{
  "dbId" : 10443650,
  "stId" : "R-BTA-975155",
  "speciesName" : "Bos taurus",
  "nodes" : [ {
    "dbId" : 10345500,
    "stId" : "R-BTA-205753",
    "displayName" : "UBE2V1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A452DJ78",
    "standardIdentifier" : "uniprot:A0A452DJ78",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBE2V1" ],
    "parents" : [ 10345502 ],
    "children" : [ ]
  }, {
    "dbId" : 10366495,
    "stId" : "R-BTA-936965",
    "displayName" : "K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10366497 ],
    "children" : [ 10344980, 10352621 ]
  }, {
    "dbId" : 10345502,
    "stId" : "R-BTA-202463",
    "displayName" : "UBE2N:UBE2V1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 35274 ],
    "parents" : [ ],
    "children" : [ 10345496, 10345500 ]
  }, {
    "dbId" : 10366493,
    "stId" : "R-BTA-975164",
    "displayName" : "p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 35282 ],
    "parents" : [ 10372053, 10372047, 10366497 ],
    "children" : [ 10366489, 10366491 ]
  }, {
    "dbId" : 10443674,
    "stId" : "R-BTA-450294",
    "displayName" : "MAP kinase activation",
    "schemaClass" : "Pathway",
    "speciesId" : 48898,
    "diagramIds" : [ 35321 ]
  }, {
    "dbId" : 10345496,
    "stId" : "R-BTA-206072",
    "displayName" : "UBE2N [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q0P5K3",
    "standardIdentifier" : "uniprot:Q0P5K3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBE2N" ],
    "parents" : [ 10345502 ],
    "children" : [ ]
  }, {
    "dbId" : 10366491,
    "stId" : "R-BTA-975187",
    "displayName" : "phospho-p-IRAK2 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q0P5I2",
    "standardIdentifier" : "uniprot:Q0P5I2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10372081, 10366493 ],
    "children" : [ ]
  }, {
    "dbId" : 10366489,
    "stId" : "R-BTA-450227",
    "displayName" : "TRAF6 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q3ZCC3",
    "standardIdentifier" : "uniprot:Q3ZCC3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TRAF6" ],
    "parents" : [ 10366493 ],
    "children" : [ ]
  }, {
    "dbId" : 10347413,
    "stId" : "R-BTA-450270",
    "displayName" : "phospho-p-S477,S479-IRF7 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1MWF9",
    "standardIdentifier" : "uniprot:A0A3Q1MWF9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10347415 ],
    "children" : [ ]
  }, {
    "dbId" : 10344980,
    "stId" : "R-BTA-166172",
    "displayName" : "TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10366495 ],
    "children" : [ 10344978, 10344936 ]
  }, {
    "dbId" : 10347415,
    "stId" : "R-BTA-450306",
    "displayName" : "2xp-S477,S479-IRF7 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 35294 ],
    "parents" : [ ],
    "children" : [ 10347413 ]
  }, {
    "dbId" : 10344978,
    "stId" : "R-BTA-166170",
    "displayName" : "Ghost homologue of TICAM1 [cytosol]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 48898,
    "parents" : [ 10344980 ],
    "children" : [ ]
  }, {
    "dbId" : 10366732,
    "stId" : "R-BTA-450819",
    "displayName" : "p-Pellino-1,2,(3) [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48898,
    "diagramIds" : [ 35277, 35263 ],
    "parents" : [ 10372071 ],
    "children" : [ 10366724, 10366727, 10366730 ]
  }, {
    "dbId" : 10366730,
    "stId" : "R-BTA-450806",
    "displayName" : "phospho-PELI3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1MK28",
    "standardIdentifier" : "uniprot:A0A3Q1MK28",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PELI3" ],
    "parents" : [ 10366732 ],
    "children" : [ ]
  }, {
    "dbId" : 10350219,
    "stId" : "R-BTA-168104",
    "displayName" : "CHUK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q95KV1",
    "standardIdentifier" : "uniprot:Q95KV1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10352645 ],
    "children" : [ ]
  }, {
    "dbId" : 10352645,
    "stId" : "R-BTA-168113",
    "displayName" : "CHUK:IKBKB:IKBKG [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 35279 ],
