{ "dbId" : 10444316, "stableId" : "R-BTA-373076", "displayName" : "Class A/1 (Rhodopsin-like receptors)", "nodes" : [ { "id" : 133123, "reactomeId" : 10370857, "displayName" : "C5AR2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 654, "y" : 1785 }, "minX" : 630, "maxX" : 691, "minY" : 1768, "maxY" : 1799, "prop" : { "x" : 630, "y" : 1774, "width" : 48, "height" : 23 }, "textPosition" : { "x" : 630, "y" : 1775 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 678, "y" : 1774 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 678, "y" : 1774 } } }, "connectors" : [ { "edgeId" : 133122, "type" : "INPUT", "segments" : [ { "from" : { "x" : 681, "y" : 1794 }, "to" : { "x" : 691, "y" : 1799 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133120, "reactomeId" : 10358803, "displayName" : "GPR18", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 610, "y" : 2234 }, "minX" : 581, "maxX" : 647, "minY" : 2215, "maxY" : 2256, "prop" : { "x" : 581, "y" : 2221, "width" : 59, "height" : 26 }, "textPosition" : { "x" : 586, "y" : 2223 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 640, "y" : 2221 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 640, "y" : 2221 } } }, "connectors" : [ { "edgeId" : 133118, "type" : "INPUT", "segments" : [ { "from" : { "x" : 631, "y" : 2250 }, "to" : { "x" : 647, "y" : 2256 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133121, "reactomeId" : 10358805, "displayName" : "GPR18:NAGLY", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 737, "y" : 2234 }, "minX" : 689, "maxX" : 791, "minY" : 2216, "maxY" : 2247, "prop" : { "x" : 689, "y" : 2222, "width" : 96, "height" : 25 }, "textPosition" : { "x" : 691, "y" : 2226 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 785, "y" : 2222 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 785, "y" : 2222 } } }, "connectors" : [ { "edgeId" : 133118, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133127, "reactomeId" : 10358470, "displayName" : "MCHR1,MCHR2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 856, "y" : 2222 }, "minX" : 822, "maxX" : 912, "minY" : 2199, "maxY" : 2245, "prop" : { "x" : 822, "y" : 2199, "width" : 69, "height" : 46 }, "textPosition" : { "x" : 829, "y" : 2204 }, "connectors" : [ { "edgeId" : 133126, "type" : "INPUT", "segments" : [ { "from" : { "x" : 897, "y" : 2233 }, "to" : { "x" : 912, "y" : 2240 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133124, "reactomeId" : 10370853, "displayName" : "C5AR2 ligands", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 650, "y" : 1835 }, "minX" : 617, "maxX" : 691, "minY" : 1799, "maxY" : 1850, "prop" : { "x" : 617, "y" : 1821, "width" : 66, "height" : 29 }, "textPosition" : { "x" : 623, "y" : 1818 }, "connectors" : [ { "edgeId" : 133122, "type" : "INPUT", "segments" : [ { "from" : { "x" : 666, "y" : 1815 }, "to" : { "x" : 691, "y" : 1799 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133125, "reactomeId" : 10370859, "displayName" : "C5AR2:C5AR2 ligands", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 788, "y" : 1783 }, "minX" : 740, "maxX" : 843, "minY" : 1759, "maxY" : 1802, "prop" : { "x" : 740, "y" : 1765, "width" : 97, "height" : 37 }, "textPosition" : { "x" : 740, "y" : 1767 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 837, "y" : 1765 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 837, "y" : 1765 } } }, "connectors" : [ { "edgeId" : 133122, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133131, "reactomeId" : 10358496, "displayName" : "NMU", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1154, "y" : 2284 }, "minX" : 1125, "maxX" : 1190, "minY" : 2261, "maxY" : 2298, "prop" : { "x" : 1125, "y" : 2271, "width" : 59, "height" : 27 }, "textPosition" : { "x" : 1136, "y" : 2274 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1184, "y" : 2271 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1184, "y" : 2271 } } }, "connectors" : [ { "edgeId" : 133130, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1172, "y" : 2268 }, "to" : { "x" : 1185, "y" : 2261 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133128, "reactomeId" : 10358474, "displayName" : "PMCH", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 849, "y" : 2275 }, "minX" : 812, "maxX" : 912, "minY" : 2240, "maxY" : 2293, "prop" : { "x" : 812, "y" : 2258, "width" : 75, "height" : 35 }, "textPosition" : { "x" : 828, "y" : 2265 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 887, "y" : 2258 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 887, "y" : 2258 } } }, "connectors" : [ { "edgeId" : 133126, "type" : "INPUT", "segments" : [ { "from" : { "x" : 880, "y" : 2255 }, "to" : { "x" : 912, "y" : 2240 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133129, "reactomeId" : 10358476, "displayName" : "MCHR1,MCHR2:PMCH(147-165)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1033, "y" : 2233 }, "minX" : 971, "maxX" : 1101, "minY" : 2209, "maxY" : 2252, "prop" : { "x" : 971, "y" : 2215, "width" : 124, "height" : 37 }, "textPosition" : { "x" : 980, "y" : 2217 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1095, "y" : 2215 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1095, "y" : 2215 } } }, "connectors" : [ { "edgeId" : 133126, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133135, "reactomeId" : 10358480, "displayName" : "NMUR2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1448, "y" : 2230 }, "minX" : 1409, "maxX" : 1494, "minY" : 2211, "maxY" : 2247, "prop" : { "x" : 1409, "y" : 2217, "width" : 79, "height" : 26 }, "textPosition" : { "x" : 1422, "y" : 2219 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1488, "y" : 2217 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1488, "y" : 2217 } } }, "connectors" : [ { "edgeId" : 133134, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1480, "y" : 2246 }, "to" : { "x" : 1491, "y" : 2247 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133132, "reactomeId" : 10358492, "displayName" : "NMUR1,NMUR2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1159, "y" : 2228 }, "minX" : 1118, "maxX" : 1201, "minY" : 2210, "maxY" : 2261, "prop" : { "x" : 1118, "y" : 2210, "width" : 83, "height" : 37 }, "textPosition" : { "x" : 1131, "y" : 2211 }, "connectors" : [ { "edgeId" : 133130, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1173, "y" : 2253 }, "to" : { "x" : 1185, "y" : 2261 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133133, "reactomeId" : 10358498, "displayName" : "NMUR1,NMUR2:NMU", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1328, "y" : 2233 }, "minX" : 1273, "maxX" : 1390, "minY" : 2209, "maxY" : 2252, "prop" : { "x" : 1273, "y" : 2215, "width" : 111, "height" : 37 }, "textPosition" : { "x" : 1276, "y" : 2217 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1384, "y" : 2215 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1384, "y" : 2215 } } }, "connectors" : [ { "edgeId" : 133130, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133139, "reactomeId" : 373863, "displayName" : "LACT", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1408, "y" : 1903 }, "minX" : 1385, "maxX" : 1452, "minY" : 1888, "maxY" : 1929, "prop" : { "x" : 1385, "y" : 1889, "width" : 46, "height" : 29 }, "textPosition" : { "x" : 1389, "y" : 1893 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1426, "y" : 1894 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1426, "y" : 1894 } } }, "connectors" : [ { "edgeId" : 133138, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1434, "y" : 1916 }, "to" : { "x" : 1452, "y" : 1929 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133136, "reactomeId" : 10358484, "displayName" : "NMS", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1447, "y" : 2271 }, "minX" : 1419, "maxX" : 1491, "minY" : 2247, "maxY" : 2283, "prop" : { "x" : 1419, "y" : 2260, "width" : 57, "height" : 23 }, "textPosition" : { "x" : 1430, "y" : 2261 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1476, "y" : 2260 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1476, "y" : 2260 } } }, "connectors" : [ { "edgeId" : 133134, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1468, "y" : 2257 }, "to" : { "x" : 1491, "y" : 2247 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133137, "reactomeId" : 10358486, "displayName" : "NMUR2:NMS", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1588, "y" : 2234 }, "minX" : 1545, "maxX" : 1638, "minY" : 2215, "maxY" : 2248, "prop" : { "x" : 1545, "y" : 2221, "width" : 87, "height" : 27 }, "textPosition" : { "x" : 1547, "y" : 2227 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1632, "y" : 2221 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1632, "y" : 2221 } } }, "connectors" : [ { "edgeId" : 133134, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133143, "reactomeId" : 10358927, "displayName" : "HCAR3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1094, "y" : 1968 }, "minX" : 1062, "maxX" : 1135, "minY" : 1930, "maxY" : 1979, "prop" : { "x" : 1062, "y" : 1957, "width" : 64, "height" : 22 }, "textPosition" : { "x" : 1069, "y" : 1957 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1126, "y" : 1957 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1126, "y" : 1957 } } }, "connectors" : [ { "edgeId" : 133142, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1105, "y" : 1954 }, "to" : { "x" : 1135, "y" : 1930 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133140, "reactomeId" : 10358917, "displayName" : "HCAR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1417, "y" : 1969 }, "minX" : 1385, "maxX" : 1455, "minY" : 1929, "maxY" : 1980, "prop" : { "x" : 1385, "y" : 1958, "width" : 64, "height" : 22 }, "textPosition" : { "x" : 1392, "y" : 1958 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1449, "y" : 1958 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1449, "y" : 1958 } } }, "connectors" : [ { "edgeId" : 133138, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1426, "y" : 1955 }, "to" : { "x" : 1452, "y" : 1929 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133141, "reactomeId" : 10358919, "displayName" : "HCAR1:LACT", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1516, "y" : 1972 }, "minX" : 1473, "maxX" : 1566, "minY" : 1955, "maxY" : 1983, "prop" : { "x" : 1473, "y" : 1961, "width" : 87, "height" : 22 }, "textPosition" : { "x" : 1475, "y" : 1962 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1560, "y" : 1961 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1560, "y" : 1961 } } }, "connectors" : [ { "edgeId" : 133138, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133147, "reactomeId" : 3296298, "displayName" : "12(S)-HETE", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3821, "y" : 1918 }, "minX" : 3776, "maxX" : 3867, "minY" : 1902, "maxY" : 1945, "prop" : { "x" : 3776, "y" : 1903, "width" : 90, "height" : 30 }, "textPosition" : { "x" : 3782, "y" : 1907 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3861, "y" : 1908 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3861, "y" : 1908 } } }, "connectors" : [ { "edgeId" : 133146, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3840, "y" : 1936 }, "to" : { "x" : 3856, "y" : 1945 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133144, "reactomeId" : 3296330, "displayName" : "HCAR3 ligands", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1081, "y" : 1904 }, "minX" : 1018, "maxX" : 1145, "minY" : 1889, "maxY" : 1930, "prop" : { "x" : 1018, "y" : 1889, "width" : 127, "height" : 30 }, "textPosition" : { "x" : 1032, "y" : 1893 }, "connectors" : [ { "edgeId" : 133142, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1112, "y" : 1925 }, "to" : { "x" : 1135, "y" : 1930 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133145, "reactomeId" : 10358929, "displayName" : "HCAR3:HCAR3 ligands", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1219, "y" : 1968 }, "minX" : 1162, "maxX" : 1283, "minY" : 1943, "maxY" : 1988, "prop" : { "x" : 1162, "y" : 1949, "width" : 115, "height" : 39 }, "textPosition" : { "x" : 1170, "y" : 1953 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1277, "y" : 1949 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1277, "y" : 1949 } } }, "connectors" : [ { "edgeId" : 133142, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133151, "reactomeId" : 561075, "displayName" : "2OG", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1698, "y" : 2288 }, "minX" : 1673, "maxX" : 1726, "minY" : 2251, "maxY" : 2303, "prop" : { "x" : 1673, "y" : 2273, "width" : 50, "height" : 30 }, "textPosition" : { "x" : 1681, "y" : 2277 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1718, "y" : 2278 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1718, "y" : 2278 } } }, "connectors" : [ { "edgeId" : 133150, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1709, "y" : 2270 }, "to" : { "x" : 1726, "y" : 2251 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133148, "reactomeId" : 10358977, "displayName" : "GPR31", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3820, "y" : 1975 }, "minX" : 3788, "maxX" : 3858, "minY" : 1945, "maxY" : 1986, "prop" : { "x" : 3788, "y" : 1964, "width" : 64, "height" : 22 }, "textPosition" : { "x" : 3795, "y" : 1964 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3852, "y" : 1964 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3852, "y" : 1964 } } }, "connectors" : [ { "edgeId" : 133146, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3833, "y" : 1961 }, "to" : { "x" : 3856, "y" : 1945 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133149, "reactomeId" : 10358979, "displayName" : "GPR31:12(S)-HETE", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3953, "y" : 1975 }, "minX" : 3891, "maxX" : 4021, "minY" : 1957, "maxY" : 1988, "prop" : { "x" : 3891, "y" : 1963, "width" : 124, "height" : 25 }, "textPosition" : { "x" : 3891, "y" : 1967 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4015, "y" : 1963 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4015, "y" : 1963 } } }, "connectors" : [ { "edgeId" : 133146, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133155, "reactomeId" : 10358905, "displayName" : "SUCNR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1994, "y" : 2228 }, "minX" : 1957, "maxX" : 2044, "minY" : 2211, "maxY" : 2239, "prop" : { "x" : 1957, "y" : 2217, "width" : 75, "height" : 22 }, "textPosition" : { "x" : 1965, "y" : 2217 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2032, "y" : 2217 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2032, "y" : 2217 } } }, "connectors" : [ { "edgeId" : 133154, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2035, "y" : 2236 }, "to" : { "x" : 2044, "y" : 2239 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133152, "reactomeId" : 10358911, "displayName" : "OXGR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1694, "y" : 2230 }, "minX" : 1662, "maxX" : 1732, "minY" : 2213, "maxY" : 2251, "prop" : { "x" : 1662, "y" : 2219, "width" : 64, "height" : 22 }, "textPosition" : { "x" : 1669, "y" : 2219 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1726, "y" : 2219 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1726, "y" : 2219 } } }, "connectors" : [ { "edgeId" : 133150, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1710, "y" : 2244 }, "to" : { "x" : 1726, "y" : 2251 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133153, "reactomeId" : 10358913, "displayName" : "OXGR1:2OG", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1811, "y" : 2233 }, "minX" : 1776, "maxX" : 1853, "minY" : 2210, "maxY" : 2251, "prop" : { "x" : 1776, "y" : 2216, "width" : 71, "height" : 35 }, "textPosition" : { "x" : 1785, "y" : 2216 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1847, "y" : 2216 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1847, "y" : 2216 } } }, "connectors" : [ { "edgeId" : 133150, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133159, "reactomeId" : 10356332, "displayName" : "CCL19", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3665, "y" : 40 }, "minX" : 3634, "maxX" : 3702, "minY" : 24, "maxY" : 60, "prop" : { "x" : 3634, "y" : 30, "width" : 62, "height" : 20 }, "textPosition" : { "x" : 3642, "y" : 30 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3696, "y" : 30 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3696, "y" : 30 } } }, "connectors" : [ { "edgeId" : 133158, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3680, "y" : 53 }, "to" : { "x" : 3695, "y" : 60 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133156, "reactomeId" : 433123, "displayName" : "SUCCA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1991, "y" : 2265 }, "minX" : 1955, "maxX" : 2044, "minY" : 2239, "maxY" : 2280, "prop" : { "x" : 1955, "y" : 2250, "width" : 72, "height" : 30 }, "textPosition" : { "x" : 1966, "y" : 2254 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2022, "y" : 2255 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2022, "y" : 2255 } } }, "connectors" : [ { "edgeId" : 133154, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2021, "y" : 2247 }, "to" : { "x" : 2044, "y" : 2239 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133157, "reactomeId" : 10358907, "displayName" : "SUCNR1:SUCCA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2169, "y" : 2229 }, "minX" : 2111, "maxX" : 2233, "minY" : 2211, "maxY" : 2241, "prop" : { "x" : 2111, "y" : 2217, "width" : 116, "height" : 24 }, "textPosition" : { "x" : 2117, "y" : 2220 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2227, "y" : 2217 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2227, "y" : 2217 } } }, "connectors" : [ { "edgeId" : 133154, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133163, "reactomeId" : 10358959, "displayName" : "PSAP", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 187, "y" : 2300 }, "minX" : 149, "maxX" : 363, "minY" : 2263, "maxY" : 2318, "prop" : { "x" : 149, "y" : 2282, "width" : 76, "height" : 36 }, "textPosition" : { "x" : 167, "y" : 2289 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 225, "y" : 2282 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 225, "y" : 2282 } } }, "connectors" : [ { "edgeId" : 133162, "type" : "INPUT", "segments" : [ { "from" : { "x" : 194, "y" : 2276 }, "to" : { "x" : 202, "y" : 2263 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133207, "type" : "INPUT", "segments" : [ { "from" : { "x" : 231, "y" : 2293 }, "to" : { "x" : 363, "y" : 2272 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133160, "reactomeId" : 10392639, "displayName" : "CCRL2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3675, "y" : 85 }, "minX" : 3652, "maxX" : 3705, "minY" : 60, "maxY" : 96, "prop" : { "x" : 3652, "y" : 74, "width" : 47, "height" : 22 }, "textPosition" : { "x" : 3652, "y" : 74 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3699, "y" : 74 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3699, "y" : 74 } } }, "connectors" : [ { "edgeId" : 133158, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3683, "y" : 71 }, "to" : { "x" : 3695, "y" : 60 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133161, "reactomeId" : 10392641, "displayName" : "CCRL2:CCL19", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3760, "y" : 88 }, "minX" : 3716, "maxX" : 3811, "minY" : 71, "maxY" : 99, "prop" : { "x" : 3716, "y" : 77, "width" : 89, "height" : 22 }, "textPosition" : { "x" : 3716, "y" : 78 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3805, "y" : 77 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3805, "y" : 77 } } }, "connectors" : [ { "edgeId" : 133158, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133167, "reactomeId" : 109276, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1987, "y" : 1879 }, "minX" : 1966, "maxX" : 2059, "minY" : 1863, "maxY" : 1910, "prop" : { "x" : 1966, "y" : 1864, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1970, "y" : 1868 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2004, "y" : 1869 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2004, "y" : 1869 } } }, "connectors" : [ { "edgeId" : 133166, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2012, "y" : 1888 }, "to" : { "x" : 2059, "y" : 1910 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 133164, "reactomeId" : 10358965, "displayName" : "GPR37", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 185, "y" : 2231 }, "minX" : 161, "maxX" : 216, "minY" : 2214, "maxY" : 2263, "prop" : { "x" : 161, "y" : 2220, "width" : 49, "height" : 22 }, "textPosition" : { "x" : 161, "y" : 2220 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 210, "y" : 2220 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 210, "y" : 2220 } } }, "connectors" : [ { "edgeId" : 133162, "type" : "INPUT", "segments" : [ { "from" : { "x" : 190, "y" : 2245 }, "to" : { "x" : 202, "y" : 2263 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133165, "reactomeId" : 10358967, "displayName" : "GPR37:PSAP fragments", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 276, "y" : 2232 }, "minX" : 230, "maxX" : 328, "minY" : 2209, "maxY" : 2250, "prop" : { "x" : 230, "y" : 2215, "width" : 92, "height" : 35 }, "textPosition" : { "x" : 231, "y" : 2215 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 322, "y" : 2215 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 322, "y" : 2215 } } }, "connectors" : [ { "edgeId" : 133162, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133170, "reactomeId" : 10412158, "displayName" : "LPPR4(LPPR1-3,5)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2090, "y" : 1858 }, "minX" : 2032, "maxX" : 2148, "minY" : 1847, "maxY" : 1902, "prop" : { "x" : 2032, "y" : 1847, "width" : 116, "height" : 22 }, "textPosition" : { "x" : 2043, "y" : 1841 }, "connectors" : [ { "edgeId" : 133166, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2089, "y" : 1875 }, "to" : { "x" : 2089, "y" : 1894 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2089, "y" : 1898 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2089, "y" : 1898 } } } ] }, { "id" : 133168, "reactomeId" : 109277, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2186, "y" : 1859 }, "minX" : 2134, "maxX" : 2201, "minY" : 1843, "maxY" : 1910, "prop" : { "x" : 2173, "y" : 1844, "width" : 27, "height" : 30 }, "textPosition" : { "x" : 2177, "y" : 1848 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2195, "y" : 1849 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2195, "y" : 1849 } } }, "connectors" : [ { "edgeId" : 133166, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2170, "y" : 1872 }, "to" : { "x" : 2134, "y" : 1910 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2168, "y" : 1880 }, "b" : { "x" : 2170, "y" : 1872 }, "c" : { "x" : 2162, "y" : 1874 }, "type" : "ARROW", "centre" : { "x" : 2162, "y" : 1874 } } } ] }, { "id" : 133169, "reactomeId" : 6797635, "displayName" : "1,2-DAG", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2198, "y" : 1923 }, "minX" : 2134, "maxX" : 2234, "minY" : 1907, "maxY" : 1938, "prop" : { "x" : 2163, "y" : 1908, "width" : 70, "height" : 30 }, "textPosition" : { "x" : 2169, "y" : 1912 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2228, "y" : 1913 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2228, "y" : 1913 } } }, "connectors" : [ { "edgeId" : 133166, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2160, "y" : 1915 }, "to" : { "x" : 2134, "y" : 1910 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2152, "y" : 1918 }, "b" : { "x" : 2160, "y" : 1915 }, "c" : { "x" : 2154, "y" : 1910 }, "type" : "ARROW", "centre" : { "x" : 2154, "y" : 1910 } } } ] }, { "id" : 133174, "reactomeId" : 10358506, "displayName" : "GPR143:L-Dopa", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1766, "y" : 910 }, "minX" : 1733, "maxX" : 1805, "minY" : 887, "maxY" : 927, "prop" : { "x" : 1733, "y" : 893, "width" : 66, "height" : 34 }, "textPosition" : { "x" : 1735, "y" : 892 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1799, "y" : 893 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1799, "y" : 893 } } }, "connectors" : [ { "edgeId" : 133171, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133172, "reactomeId" : 8851314, "displayName" : "L-Dopa", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1655, "y" : 1009 }, "minX" : 1620, "maxX" : 1712, "minY" : 944, "maxY" : 1024, "prop" : { "x" : 1620, "y" : 994, "width" : 71, "height" : 30 }, "textPosition" : { "x" : 1630, "y" : 998 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1686, "y" : 999 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1686, "y" : 999 } } }, "connectors" : [ { "edgeId" : 133171, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1668, "y" : 991 }, "to" : { "x" : 1712, "y" : 944 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133173, "reactomeId" : 10358504, "displayName" : "GPR143", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1684, "y" : 912 }, "minX" : 1653, "maxX" : 1722, "minY" : 895, "maxY" : 944, "prop" : { "x" : 1653, "y" : 901, "width" : 63, "height" : 22 }, "textPosition" : { "x" : 1656, "y" : 901 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1716, "y" : 901 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1716, "y" : 901 } } }, "connectors" : [ { "edgeId" : 133171, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1693, "y" : 926 }, "to" : { "x" : 1712, "y" : 944 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133178, "reactomeId" : 10358943, "displayName" : "CCR8:CCL1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2598, "y" : 364 }, "minX" : 2558, "maxX" : 2644, "minY" : 347, "maxY" : 375, "prop" : { "x" : 2558, "y" : 353, "width" : 80, "height" : 22 }, "textPosition" : { "x" : 2561, "y" : 354 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2638, "y" : 353 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2638, "y" : 353 } } }, "connectors" : [ { "edgeId" : 133175, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133176, "reactomeId" : 10358941, "displayName" : "CCL1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2506, "y" : 420 }, "minX" : 2484, "maxX" : 2545, "minY" : 402, "maxY" : 431, "prop" : { "x" : 2484, "y" : 409, "width" : 44, "height" : 22 }, "textPosition" : { "x" : 2487, "y" : 409 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2528, "y" : 409 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2528, "y" : 409 } } }, "connectors" : [ { "edgeId" : 133175, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2531, "y" : 409 }, "to" : { "x" : 2545, "y" : 402 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133177, "reactomeId" : 10356350, "displayName" : "CCR8", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2507, "y" : 372 }, "minX" : 2485, "maxX" : 2545, "minY" : 355, "maxY" : 402, "prop" : { "x" : 2485, "y" : 361, "width" : 44, "height" : 22 }, "textPosition" : { "x" : 2487, "y" : 361 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2529, "y" : 361 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2529, "y" : 361 } } }, "connectors" : [ { "edgeId" : 133175, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2520, "y" : 386 }, "to" : { "x" : 2545, "y" : 402 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133182, "reactomeId" : 10358937, "displayName" : "CCL13:CCL2,CCR3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2208, "y" : 370 }, "minX" : 2162, "maxX" : 2260, "minY" : 347, "maxY" : 387, "prop" : { "x" : 2162, "y" : 353, "width" : 92, "height" : 34 }, "textPosition" : { "x" : 2166, "y" : 352 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2254, "y" : 353 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2254, "y" : 353 } } }, "connectors" : [ { "edgeId" : 133179, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133180, "reactomeId" : 10358935, "displayName" : "CCR2,CCR3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2100, "y" : 372 }, "minX" : 2060, "maxX" : 2140, "minY" : 361, "maxY" : 410, "prop" : { "x" : 2060, "y" : 361, "width" : 80, "height" : 22 }, "textPosition" : { "x" : 2062, "y" : 361 }, "connectors" : [ { "edgeId" : 133179, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2110, "y" : 389 }, "to" : { "x" : 2137, "y" : 410 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133181, "reactomeId" : 10358933, "displayName" : "CCL11", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2092, "y" : 430 }, "minX" : 2066, "maxX" : 2137, "minY" : 410, "maxY" : 441, "prop" : { "x" : 2066, "y" : 419, "width" : 53, "height" : 22 }, "textPosition" : { "x" : 2069, "y" : 419 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2119, "y" : 419 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2119, "y" : 419 } } }, "connectors" : [ { "edgeId" : 133179, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2116, "y" : 416 }, "to" : { "x" : 2137, "y" : 410 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133186, "reactomeId" : 10358957, "displayName" : "GPR183:7alpha,25-dihydroxycholesterol", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1817, "y" : 1967 }, "minX" : 1753, "maxX" : 1887, "minY" : 1943, "maxY" : 1985, "prop" : { "x" : 1753, "y" : 1949, "width" : 128, "height" : 36 }, "textPosition" : { "x" : 1753, "y" : 1936 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1881, "y" : 1949 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1881, "y" : 1949 } } }, "connectors" : [ { "edgeId" : 133183, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133184, "reactomeId" : 10358955, "displayName" : "GPR183", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1671, "y" : 1973 }, "minX" : 1643, "maxX" : 1706, "minY" : 1944, "maxY" : 1984, "prop" : { "x" : 1643, "y" : 1962, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 1643, "y" : 1962 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1700, "y" : 1962 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1700, "y" : 1962 } } }, "connectors" : [ { "edgeId" : 133183, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1675, "y" : 1959 }, "to" : { "x" : 1684, "y" : 1944 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133185, "reactomeId" : 8851675, "displayName" : "7alpha,25-dihydroxycholesterol", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1662, "y" : 1913 }, "minX" : 1594, "maxX" : 1731, "minY" : 1890, "maxY" : 1944, "prop" : { "x" : 1594, "y" : 1891, "width" : 136, "height" : 44 }, "textPosition" : { "x" : 1594, "y" : 1895 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1725, "y" : 1896 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1725, "y" : 1896 } } }, "connectors" : [ { "edgeId" : 133183, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1677, "y" : 1938 }, "to" : { "x" : 1684, "y" : 1944 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133190, "reactomeId" : 10416181, "displayName" : "GPR35:Kynurenic acid", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3498, "y" : 2232 }, "minX" : 3442, "maxX" : 3561, "minY" : 2208, "maxY" : 2250, "prop" : { "x" : 3442, "y" : 2214, "width" : 113, "height" : 36 }, "textPosition" : { "x" : 3440, "y" : 2215 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3555, "y" : 2214 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3555, "y" : 2214 } } }, "connectors" : [ { "edgeId" : 133187, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133188, "reactomeId" : 10416179, "displayName" : "GPR35", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3346, "y" : 2232 }, "minX" : 3322, "maxX" : 3387, "minY" : 2215, "maxY" : 2254, "prop" : { "x" : 3322, "y" : 2221, "width" : 49, "height" : 22 }, "textPosition" : { "x" : 3322, "y" : 2221 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3371, "y" : 2221 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3371, "y" : 2221 } } }, "connectors" : [ { "edgeId" : 133187, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3366, "y" : 2246 }, "to" : { "x" : 3387, "y" : 2254 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133189, "reactomeId" : 6805204, "displayName" : "Kynurenic acid", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3346, "y" : 2284 }, "minX" : 3296, "maxX" : 3398, "minY" : 2254, "maxY" : 2299, "prop" : { "x" : 3296, "y" : 2269, "width" : 101, "height" : 30 }, "textPosition" : { "x" : 3297, "y" : 2273 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3392, "y" : 2274 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3392, "y" : 2274 } } }, "connectors" : [ { "edgeId" : 133187, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3366, "y" : 2266 }, "to" : { "x" : 3387, "y" : 2254 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133194, "reactomeId" : 10426134, "displayName" : "NLN", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1698, "y" : 465 }, "minX" : 1678, "maxX" : 1724, "minY" : 448, "maxY" : 501, "prop" : { "x" : 1678, "y" : 454, "width" : 40, "height" : 22 }, "textPosition" : { "x" : 1682, "y" : 454 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1718, "y" : 454 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1718, "y" : 454 } } }, "connectors" : [ { "edgeId" : 133191, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1697, "y" : 479 }, "to" : { "x" : 1697, "y" : 493 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1697, "y" : 497 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1697, "y" : 497 } } } ] }, { "id" : 133192, "reactomeId" : 10426130, "displayName" : "NTS", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1784, "y" : 530 }, "minX" : 1725, "maxX" : 1842, "minY" : 511, "maxY" : 541, "prop" : { "x" : 1733, "y" : 519, "width" : 103, "height" : 22 }, "textPosition" : { "x" : 1768, "y" : 519 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1836, "y" : 519 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1836, "y" : 519 } } }, "connectors" : [ { "edgeId" : 133191, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1749, "y" : 516 }, "to" : { "x" : 1725, "y" : 511 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1741, "y" : 519 }, "b" : { "x" : 1749, "y" : 516 }, "c" : { "x" : 1743, "y" : 511 }, "type" : "ARROW", "centre" : { "x" : 1743, "y" : 511 } } } ] }, { "id" : 133193, "reactomeId" : 10426128, "displayName" : "NTS", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1783, "y" : 478 }, "minX" : 1725, "maxX" : 1842, "minY" : 462, "maxY" : 511, "prop" : { "x" : 1730, "y" : 468, "width" : 106, "height" : 21 }, "textPosition" : { "x" : 1767, "y" : 468 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1836, "y" : 468 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1836, "y" : 468 } } }, "connectors" : [ { "edgeId" : 133191, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1764, "y" : 492 }, "to" : { "x" : 1725, "y" : 511 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1760, "y" : 499 }, "b" : { "x" : 1764, "y" : 492 }, "c" : { "x" : 1756, "y" : 491 }, "type" : "ARROW", "centre" : { "x" : 1756, "y" : 491 } } } ] }, { "id" : 133198, "reactomeId" : 10424243, "displayName" : "ECE1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1063, "y" : 577 }, "minX" : 1044, "maxX" : 1089, "minY" : 517, "maxY" : 588, "prop" : { "x" : 1044, "y" : 566, "width" : 39, "height" : 22 }, "textPosition" : { "x" : 1047, "y" : 560 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1083, "y" : 566 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1083, "y" : 566 } } }, "connectors" : [ { "edgeId" : 133195, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1063, "y" : 563 }, "to" : { "x" : 1064, "y" : 525 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1064, "y" : 521 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1064, "y" : 521 } } } ] }, { "id" : 133196, "reactomeId" : 10424239, "displayName" : "EDN1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1129, "y" : 481 }, "minX" : 1085, "maxX" : 1180, "minY" : 464, "maxY" : 492, "prop" : { "x" : 1085, "y" : 470, "width" : 89, "height" : 22 }, "textPosition" : { "x" : 1108, "y" : 470 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1174, "y" : 470 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1174, "y" : 470 } } }, "connectors" : [ { "edgeId" : 133195, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133197, "reactomeId" : 10358154, "displayName" : "EDN1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1001, "y" : 540 }, "minX" : 980, "maxX" : 1028, "minY" : 523, "maxY" : 551, "prop" : { "x" : 980, "y" : 529, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 980, "y" : 529 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1022, "y" : 529 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1022, "y" : 529 } } }, "connectors" : [ { "edgeId" : 133195, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133202, "reactomeId" : 10424364, "displayName" : "ECE2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 903, "y" : 623 }, "minX" : 884, "maxX" : 929, "minY" : 606, "maxY" : 658, "prop" : { "x" : 884, "y" : 612, "width" : 39, "height" : 22 }, "textPosition" : { "x" : 887, "y" : 606 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 923, "y" : 612 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 923, "y" : 612 } } }, "connectors" : [ { "edgeId" : 133199, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 903, "y" : 637 }, "to" : { "x" : 903, "y" : 650 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 904, "y" : 654 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 904, "y" : 654 } } } ] }, { "id" : 133200, "reactomeId" : 10424358, "displayName" : "EDN1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 840, "y" : 668 }, "minX" : 796, "maxX" : 891, "minY" : 651, "maxY" : 679, "prop" : { "x" : 796, "y" : 657, "width" : 89, "height" : 22 }, "textPosition" : { "x" : 819, "y" : 657 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 885, "y" : 657 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 885, "y" : 657 } } }, "connectors" : [ { "edgeId" : 133199, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133201, "reactomeId" : 10424360, "displayName" : "EDN1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 962, "y" : 666 }, "minX" : 941, "maxX" : 989, "minY" : 649, "maxY" : 677, "prop" : { "x" : 941, "y" : 655, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 941, "y" : 655 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 983, "y" : 655 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 983, "y" : 655 } } }, "connectors" : [ { "edgeId" : 133199, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133206, "reactomeId" : 10421818, "displayName" : "Resolvin E1:CMKLR1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3779, "y" : 2234 }, "minX" : 3738, "maxX" : 3827, "minY" : 2211, "maxY" : 2251, "prop" : { "x" : 3738, "y" : 2217, "width" : 83, "height" : 34 }, "textPosition" : { "x" : 3738, "y" : 2216 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3821, "y" : 2217 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3821, "y" : 2217 } } }, "connectors" : [ { "edgeId" : 133203, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133204, "reactomeId" : 9023982, "displayName" : "18(S)-RvE1, 18(R)-RvE1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3599, "y" : 2291 }, "minX" : 3560, "maxX" : 3642, "minY" : 2248, "maxY" : 2309, "prop" : { "x" : 3560, "y" : 2273, "width" : 78, "height" : 36 }, "textPosition" : { "x" : 3568, "y" : 2267 }, "connectors" : [ { "edgeId" : 133203, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3617, "y" : 2267 }, "to" : { "x" : 3642, "y" : 2248 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133205, "reactomeId" : 10421816, "displayName" : "CMLKR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3598, "y" : 2230 }, "minX" : 3570, "maxX" : 3642, "minY" : 2213, "maxY" : 2248, "prop" : { "x" : 3570, "y" : 2219, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 3571, "y" : 2219 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3627, "y" : 2219 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3627, "y" : 2219 } } }, "connectors" : [ { "edgeId" : 133203, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3624, "y" : 2244 }, "to" : { "x" : 3642, "y" : 2248 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133211, "reactomeId" : 9609307, "displayName" : "β-blockers", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 4278, "y" : 1404 }, "minX" : 4161, "maxX" : 4317, "minY" : 1392, "maxY" : 1416, "prop" : { "x" : 4239, "y" : 1392, "width" : 78, "height" : 24 }, "textPosition" : { "x" : 4241, "y" : 1393 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133210, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4233, "y" : 1403 }, "to" : { "x" : 4161, "y" : 1403 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133208, "reactomeId" : 10358971, "displayName" : "GPR37L1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 368, "y" : 2237 }, "minX" : 334, "maxX" : 408, "minY" : 2219, "maxY" : 2272, "prop" : { "x" : 334, "y" : 2225, "width" : 68, "height" : 24 }, "textPosition" : { "x" : 336, "y" : 2226 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 402, "y" : 2225 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 402, "y" : 2225 } } }, "connectors" : [ { "edgeId" : 133207, "type" : "INPUT", "segments" : [ { "from" : { "x" : 366, "y" : 2252 }, "to" : { "x" : 363, "y" : 2272 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133209, "reactomeId" : 10358973, "displayName" : "GPR37L1:Prosaposin fragments", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 489, "y" : 2235 }, "minX" : 422, "maxX" : 562, "minY" : 2211, "maxY" : 2253, "prop" : { "x" : 422, "y" : 2217, "width" : 134, "height" : 36 }, "textPosition" : { "x" : 448, "y" : 2204 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 556, "y" : 2217 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 556, "y" : 2217 } } }, "connectors" : [ { "edgeId" : 133207, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133214, "reactomeId" : 9615246, "displayName" : "ARBs", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 294, "y" : 46 }, "minX" : 275, "maxX" : 343, "minY" : 35, "maxY" : 57, "prop" : { "x" : 275, "y" : 35, "width" : 38, "height" : 22 }, "textPosition" : { "x" : 278, "y" : 29 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133213, "type" : "INPUT", "segments" : [ { "from" : { "x" : 319, "y" : 48 }, "to" : { "x" : 343, "y" : 52 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133212, "reactomeId" : 10360923, "displayName" : "ADRB1,2,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 4019, "y" : 1404 }, "minX" : 3982, "maxX" : 4161, "minY" : 1392, "maxY" : 1416, "prop" : { "x" : 3982, "y" : 1392, "width" : 74, "height" : 24 }, "textPosition" : { "x" : 3982, "y" : 1393 }, "connectors" : [ { "edgeId" : 133210, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4062, "y" : 1403 }, "to" : { "x" : 4161, "y" : 1403 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133219, "reactomeId" : 10360927, "displayName" : "ADRB1,2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 4042, "y" : 1516 }, "minX" : 4012, "maxX" : 4097, "minY" : 1505, "maxY" : 1527, "prop" : { "x" : 4012, "y" : 1505, "width" : 61, "height" : 22 }, "textPosition" : { "x" : 4012, "y" : 1505 }, "connectors" : [ { "edgeId" : 133218, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4079, "y" : 1516 }, "to" : { "x" : 4097, "y" : 1517 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133216, "reactomeId" : 10358571, "displayName" : "AGTR2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 707, "y" : 86 }, "minX" : 639, "maxX" : 741, "minY" : 44, "maxY" : 97, "prop" : { "x" : 680, "y" : 75, "width" : 55, "height" : 22 }, "textPosition" : { "x" : 683, "y" : 75 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 735, "y" : 75 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 735, "y" : 75 } } }, "connectors" : [ { "edgeId" : 133215, "type" : "INPUT", "segments" : [ { "from" : { "x" : 689, "y" : 72 }, "to" : { "x" : 639, "y" : 44 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133217, "reactomeId" : 10358573, "displayName" : "AGTR2:AGT(25-32)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 621, "y" : 83 }, "minX" : 581, "maxX" : 667, "minY" : 59, "maxY" : 101, "prop" : { "x" : 581, "y" : 65, "width" : 80, "height" : 36 }, "textPosition" : { "x" : 583, "y" : 66 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 661, "y" : 65 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 661, "y" : 65 } } }, "connectors" : [ { "edgeId" : 133215, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133222, "reactomeId" : 10357506, "displayName" : "ADRB2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 4040, "y" : 1609 }, "minX" : 4016, "maxX" : 4182, "minY" : 1550, "maxY" : 1620, "prop" : { "x" : 4016, "y" : 1598, "width" : 49, "height" : 22 }, "textPosition" : { "x" : 4016, "y" : 1598 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4065, "y" : 1598 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4065, "y" : 1598 } } }, "connectors" : [ { "edgeId" : 133221, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4068, "y" : 1598 }, "to" : { "x" : 4182, "y" : 1550 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133223, "reactomeId" : 10357508, "displayName" : "ADRB2:ADR,NAd", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4035, "y" : 1568 }, "minX" : 3999, "maxX" : 4077, "minY" : 1546, "maxY" : 1585, "prop" : { "x" : 3999, "y" : 1552, "width" : 72, "height" : 33 }, "textPosition" : { "x" : 4004, "y" : 1550 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4071, "y" : 1552 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4071, "y" : 1552 } } }, "connectors" : [ { "edgeId" : 133221, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133220, "reactomeId" : 9611691, "displayName" : "β1,2-agonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 4272, "y" : 1518 }, "minX" : 4097, "maxX" : 4302, "minY" : 1501, "maxY" : 1535, "prop" : { "x" : 4243, "y" : 1501, "width" : 59, "height" : 34 }, "textPosition" : { "x" : 4245, "y" : 1494 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133218, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4237, "y" : 1517 }, "to" : { "x" : 4097, "y" : 1517 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133226, "reactomeId" : 10357514, "displayName" : "ADRB3:ADR,NAd", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4034, "y" : 1167 }, "minX" : 4000, "maxX" : 4075, "minY" : 1145, "maxY" : 1183, "prop" : { "x" : 4000, "y" : 1151, "width" : 69, "height" : 32 }, "textPosition" : { "x" : 4003, "y" : 1148 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4069, "y" : 