{ "dbId" : 10995017, "stableId" : "R-CEL-1236394", "displayName" : "Signaling by ERBB4", "nodes" : [ { "id" : 57985, "reactomeId" : 10946830, "displayName" : "ERBB4s80", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 604, "y" : 1116 }, "minX" : 569, "maxX" : 639, "minY" : 1106, "maxY" : 1127, "prop" : { "x" : 569, "y" : 1106, "width" : 70, "height" : 21 }, "textPosition" : { "x" : 572, "y" : 1099 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 57984, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 57986, "reactomeId" : 10946832, "displayName" : "ERBB4s80:MyrG-p-Y419-SRC", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 149, "y" : 678 }, "minX" : 114, "maxX" : 439, "minY" : 647, "maxY" : 898, "prop" : { "x" : 114, "y" : 653, "width" : 71, "height" : 50 }, "textPosition" : { "x" : 114, "y" : 654 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 185, "y" : 653 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 185, "y" : 653 } } }, "connectors" : [ { "edgeId" : 57984, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 188, "y" : 692 }, "to" : { "x" : 240, "y" : 716 } }, { "from" : { "x" : 240, "y" : 716 }, "to" : { "x" : 255, "y" : 892 } }, { "from" : { "x" : 255, "y" : 892 }, "to" : { "x" : 439, "y" : 894 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 439, "y" : 898 }, "b" : { "x" : 439, "y" : 890 }, "c" : { "x" : 439, "y" : 894 }, "type" : "STOP", "centre" : { "x" : 439, "y" : 894 } } }, { "edgeId" : 58015, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 57988, "reactomeId" : 10945058, "displayName" : "wwp-1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 329, "y" : 221 }, "minX" : 305, "maxX" : 360, "minY" : 198, "maxY" : 253, "prop" : { "x" : 305, "y" : 204, "width" : 49, "height" : 35 }, "textPosition" : { "x" : 306, "y" : 211 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 354, "y" : 204 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 354, "y" : 204 } } }, "connectors" : [ { "edgeId" : 57987, "type" : "INPUT", "segments" : [ { "from" : { "x" : 337, "y" : 245 }, "to" : { "x" : 344, "y" : 253 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 57989, "reactomeId" : 10946837, "displayName" : "ERBB4/ERBB4m80/ERBB4s80", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 213, "y" : 451 }, "minX" : 153, "maxX" : 344, "minY" : 253, "maxY" : 469, "prop" : { "x" : 153, "y" : 433, "width" : 121, "height" : 36 }, "textPosition" : { "x" : 154, "y" : 433 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 57987, "type" : "INPUT", "segments" : [ { "from" : { "x" : 224, "y" : 427 }, "to" : { "x" : 344, "y" : 253 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 57990, "reactomeId" : 10946839, "displayName" : "ERBB4/m80/s80:WWP1/ITCH", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 454, "y" : 253 }, "minX" : 399, "maxX" : 554, "minY" : 229, "maxY" : 271, "prop" : { "x" : 399, "y" : 235, "width" : 111, "height" : 36 }, "textPosition" : { "x" : 399, "y" : 236 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 510, "y" : 235 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 510, "y" : 235 } } }, "connectors" : [ { "edgeId" : 57987, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 57991, "type" : "INPUT", "segments" : [ { "from" : { "x" : 513, "y" : 251 }, "to" : { "x" : 530, "y" : 251 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 57991, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 513, "y" : 239 }, "to" : { "x" : 550, "y" : 229 } }, { "from" : { "x" : 550, "y" : 229 }, "to" : { "x" : 550, "y" : 235 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 550, "y" : 239 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 550, "y" : 239 } } } ] }, { "id" : 57992, "reactomeId" : 10914504, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 592, "y" : 314 }, "minX" : 530, "maxX" : 627, "minY" : 251, "maxY" : 344, "prop" : { "x" : 558, "y" : 305, "width" : 69, "height" : 19 }, "textPosition" : { "x" : 580, "y" : 304 }, "connectors" : [ { "edgeId" : 57991, "type" : "INPUT", "segments" : [ { "from" : { "x" : 582, "y" : 299 }, "to" : { "x" : 530, "y" : 251 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 58013, "type" : "INPUT", "segments" : [ { "from" : { "x" : 578, "y" : 330 }, "to" : { "x" : 550, "y" : 344 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 57993, "reactomeId" : 10946841, "displayName" : "Ub-ERBB4:WWP1/ITCH", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 622, "y" : 252 }, "minX" : 582, "maxX" : 668, "minY" : 229, "maxY" : 270, "prop" : { "x" : 582, "y" : 235, "width" : 80, "height" : 35 }, "textPosition" : { "x" : 583, "y" : 235 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 662, "y" : 235 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 662, "y" : 235 } } }, "connectors" : [ { "edgeId" : 57991, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 57995, "reactomeId" : 10946851, "displayName" : "WWOX", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 797, "y" : 625 }, "minX" : 769, "maxX" : 831, "minY" : 600, "maxY" : 635, "prop" : { "x" : 769, "y" : 616, "width" : 56, "height" : 19 }, "textPosition" : { "x" : 774, "y" : 615 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 825, "y" : 616 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 825, "y" : 616 } } }, "connectors" : [ { "edgeId" : 57994, "type" : "INPUT", "segments" : [ { "from" : { "x" : 806, "y" : 613 }, "to" : { "x" : 821, "y" : 600 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 57996, "reactomeId" : 10946853, "displayName" : "ERBB4s80:WWOX", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 911, "y" : 600 }, "minX" : 875, "maxX" : 954, "minY" : 577, "maxY" : 618, "prop" : { "x" : 875, "y" : 583, "width" : 73, "height" : 35 }, "textPosition" : { "x" : 876, "y" : 583 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 948, "y" : 583 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 948, "y" : 583 } } }, "connectors" : [ { "edgeId" : 57994, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 57998, "reactomeId" : 10946860, "displayName" : "yap-1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 739, "y" : 710 }, "minX" : 720, "maxX" : 797, "minY" : 693, "maxY" : 721, "prop" : { "x" : 720, "y" : 700, "width" : 38, "height" : 21 }, "textPosition" : { "x" : 722, "y" : 693 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 758, "y" : 700 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 758, "y" : 700 } } }, "connectors" : [ { "edgeId" : 57997, "type" : "INPUT", "segments" : [ { "from" : { "x" : 761, "y" : 704 }, "to" : { "x" : 797, "y" : 693 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 57999, "reactomeId" : 10946862, "displayName" : "ERBB4s80:YAP1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 926, "y" : 767 }, "minX" : 891, "maxX" : 968, "minY" : 744, "maxY" : 784, "prop" : { "x" : 891, "y" : 750, "width" : 71, "height" : 34 }, "textPosition" : { "x" : 891, "y" : 749 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 962, "y" : 750 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 962, "y" : 750 } } }, "connectors" : [ { "edgeId" : 57997, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 58000, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 58001, "reactomeId" : 10946866, "displayName" : "ERBB4s80:YAP1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 940, "y" : 1048 }, "minX" : 904, "maxX" : 982, "minY" : 1025, "maxY" : 1066, "prop" : { "x" : 904, "y" : 1031, "width" : 72, "height" : 35 }, "textPosition" : { "x" : 904, "y" : 1031 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 976, "y" : 1031 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 976, "y" : 1031 } } }, "connectors" : [ { "edgeId" : 58000, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 58003, "reactomeId" : 10946883, "displayName" : "p-Y694-STAT5A homodimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 664, "y" : 766 }, "minX" : 626, "maxX" : 718, "minY" : 736, "maxY" : 790, "prop" : { "x" : 626, "y" : 742, "width" : 76, "height" : 48 }, "textPosition" : { "x" : 627, "y" : 727 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 702, "y" : 742 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 702, "y" : 742 } } }, "connectors" : [ { "edgeId" : 58002, "type" : "INPUT", "segments" : [ { "from" : { "x" : 705, "y" : 761 }, "to" : { "x" : 718, "y" : 759 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 58004, "reactomeId" : 10946885, "displayName" : "ERBB4s80:p-Y694-STAT5A", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 744, "y" : 832 }, "minX" : 708, "maxX" : 786, "minY" : 800, "maxY" : 858, "prop" : { "x" : 708, "y" : 806, "width" : 72, "height" : 52 }, "textPosition" : { "x" : 708, "y" : 809 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 780, "y" : 806 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 780, "y" : 806 } } }, "connectors" : [ { "edgeId" : 58002, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 58005, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 58006, "reactomeId" : 10946897, "displayName" : "ERBB4s80:p-Y694-STAT5A", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 782, "y" : 1005 }, "minX" : 747, "maxX" : 824, "minY" : 975, "maxY" : 1030, "prop" : { "x" : 747, "y" : 981, "width" : 71, "height" : 49 }, "textPosition" : { "x" : 747, "y" : 981 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 818, "y" : 981 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 818, "y" : 981 } } }, "connectors" : [ { "edgeId" : 58005, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 58008, "reactomeId" : 10946911, "displayName" : "ERBB4s80", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 612, "y" : 494 }, "minX" : 577, "maxX" : 648, "minY" : 484, "maxY" : 505, "prop" : { "x" : 577, "y" : 484, "width" : 71, "height" : 21 }, "textPosition" : { "x" : 577, "y" : 484 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 58007, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 58010, "reactomeId" : 10945043, "displayName" : "NEDD4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 370, "y" : 315 }, "minX" : 345, "maxX" : 409, "minY" : 298, "maxY" : 354, "prop" : { "x" : 345, "y" : 304, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 345, "y" : 304 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 396, "y" : 304 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 396, "y" : 304 } } }, "connectors" : [ { "edgeId" : 58009, "type" : "INPUT", "segments" : [ { "from" : { "x" : 381, "y" : 329 }, "to" : { "x" : 409, "y" : 354 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 58011, "reactomeId" : 10946757, "displayName" : "ERBB4jmAcyt1s80 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 398, "y" : 420 }, "minX" : 341, "maxX" : 461, "minY" : 354, "maxY" : 438, "prop" : { "x" : 341, "y" : 