {
    "id" : 28189,
    "reactomeId" : 10914762,
    "displayName" : "pcn-1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 85,
      "y" : 230
    },
    "minX" : 52,
    "maxX" : 152,
    "minY" : 212,
    "maxY" : 267,
    "prop" : {
      "x" : 52,
      "y" : 218,
      "width" : 66,
      "height" : 25
    },
    "textPosition" : {
      "x" : 63,
      "y" : 220
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 118,
          "y" : 218
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 118,
          "y" : 218
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 28188,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 107,
          "y" : 246
        },
        "to" : {
          "x" : 152,
          "y" : 267
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 28190,
    "reactomeId" : 10959501,
    "displayName" : "SUMO1:C93-UBE2I",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 235,
      "y" : 236
    },
    "minX" : 152,
    "maxX" : 315,
    "minY" : 218,
    "maxY" : 288,
    "prop" : {
      "x" : 161,
      "y" : 224,
      "width" : 148,
      "height" : 24
    },
    "textPosition" : {
      "x" : 175,
      "y" : 227
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 309,
          "y" : 224
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 309,
          "y" : 224
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 28188,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 202,
          "y" : 251
        },
        "to" : {
          "x" : 152,
          "y" : 267
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 171,
            "y" : 253
          },
          "b" : {
            "x" : 183,
            "y" : 265
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 177,
            "y" : 259
          }
        }
      }
    }, {
      "edgeId" : 28188,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 216,
          "y" : 251
        },
        "to" : {
          "x" : 166,
          "y" : 282
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 162,
          "y" : 284
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 162,
          "y" : 284
        }
      }
    } ]
  }, {
    "id" : 28191,
    "reactomeId" : 10959493,
    "displayName" : "ubc-9",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 247,
      "y" : 344
    },
    "minX" : 152,
    "maxX" : 289,
    "minY" : 310,
    "maxY" : 357,
    "prop" : {
      "x" : 212,
      "y" : 332,
      "width" : 71,
      "height" : 25
    },
    "textPosition" : {
      "x" : 226,
      "y" : 334
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 283,
          "y" : 332
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 283,
          "y" : 332
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 28188,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 212,
          "y" : 329
        },
        "to" : {
          "x" : 152,
          "y" : 310
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 176,
            "y" : 313
          },
          "b" : {
            "x" : 188,
            "y" : 325
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 182,
            "y" : 319
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 204,
          "y" : 331
        },
        "b" : {
          "x" : 212,
          "y" : 329
        },
        "c" : {
          "x" : 207,
          "y" : 323
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 207,
          "y" : 323
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 28193,
    "reactomeId" : 10962692,
    "displayName" : "SUMOylation of TOP1 with SUMO1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 152,
      "y" : 715
    },
    "minX" : 146,
    "maxX" : 158,
    "minY" : 691,
    "maxY" : 737,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 152,
        "y" : 691
      },
      "to" : {
        "x" : 152,
        "y" : 715
      }
    }, {
      "from" : {
        "x" : 152,
        "y" : 715
      },
      "to" : {
        "x" : 153,
        "y" : 737
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 146,
        "y" : 709
      },
      "b" : {
        "x" : 158,
        "y" : 721
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 152,
        "y" : 715
      }
    },
    "inputs" : [ {
      "id" : 28194,
      "points" : [ {
        "x" : 115,
        "y" : 679
      } ]
    }, {
      "id" : 28195,
      "points" : [ {
        "x" : 197,
        "y" : 680
      } ]
    } ],
    "outputs" : [ {
      "id" : 28196,
      "points" : [ {
        "x" : 131,
        "y" : 746
      } ]
    }, {
      "id" : 28197,
      "points" : [ {
        "x" : 201,
        "y" : 756
      } ]
    } ],
    "catalysts" : [ {
      "id" : 28195,