1151 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4069, "y" : 1151 } } }, "connectors" : [ { "edgeId" : 133224, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133227, "reactomeId" : 10432074, "displayName" : "β3-agonists:ADBR3", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 3935, "y" : 1122 }, "minX" : 3894, "maxX" : 4140, "minY" : 1098, "maxY" : 1154, "prop" : { "x" : 3894, "y" : 1104, "width" : 82, "height" : 36 }, "textPosition" : { "x" : 3902, "y" : 1091 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3976, "y" : 1104 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3976, "y" : 1104 } } }, "connectors" : [ { "edgeId" : 133224, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 3979, "y" : 1127 }, "to" : { "x" : 4140, "y" : 1151 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 4133, "y" : 1154 }, "b" : { "x" : 4140, "y" : 1151 }, "c" : { "x" : 4134, "y" : 1146 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 4134, "y" : 1146 } } }, { "edgeId" : 133228, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133225, "reactomeId" : 10357512, "displayName" : "ADRB3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 4038, "y" : 1118 }, "minX" : 3998, "maxX" : 4149, "minY" : 1068, "maxY" : 1150, "prop" : { "x" : 4014, "y" : 1107, "width" : 49, "height" : 22 }, "textPosition" : { "x" : 4014, "y" : 1107 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4063, "y" : 1107 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4063, "y" : 1107 } } }, "connectors" : [ { "edgeId" : 133224, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4066, "y" : 1125 }, "to" : { "x" : 4149, "y" : 1150 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133228, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4029, "y" : 1104 }, "to" : { "x" : 3998, "y" : 1068 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133231, "reactomeId" : 9611687, "displayName" : "β1-agonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 4273, "y" : 1218 }, "minX" : 4130, "maxX" : 4315, "minY" : 1206, "maxY" : 1231, "prop" : { "x" : 4231, "y" : 1206, "width" : 84, "height" : 25 }, "textPosition" : { "x" : 4232, "y" : 1208 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133230, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4225, "y" : 1218 }, "to" : { "x" : 4130, "y" : 1220 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133229, "reactomeId" : 9611836, "displayName" : "β3-agonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 3990, "y" : 1035 }, "minX" : 3951, "maxX" : 4029, "minY" : 1024, "maxY" : 1068, "prop" : { "x" : 3951, "y" : 1024, "width" : 78, "height" : 22 }, "textPosition" : { "x" : 3959, "y" : 1018 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133228, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3992, "y" : 1052 }, "to" : { "x" : 3998, "y" : 1068 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133235, "reactomeId" : 9617394, "displayName" : "α1-antagonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 1859, "y" : 1016 }, "minX" : 1811, "maxX" : 1908, "minY" : 964, "maxY" : 1027, "prop" : { "x" : 1811, "y" : 1005, "width" : 97, "height" : 22 }, "textPosition" : { "x" : 1818, "y" : 999 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133234, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1858, "y" : 999 }, "to" : { "x" : 1858, "y" : 964 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133233, "reactomeId" : 9611319, "displayName" : "P2RY12 antagonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 928, "y" : 1668 }, "minX" : 890, "maxX" : 1007, "minY" : 1652, "maxY" : 1684, "prop" : { "x" : 890, "y" : 1652, "width" : 76, "height" : 32 }, "textPosition" : { "x" : 890, "y" : 1644 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133232, "type" : "INPUT", "segments" : [ { "from" : { "x" : 972, "y" : 1668 }, "to" : { "x" : 1007, "y" : 1668 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133239, "reactomeId" : 9626909, "displayName" : "α2-agonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 2698, "y" : 1010 }, "minX" : 2583, "maxX" : 2746, "minY" : 999, "maxY" : 1021, "prop" : { "x" : 2651, "y" : 999, "width" : 95, "height" : 22 }, "textPosition" : { "x" : 2657, "y" : 999 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133238, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2645, "y" : 1010 }, "to" : { "x" : 2583, "y" : 1010 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133237, "reactomeId" : 9623382, "displayName" : "α1-agonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 1972, "y" : 1014 }, "minX" : 1933, "maxX" : 2012, "minY" : 950, "maxY" : 1025, "prop" : { "x" : 1933, "y" : 1003, "width" : 79, "height" : 22 }, "textPosition" : { "x" : 1941, "y" : 997 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133236, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1971, "y" : 997 }, "to" : { "x" : 1971, "y" : 950 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133242, "reactomeId" : 9653947, "displayName" : "DRD2 antagonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 84, "y" : 1229 }, "minX" : 43, "maxX" : 148, "minY" : 1210, "maxY" : 1248, "prop" : { "x" : 43, "y" : 1210, "width" : 83, "height" : 38 }, "textPosition" : { "x" : 43, "y" : 1211 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133241, "type" : "INPUT", "segments" : [ { "from" : { "x" : 132, "y" : 1240 }, "to" : { "x" : 148, "y" : 1246 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133243, "reactomeId" : 10433440, "displayName" : "DRD2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 149, "y" : 1185 }, "minX" : 128, "maxX" : 235, "minY" : 1117, "maxY" : 1246, "prop" : { "x" : 128, "y" : 1174, "width" : 43, "height" : 22 }, "textPosition" : { "x" : 128, "y" : 1174 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 171, "y" : 1174 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 171, "y" : 1174 } } }, "connectors" : [ { "edgeId" : 133241, "type" : "INPUT", "segments" : [ { "from" : { "x" : 148, "y" : 1199 }, "to" : { "x" : 148, "y" : 1246 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133245, "type" : "INPUT", "segments" : [ { "from" : { "x" : 162, "y" : 1171 }, "to" : { "x" : 235, "y" : 1117 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133240, "reactomeId" : 10432424, "displayName" : "α2-agonists:ADRA2A,B,C", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 2623, "y" : 917 }, "minX" : 2575, "maxX" : 2677, "minY" : 893, "maxY" : 935, "prop" : { "x" : 2575, "y" : 899, "width" : 96, "height" : 36 }, "textPosition" : { "x" : 2579, "y" : 900 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2671, "y" : 899 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2671, "y" : 899 } } }, "connectors" : [ { "edgeId" : 133238, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133246, "reactomeId" : 10433488, "displayName" : "DRD2:DA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 166, "y" : 1117 }, "minX" : 132, "maxX" : 206, "minY" : 1100, "maxY" : 1129, "prop" : { "x" : 132, "y" : 1106, "width" : 68, "height" : 23 }, "textPosition" : { "x" : 134, "y" : 1108 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 200, "y" : 1106 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 200, "y" : 1106 } } }, "connectors" : [ { "edgeId" : 133245, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133244, "reactomeId" : 10433442, "displayName" : "DRD2:DRD2 antagonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 147, "y" : 1316 }, "minX" : 101, "maxX" : 200, "minY" : 1291, "maxY" : 1335, "prop" : { "x" : 101, "y" : 1297, "width" : 93, "height" : 38 }, "textPosition" : { "x" : 105, "y" : 1300 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 194, "y" : 1297 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 194, "y" : 1297 } } }, "connectors" : [ { "edgeId" : 133241, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133251, "reactomeId" : 10433687, "displayName" : "AVPR2:desmopressin", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 172, "y" : 2654 }, "minX" : 127, "maxX" : 223, "minY" : 2630, "maxY" : 2672, "prop" : { "x" : 127, "y" : 2636, "width" : 90, "height" : 36 }, "textPosition" : { "x" : 128, "y" : 2623 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 217, "y" : 2636 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 217, "y" : 2636 } } }, "connectors" : [ { "edgeId" : 133250, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133248, "reactomeId" : 9667393, "displayName" : "desmopressin", "schemaClass" : "ProteinDrug", "renderableClass" : "ProteinDrug", "position" : { "x" : 46, "y" : 2615 }, "minX" : 0, "maxX" : 118, "minY" : 2478, "maxY" : 2680, "prop" : { "x" : 0, "y" : 2602, "width" : 93, "height" : 26 }, "textPosition" : { "x" : 2, "y" : 2598 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 255, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 133247, "type" : "INPUT", "segments" : [ { "from" : { "x" : 42, "y" : 2599 }, "to" : { "x" : 11, "y" : 2500 } }, { "from" : { "x" : 11, "y" : 2500 }, "to" : { "x" : 118, "y" : 2478 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133250, "type" : "INPUT", "segments" : [ { "from" : { "x" : 49, "y" : 2631 }, "to" : { "x" : 63, "y" : 2680 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133249, "reactomeId" : 10433683, "displayName" : "AVPR1A,1B:desmopressin", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 266, "y" : 2479 }, "minX" : 221, "maxX" : 318, "minY" : 2455, "maxY" : 2497, "prop" : { "x" : 221, "y" : 2461, "width" : 91, "height" : 36 }, "textPosition" : { "x" : 222, "y" : 2448 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 312, "y" : 2461 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 312, "y" : 2461 } } }, "connectors" : [ { "edgeId" : 133247, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133254, "reactomeId" : 10433691, "displayName" : "AVPR1A,2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 378, "y" : 2480 }, "minX" : 344, "maxX" : 447, "minY" : 2469, "maxY" : 2491, "prop" : { "x" : 344, "y" : 2469, "width" : 68, "height" : 22 }, "textPosition" : { "x" : 344, "y" : 2469 }, "connectors" : [ { "edgeId" : 133252, "type" : "INPUT", "segments" : [ { "from" : { "x" : 418, "y" : 2479 }, "to" : { "x" : 447, "y" : 2479 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133255, "reactomeId" : 10433693, "displayName" : "AVPR1A,2:AVPR antagonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 538, "y" : 2481 }, "minX" : 485, "maxX" : 598, "minY" : 2457, "maxY" : 2499, "prop" : { "x" : 485, "y" : 2463, "width" : 107, "height" : 36 }, "textPosition" : { "x" : 485, "y" : 2464 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 592, "y" : 2463 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 592, "y" : 2463 } } }, "connectors" : [ { "edgeId" : 133252, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133253, "reactomeId" : 9667595, "displayName" : "AVPR antagonists", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 415, "y" : 2403 }, "minX" : 361, "maxX" : 470, "minY" : 2392, "maxY" : 2479, "prop" : { "x" : 361, "y" : 2392, "width" : 109, "height" : 22 }, "textPosition" : { "x" : 374, "y" : 2386 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133252, "type" : "INPUT", "segments" : [ { "from" : { "x" : 419, "y" : 2420 }, "to" : { "x" : 447, "y" : 2479 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133258, "reactomeId" : 9667607, "displayName" : "atosiban", "schemaClass" : "ProteinDrug", "renderableClass" : "ProteinDrug", "position" : { "x" : 693, "y" : 2404 }, "minX" : 661, "maxX" : 725, "minY" : 2392, "maxY" : 2445, "prop" : { "x" : 661, "y" : 2392, "width" : 64, "height" : 24 }, "textPosition" : { "x" : 661, "y" : 2393 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 255, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 133256, "type" : "INPUT", "segments" : [ { "from" : { "x" : 702, "y" : 2419 }, "to" : { "x" : 724, "y" : 2445 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133259, "reactomeId" : 10433699, "displayName" : "AVPR1A,B,2:atosiban", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 649, "y" : 2480 }, "minX" : 608, "maxX" : 697, "minY" : 2456, "maxY" : 2498, "prop" : { "x" : 608, "y" : 2462, "width" : 83, "height" : 36 }, "textPosition" : { "x" : 612, "y" : 2463 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 691, "y" : 2462 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 691, "y" : 2462 } } }, "connectors" : [ { "edgeId" : 133256, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133257, "reactomeId" : 10433697, "displayName" : "AVPR1A,B, 2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 773, "y" : 2483 }, "minX" : 724, "maxX" : 815, "minY" : 2445, "maxY" : 2494, "prop" : { "x" : 732, "y" : 2472, "width" : 83, "height" : 22 }, "textPosition" : { "x" : 735, "y" : 2466 }, "connectors" : [ { "edgeId" : 133256, "type" : "INPUT", "segments" : [ { "from" : { "x" : 758, "y" : 2466 }, "to" : { "x" : 724, "y" : 2445 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133262, "reactomeId" : 10358128, "displayName" : "CYSLTR1:LTC4,LTD4,LTE4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1128, "y" : 2481 }, "minX" : 1079, "maxX" : 1183, "minY" : 2457, "maxY" : 2499, "prop" : { "x" : 1079, "y" : 2463, "width" : 98, "height" : 36 }, "textPosition" : { "x" : 1079, "y" : 2464 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1177, "y" : 2463 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1177, "y" : 2463 } } }, "connectors" : [ { "edgeId" : 133260, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133263, "reactomeId" : 10434015, "displayName" : "CYSLTR1:CYSLTR1 antagonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 1405, "y" : 2480 }, "minX" : 1204, "maxX" : 1471, "minY" : 2456, "maxY" : 2520, "prop" : { "x" : 1346, "y" : 2462, "width" : 119, "height" : 36 }, "textPosition" : { "x" : 1346, "y" : 2463 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1465, "y" : 2462 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1465, "y" : 2462 } } }, "connectors" : [ { "edgeId" : 133260, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1343, "y" : 2493 }, "to" : { "x" : 1226, "y" : 2520 } }, { "from" : { "x" : 1226, "y" : 2520 }, "to" : { "x" : 1207, "y" : 2488 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1204, "y" : 2490 }, "b" : { "x" : 1210, "y" : 2486 }, "c" : { "x" : 1207, "y" : 2488 }, "type" : "STOP", "centre" : { "x" : 1207, "y" : 2488 } } }, { "edgeId" : 133264, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133261, "reactomeId" : 10358126, "displayName" : "CYSLTR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1296, "y" : 2481 }, "minX" : 1226, "maxX" : 1366, "minY" : 2438, "maxY" : 2492, "prop" : { "x" : 1266, "y" : 2470, "width" : 60, "height" : 22 }, "textPosition" : { "x" : 1266, "y" : 2470 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1326, "y" : 2470 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1326, "y" : 2470 } } }, "connectors" : [ { "edgeId" : 133260, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1263, "y" : 2480 }, "to" : { "x" : 1226, "y" : 2480 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133264, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1313, "y" : 2467 }, "to" : { "x" : 1366, "y" : 2438 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133267, "reactomeId" : 10433952, "displayName" : "S1PR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3015, "y" : 2703 }, "minX" : 2968, "maxX" : 3095, "minY" : 2686, "maxY" : 2756, "prop" : { "x" : 2992, "y" : 2692, "width" : 46, "height" : 22 }, "textPosition" : { "x" : 2995, "y" : 2686 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3038, "y" : 2692 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3038, "y" : 2692 } } }, "connectors" : [ { "edgeId" : 133266, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3003, "y" : 2717 }, "to" : { "x" : 2968, "y" : 2749 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133271, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3031, "y" : 2717 }, "to" : { "x" : 3095, "y" : 2756 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133265, "reactomeId" : 9684615, "displayName" : "CYSLTR1 antagonists", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 1367, "y" : 2372 }, "minX" : 1303, "maxX" : 1432, "minY" : 2361, "maxY" : 2438, "prop" : { "x" : 1303, "y" : 2361, "width" : 129, "height" : 22 }, "textPosition" : { "x" : 1326, "y" : 2355 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133264, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1366, "y" : 2389 }, "to" : { "x" : 1366, "y" : 2438 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133270, "reactomeId" : 10433954, "displayName" : "S1PR1:S1PR1 agonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 3096, "y" : 2704 }, "minX" : 2951, "maxX" : 3148, "minY" : 2665, "maxY" : 2723, "prop" : { "x" : 3051, "y" : 2686, "width" : 91, "height" : 36 }, "textPosition" : { "x" : 3065, "y" : 2673 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3142, "y" : 2686 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3142, "y" : 2686 } } }, "connectors" : [ { "edgeId" : 133266, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 3048, "y" : 2688 }, "to" : { "x" : 2983, "y" : 2665 } }, { "from" : { "x" : 2983, "y" : 2665 }, "to" : { "x" : 2951, "y" : 2723 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2951, "y" : 2715 }, "b" : { "x" : 2951, "y" : 2723 }, "c" : { "x" : 2958, "y" : 2719 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2958, "y" : 2719 } } }, { "edgeId" : 133271, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133268, "reactomeId" : 419305, "displayName" : "C18-S1P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2968, "y" : 2795 }, "minX" : 2945, "maxX" : 2993, "minY" : 2749, "maxY" : 2807, "prop" : { "x" : 2945, "y" : 2783, "width" : 47, "height" : 24 }, "textPosition" : { "x" : 2950, "y" : 2778 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2987, "y" : 2788 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2987, "y" : 2788 } } }, "connectors" : [ { "edgeId" : 133266, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2968, "y" : 2780 }, "to" : { "x" : 2968, "y" : 2749 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133269, "reactomeId" : 10434135, "displayName" : "S1PR1:S1P", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2916, "y" : 2700 }, "minX" : 2881, "maxX" : 2958, "minY" : 2683, "maxY" : 2711, "prop" : { "x" : 2881, "y" : 2689, "width" : 71, "height" : 22 }, "textPosition" : { "x" : 2890, "y" : 2676 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2952, "y" : 2689 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2952, "y" : 2689 } } }, "connectors" : [ { "edgeId" : 133266, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133274, "reactomeId" : 9692737, "displayName" : "HRH2 antagonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 689, "y" : 2777 }, "minX" : 631, "maxX" : 748, "minY" : 2739, "maxY" : 2788, "prop" : { "x" : 631, "y" : 2766, "width" : 117, "height" : 22 }, "textPosition" : { "x" : 648, "y" : 2760 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133273, "type" : "INPUT", "segments" : [ { "from" : { "x" : 688, "y" : 2760 }, "to" : { "x" : 688, "y" : 2739 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133275, "reactomeId" : 10434164, "displayName" : "HRH2:HRH2 antagonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 756, "y" : 2704 }, "minX" : 707, "maxX" : 812, "minY" : 2680, "maxY" : 2723, "prop" : { "x" : 707, "y" : 2686, "width" : 99, "height" : 37 }, "textPosition" : { "x" : 714, "y" : 2688 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 806, "y" : 2686 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 806, "y" : 2686 } } }, "connectors" : [ { "edgeId" : 133273, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133272, "reactomeId" : 9678899, "displayName" : "S1PR1 agonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 3096, "y" : 2804 }, "minX" : 3058, "maxX" : 3134, "minY" : 2756, "maxY" : 2821, "prop" : { "x" : 3058, "y" : 2788, "width" : 76, "height" : 33 }, "textPosition" : { "x" : 3065, "y" : 2787 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133271, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3095, "y" : 2782 }, "to" : { "x" : 3095, "y" : 2756 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133278, "reactomeId" : 10434186, "displayName" : "HRH3:Hist", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2586, "y" : 2698 }, "minX" : 2548, "maxX" : 2631, "minY" : 2682, "maxY" : 2709, "prop" : { "x" : 2548, "y" : 2688, "width" : 77, "height" : 21 }, "textPosition" : { "x" : 2551, "y" : 2688 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2625, "y" : 2688 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2625, "y" : 2688 } } }, "connectors" : [ { "edgeId" : 133276, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133277, "reactomeId" : 10434180, "displayName" : "HRH3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2497, "y" : 2700 }, "minX" : 2469, "maxX" : 2576, "minY" : 2683, "maxY" : 2757, "prop" : { "x" : 2472, "y" : 2689, "width" : 50, "height" : 22 }, "textPosition" : { "x" : 2476, "y" : 2689 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2522, "y" : 2689 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2522, "y" : 2689 } } }, "connectors" : [ { "edgeId" : 133279, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2490, "y" : 2714 }, "to" : { "x" : 2469, "y" : 2747 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133276, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2512, "y" : 2714 }, "to" : { "x" : 2576, "y" : 2757 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133283, "reactomeId" : 10433336, "displayName" : "HTR1A", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2685, "y" : 2479 }, "minX" : 2607, "maxX" : 2833, "minY" : 2415, "maxY" : 2490, "prop" : { "x" : 2660, "y" : 2468, "width" : 50, "height" : 22 }, "textPosition" : { "x" : 2661, "y" : 2468 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2710, "y" : 2468 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2710, "y" : 2468 } } }, "connectors" : [ { "edgeId" : 133282, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2657, "y" : 2479 }, "to" : { "x" : 2607, "y" : 2479 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133286, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2713, "y" : 2469 }, "to" : { "x" : 2833, "y" : 2423 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133289, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2688, "y" : 2465 }, "to" : { "x" : 2707, "y" : 2415 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133280, "reactomeId" : 9692536, "displayName" : "pitolisant", "schemaClass" : "ChemicalDrug", "renderableClass" : "ChemicalDrug", "position" : { "x" : 2469, "y" : 2791 }, "minX" : 2428, "maxX" : 2511, "minY" : 2747, "maxY" : 2806, "prop" : { "x" : 2428, "y" : 2776, "width" : 83, "height" : 30 }, "textPosition" : { "x" : 2436, "y" : 2780 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133279, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2469, "y" : 2773 }, "to" : { "x" : 2469, "y" : 2747 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133281, "reactomeId" : 10434182, "displayName" : "HRH3:pitosilant", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 2411, "y" : 2703 }, "minX" : 2367, "maxX" : 2461, "minY" : 2681, "maxY" : 2720, "prop" : { "x" : 2367, "y" : 2687, "width" : 88, "height" : 33 }, "textPosition" : { "x" : 2378, "y" : 2685 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2455, "y" : 2687 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2455, "y" : 2687 } } }, "connectors" : [ { "edgeId" : 133279, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133287, "reactomeId" : 9648224, "displayName" : "HTR1A antagonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 2833, "y" : 2386 }, "minX" : 2768, "maxX" : 2899, "minY" : 2373, "maxY" : 2423, "prop" : { "x" : 2768, "y" : 2373, "width" : 131, "height" : 26 }, "textPosition" : { "x" : 2770, "y" : 2375 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133286, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2833, "y" : 2405 }, "to" : { "x" : 2833, "y" : 2423 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133284, "reactomeId" : 114523, "displayName" : "5HT", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2608, "y" : 2430 }, "minX" : 2586, "maxX" : 2632, "minY" : 2413, "maxY" : 2479, "prop" : { "x" : 2586, "y" : 2414, "width" : 45, "height" : 32 }, "textPosition" : { "x" : 2592, "y" : 2419 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2626, "y" : 2419 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2626, "y" : 2419 } } }, "connectors" : [ { "edgeId" : 133282, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2607, "y" : 2449 }, "to" : { "x" : 2607, "y" : 2479 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133285, "reactomeId" : 10434246, "displayName" : "HTR1A:5HT", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2535, "y" : 2480 }, "minX" : 2496, "maxX" : 2581, "minY" : 2463, "maxY" : 2491, "prop" : { "x" : 2496, "y" : 2469, "width" : 79, "height" : 22 }, "textPosition" : { "x" : 2497, "y" : 2470 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2575, "y" : 2469 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2575, "y" : 2469 } } }, "connectors" : [ { "edgeId" : 133282, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133290, "reactomeId" : 9693410, "displayName" : "HTR1A agonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 2708, "y" : 2356 }, "minX" : 2653, "maxX" : 2764, "minY" : 2345, "maxY" : 2415, "prop" : { "x" : 2653, "y" : 2345, "width" : 111, "height" : 22 }, "textPosition" : { "x" : 2655, "y" : 2345 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133289, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2707, "y" : 2373 }, "to" : { "x" : 2707, "y" : 2415 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133291, "reactomeId" : 10434250, "displayName" : "HTR1A:HTR1A agonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 2807, "y" : 2480 }, "minX" : 2758, "maxX" : 2863, "minY" : 2456, "maxY" : 2498, "prop" : { "x" : 2758, "y" : 2462, "width" : 99, "height" : 36 }, "textPosition" : { "x" : 2759, "y" : 2463 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2857, "y" : 2462 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2857, "y" : 2462 } } }, "connectors" : [ { "edgeId" : 133289, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133288, "reactomeId" : 10433338, "displayName" : "HTR1A:HTR1A Antagonist drugs", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 2957, "y" : 2478 }, "minX" : 2896, "maxX" : 3024, "minY" : 2454, "maxY" : 2496, "prop" : { "x" : 2896, "y" : 2460, "width" : 122, "height" : 36 }, "textPosition" : { "x" : 2899, "y" : 2461 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3018, "y" : 2460 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3018, "y" : 2460 } } }, "connectors" : [ { "edgeId" : 133286, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133294, "reactomeId" : 10434389, "displayName" : "CNRs:CNR agonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 3115, "y" : 2474 }, "minX" : 3072, "maxX" : 3165, "minY" : 2451, "maxY" : 2492, "prop" : { "x" : 3072, "y" : 2457, "width" : 87, "height" : 35 }, "textPosition" : { "x" : 3079, "y" : 2457 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3159, "y" : 2457 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3159, "y" : 2457 } } }, "connectors" : [ { "edgeId" : 133292, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133293, "reactomeId" : 9696324, "displayName" : "CNR agonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 3146, "y" : 2357 }, "minX" : 3100, "maxX" : 3193, "minY" : 2344, "maxY" : 2408, "prop" : { "x" : 3100, "y" : 2344, "width" : 93, "height" : 26 }, "textPosition" : { "x" : 3101, "y" : 2346 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133292, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3146, "y" : 2376 }, "to" : { "x" : 3146, "y" : 2408 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133299, "reactomeId" : 9704261, "displayName" : "CHRM2 antagonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 3483, "y" : 2793 }, "minX" : 3423, "maxX" : 3544, "minY" : 2747, "maxY" : 2804, "prop" : { "x" : 3423, "y" : 2782, "width" : 121, "height" : 22 }, "textPosition" : { "x" : 3442, "y" : 2776 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133298, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3483, "y" : 2776 }, "to" : { "x" : 3483, "y" : 2747 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133296, "reactomeId" : 9704291, "displayName" : "CHRM1,3,5 antagonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 1110, "y" : 2826 }, "minX" : 1070, "maxX" : 1150, "minY" : 2763, "maxY" : 2844, "prop" : { "x" : 1070, "y" : 2808, "width" : 80, "height" : 36 }, "textPosition" : { "x" : 1070, "y" : 2802 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133295, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1109, "y" : 2802 }, "to" : { "x" : 1109, "y" : 2763 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133297, "reactomeId" : 10434565, "displayName" : "CHRM1,3,5:CHRM1,3,5 antagonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 1167, "y" : 2704 }, "minX" : 1101, "maxX" : 1239, "minY" : 2678, "maxY" : 2724, "prop" : { "x" : 1101, "y" : 2684, "width" : 132, "height" : 40 }, "textPosition" : { "x" : 1104, "y" : 2689 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1233, "y" : 2684 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1233, "y" : 2684 } } }, "connectors" : [ { "edgeId" : 133295, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133303, "reactomeId" : 9718005, "displayName" : "PTGFR agonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 1575, "y" : 2362 }, "minX" : 1526, "maxX" : 1624, "minY" : 2351, "maxY" : 2409, "prop" : { "x" : 1526, "y" : 2351, "width" : 98, "height" : 22 }, "textPosition" : { "x" : 1544, "y" : 2345 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133302, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1577, "y" : 2379 }, "to" : { "x" : 1585, "y" : 2409 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133300, "reactomeId" : 10358639, "displayName" : "CHRM2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3446, "y" : 2702 }, "minX" : 3420, "maxX" : 3483, "minY" : 2685, "maxY" : 2747, "prop" : { "x" : 3420, "y" : 2691, "width" : 52, "height" : 22 }, "textPosition" : { "x" : 3420, "y" : 2691 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3472, "y" : 2691 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3472, "y" : 2691 } } }, "connectors" : [ { "edgeId" : 133298, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3455, "y" : 2716 }, "to" : { "x" : 3483, "y" : 2747 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133301, "reactomeId" : 10434569, "displayName" : "CHRM2:CHRM2 antagonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 3545, "y" : 2705 }, "minX" : 3494, "maxX" : 3603, "minY" : 2681, "maxY" : 2723, "prop" : { "x" : 3494, "y" : 2687, "width" : 103, "height" : 36 }, "textPosition" : { "x" : 3494, "y" : 2688 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3597, "y" : 2687 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3597, "y" : 2687 } } }, "connectors" : [ { "edgeId" : 133298, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133306, "reactomeId" : 9718390, "displayName" : "GNRHR peptide agonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 1640, "y" : 2813 }, "minX" : 1590, "maxX" : 1691, "minY" : 2752, "maxY" : 2831, "prop" : { "x" : 1590, "y" : 2795, "width" : 101, "height" : 36 }, "textPosition" : { "x" : 1609, "y" : 2789 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133305, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1640, "y" : 2789 }, "to" : { "x" : 1640, "y" : 2752 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133307, "reactomeId" : 10435563, "displayName" : "GNRHR:GNRHR peptide agonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 1589, "y" : 2703 }, "minX" : 1537, "maxX" : 1648, "minY" : 2680, "maxY" : 2721, "prop" : { "x" : 1537, "y" : 2686, "width" : 105, "height" : 35 }, "textPosition" : { "x" : 1538, "y" : 2672 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1642, "y" : 2686 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1642, "y" : 2686 } } }, "connectors" : [ { "edgeId" : 133305, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133304, "reactomeId" : 10435559, "displayName" : "PTGFR:PTGFR agonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 1540, "y" : 2482 }, "minX" : 1494, "maxX" : 1593, "minY" : 2458, "maxY" : 2500, "prop" : { "x" : 1494, "y" : 2464, "width" : 93, "height" : 36 }, "textPosition" : { "x" : 1494, "y" : 2465 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1587, "y" : 2464 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1587, "y" : 2464 } } }, "connectors" : [ { "edgeId" : 133302, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133310, "reactomeId" : 10435571, "displayName" : "GNRHR:GNRHR peptide antagonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 1714, "y" : 2703 }, "minX" : 1653, "maxX" : 1781, "minY" : 2679, "maxY" : 2721, "prop" : { "x" : 1653, "y" : 2685, "width" : 122, "height" : 36 }, "textPosition" : { "x" : 1663, "y" : 2672 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1775, "y" : 2685 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1775, "y" : 2685 } } }, "connectors" : [ { "edgeId" : 133308, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133309, "reactomeId" : 9718382, "displayName" : "GNRHR peptide antagonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 1778, "y" : 2850 }, "minX" : 1728, "maxX" : 1829, "minY" : 2780, "maxY" : 2868, "prop" : { "x" : 1728, "y" : 2832, "width" : 101, "height" : 36 }, "textPosition" : { "x" : 1737, "y" : 2826 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133308, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1777, "y" : 2826 }, "to" : { "x" : 1777, "y" : 2780 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133315, "reactomeId" : 9731346, "displayName" : "non-selective ERAs", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 1822, "y" : 2365 }, "minX" : 1778, "maxX" : 1867, "minY" : 2352, "maxY" : 2415, "prop" : { "x" : 1778, "y" : 2352, "width" : 89, "height" : 27 }, "textPosition" : { "x" : 1789, "y" : 2341 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133314, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1821, "y" : 2385 }, "to" : { "x" : 1821, "y" : 2415 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133312, "reactomeId" : 9724480, "displayName" : "GNRHR chemical antagonists", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 1952, "y" : 2862 }, "minX" : 1824, "maxX" : 2007, "minY" : 2804, "maxY" : 2880, "prop" : { "x" : 1897, "y" : 2844, "width" : 110, "height" : 36 }, "textPosition" : { "x" : 1895, "y" : 2844 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133311, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1912, "y" : 2838 }, "to" : { "x" : 1824, "y" : 2804 } }, { "from" : { "x" : 1824, "y" : 2804 }, "to" : { "x" : 1953, "y" : 2804 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133313, "reactomeId" : 10435567, "displayName" : "GNRHR:GNRHR chemical antagonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 2031, "y" : 2697 }, "minX" : 1978, "maxX" : 2091, "minY" : 2667, "maxY" : 2722, "prop" : { "x" : 1978, "y" : 2673, "width" : 107, "height" : 49 }, "textPosition" : { "x" : 1980, "y" : 2673 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2085, "y" : 2673 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2085, "y" : 2673 } } }, "connectors" : [ { "edgeId" : 133311, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133318, "reactomeId" : 10358168, "displayName" : "EDNRA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2151, "y" : 2480 }, "minX" : 2117, "maxX" : 2185, "minY" : 2405, "maxY" : 2492, "prop" : { "x" : 2126, "y" : 2469, "width" : 50, "height" : 23 }, "textPosition" : { "x" : 2126, "y" : 2470 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2176, "y" : 2469 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2176, "y" : 2469 } } }, "connectors" : [ { "edgeId" : 133317, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2145, "y" : 2466 }, "to" : { "x" : 2117, "y" : 2409 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133320, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2156, "y" : 2466 }, "to" : { "x" : 2185, "y" : 2405 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133319, "reactomeId" : 10435758, "displayName" : "EDNRA:EDNs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2084, "y" : 2478 }, "minX" : 2055, "maxX" : 2120, "minY" : 2454, "maxY" : 2496, "prop" : { "x" : 2055, "y" : 2460, "width" : 59, "height" : 36 }, "textPosition" : { "x" : 2057, "y" : 2461 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2114, "y" : 2460 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2114, "y" : 2460 } } }, "connectors" : [ { "edgeId" : 133317, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133316, "reactomeId" : 10435745, "displayName" : "EDNRA,EDNRB:non-selective ERAs", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 1801, "y" : 2477 }, "minX" : 1748, "maxX" : 1861, "minY" : 2448, "maxY" : 2500, "prop" : { "x" : 1748, "y" : 2454, "width" : 107, "height" : 46 }, "textPosition" : { "x" : 1751, "y" : 2451 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1855, "y" : 2454 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1855, "y" : 2454 } } }, "connectors" : [ { "edgeId" : 133314, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133322, "reactomeId" : 10435762, "displayName" : "EDNRA:selective ERAs", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 2243, "y" : 2481 }, "minX" : 2190, "maxX" : 2303, "minY" : 2457, "maxY" : 2500, "prop" : { "x" : 2190, "y" : 2463, "width" : 107, "height" : 37 }, "textPosition" : { "x" : 2194, "y" : 2465 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2297, "y" : 2463 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2297, "y" : 2463 } } }, "connectors" : [ { "edgeId" : 133320, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133321, "reactomeId" : 9731926, "displayName" : "selective ERAs", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 2185, "y" : 2353 }, "minX" : 2140, "maxX" : 2231, "minY" : 2342, "maxY" : 2405, "prop" : { "x" : 2140, "y" : 2342, "width" : 91, "height" : 23 }, "textPosition" : { "x" : 2152, "y" : 2336 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 133320, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2185, "y" : 2371 }, "to" : { "x" : 2185, "y" : 2405 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133329, "reactomeId" : 10358512, "displayName" : "FFAR4:FFAR4 ligands", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3733, "y" : 1962 }, "minX" : 3684, "maxX" : 3788, "minY" : 1938, "maxY" : 1981, "prop" : { "x" : 3684, "y" : 1944, "width" : 98, "height" : 37 }, "textPosition" : { "x" : 3687, "y" : 1946 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3782, "y" : 1944 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3782, "y" : 1944 } } }, "connectors" : [ ] }, { "id" : 133334, "reactomeId" : 10358162, "displayName" : "EDN3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 912, "y" : 540 }, "minX" : 864, "maxX" : 967, "minY" : 523, "maxY" : 551, "prop" : { "x" : 864, "y" : 529, "width" : 97, "height" : 22 }, "textPosition" : { "x" : 891, "y" : 529 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 961, "y" : 529 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 961, "y" : 529 } } }, "connectors" : [ ] }, { "id" : 133332, "reactomeId" : 10358460, "displayName" : "Acyl ghrelin:GHSR", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2596, "y" : 2231 }, "minX" : 2547, "maxX" : 2651, "minY" : 2207, "maxY" : 2250, "prop" : { "x" : 2547, "y" : 2213, "width" : 98, "height" : 37 }, "textPosition" : { "x" : 2554, "y" : 2215 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2645, "y" : 2213 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2645, "y" : 2213 } } }, "connectors" : [ ] }, { "id" : 133339, "reactomeId" : 10443294, "displayName" : "G alpha (i) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2591, "y" : 214 }, "minX" : 2508, "maxX" : 2674, "minY" : 174, "maxY" : 255, "prop" : { "x" : 2508, "y" : 174, "width" : 166, "height" : 81 }, "textPosition" : { "x" : 2517, "y" : 193 }, "connectors" : [ ] }, { "id" : 133342, "reactomeId" : 10443408, "displayName" : "G alpha (q) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2079, "y" : 753 }, "minX" : 2014, "maxX" : 2144, "minY" : 705, "maxY" : 801, "prop" : { "x" : 2014, "y" : 705, "width" : 130, "height" : 96 }, "textPosition" : { "x" : 2018, "y" : 731 }, "connectors" : [ ] }, { "id" : 133343, "reactomeId" : 10443348, "displayName" : "G alpha (s) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 544, "y" : 763 }, "minX" : 479, "maxX" : 609, "minY" : 717, "maxY" : 810, "prop" : { "x" : 479, "y" : 717, "width" : 130, "height" : 93 }, "textPosition" : { "x" : 483, "y" : 742 }, "connectors" : [ ] }, { "id" : 133340, "reactomeId" : 10443408, "displayName" : "G alpha (q) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 822, "y" : 236 }, "minX" : 743, "maxX" : 902, "minY" : 200, "maxY" : 273, "prop" : { "x" : 743, "y" : 200, "width" : 159, "height" : 73 }, "textPosition" : { "x" : 746, "y" : 215 }, "connectors" : [ ] }, { "id" : 133341, "reactomeId" : 10443348, "displayName" : "G alpha (s) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 600, "y" : 2627 }, "minX" : 525, "maxX" : 675, "minY" : 2601, "maxY" : 2654, "prop" : { "x" : 525, "y" : 2601, "width" : 150, "height" : 53 }, "textPosition" : { "x" : 524, "y" : 2606 }, "connectors" : [ ] }, { "id" : 133346, "reactomeId" : 10444490, "displayName" : "G alpha (z) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2507, "y" : 810 }, "minX" : 2431, "maxX" : 2584, "minY" : 773, "maxY" : 847, "prop" : { "x" : 2431, "y" : 773, "width" : 153, "height" : 74 }, "textPosition" : { "x" : 2432, "y" : 788 }, "connectors" : [ ] }, { "id" : 133344, "reactomeId" : 10443294, "displayName" : "G alpha (i) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 3545, "y" : 744 }, "minX" : 3470, "maxX" : 3620, "minY" : 697, "maxY" : 792, "prop" : { "x" : 3470, "y" : 697, "width" : 150, "height" : 95 }, "textPosition" : { "x" : 3471, "y" : 723 }, "connectors" : [ ] }, { "id" : 133350, "reactomeId" : 10443348, "displayName" : "G alpha (s) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 3050, "y" : 1333 }, "minX" : 2977, "maxX" : 3124, "minY" : 1303, "maxY" : 1363, "prop" : { "x" : 2977, "y" : 1303, "width" : 147, "height" : 60 }, "textPosition" : { "x" : 2990, "y" : 1311 }, "connectors" : [ ] }, { "id" : 133351, "reactomeId" : 10443394, "displayName" : "G alpha (12/13) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1344, "y" : 1529 }, "minX" : 1283, "maxX" : 1405, "minY" : 1494, "maxY" : 1565, "prop" : { "x" : 1283, "y" : 1494, "width" : 122, "height" : 71 }, "textPosition" : { "x" : 1283, "y" : 1508 }, "connectors" : [ ] }, { "id" : 133348, "reactomeId" : 10443294, "displayName" : "G alpha (i) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1314, "y" : 1332 }, "minX" : 1254, "maxX" : 1374, "minY" : 1295, "maxY" : 1369, "prop" : { "x" : 1254, "y" : 1295, "width" : 120, "height" : 74 }, "textPosition" : { "x" : 1271, "y" : 1303 }, "connectors" : [ ] }, { "id" : 133349, "reactomeId" : 10443408, "displayName" : "G alpha (q) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2210, "y" : 1331 }, "minX" : 2129, "maxX" : 2292, "minY" : 1294, "maxY" : 1368, "prop" : { "x" : 2129, "y" : 1294, "width" : 163, "height" : 74 }, "textPosition" : { "x" : 2134, "y" : 1309 }, "connectors" : [ ] }, { "id" : 133354, "reactomeId" : 10443408, "displayName" : "G alpha (q) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2725, "y" : 2145 }, "minX" : 2659, "maxX" : 2792, "minY" : 2116, "maxY" : 2174, "prop" : { "x" : 2659, "y" : 2116, "width" : 133, "height" : 58 }, "textPosition" : { "x" : 2665, "y" : 2123 }, "connectors" : [ ] }, { "id" : 133355, "reactomeId" : 10443348, "displayName" : "G alpha (s) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 3238, "y" : 2158 }, "minX" : 3159, "maxX" : 3318, "minY" : 2132, "maxY" : 2185, "prop" : { "x" : 3159, "y" : 2132, "width" : 159, "height" : 53 }, "textPosition" : { "x" : 3162, "y" : 2137 }, "connectors" : [ ] }, { "id" : 133353, "reactomeId" : 10443294, "displayName" : "G alpha (i) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1130, "y" : 2106 }, "minX" : 1073, "maxX" : 1188, "minY" : 2074, "maxY" : 2138, "prop" : { "x" : 1073, "y" : 2074, "width" : 115, "height" : 64 }, "textPosition" : { "x" : 1088, "y" : 2077 }, "connectors" : [ ] }, { "id" : 133358, "reactomeId" : 10443294, "displayName" : "G alpha (i) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2703, "y" : 2593 }, "minX" : 2646, "maxX" : 2761, "minY" : 2561, "maxY" : 2625, "prop" : { "x" : 2646, "y" : 2561, "width" : 115, "height" : 64 }, "textPosition" : { "x" : 2661, "y" : 2564 }, "connectors" : [ ] }, { "id" : 133359, "reactomeId" : 10444608, "displayName" : "Sphingolipid metabolism", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2853, "y" : 2797 }, "minX" : 2800, "maxX" : 2906, "minY" : 2768, "maxY" : 2827, "prop" : { "x" : 2800, "y" : 2768, "width" : 106, "height" : 59 }, "textPosition" : { "x" : 2805, "y" : 2776 }, "connectors" : [ ] }, { "id" : 133357, "reactomeId" : 10443408, "displayName" : "G alpha (q) signalling events", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 826, "y" : 2564 }, "minX" : 753, "maxX" : 899, "minY" : 2535, "maxY" : 2593, "prop" : { "x" : 753, "y" : 2535, "width" : 146, "height" : 58 }, "textPosition" : { "x" : 765, "y" : 2542 }, "connectors" : [ ] }, { "id" : 132690, "reactomeId" : 10356719, "displayName" : "AGT", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 545, "y" : 30 }, "minX" : 442, "maxX" : 639, "minY" : 12, "maxY" : 51, "prop" : { "x" : 504, "y" : 18, "width" : 82, "height" : 25 }, "textPosition" : { "x" : 529, "y" : 20 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 586, "y" : 18 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 586, "y" : 18 } } }, "connectors" : [ { "edgeId" : 132689, "type" : "INPUT", "segments" : [ { "from" : { "x" : 501, "y" : 