403, "width" : 114, "height" : 35 }, "textPosition" : { "x" : 342, "y" : 403 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 455, "y" : 403 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 455, "y" : 403 } } }, "connectors" : [ { "edgeId" : 58009, "type" : "INPUT", "segments" : [ { "from" : { "x" : 400, "y" : 400 }, "to" : { "x" : 409, "y" : 354 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 58012, "reactomeId" : 10952464, "displayName" : "ERBB4jmAcyt1s80:NEDD4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 474, "y" : 310 }, "minX" : 415, "maxX" : 550, "minY" : 286, "maxY" : 369, "prop" : { "x" : 415, "y" : 292, "width" : 119, "height" : 37 }, "textPosition" : { "x" : 415, "y" : 294 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 534, "y" : 292 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 534, "y" : 292 } } }, "connectors" : [ { "edgeId" : 58009, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 58013, "type" : "INPUT", "segments" : [ { "from" : { "x" : 515, "y" : 332 }, "to" : { "x" : 550, "y" : 344 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 58013, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 485, "y" : 332 }, "to" : { "x" : 509, "y" : 366 } }, { "from" : { "x" : 509, "y" : 366 }, "to" : { "x" : 534, "y" : 365 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 538, "y" : 365 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 538, "y" : 365 } } } ] }, { "id" : 58014, "reactomeId" : 10952468, "displayName" : "Ub-ERBB4jmAcyt1s80:NEDD4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 552, "y" : 417 }, "minX" : 475, "maxX" : 636, "minY" : 394, "maxY" : 435, "prop" : { "x" : 475, "y" : 400, "width" : 155, "height" : 35 }, "textPosition" : { "x" : 480, "y" : 400 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 630, "y" : 400 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 630, "y" : 400 } } }, "connectors" : [ { "edgeId" : 58013, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 58016, "reactomeId" : 10931745, "displayName" : "phospho-MyrG-p-Y419-SRC", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 152, "y" : 581 }, "minX" : 118, "maxX" : 215, "minY" : 550, "maxY" : 607, "prop" : { "x" : 118, "y" : 556, "width" : 69, "height" : 51 }, "textPosition" : { "x" : 119, "y" : 557 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 187, "y" : 556 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 187, "y" : 556 } } }, "connectors" : [ { "edgeId" : 58015, "type" : "INPUT", "segments" : [ { "from" : { "x" : 190, "y" : 585 }, "to" : { "x" : 195, "y" : 586 } }, { "from" : { "x" : 195, "y" : 586 }, "to" : { "x" : 215, "y" : 589 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 58018, "reactomeId" : 10946534, "displayName" : "ERBB4", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 146, "y" : 55 }, "minX" : 118, "maxX" : 175, "minY" : 42, "maxY" : 68, "prop" : { "x" : 118, "y" : 42, "width" : 57, "height" : 26 }, "textPosition" : { "x" : 122, "y" : 44 }, "connectors" : [ ] }, { "id" : 58024, "reactomeId" : 10924227, "displayName" : "p21 RAS:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1269, "y" : 535 }, "minX" : 1236, "maxX" : 1309, "minY" : 512, "maxY" : 552, "prop" : { "x" : 1236, "y" : 518, "width" : 67, "height" : 34 }, "textPosition" : { "x" : 1237, "y" : 517 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1303, "y" : 518 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1303, "y" : 518 } } }, "connectors" : [ ] }, { "id" : 58029, "reactomeId" : 10993929, "displayName" : "PIP3 activates AKT signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1260, "y" : 1129 }, "minX" : 1184, "maxX" : 1336, "minY" : 1097, "maxY" : 1161, "prop" : { "x" : 1184, "y" : 1097, "width" : 152, "height" : 64 }, "textPosition" : { "x" : 1193, "y" : 1107 }, "connectors" : [ ] }, { "id" : 58035, "reactomeId" : 10995543, "displayName" : "RAF/MAP kinase cascade", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1269, "y" : 611 }, "minX" : 1207, "maxX" : 1331, "minY" : 585, "maxY" : 637, "prop" : { "x" : 1207, "y" : 585, "width" : 124, "height" : 52 }, "textPosition" : { "x" : 1210, "y" : 589 }, "connectors" : [ ] }, { "id" : 58036, "reactomeId" : 10995151, "displayName" : "Signaling by Hippo", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 863, "y" : 842 }, "minX" : 812, "maxX" : 915, "minY" : 813, "maxY" : 871, "prop" : { "x" : 812, "y" : 813, "width" : 103, "height" : 58 }, "textPosition" : { "x" : 816, "y" : 820 }, "connectors" : [ ] }, { "id" : 58037, "reactomeId" : 10995159, "displayName" : "YAP1- and WWTR1 (TAZ)-stimulated gene expression", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1014, "y" : 1128 }, "minX" : 943, "maxX" : 1086, "minY" : 1086, "maxY" : 1170, "prop" : { "x" : 943, "y" : 1086, "width" : 143, "height" : 84 }, "textPosition" : { "x" : 948, "y" : 1099 }, "connectors" : [ ] }, { "id" : 58039, "reactomeId" : 10993889, "displayName" : "Activation of NMDA receptors and postsynaptic events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1433, "y" : 44 }, "minX" : 1364, "maxX" : 1503, "minY" : 12, "maxY" : 77, "prop" : { "x" : 1364, "y" : 12, "width" : 139, "height" : 65 }, "textPosition" : { "x" : 1365, "y" : 9 }, "connectors" : [ ] }, { "id" : 57975, "reactomeId" : 179856, "displayName" : "PI(4,5)P2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1265, "y" : 908 }, "minX" : 