      "points" : [ {
        "x" : 216,
        "y" : 680
      } ]
    } ]
  }, {
    "id" : 28198,
    "reactomeId" : 10962656,
    "displayName" : "SUMOylation of TOP2A with SUMO1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 617,
      "y" : 699
    },
    "minX" : 611,
    "maxX" : 638,
    "minY" : 669,
    "maxY" : 737,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 618,
        "y" : 669
      },
      "to" : {
        "x" : 617,
        "y" : 699
      }
    }, {
      "from" : {
        "x" : 617,
        "y" : 699
      },
      "to" : {
        "x" : 638,
        "y" : 737
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 611,
        "y" : 693
      },
      "b" : {
        "x" : 623,
        "y" : 705
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 617,
        "y" : 699
      }
    },
    "inputs" : [ {
      "id" : 28199,
      "points" : [ {
        "x" : 565,
        "y" : 602
      } ]
    }, {
      "id" : 28200,
      "points" : [ {
        "x" : 653,
        "y" : 632
      } ]
    } ],
    "outputs" : [ {
      "id" : 28201,
      "points" : [ {
        "x" : 667,
        "y" : 773
      } ]
    }, {
      "id" : 28202,
      "points" : [ {
        "x" : 584,
        "y" : 776
      } ]
    } ],
    "catalysts" : [ {
      "id" : 28200,
      "points" : [ {
        "x" : 658,
        "y" : 632
      } ]
    } ]
  }, {
    "id" : 28203,
    "reactomeId" : 10962682,
    "displayName" : "SUMOylation of TOP2B with SUMO1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 166,
      "y" : 510
    },
    "minX" : 160,
    "maxX" : 172,
    "minY" : 492,
    "maxY" : 533,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 166,
        "y" : 492
      },
      "to" : {
        "x" : 166,
        "y" : 510
      }
    }, {
      "from" : {
        "x" : 166,
        "y" : 510
      },
      "to" : {
        "x" : 167,
        "y" : 533
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 160,
        "y" : 504
      },
      "b" : {
        "x" : 172,
        "y" : 516
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 166,
        "y" : 510
      }
    },
    "inputs" : [ {
      "id" : 28204,
      "points" : [ {
        "x" : 133,
        "y" : 477
      } ]
    }, {
      "id" : 28205,
      "points" : [ {
        "x" : 208,
        "y" : 480
      } ]
    } ],
    "outputs" : [ {
      "id" : 28206,
      "points" : [ {
        "x" : 130,
        "y" : 542
      } ]
    }, {
      "id" : 28207,
      "points" : [ {
        "x" : 215,
        "y" : 542
      } ]
    } ],
    "catalysts" : [ {
      "id" : 28205,
      "points" : [ {
        "x" : 222,
        "y" : 480
      } ]
    } ]
  }, {
    "id" : 28188,
    "reactomeId" : 10962618,
    "displayName" : "SUMOylation of PCNA with SUMO1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 152,
      "y" : 290
    },
    "minX" : 146,
    "maxX" : 158,
    "minY" : 267,
    "maxY" : 310,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 152,
        "y" : 267
      },
      "to" : {
        "x" : 152,
        "y" : 290
      }
    }, {
      "from" : {
        "x" : 152,
        "y" : 290
      },
      "to" : {
        "x" : 152,
        "y" : 310
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 146,
        "y" : 284
      },
      "b" : {
        "x" : 158,
        "y" : 296
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 152,
        "y" : 290
      }
    },
    "inputs" : [ {
      "id" : 28189,
      "points" : [ {
        "x" : 107,
        "y" : 246
      } ]
    }, {
      "id" : 28190,
      "points" : [ {
        "x" : 202,
        "y" : 251
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 28191,
      "points" : [ {
        "x" : 212,
        "y" : 329
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 28192,
      "points" : [ {
        "x" : 124,
        "y" : 328
      } ]
    } ],
    "catalysts" : [ {
      "id" : 28190,
      "points" : [ {
        "x" : 216,
        "y" : 251
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 28208,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 405,
      "y" : 437
    },
    "minX" : 0,
    "maxX" : 810,
    "minY" : 0,
    "maxY" : 875,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 810,
      "height" : 875
    },
    "textPosition" : {
      "x" : 13,
      "y" : 828
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 790,
      "height" : 855
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 28188, 28189, 28191, 28190, 28193, 28194, 28195, 28197, 28198, 28199, 28200, 28202, 28203, 28204, 28205, 28207, 28192, 28196, 28206, 28201 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 810,
  "minY" : 0,
  "maxY" : 875,
  "disease" : false
}