    "parents" : [ 10372063 ],
    "children" : [ 10349376, 10350219, 10345310 ]
  }, {
    "dbId" : 10366727,
    "stId" : "R-BTA-450825",
    "displayName" : "phospho-p-PELI2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MNJ6",
    "standardIdentifier" : "uniprot:F1MNJ6",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10366732 ],
    "children" : [ ]
  }, {
    "dbId" : 10366724,
    "stId" : "R-BTA-450815",
    "displayName" : "phospho-PELI1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0JN70",
    "standardIdentifier" : "uniprot:A0JN70",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PELI1" ],
    "parents" : [ 10366732 ],
    "children" : [ ]
  }, {
    "dbId" : 10345472,
    "stId" : "R-BTA-450152",
    "displayName" : "K63polyUb [cytosol]",
    "schemaClass" : "Polymer",
    "speciesId" : 48898,
    "diagramIds" : [ 35259, 35275 ],
    "parents" : [ 10372047, 10372053 ],
    "children" : [ 10345470 ]
  }, {
    "dbId" : 10365756,
    "stId" : "R-BTA-168117",
    "displayName" : "TAB2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1B7Z0",
    "standardIdentifier" : "uniprot:E1B7Z0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TAB2" ],
    "parents" : [ 10365762 ],
    "children" : [ ]
  }, {
    "dbId" : 10365754,
    "stId" : "R-BTA-167923",
    "displayName" : "TAB1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F6QID7",
    "standardIdentifier" : "uniprot:F6QID7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TAB1" ],
    "parents" : [ 10365764 ],
    "children" : [ ]
  }, {
    "dbId" : 10345018,
    "stId" : "R-BTA-450318",
    "displayName" : "phospho-p-S477,S479-IRF7 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 35291 ],
    "identifier" : "A0A3Q1MWF9",
    "standardIdentifier" : "uniprot:A0A3Q1MWF9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10345525 ],
    "children" : [ ]
  }, {
    "dbId" : 10345525,
    "stId" : "R-BTA-450344",
    "displayName" : "p-2S-IRF7:p-2S-IRF7 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 35292 ],
    "parents" : [ ],
    "children" : [ 10345018 ]
  }, {
    "dbId" : 10365750,
    "stId" : "R-BTA-168156",
    "displayName" : "MAP3K7 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A2VDU3",
    "standardIdentifier" : "uniprot:A2VDU3",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10365764 ],
    "children" : [ ]
  }, {
    "dbId" : 10443702,
    "stId" : "R-BTA-445989",
    "displayName" : "TAK1-dependent IKK and NF-kappa-B activation  ",
    "schemaClass" : "Pathway",
    "speciesId" : 48898,
    "diagramIds" : [ 35320 ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 35270, 35287 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 35272, 35288 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10366499,
    "stId" : "R-BTA-450272",
    "displayName" : "TRAF6 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q3ZCC3",
    "standardIdentifier" : "uniprot:Q3ZCC3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TRAF6" ],
    "parents" : [ 10372069, 10372061, 10372083, 10372081 ],
    "children" : [ ]
  }, {
    "dbId" : 10366497,
    "stId" : "R-BTA-975153",
    "displayName" : "K63-linked polyUb TRAF6 complexes [endosome membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 35260 ],
    "parents" : [ ],
    "children" : [ 10366493, 10366495 ]
  }, {
    "dbId" : 10372063,
    "stId" : "R-BTA-975121",
    "displayName" : "TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 35280 ],
    "parents" : [ ],
    "children" : [ 10352645, 10372061 ]
  }, {
    "dbId" : 10344924,
    "stId" : "R-BTA-2201336",
    "displayName" : "phospho-TICAM2 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q2LGB7",
    "standardIdentifier" : "uniprot:Q2LGB7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TICAM2" ],
    "parents" : [ 10344936 ],
    "children" : [ ]
  }, {
    "dbId" : 10372061,
    "stId" : "R-BTA-975172",
    "displayName" : "K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 35276 ],
    "parents" : [ 10372063 ],
    "children" : [ 10366499, 10372059 ]
  }, {