1234, "maxX" : 1297, "minY" : 892, "maxY" : 943, "prop" : { "x" : 1234, "y" : 893, "width" : 62, "height" : 30 }, "textPosition" : { "x" : 1240, "y" : 891 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1291, "y" : 898 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1291, "y" : 898 } } }, "connectors" : [ { "edgeId" : 57974, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1265, "y" : 926 }, "to" : { "x" : 1265, "y" : 943 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 58040, "reactomeId" : 10946824, "displayName" : "ERBB4jmAcyt1s80 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 483, "y" : 1150 }, "minX" : 424, "maxX" : 549, "minY" : 1127, "maxY" : 1168, "prop" : { "x" : 424, "y" : 1133, "width" : 119, "height" : 35 }, "textPosition" : { "x" : 422, "y" : 1133 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 543, "y" : 1133 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 543, "y" : 1133 } } }, "connectors" : [ ] }, { "id" : 57976, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1213, "y" : 931 }, "minX" : 1194, "maxX" : 1265, "minY" : 922, "maxY" : 943, "prop" : { "x" : 1194, "y" : 923, "width" : 38, "height" : 17 }, "textPosition" : { "x" : 1197, "y" : 921 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1227, "y" : 928 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1227, "y" : 928 } } }, "connectors" : [ { "edgeId" : 57974, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1235, "y" : 935 }, "to" : { "x" : 1265, "y" : 943 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 57977, "reactomeId" : 179838, "displayName" : "PI(3,4,5)P3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1265, "y" : 1022 }, "minX" : 1227, "maxX" : 1304, "minY" : 983, "maxY" : 1037, "prop" : { "x" : 1227, "y" : 1007, "width" : 76, "height" : 30 }, "textPosition" : { "x" : 1234, "y" : 1005 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1298, "y" : 1012 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1298, "y" : 1012 } } }, "connectors" : [ { "edgeId" : 57974, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1265, "y" : 1004 }, "to" : { "x" : 1265, "y" : 983 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1261, "y" : 997 }, "b" : { "x" : 1265, "y" : 1004 }, "c" : { "x" : 1269, "y" : 997 }, "type" : "ARROW", "centre" : { "x" : 1269, "y" : 997 } } } ] }, { "id" : 57978, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1208, "y" : 990 }, "minX" : 1191, "maxX" : 1265, "minY" : 980, "maxY" : 1000, "prop" : { "x" : 1191, "y" : 981, "width" : 34, "height" : 19 }, "textPosition" : { "x" : 1191, "y" : 980 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1220, "y" : 986 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1220, "y" : 986 } } }, "connectors" : [ { "edgeId" : 57974, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1228, "y" : 987 }, "to" : { "x" : 1265, "y" : 983 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1234, "y" : 982 }, "b" : { "x" : 1228, "y" : 987 }, "c" : { "x" : 1235, "y" : 990 }, "type" : "ARROW", "centre" : { "x" : 1235, "y" : 990 } } } ] }, { "id" : 57979, "reactomeId" : 10946725, "displayName" : "PI3K:p-ERBB4cyt1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1257, "y" : 845 }, "minX" : 1200, "maxX" : 1343, "minY" : 829, "maxY" : 962, "prop" : { "x" : 1200, "y" : 835, "width" : 114, "height" : 21 }, "textPosition" : { "x" : 1220, "y" : 821 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1314, "y" : 835 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1314, "y" : 835 } } }, "connectors" : [ { "edgeId" : 57974, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1317, "y" : 845 }, "to" : { "x" : 1341, "y" : 845 } }, { "from" : { "x" : 1341, "y" : 845 }, "to" : { "x" : 1343, "y" : 951 } }, { "from" : { "x" : 1343, "y" : 951 }, "to" : { "x" : 1281, "y" : 957 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1277, "y" : 958 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1277, "y" : 958 } } } ] }, { "id" : 57981, "reactomeId" : 10946753, "displayName" : "ERBB4m80", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 139, "y" : 378 }, "minX" : 102, "maxX" : 177, "minY" : 368, "maxY" : 389, "prop" : { "x" : 102, "y" : 368, "width" : 75, "height" : 21 }, "textPosition" : { "x" : 102, "y" : 368 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 57980, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 57982, "reactomeId" : 10946763, "displayName" : "ERBB4s80", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 337, "y" : 497 }, "minX" : 215, "maxX" : 821, "minY" : 486, "maxY" : 759, "prop" : { "x" : 302, "y" : 486, "width" : 70, "height" : 23 }, "textPosition" : { "x" : 305, "y" : 480 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 57984, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 57994, "type" : "INPUT", "segments" : [ { "from" : { "x" : 378, "y" : 504 }, "to" : { "x" : 821, "y" : 600 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 57997, "type" : "INPUT", "segments" : [ { "from" : { "x" : 363, "y" : 515 }, "to" : { "x" : 797, "y" : 693 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 58002, "type" : "INPUT", "segments" : [ { "from" : { "x" : 353, "y" : 515 }, "to" : { "x" : 718, "y" : 759 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 58007, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 57980, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 