38 }, "to" : { "x" : 442, "y" : 51 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133215, "type" : "INPUT", "segments" : [ { "from" : { "x" : 589, "y" : 36 }, "to" : { "x" : 639, "y" : 44 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132691, "reactomeId" : 10356715, "displayName" : "AGTR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 392, "y" : 83 }, "minX" : 343, "maxX" : 442, "minY" : 51, "maxY" : 94, "prop" : { "x" : 367, "y" : 72, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 368, "y" : 72 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 418, "y" : 72 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 418, "y" : 72 } } }, "connectors" : [ { "edgeId" : 132689, "type" : "INPUT", "segments" : [ { "from" : { "x" : 409, "y" : 69 }, "to" : { "x" : 442, "y" : 51 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133213, "type" : "INPUT", "segments" : [ { "from" : { "x" : 374, "y" : 69 }, "to" : { "x" : 343, "y" : 52 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132695, "reactomeId" : 10356828, "displayName" : "APLNR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3222, "y" : 86 }, "minX" : 3191, "maxX" : 3285, "minY" : 65, "maxY" : 101, "prop" : { "x" : 3191, "y" : 71, "width" : 62, "height" : 30 }, "textPosition" : { "x" : 3198, "y" : 75 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3253, "y" : 71 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3253, "y" : 71 } } }, "connectors" : [ { "edgeId" : 132694, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3256, "y" : 76 }, "to" : { "x" : 3285, "y" : 66 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132692, "reactomeId" : 10356721, "displayName" : "AGTR1:AGT(25-32)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 503, "y" : 91 }, "minX" : 464, "maxX" : 549, "minY" : 66, "maxY" : 110, "prop" : { "x" : 464, "y" : 72, "width" : 79, "height" : 38 }, "textPosition" : { "x" : 465, "y" : 75 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 543, "y" : 72 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 543, "y" : 72 } } }, "connectors" : [ { "edgeId" : 132689, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132693, "reactomeId" : 10356723, "displayName" : "ARBs:AGTR1", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 301, "y" : 89 }, "minX" : 271, "maxX" : 444, "minY" : 59, "maxY" : 115, "prop" : { "x" : 271, "y" : 73, "width" : 61, "height" : 33 }, "textPosition" : { "x" : 277, "y" : 71 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 332, "y" : 73 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 332, "y" : 73 } } }, "connectors" : [ { "edgeId" : 132689, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 335, "y" : 94 }, "to" : { "x" : 440, "y" : 115 } }, { "from" : { "x" : 440, "y" : 115 }, "to" : { "x" : 440, "y" : 59 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 436, "y" : 59 }, "b" : { "x" : 444, "y" : 59 }, "c" : { "x" : 440, "y" : 59 }, "type" : "STOP", "centre" : { "x" : 440, "y" : 59 } } }, { "edgeId" : 133213, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132699, "reactomeId" : 10357108, "displayName" : "Bombesin-like receptor", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 793, "y" : 81 }, "minX" : 748, "maxX" : 859, "minY" : 54, "maxY" : 100, "prop" : { "x" : 748, "y" : 62, "width" : 91, "height" : 38 }, "textPosition" : { "x" : 750, "y" : 63 }, "connectors" : [ { "edgeId" : 132698, "type" : "INPUT", "segments" : [ { "from" : { "x" : 845, "y" : 62 }, "to" : { "x" : 859, "y" : 54 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132696, "reactomeId" : 10356818, "displayName" : "APLN", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3223, "y" : 37 }, "minX" : 3176, "maxX" : 3285, "minY" : 16, "maxY" : 66, "prop" : { "x" : 3176, "y" : 22, "width" : 95, "height" : 31 }, "textPosition" : { "x" : 3204, "y" : 27 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3271, "y" : 22 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3271, "y" : 22 } } }, "connectors" : [ { "edgeId" : 132694, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3256, "y" : 59 }, "to" : { "x" : 3285, "y" : 66 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132697, "reactomeId" : 10356830, "displayName" : "APLNR:Apelin peptides", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3388, "y" : 86 }, "minX" : 3336, "maxX" : 3446, "minY" : 60, "maxY" : 106, "prop" : { "x" : 3336, "y" : 66, "width" : 104, "height" : 40 }, "textPosition" : { "x" : 3341, "y" : 71 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3440, "y" : 66 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3440, "y" : 66 } } }, "connectors" : [ { "edgeId" : 132694, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132703, "reactomeId" : 10356806, "displayName" : "KNG1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1080, "y" : 27 }, "minX" : 1044, "maxX" : 1144, "minY" : 9, "maxY" : 55, "prop" : { "x" : 1044, "y" : 15, "width" : 73, "height" : 24 }, "textPosition" : { "x" : 1060, "y" : 16 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1117, "y" : 15 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1117, "y" : 15 } } }, "connectors" : [ { "edgeId" : 132702, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1107, "y" : 42 }, "to" : { "x" : 1144, "y" : 55 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132700, "reactomeId" : 10357094, "displayName" : "GRP", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 794, "y" : 25 }, "minX" : 749, "maxX" : 859, "minY" : 0, "maxY" : 54, "prop" : { "x" : 749, "y" : 6, "width" : 91, "height" : 38 }, "textPosition" : { "x" : 778, "y" : 14 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 840, "y" : 6 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 840, "y" : 6 } } }, "connectors" : [ { "edgeId" : 132698, "type" : "INPUT", "segments" : [ { "from" : { "x" : 836, "y" : 50 }, "to" : { "x" : 859, "y" : 54 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132701, "reactomeId" : 10357110, "displayName" : "Bombesin-like receptor:bombesin-like peptide", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 961, "y" : 81 }, "minX" : 903, "maxX" : 1025, "minY" : 44, "maxY" : 113, "prop" : { "x" : 903, "y" : 50, "width" : 116, "height" : 63 }, "textPosition" : { "x" : 912, "y" : 50 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1019, "y" : 50 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1019, "y" : 50 } } }, "connectors" : [ { "edgeId" : 132698, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132707, "reactomeId" : 10346309, "displayName" : "C5", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1520, "y" : 42 }, "minX" : 1505, "maxX" : 1559, "minY" : 25, "maxY" : 56, "prop" : { "x" : 1505, "y" : 31, "width" : 31, "height" : 23 }, "textPosition" : { "x" : 1508, "y" : 32 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1536, "y" : 31 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1536, "y" : 31 } } }, "connectors" : [ { "edgeId" : 132706, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1539, "y" : 47 }, "to" : { "x" : 1559, "y" : 56 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132704, "reactomeId" : 10356810, "displayName" : "BDKRB2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1087, "y" : 78 }, "minX" : 1032, "maxX" : 1149, "minY" : 55, "maxY" : 95, "prop" : { "x" : 1032, "y" : 61, "width" : 111, "height" : 34 }, "textPosition" : { "x" : 1059, "y" : 67 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1143, "y" : 61 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1143, "y" : 61 } } }, "connectors" : [ { "edgeId" : 132702, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1129, "y" : 55 }, "to" : { "x" : 1144, "y" : 55 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132705, "reactomeId" : 10356812, "displayName" : "Bradykinin receptor:Bradykinin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1239, "y" : 85 }, "minX" : 1197, "maxX" : 1287, "minY" : 55, "maxY" : 110, "prop" : { "x" : 1197, "y" : 61, "width" : 84, "height" : 49 }, "textPosition" : { "x" : 1201, "y" : 61 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1281, "y" : 61 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1281, "y" : 61 } } }, "connectors" : [ { "edgeId" : 132702, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132711, "reactomeId" : 10345132, "displayName" : "C3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1715, "y" : 42 }, "minX" : 1700, "maxX" : 1748, "minY" : 25, "maxY" : 54, "prop" : { "x" : 1700, "y" : 31, "width" : 31, "height" : 23 }, "textPosition" : { "x" : 1703, "y" : 32 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1731, "y" : 31 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1731, "y" : 31 } } }, "connectors" : [ { "edgeId" : 132710, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1734, "y" : 45 }, "to" : { "x" : 1748, "y" : 50 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132708, "reactomeId" : 10357116, "displayName" : "C5AR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1526, "y" : 82 }, "minX" : 1497, "maxX" : 1561, "minY" : 56, "maxY" : 96, "prop" : { "x" : 1497, "y" : 69, "width" : 58, "height" : 27 }, "textPosition" : { "x" : 1502, "y" : 72 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1555, "y" : 69 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1555, "y" : 69 } } }, "connectors" : [ { "edgeId" : 132706, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1543, "y" : 66 }, "to" : { "x" : 1559, "y" : 56 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132709, "reactomeId" : 10357118, "displayName" : "C5AR1:C5a", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1622, "y" : 77 }, "minX" : 1580, "maxX" : 1670, "minY" : 58, "maxY" : 90, "prop" : { "x" : 1580, "y" : 64, "width" : 84, "height" : 26 }, "textPosition" : { "x" : 1584, "y" : 69 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1664, "y" : 64 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1664, "y" : 64 } } }, "connectors" : [ { "edgeId" : 132706, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132715, "reactomeId" : 10356677, "displayName" : "CXCL8", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1319, "y" : 31 }, "minX" : 1306, "maxX" : 1369, "minY" : 14, "maxY" : 58, "prop" : { "x" : 1306, "y" : 20, "width" : 26, "height" : 22 }, "textPosition" : { "x" : 1307, "y" : 7 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1332, "y" : 20 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1332, "y" : 20 } } }, "connectors" : [ { "edgeId" : 132714, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1335, "y" : 38 }, "to" : { "x" : 1369, "y" : 58 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132712, "reactomeId" : 10358565, "displayName" : "C3AR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1724, "y" : 81 }, "minX" : 1690, "maxX" : 1764, "minY" : 50, "maxY" : 95, "prop" : { "x" : 1690, "y" : 68, "width" : 68, "height" : 27 }, "textPosition" : { "x" : 1700, "y" : 71 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1758, "y" : 68 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1758, "y" : 68 } } }, "connectors" : [ { "edgeId" : 132710, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1734, "y" : 65 }, "to" : { "x" : 1748, "y" : 50 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132713, "reactomeId" : 10358567, "displayName" : "C3AR1:C3a", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1831, "y" : 77 }, "minX" : 1796, "maxX" : 1872, "minY" : 53, "maxY" : 96, "prop" : { "x" : 1796, "y" : 59, "width" : 70, "height" : 37 }, "textPosition" : { "x" : 1805, "y" : 61 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1866, "y" : 59 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1866, "y" : 59 } } }, "connectors" : [ { "edgeId" : 132710, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132719, "reactomeId" : 10356925, "displayName" : "Neuropeptides B/W", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2161, "y" : 20 }, "minX" : 2105, "maxX" : 2218, "minY" : 6, "maxY" : 44, "prop" : { "x" : 2105, "y" : 6, "width" : 113, "height" : 29 }, "textPosition" : { "x" : 2109, "y" : 3 }, "connectors" : [ { "edgeId" : 132718, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2192, "y" : 41 }, "to" : { "x" : 2213, "y" : 44 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132716, "reactomeId" : 10356762, "displayName" : "ACKR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1343, "y" : 82 }, "minX" : 1318, "maxX" : 1375, "minY" : 58, "maxY" : 96, "prop" : { "x" : 1318, "y" : 69, "width" : 51, "height" : 27 }, "textPosition" : { "x" : 1320, "y" : 72 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1369, "y" : 69 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1369, "y" : 69 } } }, "connectors" : [ { "edgeId" : 132714, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1357, "y" : 66 }, "to" : { "x" : 1369, "y" : 58 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132717, "reactomeId" : 10356764, "displayName" : "DARC:IL8", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1428, "y" : 85 }, "minX" : 1396, "maxX" : 1466, "minY" : 67, "maxY" : 97, "prop" : { "x" : 1396, "y" : 73, "width" : 64, "height" : 24 }, "textPosition" : { "x" : 1397, "y" : 76 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1460, "y" : 73 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1460, "y" : 73 } } }, "connectors" : [ { "edgeId" : 132714, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132723, "reactomeId" : 10356869, "displayName" : "PNOC", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2415, "y" : 37 }, "minX" : 2378, "maxX" : 2469, "minY" : 15, "maxY" : 65, "prop" : { "x" : 2378, "y" : 21, "width" : 74, "height" : 33 }, "textPosition" : { "x" : 2394, "y" : 27 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2452, "y" : 21 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2452, "y" : 21 } } }, "connectors" : [ { "edgeId" : 132722, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2446, "y" : 57 }, "to" : { "x" : 2469, "y" : 65 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132720, "reactomeId" : 10356935, "displayName" : "Neuropeptides B/W receptors", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2163, "y" : 75 }, "minX" : 2104, "maxX" : 2222, "minY" : 44, "maxY" : 94, "prop" : { "x" : 2104, "y" : 56, "width" : 118, "height" : 38 }, "textPosition" : { "x" : 2110, "y" : 57 }, "connectors" : [ { "edgeId" : 132718, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2193, "y" : 50 }, "to" : { "x" : 2213, "y" : 44 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132721, "reactomeId" : 10356937, "displayName" : "Neuropeptides B/W receptor:neuropeptides B/W", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2314, "y" : 82 }, "minX" : 2262, "maxX" : 2372, "minY" : 45, "maxY" : 113, "prop" : { "x" : 2262, "y" : 51, "width" : 104, "height" : 62 }, "textPosition" : { "x" : 2262, "y" : 50 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2366, "y" : 51 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2366, "y" : 51 } } }, "connectors" : [ { "edgeId" : 132718, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132727, "reactomeId" : 10356800, "displayName" : "Opioid ligands", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2701, "y" : 22 }, "minX" : 2653, "maxX" : 2749, "minY" : 9, "maxY" : 50, "prop" : { "x" : 2653, "y" : 9, "width" : 96, "height" : 26 }, "textPosition" : { "x" : 2653, "y" : 11 }, "connectors" : [ { "edgeId" : 132726, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2714, "y" : 41 }, "to" : { "x" : 2729, "y" : 50 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132724, "reactomeId" : 10356873, "displayName" : "OPRL1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2415, "y" : 87 }, "minX" : 2380, "maxX" : 2469, "minY" : 65, "maxY" : 102, "prop" : { "x" : 2380, "y" : 72, "width" : 70, "height" : 30 }, "textPosition" : { "x" : 2391, "y" : 76 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2450, "y" : 72 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2450, "y" : 72 } } }, "connectors" : [ { "edgeId" : 132722, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2453, "y" : 72 }, "to" : { "x" : 2469, "y" : 65 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132725, "reactomeId" : 10356875, "displayName" : "Nociceptin receptor:Nociceptin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2572, "y" : 81 }, "minX" : 2513, "maxX" : 2638, "minY" : 50, "maxY" : 107, "prop" : { "x" : 2513, "y" : 56, "width" : 119, "height" : 51 }, "textPosition" : { "x" : 2533, "y" : 58 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2632, "y" : 56 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2632, "y" : 56 } } }, "connectors" : [ { "edgeId" : 132722, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132731, "reactomeId" : 10356432, "displayName" : "CCL27,28", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3859, "y" : 429 }, "minX" : 3826, "maxX" : 3901, "minY" : 395, "maxY" : 442, "prop" : { "x" : 3826, "y" : 416, "width" : 66, "height" : 26 }, "textPosition" : { "x" : 3826, "y" : 418 }, "connectors" : [ { "edgeId" : 132730, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3875, "y" : 410 }, "to" : { "x" : 3901, "y" : 395 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132728, "reactomeId" : 10356776, "displayName" : "Opioid receptors", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2707, "y" : 82 }, "minX" : 2654, "maxX" : 2760, "minY" : 50, "maxY" : 98, "prop" : { "x" : 2654, "y" : 66, "width" : 106, "height" : 32 }, "textPosition" : { "x" : 2672, "y" : 65 }, "connectors" : [ { "edgeId" : 132726, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2718, "y" : 60 }, "to" : { "x" : 2729, "y" : 50 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132729, "reactomeId" : 10356802, "displayName" : "Opioid receptor:opioid ligand", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2834, "y" : 76 }, "minX" : 2786, "maxX" : 2889, "minY" : 46, "maxY" : 101, "prop" : { "x" : 2786, "y" : 52, "width" : 97, "height" : 49 }, "textPosition" : { "x" : 2790, "y" : 52 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2883, "y" : 52 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2883, "y" : 52 } } }, "connectors" : [ { "edgeId" : 132726, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132735, "reactomeId" : 10356444, "displayName" : "CCL20", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1915, "y" : 434 }, "minX" : 1882, "maxX" : 1955, "minY" : 408, "maxY" : 449, "prop" : { "x" : 1882, "y" : 420, "width" : 67, "height" : 29 }, "textPosition" : { "x" : 1892, "y" : 424 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1949, "y" : 420 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1949, "y" : 420 } } }, "connectors" : [ { "edgeId" : 132734, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1928, "y" : 417 }, "to" : { "x" : 1940, "y" : 408 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132732, "reactomeId" : 10356422, "displayName" : "CCR10", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3854, "y" : 367 }, "minX" : 3830, "maxX" : 3901, "minY" : 350, "maxY" : 395, "prop" : { "x" : 3830, "y" : 356, "width" : 49, "height" : 23 }, "textPosition" : { "x" : 3830, "y" : 357 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3879, "y" : 356 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3879, "y" : 356 } } }, "connectors" : [ { "edgeId" : 132730, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3873, "y" : 382 }, "to" : { "x" : 3901, "y" : 395 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132733, "reactomeId" : 10356434, "displayName" : "CCR10:CCL27,28", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3992, "y" : 361 }, "minX" : 3947, "maxX" : 4043, "minY" : 338, "maxY" : 378, "prop" : { "x" : 3947, "y" : 344, "width" : 90, "height" : 34 }, "textPosition" : { "x" : 3959, "y" : 343 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4037, "y" : 344 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4037, "y" : 344 } } }, "connectors" : [ { "edgeId" : 132730, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132739, "reactomeId" : 10356338, "displayName" : "CCL19,21", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3121, "y" : 429 }, "minX" : 3087, "maxX" : 3156, "minY" : 395, "maxY" : 443, "prop" : { "x" : 3087, "y" : 416, "width" : 69, "height" : 27 }, "textPosition" : { "x" : 3088, "y" : 419 }, "connectors" : [ { "edgeId" : 132738, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3131, "y" : 410 }, "to" : { "x" : 3147, "y" : 395 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132736, "reactomeId" : 10356440, "displayName" : "CCR6", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1905, "y" : 372 }, "minX" : 1881, "maxX" : 1940, "minY" : 352, "maxY" : 408, "prop" : { "x" : 1881, "y" : 358, "width" : 49, "height" : 29 }, "textPosition" : { "x" : 1885, "y" : 362 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1930, "y" : 358 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1930, "y" : 358 } } }, "connectors" : [ { "edgeId" : 132734, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1919, "y" : 390 }, "to" : { "x" : 1940, "y" : 408 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132737, "reactomeId" : 10356446, "displayName" : "CCR6:CCL20", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2019, "y" : 372 }, "minX" : 1992, "maxX" : 2052, "minY" : 348, "maxY" : 391, "prop" : { "x" : 1992, "y" : 354, "width" : 54, "height" : 37 }, "textPosition" : { "x" : 1996, "y" : 356 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2046, "y" : 354 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2046, "y" : 354 } } }, "connectors" : [ { "edgeId" : 132734, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132743, "reactomeId" : 10356372, "displayName" : "CCR9", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3285, "y" : 365 }, "minX" : 3265, "maxX" : 3312, "minY" : 348, "maxY" : 395, "prop" : { "x" : 3265, "y" : 354, "width" : 41, "height" : 22 }, "textPosition" : { "x" : 3265, "y" : 354 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3306, "y" : 354 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3306, "y" : 354 } } }, "connectors" : [ { "edgeId" : 132742, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3291, "y" : 379 }, "to" : { "x" : 3302, "y" : 395 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132740, "reactomeId" : 10356328, "displayName" : "CCR7", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3118, "y" : 364 }, "minX" : 3096, "maxX" : 3147, "minY" : 344, "maxY" : 395, "prop" : { "x" : 3096, "y" : 350, "width" : 44, "height" : 28 }, "textPosition" : { "x" : 3098, "y" : 353 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3140, "y" : 350 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3140, "y" : 350 } } }, "connectors" : [ { "edgeId" : 132738, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3131, "y" : 381 }, "to" : { "x" : 3147, "y" : 395 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132741, "reactomeId" : 10356340, "displayName" : "CCR7:CCL19,21", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3218, "y" : 361 }, "minX" : 3184, "maxX" : 3258, "minY" : 337, "maxY" : 379, "prop" : { "x" : 3184, "y" : 343, "width" : 68, "height" : 36 }, "textPosition" : { "x" : 3185, "y" : 344 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3252, "y" : 343 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3252, "y" : 343 } } }, "connectors" : [ { "edgeId" : 132738, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132747, "reactomeId" : 10356476, "displayName" : "CX3CR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3483, "y" : 88 }, "minX" : 3454, "maxX" : 3526, "minY" : 63, "maxY" : 105, "prop" : { "x" : 3454, "y" : 72, "width" : 58, "height" : 33 }, "textPosition" : { "x" : 3455, "y" : 78 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3512, "y" : 72 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3512, "y" : 72 } } }, "connectors" : [ { "edgeId" : 132746, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3511, "y" : 69 }, "to" : { "x" : 3526, "y" : 63 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132744, "reactomeId" : 10356368, "displayName" : "CCL25", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3285, "y" : 422 }, "minX" : 3259, "maxX" : 3318, "minY" : 395, "maxY" : 436, "prop" : { "x" : 3259, "y" : 409, "width" : 53, "height" : 27 }, "textPosition" : { "x" : 3262, "y" : 412 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3312, "y" : 409 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3312, "y" : 409 } } }, "connectors" : [ { "edgeId" : 132742, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3293, "y" : 406 }, "to" : { "x" : 3302, "y" : 395 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132745, "reactomeId" : 10356374, "displayName" : "CCR9:CCL25", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3368, "y" : 362 }, "minX" : 3339, "maxX" : 3404, "minY" : 337, "maxY" : 381, "prop" : { "x" : 3339, "y" : 343, "width" : 59, "height" : 38 }, "textPosition" : { "x" : 3345, "y" : 346 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3398, "y" : 343 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3398, "y" : 343 } } }, "connectors" : [ { "edgeId" : 132742, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132751, "reactomeId" : 10356464, "displayName" : "XCR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 754, "y" : 367 }, "minX" : 726, "maxX" : 799, "minY" : 348, "maxY" : 392, "prop" : { "x" : 726, "y" : 354, "width" : 57, "height" : 27 }, "textPosition" : { "x" : 735, "y" : 357 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 783, "y" : 354 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 783, "y" : 354 } } }, "connectors" : [ { "edgeId" : 132750, "type" : "INPUT", "segments" : [ { "from" : { "x" : 778, "y" : 384 }, "to" : { "x" : 799, "y" : 392 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132748, "reactomeId" : 10356472, "displayName" : "A0A3Q1LPV5", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3481, "y" : 44 }, "minX" : 3453, "maxX" : 3526, "minY" : 23, "maxY" : 63, "prop" : { "x" : 3453, "y" : 29, "width" : 56, "height" : 30 }, "textPosition" : { "x" : 3456, "y" : 27 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3509, "y" : 29 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3509, "y" : 29 } } }, "connectors" : [ { "edgeId" : 132746, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3512, "y" : 55 }, "to" : { "x" : 3526, "y" : 63 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132749, "reactomeId" : 10356478, "displayName" : "CX3CR1:CX3CL1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3606, "y" : 88 }, "minX" : 3572, "maxX" : 3646, "minY" : 64, "maxY" : 107, "prop" : { "x" : 3572, "y" : 70, "width" : 68, "height" : 37 }, "textPosition" : { "x" : 3576, "y" : 72 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3640, "y" : 70 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3640, "y" : 70 } } }, "connectors" : [ { "edgeId" : 132746, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132755, "reactomeId" : 10356669, "displayName" : "Homologues of CXCR1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1024, "y" : 365 }, "minX" : 992, "maxX" : 1072, "minY" : 349, "maxY" : 401, "prop" : { "x" : 992, "y" : 349, "width" : 65, "height" : 32 }, "textPosition" : { "x" : 993, "y" : 341 }, "connectors" : [ { "edgeId" : 132754, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1045, "y" : 384 }, "to" : { "x" : 1072, "y" : 401 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132752, "reactomeId" : 10356460, "displayName" : "XCL1,XCL2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 756, "y" : 420 }, "minX" : 717, "maxX" : 799, "minY" : 392, "maxY" : 431, "prop" : { "x" : 717, "y" : 409, "width" : 79, "height" : 22 }, "textPosition" : { "x" : 721, "y" : 409 }, "connectors" : [ { "edgeId" : 132750, "type" : "INPUT", "segments" : [ { "from" : { "x" : 772, "y" : 403 }, "to" : { "x" : 799, "y" : 392 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132753, "reactomeId" : 10356466, "displayName" : "XCR1:XCL1,XCL2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 891, "y" : 370 }, "minX" : 844, "maxX" : 945, "minY" : 346, "maxY" : 389, "prop" : { "x" : 844, "y" : 352, "width" : 95, "height" : 37 }, "textPosition" : { "x" : 853, "y" : 354 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 939, "y" : 352 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 939, "y" : 352 } } }, "connectors" : [ { "edgeId" : 132750, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132759, "reactomeId" : 10356685, "displayName" : "CXCR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1273, "y" : 367 }, "minX" : 1246, "maxX" : 1314, "minY" : 347, "maxY" : 405, "prop" : { "x" : 1246, "y" : 353, "width" : 55, "height" : 29 }, "textPosition" : { "x" : 1250, "y" : 357 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1301, "y" : 353 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1301, "y" : 353 } } }, "connectors" : [ { "edgeId" : 132758, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1288, "y" : 385 }, "to" : { "x" : 1314, "y" : 405 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132756, "reactomeId" : 10356679, "displayName" : "CXCR1 ligands", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1022, "y" : 424 }, "minX" : 991, "maxX" : 1072, "minY" : 401, "maxY" : 440, "prop" : { "x" : 991, "y" : 409, "width" : 62, "height" : 31 }, "textPosition" : { "x" : 995, "y" : 407 }, "connectors" : [ { "edgeId" : 132754, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1059, "y" : 409 }, "to" : { "x" : 1072, "y" : 401 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132757, "reactomeId" : 10356681, "displayName" : "CXCR1:CXCR1 ligands", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1164, "y" : 367 }, "minX" : 1116, "maxX" : 1218, "minY" : 342, "maxY" : 386, "prop" : { "x" : 1116, "y" : 348, "width" : 96, "height" : 38 }, "textPosition" : { "x" : 1117, "y" : 351 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1212, "y" : 348 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1212, "y" : 348 } } }, "connectors" : [ { "edgeId" : 132754, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132763, "reactomeId" : 10356754, "displayName" : "CXCR3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1474, "y" : 369 }, "minX" : 1450, "maxX" : 1524, "minY" : 352, "maxY" : 395, "prop" : { "x" : 1450, "y" : 358, "width" : 49, "height" : 22 }, "textPosition" : { "x" : 1451, "y" : 358 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1499, "y" : 358 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1499, "y" : 358 } } }, "connectors" : [ { "edgeId" : 132762, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1495, "y" : 383 }, "to" : { "x" : 1524, "y" : 395 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132760, "reactomeId" : 10356707, "displayName" : "CXCR2 ligands", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1268, "y" : 441 }, "minX" : 1240, "maxX" : 1314, "minY" : 405, "maxY" : 457, "prop" : { "x" : 1240, "y" : 425, "width" : 57, "height" : 32 }, "textPosition" : { "x" : 1242, "y" : 424 }, "connectors" : [ { "edgeId" : 132758, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1288, "y" : 419 }, "to" : { "x" : 1314, "y" : 405 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132761, "reactomeId" : 10356709, "displayName" : "CXCR2:CXCR2 ligands", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1387, "y" : 367 }, "minX" : 1339, "maxX" : 1441, "minY" : 342, "maxY" : 386, "prop" : { "x" : 1339, "y" : 348, "width" : 96, "height" : 38 }, "textPosition" : { "x" : 1340, "y" : 351 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1435, "y" : 348 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1435, "y" : 348 } } }, "connectors" : [ { "edgeId" : 132758, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132767, "reactomeId" : 10356484, "displayName" : "CXCR6", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1713, "y" : 369 }, "minX" : 1688, "maxX" : 1754, "minY" : 346, "maxY" : 396, "prop" : { "x" : 1688, "y" : 352, "width" : 50, "height" : 35 }, "textPosition" : { "x" : 1689, "y" : 359 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1738, "y" : 352 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1738, "y" : 352 } } }, "connectors" : [ { "edgeId" : 132766, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1741, "y" : 385 }, "to" : { "x" : 1754, "y" : 396 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132764, "reactomeId" : 10356750, "displayName" : "CXCR3 ligands", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1480, "y" : 424 }, "minX" : 1434, "maxX" : 1527, "minY" : 395, "maxY" : 436, "prop" : { "x" : 1434, "y" : 413, "width" : 93, "height" : 23 }, "textPosition" : { "x" : 1454, "y" : 407 }, "connectors" : [ { "edgeId" : 132762, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1497, "y" : 407 }, "to" : { "x" : 1524, "y" : 395 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132765, "reactomeId" : 10356756, "displayName" : "CXCR3:CXCR3 ligands", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1622, "y" : 369 }, "minX" : 1574, "maxX" : 1676, "minY" : 344, "maxY" : 388, "prop" : { "x" : 1574, "y" : 350, "width" : 96, "height" : 38 }, "textPosition" : { "x" : 1575, "y" : 353 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1670, "y" : 350 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1670, "y" : 350 } } }, "connectors" : [ { "edgeId" : 132762, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132771, "reactomeId" : 10356356, "displayName" : "CCR1,2,8", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2307, "y" : 372 }, "minX" : 2272, "maxX" : 2350, "minY" : 357, "maxY" : 410, "prop" : { "x" : 2272, "y" : 357, "width" : 70, "height" : 30 }, "textPosition" : { "x" : 2275, "y" : 361 }, "connectors" : [ { "edgeId" : 132770, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2323, "y" : 393 }, "to" : { "x" : 2350, "y" : 410 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132768, "reactomeId" : 10356488, "displayName" : "CXCL16", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1716, "y" : 420 }, "minX" : 1689, "maxX" : 1754, "minY" : 396, "maxY" : 432, "prop" : { "x" : 1689, "y" : 409, "width" : 54, "height" : 23 }, "textPosition" : { "x" : 1689, "y" : 410 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1743, "y" : 409 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1743, "y" : 409 } } }, "connectors" : [ { "edgeId" : 132766, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1734, "y" : 406 }, "to" : { "x" : 1754, "y" : 396 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132769, "reactomeId" : 10356490, "displayName" : "CXCR6:CXCL16", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1835, "y" : 367 }, "minX" : 1805, "maxX" : 1872, "minY" : 342, "maxY" : 387, "prop" : { "x" : 1805, "y" : 348, "width" : 61, "height" : 39 }, "textPosition" : { "x" : 1809, "y" : 352 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1866, "y" : 348 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1866, "y" : 348 } } }, "connectors" : [ { "edgeId" : 132766, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132775, "reactomeId" : 10356320, "displayName" : "CCR3,4,5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2716, "y" : 368 }, "minX" : 2683, "maxX" : 2750, "minY" : 357, "maxY" : 399, "prop" : { "x" : 2683, "y" : 357, "width" : 67, "height" : 23 }, "textPosition" : { "x" : 2684, "y" : 358 }, "connectors" : [ { "edgeId" : 132774, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2726, "y" : 386 }, "to" : { "x" : 2745, "y" : 399 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132772, "reactomeId" : 10356360, "displayName" : "CCL16", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2309, "y" : 433 }, "minX" : 2285, "maxX" : 2350, "minY" : 410, "maxY" : 448, "prop" : { "x" : 2285, "y" : 418, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 2286, "y" : 422 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2333, "y" : 418 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2333, "y" : 418 } } }, "connectors" : [ { "edgeId" : 132770, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2336, "y" : 419 }, "to" : { "x" : 2350, "y" : 410 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132773, "reactomeId" : 10356362, "displayName" : "CCR1,2,8:CCL16", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2433, "y" : 369 }, "minX" : 2397, "maxX" : 2475, "minY" : 343, "maxY" : 389, "prop" : { "x" : 2397, "y" : 349, "width" : 72, "height" : 40 }, "textPosition" : { "x" : 2399, "y" : 354 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2469, "y" : 349 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2469, "y" : 349 } } }, "connectors" : [ { "edgeId" : 132770, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132779, "reactomeId" : 10365063, "displayName" : "CCBP2 ligands", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 573, "y" : 515 }, "minX" : 543, "maxX" : 604, "minY" : 500, "maxY" : 550, "prop" : { "x" : 543, "y" : 500, "width" : 61, "height" : 30 }, "textPosition" : { "x" : 547, "y" : 498 }, "connectors" : [ { "edgeId" : 132778, "type" : "INPUT", "segments" : [ { "from" : { "x" : 579, "y" : 536 }, "to" : { "x" : 587, "y" : 550 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132776, "reactomeId" : 10356306, "displayName" : "CCL5", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2709, "y" : 432 }, "minX" : 2679, "maxX" : 2746, "minY" : 399, "maxY" : 448, "prop" : { "x" : 2679, "y" : 416, "width" : 61, "height" : 32 }, "textPosition" : { "x" : 2690, "y" : 421 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2740, "y" : 416 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2740, "y" : 416 } } }, "connectors" : [ { "edgeId" : 132774, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2726, "y" : 413 }, "to" : { "x" : 2745, "y" : 399 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132777, "reactomeId" : 10356322, "displayName" : "CCR3,4,5:CCL5(24-91)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2825, "y" : 368 }, "minX" : 2783, "maxX" : 2874, "minY" : 343, "maxY" : 388, "prop" : { "x" : 2783, "y" : 349, "width" : 85, "height" : 39 }, "textPosition" : { "x" : 2783, "y" : 353 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2868, "y" : 349 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2868, "y" : 349 } } }, "connectors" : [ { "edgeId" : 132774, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132783, "reactomeId" : 10365023, "displayName" : "CCL19, CCL21, CCL25", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3862, "y" : 33 }, "minX" : 3829, "maxX" : 3909, "minY" : 9, "maxY" : 62, "prop" : { "x" : 3829, "y" : 9, "width" : 66, "height" : 48 }, "textPosition" : { "x" : 3835, "y" : 9 }, "connectors" : [ { "edgeId" : 132782, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3901, "y" : 53 }, "to" : { "x" : 3909, "y" : 62 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132780, "reactomeId" : 10365031, "displayName" : "ACKR2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 563, "y" : 580 }, "minX" : 539, "maxX" : 594, "minY" : 550, "maxY" : 592, "prop" : { "x" : 539, "y" : 569, "width" : 49, "height" : 23 }, "textPosition" : { "x" : 540, "y" : 570 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 588, "y" : 569 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 588, "y" : 569 } } }, "connectors" : [ { "edgeId" : 132778, "type" : "INPUT", "segments" : [ { "from" : { "x" : 572, "y" : 566 }, "to" : { "x" : 587, "y" : 550 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132781, "reactomeId" : 10365065, "displayName" : "ACKR2:CCBP2 ligands", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 677, "y" : 580 }, "minX" : 629, "maxX" : 731, "minY" : 555, "maxY" : 599, "prop" : { "x" : 629, "y" : 561, "width" : 96, "height" : 38 }, "textPosition" : { "x" : 629, "y" : 564 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 725, "y" : 561 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 725, "y" : 561 } } }, "connectors" : [ { "edgeId" : 132778, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132787, "reactomeId" : 10358581, "displayName" : "CXCL13", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3652, "y" : 419 }, "minX" : 3625, "maxX" : 3690, "minY" : 396, "maxY" : 431, "prop" : { "x" : 3625, "y" : 408, "width" : 54, "height" : 23 }, "textPosition" : { "x" : 3625, "y" : 409 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3679, "y" : 408 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3679, "y" : 408 } } }, "connectors" : [ { "edgeId" : 132786, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3671, "y" : 405 }, "to" : { "x" : 3690, "y" : 396 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132784, "reactomeId" : 10365021, "displayName" : "ACKR4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3864, "y" : 87 }, "minX" : 3840, "maxX" : 3909, "minY" : 62, "maxY" : 99, "prop" : { "x" : 3840, "y" : 76, "width" : 49, "height" : 23 }, "textPosition" : { "x" : 3841, "y" : 77 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3889, "y" : 76 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3889, "y" : 76 } } }, "connectors" : [ { "edgeId" : 132782, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3884, "y" : 73 }, "to" : { "x" : 3909, "y" : 62 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132785, "reactomeId" : 10365025, "displayName" : "CCR11:CCL19,21,25", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4000, "y" : 88 }, "minX" : 3964, "maxX" : 4043, "minY" : 54, "maxY" : 116, "prop" : { "x" : 3964, "y" : 60, "width" : 73, "height" : 56 }, "textPosition" : { "x" : 3974, "y" : 67 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4037, "y" : 60 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4037, "y" : 60 } } }, "connectors" : [ { "edgeId" : 132782, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132791, "reactomeId" : 10356889, "displayName" : "Somatostatin, cortistatin", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2985, "y" : 23 }, "minX" : 2940, "maxX" : 3035, "minY" : 5, "maxY" : 70, "prop" : { "x" : 2940, "y" : 5, "width" : 90, "height" : 36 }, "textPosition" : { "x" : 2941, "y" : 5 }, "connectors" : [ { "edgeId" : 132790, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3004, "y" : 47 }, "to" : { "x" : 3035, "y" : 70 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132788, "reactomeId" : 10358577, "displayName" : "CXCR5", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3649, "y" : 373 }, "minX" : 3621, "maxX" : 3690, "minY" : 352, "maxY" : 396, "prop" : { "x" : 3621, "y" : 358, "width" : 56, "height" : 30 }, "textPosition" : { "x" : 3625, "y" : 362 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3677, "y" : 358 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3677, "y" : 358 } } }, "connectors" : [ { "edgeId" : 132786, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3675, "y" : 391 }, "to" : { "x" : 3690, "y" : 396 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132789, "reactomeId" : 10358583, "displayName" : "CXCR5:CXCL13", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3772, "y" : 371 }, "minX" : 3734, "maxX" : 3816, "minY" : 347, "maxY" : 389, "prop" : { "x" : 3734, "y" : 353, "width" : 76, "height" : 36 }, "textPosition" : { "x" : 3745, "y" : 354 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3810, "y" : 353 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3810, "y" : 353 } } }, "connectors" : [ { "edgeId" : 132786, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132795, "reactomeId" : 10358228, "displayName" : "TAC1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 569, "y" : 429 }, "minX" : 524, "maxX" : 621, "minY" : 399, "maxY" : 446, "prop" : { "x" : 524, "y" : 412, "width" : 91, "height" : 34 }, "textPosition" : { "x" : 550, "y" : 418 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 615, "y" : 412 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 615, "y" : 412 } } }, "connectors" : [ { "edgeId" : 132794, "type" : "INPUT", "segments" : [ { "from" : { "x" : 587, "y" : 409 }, "to" : { "x" : 602, "y" : 399 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132792, "reactomeId" : 10356907, "displayName" : "Somatostatin receptors", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2957, "y" : 86 }, "minX" : 2915, "maxX" : 3035, "minY" : 67, "maxY" : 105, "prop" : { "x" : 2915, "y" : 67, "width" : 84, "height" : 38 }, "textPosition" : { "x" : 2915, "y" : 68 }, "connectors" : [ { "edgeId" : 132790, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3005, "y" : 77 }, "to" : { "x" : 3035, "y" : 70 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132793, "reactomeId" : 10356909, "displayName" : "Somatostatin receptor:somatostatin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3117, "y" : 78 }, "minX" : 3069, "maxX" : 3171, "minY" : 45, "maxY" : 105, "prop" : { "x" : 3069, "y" : 51, "width" : 96, "height" : 54 }, "textPosition" : { "x" : 3069, "y" : 56 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3165, "y" : 51 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3165, "y" : 51 } } }, "connectors" : [ { "edgeId" : 132790, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132799, "reactomeId" : 10358236, "displayName" : "TAC1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 199, "y" : 31 }, "minX" : 146, "maxX" : 258, "minY" : 11, "maxY" : 89, "prop" : { "x" : 146, "y" : 17, "width" : 106, "height" : 28 }, "textPosition" : { "x" : 179, "y" : 20 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 252, "y" : 17 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 252, "y" : 17 } } }, "connectors" : [ { "edgeId" : 132798, "type" : "INPUT", "segments" : [ { "from" : { "x" : 188, "y" : 48 }, "to" : { "x" : 156, "y" : 89 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132796, "reactomeId" : 10358232, "displayName" : "TACR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 568, "y" : 369 }, "minX" : 541, "maxX" : 602, "minY" : 347, "maxY" : 399, "prop" : { "x" : 541, "y" : 353, "width" : 55, "height" : 32 }, "textPosition" : { "x" : 545, "y" : 358 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 596, "y" : 353 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 596, "y" : 353 } } }, "connectors" : [ { "edgeId" : 132794, "type" : "INPUT", "segments" : [ { "from" : { "x" : 586, "y" : 388 }, "to" : { "x" : 602, "y" : 399 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132797, "reactomeId" : 10358234, "displayName" : "TACR1:TAC1(58-68)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 666, "y" : 365 }, "minX" : 622, "maxX" : 716, "minY" : 339, "maxY" : 385, "prop" : { "x" : 622, "y" : 345, "width" : 88, "height" : 40 }, "textPosition" : { "x" : 625, "y" : 350 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 710, "y" : 345 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 710, "y" : 345 } } }, "connectors" : [ { "edgeId" : 132794, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132803, "reactomeId" : 10358246, "displayName" : "TAC3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2337, "y" : 585 }, "minX" : 2313, "maxX" : 2368, "minY" : 561, "maxY" : 599, "prop" : { "x" : 2313, "y" : 571, "width" : 49, "height" : 28 }, "textPosition" : { "x" : 2318, "y" : 574 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2362, "y" : 571 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2362, "y" : 571 } } }, "connectors" : [ { "edgeId" : 132802, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2353, "y" : 568 }, "to" : { "x" : 2366, "y" : 561 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132800, "reactomeId" : 10358240, "displayName" : "TACR2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 216, "y" : 89 }, "minX" : 156, "maxX" : 256, "minY" : 69, "maxY" : 103, "prop" : { "x" : 183, "y" : 75, "width" : 67, "height" : 28 }, "textPosition" : { "x" : 193, "y" : 78 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 250, "y" : 75 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 250, "y" : 75 } } }, "connectors" : [ { "edgeId" : 132798, "type" : "INPUT", "segments" : [ { "from" : { "x" : 180, "y" : 89 }, "to" : { "x" : 156, "y" : 89 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132801, "reactomeId" : 10358242, "displayName" : "TACR2:TAC1(98-107)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 198, "y" : 167 }, "minX" : 146, "maxX" : 256, "minY" : 141, "maxY" : 187, "prop" : { "x" : 146, "y" : 147, "width" : 104, "height" : 40 }, "textPosition" : { "x" : 157, "y" : 152 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 250, "y" : 147 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 250, "y" : 147 } } }, "connectors" : [ { "edgeId" : 132798, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132807, "reactomeId" : 10358066, "displayName" : "AVPR1A,B", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 174, "y" : 2518 }, "minX" : 97, "maxX" : 210, "minY" : 2478, "maxY" : 2582, "prop" : { "x" : 138, "y" : 2503, "width" : 72, "height" : 30 }, "textPosition" : { "x" : 140, "y" : 2507 }, "connectors" : [ { "edgeId" : 133247, "type" : "INPUT", "segments" : [ { "from" : { "x" : 153, "y" : 2497 }, "to" : { "x" : 118, "y" : 2478 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 132806, "type" : "INPUT", "segments" : [ { "from" : { "x" : 155, "y" : 2539 }, "to" : { "x" : 97, "y" : 2582 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132804, "reactomeId" : 10358250, "displayName" : "TACR3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2335, "y" : 533 }, "minX" : 2309, "maxX" : 2367, "minY" : 509, "maxY" : 561, "prop" : { "x" : 2309, "y" : 515, "width" : 52, "height" : 36 }, "textPosition" : { "x" : 2311, "y" : 522 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2361, "y" : 515 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2361, "y" : 515 } } }, "connectors" : [ { "edgeId" : 132802, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2354, "y" : 554 }, "to" : { "x" : 2366, "y" : 561 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132805, "reactomeId" : 10358252, "displayName" : "TACR3:TAC3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2454, "y" : 578 }, "minX" : 2407, "maxX" : 2507, "minY" : 560, "maxY" : 590, "prop" : { "x" : 2407, "y" : 566, "width" : 94, "height" : 24 }, "textPosition" : { "x" : 2413, "y" : 569 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2501, "y" : 566 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2501, "y" : 566 } } }, "connectors" : [ { "edgeId" : 132802, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132811, "reactomeId" : 10357626, "displayName" : "AVP", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 207, "y" : 2765 }, "minX" : 164, "maxX" : 281, "minY" : 2744, "maxY" : 2778, "prop" : { "x" : 164, "y" : 2752, "width" : 87, "height" : 26 }, "textPosition" : { "x" : 191, "y" : 2754 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 251, "y" : 2752 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 251, "y" : 2752 } } }, "connectors" : [ { "edgeId" : 132810, "type" : "INPUT", "segments" : [ { "from" : { "x" : 254, "y" : 2752 }, "to" : { "x" : 281, "y" : 2744 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132808, "reactomeId" : 10357626, "displayName" : "AVP", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 76, "y" : 2541 }, "minX" : 33, "maxX" : 126, "minY" : 2522, "maxY" : 2582, "prop" : { "x" : 33, "y" : 2528, "width" : 87, "height" : 26 }, "textPosition" : { "x" : 60, "y" : 2530 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 120, "y" : 2528 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 120, "y" : 2528 } } }, "connectors" : [ { "edgeId" : 132806, "type" : "INPUT", "segments" : [ { "from" : { "x" : 82, "y" : 2557 }, "to" : { "x" : 97, "y" : 2582 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132809, "reactomeId" : 10358068, "displayName" : "AVPR1A,B:AVP(20-28)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 178, "y" : 2604 }, "minX" : 131, "maxX" : 231, "minY" : 2579, "maxY" : 2624, "prop" : { "x" : 131, "y" : 2585, "width" : 94, "height" : 39 }, "textPosition" : { "x" : 139, "y" : 2589 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 225, "y" : 2585 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 225, "y" : 2585 } } }, "connectors" : [ { "edgeId" : 132806, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132815, "reactomeId" : 10358310, "displayName" : "OXTR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1183, "y" : 584 }, "minX" : 1162, "maxX" : 1210, "minY" : 558, "maxY" : 596, "prop" : { "x" : 1162, "y" : 572, "width" : 42, "height" : 24 }, "textPosition" : { "x" : 1163, "y" : 573 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1204, "y" : 572 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1204, "y" : 572 } } }, "connectors" : [ { "edgeId" : 132814, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1194, "y" : 569 }, "to" : { "x" : 1208, "y" : 558 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132812, "reactomeId" : 10357630, "displayName" : "AVPR2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 211, "y" : 2700 }, "minX" : 63, "maxX" : 281, "minY" : 2679, "maxY" : 2744, "prop" : { "x" : 187, "y" : 2685, "width" : 49, "height" : 31 }, "textPosition" : { "x" : 187, "y" : 2690 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 236, "y" : 2685 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 236, "y" : 2685 } } }, "connectors" : [ { "edgeId" : 133250, "type" : "INPUT", "segments" : [ { "from" : { "x" : 184, "y" : 2696 }, "to" : { "x" : 63, "y" : 2680 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 132810, "type" : "INPUT", "segments" : [ { "from" : { "x" : 239, "y" : 2715 }, "to" : { "x" : 281, "y" : 2744 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132813, "reactomeId" : 10357632, "displayName" : "AVPR2:AVP(20-28)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 393, "y" : 2706 }, "minX" : 346, "maxX" : 446, "minY" : 2682, "maxY" : 2724, "prop" : { "x" : 346, "y" : 2688, "width" : 94, "height" : 36 }, "textPosition" : { "x" : 355, "y" : 2689 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 440, "y" : 2688 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 440, "y" : 2688 } } }, "connectors" : [ { "edgeId" : 132810, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132819, "reactomeId" : 10358148, "displayName" : "CCKAR,CCKBR", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1399, "y" : 585 }, "minX" : 1350, "maxX" : 1448, "minY" : 547, "maxY" : 604, "prop" : { "x" : 1350, "y" : 566, "width" : 98, "height" : 38 }, "textPosition" : { "x" : 1354, "y" : 574 }, "connectors" : [ { "edgeId" : 132818, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1419, "y" : 560 }, "to" : { "x" : 1439, "y" : 547 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132816, "reactomeId" : 10358306, "displayName" : "OXT", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1180, "y" : 529 }, "minX" : 1138, "maxX" : 1228, "minY" : 511, "maxY" : 558, "prop" : { "x" : 1138, "y" : 517, "width" : 84, "height" : 25 }, "textPosition" : { "x" : 1164, "y" : 519 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1222, "y" : 517 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1222, "y" : 517 } } }, "connectors" : [ { "edgeId" : 132814, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1192, "y" : 545 }, "to" : { "x" : 1208, "y" : 558 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132817, "reactomeId" : 10358312, "displayName" : "OXTR:OXT(20-28)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1285, "y" : 583 }, "minX" : 1247, "maxX" : 1330, "minY" : 558, "maxY" : 603, "prop" : { "x" : 1247, "y" : 564, "width" : 77, "height" : 39 }, "textPosition" : { "x" : 1252, "y" : 568 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1324, "y" : 564 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1324, "y" : 564 } } }, "connectors" : [ { "edgeId" : 132814, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132823, "reactomeId" : 10358164, "displayName" : "EDNs", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1944, "y" : 2372 }, "minX" : 1919, "maxX" : 2117, "minY" : 2361, "maxY" : 2423, "prop" : { "x" : 1919, "y" : 2361, "width" : 51, "height" : 23 }, "textPosition" : { "x" : 1924, "y" : 2362 }, "connectors" : [ { "edgeId" : 133317, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1976, "y" : 2377 }, "to" : { "x" : 2117, "y" : 2409 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 132822, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1944, "y" : 2390 }, "to" : { "x" : 1944, "y" : 2423 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132820, "reactomeId" : 10358138, "displayName" : "CCK", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1397, "y" : 528 }, "minX" : 1380, "maxX" : 1439, "minY" : 511, "maxY" : 547, "prop" : { "x" : 1380, "y" : 517, "width" : 34, "height" : 23 }, "textPosition" : { "x" : 1381, "y" : 518 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1414, "y" : 517 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1414, "y" : 517 } } }, "connectors" : [ { "edgeId" : 132818, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1417, "y" : 535 }, "to" : { "x" : 1439, "y" : 547 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132821, "reactomeId" : 10358150, "displayName" : "CCKAR,CCKBR:CCK", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1513, "y" : 584 }, "minX" : 1466, "maxX" : 1567, "minY" : 560, "maxY" : 603, "prop" : { "x" : 1466, "y" : 566, "width" : 95, "height" : 37 }, "textPosition" : { "x" : 1466, "y" : 568 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1561, "y" : 566 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1561, "y" : 566 } } }, "connectors" : [ { "edgeId" : 132818, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132827, "reactomeId" : 10357863, "displayName" : "Melanocortin receptors", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 199, "y" : 906 }, "minX" : 158, "maxX" : 241, "minY" : 890, "maxY" : 946, "prop" : { "x" : 158, "y" : 890, "width" : 83, "height" : 33 }, "textPosition" : { "x" : 159, "y" : 889 }, "connectors" : [ { "edgeId" : 132826, "type" : "INPUT", "segments" : [ { "from" : { "x" : 202, "y" : 929 }, "to" : { "x" : 208, "y" : 946 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132824, "reactomeId" : 10358174, "displayName" : "EDNRA,EDNRB", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1911, "y" : 2481 }, "minX" : 1821, "maxX" : 1946, "minY" : 2415, "maxY" : 2497, "prop" : { "x" : 1876, "y" : 2465, "width" : 70, "height" : 32 }, "textPosition" : { "x" : 1884, "y" : 2464 }, "connectors" : [ { "edgeId" : 133314, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1889, "y" : 2459 }, "to" : { "x" : 1821, "y" : 2415 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 132822, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1920, "y" : 2459 }, "to" : { "x" : 1944, "y" : 2423 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132825, "reactomeId" : 10358176, "displayName" : "EDNRA,EDNRB:EDNs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2004, "y" : 2483 }, "minX" : 1973, "maxX" : 2041, "minY" : 2453, "maxY" : 2508, "prop" : { "x" : 1973, "y" : 2459, "width" : 62, "height" : 49 }, "textPosition" : { "x" : 1977, "y" : 2459 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2035, "y" : 2459 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2035, "y" : 2459 } } }, "connectors" : [ { "edgeId" : 132822, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132831, "reactomeId" : 10357837, "displayName" : "MC2R", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 189, "y" : 578 }, "minX" : 165, "maxX" : 220, "minY" : 547, "maxY" : 590, "prop" : { "x" : 165, "y" : 567, "width" : 49, "height" : 23 }, "textPosition" : { "x" : 168, "y" : 568 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 214, "y" : 567 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 214, "y" : 567 } } }, "connectors" : [ { "edgeId" : 132830, "type" : "INPUT", "segments" : [ { "from" : { "x" : 194, "y" : 564 }, "to" : { "x" : 204, "y" : 547 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132828, "reactomeId" : 10357841, "displayName" : "POMC", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 178, "y" : 970 }, "minX" : 157, "maxX" : 208, "minY" : 946, "maxY" : 982, "prop" : { "x" : 157, "y" : 959, "width" : 43, "height" : 23 }, "textPosition" : { "x" : 157, "y" : 960 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 200, "y" : 959 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 200, "y" : 959 } } }, "connectors" : [ { "edgeId" : 132826, "type" : "INPUT", "segments" : [ { "from" : { "x" : 192, "y" : 953 }, "to" : { "x" : 208, "y" : 946 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132829, "reactomeId" : 10357865, "displayName" : "MSH:Melanocortin receptors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 312, "y" : 909 }, "minX" : 257, "maxX" : 373, "minY" : 884, "maxY" : 928, "prop" : { "x" : 257, "y" : 890, "width" : 110, "height" : 38 }, "textPosition" : { "x" : 265, "y" : 879 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 367, "y" : 890 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 367, "y" : 890 } } }, "connectors" : [ { "edgeId" : 132826, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132835, "reactomeId" : 10360391, "displayName" : "PRLH peptides", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3629, "y" : 512 }, "minX" : 3575, "maxX" : 3683, "minY" : 499, "maxY" : 548, "prop" : { "x" : 3575, "y" : 499, "width" : 108, "height" : 26 }, "textPosition" : { "x" : 3580, "y" : 501 }, "connectors" : [ { "edgeId" : 132834, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3640, "y" : 531 }, "to" : { "x" : 3661, "y" : 548 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132832, "reactomeId" : 10357833, "displayName" : "POMC", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 200, "y" : 518 }, "minX" : 146, "maxX" : 261, "minY" : 499, "maxY" : 547, "prop" : { "x" : 146, "y" : 505, "width" : 109, "height" : 27 }, "textPosition" : { "x" : 179, "y" : 508 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 255, "y" : 505 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 255, "y" : 505 } } }, "connectors" : [ { "edgeId" : 132830, "type" : "INPUT", "segments" : [ { "from" : { "x" : 201, "y" : 535 }, "to" : { "x" : 204, "y" : 547 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132833, "reactomeId" : 10357839, "displayName" : "POMC(138-176):MC2R", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 283, "y" : 580 }, "minX" : 239, "maxX" : 334, "minY" : 554, "maxY" : 600, "prop" : { "x" : 239, "y" : 560, "width" : 89, "height" : 40 }, "textPosition" : { "x" : 245, "y" : 565 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 328, "y" : 560 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 328, "y" : 560 } } }, "connectors" : [ { "edgeId" : 132830, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132839, "reactomeId" : 10358759, "displayName" : "Neuropeptide Y receptors", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3844, "y" : 576 }, "minX" : 3796, "maxX" : 3903, "minY" : 540, "maxY" : 595, "prop" : { "x" : 3796, "y" : 557, "width" : 96, "height" : 38 }, "textPosition" : { "x" : 3795, "y" : 558 }, "connectors" : [ { "edgeId" : 132838, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3875, "y" : 551 }, "to" : { "x" : 3903, "y" : 540 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132836, "reactomeId" : 10360383, "displayName" : "PRLHR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3631, "y" : 575 }, "minX" : 3607, "maxX" : 3661, "minY" : 548, "maxY" : 587, "prop" : { "x" : 3607, "y" : 564, "width" : 48, "height" : 23 }, "textPosition" : { "x" : 3607, "y" : 565 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3655, "y" : 564 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3655, "y" : 564 } } }, "connectors" : [ { "edgeId" : 132834, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3643, "y" : 561 }, "to" : { "x" : 3661, "y" : 548 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132837, "reactomeId" : 10360393, "displayName" : "PRLHR:PRLH peptides", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3740, "y" : 569 }, "minX" : 3708, "maxX" : 3778, "minY" : 537, "maxY" : 595, "prop" : { "x" : 3708, "y" : 543, "width" : 64, "height" : 52 }, "textPosition" : { "x" : 3708, "y" : 546 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3772, "y" : 543 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3772, "y" : 543 } } }, "connectors" : [ { "edgeId" : 132834, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132843, "reactomeId" : 10358282, "displayName" : "NTSR1,NTSR2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1621, "y" : 583 }, "minX" : 1580, "maxX" : 1665, "minY" : 543, "maxY" : 598, "prop" : { "x" : 1580, "y" : 568, "width" : 83, "height" : 30 }, "textPosition" : { "x" : 1595, "y" : 566 }, "connectors" : [ { "edgeId" : 132842, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1637, "y" : 562 }, "to" : { "x" : 1665, "y" : 543 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132840, "reactomeId" : 10358741, "displayName" : "NPY receptor ligands", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3844, "y" : 505 }, "minX" : 3799, "maxX" : 3903, "minY" : 486, "maxY" : 540, "prop" : { "x" : 3799, "y" : 486, "width" : 90, "height" : 38 }, "textPosition" : { "x" : 3797, "y" : 487 }, "connectors" : [ { "edgeId" : 132838, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3876, "y" : 530 }, "to" : { "x" : 3903, "y" : 540 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132841, "reactomeId" : 10358761, "displayName" : "Neuropeptide Y receptors:NPY receptor ligands", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4001, "y" : 579 }, "minX" : 3956, "maxX" : 4053, "minY" : 540, "maxY" : 612, "prop" : { "x" : 3956, "y" : 546, "width" : 91, "height" : 66 }, "textPosition" : { "x" : 3955, "y" : 535 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4047, "y" : 546 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4047, "y" : 546 } } }, "connectors" : [ { "edgeId" : 132838, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132847, "reactomeId" : 10358691, "displayName" : "GAL", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3426, "y" : 519 }, "minX" : 3407, "maxX" : 3476, "minY" : 502, "maxY" : 545, "prop" : { "x" : 3407, "y" : 508, "width" : 39, "height" : 23 }, "textPosition" : { "x" : 3411, "y" : 509 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3446, "y" : 508 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3446, "y" : 508 } } }, "connectors" : [ { "edgeId" : 132846, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3449, "y" : 529 }, "to" : { "x" : 3476, "y" : 545 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132844, "reactomeId" : 10358272, "displayName" : "NTS", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1617, "y" : 510 }, "minX" : 1569, "maxX" : 1671, "minY" : 490, "maxY" : 543, "prop" : { "x" : 1569, "y" : 496, "width" : 96, "height" : 29 }, "textPosition" : { "x" : 1601, "y" : 500 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1665, "y" : 496 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1665, "y" : 496 } } }, "connectors" : [ { "edgeId" : 133191, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 132842, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1638, "y" : 528 }, "to" : { "x" : 1665, "y" : 543 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132845, "reactomeId" : 10358284, "displayName" : "NTSR1,NTSR2:NTS(151-163)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1756, "y" : 583 }, "minX" : 1709, "maxX" : 1809, "minY" : 557, "maxY" : 603, "prop" : { "x" : 1709, "y" : 563, "width" : 94, "height" : 40 }, "textPosition" : { "x" : 1718, "y" : 554 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1803, "y" : 563 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1803, "y" : 563 } } }, "connectors" : [ { "edgeId" : 132842, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132851, "reactomeId" : 10358186, "displayName" : "KISS1R", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2544, "y" : 577 }, "minX" : 2519, "maxX" : 2587, "minY" : 553, "maxY" : 589, "prop" : { "x" : 2519, "y" : 566, "width" : 51, "height" : 23 }, "textPosition" : { "x" : 2519, "y" : 567 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2570, "y" : 566 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2570, "y" : 566 } } }, "connectors" : [ { "edgeId" : 132850, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2564, "y" : 563 }, "to" : { "x" : 2587, "y" : 553 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132848, "reactomeId" : 10358705, "displayName" : "GALR1-3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3430, "y" : 578 }, "minX" : 3397, "maxX" : 3476, "minY" : 545, "maxY" : 593, "prop" : { "x" : 3397, "y" : 563, "width" : 67, "height" : 30 }, "textPosition" : { "x" : 3401, "y" : 567 }, "connectors" : [ { "edgeId" : 132846, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3450, "y" : 557 }, "to" : { "x" : 3476, "y" : 545 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132849, "reactomeId" : 10358707, "displayName" : "GALR1-3:GAL", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3545, "y" : 580 }, "minX" : 3496, "maxX" : 3600, "minY" : 561, "maxY" : 594, "prop" : { "x" : 3496, "y" : 567, "width" : 98, "height" : 27 }, "textPosition" : { "x" : 3502, "y" : 573 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3594, "y" : 567 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3594, "y" : 567 } } }, "connectors" : [ { "edgeId" : 132846, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132855, "reactomeId" : 10341689, "displayName" : "activated thrombin (factor IIa)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2761, "y" : 512 }, "minX" : 2725, "maxX" : 2806, "minY" : 481, "maxY" : 543, "prop" : { "x" : 2725, "y" : 487, "width" : 72, "height" : 51 }, "textPosition" : { "x" : 2726, "y" : 475 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2797, "y" : 487 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2797, "y" : 487 } } }, "connectors" : [ { "edgeId" : 132854, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2800, "y" : 536 }, "to" : { "x" : 2806, "y" : 543 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132852, "reactomeId" : 10358190, "displayName" : "KISS1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2545, "y" : 522 }, "minX" : 2513, "maxX" : 2587, "minY" : 497, "maxY" : 553, "prop" : { "x" : 2513, "y" : 503, "width" : 65, "height" : 39 }, "textPosition" : { "x" : 2524, "y" : 512 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2578, "y" : 503 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2578, "y" : 503 } } }, "connectors" : [ { "edgeId" : 132850, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2571, "y" : 545 }, "to" : { "x" : 2587, "y" : 553 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132853, "reactomeId" : 10358192, "displayName" : "KISS1R:KISS1(68-121)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2662, "y" : 573 }, "minX" : 2630, "maxX" : 2700, "minY" : 543, "maxY" : 598, "prop" : { "x" : 2630, "y" : 549, "width" : 64, "height" : 49 }, "textPosition" : { "x" : 2631, "y" : 549 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2694, "y" : 549 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2694, "y" : 549 } } }, "connectors" : [ { "edgeId" : 132850, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132859, "reactomeId" : 10358288, "displayName" : "HCRT", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2976, "y" : 533 }, "minX" : 2946, "maxX" : 3021, "minY" : 510, "maxY" : 558, "prop" : { "x" : 2946, "y" : 516, "width" : 60, "height" : 35 }, "textPosition" : { "x" : 2956, "y" : 523 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3006, "y" : 516 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3006, "y" : 516 } } }, "connectors" : [ { "edgeId" : 132858, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3009, "y" : 549 }, "to" : { "x" : 3021, "y" : 558 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132856, "reactomeId" : 10358322, "displayName" : "Proteinase-activated receptors", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2762, "y" : 581 }, "minX" : 2722, "maxX" : 2806, "minY" : 543, "maxY" : 608, "prop" : { "x" : 2722, "y" : 554, "width" : 81, "height" : 54 }, "textPosition" : { "x" : 2722, "y" : 556 }, "connectors" : [ { "edgeId" : 132854, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2793, "y" : 548 }, "to" : { "x" : 2806, "y" : 543 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132857, "reactomeId" : 10358324, "displayName" : "Thrombin:Proteinase-activated receptors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2888, "y" : 582 }, "minX" : 2848, "maxX" : 2935, "minY" : 542, "maxY" : 617, "prop" : { "x" : 2848, "y" : 548, "width" : 81, "height" : 69 }, "textPosition" : { "x" : 2848, "y" : 554 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2929, "y" : 548 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2929, "y" : 548 } } }, "connectors" : [ { "edgeId" : 132854, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132863, "reactomeId" : 10358300, "displayName" : "HCRTR2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3218, "y" : 582 }, "minX" : 3184, "maxX" : 3259, "minY" : 550, "maxY" : 598, "prop" : { "x" : 3184, "y" : 566, "width" : 69, "height" : 32 }, "textPosition" : { "x" : 3190, "y" : 571 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3253, "y" : 566 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3253, "y" : 566 } } }, "connectors" : [ { "edgeId" : 132862, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3238, "y" : 563 }, "to" : { "x" : 3259, "y" : 550 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132860, "reactomeId" : 10358292, "displayName" : "HCRTR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2977, "y" : 582 }, "minX" : 2943, "maxX" : 3021, "minY" : 558, "maxY" : 596, "prop" : { "x" : 2943, "y" : 568, "width" : 69, "height" : 28 }, "textPosition" : { "x" : 2949, "y" : 571 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3012, "y" : 568 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3012, "y" : 568 } } }, "connectors" : [ { "edgeId" : 132858, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3002, "y" : 565 }, "to" : { "x" : 3021, "y" : 558 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132861, "reactomeId" : 10358294, "displayName" : "HCRTR1:HCRT(34-66)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3114, "y" : 575 }, "minX" : 3068, "maxX" : 3167, "minY" : 549, "maxY" : 595, "prop" : { "x" : 3068, "y" : 555, "width" : 93, "height" : 40 }, "textPosition" : { "x" : 3068, "y" : 560 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3161, "y" : 555 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3161, "y" : 555 } } }, "connectors" : [ { "edgeId" : 132858, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132867, "reactomeId" : 10358266, "displayName" : "NPFFR1,NPFFR2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1920, "y" : 583 }, "minX" : 1870, "maxX" : 1971, "minY" : 545, "maxY" : 597, "prop" : { "x" : 1870, "y" : 570, "width" : 101, "height" : 27 }, "textPosition" : { "x" : 1891, "y" : 566 }, "connectors" : [ { "edgeId" : 132866, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1934, "y" : 564 }, "to" : { "x" : 1962, "y" : 545 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132864, "reactomeId" : 10358296, "displayName" : "HCRT", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3217, "y" : 515 }, "minX" : 3188, "maxX" : 3259, "minY" : 490, "maxY" : 550, "prop" : { "x" : 3188, "y" : 496, "width" : 59, "height" : 39 }, "textPosition" : { "x" : 3197, "y" : 505 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3247, "y" : 496 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3247, "y" : 496 } } }, "connectors" : [ { "edgeId" : 132862, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3240, "y" : 538 }, "to" : { "x" : 3259, "y" : 550 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132865, "reactomeId" : 10358302, "displayName" : "HCRTR2:HCRT(70-97)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3338, "y" : 578 }, "minX" : 3292, "maxX" : 3390, "minY" : 553, "maxY" : 597, "prop" : { "x" : 3292, "y" : 559, "width" : 92, "height" : 38 }, "textPosition" : { "x" : 3292, "y" : 562 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3384, "y" : 559 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3384, "y" : 559 } } }, "connectors" : [ { "edgeId" : 132862, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132871, "reactomeId" : 10358350, "displayName" : "QRFPR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2143, "y" : 579 }, "minX" : 2118, "maxX" : 2176, "minY" : 547, "maxY" : 595, "prop" : { "x" : 2118, "y" : 564, "width" : 51, "height" : 31 }, "textPosition" : { "x" : 2119, "y" : 569 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2169, "y" : 564 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2169, "y" : 564 } } }, "connectors" : [ { "edgeId" : 132870, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2158, "y" : 561 }, "to" : { "x" : 2176, "y" : 547 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132868, "reactomeId" : 10358256, "displayName" : "NPFF", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1917, "y" : 513 }, "minX" : 1872, "maxX" : 1969, "minY" : 492, "maxY" : 545, "prop" : { "x" : 1872, "y" : 498, "width" : 91, "height" : 31 }, "textPosition" : { "x" : 1898, "y" : 503 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1963, "y" : 498 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1963, "y" : 498 } } }, "connectors" : [ { "edgeId" : 132866, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1938, "y" : 532 }, "to" : { "x" : 1962, "y" : 545 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132869, "reactomeId" : 10358268, "displayName" : "NPFFR1,NPFFR2:NPFF(69-76)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2046, "y" : 580 }, "minX" : 1991, "maxX" : 2107, "minY" : 555, "maxY" : 599, "prop" : { "x" : 1991, "y" : 561, "width" : 110, "height" : 38 }, "textPosition" : { "x" : 1991, "y" : 564 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2101, "y" : 561 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2101, "y" : 561 } } }, "connectors" : [ { "edgeId" : 132866, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132875, "reactomeId" : 10358360, "displayName" : "MLNR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1238, "y" : 910 }, "minX" : 1215, "maxX" : 1267, "minY" : 891, "maxY" : 933, "prop" : { "x" : 1215, "y" : 897, "width" : 46, "height" : 27 }, "textPosition" : { "x" : 1217, "y" : 900 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1261, "y" : 897 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1261, "y" : 897 } } }, "connectors" : [ { "edgeId" : 132874, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1253, "y" : 927 }, "to" : { "x" : 1264, "y" : 933 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132872, "reactomeId" : 10358346, "displayName" : "QRFP", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2142, "y" : 520 }, "minX" : 2122, "maxX" : 2176, "minY" : 501, "maxY" : 547, "prop" : { "x" : 2122, "y" : 507, "width" : 41, "height" : 26 }, "textPosition" : { "x" : 2122, "y" : 509 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2163, "y" : 507 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2163, "y" : 507 } } }, "connectors" : [ { "edgeId" : 132870, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2158, "y" : 536 }, "to" : { "x" : 2176, "y" : 547 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132873, "reactomeId" : 10358352, "displayName" : "QRFPR:QRFP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2228, "y" : 579 }, "minX" : 2194, "maxX" : 2269, "minY" : 554, "maxY" : 598, "prop" : { "x" : 2194, "y" : 560, "width" : 69, "height" : 38 }, "textPosition" : { "x" : 2202, "y" : 563 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2263, "y" : 560 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2263, "y" : 560 } } }, "connectors" : [ { "edgeId" : 132870, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132879, "reactomeId" : 10358366, "displayName" : "TRHR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 761, "y" : 908 }, "minX" : 739, "maxX" : 793, "minY" : 888, "maxY" : 930, "prop" : { "x" : 739, "y" : 894, "width" : 45, "height" : 29 }, "textPosition" : { "x" : 741, "y" : 898 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 784, "y" : 894 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 784, "y" : 894 } } }, "connectors" : [ { "edgeId" : 132878, "type" : "INPUT", "segments" : [ { "from" : { "x" : 782, "y" : 926 }, "to" : { "x" : 793, "y" : 930 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132876, "reactomeId" : 10358356, "displayName" : "MLN", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1252, "y" : 966 }, "minX" : 1210, "maxX" : 1300, "minY" : 933, "maxY" : 980, "prop" : { "x" : 1210, "y" : 953, "width" : 84, "height" : 27 }, "textPosition" : { "x" : 1235, "y" : 956 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1294, "y" : 953 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1294, "y" : 953 } } }, "connectors" : [ { "edgeId" : 132874, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1256, "y" : 950 }, "to" : { "x" : 1264, "y" : 933 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132877, "reactomeId" : 10358362, "displayName" : "MLNR:MLN(24-47)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1341, "y" : 908 }, "minX" : 1304, "maxX" : 1385, "minY" : 883, "maxY" : 928, "prop" : { "x" : 1304, "y" : 889, "width" : 75, "height" : 39 }, "textPosition" : { "x" : 1306, "y" : 893 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1379, "y" : 889 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1379, "y" : 889 } } }, "connectors" : [ { "edgeId" : 132874, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132883, "reactomeId" : 10357893, "displayName" : "NPS", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 360, "y" : 530 }, "minX" : 339, "maxX" : 394, "minY" : 511, "maxY" : 551, "prop" : { "x" : 339, "y" : 517, "width" : 43, "height" : 27 }, "textPosition" : { "x" : 344, "y" : 520 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 382, "y" : 517 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 382, "y" : 517 } } }, "connectors" : [ { "edgeId" : 132882, "type" : "INPUT", "segments" : [ { "from" : { "x" : 385, "y" : 543 }, "to" : { "x" : 394, "y" : 551 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132880, "reactomeId" : 10358370, "displayName" : "TRH", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 760, "y" : 952 }, "minX" : 742, "maxX" : 793, "minY" : 929, "maxY" : 969, "prop" : { "x" : 742, "y" : 935, "width" : 37, "height" : 34 }, "textPosition" : { "x" : 744, "y" : 941 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 779, "y" : 935 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 779, "y" : 935 } } }, "connectors" : [ { "edgeId" : 132878, "type" : "INPUT", "segments" : [ { "from" : { "x" : 785, "y" : 939 }, "to" : { "x" : 793, "y" : 930 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132881, "reactomeId" : 10358382, "displayName" : "TRH:TRHR", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 855, "y" : 906 }, "minX" : 830, "maxX" : 887, "minY" : 882, "maxY" : 924, "prop" : { "x" : 830, "y" : 888, "width" : 51, "height" : 36 }, "textPosition" : { "x" : 835, "y" : 889 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 881, "y" : 888 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 881, "y" : 888 } } }, "connectors" : [ { "edgeId" : 132878, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132887, "reactomeId" : 10358396, "displayName" : "PROK1,PROK2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 962, "y" : 965 }, "minX" : 932, "maxX" : 1014, "minY" : 934, "maxY" : 982, "prop" : { "x" : 932, "y" : 948, "width" : 61, "height" : 34 }, "textPosition" : { "x" : 936, "y" : 948 }, "connectors" : [ { "edgeId" : 132886, "type" : "INPUT", "segments" : [ { "from" : { "x" : 990, "y" : 942 }, "to" : { "x" : 1014, "y" : 934 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132884, "reactomeId" : 10357897, "displayName" : "NPSR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 363, "y" : 576 }, "minX" : 337, "maxX" : 396, "minY" : 551, "maxY" : 590, "prop" : { "x" : 337, "y" : 563, "width" : 53, "height" : 27 }, "textPosition" : { "x" : 339, "y" : 566 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 390, "y" : 563 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 390, "y" : 563 } } }, "connectors" : [ { "edgeId" : 132882, "type" : "INPUT", "segments" : [ { "from" : { "x" : 379, "y" : 560 }, "to" : { "x" : 394, "y" : 551 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132885, "reactomeId" : 10357899, "displayName" : "NPSR1:NPS", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 463, "y" : 577 }, "minX" : 438, "maxX" : 495, "minY" : 552, "maxY" : 597, "prop" : { "x" : 438, "y" : 558, "width" : 51, "height" : 39 }, "textPosition" : { "x" : 439, "y" : 562 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 489, "y" : 558 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 489, "y" : 558 } } }, "connectors" : [ { "edgeId" : 132882, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132891, "reactomeId" : 10357911, "displayName" : "Relaxin-3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 390, "y" : 983 }, "minX" : 352, "maxX" : 435, "minY" : 945, "maxY" : 1001, "prop" : { "x" : 352, "y" : 966, "width" : 77, "height" : 35 }, "textPosition" : { "x" : 358, "y" : 973 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 429, "y" : 966 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 429, "y" : 966 } } }, "connectors" : [ { "edgeId" : 132890, "type" : "INPUT", "segments" : [ { "from" : { "x" : 401, "y" : 960 }, "to" : { "x" : 416, "y" : 945 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132888, "reactomeId" : 10358386, "displayName" : "PROKR2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 965, "y" : 909 }, "minX" : 935, "maxX" : 1014, "minY" : 883, "maxY" : 934, "prop" : { "x" : 935, "y" : 889, "width" : 60, "height" : 40 }, "textPosition" : { "x" : 937, "y" : 898 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 995, "y" : 889 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 995, "y" : 889 } } }, "connectors" : [ { "edgeId" : 132886, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1001, "y" : 924 }, "to" : { "x" : 1014, "y" : 934 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132889, "reactomeId" : 10358398, "displayName" : "PROKR1,PROKR2:PROK1,PROK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1108, "y" : 910 }, "minX" : 1050, "maxX" : 1173, "minY" : 884, "maxY" : 930, "prop" : { "x" : 1050, "y" : 890, "width" : 117, "height" : 40 }, "textPosition" : { "x" : 1052, "y" : 895 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1167, "y" : 890 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1167, "y" : 890 } } }, "connectors" : [ { "edgeId" : 132886, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132895, "reactomeId" : 10357917, "displayName" : "RXFP2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 578, "y" : 913 }, "minX" : 550, "maxX" : 613, "minY" : 896, "maxY" : 940, "prop" : { "x" : 550, "y" : 902, "width" : 57, "height" : 23 }, "textPosition" : { "x" : 555, "y" : 903 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 607, "y" : 902 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 607, "y" : 902 } } }, "connectors" : [ { "edgeId" : 132894, "type" : "INPUT", "segments" : [ { "from" : { "x" : 586, "y" : 928 }, "to" : { "x" : 598, "y" : 940 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132892, "reactomeId" : 10357903, "displayName" : "RXFP1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 405, "y" : 911 }, "minX" : 380, "maxX" : 437, "minY" : 890, "maxY" : 945, "prop" : { "x" : 380, "y" : 896, "width" : 51, "height" : 30 }, "textPosition" : { "x" : 382, "y" : 900 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 431, "y" : 896 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 431, "y" : 896 } } }, "connectors" : [ { "edgeId" : 132890, "type" : "INPUT", "segments" : [ { "from" : { "x" : 409, "y" : 929 }, "to" : { "x" : 416, "y" : 945 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132893, "reactomeId" : 10357913, "displayName" : "RXFP1:Relaxin-2,Relaxin-3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 484, "y" : 910 }, "minX" : 443, "maxX" : 532, "minY" : 880, "maxY" : 934, "prop" : { "x" : 443, "y" : 886, "width" : 83, "height" : 48 }, "textPosition" : { "x" : 450, "y" : 885 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 526, "y" : 886 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 526, "y" : 886 } } }, "connectors" : [ { "edgeId" : 132890, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132899, "reactomeId" : 10357911, "displayName" : "Relaxin-3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3639, "y" : 962 }, "minX" : 3604, "maxX" : 3682, "minY" : 932, "maxY" : 974, "prop" : { "x" : 3604, "y" : 950, "width" : 70, "height" : 24 }, "textPosition" : { "x" : 3607, "y" : 953 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3674, "y" : 950 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3674, "y" : 950 } } }, "connectors" : [ { "edgeId" : 132898, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3656, "y" : 947 }, "to" : { "x" : 3682, "y" : 932 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132896, "reactomeId" : 10357925, "displayName" : "Insulin-like peptide 3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 581, "y" : 980 }, "minX" : 545, "maxX" : 623, "minY" : 940, "maxY" : 1000, "prop" : { "x" : 545, "y" : 960, "width" : 72, "height" : 40 }, "textPosition" : { "x" : 547, "y" : 956 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 617, "y" : 960 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 617, "y" : 960 } } }, "connectors" : [ { "edgeId" : 132894, "type" : "INPUT", "segments" : [ { "from" : { "x" : 589, "y" : 954 }, "to" : { "x" : 598, "y" : 940 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132897, "reactomeId" : 10357927, "displayName" : "RXFP2:RXFP2 ligands", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 675, "y" : 912 }, "minX" : 631, "maxX" : 725, "minY" : 886, "maxY" : 933, "prop" : { "x" : 631, "y" : 892, "width" : 88, "height" : 41 }, "textPosition" : { "x" : 629, "y" : 898 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 719, "y" : 892 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 719, "y" : 892 } } }, "connectors" : [ { "edgeId" : 132894, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132903, "reactomeId" : 10358639, "displayName" : "CHRM2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3336, "y" : 2703 }, "minX" : 3300, "maxX" : 3374, "minY" : 2679, "maxY" : 2766, "prop" : { "x" : 3304, "y" : 2685, "width" : 64, "height" : 36 }, "textPosition" : { "x" : 3310, "y" : 2692 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3368, "y" : 2685 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3368, "y" : 2685 } } }, "connectors" : [ { "edgeId" : 132902, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3325, "y" : 2727 }, "to" : { "x" : 3300, "y" : 2766 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132900, "reactomeId" : 10358797, "displayName" : "RXFP3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3634, "y" : 913 }, "minX" : 3610, "maxX" : 3682, "minY" : 893, "maxY" : 932, "prop" : { "x" : 3610, "y" : 899, "width" : 48, "height" : 28 }, "textPosition" : { "x" : 3611, "y" : 902 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3658, "y" : 899 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3658, "y" : 899 } } }, "connectors" : [ { "edgeId" : 132898, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3661, "y" : 922 }, "to" : { "x" : 3682, "y" : 932 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132901, "reactomeId" : 10358799, "displayName" : "RXFP3:Relaxin-3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3772, "y" : 919 }, "minX" : 3732, "maxX" : 3818, "minY" : 895, "maxY" : 937, "prop" : { "x" : 3732, "y" : 901, "width" : 80, "height" : 36 }, "textPosition" : { "x" : 3740, "y" : 902 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3812, "y" : 901 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3812, "y" : 901 } } }, "connectors" : [ { "edgeId" : 132898, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132907, "reactomeId" : 372533, "displayName" : "AcCho", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 985, "y" : 2792 }, "minX" : 952, "maxX" : 1019, "minY" : 2751, "maxY" : 