    "dbId" : 10345310,
    "stId" : "R-BTA-168108",
    "displayName" : "IKBKG [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q95KU9",
    "standardIdentifier" : "uniprot:Q95KU9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10352645 ],
    "children" : [ ]
  }, {
    "dbId" : 10344926,
    "stId" : "R-BTA-2201284",
    "displayName" : "CD14 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A6QNL0",
    "standardIdentifier" : "uniprot:A6QNL0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CD14" ],
    "parents" : [ 10344934 ],
    "children" : [ ]
  }, {
    "dbId" : 10333273,
    "stId" : "R-BTA-939188",
    "displayName" : "UBC [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P0CH28",
    "standardIdentifier" : "uniprot:P0CH28",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBC" ],
    "parents" : [ 10333291 ],
    "children" : [ ]
  }, {
    "dbId" : 10345432,
    "stId" : "R-BTA-939169",
    "displayName" : "UBA52 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P63048",
    "standardIdentifier" : "uniprot:P63048",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBA52" ],
    "parents" : [ 10345470 ],
    "children" : [ ]
  }, {
    "dbId" : 10372059,
    "stId" : "R-BTA-975112",
    "displayName" : "phospho-K63polyUb-hp-IRAK1 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q2LGB3",
    "standardIdentifier" : "uniprot:Q2LGB3",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10372061 ],
    "children" : [ ]
  }, {
    "dbId" : 10345435,
    "stId" : "R-BTA-939224",
    "displayName" : "RPS27A [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P62992",
    "standardIdentifier" : "uniprot:P62992",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RPS27A" ],
    "parents" : [ 10345470 ],
    "children" : [ ]
  }, {
    "dbId" : 10345178,
    "stId" : "R-BTA-168064",
    "displayName" : "ECSIT [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 35298 ],
    "identifier" : "Q3SX05",
    "standardIdentifier" : "uniprot:Q3SX05",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ECSIT" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10345429,
    "stId" : "R-BTA-939248",
    "displayName" : "UBB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P0CG53",
    "standardIdentifier" : "uniprot:P0CG53",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBB" ],
    "parents" : [ 10345470 ],
    "children" : [ ]
  }, {
    "dbId" : 10345172,
    "stId" : "R-BTA-166366",
    "displayName" : "TRAF6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 35267 ],
    "identifier" : "Q3ZCC3",
    "standardIdentifier" : "uniprot:Q3ZCC3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TRAF6" ],
    "parents" : [ 10345174 ],
    "children" : [ ]
  }, {
    "dbId" : 10345174,
    "stId" : "R-BTA-166867",
    "displayName" : "MEKK1:activated TRAF6 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 35297 ],
    "parents" : [ ],
    "children" : [ 10345168, 10345172 ]
  }, {
    "dbId" : 10372053,
    "stId" : "R-BTA-975171",
    "displayName" : "p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 35289 ],
    "parents" : [ ],
    "children" : [ 10372051, 10345472, 10372039, 10372043, 10366493 ]
  }, {
    "dbId" : 10333265,
    "stId" : "R-BTA-939203",
    "displayName" : "UBA52 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P63048",
    "standardIdentifier" : "uniprot:P63048",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBA52" ],
    "parents" : [ 10333291 ],
    "children" : [ ]
  }, {
    "dbId" : 10345168,
    "stId" : "R-BTA-166866",
    "displayName" : "MAP3K1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 35296 ],
    "identifier" : "E1B847",
    "standardIdentifier" : "uniprot:E1B847",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10345174 ],
    "children" : [ ]
  }, {
    "dbId" : 10372051,
    "stId" : "R-BTA-450332",
    "displayName" : "phospho-p-T184,T187-MAP3K7 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A2VDU3",
    "standardIdentifier" : "uniprot:A2VDU3",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10372053 ],