58015, "type" : "INPUT", "segments" : [ { "from" : { "x" : 296, "y" : 507 }, "to" : { "x" : 228, "y" : 529 } }, { "from" : { "x" : 228, "y" : 529 }, "to" : { "x" : 215, "y" : 589 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 57983, "reactomeId" : 10946817, "displayName" : "gamma-secretase complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 74, "y" : 432 }, "minX" : 39, "maxX" : 119, "minY" : 402, "maxY" : 505, "prop" : { "x" : 39, "y" : 408, "width" : 70, "height" : 49 }, "textPosition" : { "x" : 42, "y" : 394 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 109, "y" : 408 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 109, "y" : 408 } } }, "connectors" : [ { "edgeId" : 57980, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 88, "y" : 460 }, "to" : { "x" : 113, "y" : 498 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 115, "y" : 501 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 115, "y" : 501 } } } ] } ], "edges" : [ { "id" : 57984, "reactomeId" : 10946834, "displayName" : "Translocation of ERBB4s80 to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 448, "y" : 894 }, "minX" : 340, "maxX" : 563, "minY" : 515, "maxY" : 1114, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 340, "y" : 515 }, "to" : { "x" : 448, "y" : 894 } }, { "from" : { "x" : 448, "y" : 894 }, "to" : { "x" : 447, "y" : 1109 } }, { "from" : { "x" : 447, "y" : 1109 }, "to" : { "x" : 563, "y" : 1114 } } ], "endShape" : { "a" : { "x" : 556, "y" : 1118 }, "b" : { "x" : 563, "y" : 1114 }, "c" : { "x" : 556, "y" : 1110 }, "type" : "ARROW", "centre" : { "x" : 556, "y" : 1110 } }, "reactionShape" : { "a" : { "x" : 442, "y" : 888 }, "b" : { "x" : 454, "y" : 900 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 448, "y" : 894 } }, "inputs" : [ { "id" : 57982 } ], "outputs" : [ { "id" : 57985 } ], "inhibitors" : [ { "id" : 57986, "points" : [ { "x" : 188, "y" : 692 }, { "x" : 240, "y" : 716 }, { "x" : 255, "y" : 892 } ] } ] }, { "id" : 57987, "reactomeId" : 10946846, "displayName" : "ERBB4 binds WWP1/ITCH ubiquitin ligases", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 370, "y" : 253 }, "minX" : 344, "maxX" : 396, "minY" : 247, "maxY" : 259, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 344, "y" : 253 }, "to" : { "x" : 370, "y" : 253 } }, { "from" : { "x" : 370, "y" : 253 }, "to" : { "x" : 396, "y" : 253 } } ], "endShape" : { "a" : { "x" : 389, "y" : 257 }, "b" : { "x" : 396, "y" : 253 }, "c" : { "x" : 389, "y" : 249 }, "type" : "ARROW", "centre" : { "x" : 389, "y" : 249 } }, "reactionShape" : { "c" : { "x" : 370, "y" : 253 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 370, "y" : 253 } }, "inputs" : [ { "id" : 57988, "points" : [ { "x" : 337, "y" : 245 } ] }, { "id" : 57989, "points" : [ { "x" : 224, "y" : 427 } ] } ], "outputs" : [ { "id" : 57990 } ] }, { "id" : 57991, "reactomeId" : 10946844, "displayName" : "ERBB4 ubiquitination by WWP1/ITCH", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 550, "y" : 251 }, "minX" : 530, "maxX" : 579, "minY" : 245, "maxY" : 257, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 530, "y" : 251 }, "to" : { "x" : 550, "y" : 251 } }, { "from" : { "x" : 550, "y" : 251 }, "to" : { "x" : 579, "y" : 251 } } ], "endShape" : { "a" : { "x" : 572, "y" : 255 }, "b" : { "x" : 579, "y" : 251 }, "c" : { "x" : 572, "y" : 247 }, "type" : "ARROW", "centre" : { "x" : 572, "y" : 247 } }, "reactionShape" : { "a" : { "x" : 544, "y" : 245 }, "b" : { "x" : 556, "y" : 257 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 550, "y" : 251 } }, "inputs" : [ { "id" : 57990, "points" : [ { "x" : 513, "y" : 251 } ] }, { "id" : 57992, "points" : [ { "x" : 582, "y" : 299 } ] } ], "outputs" : [ { "id" : 57993 } ], "catalysts" : [ { "id" : 57990, "points" : [ { "x" : 513, "y" : 239 }, { "x" : 550, "y" : 229 } ] } ] }, { "id" : 57994, "reactomeId" : 10946855, "displayName" : "WWOX binds ERBB4s80", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 850, "y" : 600 }, "minX" : 821, "maxX" : 872, "minY" : 594, "maxY" : 606, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 821, "y" : 600 }, "to" : { "x" : 850, "y" : 600 } }, { "from" : { "x" : 850, "y" : 600 }, "to" : { "x" : 872, "y" : 600 } } ], "endShape" : { "a" : { "x" : 865, "y" : 604 }, "b" : { "x" : 872, "y" : 600 }, "c" : { "x" : 865, "y" : 596 }, "type" : "ARROW", "centre" : { "x" : 865, "y" : 596 } }, "reactionShape" : { "c" : { "x" : 850, "y" : 600 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 850, "y" : 600 } }, "inputs" : [ { "id" : 57982, "points" : [ { "x" : 378, "y" : 504 } ] }, { "id" : 57995, "points" : [ { "x" : 806, "y" : 613 } ] } ], "outputs" : [ { "id" : 57996 } ] }, { "id" : 57997, "reactomeId" : 10946870, "displayName" : "ERBB4s80 binds YAP1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 814, "y" : 713 }, "minX" : 797, "maxX" : 888, "minY" : 693, "maxY" : 749, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 797, "y" : 693 }, "to" : { "x" : 814, "y" : 713 } }, { "from" : { "x" : 814, "y" : 713 }, "to" : { "x" : 888, "y" : 749 } } ], "endShape" : { "a" : { "x" : 880, "y" : 750 }, "b" : { "x" : 888, "y" : 749 }, "c" : { "x" : 884, "y" : 742 }, "type" : "ARROW", "centre" : { "x" : 884, "y" : 742 } }, "reactionShape" : { "c" : { "x" : 814, "y" : 713 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 814, "y" : 713 } }, "inputs" : [ { "id" : 57998, "points" : [ { "x" : 