2808, "prop" : { "x" : 952, "y" : 2776, "width" : 66, "height" : 32 }, "textPosition" : { "x" : 961, "y" : 2781 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1013, "y" : 2781 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1013, "y" : 2781 } } }, "connectors" : [ { "edgeId" : 132906, "type" : "INPUT", "segments" : [ { "from" : { "x" : 985, "y" : 2773 }, "to" : { "x" : 985, "y" : 2751 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132904, "reactomeId" : 372533, "displayName" : "AcCho", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3300, "y" : 2813 }, "minX" : 3267, "maxX" : 3334, "minY" : 2766, "maxY" : 2829, "prop" : { "x" : 3267, "y" : 2797, "width" : 66, "height" : 32 }, "textPosition" : { "x" : 3276, "y" : 2802 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3328, "y" : 2802 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3328, "y" : 2802 } } }, "connectors" : [ { "edgeId" : 132902, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3300, "y" : 2794 }, "to" : { "x" : 3300, "y" : 2766 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132905, "reactomeId" : 10358641, "displayName" : "CHRM2,CHRM4:AcCho", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3247, "y" : 2704 }, "minX" : 3213, "maxX" : 3288, "minY" : 2673, "maxY" : 2729, "prop" : { "x" : 3213, "y" : 2679, "width" : 69, "height" : 50 }, "textPosition" : { "x" : 3220, "y" : 2680 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3282, "y" : 2679 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3282, "y" : 2679 } } }, "connectors" : [ { "edgeId" : 132902, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132911, "reactomeId" : 10358026, "displayName" : "ADRA1A,B,D", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1971, "y" : 908 }, "minX" : 1858, "maxX" : 2217, "minY" : 893, "maxY" : 1000, "prop" : { "x" : 1929, "y" : 893, "width" : 84, "height" : 30 }, "textPosition" : { "x" : 1930, "y" : 897 }, "connectors" : [ { "edgeId" : 132910, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2011, "y" : 929 }, "to" : { "x" : 2217, "y" : 1000 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133234, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1940, "y" : 929 }, "to" : { "x" : 1858, "y" : 964 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133236, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1971, "y" : 929 }, "to" : { "x" : 1971, "y" : 950 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132908, "reactomeId" : 10358010, "displayName" : "CHRM1,3,5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1032, "y" : 2702 }, "minX" : 985, "maxX" : 1109, "minY" : 2686, "maxY" : 2763, "prop" : { "x" : 1008, "y" : 2686, "width" : 48, "height" : 33 }, "textPosition" : { "x" : 1010, "y" : 2685 }, "connectors" : [ { "edgeId" : 132906, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1016, "y" : 2725 }, "to" : { "x" : 985, "y" : 2751 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133295, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1052, "y" : 2725 }, "to" : { "x" : 1109, "y" : 2763 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132909, "reactomeId" : 10358012, "displayName" : "CHRM1,3,5:AcCho", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 912, "y" : 2703 }, "minX" : 870, "maxX" : 960, "minY" : 2679, "maxY" : 2721, "prop" : { "x" : 870, "y" : 2685, "width" : 84, "height" : 36 }, "textPosition" : { "x" : 872, "y" : 2686 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 954, "y" : 2685 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 954, "y" : 2685 } } }, "connectors" : [ { "edgeId" : 132906, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132914, "reactomeId" : 10360911, "displayName" : "α1-agonists:ADRA1A,B,D", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 2105, "y" : 913 }, "minX" : 2063, "maxX" : 2208, "minY" : 889, "maxY" : 995, "prop" : { "x" : 2063, "y" : 895, "width" : 85, "height" : 36 }, "textPosition" : { "x" : 2064, "y" : 882 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2148, "y" : 895 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2148, "y" : 895 } } }, "connectors" : [ { "edgeId" : 132910, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 2127, "y" : 934 }, "to" : { "x" : 2208, "y" : 995 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2200, "y" : 994 }, "b" : { "x" : 2208, "y" : 995 }, "c" : { "x" : 2205, "y" : 988 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2205, "y" : 988 } } }, { "edgeId" : 133236, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132915, "reactomeId" : 10360909, "displayName" : "α1-antagonists:ADRA1A,B,D", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 1858, "y" : 912 }, "minX" : 1808, "maxX" : 2207, "minY" : 888, "maxY" : 1003, "prop" : { "x" : 1808, "y" : 894, "width" : 101, "height" : 36 }, "textPosition" : { "x" : 1815, "y" : 881 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1909, "y" : 894 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1909, "y" : 894 } } }, "connectors" : [ { "edgeId" : 132910, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1881, "y" : 933 }, "to" : { "x" : 1920, "y" : 959 } }, { "from" : { "x" : 1920, "y" : 959 }, "to" : { "x" : 2206, "y" : 999 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2205, "y" : 1003 }, "b" : { "x" : 2207, "y" : 995 }, "c" : { "x" : 2206, "y" : 999 }, "type" : "STOP", "centre" : { "x" : 2206, "y" : 999 } } }, { "edgeId" : 133234, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132912, "reactomeId" : 390627, "displayName" : "ADR, NAd", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2291, "y" : 1000 }, "minX" : 2217, "maxX" : 2353, "minY" : 989, "maxY" : 1012, "prop" : { "x" : 2256, "y" : 989, "width" : 70, "height" : 23 }, "textPosition" : { "x" : 2258, "y" : 990 }, "connectors" : [ { "edgeId" : 132910, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2250, "y" : 1000 }, "to" : { "x" : 2217, "y" : 1000 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 132916, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2332, "y" : 1000 }, "to" : { "x" : 2353, "y" : 1000 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132913, "reactomeId" : 10358028, "displayName" : "ADRA1A,B,D:ADR,NAd", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2215, "y" : 911 }, "minX" : 2163, "maxX" : 2274, "minY" : 887, "maxY" : 929, "prop" : { "x" : 2163, "y" : 893, "width" : 105, "height" : 36 }, "textPosition" : { "x" : 2172, "y" : 894 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2268, "y" : 893 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2268, "y" : 893 } } }, "connectors" : [ { "edgeId" : 132910, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132918, "reactomeId" : 10358635, "displayName" : "ADRA2A,B,C:ADR,NAd", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2508, "y" : 909 }, "minX" : 2455, "maxX" : 2567, "minY" : 885, "maxY" : 927, "prop" : { "x" : 2455, "y" : 891, "width" : 106, "height" : 36 }, "textPosition" : { "x" : 2465, "y" : 892 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2561, "y" : 891 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2561, "y" : 891 } } }, "connectors" : [ { "edgeId" : 132916, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132917, "reactomeId" : 10358633, "displayName" : "ADRA2A,B,C", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2354, "y" : 914 }, "minX" : 2309, "maxX" : 2583, "minY" : 900, "maxY" : 1010, "prop" : { "x" : 2309, "y" : 900, "width" : 90, "height" : 29 }, "textPosition" : { "x" : 2313, "y" : 904 }, "connectors" : [ { "edgeId" : 132916, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2353, "y" : 935 }, "to" : { "x" : 2353, "y" : 1000 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133238, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2388, "y" : 935 }, "to" : { "x" : 2583, "y" : 1010 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132922, "reactomeId" : 10357502, "displayName" : "ADRB1:ADR,NAd", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4044, "y" : 1301 }, "minX" : 4002, "maxX" : 4092, "minY" : 1276, "maxY" : 1321, "prop" : { "x" : 4002, "y" : 1282, "width" : 84, "height" : 39 }, "textPosition" : { "x" : 4003, "y" : 1286 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4086, "y" : 1282 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4086, "y" : 1282 } } }, "connectors" : [ { "edgeId" : 132919, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132923, "reactomeId" : 10360929, "displayName" : "β1,2-agonists:ADBR1,2", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 4030, "y" : 1454 }, "minX" : 3984, "maxX" : 4174, "minY" : 1310, "maxY" : 1546, "prop" : { "x" : 3984, "y" : 1435, "width" : 93, "height" : 38 }, "textPosition" : { "x" : 3997, "y" : 1424 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4077, "y" : 1435 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4077, "y" : 1435 } } }, "connectors" : [ { "edgeId" : 132919, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 4080, "y" : 1453 }, "to" : { "x" : 4143, "y" : 1453 } }, { "from" : { "x" : 4143, "y" : 1453 }, "to" : { "x" : 4116, "y" : 1310 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 4121, "y" : 1316 }, "b" : { "x" : 4116, "y" : 1310 }, "c" : { "x" : 4113, "y" : 1318 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 4113, "y" : 1318 } } }, { "edgeId" : 133218, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133221, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 4059, "y" : 1476 }, "to" : { "x" : 4174, "y" : 1546 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 4166, "y" : 1546 }, "b" : { "x" : 4174, "y" : 1546 }, "c" : { "x" : 4170, "y" : 1539 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 4170, "y" : 1539 } } } ] }, { "id" : 132920, "reactomeId" : 390627, "displayName" : "ADR, NAd", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 4204, "y" : 1301 }, "minX" : 4113, "maxX" : 4225, "minY" : 1150, "maxY" : 1550, "prop" : { "x" : 4184, "y" : 1283, "width" : 41, "height" : 37 }, "textPosition" : { "x" : 4184, "y" : 1284 }, "connectors" : [ { "edgeId" : 132919, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4178, "y" : 1300 }, "to" : { "x" : 4113, "y" : 1300 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133221, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4202, "y" : 1326 }, "to" : { "x" : 4182, "y" : 1550 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133224, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4197, "y" : 1277 }, "to" : { "x" : 4149, "y" : 1150 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132921, "reactomeId" : 10357500, "displayName" : "ADRB1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 4052, "y" : 1256 }, "minX" : 4026, "maxX" : 4130, "minY" : 1220, "maxY" : 1300, "prop" : { "x" : 4026, "y" : 1245, "width" : 52, "height" : 22 }, "textPosition" : { "x" : 4027, "y" : 1245 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4078, "y" : 1245 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4078, "y" : 1245 } } }, "connectors" : [ { "edgeId" : 132919, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4067, "y" : 1270 }, "to" : { "x" : 4113, "y" : 1300 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133230, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4075, "y" : 1242 }, "to" : { "x" : 4130, "y" : 1220 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132927, "reactomeId" : 10357524, "displayName" : "DRD1,5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 305, "y" : 1122 }, "minX" : 276, "maxX" : 334, "minY" : 1087, "maxY" : 1136, "prop" : { "x" : 276, "y" : 1109, "width" : 58, "height" : 27 }, "textPosition" : { "x" : 278, "y" : 1112 }, "connectors" : [ { "edgeId" : 132926, "type" : "INPUT", "segments" : [ { "from" : { "x" : 310, "y" : 1103 }, "to" : { "x" : 319, "y" : 1087 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132924, "reactomeId" : 10360931, "displayName" : "β1-agonists:ADBR1", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 4030, "y" : 1213 }, "minX" : 3991, "maxX" : 4118, "minY" : 1183, "maxY" : 1292, "prop" : { "x" : 3991, "y" : 1189, "width" : 78, "height" : 48 }, "textPosition" : { "x" : 3997, "y" : 1188 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4069, "y" : 1189 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4069, "y" : 1189 } } }, "connectors" : [ { "edgeId" : 132919, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 4072, "y" : 1232 }, "to" : { "x" : 4114, "y" : 1256 } }, { "from" : { "x" : 4114, "y" : 1256 }, "to" : { "x" : 4114, "y" : 1292 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 4110, "y" : 1285 }, "b" : { "x" : 4114, "y" : 1292 }, "c" : { "x" : 4118, "y" : 1285 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 4118, "y" : 1285 } } }, { "edgeId" : 133230, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132925, "reactomeId" : 10360925, "displayName" : "ADRB1,2,3:β-blockers", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 4041, "y" : 1355 }, "minX" : 4003, "maxX" : 4180, "minY" : 1161, "maxY" : 1546, "prop" : { "x" : 4003, "y" : 1337, "width" : 77, "height" : 36 }, "textPosition" : { "x" : 4003, "y" : 1338 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4080, "y" : 1337 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4080, "y" : 1337 } } }, "connectors" : [ { "edgeId" : 132919, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 4083, "y" : 1353 }, "to" : { "x" : 4113, "y" : 1353 } }, { "from" : { "x" : 4113, "y" : 1353 }, "to" : { "x" : 4114, "y" : 1310 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 4110, "y" : 1310 }, "b" : { "x" : 4118, "y" : 1310 }, "c" : { "x" : 4114, "y" : 1310 }, "type" : "STOP", "centre" : { "x" : 4114, "y" : 1310 } } }, { "edgeId" : 133210, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133221, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 4053, "y" : 1376 }, "to" : { "x" : 4177, "y" : 1544 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 4174, "y" : 1546 }, "b" : { "x" : 4180, "y" : 1542 }, "c" : { "x" : 4177, "y" : 1544 }, "type" : "STOP", "centre" : { "x" : 4177, "y" : 1544 } } }, { "edgeId" : 133224, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 4083, "y" : 1356 }, "to" : { "x" : 4148, "y" : 1360 } }, { "from" : { "x" : 4148, "y" : 1360 }, "to" : { "x" : 4149, "y" : 1161 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 4145, "y" : 1161 }, "b" : { "x" : 4153, "y" : 1161 }, "c" : { "x" : 4149, "y" : 1161 }, "type" : "STOP", "centre" : { "x" : 4149, "y" : 1161 } } } ] }, { "id" : 132931, "reactomeId" : 10358617, "displayName" : "DRD3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 476, "y" : 1122 }, "minX" : 438, "maxX" : 520, "minY" : 1085, "maxY" : 1136, "prop" : { "x" : 438, "y" : 1108, "width" : 76, "height" : 28 }, "textPosition" : { "x" : 455, "y" : 1111 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 514, "y" : 1108 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 514, "y" : 1108 } } }, "connectors" : [ { "edgeId" : 132930, "type" : "INPUT", "segments" : [ { "from" : { "x" : 483, "y" : 1102 }, "to" : { "x" : 495, "y" : 1085 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132928, "reactomeId" : 380873, "displayName" : "DA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 315, "y" : 1036 }, "minX" : 235, "maxX" : 495, "minY" : 1021, "maxY" : 1117, "prop" : { "x" : 297, "y" : 1022, "width" : 36, "height" : 29 }, "textPosition" : { "x" : 302, "y" : 1026 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 328, "y" : 1027 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 328, "y" : 1027 } } }, "connectors" : [ { "edgeId" : 132926, "type" : "INPUT", "segments" : [ { "from" : { "x" : 316, "y" : 1054 }, "to" : { "x" : 319, "y" : 1087 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 132930, "type" : "INPUT", "segments" : [ { "from" : { "x" : 336, "y" : 1040 }, "to" : { "x" : 495, "y" : 1085 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133245, "type" : "INPUT", "segments" : [ { "from" : { "x" : 300, "y" : 1054 }, "to" : { "x" : 235, "y" : 1117 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132929, "reactomeId" : 10357526, "displayName" : "DRD1,5:DA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 381, "y" : 1126 }, "minX" : 352, "maxX" : 417, "minY" : 1103, "maxY" : 1143, "prop" : { "x" : 352, "y" : 1109, "width" : 59, "height" : 34 }, "textPosition" : { "x" : 352, "y" : 1108 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 411, "y" : 1109 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 411, "y" : 1109 } } }, "connectors" : [ { "edgeId" : 132926, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132934, "reactomeId" : 10357530, "displayName" : "HRH2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 624, "y" : 2701 }, "minX" : 593, "maxX" : 688, "minY" : 2682, "maxY" : 2741, "prop" : { "x" : 602, "y" : 2688, "width" : 44, "height" : 27 }, "textPosition" : { "x" : 603, "y" : 2691 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 646, "y" : 2688 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 646, "y" : 2688 } } }, "connectors" : [ { "edgeId" : 132933, "type" : "INPUT", "segments" : [ { "from" : { "x" : 613, "y" : 2718 }, "to" : { "x" : 593, "y" : 2741 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133273, "type" : "INPUT", "segments" : [ { "from" : { "x" : 649, "y" : 2714 }, "to" : { "x" : 688, "y" : 2739 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132935, "reactomeId" : 390899, "displayName" : "Hist", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 594, "y" : 2817 }, "minX" : 569, "maxX" : 620, "minY" : 2741, "maxY" : 2833, "prop" : { "x" : 569, "y" : 2801, "width" : 50, "height" : 32 }, "textPosition" : { "x" : 578, "y" : 2806 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 614, "y" : 2806 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 614, "y" : 2806 } } }, "connectors" : [ { "edgeId" : 132933, "type" : "INPUT", "segments" : [ { "from" : { "x" : 593, "y" : 2798 }, "to" : { "x" : 593, "y" : 2741 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132932, "reactomeId" : 10358619, "displayName" : "DRD3,4:DA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 577, "y" : 1124 }, "minX" : 542, "maxX" : 618, "minY" : 1100, "maxY" : 1142, "prop" : { "x" : 542, "y" : 1106, "width" : 70, "height" : 36 }, "textPosition" : { "x" : 548, "y" : 1107 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 612, "y" : 1106 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 612, "y" : 1106 } } }, "connectors" : [ { "edgeId" : 132930, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132938, "reactomeId" : 10358611, "displayName" : "HRH4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2787, "y" : 2700 }, "minX" : 2713, "maxX" : 2815, "minY" : 2683, "maxY" : 2768, "prop" : { "x" : 2766, "y" : 2689, "width" : 43, "height" : 22 }, "textPosition" : { "x" : 2766, "y" : 2689 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2809, "y" : 2689 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2809, "y" : 2689 } } }, "connectors" : [ { "edgeId" : 132937, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2775, "y" : 2714 }, "to" : { "x" : 2713, "y" : 2768 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132939, "reactomeId" : 390899, "displayName" : "Hist", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2597, "y" : 2833 }, "minX" : 2572, "maxX" : 2713, "minY" : 2757, "maxY" : 2849, "prop" : { "x" : 2572, "y" : 2817, "width" : 50, "height" : 32 }, "textPosition" : { "x" : 2581, "y" : 2822 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2617, "y" : 2822 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2617, "y" : 2822 } } }, "connectors" : [ { "edgeId" : 132937, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2625, "y" : 2818 }, "to" : { "x" : 2713, "y" : 2768 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133276, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2592, "y" : 2814 }, "to" : { "x" : 2576, "y" : 2757 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132936, "reactomeId" : 10357532, "displayName" : "HRH2:histamine", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 530, "y" : 2704 }, "minX" : 496, "maxX" : 570, "minY" : 2679, "maxY" : 2723, "prop" : { "x" : 496, "y" : 2685, "width" : 68, "height" : 38 }, "textPosition" : { "x" : 499, "y" : 2674 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 564, "y" : 2685 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 564, "y" : 2685 } } }, "connectors" : [ { "edgeId" : 132933, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132942, "reactomeId" : 10358605, "displayName" : "HTR1B,D,E,F,HTR5A", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1030, "y" : 1124 }, "minX" : 980, "maxX" : 1080, "minY" : 1080, "maxY" : 1143, "prop" : { "x" : 980, "y" : 1106, "width" : 100, "height" : 37 }, "textPosition" : { "x" : 986, "y" : 1107 }, "connectors" : [ { "edgeId" : 132941, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1047, "y" : 1100 }, "to" : { "x" : 1072, "y" : 1080 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132943, "reactomeId" : 114523, "displayName" : "5HT", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1202, "y" : 1023 }, "minX" : 1072, "maxX" : 1492, "minY" : 1006, "maxY" : 1083, "prop" : { "x" : 1180, "y" : 1007, "width" : 45, "height" : 32 }, "textPosition" : { "x" : 1186, "y" : 1012 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1220, "y" : 1012 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1220, "y" : 1012 } } }, "connectors" : [ { "edgeId" : 132941, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1177, "y" : 1032 }, "to" : { "x" : 1072, "y" : 1080 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 132945, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1218, "y" : 1042 }, "to" : { "x" : 1263, "y" : 1083 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 132948, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1228, "y" : 1027 }, "to" : { "x" : 1492, "y" : 1081 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132940, "reactomeId" : 10358613, "displayName" : "HRH4:Hist", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2697, "y" : 2701 }, "minX" : 2655, "maxX" : 2746, "minY" : 2683, "maxY" : 2714, "prop" : { "x" : 2655, "y" : 2689, "width" : 85, "height" : 25 }, "textPosition" : { "x" : 2662, "y" : 2693 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2740, "y" : 2689 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2740, "y" : 2689 } } }, "connectors" : [ { "edgeId" : 132937, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132946, "reactomeId" : 10358038, "displayName" : "HTR2A-C", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1260, "y" : 1125 }, "minX" : 1228, "maxX" : 1293, "minY" : 1083, "maxY" : 1140, "prop" : { "x" : 1228, "y" : 1110, "width" : 65, "height" : 30 }, "textPosition" : { "x" : 1230, "y" : 1114 }, "connectors" : [ { "edgeId" : 132945, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1261, "y" : 1104 }, "to" : { "x" : 1263, "y" : 1083 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132947, "reactomeId" : 10358040, "displayName" : "HTR2A-C:5HT", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1369, "y" : 1124 }, "minX" : 1332, "maxX" : 1412, "minY" : 1097, "maxY" : 1146, "prop" : { "x" : 1332, "y" : 1103, "width" : 74, "height" : 43 }, "textPosition" : { "x" : 1337, "y" : 1111 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1406, "y" : 1103 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1406, "y" : 1103 } } }, "connectors" : [ { "edgeId" : 132945, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132944, "reactomeId" : 10358607, "displayName" : "HTR1B,D,E,F,HTR5A:5HT", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1151, "y" : 1124 }, "minX" : 1101, "maxX" : 1207, "minY" : 1099, "maxY" : 1144, "prop" : { "x" : 1101, "y" : 1105, "width" : 100, "height" : 39 }, "textPosition" : { "x" : 1107, "y" : 1109 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1201, "y" : 1105 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1201, "y" : 1105 } } }, "connectors" : [ { "edgeId" : 132941, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132950, "reactomeId" : 10357548, "displayName" : "HTR4,6,7:5HT", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1574, "y" : 1121 }, "minX" : 1536, "maxX" : 1618, "minY" : 1095, "maxY" : 1142, "prop" : { "x" : 1536, "y" : 1101, "width" : 76, "height" : 41 }, "textPosition" : { "x" : 1540, "y" : 1107 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1612, "y" : 1101 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1612, "y" : 1101 } } }, "connectors" : [ { "edgeId" : 132948, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132949, "reactomeId" : 10357546, "displayName" : "HTR4,6,7", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1473, "y" : 1121 }, "minX" : 1433, "maxX" : 1513, "minY" : 1081, "maxY" : 1138, "prop" : { "x" : 1433, "y" : 1105, "width" : 80, "height" : 33 }, "textPosition" : { "x" : 1441, "y" : 1111 }, "connectors" : [ { "edgeId" : 132948, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1480, "y" : 1099 }, "to" : { "x" : 1492, "y" : 1081 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132954, "reactomeId" : 10357592, "displayName" : "Trace amine-associated receptor:PEA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2220, "y" : 1124 }, "minX" : 2172, "maxX" : 2274, "minY" : 1092, "maxY" : 1150, "prop" : { "x" : 2172, "y" : 1098, "width" : 96, "height" : 52 }, "textPosition" : { "x" : 2175, "y" : 1101 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2268, "y" : 1098 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2268, "y" : 1098 } } }, "connectors" : [ { "edgeId" : 132951, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132952, "reactomeId" : 10357590, "displayName" : "Trace amine-associated receptor", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2098, "y" : 1124 }, "minX" : 2052, "maxX" : 2145, "minY" : 1074, "maxY" : 1152, "prop" : { "x" : 2052, "y" : 1097, "width" : 93, "height" : 55 }, "textPosition" : { "x" : 2054, "y" : 1100 }, "connectors" : [ { "edgeId" : 132951, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2123, "y" : 1091 }, "to" : { "x" : 2144, "y" : 1074 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132953, "reactomeId" : 391200, "displayName" : "PEA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2097, "y" : 1061 }, "minX" : 2075, "maxX" : 2144, "minY" : 1047, "maxY" : 1075, "prop" : { "x" : 2075, "y" : 1048, "width" : 45, "height" : 27 }, "textPosition" : { "x" : 2081, "y" : 1051 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2115, "y" : 1053 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2115, "y" : 1053 } } }, "connectors" : [ { "edgeId" : 132951, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2123, "y" : 1067 }, "to" : { "x" : 2144, "y" : 1074 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132958, "reactomeId" : 10357598, "displayName" : "FSHR:Follitropin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1792, "y" : 1125 }, "minX" : 1759, "maxX" : 1831, "minY" : 1100, "maxY" : 1144, "prop" : { "x" : 1759, "y" : 1106, "width" : 66, "height" : 38 }, "textPosition" : { "x" : 1761, "y" : 1095 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1825, "y" : 1106 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1825, "y" : 1106 } } }, "connectors" : [ { "edgeId" : 132955, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132956, "reactomeId" : 10357456, "displayName" : "Follitropin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1715, "y" : 1068 }, "minX" : 1681, "maxX" : 1758, "minY" : 1051, "maxY" : 1090, "prop" : { "x" : 1681, "y" : 1057, "width" : 68, "height" : 23 }, "textPosition" : { "x" : 1684, "y" : 1045 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1749, "y" : 1057 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1749, "y" : 1057 } } }, "connectors" : [ { "edgeId" : 132955, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1737, "y" : 1083 }, "to" : { "x" : 1758, "y" : 1090 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132957, "reactomeId" : 10357596, "displayName" : "FSHR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1717, "y" : 1121 }, "minX" : 1688, "maxX" : 1758, "minY" : 1090, "maxY" : 1138, "prop" : { "x" : 1688, "y" : 1105, "width" : 58, "height" : 33 }, "textPosition" : { "x" : 1697, "y" : 1111 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1746, "y" : 1105 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1746, "y" : 1105 } } }, "connectors" : [ { "edgeId" : 132955, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1738, "y" : 1102 }, "to" : { "x" : 1758, "y" : 1090 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132962, "reactomeId" : 10358056, "displayName" : "GNRHR:GNRH1,2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1933, "y" : 2701 }, "minX" : 1898, "maxX" : 1975, "minY" : 2677, "maxY" : 2720, "prop" : { "x" : 1898, "y" : 2683, "width" : 71, "height" : 37 }, "textPosition" : { "x" : 1902, "y" : 2685 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1969, "y" : 2683 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1969, "y" : 2683 } } }, "connectors" : [ { "edgeId" : 132959, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132960, "reactomeId" : 10358050, "displayName" : "GNRH1,2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1874, "y" : 2765 }, "minX" : 1842, "maxX" : 1906, "minY" : 2731, "maxY" : 2777, "prop" : { "x" : 1842, "y" : 2754, "width" : 64, "height" : 23 }, "textPosition" : { "x" : 1842, "y" : 2755 }, "connectors" : [ { "edgeId" : 132959, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1873, "y" : 2748 }, "to" : { "x" : 1872, "y" : 2731 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132961, "reactomeId" : 10358054, "displayName" : "GNRHR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1824, "y" : 2703 }, "minX" : 1640, "maxX" : 1953, "minY" : 2686, "maxY" : 2804, "prop" : { "x" : 1798, "y" : 2692, "width" : 52, "height" : 22 }, "textPosition" : { "x" : 1798, "y" : 2692 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1850, "y" : 2692 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1850, "y" : 2692 } } }, "connectors" : [ { "edgeId" : 132959, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1842, "y" : 2717 }, "to" : { "x" : 1872, "y" : 2731 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133305, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1806, "y" : 2717 }, "to" : { "x" : 1744, "y" : 2752 } }, { "from" : { "x" : 1744, "y" : 2752 }, "to" : { "x" : 1640, "y" : 2752 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133311, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1838, "y" : 2717 }, "to" : { "x" : 1953, "y" : 2804 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133308, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1817, "y" : 2717 }, "to" : { "x" : 1777, "y" : 2780 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132966, "reactomeId" : 10357604, "displayName" : "LH receptor:LH", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3600, "y" : 1125 }, "minX" : 3560, "maxX" : 3647, "minY" : 1099, "maxY" : 1146, "prop" : { "x" : 3560, "y" : 1105, "width" : 81, "height" : 41 }, "textPosition" : { "x" : 3560, "y" : 1111 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3641, "y" : 1105 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3641, "y" : 1105 } } }, "connectors" : [ { "edgeId" : 132963, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132964, "reactomeId" : 10349222, "displayName" : "glyco-Lutropin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3466, "y" : 1074 }, "minX" : 3417, "maxX" : 3521, "minY" : 1057, "maxY" : 1099, "prop" : { "x" : 3417, "y" : 1063, "width" : 98, "height" : 22 }, "textPosition" : { "x" : 3418, "y" : 1064 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3515, "y" : 1063 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3515, "y" : 1063 } } }, "connectors" : [ { "edgeId" : 132963, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3486, "y" : 1088 }, "to" : { "x" : 3513, "y" : 1099 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132965, "reactomeId" : 10357602, "displayName" : "LHCGR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3459, "y" : 1123 }, "minX" : 3423, "maxX" : 3513, "minY" : 1099, "maxY" : 1138, "prop" : { "x" : 3423, "y" : 1109, "width" : 72, "height" : 29 }, "textPosition" : { "x" : 3435, "y" : 1113 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3495, "y" : 1109 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3495, "y" : 1109 } } }, "connectors" : [ { "edgeId" : 132963, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3491, "y" : 1106 }, "to" : { "x" : 3513, "y" : 1099 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132970, "reactomeId" : 10357622, "displayName" : "TSHR:Thyrotropin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3812, "y" : 1121 }, "minX" : 3769, "maxX" : 3861, "minY" : 1098, "maxY" : 1139, "prop" : { "x" : 3769, "y" : 1104, "width" : 86, "height" : 35 }, "textPosition" : { "x" : 3772, "y" : 1104 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3855, "y" : 1104 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3855, "y" : 1104 } } }, "connectors" : [ { "edgeId" : 132967, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132968, "reactomeId" : 10357608, "displayName" : "TSHR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3684, "y" : 1125 }, "minX" : 3662, "maxX" : 3744, "minY" : 1105, "maxY" : 1139, "prop" : { "x" : 3662, "y" : 1112, "width" : 45, "height" : 27 }, "textPosition" : { "x" : 3664, "y" : 1115 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3707, "y" : 1112 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3707, "y" : 1112 } } }, "connectors" : [ { "edgeId" : 132967, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3710, "y" : 1115 }, "to" : { "x" : 3729, "y" : 1105 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 132967, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3710, "y" : 1125 }, "to" : { "x" : 3735, "y" : 1125 } }, { "from" : { "x" : 3735, "y" : 1125 }, "to" : { "x" : 3738, "y" : 1118 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3740, "y" : 1115 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3740, "y" : 1115 } } } ] }, { "id" : 132969, "reactomeId" : 10357620, "displayName" : "Thyrotropin, Thyrostimulin", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3683, "y" : 1071 }, "minX" : 3640, "maxX" : 3729, "minY" : 1053, "maxY" : 1105, "prop" : { "x" : 3640, "y" : 1053, "width" : 86, "height" : 36 }, "textPosition" : { "x" : 3640, "y" : 1047 }, "connectors" : [ { "edgeId" : 132967, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3707, "y" : 1095 }, "to" : { "x" : 3729, "y" : 1105 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132974, "reactomeId" : 10358330, "displayName" : "PTGER1:PGE2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2637, "y" : 1124 }, "minX" : 2599, "maxX" : 2681, "minY" : 1102, "maxY" : 1141, "prop" : { "x" : 2599, "y" : 1108, "width" : 76, "height" : 33 }, "textPosition" : { "x" : 2607, "y" : 1106 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2675, "y" : 1108 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2675, "y" : 1108 } } }, "connectors" : [ { "edgeId" : 132971, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132972, "reactomeId" : 391930, "displayName" : "PGE2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2545, "y" : 1057 }, "minX" : 2505, "maxX" : 2968, "minY" : 1043, "maxY" : 1093, "prop" : { "x" : 2505, "y" : 1044, "width" : 80, "height" : 27 }, "textPosition" : { "x" : 2524, "y" : 1047 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2580, "y" : 1049 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2580, "y" : 1049 } } }, "connectors" : [ { "edgeId" : 132971, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2557, "y" : 1074 }, "to" : { "x" : 2577, "y" : 1093 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 132975, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2588, "y" : 1062 }, "to" : { "x" : 2782, "y" : 1087 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 132978, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2588, "y" : 1058 }, "to" : { "x" : 2968, "y" : 1073 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132973, "reactomeId" : 10358328, "displayName" : "PTGER1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2543, "y" : 1121 }, "minX" : 2514, "maxX" : 2579, "minY" : 1093, "maxY" : 1136, "prop" : { "x" : 2514, "y" : 1107, "width" : 59, "height" : 29 }, "textPosition" : { "x" : 2515, "y" : 1111 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2573, "y" : 1107 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2573, "y" : 1107 } } }, "connectors" : [ { "edgeId" : 132971, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2560, "y" : 1104 }, "to" : { "x" : 2577, "y" : 1093 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132979, "reactomeId" : 10358771, "displayName" : "PTGER3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2961, "y" : 1121 }, "minX" : 2931, "maxX" : 2997, "minY" : 1073, "maxY" : 1137, "prop" : { "x" : 2931, "y" : 1105, "width" : 60, "height" : 32 }, "textPosition" : { "x" : 2933, "y" : 1110 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2991, "y" : 1105 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2991, "y" : 1105 } } }, "connectors" : [ { "edgeId" : 132978, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2963, "y" : 1102 }, "to" : { "x" : 2968, "y" : 1073 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132976, "reactomeId" : 10357887, "displayName" : "PTGER2,PTGER4", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2746, "y" : 1120 }, "minX" : 2709, "maxX" : 2783, "minY" : 1087, "maxY" : 1138, "prop" : { "x" : 2709, "y" : 1103, "width" : 74, "height" : 35 }, "textPosition" : { "x" : 2716, "y" : 1103 }, "connectors" : [ { "edgeId" : 132975, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2765, "y" : 1097 }, "to" : { "x" : 2782, "y" : 1087 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132977, "reactomeId" : 10357889, "displayName" : "PTGER2,PTGER4:PGE2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2867, "y" : 1118 }, "minX" : 2829, "maxX" : 2912, "minY" : 1086, "maxY" : 1144, "prop" : { "x" : 2829, "y" : 1092, "width" : 77, "height" : 52 }, "textPosition" : { "x" : 2837, "y" : 1095 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2906, "y" : 1092 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2906, "y" : 1092 } } }, "connectors" : [ { "edgeId" : 132975, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132982, "reactomeId" : 391928, "displayName" : "PGF2a", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1686, "y" : 2363 }, "minX" : 1662, "maxX" : 1712, "minY" : 2346, "maxY" : 2411, "prop" : { "x" : 1662, "y" : 2347, "width" : 49, "height" : 33 }, "textPosition" : { "x" : 1662, "y" : 2353 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1706, "y" : 2352 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1706, "y" : 2352 } } }, "connectors" : [ { "edgeId" : 132981, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1684, "y" : 2383 }, "to" : { "x" : 1682, "y" : 2411 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132983, "reactomeId" : 10358334, "displayName" : "PTGFR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1633, "y" : 2483 }, "minX" : 1585, "maxX" : 1682, "minY" : 2409, "maxY" : 2498, "prop" : { "x" : 1608, "y" : 2468, "width" : 51, "height" : 30 }, "textPosition" : { "x" : 1610, "y" : 2472 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1659, "y" : 2468 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1659, "y" : 2468 } } }, "connectors" : [ { "edgeId" : 132981, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1643, "y" : 2465 }, "to" : { "x" : 1682, "y" : 2411 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133302, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1623, "y" : 2465 }, "to" : { "x" : 1585, "y" : 2409 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132980, "reactomeId" : 10358773, "displayName" : "PTGER3:PGE2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3051, "y" : 1119 }, "minX" : 3019, "maxX" : 3089, "minY" : 1096, "maxY" : 1137, "prop" : { "x" : 3019, "y" : 1102, "width" : 64, "height" : 35 }, "textPosition" : { "x" : 3021, "y" : 1102 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3083, "y" : 1102 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3083, "y" : 1102 } } }, "connectors" : [ { "edgeId" : 132978, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132986, "reactomeId" : 391926, "displayName" : "PGI2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3118, "y" : 1067 }, "minX" : 3095, "maxX" : 3147, "minY" : 1053, "maxY" : 1092, "prop" : { "x" : 3095, "y" : 1054, "width" : 46, "height" : 26 }, "textPosition" : { "x" : 3100, "y" : 1056 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3136, "y" : 1059 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3136, "y" : 1059 } } }, "connectors" : [ { "edgeId" : 132985, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3133, "y" : 1083 }, "to" : { "x" : 3147, "y" : 1092 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132987, "reactomeId" : 10357652, "displayName" : "PTGIR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3124, "y" : 1123 }, "minX" : 3102, "maxX" : 3153, "minY" : 1092, "maxY" : 1138, "prop" : { "x" : 3102, "y" : 1108, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 3103, "y" : 1112 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3147, "y" : 1108 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3147, "y" : 1108 } } }, "connectors" : [ { "edgeId" : 132985, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3135, "y" : 1105 }, "to" : { "x" : 3147, "y" : 1092 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132984, "reactomeId" : 10358336, "displayName" : "PTGFR:PGF2a", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1700, "y" : 2480 }, "minX" : 1673, "maxX" : 1733, "minY" : 2455, "maxY" : 2500, "prop" : { "x" : 1673, "y" : 2461, "width" : 54, "height" : 39 }, "textPosition" : { "x" : 1674, "y" : 2465 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1727, "y" : 2461 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1727, "y" : 2461 } } }, "connectors" : [ { "edgeId" : 132981, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132990, "reactomeId" : 391932, "displayName" : "TXA2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1325, "y" : 1676 }, "minX" : 1294, "maxX" : 1358, "minY" : 1641, "maxY" : 1692, "prop" : { "x" : 1294, "y" : 1661, "width" : 63, "height" : 31 }, "textPosition" : { "x" : 1306, "y" : 1666 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1352, "y" : 1666 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1352, "y" : 1666 } } }, "connectors" : [ { "edgeId" : 132989, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1335, "y" : 1658 }, "to" : { "x" : 1349, "y" : 1641 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132991, "reactomeId" : 10358120, "displayName" : "TBXA2R", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1323, "y" : 1608 }, "minX" : 1288, "maxX" : 1364, "minY" : 1587, "maxY" : 1641, "prop" : { "x" : 1288, "y" : 1593, "width" : 70, "height" : 31 }, "textPosition" : { "x" : 1296, "y" : 1598 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1358, "y" : 1593 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1358, "y" : 1593 } } }, "connectors" : [ { "edgeId" : 132989, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1335, "y" : 1627 }, "to" : { "x" : 1349, "y" : 1641 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132988, "reactomeId" : 10357654, "displayName" : "PTGIR:PGI2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3217, "y" : 1118 }, "minX" : 3185, "maxX" : 3255, "minY" : 1095, "maxY" : 1136, "prop" : { "x" : 3185, "y" : 1101, "width" : 64, "height" : 35 }, "textPosition" : { "x" : 3193, "y" : 1101 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3249, "y" : 1101 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3249, "y" : 1101 } } }, "connectors" : [ { "edgeId" : 132985, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132994, "reactomeId" : 416911, "displayName" : "PGD2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 206, "y" : 1660 }, "minX" : 178, "maxX" : 430, "minY" : 1633, "maxY" : 1674, "prop" : { "x" : 178, "y" : 1647, "width" : 56, "height" : 27 }, "textPosition" : { "x" : 185, "y" : 1650 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 229, "y" : 1652 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 229, "y" : 1652 } } }, "connectors" : [ { "edgeId" : 132993, "type" : "INPUT", "segments" : [ { "from" : { "x" : 230, "y" : 1644 }, "to" : { "x" : 254, "y" : 1633 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 132997, "type" : "INPUT", "segments" : [ { "from" : { "x" : 237, "y" : 1659 }, "to" : { "x" : 430, "y" : 1654 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132995, "reactomeId" : 10357875, "displayName" : "PTGDR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 206, "y" : 1613 }, "minX" : 177, "maxX" : 254, "minY" : 1593, "maxY" : 1633, "prop" : { "x" : 177, "y" : 1599, "width" : 59, "height" : 29 }, "textPosition" : { "x" : 182, "y" : 1603 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 236, "y" : 1599 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 236, "y" : 1599 } } }, "connectors" : [ { "edgeId" : 132993, "type" : "INPUT", "segments" : [ { "from" : { "x" : 239, "y" : 1625 }, "to" : { "x" : 254, "y" : 1633 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132992, "reactomeId" : 10358122, "displayName" : "TBXA2R:TXA2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1422, "y" : 1612 }, "minX" : 1392, "maxX" : 1459, "minY" : 1586, "maxY" : 1632, "prop" : { "x" : 1392, "y" : 1592, "width" : 61, "height" : 40 }, "textPosition" : { "x" : 1393, "y" : 1597 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1453, "y" : 1592 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1453, "y" : 1592 } } }, "connectors" : [ { "edgeId" : 132989, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132998, "reactomeId" : 10358713, "displayName" : "PTGDR2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 413, "y" : 1617 }, "minX" : 383, "maxX" : 450, "minY" : 1597, "maxY" : 1654, "prop" : { "x" : 383, "y" : 1603, "width" : 61, "height" : 28 }, "textPosition" : { "x" : 