    "children" : [ ]
  }, {
    "dbId" : 10333267,
    "stId" : "R-BTA-939214",
    "displayName" : "RPS27A [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P62992",
    "standardIdentifier" : "uniprot:P62992",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RPS27A" ],
    "parents" : [ 10333291 ],
    "children" : [ ]
  }, {
    "dbId" : 10372047,
    "stId" : "R-BTA-975099",
    "displayName" : "p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 35285 ],
    "parents" : [ ],
    "children" : [ 10345472, 10372045, 10366493 ]
  }, {
    "dbId" : 10333263,
    "stId" : "R-BTA-939205",
    "displayName" : "UBB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P0CG53",
    "standardIdentifier" : "uniprot:P0CG53",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBB" ],
    "parents" : [ 10333291 ],
    "children" : [ ]
  }, {
    "dbId" : 10372045,
    "stId" : "R-BTA-975128",
    "displayName" : "TAK1 complex [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10372047 ],
    "children" : [ 10372039, 10372041, 10372043 ]
  }, {
    "dbId" : 10372043,
    "stId" : "R-BTA-450238",
    "displayName" : "TAB1 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F6QID7",
    "standardIdentifier" : "uniprot:F6QID7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TAB1" ],
    "parents" : [ 10372053, 10372045 ],
    "children" : [ ]
  }, {
    "dbId" : 10372041,
    "stId" : "R-BTA-450315",
    "displayName" : "MAP3K7 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A2VDU3",
    "standardIdentifier" : "uniprot:A2VDU3",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10372045 ],
    "children" : [ ]
  }, {
    "dbId" : 10372039,
    "stId" : "R-BTA-975101",
    "displayName" : "TAB2/3 [endosome membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "parents" : [ 10372053, 10372045 ],
    "children" : [ 10372035, 10372037 ]
  }, {
    "dbId" : 10365764,
    "stId" : "R-BTA-446878",
    "displayName" : "TAK1 complex [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 35284 ],
    "parents" : [ ],
    "children" : [ 10365762, 10365750, 10365754 ]
  }, {
    "dbId" : 10372037,
    "stId" : "R-BTA-450247",
    "displayName" : "TAB3 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1M7T8",
    "standardIdentifier" : "uniprot:A0A3Q1M7T8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TAB3" ],
    "parents" : [ 10372039 ],
    "children" : [ ]
  }, {
    "dbId" : 10365762,
    "stId" : "R-BTA-446874",
    "displayName" : "TAB2,TAB3 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "parents" : [ 10365764 ],
    "children" : [ 10365760, 10365756 ]
  }, {
    "dbId" : 10349376,
    "stId" : "R-BTA-168114",
    "displayName" : "IKBKB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q95KV0",
    "standardIdentifier" : "uniprot:Q95KV0",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10352645 ],
    "children" : [ ]
  }, {
    "dbId" : 10372035,
    "stId" : "R-BTA-450279",
    "displayName" : "TAB2 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1B7Z0",
    "standardIdentifier" : "uniprot:E1B7Z0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TAB2" ],
    "parents" : [ 10372039 ],
    "children" : [ ]
  }, {
    "dbId" : 10365760,
    "stId" : "R-BTA-450264",
    "displayName" : "TAB3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1M7T8",
    "standardIdentifier" : "uniprot:A0A3Q1M7T8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TAB3" ],
    "parents" : [ 10365762 ],
    "children" : [ ]
  }, {
    "dbId" : 10345470,
    "stId" : "R-BTA-450143",
    "displayName" : "K63-Ub [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "parents" : [ 10345472 ],
    "children" : [ 10345444, 10345429, 10345435, 10345432 ]
  }, {
    "dbId" : 10372083,
    "stId" : "R-BTA-975137",
    "displayName" : "p-IRAK2:oligo-TRAF6 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 35268 ],
    "parents" : [ ],
    "children" : [ 10372081, 10366499 ]
  }, {
    "dbId" : 10372081,
    "stId" : "R-BTA-975108",
    "displayName" : "TRAF6:p-IRAK2 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 35266 ],