761, "y" : 704 } ] }, { "id" : 57982, "points" : [ { "x" : 363, "y" : 515 } ] } ], "outputs" : [ { "id" : 57999 } ] }, { "id" : 58000, "reactomeId" : 10946868, "displayName" : "Translocation of ERBB4s80:YAP1 complex to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 956, "y" : 919 }, "minX" : 929, "maxX" : 962, "minY" : 787, "maxY" : 1028, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 929, "y" : 787 }, "to" : { "x" : 956, "y" : 919 } }, { "from" : { "x" : 956, "y" : 919 }, "to" : { "x" : 942, "y" : 1028 } } ], "endShape" : { "a" : { "x" : 939, "y" : 1021 }, "b" : { "x" : 942, "y" : 1028 }, "c" : { "x" : 947, "y" : 1022 }, "type" : "ARROW", "centre" : { "x" : 947, "y" : 1022 } }, "reactionShape" : { "a" : { "x" : 950, "y" : 913 }, "b" : { "x" : 962, "y" : 925 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 956, "y" : 919 } }, "inputs" : [ { "id" : 57999 } ], "outputs" : [ { "id" : 58001 } ] }, { "id" : 58002, "reactomeId" : 10946901, "displayName" : "ERBB4s80 binds STAT5A", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 730, "y" : 780 }, "minX" : 718, "maxX" : 737, "minY" : 759, "maxY" : 803, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 718, "y" : 759 }, "to" : { "x" : 730, "y" : 780 } }, { "from" : { "x" : 730, "y" : 780 }, "to" : { "x" : 737, "y" : 803 } } ], "endShape" : { "a" : { "x" : 731, "y" : 798 }, "b" : { "x" : 737, "y" : 803 }, "c" : { "x" : 739, "y" : 795 }, "type" : "ARROW", "centre" : { "x" : 739, "y" : 795 } }, "reactionShape" : { "c" : { "x" : 730, "y" : 780 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 730, "y" : 780 } }, "inputs" : [ { "id" : 57982, "points" : [ { "x" : 353, "y" : 515 } ] }, { "id" : 58003, "points" : [ { "x" : 705, "y" : 761 } ] } ], "outputs" : [ { "id" : 58004 } ] }, { "id" : 58005, "reactomeId" : 10946899, "displayName" : "ERBB4s80:STAT5A complex translocates to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 774, "y" : 930 }, "minX" : 751, "maxX" : 780, "minY" : 861, "maxY" : 978, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 751, "y" : 861 }, "to" : { "x" : 774, "y" : 930 } }, { "from" : { "x" : 774, "y" : 930 }, "to" : { "x" : 779, "y" : 978 } } ], "endShape" : { "a" : { "x" : 774, "y" : 972 }, "b" : { "x" : 779, "y" : 978 }, "c" : { "x" : 782, "y" : 971 }, "type" : "ARROW", "centre" : { "x" : 782, "y" : 971 } }, "reactionShape" : { "a" : { "x" : 768, "y" : 924 }, "b" : { "x" : 780, "y" : 936 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 774, "y" : 930 } }, "inputs" : [ { "id" : 58004 } ], "outputs" : [ { "id" : 58006 } ] }, { "id" : 57974, "reactomeId" : 10946728, "displayName" : "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1265, "y" : 959 }, "minX" : 1259, "maxX" : 1271, "minY" : 943, "maxY" : 983, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1265, "y" : 943 }, "to" : { "x" : 1265, "y" : 959 } }, { "from" : { "x" : 1265, "y" : 959 }, "to" : { "x" : 1265, "y" : 983 } } ], "reactionShape" : { "a" : { "x" : 1259, "y" : 953 }, "b" : { "x" : 1271, "y" : 965 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1265, "y" : 959 } }, "inputs" : [ { "id" : 57975, "points" : [ { "x" : 1265, "y" : 926 } ] }, { "id" : 57976, "points" : [ { "x" : 1235, "y" : 935 } ] } ], "outputs" : [ { "id" : 57977, "points" : [ { "x" : 1265, "y" : 1004 } ] }, { "id" : 57978, "points" : [ { "x" : 1228, "y" : 987 } ] } ], "catalysts" : [ { "id" : 57979, "points" : [ { "x" : 1317, "y" : 845 }, { "x" : 1341, "y" : 845 }, { "x" : 1343, "y" : 951 } ] } ] }, { "id" : 58007, "reactomeId" : 10946913, "displayName" : "Translocation of cytosolic ERBB4s80 to mitochondrial matrix", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 547, "y" : 493 }, "minX" : 378, "maxX" : 571, "minY" : 487, "maxY" : 499, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 378, "y" : 496 }, "to" : { "x" : 547, "y" : 493 } }, { "from" : { "x" : 547, "y" : 493 }, "to" : { "x" : 571, "y" : 493 } } ], "endShape" : { "a" : { "x" : 564, "y" : 497 }, "b" : { "x" : 571, "y" : 493 }, "c" : { "x" : 564, "y" : 489 }, "type" : "ARROW", "centre" : { "x" : 564, "y" : 489 } }, "reactionShape" : { "a" : { "x" : 541, "y" : 487 }, "b" : { "x" : 553, "y" : 499 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 547, "y" : 493 } }, "inputs" : [ { "id" : 57982 } ], "outputs" : [ { "id" : 58008 } ] }, { "id" : 58009, "reactomeId" : 10952466, "displayName" : "NEDD4 binds ERBB4jmAcyt1s80 dimer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 446, "y" : 353 }, "minX" : 409, "maxX" : 461, "minY" : 332, "maxY" : 359, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 409, "y" : 354 }, "to" : { "x" : 446, "y" : 353 } }, { "from" : { "x" : 446, "y" : 353 }, "to" : { "x" : 461, "y" : 332 } } ], "endShape" : { "a" : { "x" : 460, "y" : 340 }, "b" : { "x" : 461, "y" : 332 }, "c" : { "x" : 454, "y" : 335 }, "type" : "ARROW", "centre" : { "x" : 454, "y" : 335 } }, "reactionShape" : { "c" : { "x" : 446, "y" : 353 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 446, "y" : 353 } }, "inputs" : [ { "id" : 58010, "points" : [ { "x" : 381, "y" : 329 } ] }, { "id" : 58011, "points" : [ { "x" : 400, "y" : 400 } ] } ], "outputs" : [ { "id" : 58012 } ] }, { "id" : 57980, "reactomeId" : 10946820, "displayName" : "Cleavage of ERBB4m80 by gamma-scretase complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 122, "y" : 511 }, "minX" : 116, "maxX" : 296, "minY" : 