385, "y" : 1606 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 444, "y" : 1603 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 444, "y" : 1603 } } }, "connectors" : [ { "edgeId" : 132997, "type" : "INPUT", "segments" : [ { "from" : { "x" : 419, "y" : 1634 }, "to" : { "x" : 430, "y" : 1654 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132999, "reactomeId" : 10358715, "displayName" : "PTGDR2:PGD2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 513, "y" : 1615 }, "minX" : 475, "maxX" : 558, "minY" : 1591, "maxY" : 1634, "prop" : { "x" : 475, "y" : 1597, "width" : 77, "height" : 37 }, "textPosition" : { "x" : 483, "y" : 1599 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 552, "y" : 1597 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 552, "y" : 1597 } } }, "connectors" : [ { "edgeId" : 132997, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 132996, "reactomeId" : 10357877, "displayName" : "PTGDR:PGD2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 328, "y" : 1610 }, "minX" : 296, "maxX" : 366, "minY" : 1586, "maxY" : 1629, "prop" : { "x" : 296, "y" : 1592, "width" : 64, "height" : 37 }, "textPosition" : { "x" : 301, "y" : 1594 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 360, "y" : 1592 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 360, "y" : 1592 } } }, "connectors" : [ { "edgeId" : 132993, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133002, "reactomeId" : 10358222, "displayName" : "LTB4R,LTB4R2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1519, "y" : 1614 }, "minX" : 1487, "maxX" : 1585, "minY" : 1598, "maxY" : 1633, "prop" : { "x" : 1487, "y" : 1598, "width" : 65, "height" : 32 }, "textPosition" : { "x" : 1493, "y" : 1597 }, "connectors" : [ { "edgeId" : 133000, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1558, "y" : 1623 }, "to" : { "x" : 1585, "y" : 1633 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133003, "reactomeId" : 10358224, "displayName" : "LTB4R,LTB4R2:LTB", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1658, "y" : 1614 }, "minX" : 1628, "maxX" : 1694, "minY" : 1583, "maxY" : 1640, "prop" : { "x" : 1628, "y" : 1589, "width" : 60, "height" : 51 }, "textPosition" : { "x" : 1629, "y" : 1591 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1688, "y" : 1589 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1688, "y" : 1589 } } }, "connectors" : [ { "edgeId" : 133000, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133001, "reactomeId" : 416436, "displayName" : "LTB4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1523, "y" : 1662 }, "minX" : 1499, "maxX" : 1585, "minY" : 1633, "maxY" : 1677, "prop" : { "x" : 1499, "y" : 1647, "width" : 49, "height" : 30 }, "textPosition" : { "x" : 1505, "y" : 1651 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1543, "y" : 1652 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1543, "y" : 1652 } } }, "connectors" : [ { "edgeId" : 133000, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1551, "y" : 1650 }, "to" : { "x" : 1585, "y" : 1633 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133006, "reactomeId" : 416372, "displayName" : "LTC4,LTD4,LTE4", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1050, "y" : 2372 }, "minX" : 925, "maxX" : 1226, "minY" : 2356, "maxY" : 2480, "prop" : { "x" : 1004, "y" : 2356, "width" : 93, "height" : 33 }, "textPosition" : { "x" : 1013, "y" : 2355 }, "connectors" : [ { "edgeId" : 133004, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1030, "y" : 2395 }, "to" : { "x" : 925, "y" : 2480 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133260, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1076, "y" : 2395 }, "to" : { "x" : 1226, "y" : 2480 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133007, "reactomeId" : 10358134, "displayName" : "CYSLTR2:LTC4,LTD4,LTE4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1007, "y" : 2481 }, "minX" : 968, "maxX" : 1053, "minY" : 2451, "maxY" : 2506, "prop" : { "x" : 968, "y" : 2457, "width" : 79, "height" : 49 }, "textPosition" : { "x" : 970, "y" : 2457 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1047, "y" : 2457 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1047, "y" : 2457 } } }, "connectors" : [ { "edgeId" : 133004, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133005, "reactomeId" : 10358132, "displayName" : "CYSLTR2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 869, "y" : 2481 }, "minX" : 839, "maxX" : 925, "minY" : 2464, "maxY" : 2492, "prop" : { "x" : 839, "y" : 2470, "width" : 60, "height" : 22 }, "textPosition" : { "x" : 839, "y" : 2470 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 899, "y" : 2470 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 899, "y" : 2470 } } }, "connectors" : [ { "edgeId" : 133004, "type" : "INPUT", "segments" : [ { "from" : { "x" : 902, "y" : 2480 }, "to" : { "x" : 925, "y" : 2480 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133010, "reactomeId" : 416372, "displayName" : "LTC4,LTD4,LTE4", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3215, "y" : 1718 }, "minX" : 3169, "maxX" : 3262, "minY" : 1662, "maxY" : 1735, "prop" : { "x" : 3169, "y" : 1702, "width" : 93, "height" : 33 }, "textPosition" : { "x" : 3178, "y" : 1701 }, "connectors" : [ { "edgeId" : 133008, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3223, "y" : 1696 }, "to" : { "x" : 3243, "y" : 1662 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133011, "reactomeId" : 10358709, "displayName" : "GPR17:Cysteinyl leukotrienes", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3309, "y" : 1616 }, "minX" : 3265, "maxX" : 3360, "minY" : 1587, "maxY" : 1640, "prop" : { "x" : 3265, "y" : 1593, "width" : 89, "height" : 47 }, "textPosition" : { "x" : 3266, "y" : 1591 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3354, "y" : 1593 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3354, "y" : 1593 } } }, "connectors" : [ { "edgeId" : 133008, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133009, "reactomeId" : 10358180, "displayName" : "GPR17", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3220, "y" : 1618 }, "minX" : 3196, "maxX" : 3301, "minY" : 1601, "maxY" : 1684, "prop" : { "x" : 3196, "y" : 1607, "width" : 48, "height" : 23 }, "textPosition" : { "x" : 3199, "y" : 1601 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3244, "y" : 1607 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3244, "y" : 1607 } } }, "connectors" : [ { "edgeId" : 133008, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3226, "y" : 1633 }, "to" : { "x" : 3243, "y" : 1662 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133040, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3234, "y" : 1633 }, "to" : { "x" : 3301, "y" : 1684 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133014, "reactomeId" : 10358765, "displayName" : "OXER1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2797, "y" : 1622 }, "minX" : 2772, "maxX" : 2834, "minY" : 1599, "maxY" : 1656, "prop" : { "x" : 2772, "y" : 1605, "width" : 51, "height" : 34 }, "textPosition" : { "x" : 2773, "y" : 1611 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2823, "y" : 1605 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2823, "y" : 1605 } } }, "connectors" : [ { "edgeId" : 133012, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2815, "y" : 1642 }, "to" : { "x" : 2834, "y" : 1656 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133015, "reactomeId" : 10358767, "displayName" : "OXER1:5-oxoETE", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2907, "y" : 1621 }, "minX" : 2866, "maxX" : 2955, "minY" : 1596, "maxY" : 1640, "prop" : { "x" : 2866, "y" : 1602, "width" : 83, "height" : 38 }, "textPosition" : { "x" : 2875, "y" : 1605 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2949, "y" : 1602 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2949, "y" : 1602 } } }, "connectors" : [ { "edgeId" : 133012, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133013, "reactomeId" : 416428, "displayName" : "5-oxoETE", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2794, "y" : 1680 }, "minX" : 2758, "maxX" : 2834, "minY" : 1656, "maxY" : 1696, "prop" : { "x" : 2758, "y" : 1665, "width" : 73, "height" : 31 }, "textPosition" : { "x" : 2762, "y" : 1670 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2826, "y" : 1670 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2826, "y" : 1670 } } }, "connectors" : [ { "edgeId" : 133012, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2819, "y" : 1662 }, "to" : { "x" : 2834, "y" : 1656 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133018, "reactomeId" : 10358072, "displayName" : "P2RY1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 785, "y" : 1613 }, "minX" : 758, "maxX" : 818, "minY" : 1592, "maxY" : 1655, "prop" : { "x" : 758, "y" : 1598, "width" : 54, "height" : 31 }, "textPosition" : { "x" : 761, "y" : 1603 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 812, "y" : 1598 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 812, "y" : 1598 } } }, "connectors" : [ { "edgeId" : 133016, "type" : "INPUT", "segments" : [ { "from" : { "x" : 785, "y" : 1632 }, "to" : { "x" : 786, "y" : 1655 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133019, "reactomeId" : 10358074, "displayName" : "P2RY1:ADP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 849, "y" : 1613 }, "minX" : 821, "maxX" : 884, "minY" : 1589, "maxY" : 1632, "prop" : { "x" : 821, "y" : 1595, "width" : 57, "height" : 37 }, "textPosition" : { "x" : 824, "y" : 1597 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 878, "y" : 1595 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 878, "y" : 1595 } } }, "connectors" : [ { "edgeId" : 133016, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133017, "reactomeId" : 114564, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 976, "y" : 1725 }, "minX" : 786, "maxX" : 1142, "minY" : 1655, "maxY" : 1741, "prop" : { "x" : 956, "y" : 1710, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 959, "y" : 1715 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 991, "y" : 1715 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 991, "y" : 1715 } } }, "connectors" : [ { "edgeId" : 133016, "type" : "INPUT", "segments" : [ { "from" : { "x" : 953, "y" : 1717 }, "to" : { "x" : 786, "y" : 1655 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133024, "type" : "INPUT", "segments" : [ { "from" : { "x" : 999, "y" : 1717 }, "to" : { "x" : 1142, "y" : 1666 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133022, "reactomeId" : 10358078, "displayName" : "P2RY2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1732, "y" : 1618 }, "minX" : 1707, "maxX" : 1765, "minY" : 1597, "maxY" : 1644, "prop" : { "x" : 1707, "y" : 1603, "width" : 50, "height" : 30 }, "textPosition" : { "x" : 1708, "y" : 1607 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1757, "y" : 1603 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1757, "y" : 1603 } } }, "connectors" : [ { "edgeId" : 133020, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1751, "y" : 1636 }, "to" : { "x" : 1765, "y" : 1644 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133023, "reactomeId" : 10358080, "displayName" : "P2RY2:ATP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1834, "y" : 1620 }, "minX" : 1805, "maxX" : 1870, "minY" : 1595, "maxY" : 1639, "prop" : { "x" : 1805, "y" : 1601, "width" : 59, "height" : 38 }, "textPosition" : { "x" : 1809, "y" : 1604 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1864, "y" : 1601 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1864, "y" : 1601 } } }, "connectors" : [ { "edgeId" : 133020, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133021, "reactomeId" : 511955, "displayName" : "ATP,UTP", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1714, "y" : 1753 }, "minX" : 1682, "maxX" : 1765, "minY" : 1644, "maxY" : 1769, "prop" : { "x" : 1682, "y" : 1738, "width" : 65, "height" : 31 }, "textPosition" : { "x" : 1685, "y" : 1743 }, "connectors" : [ { "edgeId" : 133020, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1721, "y" : 1732 }, "to" : { "x" : 1765, "y" : 1644 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133026, "reactomeId" : 10358653, "displayName" : "P2RY12:ADP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1222, "y" : 1612 }, "minX" : 1194, "maxX" : 1257, "minY" : 1587, "maxY" : 1632, "prop" : { "x" : 1194, "y" : 1593, "width" : 57, "height" : 39 }, "textPosition" : { "x" : 1195, "y" : 1597 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1251, "y" : 1593 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1251, "y" : 1593 } } }, "connectors" : [ { "edgeId" : 133024, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133027, "reactomeId" : 10361901, "displayName" : "P2RY12:P2RY12 antagonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 1008, "y" : 1606 }, "minX" : 969, "maxX" : 1136, "minY" : 1576, "maxY" : 1667, "prop" : { "x" : 969, "y" : 1582, "width" : 78, "height" : 49 }, "textPosition" : { "x" : 970, "y" : 1568 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1047, "y" : 1582 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1047, "y" : 1582 } } }, "connectors" : [ { "edgeId" : 133232, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133024, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1050, "y" : 1623 }, "to" : { "x" : 1134, "y" : 1663 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1132, "y" : 1667 }, "b" : { "x" : 1136, "y" : 1659 }, "c" : { "x" : 1134, "y" : 1663 }, "type" : "STOP", "centre" : { "x" : 1134, "y" : 1663 } } } ] }, { "id" : 133025, "reactomeId" : 10358651, "displayName" : "P2RY12", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1119, "y" : 1610 }, "minX" : 1007, "maxX" : 1152, "minY" : 1589, "maxY" : 1668, "prop" : { "x" : 1092, "y" : 1595, "width" : 54, "height" : 30 }, "textPosition" : { "x" : 1095, "y" : 1593 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1146, "y" : 1595 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1146, "y" : 1595 } } }, "connectors" : [ { "edgeId" : 133232, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1089, "y" : 1623 }, "to" : { "x" : 1007, "y" : 1668 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133024, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1125, "y" : 1628 }, "to" : { "x" : 1142, "y" : 1666 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133030, "reactomeId" : 114570, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2377, "y" : 1659 }, "minX" : 2358, "maxX" : 2420, "minY" : 1643, "maxY" : 1675, "prop" : { "x" : 2358, "y" : 1644, "width" : 38, "height" : 31 }, "textPosition" : { "x" : 2361, "y" : 1649 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2391, "y" : 1649 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2391, "y" : 1649 } } }, "connectors" : [ { "edgeId" : 133028, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2399, "y" : 1652 }, "to" : { "x" : 2420, "y" : 1644 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133031, "reactomeId" : 10357871, "displayName" : "P2RY11 :ATP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2490, "y" : 1623 }, "minX" : 2460, "maxX" : 2527, "minY" : 1596, "maxY" : 1644, "prop" : { "x" : 2460, "y" : 1602, "width" : 61, "height" : 42 }, "textPosition" : { "x" : 2461, "y" : 1609 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2521, "y" : 1602 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2521, "y" : 1602 } } }, "connectors" : [ { "edgeId" : 133028, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133029, "reactomeId" : 10357869, "displayName" : "P2RY11", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2375, "y" : 1621 }, "minX" : 2348, "maxX" : 2420, "minY" : 1599, "maxY" : 1644, "prop" : { "x" : 2348, "y" : 1605, "width" : 54, "height" : 32 }, "textPosition" : { "x" : 2351, "y" : 1604 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2402, "y" : 1605 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2402, "y" : 1605 } } }, "connectors" : [ { "edgeId" : 133028, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2405, "y" : 1634 }, "to" : { "x" : 2420, "y" : 1644 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133034, "reactomeId" : 417877, "displayName" : "UTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 564, "y" : 1748 }, "minX" : 544, "maxX" : 642, "minY" : 1638, "maxY" : 1764, "prop" : { "x" : 544, "y" : 1733, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 548, "y" : 1738 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 579, "y" : 1738 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 579, "y" : 1738 } } }, "connectors" : [ { "edgeId" : 133032, "type" : "INPUT", "segments" : [ { "from" : { "x" : 574, "y" : 1730 }, "to" : { "x" : 642, "y" : 1638 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133035, "reactomeId" : 10358647, "displayName" : "P2RY4:UTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 716, "y" : 1616 }, "minX" : 688, "maxX" : 751, "minY" : 1591, "maxY" : 1636, "prop" : { "x" : 688, "y" : 1597, "width" : 57, "height" : 39 }, "textPosition" : { "x" : 691, "y" : 1601 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 745, "y" : 1597 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 745, "y" : 1597 } } }, "connectors" : [ { "edgeId" : 133032, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133033, "reactomeId" : 10358645, "displayName" : "P2RY4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 598, "y" : 1619 }, "minX" : 574, "maxX" : 642, "minY" : 1597, "maxY" : 1638, "prop" : { "x" : 574, "y" : 1603, "width" : 49, "height" : 32 }, "textPosition" : { "x" : 575, "y" : 1608 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 623, "y" : 1603 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 623, "y" : 1603 } } }, "connectors" : [ { "edgeId" : 133032, "type" : "INPUT", "segments" : [ { "from" : { "x" : 626, "y" : 1629 }, "to" : { "x" : 642, "y" : 1638 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133038, "reactomeId" : 417888, "displayName" : "UDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3376, "y" : 1730 }, "minX" : 3301, "maxX" : 3512, "minY" : 1673, "maxY" : 1744, "prop" : { "x" : 3353, "y" : 1716, "width" : 47, "height" : 28 }, "textPosition" : { "x" : 3359, "y" : 1719 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3395, "y" : 1721 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3395, "y" : 1721 } } }, "connectors" : [ { "edgeId" : 133036, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3403, "y" : 1720 }, "to" : { "x" : 3512, "y" : 1673 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133040, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3353, "y" : 1713 }, "to" : { "x" : 3301, "y" : 1684 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133039, "reactomeId" : 10358092, "displayName" : "P2RY6:UDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3572, "y" : 1622 }, "minX" : 3542, "maxX" : 3608, "minY" : 1597, "maxY" : 1641, "prop" : { "x" : 3542, "y" : 1603, "width" : 60, "height" : 38 }, "textPosition" : { "x" : 3546, "y" : 1606 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3602, "y" : 1603 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3602, "y" : 1603 } } }, "connectors" : [ { "edgeId" : 133036, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133037, "reactomeId" : 10358090, "displayName" : "P2RY6", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3489, "y" : 1622 }, "minX" : 3460, "maxX" : 3525, "minY" : 1606, "maxY" : 1673, "prop" : { "x" : 3460, "y" : 1612, "width" : 59, "height" : 21 }, "textPosition" : { "x" : 3466, "y" : 1612 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3519, "y" : 1612 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3519, "y" : 1612 } } }, "connectors" : [ { "edgeId" : 133036, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3493, "y" : 1636 }, "to" : { "x" : 3512, "y" : 1673 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133043, "reactomeId" : 10358084, "displayName" : "LPAR6", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1905, "y" : 1618 }, "minX" : 1879, "maxX" : 1942, "minY" : 1600, "maxY" : 1641, "prop" : { "x" : 1879, "y" : 1606, "width" : 53, "height" : 24 }, "textPosition" : { "x" : 1882, "y" : 1607 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1932, "y" : 1606 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1932, "y" : 1606 } } }, "connectors" : [ { "edgeId" : 133042, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1924, "y" : 1633 }, "to" : { "x" : 1942, "y" : 1641 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133041, "reactomeId" : 10358182, "displayName" : "GPR17:UDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3406, "y" : 1620 }, "minX" : 3368, "maxX" : 3451, "minY" : 1603, "maxY" : 1632, "prop" : { "x" : 3368, "y" : 1609, "width" : 77, "height" : 23 }, "textPosition" : { "x" : 3380, "y" : 1597 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3445, "y" : 1609 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3445, "y" : 1609 } } }, "connectors" : [ { "edgeId" : 133040, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133047, "reactomeId" : 10358096, "displayName" : "LPAR4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2075, "y" : 1620 }, "minX" : 2052, "maxX" : 2104, "minY" : 1601, "maxY" : 1648, "prop" : { "x" : 2052, "y" : 1607, "width" : 46, "height" : 27 }, "textPosition" : { "x" : 2052, "y" : 1610 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2098, "y" : 1607 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2098, "y" : 1607 } } }, "connectors" : [ { "edgeId" : 133046, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2082, "y" : 1637 }, "to" : { "x" : 2091, "y" : 1648 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133044, "reactomeId" : 417891, "displayName" : "LPA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1914, "y" : 1674 }, "minX" : 1893, "maxX" : 2243, "minY" : 1641, "maxY" : 1690, "prop" : { "x" : 1893, "y" : 1659, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1899, "y" : 1664 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1931, "y" : 1664 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1931, "y" : 1664 } } }, "connectors" : [ { "edgeId" : 133042, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1927, "y" : 1656 }, "to" : { "x" : 1942, "y" : 1641 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133046, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1939, "y" : 1670 }, "to" : { "x" : 2091, "y" : 1648 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133049, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1939, "y" : 1673 }, "to" : { "x" : 2243, "y" : 1659 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133045, "reactomeId" : 10358086, "displayName" : "P2RY5:LPA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2012, "y" : 1620 }, "minX" : 1986, "maxX" : 2045, "minY" : 1594, "maxY" : 1640, "prop" : { "x" : 1986, "y" : 1600, "width" : 53, "height" : 40 }, "textPosition" : { "x" : 1987, "y" : 1605 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2039, "y" : 1600 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2039, "y" : 1600 } } }, "connectors" : [ { "edgeId" : 133042, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133050, "reactomeId" : 10358102, "displayName" : "P2RY10", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2231, "y" : 1619 }, "minX" : 2202, "maxX" : 2266, "minY" : 1600, "maxY" : 1659, "prop" : { "x" : 2202, "y" : 1606, "width" : 58, "height" : 27 }, "textPosition" : { "x" : 2203, "y" : 1609 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2260, "y" : 1606 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2260, "y" : 1606 } } }, "connectors" : [ { "edgeId" : 133049, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2235, "y" : 1636 }, "to" : { "x" : 2243, "y" : 1659 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133051, "reactomeId" : 10358104, "displayName" : "P2RY10:LPA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2310, "y" : 1619 }, "minX" : 2281, "maxX" : 2345, "minY" : 1595, "maxY" : 1638, "prop" : { "x" : 2281, "y" : 1601, "width" : 58, "height" : 37 }, "textPosition" : { "x" : 2282, "y" : 1603 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2339, "y" : 1601 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2339, "y" : 1601 } } }, "connectors" : [ { "edgeId" : 133049, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133048, "reactomeId" : 10358098, "displayName" : "P2RY9:LPA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2160, "y" : 1617 }, "minX" : 2131, "maxX" : 2196, "minY" : 1592, "maxY" : 1636, "prop" : { "x" : 2131, "y" : 1598, "width" : 59, "height" : 38 }, "textPosition" : { "x" : 2135, "y" : 1601 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2190, "y" : 1598 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2190, "y" : 1598 } } }, "connectors" : [ { "edgeId" : 133046, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133054, "reactomeId" : 417855, "displayName" : "UDP-Glc", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2591, "y" : 1671 }, "minX" : 2561, "maxX" : 2628, "minY" : 1650, "maxY" : 1685, "prop" : { "x" : 2561, "y" : 1657, "width" : 61, "height" : 28 }, "textPosition" : { "x" : 2563, "y" : 1660 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2617, "y" : 1662 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2617, "y" : 1662 } } }, "connectors" : [ { "edgeId" : 133052, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2615, "y" : 1654 }, "to" : { "x" : 2628, "y" : 1650 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133055, "reactomeId" : 10358659, "displayName" : "P2RY14:UDP-Glc", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2712, "y" : 1622 }, "minX" : 2675, "maxX" : 2755, "minY" : 1598, "maxY" : 1641, "prop" : { "x" : 2675, "y" : 1604, "width" : 74, "height" : 37 }, "textPosition" : { "x" : 2682, "y" : 1606 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2749, "y" : 1604 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2749, "y" : 1604 } } }, "connectors" : [ { "edgeId" : 133052, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133053, "reactomeId" : 10358657, "displayName" : "P2RY14", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2596, "y" : 1622 }, "minX" : 2568, "maxX" : 2631, "minY" : 1603, "maxY" : 1650, "prop" : { "x" : 2568, "y" : 1609, "width" : 57, "height" : 27 }, "textPosition" : { "x" : 2569, "y" : 1612 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2625, "y" : 1609 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2625, "y" : 1609 } } }, "connectors" : [ { "edgeId" : 133052, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2611, "y" : 1639 }, "to" : { "x" : 2628, "y" : 1650 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133058, "reactomeId" : 10358669, "displayName" : "ADORA1,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3651, "y" : 1620 }, "minX" : 3614, "maxX" : 3700, "minY" : 1607, "maxY" : 1645, "prop" : { "x" : 3614, "y" : 1607, "width" : 74, "height" : 27 }, "textPosition" : { "x" : 3616, "y" : 1610 }, "connectors" : [ { "edgeId" : 133056, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3677, "y" : 1640 }, "to" : { "x" : 3700, "y" : 1645 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133059, "reactomeId" : 10358671, "displayName" : "ADORA1,3:Ade-Rib", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3750, "y" : 1616 }, "minX" : 3712, "maxX" : 3795, "minY" : 1591, "maxY" : 1635, "prop" : { "x" : 3712, "y" : 1597, "width" : 77, "height" : 38 }, "textPosition" : { "x" : 3713, "y" : 1600 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3789, "y" : 1597 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3789, "y" : 1597 } } }, "connectors" : [ { "edgeId" : 133056, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133057, "reactomeId" : 83908, "displayName" : "Ade-Rib", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3660, "y" : 1671 }, "minX" : 3623, "maxX" : 3846, "minY" : 1645, "maxY" : 1687, "prop" : { "x" : 3623, "y" : 1656, "width" : 75, "height" : 31 }, "textPosition" : { "x" : 3633, "y" : 1661 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3693, "y" : 1661 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3693, "y" : 1661 } } }, "connectors" : [ { "edgeId" : 133056, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3683, "y" : 1653 }, "to" : { "x" : 3700, "y" : 1645 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133060, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3701, "y" : 1669 }, "to" : { "x" : 3846, "y" : 1663 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133062, "reactomeId" : 10357666, "displayName" : "ADORA2A,B:Ade-Rib", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3943, "y" : 1614 }, "minX" : 3898, "maxX" : 3994, "minY" : 1589, "maxY" : 1633, "prop" : { "x" : 3898, "y" : 1595, "width" : 90, "height" : 38 }, "textPosition" : { "x" : 3902, "y" : 1598 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3988, "y" : 1595 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3988, "y" : 1595 } } }, "connectors" : [ { "edgeId" : 133060, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133061, "reactomeId" : 10357664, "displayName" : "ADORA2A,B", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3839, "y" : 1617 }, "minX" : 3799, "maxX" : 3880, "minY" : 1602, "maxY" : 1663, "prop" : { "x" : 3799, "y" : 1602, "width" : 81, "height" : 30 }, "textPosition" : { "x" : 3800, "y" : 1606 }, "connectors" : [ { "edgeId" : 133060, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3841, "y" : 1638 }, "to" : { "x" : 3846, "y" : 1663 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133066, "reactomeId" : 10358687, "displayName" : "CNRs:Cannabinoids", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3333, "y" : 2475 }, "minX" : 3289, "maxX" : 3383, "minY" : 2450, "maxY" : 2495, "prop" : { "x" : 3289, "y" : 2456, "width" : 88, "height" : 39 }, "textPosition" : { "x" : 3290, "y" : 2446 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3377, "y" : 2456 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3377, "y" : 2456 } } }, "connectors" : [ { "edgeId" : 133063, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133064, "reactomeId" : 10358685, "displayName" : "CNRs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 3208, "y" : 2474 }, "minX" : 3146, "maxX" : 3288, "minY" : 2408, "maxY" : 2486, "prop" : { "x" : 3185, "y" : 2463, "width" : 46, "height" : 23 }, "textPosition" : { "x" : 3188, "y" : 2464 }, "connectors" : [ { "edgeId" : 133292, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3197, "y" : 2457 }, "to" : { "x" : 3146, "y" : 2408 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133063, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3227, "y" : 2457 }, "to" : { "x" : 3288, "y" : 2427 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133065, "reactomeId" : 444560, "displayName" : "Cannabinoids", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3287, "y" : 2376 }, "minX" : 3243, "maxX" : 3332, "minY" : 2364, "maxY" : 2427, "prop" : { "x" : 3243, "y" : 2364, "width" : 89, "height" : 25 }, "textPosition" : { "x" : 3244, "y" : 2359 }, "connectors" : [ { "edgeId" : 133063, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3287, "y" : 2395 }, "to" : { "x" : 3288, "y" : 2427 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133070, "reactomeId" : 10358342, "displayName" : "PAF receptor:PAF", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3021, "y" : 2229 }, "minX" : 2991, "maxX" : 3058, "minY" : 2197, "maxY" : 2256, "prop" : { "x" : 2991, "y" : 2203, "width" : 61, "height" : 53 }, "textPosition" : { "x" : 2993, "y" : 2207 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3052, "y" : 2203 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3052, "y" : 2203 } } }, "connectors" : [ { "edgeId" : 133067, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133068, "reactomeId" : 10358340, "displayName" : "PTAFR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2923, "y" : 2231 }, "minX" : 2893, "maxX" : 2959, "minY" : 2210, "maxY" : 2268, "prop" : { "x" : 2893, "y" : 2216, "width" : 60, "height" : 31 }, "textPosition" : { "x" : 2900, "y" : 2221 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2953, "y" : 2216 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2953, "y" : 2216 } } }, "connectors" : [ { "edgeId" : 133067, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2935, "y" : 2250 }, "to" : { "x" : 2954, "y" : 2268 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133069, "reactomeId" : 419375, "displayName" : "PAF", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2922, "y" : 2282 }, "minX" : 2903, "maxX" : 2954, "minY" : 2266, "maxY" : 2298, "prop" : { "x" : 2903, "y" : 2267, "width" : 38, "height" : 31 }, "textPosition" : { "x" : 2906, "y" : 2272 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2936, "y" : 2272 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2936, "y" : 2272 } } }, "connectors" : [ { "edgeId" : 133067, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2944, "y" : 2273 }, "to" : { "x" : 2954, "y" : 2268 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133074, "reactomeId" : 10358727, "displayName" : "Melatonin receptors:melatonin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 335, "y" : 1968 }, "minX" : 295, "maxX" : 382, "minY" : 1936, "maxY" : 1994, "prop" : { "x" : 295, "y" : 1942, "width" : 81, "height" : 52 }, "textPosition" : { "x" : 299, "y" : 1945 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 376, "y" : 1942 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 376, "y" : 1942 } } }, "connectors" : [ { "edgeId" : 133071, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133072, "reactomeId" : 10358725, "displayName" : "Melatonin receptors", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 217, "y" : 1975 }, "minX" : 159, "maxX" : 275, "minY" : 1941, "maxY" : 1990, "prop" : { "x" : 159, "y" : 1960, "width" : 116, "height" : 30 }, "textPosition" : { "x" : 180, "y" : 1958 }, "connectors" : [ { "edgeId" : 133071, "type" : "INPUT", "segments" : [ { "from" : { "x" : 228, "y" : 1954 }, "to" : { "x" : 244, "y" : 1941 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133073, "reactomeId" : 419339, "displayName" : "MLT", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 211, "y" : 1924 }, "minX" : 193, "maxX" : 244, "minY" : 1910, "maxY" : 1941, "prop" : { "x" : 193, "y" : 1911, "width" : 37, "height" : 27 }, "textPosition" : { "x" : 196, "y" : 1914 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 225, "y" : 1916 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 225, "y" : 1916 } } }, "connectors" : [ { "edgeId" : 133071, "type" : "INPUT", "segments" : [ { "from" : { "x" : 233, "y" : 1933 }, "to" : { "x" : 244, "y" : 1941 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133078, "reactomeId" : 10358212, "displayName" : "LPAR1,2,3,5:LPA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2166, "y" : 1972 }, "minX" : 2111, "maxX" : 2228, "minY" : 1953, "maxY" : 1986, "prop" : { "x" : 2111, "y" : 1959, "width" : 111, "height" : 27 }, "textPosition" : { "x" : 2112, "y" : 1965 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2222, "y" : 1959 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2222, "y" : 1959 } } }, "connectors" : [ { "edgeId" : 133075, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133076, "reactomeId" : 10358210, "displayName" : "LPAR1,2,3,5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2017, "y" : 1973 }, "minX" : 1965, "maxX" : 2069, "minY" : 1932, "maxY" : 1986, "prop" : { "x" : 1965, "y" : 1960, "width" : 104, "height" : 26 }, "textPosition" : { "x" : 1976, "y" : 1962 }, "connectors" : [ { "edgeId" : 133075, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2029, "y" : 1954 }, "to" : { "x" : 2057, "y" : 1932 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133077, "reactomeId" : 417891, "displayName" : "LPA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1994, "y" : 1919 }, "minX" : 1970, "maxX" : 2059, "minY" : 1903, "maxY" : 1934, "prop" : { "x" : 1970, "y" : 1904, "width" : 49, "height" : 30 }, "textPosition" : { "x" : 1979, "y" : 1908 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2014, "y" : 1909 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2014, "y" : 1909 } } }, "connectors" : [ { "edgeId" : 133166, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2022, "y" : 1915 }, "to" : { "x" : 2059, "y" : 1910 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133075, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2022, "y" : 1924 }, "to" : { "x" : 2057, "y" : 1932 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133082, "reactomeId" : 10358793, "displayName" : "S1PR2-5:S1P", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 673, "y" : 1971 }, "minX" : 626, "maxX" : 726, "minY" : 1953, "maxY" : 1983, "prop" : { "x" : 626, "y" : 1959, "width" : 94, "height" : 24 }, "textPosition" : { "x" : 629, "y" : 1962 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 720, "y" : 1959 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 720, "y" : 1959 } } }, "connectors" : [ { "edgeId" : 133079, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133080, "reactomeId" : 419305, "displayName" : "C18-S1P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 556, "y" : 1917 }, "minX" : 533, "maxX" : 603, "minY" : 1904, "maxY" : 1933, "prop" : { "x" : 533, "y" : 1905, "width" : 47, "height" : 24 }, "textPosition" : { "x" : 538, "y" : 1900 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 575, "y" : 1910 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 575, "y" : 1910 } } }, "connectors" : [ { "edgeId" : 133079, "type" : "INPUT", "segments" : [ { "from" : { "x" : 583, "y" : 1925 }, "to" : { "x" : 603, "y" : 1933 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133081, "reactomeId" : 10358791, "displayName" : "S1PR2-5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 562, "y" : 1973 }, "minX" : 522, "maxX" : 603, "minY" : 1933, "maxY" : 1983, "prop" : { "x" : 522, "y" : 1963, "width" : 80, "height" : 20 }, "textPosition" : { "x" : 532, "y" : 1963 }, "connectors" : [ { "edgeId" : 133079, "type" : "INPUT", "segments" : [ { "from" : { "x" : 572, "y" : 1957 }, "to" : { "x" : 603, "y" : 1933 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133086, "reactomeId" : 10362480, "displayName" : "Opsins:photon", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2599, "y" : 2015 }, "minX" : 2555, "maxX" : 2650, "minY" : 1992, "maxY" : 2032, "prop" : { "x" : 2555, "y" : 1998, "width" : 89, "height" : 34 }, "textPosition" : { "x" : 2572, "y" : 1997 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2644, "y" : 1998 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2644, "y" : 1998 } } }, "connectors" : [ { "edgeId" : 133083, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133084, "reactomeId" : 419777, "displayName" : "Photon", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2534, "y" : 1891 }, "minX" : 2505, "maxX" : 2693, "minY" : 1875, "maxY" : 1971, "prop" : { "x" : 2505, "y" : 1876, "width" : 58, "height" : 30 }, "textPosition" : { "x" : 2507, "y" : 1880 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2558, "y" : 1881 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2558, "y" : 1881 } } }, "connectors" : [ { "edgeId" : 133083, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2533, "y" : 1909 }, "to" : { "x" : 2532, "y" : 1971 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 133087, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2566, "y" : 1905 }, "to" : { "x" : 2693, "y" : 1971 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133085, "reactomeId" : 10362478, "displayName" : "Light-sensing opsins", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2493, "y" : 2015 }, "minX" : 2449, "maxX" : 2537, "minY" : 1971, "maxY" : 2033, "prop" : { "x" : 2449, "y" : 1998, "width" : 88, "height" : 35 }, "textPosition" : { "x" : 2462, "y" : 1991 }, "connectors" : [ { "edgeId" : 133083, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2508, "y" : 1992 }, "to" : { "x" : 2532, "y" : 1971 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133091, "reactomeId" : 400427, "displayName" : "FFAR1 ligands", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2876, "y" : 1898 }, "minX" : 2832, "maxX" : 2921, "minY" : 1886, "maxY" : 1927, "prop" : { "x" : 2832, "y" : 1886, "width" : 89, "height" : 25 }, "textPosition" : { "x" : 2850, "y" : 1881 }, "connectors" : [ { "edgeId" : 133090, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2885, "y" : 1917 }, "to" : { "x" : 2899, "y" : 1927 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133088, "reactomeId" : 10358108, "displayName" : "OPN4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2694, "y" : 2012 }, "minX" : 2668, "maxX" : 2727, "minY" : 1971, "maxY" : 2024, "prop" : { "x" : 2668, "y" : 2001, "width" : 53, "height" : 23 }, "textPosition" : { "x" : 2673, "y" : 2002 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2721, "y" : 2001 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2721, "y" : 2001 } } }, "connectors" : [ { "edgeId" : 133087, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2693, "y" : 1998 }, "to" : { "x" : 2693, "y" : 1971 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133089, "reactomeId" : 10358110, "displayName" : "Melanospin:photon", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2784, "y" : 2015 }, "minX" : 2740, "maxX" : 2835, "minY" : 1991, "maxY" : 2034, "prop" : { "x" : 2740, "y" : 1997, "width" : 89, "height" : 37 }, "textPosition" : { "x" : 2743, "y" : 1999 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2829, "y" : 1997 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2829, "y" : 1997 } } }, "connectors" : [ { "edgeId" : 133087, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133095, "reactomeId" : 10358408, "displayName" : "GPR43", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3096, "y" : 1964 }, "minX" : 3064, "maxX" : 3145, "minY" : 1931, "maxY" : 1979, "prop" : { "x" : 3064, "y" : 1949, "width" : 65, "height" : 30 }, "textPosition" : { "x" : 3072, "y" : 1953 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3129, "y" : 1949 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3129, "y" : 1949 } } }, "connectors" : [ { "edgeId" : 133094, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3118, "y" : 1946 }, "to" : { "x" : 3145, "y" : 1931 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133092, "reactomeId" : 10358402, "displayName" : "FFAR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2874, "y" : 1966 }, "minX" : 2845, "maxX" : 2909, "minY" : 1927, "maxY" : 1984, "prop" : { "x" : 2845, "y" : 1948, "width" : 58, "height" : 36 }, "textPosition" : { "x" : 2851, "y" : 1955 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2903, "y" : 1948 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2903, "y" : 1948 } } }, "connectors" : [ { "edgeId" : 133090, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2885, "y" : 1945 }, "to" : { "x" : 2899, "y" : 1927 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133093, "reactomeId" : 10358404, "displayName" : "FFAR1:FFAR1 ligands", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2982, "y" : 1965 }, "minX" : 2936, "maxX" : 3034, "minY" : 1942, "maxY" : 1983, "prop" : { "x" : 2936, "y" : 1948, "width" : 92, "height" : 35 }, "textPosition" : { "x" : 2936, "y" : 1948 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3028, "y" : 1948 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3028, "y" : 1948 } } }, "connectors" : [ { "edgeId" : 133090, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133099, "reactomeId" : 444074, "displayName" : "FFAR3 ligands", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3340, "y" : 1905 }, "minX" : 3307, "maxX" : 3397, "minY" : 1888, "maxY" : 1925, "prop" : { "x" : 3307, "y" : 1888, "width" : 66, "height" : 35 }, "textPosition" : { "x" : 3313, "y" : 1888 }, "connectors" : [ { "edgeId" : 133098, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3379, "y" : 1916 }, "to" : { "x" : 3397, "y" : 1925 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133096, "reactomeId" : 444210, "displayName" : "FFAR2 ligands", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3094, "y" : 1899 }, "minX" : 3058, "maxX" : 3145, "minY" : 1881, "maxY" : 1931, "prop" : { "x" : 3058, "y" : 1881, "width" : 72, "height" : 36 }, "textPosition" : { "x" : 3067, "y" : 1881 }, "connectors" : [ { "edgeId" : 133094, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3122, "y" : 1923 }, "to" : { "x" : 3145, "y" : 1931 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133097, "reactomeId" : 10358410, "displayName" : "FFAR2:FFAR2 ligands", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3236, "y" : 1963 }, "minX" : 3194, "maxX" : 3285, "minY" : 1938, "maxY" : 1983, "prop" : { "x" : 3194, "y" : 1944, "width" : 85, "height" : 39 }, "textPosition" : { "x" : 3210, "y" : 1934 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3279, "y" : 1944 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3279, "y" : 1944 } } }, "connectors" : [ { "edgeId" : 133094, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133103, "reactomeId" : 351626, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2702, "y" : 2281 }, "minX" : 2686, "maxX" : 2740, "minY" : 2265, "maxY" : 2297, "prop" : { "x" : 2686, "y" : 2266, "width" : 32, "height" : 31 }, "textPosition" : { "x" : 2688, "y" : 2271 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2713, "y" : 2271 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2713, "y" : 2271 } } }, "connectors" : [ { "edgeId" : 133102, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2721, "y" : 2275 }, "to" : { "x" : 2740, "y" : 2269 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 133100, "reactomeId" : 10358414, "displayName" : "GPR41", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3336, "y" : 1965 }, "minX" : 3305, "maxX" : 3397, "minY" : 1925, "maxY" : 1979, "prop" : { "x" : 3305, "y" : 1952, "width" : 62, "height" : 27 }, "textPosition" : { "x" : 3311, "y" : 1955 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3367, "y" : 1952 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3367, "y" : 1952 } } }, "connectors" : [ { "edgeId" : 133098, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3356, "y" : 