    "parents" : [ 10372083 ],
    "children" : [ 10366499, 10366491 ]
  }, {
    "dbId" : 10352621,
    "stId" : "R-BTA-2685681",
    "displayName" : "TRAF6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q3ZCC3",
    "standardIdentifier" : "uniprot:Q3ZCC3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TRAF6" ],
    "parents" : [ 10366495 ],
    "children" : [ ]
  }, {
    "dbId" : 10344936,
    "stId" : "R-BTA-166163",
    "displayName" : "TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10344980 ],
    "children" : [ 10344934, 10344924 ]
  }, {
    "dbId" : 10333291,
    "stId" : "R-BTA-113595",
    "displayName" : "Ub [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 35258 ],
    "parents" : [ ],
    "children" : [ 10333263, 10333273, 10333265, 10333267 ]
  }, {
    "dbId" : 10372071,
    "stId" : "R-BTA-975166",
    "displayName" : "p-Pellino:hp-IRAK1:TRAF6 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 35264, 35271 ],
    "parents" : [ ],
    "children" : [ 10372069, 10366732 ]
  }, {
    "dbId" : 10345444,
    "stId" : "R-BTA-939176",
    "displayName" : "UBC [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P0CH28",
    "standardIdentifier" : "uniprot:P0CH28",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBC" ],
    "parents" : [ 10345470 ],
    "children" : [ ]
  }, {
    "dbId" : 10344932,
    "stId" : "R-BTA-2201291",
    "displayName" : "TLR4:LY96 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10344934 ],
    "children" : [ 10344930, 10344928 ]
  }, {
    "dbId" : 10372069,
    "stId" : "R-BTA-975150",
    "displayName" : "TRAF6:hp-IRAK1 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 35262 ],
    "parents" : [ 10372071 ],
    "children" : [ 10372067, 10366499 ]
  }, {
    "dbId" : 10344934,
    "stId" : "R-BTA-2201299",
    "displayName" : "TLR4:LY96:LPS:CD14 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10344936 ],
    "children" : [ 2201311, 10344932, 10344926 ]
  }, {
    "dbId" : 10372067,
    "stId" : "R-BTA-975157",
    "displayName" : "phospho-p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q2LGB3",
    "standardIdentifier" : "uniprot:Q2LGB3",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10372069 ],
    "children" : [ ]
  }, {
    "dbId" : 10344928,
    "stId" : "R-BTA-2201307",
    "displayName" : "LY96 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "C4T7Z1",
    "standardIdentifier" : "uniprot:C4T7Z1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LY96" ],
    "parents" : [ 10344932 ],
    "children" : [ ]
  }, {
    "dbId" : 2201311,
    "stId" : "R-ALL-2201311",
    "displayName" : "LPS [endosome lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "16412",
    "standardIdentifier" : "chebi:16412",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10344934 ],
    "children" : [ ]
  }, {
    "dbId" : 10344930,
    "stId" : "R-BTA-2201285",
    "displayName" : "TLR4 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q6WCD5",
    "standardIdentifier" : "uniprot:Q6WCD5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TLR4" ],
    "parents" : [ 10344932 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10345180,
    "stId" : "R-BTA-166869",
    "displayName" : "TRAF6 binds MEKK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10345168, 10345172 ],
    "outputs" : [ 10345174 ],
    "efs" : [ ],
    "requirements" : [ 10345178 ],
    "diagramIds" : [ 35295 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10372079,
    "stId" : "R-BTA-975142",
    "displayName" : "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10372077 ],
    "inputs" : [ 10372069, 10366732 ],
    "outputs" : [ 10372071 ],
    "efs" : [ ],
    "diagramIds" : [ 35261 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10372077,
    "stId" : "R-BTA-975139",
    "displayName" : "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation ",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10372079 ],
    "following" : [ 10372074 ],
    "inputs" : [ 10372071, 113592 ],