395, "maxY" : 517, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 135, "y" : 395 }, "to" : { "x" : 119, "y" : 437 } }, { "from" : { "x" : 119, "y" : 437 }, "to" : { "x" : 122, "y" : 511 } }, { "from" : { "x" : 122, "y" : 511 }, "to" : { "x" : 296, "y" : 499 } } ], "endShape" : { "a" : { "x" : 289, "y" : 503 }, "b" : { "x" : 296, "y" : 499 }, "c" : { "x" : 289, "y" : 495 }, "type" : "ARROW", "centre" : { "x" : 289, "y" : 495 } }, "reactionShape" : { "a" : { "x" : 116, "y" : 505 }, "b" : { "x" : 128, "y" : 517 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 122, "y" : 511 } }, "inputs" : [ { "id" : 57981 } ], "outputs" : [ { "id" : 57982 } ], "catalysts" : [ { "id" : 57983, "points" : [ { "x" : 88, "y" : 460 } ] } ] }, { "id" : 58013, "reactomeId" : 10952471, "displayName" : "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 550, "y" : 365 }, "minX" : 544, "maxX" : 556, "minY" : 344, "maxY" : 397, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 550, "y" : 344 }, "to" : { "x" : 550, "y" : 365 } }, { "from" : { "x" : 550, "y" : 365 }, "to" : { "x" : 551, "y" : 397 } } ], "endShape" : { "a" : { "x" : 547, "y" : 390 }, "b" : { "x" : 551, "y" : 397 }, "c" : { "x" : 555, "y" : 390 }, "type" : "ARROW", "centre" : { "x" : 555, "y" : 390 } }, "reactionShape" : { "a" : { "x" : 544, "y" : 359 }, "b" : { "x" : 556, "y" : 371 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 550, "y" : 365 } }, "inputs" : [ { "id" : 58012, "points" : [ { "x" : 515, "y" : 332 } ] }, { "id" : 57992, "points" : [ { "x" : 578, "y" : 330 } ] } ], "outputs" : [ { "id" : 58014 } ], "catalysts" : [ { "id" : 58012, "points" : [ { "x" : 485, "y" : 332 }, { "x" : 509, "y" : 366 } ] } ] }, { "id" : 58015, "reactomeId" : 10987243, "displayName" : "ERBB4s80 binds to SRC", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 215, "y" : 636 }, "minX" : 188, "maxX" : 221, "minY" : 589, "maxY" : 655, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 215, "y" : 589 }, "to" : { "x" : 215, "y" : 636 } }, { "from" : { "x" : 215, "y" : 636 }, "to" : { "x" : 188, "y" : 655 } } ], "endShape" : { "a" : { "x" : 191, "y" : 648 }, "b" : { "x" : 188, "y" : 655 }, "c" : { "x" : 196, "y" : 654 }, "type" : "ARROW", "centre" : { "x" : 196, "y" : 654 } }, "reactionShape" : { "c" : { "x" : 215, "y" : 636 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 215, "y" : 636 } }, "inputs" : [ { "id" : 58016, "points" : [ { "x" : 190, "y" : 585 }, { "x" : 195, "y" : 586 } ] }, { "id" : 57982, "points" : [ { "x" : 296, "y" : 507 }, { "x" : 228, "y" : 529 } ] } ], "outputs" : [ { "id" : 57986 } ] } ], "compartments" : [ { "id" : 58017, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 787, "y" : 795 }, "minX" : 107, "maxX" : 1467, "minY" : 0, "maxY" : 1591, "prop" : { "x" : 107, "y" : 0, "width" : 1360, "height" : 1591 }, "textPosition" : { "x" : 1097, "y" : 864 }, "insets" : { "x" : 117, "y" : 10, "width" : 1340, "height" : 1571 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 58018, 57988, 57991, 57994, 57997, 57998, 57999, 58003, 58004, 58002, 57995, 57996, 57983, 57987, 58018, 58018, 58028, 57990, 57993, 57981, 57982, 57989, 58045, 58046, 58010, 58011, 58047, 58012, 58009, 58013, 58014, 57992, 58048, 58050, 58018, 58035, 57979, 57975, 57976, 57977, 57978, 58024, 58033, 58051, 58036, 58052, 57974, 58042, 58043, 58029, 58039, 58054, 58015, 58016, 57986, 57980, 58049, 58026, 57984 ] }, { "id" : 58026, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 667, "y" : 1209 }, "minX" : 170, "maxX" : 1165, "minY" : 910, "maxY" : 1508, "prop" : { "x" : 170, "y" : 910, "width" : 995, "height" : 598 }, "textPosition" : { "x" : 1022, "y" : 1464 }, "insets" : { "x" : 180, "y" : 920, "width" : 975, "height" : 578 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 57985, 58001, 58006, 58037, 58053, 58040, 58055, 58000, 58005 ] }, { "id" : 58028, "reactomeId" : 5460, "displayName" : "mitochondrial matrix", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 630, "y" : 502 }, "minX" : 542, "maxX" : 718, "minY" : 457, "maxY" : 548, "prop" : { "x" : 542, "y" : 457, "width" : 176, "height" : 91 }, "textPosition" : { "x" : 561, "y" : 502 }, "insets" : { "x" : 552, "y" : 467, "width" : 156, "height" : 71 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 58008, 58007 ] } ], "notes" : [ ], "links" : [ { "id" : 58051, "renderableClass" : "Interaction", "position" : { "x" : 1269, "y" : 568 }, "minX" : 1263, "maxX" : 1275, "minY" : 555, "maxY" : 582, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1269, "y" : 555 }, "to" : { "x" : 1269, "y" : 582 } } ], "endShape" : { "a" : { "x" : 1265, "y" : 575 }, "b" : { "x" : 1269, "y" : 582 }, "c" : { "x" : 1273, "y" : 575 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1273, "y" : 575 } }, "reactionShape" : { "a" : { "x" : 1263, "y" : 562 }, "b" : { "x" : 1275, "y" : 574 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1269, "y" : 568 } }, "inputs" : [ { "id" : 58024 } ], "outputs" : [ { "id" : 58035 } ] }, { "id" : 58052, "renderableClass" : "Interaction", "position" : { "x" : 791, "y" : 767 }, "minX" : 748, "maxX" : 834, "minY" : 724, "maxY" : 810, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 748, "y" : 724 }, "to" : { "x" : 834, "y" : 810 } } ], "endShape" : { "a" : { "x" : 826, "y" : 808 }, "b" : { "x" : 834, "y" : 810 }, "c" : { "x" : 832, "y" : 802 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 832, "y" : 802 } }, "reactionShape" : { "a" : { "x" : 785, "y" : 761 }, "b" : { "x" : 797, "y" : 773 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 791, "y" : 767 } }, "inputs" : [ { "id" : 57998 } ], "outputs" : [ { "id" : 58036 } ] }, { "id" : 58053, "renderableClass" : "Interaction", "position" : { "x" : 964, "y" : 1076 }, "minX" : 956, "maxX" : 972, "minY" : 1069, "maxY" : 1083, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 956, "y" : 1069 }, "to" : { "x" : 972, "y" : 1083 } } ], "endShape" : { "a" : { "x" : 964, "y" : 1081 }, "b" : { "x" : 972, "y" : 1083 }, "c" : { "x" : 969, "y" : 1075 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 969, "y" : 1075 } }, "reactionShape" : { "a" : { "x" : 958, "y" : 1070 }, "b" : { "x" : 970, "y" : 1082 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 964, "y" : 1076 } }, "inputs" : [ { "id" : 58001 } ], "outputs" : [ { "id" : 58037 } ] }, { "id" : 58055, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 561, "y" : 1136 }, "minX" : 546, "maxX" : 577, "minY" : 1130, "maxY" : 1142, "segments" : [ { "from" : { "x" : 546, "y" : 1139 }, "to" : { "x" : 577, "y" : 1133 } } ], "reactionShape" : { "a" : { "x" : 555, "y" : 1130 }, "b" : { "x" : 567, "y" : 1142 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 561, "y" : 1136 } }, "inputs" : [ { "id" : 58040 } ], "outputs" : [ { "id" : 57985 } ] }, { "id" : 58042, "renderableClass" : "Interaction", "position" : { "x" : 1262, "y" : 1067 }, "minX" : 1256, "maxX" : 1268, "minY" : 1040, "maxY" : 1094, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1264, "y" : 1040 }, "to" : { "x" : 1261, "y" : 1094 } } ], "endShape" : { "a" : { "x" : 1257, "y" : 1087 }, "b" : { "x" : 1261, "y" : 1094 }, "c" : { "x" : 1265, "y" : 1087 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1265, "y" : 1087 } }, "reactionShape" : { "a" : { "x" : 1256, "y" : 1061 }, "b" : { "x" : 1268, "y" : 1073 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1262, "y" : 1067 } }, "inputs" : [ { "id" : 57977 } ], "outputs" : [ { "id" : 58029 } ] }, { "id" : 58044, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 6, "y" : 267 }, "minX" : 0, "maxX" : 147, "minY" : 53, "maxY" : 481, "segments" : [ { "from" : { "x" : 112, "y" : 54 }, "to" : { "x" : 5, "y" : 53 } }, { "from" : { "x" : 5, "y" : 53 }, "to" : { "x" : 7, "y" : 481 } }, { "from" : { "x" : 7, "y" : 481 }, "to" : { "x" : 147, "y" : 459 } } ], "reactionShape" : { "a" : { "x" : 0, "y" : 261 }, "b" : { "x" : 12, "y" : 273 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 6, "y" : 267 } }, "inputs" : [ { "id" : 58018 } ], "outputs" : [ { "id" : 57989 } ] }, { "id" : 58045, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 171, "y" : 411 }, "minX" : 150, "maxX" : 192, "minY" : 395, "maxY" : 427, "segments" : [ { "from" : { "x" : 150, "y" : 395 }, "to" : { "x" : 192, "y" : 427 } } ], "reactionShape" : { "a" : { "x" : 165, "y" : 405 }, "b" : { "x" : 177, "y" : 417 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 171, "y" : 411 } }, "inputs" : [ { "id" : 57981 } ], "outputs" : [ { "id" : 57989 } ] }, { "id" : 58046, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 297, "y" : 474 }, "minX" : 280, "maxX" : 314, "minY" : 468, "maxY" : 480, "segments" : [ { "from" : { "x" : 314, "y" : 480 }, "to" : { "x" : 280, "y" : 468 } } ], "reactionShape" : { "a" : { "x" : 291, "y" : 468 }, "b" : { "x" : 303, "y" : 480 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 297, "y" : 474 } }, "inputs" : [ { "id" : 57982 } ], "outputs" : [ { "id" : 57989 } ] }, { "id" : 58047, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 364, "y" : 460 }, "minX" : 346, "maxX" : 382, "minY" : 441, "maxY" : 480, "segments" : [ { "from" : { "x" : 382, "y" : 441 }, "to" : { "x" : 346, "y" : 480 } } ], "reactionShape" : { "a" : { "x" : 358, "y" : 454 }, "b" : { "x" : 370, "y" : 466 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 364, "y" : 460 } }, "inputs" : [ { "id" : 58011 } ], "outputs" : [ { "id" : 57982 } ] } ], "shadows" : [ { "id" : 58056, "reactomeId" : 10995015, "displayName" : "PI3K events in ERBB4 signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1252, "y" : 936 }, "minX" : 1181, "maxX" : 1324, "minY" : 825, "maxY" : 1047, "prop" : { "x" : 1181, "y" : 825, "width" : 143, "height" : 222 }, "points" : [ { "x" : 1181, "y" : 825 }, { "x" : 1324, "y" : 825 }, { "x" : 1324, "y" : 1047 }, { "x" : 1181, "y" : 1047 } ], "colour" : "#4684ee" }, { "id" : 58057, "reactomeId" : 10995021, "displayName" : "Nuclear signaling by ERBB4", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 507, "y" : 747 }, "minX" : 29, "maxX" : 986, "minY" : 358, "maxY" : 1137, "prop" : { "x" : 29, "y" : 713, "width" : 957, "height" : 424 }, "points" : [ { "x" : 29, "y" : 358 }, { "x" : 986, "y" : 358 }, { "x" : 986, "y" : 1137 }, { "x" : 29, "y" : 1137 } ], "colour" : "#dc3912" }, { "id" : 58058, "reactomeId" : 10995023, "displayName" : "Downregulation of ERBB4 signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 388, "y" : 453 }, "minX" : 104, "maxX" : 672, "minY" : 194, "maxY" : 713, "prop" : { "x" : 104, "y" : 194, "width" : 568, "height" : 164 }, "points" : [ { "x" : 104, "y" : 194 }, { "x" : 672, "y" : 194 }, { "x" : 672, "y" : 713 }, { "x" : 104, "y" : 713 } ], "colour" : "#008000" } ], "minX" : 0, "maxX" : 1503, "minY" : 0, "maxY" : 1591, "disease" : false }