    "outputs" : [ 29370, 10372071 ],
    "catalysts" : [ 10372071 ],
    "efs" : [ ],
    "diagramIds" : [ 35269 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10372074,
    "stId" : "R-BTA-975122",
    "displayName" : "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br>",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10372077 ],
    "following" : [ 10372065 ],
    "inputs" : [ 10345472, 10372071, 10345502 ],
    "outputs" : [ 10372061, 10345502, 10366732 ],
    "catalysts" : [ 10372071 ],
    "efs" : [ ],
    "diagramIds" : [ 35273 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10372088,
    "stId" : "R-BTA-975185",
    "displayName" : "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10372086 ],
    "inputs" : [ 10372081, 10345172 ],
    "outputs" : [ 10372083 ],
    "efs" : [ ],
    "diagramIds" : [ 35265 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10370409,
    "stId" : "R-BTA-933533",
    "displayName" : "Dimerization of p-IRF7",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10370407 ],
    "inputs" : [ 10345018 ],
    "outputs" : [ 10345525 ],
    "efs" : [ ],
    "diagramIds" : [ 35290 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10372086,
    "stId" : "R-BTA-975147",
    "displayName" : "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10372088 ],
    "following" : [ 10372049, 10366502 ],
    "inputs" : [ 10372083, 10333291 ],
    "outputs" : [ 10366493 ],
    "catalysts" : [ 10372083 ],
    "efs" : [ ],
    "diagramIds" : [ 35281 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10366502,
    "stId" : "R-BTA-450358",
    "displayName" : "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation ",
    "schemaClass" : "Polymerisation",
    "speciesId" : 0,
    "preceding" : [ 10372086 ],
    "following" : [ 10372049 ],
    "inputs" : [ 10333291 ],
    "outputs" : [ 10345472 ],
    "catalysts" : [ 10366497 ],
    "efs" : [ ],
    "diagramIds" : [ 35257 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10370407,
    "stId" : "R-BTA-933531",
    "displayName" : "Translocation of p-IRF7:p-IRF7 to nucleus",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10370409 ],
    "inputs" : [ 10345525 ],
    "outputs" : [ 10347415 ],
    "efs" : [ ],
    "diagramIds" : [ 35293 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10372055,
    "stId" : "R-BTA-975103",
    "displayName" : "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10372049 ],
    "inputs" : [ 113592, 10372047 ],
    "outputs" : [ 10372053, 29370 ],
    "efs" : [ ],
    "diagramIds" : [ 35286 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10372065,
    "stId" : "R-BTA-975119",
    "displayName" : "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10372074 ],
    "inputs" : [ 10352645, 10372061 ],
    "outputs" : [ 10372063 ],
    "efs" : [ ],
    "diagramIds" : [ 35278 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10372049,
    "stId" : "R-BTA-975097",
    "displayName" : "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10372086, 10366502 ],
    "following" : [ 10372055 ],
    "inputs" : [ 10345472, 10365764, 10366493 ],
    "outputs" : [ 10372047 ],
    "efs" : [ ],
    "diagramIds" : [ 35283 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10444724,
    "stId" : "R-BTA-975163",
    "displayName" : "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation",
    "events" : [ 10372088, 10372086, 10366502, 10372055, 10372049 ]
  }, {
    "dbId" : 10444868,
    "stId" : "R-BTA-975144",
    "displayName" : "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation",
    "events" : [ 10372079, 10372077, 10372074, 10372065 ]
  }, {
    "dbId" : 10443648,
    "stId" : "R-BTA-975138",
    "displayName" : "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation",
    "events" : [ 10345180, 10372079, 10372077, 10372074, 10372065, 10372088, 10372086, 10366502, 10372055, 10372049 ]
  }, {
    "dbId" : 10444842,
    "stId" : "R-BTA-975110",
    "displayName" : "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling",
    "events" : [ 10370409, 10370407 ]
  } ]
}