1949 }, "to" : { "x" : 3397, "y" : 1925 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133101, "reactomeId" : 10358416, "displayName" : "FFAR3:FFAR3 ligands", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3485, "y" : 1963 }, "minX" : 3442, "maxX" : 3534, "minY" : 1937, "maxY" : 1984, "prop" : { "x" : 3442, "y" : 1943, "width" : 86, "height" : 41 }, "textPosition" : { "x" : 3458, "y" : 1935 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3528, "y" : 1943 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3528, "y" : 1943 } } }, "connectors" : [ { "edgeId" : 133098, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133107, "reactomeId" : 10358923, "displayName" : "HCAR2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 821, "y" : 1970 }, "minX" : 789, "maxX" : 869, "minY" : 1929, "maxY" : 1981, "prop" : { "x" : 789, "y" : 1959, "width" : 64, "height" : 22 }, "textPosition" : { "x" : 796, "y" : 1959 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 853, "y" : 1959 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 853, "y" : 1959 } } }, "connectors" : [ { "edgeId" : 133106, "type" : "INPUT", "segments" : [ { "from" : { "x" : 833, "y" : 1956 }, "to" : { "x" : 869, "y" : 1929 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133104, "reactomeId" : 10358434, "displayName" : "pH sensing receptors", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2709, "y" : 2229 }, "minX" : 2666, "maxX" : 2753, "minY" : 2212, "maxY" : 2269, "prop" : { "x" : 2666, "y" : 2212, "width" : 87, "height" : 35 }, "textPosition" : { "x" : 2668, "y" : 2212 }, "connectors" : [ { "edgeId" : 133102, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2722, "y" : 2253 }, "to" : { "x" : 2740, "y" : 2269 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133105, "reactomeId" : 10358436, "displayName" : "pH sensing receptors:H+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2821, "y" : 2230 }, "minX" : 2776, "maxX" : 2873, "minY" : 2205, "maxY" : 2250, "prop" : { "x" : 2776, "y" : 2211, "width" : 91, "height" : 39 }, "textPosition" : { "x" : 2780, "y" : 2201 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2867, "y" : 2211 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2867, "y" : 2211 } } }, "connectors" : [ { "edgeId" : 133102, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133111, "reactomeId" : 444840, "displayName" : "Bile acids", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2324, "y" : 1067 }, "minX" : 2289, "maxX" : 2372, "minY" : 1052, "maxY" : 1088, "prop" : { "x" : 2289, "y" : 1052, "width" : 70, "height" : 31 }, "textPosition" : { "x" : 2290, "y" : 1057 }, "connectors" : [ { "edgeId" : 133110, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2365, "y" : 1082 }, "to" : { "x" : 2372, "y" : 1088 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133108, "reactomeId" : 3296262, "displayName" : "HCAR2 ligands", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 818, "y" : 1899 }, "minX" : 764, "maxX" : 873, "minY" : 1884, "maxY" : 1929, "prop" : { "x" : 764, "y" : 1884, "width" : 109, "height" : 30 }, "textPosition" : { "x" : 769, "y" : 1888 }, "connectors" : [ { "edgeId" : 133106, "type" : "INPUT", "segments" : [ { "from" : { "x" : 843, "y" : 1920 }, "to" : { "x" : 869, "y" : 1929 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133109, "reactomeId" : 10358925, "displayName" : "HCAR2:HCAR2 ligands", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 959, "y" : 1969 }, "minX" : 903, "maxX" : 1021, "minY" : 1945, "maxY" : 1987, "prop" : { "x" : 903, "y" : 1951, "width" : 112, "height" : 36 }, "textPosition" : { "x" : 910, "y" : 1952 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1015, "y" : 1951 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1015, "y" : 1951 } } }, "connectors" : [ { "edgeId" : 133106, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133115, "reactomeId" : 158417, "displayName" : "Zn2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3112, "y" : 2268 }, "minX" : 3091, "maxX" : 3155, "minY" : 2248, "maxY" : 2284, "prop" : { "x" : 3091, "y" : 2253, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 3095, "y" : 2251 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3128, "y" : 2258 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3128, "y" : 2258 } } }, "connectors" : [ { "edgeId" : 133114, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3136, "y" : 2258 }, "to" : { "x" : 3155, "y" : 2248 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133112, "reactomeId" : 10357931, "displayName" : "GPBAR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2321, "y" : 1119 }, "minX" : 2292, "maxX" : 2372, "minY" : 1088, "maxY" : 1137, "prop" : { "x" : 2292, "y" : 1102, "width" : 59, "height" : 35 }, "textPosition" : { "x" : 2293, "y" : 1109 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2351, "y" : 1102 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2351, "y" : 1102 } } }, "connectors" : [ { "edgeId" : 133110, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2349, "y" : 1099 }, "to" : { "x" : 2372, "y" : 1088 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133113, "reactomeId" : 10357933, "displayName" : "GPBAR1: Bile acids", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2438, "y" : 1126 }, "minX" : 2383, "maxX" : 2499, "minY" : 1100, "maxY" : 1146, "prop" : { "x" : 2383, "y" : 1106, "width" : 110, "height" : 40 }, "textPosition" : { "x" : 2392, "y" : 1111 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2493, "y" : 1106 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2493, "y" : 1106 } } }, "connectors" : [ { "edgeId" : 133110, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133119, "reactomeId" : 517533, "displayName" : "NAGLY", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 605, "y" : 2283 }, "minX" : 574, "maxX" : 647, "minY" : 2256, "maxY" : 2298, "prop" : { "x" : 574, "y" : 2268, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 582, "y" : 2272 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 632, "y" : 2273 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 632, "y" : 2273 } } }, "connectors" : [ { "edgeId" : 133118, "type" : "INPUT", "segments" : [ { "from" : { "x" : 628, "y" : 2265 }, "to" : { "x" : 647, "y" : 2256 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133116, "reactomeId" : 10357971, "displayName" : "GPR39", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3113, "y" : 2231 }, "minX" : 3088, "maxX" : 3155, "minY" : 2214, "maxY" : 2248, "prop" : { "x" : 3088, "y" : 2220, "width" : 50, "height" : 22 }, "textPosition" : { "x" : 3088, "y" : 2220 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3138, "y" : 2220 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3138, "y" : 2220 } } }, "connectors" : [ { "edgeId" : 133114, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3141, "y" : 2241 }, "to" : { "x" : 3155, "y" : 2248 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133117, "reactomeId" : 10357973, "displayName" : "GPR39:Zn2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3238, "y" : 2226 }, "minX" : 3200, "maxX" : 3282, "minY" : 2203, "maxY" : 2244, "prop" : { "x" : 3200, "y" : 2209, "width" : 76, "height" : 35 }, "textPosition" : { "x" : 3211, "y" : 2209 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3276, "y" : 2209 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3276, "y" : 2209 } } }, "connectors" : [ { "edgeId" : 133114, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 132866, "reactomeId" : 10360464, "displayName" : "Two NPFF receptors can bind neuropeptide FF", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1983, "y" : 545 }, "minX" : 1962, "maxX" : 2011, "minY" : 539, "maxY" : 558, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1962, "y" : 545 }, "to" : { "x" : 1983, "y" : 545 } }, { "from" : { "x" : 1983, "y" : 545 }, "to" : { "x" : 2011, "y" : 558 } } ], "endShape" : { "a" : { "x" : 2003, "y" : 559 }, "b" : { "x" : 2011, "y" : 558 }, "c" : { "x" : 2006, "y" : 551 }, "type" : "ARROW", "centre" : { "x" : 2006, "y" : 551 } }, "reactionShape" : { "c" : { "x" : 1983, "y" : 545 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1983, "y" : 545 } }, "inputs" : [ { "id" : 132867, "points" : [ { "x" : 1934, "y" : 564 } ] }, { "id" : 132868, "points" : [ { "x" : 1938, "y" : 532 } ] } ], "outputs" : [ { "id" : 132869 } ] }, { "id" : 133122, "reactomeId" : 10370861, "displayName" : "C5AR2 binds anaphylatoxins and thier desArginated derivatives", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 711, "y" : 1799 }, "minX" : 691, "maxX" : 737, "minY" : 1793, "maxY" : 1805, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 691, "y" : 1799 }, "to" : { "x" : 711, "y" : 1799 } }, { "from" : { "x" : 711, "y" : 1799 }, "to" : { "x" : 737, "y" : 1793 } } ], "endShape" : { "a" : { "x" : 731, "y" : 1798 }, "b" : { "x" : 737, "y" : 1793 }, "c" : { "x" : 729, "y" : 1791 }, "type" : "ARROW", "centre" : { "x" : 729, "y" : 1791 } }, "reactionShape" : { "c" : { "x" : 711, "y" : 1799 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 711, "y" : 1799 } }, "inputs" : [ { "id" : 133123, "points" : [ { "x" : 681, "y" : 1794 } ] }, { "id" : 133124, "points" : [ { "x" : 666, "y" : 1815 } ] } ], "outputs" : [ { "id" : 133125 } ] }, { "id" : 132870, "reactomeId" : 10360456, "displayName" : "The orphan QRFP receptor can bind neuropeptide QRFP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2198, "y" : 547 }, "minX" : 2176, "maxX" : 2210, "minY" : 541, "maxY" : 557, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2176, "y" : 547 }, "to" : { "x" : 2198, "y" : 547 } }, { "from" : { "x" : 2198, "y" : 547 }, "to" : { "x" : 2210, "y" : 557 } } ], "endShape" : { "a" : { "x" : 2202, "y" : 556 }, "b" : { "x" : 2210, "y" : 557 }, "c" : { "x" : 2207, "y" : 549 }, "type" : "ARROW", "centre" : { "x" : 2207, "y" : 549 } }, "reactionShape" : { "c" : { "x" : 2198, "y" : 547 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2198, "y" : 547 } }, "inputs" : [ { "id" : 132871, "points" : [ { "x" : 2158, "y" : 561 } ] }, { "id" : 132872, "points" : [ { "x" : 2158, "y" : 536 } ] } ], "outputs" : [ { "id" : 132873 } ] }, { "id" : 133126, "reactomeId" : 10370812, "displayName" : "Melanin-concentrating hormone receptors bind MCH", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 932, "y" : 2241 }, "minX" : 912, "maxX" : 968, "minY" : 2235, "maxY" : 2247, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 912, "y" : 2240 }, "to" : { "x" : 932, "y" : 2241 } }, { "from" : { "x" : 932, "y" : 2241 }, "to" : { "x" : 968, "y" : 2237 } } ], "endShape" : { "a" : { "x" : 962, "y" : 2242 }, "b" : { "x" : 968, "y" : 2237 }, "c" : { "x" : 961, "y" : 2234 }, "type" : "ARROW", "centre" : { "x" : 961, "y" : 2234 } }, "reactionShape" : { "c" : { "x" : 932, "y" : 2241 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 932, "y" : 2241 } }, "inputs" : [ { "id" : 133127, "points" : [ { "x" : 897, "y" : 2233 } ] }, { "id" : 133128, "points" : [ { "x" : 880, "y" : 2255 } ] } ], "outputs" : [ { "id" : 133129 } ] }, { "id" : 132874, "reactomeId" : 10365127, "displayName" : "MLNR (GPR38) is a receptor for motilin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1282, "y" : 935 }, "minX" : 1264, "maxX" : 1301, "minY" : 925, "maxY" : 941, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1264, "y" : 933 }, "to" : { "x" : 1282, "y" : 935 } }, { "from" : { "x" : 1282, "y" : 935 }, "to" : { "x" : 1301, "y" : 925 } } ], "endShape" : { "a" : { "x" : 1297, "y" : 932 }, "b" : { "x" : 1301, "y" : 925 }, "c" : { "x" : 1293, "y" : 925 }, "type" : "ARROW", "centre" : { "x" : 1293, "y" : 925 } }, "reactionShape" : { "c" : { "x" : 1282, "y" : 935 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1282, "y" : 935 } }, "inputs" : [ { "id" : 132875, "points" : [ { "x" : 1253, "y" : 927 } ] }, { "id" : 132876, "points" : [ { "x" : 1256, "y" : 950 } ] } ], "outputs" : [ { "id" : 132877 } ] }, { "id" : 133130, "reactomeId" : 10370847, "displayName" : "Neuromedin-U receptors bind neuromedins U, S", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1237, "y" : 2262 }, "minX" : 1185, "maxX" : 1270, "minY" : 2250, "maxY" : 2268, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1185, "y" : 2261 }, "to" : { "x" : 1237, "y" : 2262 } }, { "from" : { "x" : 1237, "y" : 2262 }, "to" : { "x" : 1270, "y" : 2250 } } ], "endShape" : { "a" : { "x" : 1265, "y" : 2256 }, "b" : { "x" : 1270, "y" : 2250 }, "c" : { "x" : 1262, "y" : 2249 }, "type" : "ARROW", "centre" : { "x" : 1262, "y" : 2249 } }, "reactionShape" : { "c" : { "x" : 1237, "y" : 2262 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1237, "y" : 2262 } }, "inputs" : [ { "id" : 133131, "points" : [ { "x" : 1172, "y" : 2268 } ] }, { "id" : 133132, "points" : [ { "x" : 1173, "y" : 2253 } ] } ], "outputs" : [ { "id" : 133133 } ] }, { "id" : 133134, "reactomeId" : 10372764, "displayName" : "NMUR2 binds neuromedin-S", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1516, "y" : 2247 }, "minX" : 1491, "maxX" : 1542, "minY" : 2241, "maxY" : 2253, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1491, "y" : 2247 }, "to" : { "x" : 1516, "y" : 2247 } }, { "from" : { "x" : 1516, "y" : 2247 }, "to" : { "x" : 1542, "y" : 2241 } } ], "endShape" : { "a" : { "x" : 1536, "y" : 2246 }, "b" : { "x" : 1542, "y" : 2241 }, "c" : { "x" : 1534, "y" : 2239 }, "type" : "ARROW", "centre" : { "x" : 1534, "y" : 2239 } }, "reactionShape" : { "c" : { "x" : 1516, "y" : 2247 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1516, "y" : 2247 } }, "inputs" : [ { "id" : 133135, "points" : [ { "x" : 1480, "y" : 2246 } ] }, { "id" : 133136, "points" : [ { "x" : 1468, "y" : 2257 } ] } ], "outputs" : [ { "id" : 133137 } ] }, { "id" : 132878, "reactomeId" : 10365175, "displayName" : "Thyrotropin-releasing hormone receptor binds thyrotropin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 813, "y" : 931 }, "minX" : 793, "maxX" : 827, "minY" : 921, "maxY" : 937, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 793, "y" : 930 }, "to" : { "x" : 813, "y" : 931 } }, { "from" : { "x" : 813, "y" : 931 }, "to" : { "x" : 827, "y" : 921 } } ], "endShape" : { "a" : { "x" : 824, "y" : 928 }, "b" : { "x" : 827, "y" : 921 }, "c" : { "x" : 819, "y" : 922 }, "type" : "ARROW", "centre" : { "x" : 819, "y" : 922 } }, "reactionShape" : { "c" : { "x" : 813, "y" : 931 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 813, "y" : 931 } }, "inputs" : [ { "id" : 132879, "points" : [ { "x" : 782, "y" : 926 } ] }, { "id" : 132880, "points" : [ { "x" : 785, "y" : 939 } ] } ], "outputs" : [ { "id" : 132881 } ] }, { "id" : 132882, "reactomeId" : 10365183, "displayName" : "Neuropeptide S receptor binds neuropeptide S", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 410, "y" : 551 }, "minX" : 394, "maxX" : 435, "minY" : 545, "maxY" : 564, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 394, "y" : 551 }, "to" : { "x" : 410, "y" : 551 } }, { "from" : { "x" : 410, "y" : 551 }, "to" : { "x" : 435, "y" : 564 } } ], "endShape" : { "a" : { "x" : 427, "y" : 564 }, "b" : { "x" : 435, "y" : 564 }, "c" : { "x" : 431, "y" : 557 }, "type" : "ARROW", "centre" : { "x" : 431, "y" : 557 } }, "reactionShape" : { "c" : { "x" : 410, "y" : 551 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 410, "y" : 551 } }, "inputs" : [ { "id" : 132883, "points" : [ { "x" : 385, "y" : 543 } ] }, { "id" : 132884, "points" : [ { "x" : 379, "y" : 560 } ] } ], "outputs" : [ { "id" : 132885 } ] }, { "id" : 133138, "reactomeId" : 10392649, "displayName" : "HCAR1 binds LACT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1476, "y" : 1930 }, "minX" : 1452, "maxX" : 1505, "minY" : 1924, "maxY" : 1958, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1452, "y" : 1929 }, "to" : { "x" : 1476, "y" : 1930 } }, { "from" : { "x" : 1476, "y" : 1930 }, "to" : { "x" : 1505, "y" : 1958 } } ], "endShape" : { "a" : { "x" : 1497, "y" : 1956 }, "b" : { "x" : 1505, "y" : 1958 }, "c" : { "x" : 1503, "y" : 1950 }, "type" : "ARROW", "centre" : { "x" : 1503, "y" : 1950 } }, "reactionShape" : { "c" : { "x" : 1476, "y" : 1930 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1476, "y" : 1930 } }, "inputs" : [ { "id" : 133139, "points" : [ { "x" : 1434, "y" : 1916 } ] }, { "id" : 133140, "points" : [ { "x" : 1426, "y" : 1955 } ] } ], "outputs" : [ { "id" : 133141 } ] }, { "id" : 132886, "reactomeId" : 10365191, "displayName" : "Prokineticin receptors bind prokineticin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1032, "y" : 934 }, "minX" : 1014, "maxX" : 1047, "minY" : 928, "maxY" : 940, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1014, "y" : 934 }, "to" : { "x" : 1032, "y" : 934 } }, { "from" : { "x" : 1032, "y" : 934 }, "to" : { "x" : 1047, "y" : 928 } } ], "endShape" : { "a" : { "x" : 1042, "y" : 934 }, "b" : { "x" : 1047, "y" : 928 }, "c" : { "x" : 1039, "y" : 927 }, "type" : "ARROW", "centre" : { "x" : 1039, "y" : 927 } }, "reactionShape" : { "c" : { "x" : 1032, "y" : 934 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1032, "y" : 934 } }, "inputs" : [ { "id" : 132887, "points" : [ { "x" : 990, "y" : 942 } ] }, { "id" : 132888, "points" : [ { "x" : 1001, "y" : 924 } ] } ], "outputs" : [ { "id" : 132889 } ] }, { "id" : 133142, "reactomeId" : 10392647, "displayName" : "HCAR3 binds HCAR3 ligands", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1165, "y" : 1929 }, "minX" : 1135, "maxX" : 1192, "minY" : 1923, "maxY" : 1946, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1135, "y" : 1930 }, "to" : { "x" : 1165, "y" : 1929 } }, { "from" : { "x" : 1165, "y" : 1929 }, "to" : { "x" : 1192, "y" : 1946 } } ], "endShape" : { "a" : { "x" : 1184, "y" : 1946 }, "b" : { "x" : 1192, "y" : 1946 }, "c" : { "x" : 1188, "y" : 1939 }, "type" : "ARROW", "centre" : { "x" : 1188, "y" : 1939 } }, "reactionShape" : { "c" : { "x" : 1165, "y" : 1929 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1165, "y" : 1929 } }, "inputs" : [ { "id" : 133143, "points" : [ { "x" : 1105, "y" : 1954 } ] }, { "id" : 133144, "points" : [ { "x" : 1112, "y" : 1925 } ] } ], "outputs" : [ { "id" : 133145 } ] }, { "id" : 132890, "reactomeId" : 10365219, "displayName" : "Relaxin receptor 1 binds relaxin 2 and 3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 441, "y" : 946 }, "minX" : 416, "maxX" : 455, "minY" : 937, "maxY" : 952, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 416, "y" : 945 }, "to" : { "x" : 441, "y" : 946 } }, { "from" : { "x" : 441, "y" : 946 }, "to" : { "x" : 455, "y" : 937 } } ], "endShape" : { "a" : { "x" : 451, "y" : 944 }, "b" : { "x" : 455, "y" : 937 }, "c" : { "x" : 447, "y" : 937 }, "type" : "ARROW", "centre" : { "x" : 447, "y" : 937 } }, "reactionShape" : { "c" : { "x" : 441, "y" : 946 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 441, "y" : 946 } }, "inputs" : [ { "id" : 132891, "points" : [ { "x" : 401, "y" : 960 } ] }, { "id" : 132892, "points" : [ { "x" : 409, "y" : 929 } ] } ], "outputs" : [ { "id" : 132893 } ] }, { "id" : 133146, "reactomeId" : 10392645, "displayName" : "GPR31 is a receptor for 12(S)-HETE", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3882, "y" : 1945 }, "minX" : 3856, "maxX" : 3923, "minY" : 1939, "maxY" : 1960, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3856, "y" : 1945 }, "to" : { "x" : 3882, "y" : 1945 } }, { "from" : { "x" : 3882, "y" : 1945 }, "to" : { "x" : 3923, "y" : 1960 } } ], "endShape" : { "a" : { "x" : 3915, "y" : 1961 }, "b" : { "x" : 3923, "y" : 1960 }, "c" : { "x" : 3918, "y" : 1954 }, "type" : "ARROW", "centre" : { "x" : 3918, "y" : 1954 } }, "reactionShape" : { "c" : { "x" : 3882, "y" : 1945 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3882, "y" : 1945 } }, "inputs" : [ { "id" : 133147, "points" : [ { "x" : 3840, "y" : 1936 } ] }, { "id" : 133148, "points" : [ { "x" : 3833, "y" : 1961 } ] } ], "outputs" : [ { "id" : 133149 } ] }, { "id" : 133150, "reactomeId" : 10370845, "displayName" : "OXGR1 binds 2OG", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1754, "y" : 2252 }, "minX" : 1726, "maxX" : 1773, "minY" : 2244, "maxY" : 2258, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1726, "y" : 2251 }, "to" : { "x" : 1754, "y" : 2252 } }, { "from" : { "x" : 1754, "y" : 2252 }, "to" : { "x" : 1773, "y" : 2244 } } ], "endShape" : { "a" : { "x" : 1768, "y" : 2250 }, "b" : { "x" : 1773, "y" : 2244 }, "c" : { "x" : 1765, "y" : 2243 }, "type" : "ARROW", "centre" : { "x" : 1765, "y" : 2243 } }, "reactionShape" : { "c" : { "x" : 1754, "y" : 2252 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1754, "y" : 2252 } }, "inputs" : [ { "id" : 133151, "points" : [ { "x" : 1709, "y" : 2270 } ] }, { "id" : 133152, "points" : [ { "x" : 1710, "y" : 2244 } ] } ], "outputs" : [ { "id" : 133153 } ] }, { "id" : 132894, "reactomeId" : 10365223, "displayName" : "Relaxin receptor 2 binds relaxin 2 and INSL3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 616, "y" : 941 }, "minX" : 598, "maxX" : 633, "minY" : 935, "maxY" : 947, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 598, "y" : 940 }, "to" : { "x" : 616, "y" : 941 } }, { "from" : { "x" : 616, "y" : 941 }, "to" : { "x" : 633, "y" : 936 } } ], "endShape" : { "a" : { "x" : 627, "y" : 942 }, "b" : { "x" : 633, "y" : 936 }, "c" : { "x" : 625, "y" : 934 }, "type" : "ARROW", "centre" : { "x" : 625, "y" : 934 } }, "reactionShape" : { "c" : { "x" : 616, "y" : 941 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 616, "y" : 941 } }, "inputs" : [ { "id" : 132895, "points" : [ { "x" : 586, "y" : 928 } ] }, { "id" : 132896, "points" : [ { "x" : 589, "y" : 954 } ] } ], "outputs" : [ { "id" : 132897 } ] }, { "id" : 133154, "reactomeId" : 10392635, "displayName" : "SUCNR1 binds SUCCA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2073, "y" : 2240 }, "minX" : 2044, "maxX" : 2108, "minY" : 2234, "maxY" : 2246, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2044, "y" : 2239 }, "to" : { "x" : 2073, "y" : 2240 } }, { "from" : { "x" : 2073, "y" : 2240 }, "to" : { "x" : 2108, "y" : 2235 } } ], "endShape" : { "a" : { "x" : 2102, "y" : 2240 }, "b" : { "x" : 2108, "y" : 2235 }, "c" : { "x" : 2101, "y" : 2232 }, "type" : "ARROW", "centre" : { "x" : 2101, "y" : 2232 } }, "reactionShape" : { "c" : { "x" : 2073, "y" : 2240 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2073, "y" : 2240 } }, "inputs" : [ { "id" : 133155, "points" : [ { "x" : 2035, "y" : 2236 } ] }, { "id" : 133156, "points" : [ { "x" : 2021, "y" : 2247 } ] } ], "outputs" : [ { "id" : 133157 } ] }, { "id" : 132898, "reactomeId" : 10365221, "displayName" : "Relaxin 3 receptor 1 binds relaxin 3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3701, "y" : 931 }, "minX" : 3682, "maxX" : 3729, "minY" : 925, "maxY" : 937, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3682, "y" : 932 }, "to" : { "x" : 3701, "y" : 931 } }, { "from" : { "x" : 3701, "y" : 931 }, "to" : { "x" : 3729, "y" : 925 } } ], "endShape" : { "a" : { "x" : 3723, "y" : 930 }, "b" : { "x" : 3729, "y" : 925 }, "c" : { "x" : 3721, "y" : 923 }, "type" : "ARROW", "centre" : { "x" : 3721, "y" : 923 } }, "reactionShape" : { "c" : { "x" : 3701, "y" : 931 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3701, "y" : 931 } }, "inputs" : [ { "id" : 132899, "points" : [ { "x" : 3656, "y" : 947 } ] }, { "id" : 132900, "points" : [ { "x" : 3661, "y" : 922 } ] } ], "outputs" : [ { "id" : 132901 } ] }, { "id" : 132902, "reactomeId" : 10360921, "displayName" : "CHRM2,4 bind acetylcholine", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3300, "y" : 2765 }, "minX" : 3268, "maxX" : 3306, "minY" : 2732, "maxY" : 2771, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3300, "y" : 2766 }, "to" : { "x" : 3300, "y" : 2765 } }, { "from" : { "x" : 3300, "y" : 2765 }, "to" : { "x" : 3268, "y" : 2732 } } ], "endShape" : { "a" : { "x" : 3276, "y" : 2734 }, "b" : { "x" : 3268, "y" : 2732 }, "c" : { "x" : 3270, "y" : 2740 }, "type" : "ARROW", "centre" : { "x" : 3270, "y" : 2740 } }, "reactionShape" : { "c" : { "x" : 3300, "y" : 2765 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3300, "y" : 2765 } }, "inputs" : [ { "id" : 132903, "points" : [ { "x" : 3325, "y" : 2727 } ] }, { "id" : 132904, "points" : [ { "x" : 3300, "y" : 2794 } ] } ], "outputs" : [ { "id" : 132905 } ] }, { "id" : 133158, "reactomeId" : 10392643, "displayName" : "CCRL2 binds CCL19", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3720, "y" : 60 }, "minX" : 3695, "maxX" : 3744, "minY" : 54, "maxY" : 74, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3695, "y" : 60 }, "to" : { "x" : 3720, "y" : 60 } }, { "from" : { "x" : 3720, "y" : 60 }, "to" : { "x" : 3744, "y" : 74 } } ], "endShape" : { "a" : { "x" : 3736, "y" : 74 }, "b" : { "x" : 3744, "y" : 74 }, "c" : { "x" : 3740, "y" : 67 }, "type" : "ARROW", "centre" : { "x" : 3740, "y" : 67 } }, "reactionShape" : { "c" : { "x" : 3720, "y" : 60 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3720, "y" : 60 } }, "inputs" : [ { "id" : 133159, "points" : [ { "x" : 3680, "y" : 53 } ] }, { "id" : 133160, "points" : [ { "x" : 3683, "y" : 71 } ] } ], "outputs" : [ { "id" : 133161 } ] }, { "id" : 133162, "reactomeId" : 10399128, "displayName" : "GPR37 binds prosaptide", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 222, "y" : 2263 }, "minX" : 202, "maxX" : 245, "minY" : 2253, "maxY" : 2269, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 202, "y" : 2263 }, "to" : { "x" : 222, "y" : 2263 } }, { "from" : { "x" : 222, "y" : 2263 }, "to" : { "x" : 245, "y" : 2253 } } ], "endShape" : { "a" : { "x" : 240, "y" : 2259 }, "b" : { "x" : 245, "y" : 2253 }, "c" : { "x" : 237, "y" : 2252 }, "type" : "ARROW", "centre" : { "x" : 237, "y" : 2252 } }, "reactionShape" : { "c" : { "x" : 222, "y" : 2263 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 222, "y" : 2263 } }, "inputs" : [ { "id" : 133163, "points" : [ { "x" : 194, "y" : 2276 } ] }, { "id" : 133164, "points" : [ { "x" : 190, "y" : 2245 } ] } ], "outputs" : [ { "id" : 133165 } ] }, { "id" : 132906, "reactomeId" : 10360917, "displayName" : "CHRM1,3,5 bind acetylcholine", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 985, "y" : 2749 }, "minX" : 940, "maxX" : 991, "minY" : 2724, "maxY" : 2755, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 985, "y" : 2751 }, "to" : { "x" : 985, "y" : 2749 } }, { "from" : { "x" : 985, "y" : 2749 }, "to" : { "x" : 940, "y" : 2724 } } ], "endShape" : { "a" : { "x" : 948, "y" : 2724 }, "b" : { "x" : 940, "y" : 2724 }, "c" : { "x" : 944, "y" : 2731 }, "type" : "ARROW", "centre" : { "x" : 944, "y" : 2731 } }, "reactionShape" : { "c" : { "x" : 985, "y" : 2749 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 985, "y" : 2749 } }, "inputs" : [ { "id" : 132907, "points" : [ { "x" : 985, "y" : 2773 } ] }, { "id" : 132908, "points" : [ { "x" : 1016, "y" : 2725 } ] } ], "outputs" : [ { "id" : 132909 } ] }, { "id" : 133166, "reactomeId" : 10412161, "displayName" : "LRPP4(LRPP1-3,5) hydrolyse LPA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2089, "y" : 1910 }, "minX" : 2059, "maxX" : 2134, "minY" : 1904, "maxY" : 1916, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2059, "y" : 1910 }, "to" : { "x" : 2089, "y" : 1910 } }, { "from" : { "x" : 2089, "y" : 1910 }, "to" : { "x" : 2134, "y" : 1910 } } ], "reactionShape" : { "a" : { "x" : 2083, "y" : 1904 }, "b" : { "x" : 2095, "y" : 1916 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2089, "y" : 1910 } }, "inputs" : [ { "id" : 133167, "points" : [ { "x" : 2012, "y" : 1888 } ] }, { "id" : 133077, "points" : [ { "x" : 2022, "y" : 1915 } ] } ], "outputs" : [ { "id" : 133168, "points" : [ { "x" : 2170, "y" : 1872 } ] }, { "id" : 133169, "points" : [ { "x" : 2160, "y" : 1915 } ] } ], "catalysts" : [ { "id" : 133170, "points" : [ { "x" : 2089, "y" : 1875 } ] } ] }, { "id" : 132910, "reactomeId" : 10360913, "displayName" : "ADRA1A,B,D bind ADR,NAd", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2215, "y" : 1000 }, "minX" : 2209, "maxX" : 2221, "minY" : 932, "maxY" : 1006, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2217, "y" : 1000 }, "to" : { "x" : 2215, "y" : 1000 } }, { "from" : { "x" : 2215, "y" : 1000 }, "to" : { "x" : 2215, "y" : 932 } } ], "endShape" : { "a" : { "x" : 2219, "y" : 939 }, "b" : { "x" : 2215, "y" : 932 }, "c" : { "x" : 2211, "y" : 939 }, "type" : "ARROW", "centre" : { "x" : 2211, "y" : 939 } }, "reactionShape" : { "c" : { "x" : 2215, "y" : 1000 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2215, "y" : 1000 } }, "inputs" : [ { "id" : 132911, "points" : [ { "x" : 2011, "y" : 929 } ] }, { "id" : 132912, "points" : [ { "x" : 2250, "y" : 1000 } ] } ], "outputs" : [ { "id" : 132913 } ], "inhibitors" : [ { "id" : 132915, "points" : [ { "x" : 1881, "y" : 933 }, { "x" : 1920, "y" : 959 } ] } ], "activators" : [ { "id" : 132914, "points" : [ { "x" : 2127, "y" : 934 } ] } ] }, { "id" : 133171, "reactomeId" : 10420279, "displayName" : "GPR143 binds L-Dopa", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1712, "y" : 945 }, "minX" : 1706, "maxX" : 1739, "minY" : 930, "maxY" : 951, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1712, "y" : 944 }, "to" : { "x" : 1712, "y" : 945 } }, { "from" : { "x" : 1712, "y" : 945 }, "to" : { "x" : 1739, "y" : 930 } } ], "endShape" : { "a" : { "x" : 1735, "y" : 937 }, "b" : { "x" : 1739, "y" : 930 }, "c" : { "x" : 1731, "y" : 930 }, "type" : "ARROW", "centre" : { "x" : 1731, "y" : 930 } }, "reactionShape" : { "c" : { "x" : 1712, "y" : 945 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1712, "y" : 945 } }, "inputs" : [ { "id" : 133172, "points" : [ { "x" : 1668, "y" : 991 } ] }, { "id" : 133173, "points" : [ { "x" : 1693, "y" : 926 } ] } ], "outputs" : [ { "id" : 133174 } ] }, { "id" : 133175, "reactomeId" : 10420281, "displayName" : "CCR8 binds CCL1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2566, "y" : 401 }, "minX" : 2545, "maxX" : 2588, "minY" : 378, "maxY" : 407, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2545, "y" : 402 }, "to" : { "x" : 2566, "y" : 401 } }, { "from" : { "x" : 2566, "y" : 401 }, "to" : { "x" : 2588, "y" : 378 } } ], "endShape" : { "a" : { "x" : 2586, "y" : 386 }, "b" : { "x" : 2588, "y" : 378 }, "c" : { "x" : 2580, "y" : 380 }, "type" : "ARROW", "centre" : { "x" : 2580, "y" : 380 } }, "reactionShape" : { "c" : { "x" : 2566, "y" : 401 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2566, "y" : 401 } }, "inputs" : [ { "id" : 133176, "points" : [ { "x" : 2531, "y" : 409 } ] }, { "id" : 133177, "points" : [ { "x" : 2520, "y" : 386 } ] } ], "outputs" : [ { "id" : 133178 } ] }, { "id" : 132919, "reactomeId" : 10360933, "displayName" : "ADRB1 bind ADR,NAd", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 4114, "y" : 1301 }, "minX" : 4089, "maxX" : 4120, "minY" : 1295, "maxY" : 1307, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 4113, "y" : 1300 }, "to" : { "x" : 4114, "y" : 1302 } }, { "from" : { "x" : 4114, "y" : 1302 }, "to" : { "x" : 4114, "y" : 1301 } }, { "from" : { "x" : 4114, "y" : 1301 }, "to" : { "x" : 4089, "y" : 1301 } } ], "endShape" : { "a" : { "x" : 4096, "y" : 1297 }, "b" : { "x" : 4089, "y" : 1301 }, "c" : { "x" : 4096, "y" : 1305 }, "type" : "ARROW", "centre" : { "x" : 4096, "y" : 1305 } }, "reactionShape" : { "c" : { "x" : 4114, "y" : 1301 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 4114, "y" : 1301 } }, "inputs" : [ { "id" : 132920, "points" : [ { "x" : 4178, "y" : 1300 } ] }, { "id" : 132921, "points" : [ { "x" : 4067, "y" : 1270 } ] } ], "outputs" : [ { "id" : 132922 } ], "inhibitors" : [ { "id" : 132925, "points" : [ { "x" : 4083, "y" : 1353 }, { "x" : 4113, "y" : 1353 } ] } ], "activators" : [ { "id" : 132923, "points" : [ { "x" : 4080, "y" : 1453 }, { "x" : 4143, "y" : 1453 } ] }, { "id" : 132924, "points" : [ { "x" : 4072, "y" : 1232 }, { "x" : 4114, "y" : 1256 } ] } ] }, { "id" : 132916, "reactomeId" : 10360919, "displayName" : "ADRA2A,B,C bind ADR,NAd", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2353, "y" : 1001 }, "minX" : 2347, "maxX" : 2477, "minY" : 930, "maxY" : 1007, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2353, "y" : 1000 }, "to" : { "x" : 2353, "y" : 1001 } }, { "from" : { "x" : 2353, "y" : 1001 }, "to" : { "x" : 2477, "y" : 930 } } ], "endShape" : { "a" : { "x" : 2473, "y" : 937 }, "b" : { "x" : 2477, "y" : 930 }, "c" : { "x" : 2469, "y" : 930 }, "type" : "ARROW", "centre" : { "x" : 2469, "y" : 930 } }, "reactionShape" : { "c" : { "x" : 2353, "y" : 1001 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2353, "y" : 1001 } }, "inputs" : [ { "id" : 132917, "points" : [ { "x" : 2353, "y" : 935 } ] }, { "id" : 132912, "points" : [ { "x" : 2332, "y" : 1000 } ] } ], "outputs" : [ { "id" : 132918 } ] }, { "id" : 133179, "reactomeId" : 10421822, "displayName" : "CCR2, CCR3 bind CCL13", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2161, "y" : 411 }, "minX" : 2137, "maxX" : 2188, "minY" : 390, "maxY" : 417, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2137, "y" : 410 }, "to" : { "x" : 2161, "y" : 411 } }, { "from" : { "x" : 2161, "y" : 411 }, "to" : { "x" : 2188, "y" : 390 } } ], "endShape" : { "a" : { "x" : 2185, "y" : 397 }, "b" : { "x" : 2188, "y" : 390 }, "c" : { "x" : 2180, "y" : 391 }, "type" : "ARROW", "centre" : { "x" : 2180, "y" : 391 } }, "reactionShape" : { "c" : { "x" : 2161, "y" : 411 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2161, "y" : 411 } }, "inputs" : [ { "id" : 133180, "points" : [ { "x" : 2110, "y" : 389 } ] }, { "id" : 133181, "points" : [ { "x" : 2116, "y" : 416 } ] } ], "outputs" : [ { "id" : 133182 } ] }, { "id" : 132926, "reactomeId" : 10360938, "displayName" : "DRD1,5 bind DA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 343, "y" : 1088 }, "minX" : 319, "maxX" : 364, "minY" : 1082, "maxY" : 1106, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 319, "y" : 1087 }, "to" : { "x" : 343, "y" : 1088 } }, { "from" : { "x" : 343, "y" : 1088 }, "to" : { "x" : 364, "y" : 1106 } } ], "endShape" : { "a" : { "x" : 356, "y" : 1105 }, "b" : { "x" : 364, "y" : 1106 }, "c" : { "x" : 361, "y" : 1098 }, "type" : "ARROW", "centre" : { "x" : 361, "y" : 1098 } }, "reactionShape" : { "c" : { "x" : 343, "y" : 1088 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 343, "y" : 1088 } }, "inputs" : [ { "id" : 132927, "points" : [ { "x" : 310, "y" : 1103 } ] }, { "id" : 132928, "points" : [ { "x" : 316, "y" : 1054 } ] } ], "outputs" : [ { "id" : 132929 } ] }, { "id" : 133183, "reactomeId" : 10420353, "displayName" : "GPR183 binds 7alpha,25-dihydroxycholesterol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1715, "y" : 1945 }, "minX" : 1684, "maxX" : 1750, "minY" : 1939, "maxY" : 1953, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1684, "y" : 1944 }, "to" : { "x" : 1715, "y" : 1945 } }, { "from" : { "x" : 1715, "y" : 1945 }, "to" : { "x" : 1750, "y" : 1953 } } ], "endShape" : { "a" : { "x" : 1742, "y" : 1955 }, "b" : { "x" : 1750, "y" : 1953 }, "c" : { "x" : 1744, "y" : 1948 }, "type" : "ARROW", "centre" : { "x" : 1744, "y" : 1948 } }, "reactionShape" : { "c" : { "x" : 1715, "y" : 1945 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1715, "y" : 1945 } }, "inputs" : [ { "id" : 133184, "points" : [ { "x" : 1675, "y" : 1959 } ] }, { "id" : 133185, "points" : [ { "x" : 1677, "y" : 1938 } ] } ], "outputs" : [ { "id" : 133186 } ] }, { "id" : 132930, "reactomeId" : 10360940, "displayName" : "D2D3,4 bind to DA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 523, "y" : 1087 }, "minX" : 495, "maxX" : 550, "minY" : 1081, "maxY" : 1103, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 495, "y" : 1085 }, "to" : { "x" : 523, "y" : 1087 } }, { "from" : { "x" : 523, "y" : 1087 }, "to" : { "x" : 550, "y" : 1103 } } ], "endShape" : { "a" : { "x" : 542, "y" : 1103 }, "b" : { "x" : 550, "y" : 1103 }, "c" : { "x" : 546, "y" : 1096 }, "type" : "ARROW", "centre" : { "x" : 546, "y" : 1096 } }, "reactionShape" : { "c" : { "x" : 523, "y" : 1087 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 523, "y" : 1087 } }, "inputs" : [ { "id" : 132928, "points" : [ { "x" : 336, "y" : 1040 } ] }, { "id" : 132931, "points" : [ { "x" : 483, "y" : 1102 } ] } ], "outputs" : [ { "id" : 132932 } ] }, { "id" : 133187, "reactomeId" : 10416183, "displayName" : "GPR35 binds kynurenic acid", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3411, "y" : 2255 }, "minX" : 3387, "maxX" : 3439, "minY" : 2246, "maxY" : 2261, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3387, "y" : 2254 }, "to" : { "x" : 3411, "y" : 2255 } }, { "from" : { "x" : 3411, "y" : 2255 }, "to" : { "x" : 3439, "y" : 2246 } } ], "endShape" : { "a" : { "x" : 3434, "y" : 2252 }, "b" : { "x" : 3439, "y" : 2246 }, "c" : { "x" : 3431, "y" : 2244 }, "type" : "ARROW", "centre" : { "x" : 3431, "y" : 2244 } }, "reactionShape" : { "c" : { "x" : 3411, "y" : 2255 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3411, "y" : 2255 } }, "inputs" : [ { "id" : 133188, "points" : [ { "x" : 3366, "y" : 2246 } ] }, { "id" : 133189, "points" : [ { "x" : 3366, "y" : 2266 } ] } ], "outputs" : [ { "id" : 133190 } ] }, { "id" : 133191, "reactomeId" : 10426137, "displayName" : "Neurolysin degrades neurotensin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1697, "y" : 509 }, "minX" : 1668, "maxX" : 1725, "minY" : 503, "maxY" : 515, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1668, "y" : 509 }, "to" : { "x" : 1697, "y" : 509 } }, { "from" : { "x" : 1697, "y" : 509 }, "to" : { "x" : 1725, "y" : 511 } } ], "reactionShape" : { "a" : { "x" : 1691, "y" : 503 }, "b" : { "x" : 1703, "y" : 515 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1697, "y" : 509 } }, "inputs" : [ { "id" : 132844 } ], "outputs" : [ { "id" : 133192, "points" : [ { "x" : 1749, "y" : 516 } ] }, { "id" : 133193, "points" : [ { "x" : 1764, "y" : 492 } ] } ], "catalysts" : [ { "id" : 133194, "points" : [ { "x" : 1697, "y" : 479 } ] } ] }, { "id" : 132933, "reactomeId" : 10360944, "displayName" : "HRH2 binds hist", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 577, "y" : 2733 }, "minX" : 562, "maxX" : 599, "minY" : 2726, "maxY" : 2747, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 593, "y" : 2741 }, "to" : { "x" : 577, "y" : 2733 } }, { "from" : { "x" : 577, "y" : 2733 }, "to" : { "x" : 562, "y" : 2726 } } ], "endShape" : { "a" : { "x" : 570, "y" : 2725 }, "b" : { "x" : 562, "y" : 2726 }, "c" : { "x" : 567, "y" : 2733 }, "type" : "ARROW", "centre" : { "x" : 567, "y" : 2733 } }, "reactionShape" : { "c" : { "x" : 577, "y" : 2733 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 577, "y" : 2733 } }, "inputs" : [ { "id" : 132934, "points" : [ { "x" : 613, "y" : 2718 } ] }, { "id" : 132935, "points" : [ { "x" : 593, "y" : 2798 } ] } ], "outputs" : [ { "id" : 132936 } ] }, { "id" : 133195, "reactomeId" : 10424246, "displayName" : "ECE1 cleaves EDN1(53-90)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1064, "y" : 509 }, "minX" : 1025, "maxX" : 1103, "minY" : 495, "maxY" : 529, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1103, "y" : 495 }, "to" : { "x" : 1064, "y" : 509 } }, { "from" : { "x" : 1064, "y" : 509 }, "to" : { "x" : 1025, "y" : 529 } } ], "endShape" : { "a" : { "x" : 1029, "y" : 522 }, "b" : { "x" : 1025, "y" : 529 }, "c" : { "x" : 1033, "y" : 529 }, "type" : "ARROW", "centre" : { "x" : 1033, "y" : 529 } }, "reactionShape" : { "a" : { "x" : 1058, "y" : 503 }, "b" : { "x" : 1070, "y" : 515 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1064, "y" : 509 } }, "inputs" : [ { "id" : 133196 } ], "outputs" : [ { "id" : 133197 } ], "catalysts" : [ { "id" : 133198, "points" : [ { "x" : 1063, "y" : 563 } ] } ] }, { "id" : 132937, "reactomeId" : 10360942, "displayName" : "HRH4 binds Hist", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2712, "y" : 2770 }, "minX" : 2699, "maxX" : 2718, "minY" : 2717, "maxY" : 2776, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2713, "y" : 2768 }, "to" : { "x" : 2712, "y" : 2770 } }, { "from" : { "x" : 2712, "y" : 2770 }, "to" : { "x" : 2699, "y" : 2717 } } ], "endShape" : { "a" : { "x" : 2705, "y" : 2723 }, "b" : { "x" : 2699, "y" : 2717 }, "c" : { "x" : 2697, "y" : 2725 }, "type" : "ARROW", "centre" : { "x" : 2697, "y" : 2725 } }, "reactionShape" : { "c" : { "x" : 2712, "y" : 2770 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2712, "y" : 2770 } }, "inputs" : [ { "id" : 132938, "points" : [ { "x" : 2775, "y" : 2714 } ] }, { "id" : 132939, "points" : [ { "x" : 2625, "y" : 2818 } ] } ], "outputs" : [ { "id" : 132940 } ] }, { "id" : 133199, "reactomeId" : 10424367, "displayName" : "ECE2 cleaves EDN1(53-90)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 904, "y" : 666 }, "minX" : 888, "maxX" : 938, "minY" : 660, "maxY" : 672, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 888, "y" : 666 }, "to" : { "x" : 904, "y" : 666 } }, { "from" : { "x" : 904, "y" : 666 }, "to" : { "x" : 938, "y" : 666 } } ], "endShape" : { "a" : { "x" : 931, "y" : 670 }, "b" : { "x" : 938, "y" : 666 }, "c" : { "x" : 931, "y" : 662 }, "type" : "ARROW", "centre" : { "x" : 931, "y" : 662 } }, "reactionShape" : { "a" : { "x" : 898, "y" : 660 }, "b" : { "x" : 910, "y" : 672 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 904, "y" : 666 } }, "inputs" : [ { "id" : 133200 } ], "outputs" : [ { "id" : 133201 } ], "catalysts" : [ { "id" : 133202, "points" : [ { "x" : 903, "y" : 637 } ] } ] }, { "id" : 132941, "reactomeId" : 10360946, "displayName" : "HTR1 and 5A receptors can bind serotonin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1103, "y" : 1080 }, "minX" : 1072, "maxX" : 1129, "minY" : 1074, "maxY" : 1102, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1072, "y" : 1080 }, "to" : { "x" : 1103, "y" : 1080 } }, { "from" : { "x" : 1103, "y" : 1080 }, "to" : { "x" : 1129, "y" : 1102 } } ], "endShape" : { "a" : { "x" : 1121, "y" : 1101 }, "b" : { "x" : 1129, "y" : 1102 }, "c" : { "x" : 1126, "y" : 1094 }, "type" : "ARROW", "centre" : { "x" : 1126, "y" : 1094 } }, "reactionShape" : { "c" : { "x" : 1103, "y" : 1080 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1103, "y" : 1080 } }, "inputs" : [ { "id" : 132942, "points" : [ { "x" : 1047, "y" : 1100 } ] }, { "id" : 132943, "points" : [ { "x" : 1177, "y" : 1032 } ] } ], "outputs" : [ { "id" : 132944 } ] }, { "id" : 133203, "reactomeId" : 10421820, "displayName" : "CMKLR1 binds Resolvin E1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3698, "y" : 2248 }, "minX" : 3642, "maxX" : 3735, "minY" : 2241, "maxY" : 2254, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3642, "y" : 2248 }, "to" : { "x" : 3698, "y" : 2248 } }, { "from" : { "x" : 3698, "y" : 2248 }, "to" : { "x" : 3735, "y" : 2241 } } ], "endShape" : { "a" : { "x" : 3729, "y" : 2246 }, "b" : { "x" : 3735, "y" : 2241 }, "c" : { "x" : 3727, "y" : 2238 }, "type" : "ARROW", "centre" : { "x" : 3727, "y" : 2238 } }, "reactionShape" : { "c" : { "x" : 3698, "y" : 2248 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3698, "y" : 2248 } }, "inputs" : [ { "id" : 133204, "points" : [ { "x" : 3617, "y" : 2267 } ] }, { "id" : 133205, "points" : [ { "x" : 3624, "y" : 2244 } ] } ], "outputs" : [ { "id" : 133206 } ] }, { "id" : 132689, "reactomeId" : 10356725, "displayName" : "AGT(25-32) binds to AGTR1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 440, "y" : 50 }, "minX" : 434, "maxX" : 473, "minY" : 44, "maxY" : 69, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 442, "y" : 51 }, "to" : { "x" : 440, "y" : 50 } }, { "from" : { "x" : 440, "y" : 50 }, "to" : { "x" : 473, "y" : 69 } } ], "endShape" : { "a" : { "x" : 465, "y" : 69 }, "b" : { "x" : 473, "y" : 69 }, "c" : { "x" : 469, "y" : 62 }, "type" : "ARROW", "centre" : { "x" : 469, "y" : 62 } }, "reactionShape" : { "c" : { "x" : 440, "y" : 50 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 440, "y" : 50 } }, "inputs" : [ { "id" : 132690, "points" : [ { "x" : 501, "y" : 38 } ] }, { "id" : 132691, "points" : [ { "x" : 409, "y" : 69 } ] } ], "outputs" : [ { "id" : 132692 } ], "inhibitors" : [ { "id" : 132693, "points" : [ { "x" : 335, "y" : 94 }, { "x" : 440, "y" : 115 } ] } ] }, { "id" : 132945, "reactomeId" : 10360948, "displayName" : "5-HT2 receptor can bind serotonin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1297, "y" : 1084 }, "minX" : 1263, "maxX" : 1329, "minY" : 1078, "maxY" : 1103, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1263, "y" : 1083 }, "to" : { "x" : 1297, "y" : 1084 } }, { "from" : { "x" : 1297, "y" : 1084 }, "to" : { "x" : 1329, "y" : 1103 } } ], "endShape" : { "a" : { "x" : 1321, "y" : 1103 }, "b" : { "x" : 1329, "y" : 1103 }, "c" : { "x" : 1325, "y" : 1096 }, "type" : "ARROW", "centre" : { "x" : 1325, "y" : 1096 } }, "reactionShape" : { "c" : { "x" : 1297, "y" : 1084 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1297, "y" : 1084 } }, "inputs" : [ { "id" : 132946, "points" : [ { "x" : 1261, "y" : 1104 } ] }, { "id" : 132943, "points" : [ { "x" : 1218, "y" : 1042 } ] } ], "outputs" : [ { "id" : 132947 } ] }, { "id" : 132694, "reactomeId" : 10356832, "displayName" : "Apelin receptor binds to apelin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3307, "y" : 66 }, "minX" : 3285, "maxX" : 3333, "minY" : 60, "maxY" : 73, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3285, "y" : 66 }, "to" : { "x" : 3307, "y" : 66 } }, { "from" : { "x" : 3307, "y" : 66 }, "to" : { "x" : 3333, "y" : 73 } } ], "endShape" : { "a" : { "x" : 3325, "y" : 75 }, "b" : { "x" : 3333, "y" : 73 }, "c" : { "x" : 3327, "y" : 67 }, "type" : "ARROW", "centre" : { "x" : 3327, "y" : 67 } }, "reactionShape" : { "c" : { "x" : 3307, "y" : 66 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3307, "y" : 66 } }, "inputs" : [ { "id" : 132695, "points" : [ { "x" : 3256, "y" : 76 } ] }, { "id" : 132696, "points" : [ { "x" : 3256, "y" : 59 } ] } ], "outputs" : [ { "id" : 132697 } ] }, { "id" : 133207, "reactomeId" : 10399130, "displayName" : "GPR37L binds prosaposin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 395, "y" : 2271 }, "minX" : 363, "maxX" : 442, "minY" : 2256, "maxY" : 2277, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 363, "y" : 2272 }, "to" : { "x" : 395, "y" : 2271 } }, { "from" : { "x" : 395, "y" : 2271 }, "to" : { "x" : 442, "y" : 2256 } } ], "endShape" : { "a" : { "x" : 437, "y" : 2262 }, "b" : { "x" : 442, "y" : 2256 }, "c" : { "x" : 434, "y" : 2254 }, "type" : "ARROW", "centre" : { "x" : 434, "y" : 2254 } }, "reactionShape" : { "c" : { "x" : 395, "y" : 2271 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 395, "y" : 2271 } }, "inputs" : [ { "id" : 133163, "points" : [ { "x" : 231, "y" : 2293 } ] }, { "id" : 133208, "points" : [ { "x" : 366, "y" : 2252 } ] } ], "outputs" : [ { "id" : 133209 } ] }, { "id" : 132951, "reactomeId" : 10361000, "displayName" : "Trace amine-associated receptors can bind trace amines", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2166, "y" : 1074 }, "minX" : 2144, "maxX" : 2191, "minY" : 1068, "maxY" : 1095, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2144, "y" : 1074 }, "to" : { "x" : 2166, "y" : 1074 } }, { "from" : { "x" : 2166, "y" : 1074 }, "to" : { "x" : 2191, "y" : 1095 } } ], "endShape" : { "a" : { "x" : 2183, "y" : 1094 }, "b" : { "x" : 2191, "y" : 1095 }, "c" : { "x" : 2188, "y" : 1087 }, "type" : "ARROW", "centre" : { "x" : 2188, "y" : 1087 } }, "reactionShape" : { "c" : { "x" : 2166, "y" : 1074 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2166, "y" : 1074 } }, "inputs" : [ { "id" : 132952, "points" : [ { "x" : 2123, "y" : 1091 } ] }, { "id" : 132953, "points" : [ { "x" : 2123, "y" : 1067 } ] } ], "outputs" : [ { "id" : 132954 } ] }, { "id" : 132948, "reactomeId" : 10360950, "displayName" : "5-HT4, 6 and 7 receptors can bind serotonin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1523, "y" : 1080 }, "minX" : 1492, "maxX" : 1548, "minY" : 1074, "maxY" : 1098, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1492, "y" : 1081 }, "to" : { "x" : 1523, "y" : 1080 } }, { "from" : { "x" : 1523, "y" : 1080 }, "to" : { "x" : 1548, "y" : 1098 } } ], "endShape" : { "a" : { "x" : 1540, "y" : 1097 }, "b" : { "x" : 1548, "y" : 1098 }, "c" : { "x" : 1545, "y" : 1091 }, "type" : "ARROW", "centre" : { "x" : 1545, "y" : 1091 } }, "reactionShape" : { "c" : { "x" : 1523, "y" : 1080 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1523, "y" : 1080 } }, "inputs" : [ { "id" : 132949, "points" : [ { "x" : 1480, "y" : 1099 } ] }, { "id" : 132943, "points" : [ { "x" : 1228, "y" : 1027 } ] } ], "outputs" : [ { "id" : 132950 } ] }, { "id" : 133210, "reactomeId" : 10431986, "displayName" : "β-blockers bind ADRB1,2,3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 4122, "y" : 1386 }, "minX" : 4083, "maxX" : 4167, "minY" : 1370, "maxY" : 1409, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 4161, "y" : 1403 }, "to" : { "x" : 4122, "y" : 1386 } }, { "from" : { "x" : 4122, "y" : 1386 }, "to" : { "x" : 4083, "y" : 1370 } } ], "endShape" : { "a" : { "x" : 4091, "y" : 1369 }, "b" : { "x" : 4083, "y" : 1370 }, "c" : { "x" : 4088, "y" : 1376 }, "type" : "ARROW", "centre" : { "x" : 4088, "y" : 1376 } }, "reactionShape" : { "c" : { "x" : 4122, "y" : 1386 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 4122, "y" : 1386 } }, "inputs" : [ { "id" : 133211, "points" : [ { "x" : 4233, "y" : 1403 } ] }, { "id" : 133212, "points" : [ { "x" : 4062, "y" : 1403 } ] } ], "outputs" : [ { "id" : 132925 } ] }, { "id" : 132698, "reactomeId" : 10357112, "displayName" : "Bombesin-like receptors bind bombesin homologues", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 879, "y" : 53 }, "minX" : 859, "maxX" : 900, "minY" : 47, "maxY" : 61, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 859, "y" : 54 }, "to" : { "x" : 879, "y" : 53 } }, { "from" : { "x" : 879, "y" : 53 }, "to" : { "x" : 900, "y" : 61 } } ], "endShape" : { "a" : { "x" : 892, "y" : 62 }, "b" : { "x" : 900, "y" : 61 }, "c" : { "x" : 895, "y" : 55 }, "type" : "ARROW", "centre" : { "x" : 895, "y" : 55 } }, "reactionShape" : { "c" : { "x" : 879, "y" : 53 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 879, "y" : 53 } }, "inputs" : [ { "id" : 132699, "points" : [ { "x" : 845, "y" : 62 } ] }, { "id" : 132700, "points" : [ { "x" : 836, "y" : 50 } ] } ], "outputs" : [ { "id" : 132701 } ] }, { "id" : 132955, "reactomeId" : 10361057, "displayName" : "Follicle-stimulating hormone receptor can bind FSH", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1775, "y" : 1090 }, "minX" : 1758, "maxX" : 1782, "minY" : 1084, "maxY" : 1103, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1758, "y" : 1090 }, "to" : { "x" : 1775, "y" : 1090 } }, { "from" : { "x" : 1775, "y" : 1090 }, "to" : { "x" : 1782, "y" : 1103 } } ], "endShape" : { "a" : { "x" : 1775, "y" : 1099 }, "b" : { "x" : 1782, "y" : 1103 }, "c" : { "x" : 1782, "y" : 1095 }, "type" : "ARROW", "centre" : { "x" : 1782, "y" : 1095 } }, "reactionShape" : { "c" : { "x" : 1775, "y" : 1090 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1775, "y" : 1090 } }, "inputs" : [ { "id" : 132956, "points" : [ { "x" : 1737, "y" : 1083 } ] }, { "id" : 132957, "points" : [ { "x" : 1738, "y" : 1102 } ] } ], "outputs" : [ { "id" : 132958 } ] }, { "id" : 132702, "reactomeId" : 10356814, "displayName" : "Bradykinin receptors B1 and B2 bind to bradykinin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1168, "y" : 54 }, "minX" : 1144, "maxX" : 1194, "minY" : 48, "maxY" : 66, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1144, "y" : 55 }, "to" : { "x" : 1168, "y" : 54 } }, { "from" : { "x" : 1168, "y" : 54 }, "to" : { "x" : 1194, "y" : 66 } } ], "endShape" : { "a" : { "x" : 1186, "y" : 67 }, "b" : { "x" : 1194, "y" : 66 }, "c" : { "x" : 1189, "y" : 59 }, "type" : "ARROW", "centre" : { "x" : 1189, "y" : 59 } }, "reactionShape" : { "c" : { "x" : 1168, "y" : 54 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1168, "y" : 54 } }, "inputs" : [ { "id" : 132703, "points" : [ { "x" : 1107, "y" : 42 } ] }, { "id" : 132704, "points" : [ { "x" : 1129, "y" : 55 } ] } ], "outputs" : [ { "id" : 132705 } ] }, { "id" : 133215, "reactomeId" : 10432163, "displayName" : "AGT(25-32) binds to AGTR2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 639, "y" : 45 }, "minX" : 629, "maxX" : 645, "minY" : 39, "maxY" : 62, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 639, "y" : 44 }, "to" : { "x" : 639, "y" : 45 } }, { "from" : { "x" : 639, "y" : 45 }, "to" : { "x" : 629, "y" : 62 } } ], "endShape" : { "a" : { "x" : 629, "y" : 54 }, "b" : { "x" : 629, "y" : 62 }, "c" : { "x" : 636, "y" : 58 }, "type" : "ARROW", "centre" : { "x" : 636, "y" : 58 } }, "reactionShape" : { "c" : { "x" : 639, "y" : 45 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 639, "y" : 45 } }, "inputs" : [ { "id" : 133216, "points" : [ { "x" : 689, "y" : 72 } ] }, { "id" : 132690, "points" : [ { "x" : 589, "y" : 36 } ] } ], "outputs" : [ { "id" : 133217 } ] }, { "id" : 132959, "reactomeId" : 10361050, "displayName" : "GNRHR binds GNRH1,2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1871, "y" : 2731 }, "minX" : 1865, "maxX" : 1895, "minY" : 2718, "maxY" : 2737, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1872, "y" : 2731 }, "to" : { "x" : 1871, "y" : 2731 } }, { "from" : { "x" : 1871, "y" : 2731 }, "to" : { "x" : 1895, "y" : 2718 } } ], "endShape" : { "a" : { "x" : 1891, "y" : 2725 }, "b" : { "x" : 1895, "y" : 2718 }, "c" : { "x" : 1887, "y" : 2718 }, "type" : "ARROW", "centre" : { "x" : 1887, "y" : 2718 } }, "reactionShape" : { "c" : { "x" : 1871, "y" : 2731 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1871, "y" : 2731 } }, "inputs" : [ { "id" : 132960, "points" : [ { "x" : 1873, "y" : 2748 } ] }, { "id" : 132961, "points" : [ { "x" : 1842, "y" : 2717 } ] } ], "outputs" : [ { "id" : 132962 } ] }, { "id" : 133213, "reactomeId" : 10432161, "displayName" : "ARBs bind AGTR1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 343, "y" : 52 }, "minX" : 321, "maxX" : 349, "minY" : 46, "maxY" : 70, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 343, "y" : 52 }, "to" : { "x" : 346, "y" : 53 } }, { "from" : { "x" : 346, "y" : 53 }, "to" : { "x" : 321, "y" : 70 } } ], "endShape" : { "a" : { "x" : 324, "y" : 63 }, "b" : { "x" : 321, "y" : 70 }, "c" : { "x" : 329, "y" : 69 }, "type" : "ARROW", "centre" : { "x" : 329, "y" : 69 } }, "reactionShape" : { "c" : { "x" : 343, "y" : 52 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 343, "y" : 52 } }, "inputs" : [ { "id" : 132691, "points" : [ { "x" : 374, "y" : 69 } ] }, { "id" : 133214, "points" : [ { "x" : 319, "y" : 48 } ] } ], "outputs" : [ { "id" : 132693 } ] }, { "id" : 132706, "reactomeId" : 10357120, "displayName" : "C5a receptor binds C5a anaphylatoxin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1581, "y" : 56 }, "minX" : 1559, "maxX" : 1596, "minY" : 50, "maxY" : 62, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1559, "y" : 56 }, "to" : { "x" : 1581, "y" : 56 } }, { "from" : { "x" : 1581, "y" : 56 }, "to" : { "x" : 1596, "y" : 61 } } ], "endShape" : { "a" : { "x" : 1588, "y" : 63 }, "b" : { "x" : 1596, "y" : 61 }, "c" : { "x" : 1591, "y" : 55 }, "type" : "ARROW", "centre" : { "x" : 1591, "y" : 55 } }, "reactionShape" : { "c" : { "x" : 1581, "y" : 56 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1581, "y" : 56 } }, "inputs" : [ { "id" : 132707, "points" : [ { "x" : 1539, "y" : 47 } ] }, { "id" : 132708, "points" : [ { "x" : 1543, "y" : 66 } ] } ], "outputs" : [ { "id" : 132709 } ] }, { "id" : 133218, "reactomeId" : 10432072, "displayName" : "β1,2-agonists bind ADRB1,2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 4073, "y" : 1496 }, "minX" : 4050, "maxX" : 4103, "minY" : 1476, "maxY" : 1523, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 4097, "y" : 1517 }, "to" : { "x" : 4073, "y" : 1496 } }, { "from" : { "x" : 4073, "y" : 1496 }, "to" : { "x" : 4050, "y" : 1476 } } ], "endShape" : { "a" : { "x" : 4058, "y" : 1478 }, "b" : { "x" : 4050, "y" : 1476 }, "c" : { "x" : 4053, "y" : 1484 }, "type" : "ARROW", "centre" : { "x" : 4053, "y" : 1484 } }, "reactionShape" : { "c" : { "x" : 4073, "y" : 1496 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 4073, "y" : 1496 } }, "inputs" : [ { "id" : 133219, "points" : [ { "x" : 4079, "y" : 1516 } ] }, { "id" : 133220, "points" : [ { "x" : 4237, "y" : 1517 } ] } ], "outputs" : [ { "id" : 132923 } ] }, { "id" : 132963, "reactomeId" : 10361055, "displayName" : "Luteinizing hormone receptor can bind LH", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3537, "y" : 1100 }, "minX" : 3513, "maxX" : 3557, "minY" : 1094, "maxY" : 1108, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3513, "y" : 1099 }, "to" : { "x" : 3537, "y" : 1100 } }, { "from" : { "x" : 3537, "y" : 1100 }, "to" : { "x" : 3557, "y" : 1108 } } ], "endShape" : { "a" : { "x" : 3549, "y" : 1109 }, "b" : { "x" : 3557, "y" : 1108 }, "c" : { "x" : 3552, "y" : 1102 }, "type" : "ARROW", "centre" : { "x" : 3552, "y" : 1102 } }, "reactionShape" : { "c" : { "x" : 3537, "y" : 1100 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3537, "y" : 1100 } }, "inputs" : [ { "id" : 132964, "points" : [ { "x" : 3486, "y" : 1088 } ] }, { "id" : 132965, "points" : [ { "x" : 3491, "y" : 1106 } ] } ], "outputs" : [ { "id" : 132966 } ] }, { "id" : 132710, "reactomeId" : 10365185, "displayName" : "C3a receptor binds anaphylatoxin C3a", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1770, "y" : 50 }, "minX" : 1748, "maxX" : 1793, "minY" : 44, "maxY" : 61, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1748, "y" : 50 }, "to" : { "x" : 1770, "y" : 50 } }, { "from" : { "x" : 1770, "y" : 50 }, "to" : { "x" : 1793, "y" : 61 } } ], "endShape" : { "a" : { "x" : 1785, "y" : 62 }, "b" : { "x" : 1793, "y" : 61 }, "c" : { "x" : 1788, "y" : 54 }, "type" : "ARROW", "centre" : { "x" : 1788, "y" : 54 } }, "reactionShape" : { "c" : { "x" : 1770, "y" : 50 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1770, "y" : 50 } }, "inputs" : [ { "id" : 132711, "points" : [ { "x" : 1734, "y" : 45 } ] }, { "id" : 132712, "points" : [ { "x" : 1734, "y" : 65 } ] } ], "outputs" : [ { "id" : 132713 } ] }, { "id" : 132967, "reactomeId" : 10361053, "displayName" : "TSHR binds TSH/Thyrostimulin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3745, "y" : 1104 }, "minX" : 3729, "maxX" : 3766, "minY" : 1098, "maxY" : 1110, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3729, "y" : 1105 }, "to" : { "x" : 3745, "y" : 1104 } }, { "from" : { "x" : 3745, "y" : 1104 }, "to" : { "x" : 3766, "y" : 1110 } } ], "endShape" : { "a" : { "x" : 3758, "y" : 1112 }, "b" : { "x" : 3766, "y" : 1110 }, "c" : { "x" : 3760, "y" : 1104 }, "type" : "ARROW", "centre" : { "x" : 3760, "y" : 1104 } }, "reactionShape" : { "a" : { "x" : 3739, "y" : 1098 }, "b" : { "x" : 3751, "y" : 1110 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3745, "y" : 1104 } }, "inputs" : [ { "id" : 132968, "points" : [ { "x" : 3710, "y" : 1115 } ] }, { "id" : 132969, "points" : [ { "x" : 3707, "y" : 1095 } ] } ], "outputs" : [ { "id" : 132970 } ], "catalysts" : [ { "id" : 132968, "points" : [ { "x" : 3710, "y" : 1125 }, { "x" : 3735, "y" : 1125 } ] } ] }, { "id" : 133221, "reactomeId" : 10432078, "displayName" : "ADRB2 bind ADR,NAd", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 4182, "y" : 1551 }, "minX" : 4074, "maxX" : 4188, "minY" : 1545, "maxY" : 1563, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 4182, "y" : 1550 }, "to" : { "x" : 4182, "y" : 1551 } }, { "from" : { "x" : 4182, "y" : 1551 }, "to" : { "x" : 4074, "y" : 1563 } } ], "endShape" : { "a" : { "x" : 4080, "y" : 1558 }, "b" : { "x" : 4074, "y" : 1563 }, "c" : { "x" : 4081, "y" : 1566 }, "type" : "ARROW", "centre" : { "x" : 4081, "y" : 1566 } }, "reactionShape" : { "c" : { "x" : 4182, "y" : 1551 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 4182, "y" : 1551 } }, "inputs" : [ { "id" : 133222, "points" : [ { "x" : 4068, "y" : 1598 } ] }, { "id" : 132920, "points" : [ { "x" : 4202, "y" : 1326 } ] } ], "outputs" : [ { "id" : 133223 } ], "inhibitors" : [ { "id" : 132925, "points" : [ { "x" : 4053, "y" : 1376 } ] } ], "activators" : [ { "id" : 132923, "points" : [ { "x" : 4059, "y" : 1476 } ] } ] }, { "id" : 132714, "reactomeId" : 10356766, "displayName" : "DARC is a non-specific receptor for many chemokines", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1389, "y" : 57 }, "minX" : 1369, "maxX" : 1411, "minY" : 51, "maxY" : 70, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1369, "y" : 58 }, "to" : { "x" : 1389, "y" : 57 } }, { "from" : { "x" : 1389, "y" : 57 }, "to" : { "x" : 1411, "y" : 70 } } ], "endShape" : { "a" : { "x" : 1403, "y" : 70 }, "b" : { "x" : 1411, "y" : 70 }, "c" : { "x" : 1407, "y" : 63 }, "type" : "ARROW", "centre" : { "x" : 1407, "y" : 63 } }, "reactionShape" : { "c" : { "x" : 1389, "y" : 57 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1389, "y" : 57 } }, "inputs" : [ { "id" : 132715, "points" : [ { "x" : 1335, "y" : 38 } ] }, { "id" : 132716, "points" : [ { "x" : 1357, "y" : 66 } ] } ], "outputs" : [ { "id" : 132717 } ] }, { "id" : 132971, "reactomeId" : 10361067, "displayName" : "EP1 receptor can bind PGE2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2598, "y" : 1094 }, "minX" : 2577, "maxX" : 2615, "minY" : 1088, "maxY" : 1105, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2577, "y" : 1093 }, "to" : { "x" : 2598, "y" : 1094 } }, { "from" : { "x" : 2598, "y" : 1094 }, "to" : { "x" : 2615, "y" : 1105 } } ], "endShape" : { "a" : { "x" : 2607, "y" : 1105 }, "b" : { "x" : 2615, "y" : 1105 }, "c" : { "x" : 2611, "y" : 1098 }, "type" : "ARROW", "centre" : { "x" : 2611, "y" : 1098 } }, "reactionShape" : { "c" : { "x" : 2598, "y" : 1094 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2598, "y" : 1094 } }, "inputs" : [ { "id" : 132972, "points" : [ { "x" : 2557, "y" : 1074 } ] }, { "id" : 132973, "points" : [ { "x" : 2560, "y" : 1104 } ] } ], "outputs" : [ { "id" : 132974 } ] }, { "id" : 133224, "reactomeId" : 10432080, "displayName" : "ADRB3 bind ADR,NAd", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 4149, "y" : 1152 }, "minX" : 4072, "maxX" : 4155, "minY" : 1146, "maxY" : 1162, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 4149, "y" : 1150 }, "to" : { "x" : 4149, "y" : 1152 } }, { "from" : { "x" : 4149, "y" : 1152 }, "to" : { "x" : 4072, "y" : 1162 } } ], "endShape" : { "a" : { "x" : 4078, "y" : 1157 }, "b" : { "x" : 4072, "y" : 1162 }, "c" : { "x" : 4079, "y" : 1165 }, "type" : "ARROW", "centre" : { "x" : 4079, "y" : 1165 } }, "reactionShape" : { "c" : { "x" : 4149, "y" : 1152 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 4149, "y" : 1152 } }, "inputs" : [ { "id" : 132920, "points" : [ { "x" : 4197, "y" : 1277 } ] }, { "id" : 133225, "points" : [ { "x" : 4066, "y" : 1125 } ] } ], "outputs" : [ { "id" : 133226 } ], "inhibitors" : [ { "id" : 132925, "points" : [ { "x" : 4083, "y" : 1356 }, { "x" : 4148, "y" : 1360 } ] } ], "activators" : [ { "id" : 133227, "points" : [ { "x" : 3979, "y" : 1127 } ] } ] }, { "id" : 132718, "reactomeId" : 10356939, "displayName" : "GPCR neuropeptide receptor binds neuropeptides B and W", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2236, "y" : 43 }, "minX" : 2213, "maxX" : 2259, "minY" : 37, "maxY" : 56, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2213, "y" : 44 }, "to" : { "x" : 2236, "y" : 43 } }, { "from" : { "x" : 2236, "y" : 43 }, "to" : { "x" : 2259, "y" : 56 } } ], "endShape" : { "a" : { "x" : 2251, "y" : 56 }, "b" : { "x" : 2259, "y" : 56 }, "c" : { "x" : 2255, "y" : 49 }, "type" : "ARROW", "centre" : { "x" : 2255, "y" : 49 } }, "reactionShape" : { "c" : { "x" : 2236, "y" : 43 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2236, "y" : 43 } }, "inputs" : [ { "id" : 132719, "points" : [ { "x" : 2192, "y" : 41 } ] }, { "id" : 132720, "points" : [ { "x" : 2193, "y" : 50 } ] } ], "outputs" : [ { "id" : 132721 } ] }, { "id" : 133230, "reactomeId" : 10432070, "displayName" : "β1-agonists bind ADRB1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 4128, "y" : 1220 }, "minX" : 4072, "maxX" : 4134, "minY" : 1214, "maxY" : 1226, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 4130, "y" : 1220 }, "to" : { "x" : 4128, "y" : 1220 } }, { "from" : { "x" : 4128, "y" : 1220 }, "to" : { "x" : 4072, "y" : 1215 } } ], "endShape" : { "a" : { "x" : 4079, "y" : 1212 }, "b" : { "x" : 4072, "y" : 1215 }, "c" : { "x" : 4079, "y" : 1220 }, "type" : "ARROW", "centre" : { "x" : 4079, "y" : 1220 } }, "reactionShape" : { "c" : { "x" : 4128, "y" : 1220 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 4128, "y" : 1220 } }, "inputs" : [ { "id" : 132921, "points" : [ { "x" : 4075, "y" : 1242 } ] }, { "id" : 133231, "points" : [ { "x" : 4225, "y" : 1218 } ] } ], "outputs" : [ { "id" : 132924 } ] }, { "id" : 132975, "reactomeId" : 10361073, "displayName" : "EP2 and EP4 receptors can bind PGE2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2807, "y" : 1092 }, "minX" : 2782, "maxX" : 2826, "minY" : 1086, "maxY" : 1101, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2782, "y" : 1087 }, "to" : { "x" : 2807, "y" : 1092 } }, { "from" : { "x" : 2807, "y" : 1092 }, "to" : { "x" : 2826, "y" : 1101 } } ], "endShape" : { "a" : { "x" : 2818, "y" : 1102 }, "b" : { "x" : 2826, "y" : 1101 }, "c" : { "x" : 2821, "y" : 1094 }, "type" : "ARROW", "centre" : { "x" : 2821, "y" : 1094 } }, "reactionShape" : { "c" : { "x" : 2807, "y" : 1092 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2807, "y" : 1092 } }, "inputs" : [ { "id" : 132972, "points" : [ { "x" : 2588, "y" : 1062 } ] }, { "id" : 132976, "points" : [ { "x" : 2765, "y" : 1097 } ] } ], "outputs" : [ { "id" : 132977 } ] }, { "id" : 133228, "reactomeId" : 10432076, "displayName" : "β3-agonists bind ADRB3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3999, "y" : 1072 }, "minX" : 3958, "maxX" : 4005, "minY" : 1066, "maxY" : 1101, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3998, "y" : 1068 }, "to" : { "x" : 3999, "y" : 1072 } }, { "from" : { "x" : 3999, "y" : 1072 }, "to" : { "x" : 3958, "y" : 1101 } } ], "endShape" : { "a" : { "x" : 3961, "y" : 1094 }, "b" : { "x" : 3958, "y" : 1101 }, "c" : { "x" : 3966, "y" : 1100 }, "type" : "ARROW", "centre" : { "x" : 3966, "y" : 1100 } }, "reactionShape" : { "c" : { "x" : 3999, "y" : 1072 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3999, "y" : 1072 } }, "inputs" : [ { "id" : 133225, "points" : [ { "x" : 4029, "y" : 1104 } ] }, { "id" : 133229, "points" : [ { "x" : 3992, "y" : 1052 } ] } ], "outputs" : [ { "id" : 133227 } ] }, { "id" : 132722, "reactomeId" : 10356877, "displayName" : "Nociceptin receptor binds to nociceptin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2494, "y" : 65 }, "minX" : 2469, "maxX" : 2510, "minY" : 59, "maxY" : 71, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2469, "y" : 65 }, "to" : { "x" : 2494, "y" : 65 } }, { "from" : { "x" : 2494, "y" : 65 }, "to" : { "x" : 2510, "y" : 68 } } ], "endShape" : { "a" : { "x" : 2502, "y" : 71 }, "b" : { "x" : 2510, "y" : 68 }, "c" : { "x" : 2504, "y" : 63 }, "type" : "ARROW", "centre" : { "x" : 2504, "y" : 63 } }, "reactionShape" : { "c" : { "x" : 2494, "y" : 65 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2494, "y" : 65 } }, "inputs" : [ { "id" : 132723, "points" : [ { "x" : 2446, "y" : 57 } ] }, { "id" : 132724, "points" : [ { "x" : 2453, "y" : 72 } ] } ], "outputs" : [ { "id" : 132725 } ] }, { "id" : 133234, "reactomeId" : 10432187, "displayName" : "α1-antagonists bind ADRA1A,B,D", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1858, "y" : 965 }, "minX" : 1852, "maxX" : 1864, "minY" : 933, "maxY" : 971, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1858, "y" : 964 }, "to" : { "x" : 1858, "y" : 965 } }, { "from" : { "x" : 1858, "y" : 965 }, "to" : { "x" : 1858, "y" : 933 } } ], "endShape" : { "a" : { "x" : 1862, "y" : 940 }, "b" : { "x" : 1858, "y" : 933 }, "c" : { "x" : 1854, "y" : 940 }, "type" : "ARROW", "centre" : { "x" : 1854, "y" : 940 } }, "reactionShape" : { "c" : { "x" : 1858, "y" : 965 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1858, "y" : 965 } }, "inputs" : [ { "id" : 133235, "points" : [ { "x" : 1858, "y" : 999 } ] }, { "id" : 132911, "points" : [ { "x" : 1940, "y" : 929 } ] } ], "outputs" : [ { "id" : 132915 } ] }, { "id" : 132978, "reactomeId" : 10361061, "displayName" : "EP3 receptor can bind PGE2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3011, "y" : 1074 }, "minX" : 2968, "maxX" : 3035, "minY" : 1068, "maxY" : 1099, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2968, "y" : 1073 }, "to" : { "x" : 3011, "y" : 1074 } }, { "from" : { "x" : 3011, "y" : 1074 }, "to" : { "x" : 3035, "y" : 1099 } } ], "endShape" : { "a" : { "x" : 3027, "y" : 1097 }, "b" : { "x" : 3035, "y" : 1099 }, "c" : { "x" : 3033, "y" : 1091 }, "type" : "ARROW", "centre" : { "x" : 3033, "y" : 1091 } }, "reactionShape" : { "c" : { "x" : 3011, "y" : 1074 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3011, "y" : 1074 } }, "inputs" : [ { "id" : 132979, "points" : [ { "x" : 2963, "y" : 1102 } ] }, { "id" : 132972, "points" : [ { "x" : 2588, "y" : 1058 } ] } ], "outputs" : [ { "id" : 132980 } ] }, { "id" : 133232, "reactomeId" : 10432068, "displayName" : "P2RY12 binds P2RY12 antagonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1007, "y" : 1669 }, "minX" : 1001, "maxX" : 1013, "minY" : 1634, "maxY" : 1675, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1007, "y" : 1668 }, "to" : { "x" : 1007, "y" : 1669 } }, { "from" : { "x" : 1007, "y" : 1669 }, "to" : { "x" : 1007, "y" : 1634 } } ], "endShape" : { "a" : { "x" : 1011, "y" : 1641 }, "b" : { "x" : 1007, "y" : 1634 }, "c" : { "x" : 1003, "y" : 1641 }, "type" : "ARROW", "centre" : { "x" : 1003, "y" : 1641 } }, "reactionShape" : { "c" : { "x" : 1007, "y" : 1669 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1007, "y" : 1669 } }, "inputs" : [ { "id" : 133233, "points" : [ { "x" : 972, "y" : 1668 } ] }, { "id" : 133025, "points" : [ { "x" : 1089, "y" : 1623 } ] } ], "outputs" : [ { "id" : 133027 } ] }, { "id" : 133238, "reactomeId" : 10432426, "displayName" : "α2-agonists bind ADRA2A,B,C", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2582, "y" : 1010 }, "minX" : 2576, "maxX" : 2615, "minY" : 938, "maxY" : 1016, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2583, "y" : 1010 }, "to" : { "x" : 2582, "y" : 1010 } }, { "from" : { "x" : 2582, "y" : 1010 }, "to" : { "x" : 2615, "y" : 938 } } ], "endShape" : { "a" : { "x" : 2616, "y" : 946 }, "b" : { "x" : 2615, "y" : 938 }, "c" : { "x" : 2608, "y" : 943 }, "type" : "ARROW", "centre" : { "x" : 2608, "y" : 943 } }, "reactionShape" : { "c" : { "x" : 2582, "y" : 1010 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2582, "y" : 1010 } }, "inputs" : [ { "id" : 132917, "points" : [ { "x" : 2388, "y" : 935 } ] }, { "id" : 133239, "points" : [ { "x" : 2645, "y" : 1010 } ] } ], "outputs" : [ { "id" : 133240 } ] }, { "id" : 132726, "reactomeId" : 10356804, "displayName" : "Opioid receptors bind opioid peptides", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2754, "y" : 51 }, "minX" : 2729, "maxX" : 2783, "minY" : 45, "maxY" : 60, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2729, "y" : 50 }, "to" : { "x" : 2754, "y" : 51 } }, { "from" : { "x" : 2754, "y" : 51 }, "to" : { "x" : 2783, "y" : 60 } } ], "endShape" : { "a" : { "x" : 2775, "y" : 62 }, "b" : { "x" : 2783, "y" : 60 }, "c" : { "x" : 2778, "y" : 54 }, "type" : "ARROW", "centre" : { "x" : 2778, "y" : 54 } }, "reactionShape" : { "c" : { "x" : 2754, "y" : 51 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2754, "y" : 51 } }, "inputs" : [ { "id" : 132727, "points" : [ { "x" : 2714, "y" : 41 } ] }, { "id" : 132728, "points" : [ { "x" : 2718, "y" : 60 } ] } ], "outputs" : [ { "id" : 132729 } ] }, { "id" : 133236, "reactomeId" : 10432322, "displayName" : "α1-agonists bind ADRA1A,B,D", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2015, "y" : 937 }, "minX" : 1965, "maxX" : 2060, "minY" : 924, "maxY" : 956, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1971, "y" : 950 }, "to" : { "x" : 2015, "y" : 937 } }, { "from" : { "x" : 2015, "y" : 937 }, "to" : { "x" : 2060, "y" : 924 } } ], "endShape" : { "a" : { "x" : 2054, "y" : 930 }, "b" : { "x" : 2060, "y" : 924 }, "c" : { "x" : 2052, "y" : 922 }, "type" : "ARROW", "centre" : { "x" : 2052, "y" : 922 } }, "reactionShape" : { "c" : { "x" : 2015, "y" : 937 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2015, "y" : 937 } }, "inputs" : [ { "id" : 133237, "points" : [ { "x" : 1971, "y" : 997 } ] }, { "id" : 132911, "points" : [ { "x" : 1971, "y" : 929 } ] } ], "outputs" : [ { "id" : 132914 } ] }, { "id" : 132981, "reactomeId" : 10361881, "displayName" : "PTGFR binds PGF2a", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1683, "y" : 2412 }, "minX" : 1677, "maxX" : 1695, "minY" : 2406, "maxY" : 2458, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1682, "y" : 2411 }, "to" : { "x" : 1683, "y" : 2412 } }, { "from" : { "x" : 1683, "y" : 2412 }, "to" : { "x" : 1695, "y" : 2458 } } ], "endShape" : { "a" : { "x" : 1689, "y" : 2452 }, "b" : { "x" : 1695, "y" : 2458 }, "c" : { "x" : 1697, "y" : 2450 }, "type" : "ARROW", "centre" : { "x" : 1697, "y" : 2450 } }, "reactionShape" : { "c" : { "x" : 1683, "y" : 2412 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1683, "y" : 2412 } }, "inputs" : [ { "id" : 132982, "points" : [ { "x" : 1684, "y" : 2383 } ] }, { "id" : 132983, "points" : [ { "x" : 1643, "y" : 2465 } ] } ], "outputs" : [ { "id" : 132984 } ] }, { "id" : 132730, "reactomeId" : 10356436, "displayName" : "Receptor CCR10 binds CCL27 and 28 ligands", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3920, "y" : 394 }, "minX" : 3901, "maxX" : 3954, "minY" : 381, "maxY" : 400, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3901, "y" : 395 }, "to" : { "x" : 3920, "y" : 394 } }, { "from" : { "x" : 3920, "y" : 394 }, "to" : { "x" : 3954, "y" : 381 } } ], "endShape" : { "a" : { "x" : 3949, "y" : 387 }, "b" : { "x" : 3954, "y" : 381 }, "c" : { "x" : 3946, "y" : 380 }, "type" : "ARROW", "centre" : { "x" : 3946, "y" : 380 } }, "reactionShape" : { "c" : { "x" : 3920, "y" : 394 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3920, "y" : 394 } }, "inputs" : [ { "id" : 132731, "points" : [ { "x" : 3875, "y" : 410 } ] }, { "id" : 132732, "points" : [ { "x" : 3873, "y" : 382 } ] } ], "outputs" : [ { "id" : 132733 } ] }, { "id" : 133241, "reactomeId" : 10433444, "displayName" : "DRD2 antagonist drugs bind to DRD2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 148, "y" : 1247 }, "minX" : 142, "maxX" : 154, "minY" : 1241, "maxY" : 1294, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 148, "y" : 1246 }, "to" : { "x" : 148, "y" : 1247 } }, { "from" : { "x" : 148, "y" : 1247 }, "to" : { "x" : 147, "y" : 1294 } } ], "endShape" : { "a" : { "x" : 143, "y" : 1287 }, "b" : { "x" : 147, "y" : 1294 }, "c" : { "x" : 151, "y" : 1287 }, "type" : "ARROW", "centre" : { "x" : 151, "y" : 1287 } }, "reactionShape" : { "c" : { "x" : 148, "y" : 1247 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 148, "y" : 1247 } }, "inputs" : [ { "id" : 133242, "points" : [ { "x" : 132, "y" : 1240 } ] }, { "id" : 133243, "points" : [ { "x" : 148, "y" : 1199 } ] } ], "outputs" : [ { "id" : 133244 } ] }, { "id" : 132985, "reactomeId" : 10361077, "displayName" : "IP receptor can bind prostacyclin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3169, "y" : 1092 }, "minX" : 3147, "maxX" : 3184, "minY" : 1086, "maxY" : 1098, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3147, "y" : 1092 }, "to" : { "x" : 3169, "y" : 1092 } }, { "from" : { "x" : 3169, "y" : 1092 }, "to" : { "x" : 3184, "y" : 1098 } } ], "endShape" : { "a" : { "x" : 3176, "y" : 1099 }, "b" : { "x" : 3184, "y" : 1098 }, "c" : { "x" : 3179, "y" : 1092 }, "type" : "ARROW", "centre" : { "x" : 3179, "y" : 1092 } }, "reactionShape" : { "c" : { "x" : 3169, "y" : 1092 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3169, "y" : 1092 } }, "inputs" : [ { "id" : 132986, "points" : [ { "x" : 3133, "y" : 1083 } ] }, { "id" : 132987, "points" : [ { "x" : 3135, "y" : 1105 } ] } ], "outputs" : [ { "id" : 132988 } ] }, { "id" : 132734, "reactomeId" : 10356448, "displayName" : "Receptor CCR6 binds CCL20 ligand", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1961, "y" : 407 }, "minX" : 1940, "maxX" : 1989, "minY" : 388, "maxY" : 413, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1940, "y" : 408 }, "to" : { "x" : 1961, "y" : 407 } }, { "from" : { "x" : 1961, "y" : 407 }, "to" : { "x" : 1989, "y" : 388 } } ], "endShape" : { "a" : { "x" : 1986, "y" : 395 }, "b" : { "x" : 1989, "y" : 388 }, "c" : { "x" : 1981, "y" : 389 }, "type" : "ARROW", "centre" : { "x" : 1981, "y" : 389 } }, "reactionShape" : { "c" : { "x" : 1961, "y" : 407 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1961, "y" : 407 } }, "inputs" : [ { "id" : 132735, "points" : [ { "x" : 1928, "y" : 417 } ] }, { "id" : 132736, "points" : [ { "x" : 1919, "y" : 390 } ] } ], "outputs" : [ { "id" : 132737 } ] }, { "id" : 133247, "reactomeId" : 10433685, "displayName" : "AVPR1A,B bind desmopressin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 119, "y" : 2478 }, "minX" : 113, "maxX" : 218, "minY" : 2472, "maxY" : 2484, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 118, "y" : 2478 }, "to" : { "x" : 119, "y" : 2478 } }, { "from" : { "x" : 119, "y" : 2478 }, "to" : { "x" : 218, "y" : 2478 } } ], "endShape" : { "a" : { "x" : 211, "y" : 2482 }, "b" : { "x" : 218, "y" : 2478 }, "c" : { "x" : 211, "y" : 2474 }, "type" : "ARROW", "centre" : { "x" : 211, "y" : 2474 } }, "reactionShape" : { "c" : { "x" : 119, "y" : 2478 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 119, "y" : 2478 } }, "inputs" : [ { "id" : 132807, "points" : [ { "x" : 153, "y" : 2497 } ] }, { "id" : 133248, "points" : [ { "x" : 42, "y" : 2599 }, { "x" : 11, "y" : 2500 } ] } ], "outputs" : [ { "id" : 133249 } ] }, { "id" : 133245, "reactomeId" : 10433490, "displayName" : "DRD2 binds DA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 237, "y" : 1117 }, "minX" : 203, "maxX" : 243, "minY" : 1111, "maxY" : 1123, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 235, "y" : 1117 }, "to" : { "x" : 237, "y" : 1117 } }, { "from" : { "x" : 237, "y" : 1117 }, "to" : { "x" : 203, "y" : 1117 } } ], "endShape" : { "a" : { "x" : 210, "y" : 1113 }, "b" : { "x" : 203, "y" : 1117 }, "c" : { "x" : 210, "y" : 1121 }, "type" : "ARROW", "centre" : { "x" : 210, "y" : 1121 } }, "reactionShape" : { "c" : { "x" : 237, "y" : 1117 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 237, "y" : 1117 } }, "inputs" : [ { "id" : 133243, "points" : [ { "x" : 162, "y" : 1171 } ] }, { "id" : 132928, "points" : [ { "x" : 300, "y" : 1054 } ] } ], "outputs" : [ { "id" : 133246 } ] }, { "id" : 132989, "reactomeId" : 10361071, "displayName" : "TP receptor can bind thromboxane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1366, "y" : 1641 }, "minX" : 1349, "maxX" : 1389, "minY" : 1627, "maxY" : 1647, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1349, "y" : 1641 }, "to" : { "x" : 1366, "y" : 1641 } }, { "from" : { "x" : 1366, "y" : 1641 }, "to" : { "x" : 1389, "y" : 1627 } } ], "endShape" : { "a" : { "x" : 1385, "y" : 1634 }, "b" : { "x" : 1389, "y" : 1627 }, "c" : { "x" : 1381, "y" : 1627 }, "type" : "ARROW", "centre" : { "x" : 1381, "y" : 1627 } }, "reactionShape" : { "c" : { "x" : 1366, "y" : 1641 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1366, "y" : 1641 } }, "inputs" : [ { "id" : 132990, "points" : [ { "x" : 1335, "y" : 1658 } ] }, { "id" : 132991, "points" : [ { "x" : 1335, "y" : 1627 } ] } ], "outputs" : [ { "id" : 132992 } ] }, { "id" : 133250, "reactomeId" : 10433689, "displayName" : "AVPR2 bind desmopressin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 65, "y" : 2680 }, "minX" : 59, "maxX" : 124, "minY" : 2664, "maxY" : 2686, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 63, "y" : 2680 }, "to" : { "x" : 65, "y" : 2680 } }, { "from" : { "x" : 65, "y" : 2680 }, "to" : { "x" : 124, "y" : 2664 } } ], "endShape" : { "a" : { "x" : 118, "y" : 2670 }, "b" : { "x" : 124, "y" : 2664 }, "c" : { "x" : 116, "y" : 2662 }, "type" : "ARROW", "centre" : { "x" : 116, "y" : 2662 } }, "reactionShape" : { "c" : { "x" : 65, "y" : 2680 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 65, "y" : 2680 } }, "inputs" : [ { "id" : 133248, "points" : [ { "x" : 49, "y" : 2631 } ] }, { "id" : 132812, "points" : [ { "x" : 184, "y" : 2696 } ] } ], "outputs" : [ { "id" : 133251 } ] }, { "id" : 132738, "reactomeId" : 10356342, "displayName" : "Receptor CCR7 binds CCL19 and 21 ligands", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3165, "y" : 395 }, "minX" : 3147, "maxX" : 3189, "minY" : 382, "maxY" : 401, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3147, "y" : 395 }, "to" : { "x" : 3165, "y" : 395 } }, { "from" : { "x" : 3165, "y" : 395 }, "to" : { "x" : 3189, "y" : 382 } } ], "endShape" : { "a" : { "x" : 3185, "y" : 389 }, "b" : { "x" : 3189, "y" : 382 }, "c" : { "x" : 3181, "y" : 382 }, "type" : "ARROW", "centre" : { "x" : 3181, "y" : 382 } }, "reactionShape" : { "c" : { "x" : 3165, "y" : 395 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3165, "y" : 395 } }, "inputs" : [ { "id" : 132739, "points" : [ { "x" : 3131, "y" : 410 } ] }, { "id" : 132740, "points" : [ { "x" : 3131, "y" : 381 } ] } ], "outputs" : [ { "id" : 132741 } ] }, { "id" : 132993, "reactomeId" : 10361065, "displayName" : "DP1 receptor can bind PGD2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 273, "y" : 1633 }, "minX" : 254, "maxX" : 293, "minY" : 1623, "maxY" : 1639, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 254, "y" : 1633 }, "to" : { "x" : 273, "y" : 1633 } }, { "from" : { "x" : 273, "y" : 1633 }, "to" : { "x" : 293, "y" : 1623 } } ], "endShape" : { "a" : { "x" : 289, "y" : 1630 }, "b" : { "x" : 293, "y" : 1623 }, "c" : { "x" : 285, "y" : 1623 }, "type" : "ARROW", "centre" : { "x" : 285, "y" : 1623 } }, "reactionShape" : { "c" : { "x" : 273, "y" : 1633 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 273, "y" : 1633 } }, "inputs" : [ { "id" : 132994, "points" : [ { "x" : 230, "y" : 1644 } ] }, { "id" : 132995, "points" : [ { "x" : 239, "y" : 1625 } ] } ], "outputs" : [ { "id" : 132996 } ] }, { "id" : 132742, "reactomeId" : 10356376, "displayName" : "Receptor CCR9 binds CCL25 ligand", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3327, "y" : 394 }, "minX" : 3302, "maxX" : 3343, "minY" : 384, "maxY" : 400, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3302, "y" : 395 }, "to" : { "x" : 3327, "y" : 394 } }, { "from" : { "x" : 3327, "y" : 394 }, "to" : { "x" : 3343, "y" : 384 } } ], "endShape" : { "a" : { "x" : 3339, "y" : 391 }, "b" : { "x" : 3343, "y" : 384 }, "c" : { "x" : 3335, "y" : 384 }, "type" : "ARROW", "centre" : { "x" : 3335, "y" : 384 } }, "reactionShape" : { "c" : { "x" : 3327, "y" : 394 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3327, "y" : 394 } }, "inputs" : [ { "id" : 132743, "points" : [ { "x" : 3291, "y" : 379 } ] }, { "id" : 132744, "points" : [ { "x" : 3293, "y" : 406 } ] } ], "outputs" : [ { "id" : 132745 } ] }, { "id" : 133252, "reactomeId" : 10433695, "displayName" : "AVPR1A,2 bind AVPR antagonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 448, "y" : 2480 }, "minX" : 442, "maxX" : 482, "minY" : 2474, "maxY" : 2486, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 447, "y" : 2479 }, "to" : { "x" : 448, "y" : 2480 } }, { "from" : { "x" : 448, "y" : 2480 }, "to" : { "x" : 482, "y" : 2480 } } ], "endShape" : { "a" : { "x" : 475, "y" : 2484 }, "b" : { "x" : 482, "y" : 2480 }, "c" : { "x" : 475, "y" : 2476 }, "type" : "ARROW", "centre" : { "x" : 475, "y" : 2476 } }, "reactionShape" : { "c" : { "x" : 448, "y" : 2480 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 448, "y" : 2480 } }, "inputs" : [ { "id" : 133253, "points" : [ { "x" : 419, "y" : 2420 } ] }, { "id" : 133254, "points" : [ { "x" : 418, "y" : 2479 } ] } ], "outputs" : [ { "id" : 133255 } ] }, { "id" : 132997, "reactomeId" : 10361063, "displayName" : "DP2 receptor can bind PGD2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 464, "y" : 1653 }, "minX" : 430, "maxX" : 489, "minY" : 1637, "maxY" : 1659, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 430, "y" : 1654 }, "to" : { "x" : 464, "y" : 1653 } }, { "from" : { "x" : 464, "y" : 1653 }, "to" : { "x" : 489, "y" : 1637 } } ], "endShape" : { "a" : { "x" : 485, "y" : 1644 }, "b" : { "x" : 489, "y" : 1637 }, "c" : { "x" : 481, "y" : 1637 }, "type" : "ARROW", "centre" : { "x" : 481, "y" : 1637 } }, "reactionShape" : { "c" : { "x" : 464, "y" : 1653 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 464, "y" : 1653 } }, "inputs" : [ { "id" : 132994, "points" : [ { "x" : 237, "y" : 1659 } ] }, { "id" : 132998, "points" : [ { "x" : 419, "y" : 1634 } ] } ], "outputs" : [ { "id" : 132999 } ] }, { "id" : 132746, "reactomeId" : 10356480, "displayName" : "CX3CR1 binds CX3CL1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3551, "y" : 62 }, "minX" : 3526, "maxX" : 3569, "minY" : 56, "maxY" : 71, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3526, "y" : 63 }, "to" : { "x" : 3551, "y" : 62 } }, { "from" : { "x" : 3551, "y" : 62 }, "to" : { "x" : 3569, "y" : 71 } } ], "endShape" : { "a" : { "x" : 3561, "y" : 71 }, "b" : { "x" : 3569, "y" : 71 }, "c" : { "x" : 3565, "y" : 64 }, "type" : "ARROW", "centre" : { "x" : 3565, "y" : 64 } }, "reactionShape" : { "c" : { "x" : 3551, "y" : 62 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3551, "y" : 62 } }, "inputs" : [ { "id" : 132747, "points" : [ { "x" : 3511, "y" : 69 } ] }, { "id" : 132748, "points" : [ { "x" : 3512, "y" : 55 } ] } ], "outputs" : [ { "id" : 132749 } ] }, { "id" : 133256, "reactomeId" : 10433701, "displayName" : "AVPR1A,B,2 bind atosiban", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 705, "y" : 2452 }, "minX" : 687, "maxX" : 730, "minY" : 2439, "maxY" : 2459, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 724, "y" : 2445 }, "to" : { "x" : 705, "y" : 2452 } }, { "from" : { "x" : 705, "y" : 2452 }, "to" : { "x" : 687, "y" : 2459 } } ], "endShape" : { "a" : { "x" : 692, "y" : 2453 }, "b" : { "x" : 687, "y" : 2459 }, "c" : { "x" : 695, "y" : 2460 }, "type" : "ARROW", "centre" : { "x" : 695, "y" : 2460 } }, "reactionShape" : { "c" : { "x" : 705, "y" : 2452 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 705, "y" : 2452 } }, "inputs" : [ { "id" : 133257, "points" : [ { "x" : 758, "y" : 2466 } ] }, { "id" : 133258, "points" : [ { "x" : 702, "y" : 2419 } ] } ], "outputs" : [ { "id" : 133259 } ] }, { "id" : 133000, "reactomeId" : 10361075, "displayName" : "BLT receptors can bind LTB4", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1601, "y" : 1633 }, "minX" : 1585, "maxX" : 1625, "minY" : 1624, "maxY" : 1639, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1585, "y" : 1633 }, "to" : { "x" : 1601, "y" : 1633 } }, { "from" : { "x" : 1601, "y" : 1633 }, "to" : { "x" : 1625, "y" : 1624 } } ], "endShape" : { "a" : { "x" : 1620, "y" : 1630 }, "b" : { "x" : 1625, "y" : 1624 }, "c" : { "x" : 1617, "y" : 1623 }, "type" : "ARROW", "centre" : { "x" : 1617, "y" : 1623 } }, "reactionShape" : { "c" : { "x" : 1601, "y" : 1633 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1601, "y" : 1633 } }, "inputs" : [ { "id" : 133001, "points" : [ { "x" : 1551, "y" : 1650 } ] }, { "id" : 133002, "points" : [ { "x" : 1558, "y" : 1623 } ] } ], "outputs" : [ { "id" : 133003 } ] }, { "id" : 132750, "reactomeId" : 10356468, "displayName" : "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 819, "y" : 391 }, "minX" : 799, "maxX" : 841, "minY" : 383, "maxY" : 397, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 799, "y" : 392 }, "to" : { "x" : 819, "y" : 391 } }, { "from" : { "x" : 819, "y" : 391 }, "to" : { "x" : 841, "y" : 383 } } ], "endShape" : { "a" : { "x" : 836, "y" : 389 }, "b" : { "x" : 841, "y" : 383 }, "c" : { "x" : 833, "y" : 382 }, "type" : "ARROW", "centre" : { "x" : 833, "y" : 382 } }, "reactionShape" : { "c" : { "x" : 819, "y" : 391 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 819, "y" : 391 } }, "inputs" : [ { "id" : 132751, "points" : [ { "x" : 778, "y" : 384 } ] }, { "id" : 132752, "points" : [ { "x" : 772, "y" : 403 } ] } ], "outputs" : [ { "id" : 132753 } ] }, { "id" : 133004, "reactomeId" : 10361079, "displayName" : "CYSLT2 binds LTC4,LTD4,LTE4", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 925, "y" : 2481 }, "minX" : 919, "maxX" : 965, "minY" : 2475, "maxY" : 2487, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 925, "y" : 2480 }, "to" : { "x" : 925, "y" : 2481 } }, { "from" : { "x" : 925, "y" : 2481 }, "to" : { "x" : 965, "y" : 2481 } } ], "endShape" : { "a" : { "x" : 958, "y" : 2485 }, "b" : { "x" : 965, "y" : 2481 }, "c" : { "x" : 958, "y" : 2477 }, "type" : "ARROW", "centre" : { "x" : 958, "y" : 2477 } }, "reactionShape" : { "c" : { "x" : 925, "y" : 2481 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 925, "y" : 2481 } }, "inputs" : [ { "id" : 133005, "points" : [ { "x" : 902, "y" : 2480 } ] }, { "id" : 133006, "points" : [ { "x" : 1030, "y" : 2395 } ] } ], "outputs" : [ { "id" : 133007 } ] }, { "id" : 133260, "reactomeId" : 10434132, "displayName" : "CYSLTR1 binds LTC4,LTD4,LTE4", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1203, "y" : 2480 }, "minX" : 1180, "maxX" : 1232, "minY" : 2474, "maxY" : 2486, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1226, "y" : 2480 }, "to" : { "x" : 1203, "y" : 2480 } }, { "from" : { "x" : 1203, "y" : 2480 }, "to" : { "x" : 1180, "y" : 2480 } } ], "endShape" : { "a" : { "x" : 1187, "y" : 2476 }, "b" : { "x" : 1180, "y" : 2480 }, "c" : { "x" : 1187, "y" : 2484 }, "type" : "ARROW", "centre" : { "x" : 1187, "y" : 2484 } }, "reactionShape" : { "c" : { "x" : 1203, "y" : 2480 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1203, "y" : 2480 } }, "inputs" : [ { "id" : 133261, "points" : [ { "x" : 1263, "y" : 2480 } ] }, { "id" : 133006, "points" : [ { "x" : 1076, "y" : 2395 } ] } ], "outputs" : [ { "id" : 133262 } ], "inhibitors" : [ { "id" : 133263, "points" : [ { "x" : 1343, "y" : 2493 }, { "x" : 1226, "y" : 2520 } ] } ] }, { "id" : 132754, "reactomeId" : 10356683, "displayName" : "Receptor CXCR1 binds CXCL6 and CXCL8 ligands", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1097, "y" : 401 }, "minX" : 1072, "maxX" : 1126, "minY" : 389, "maxY" : 407, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1072, "y" : 401 }, "to" : { "x" : 1097, "y" : 401 } }, { "from" : { "x" : 1097, "y" : 401 }, "to" : { "x" : 1126, "y" : 389 } } ], "endShape" : { "a" : { "x" : 1121, "y" : 395 }, "b" : { "x" : 1126, "y" : 389 }, "c" : { "x" : 1118, "y" : 388 }, "type" : "ARROW", "centre" : { "x" : 1118, "y" : 388 } }, "reactionShape" : { "c" : { "x" : 1097, "y" : 401 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1097, "y" : 401 } }, "inputs" : [ { "id" : 132755, "points" : [ { "x" : 1045, "y" : 384 } ] }, { "id" : 132756, "points" : [ { "x" : 1059, "y" : 409 } ] } ], "outputs" : [ { "id" : 132757 } ] }, { "id" : 133266, "reactomeId" : 10434137, "displayName" : "S1PR1 bind S1P", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2947, "y" : 2731 }, "minX" : 2927, "maxX" : 2974, "minY" : 2714, "maxY" : 2755, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2968, "y" : 2749 }, "to" : { "x" : 2947, "y" : 2731 } }, { "from" : { "x" : 2947, "y" : 2731 }, "to" : { "x" : 2927, "y" : 2714 } } ], "endShape" : { "a" : { "x" : 2935, "y" : 2715 }, "b" : { "x" : 2927, "y" : 2714 }, "c" : { "x" : 2930, "y" : 2722 }, "type" : "ARROW", "centre" : { "x" : 2930, "y" : 2722 } }, "reactionShape" : { "c" : { "x" : 2947, "y" : 2731 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2947, "y" : 2731 } }, "inputs" : [ { "id" : 133267, "points" : [ { "x" : 3003, "y" : 2717 } ] }, { "id" : 133268, "points" : [ { "x" : 2968, "y" : 2780 } ] } ], "outputs" : [ { "id" : 133269 } ], "activators" : [ { "id" : 133270, "points" : [ { "x" : 3048, "y" : 2688 }, { "x" : 2983, "y" : 2665 } ] } ] }, { "id" : 133008, "reactomeId" : 10361069, "displayName" : "UDP/CysLT receptor can bind cysteinyl leukotrienes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3295, "y" : 1662 }, "minX" : 3243, "maxX" : 3301, "minY" : 1643, "maxY" : 1668, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3243, "y" : 1662 }, "to" : { "x" : 3295, "y" : 1662 } }, { "from" : { "x" : 3295, "y" : 1662 }, "to" : { "x" : 3301, "y" : 1643 } } ], "endShape" : { "a" : { "x" : 3303, "y" : 1651 }, "b" : { "x" : 3301, "y" : 1643 }, "c" : { "x" : 3295, "y" : 1648 }, "type" : "ARROW", "centre" : { "x" : 3295, "y" : 1648 } }, "reactionShape" : { "c" : { "x" : 3295, "y" : 1662 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3295, "y" : 1662 } }, "inputs" : [ { "id" : 133009, "points" : [ { "x" : 3226, "y" : 1633 } ] }, { "id" : 133010, "points" : [ { "x" : 3223, "y" : 1696 } ] } ], "outputs" : [ { "id" : 133011 } ] }, { "id" : 133264, "reactomeId" : 10434017, "displayName" : "CYSLTR1 binds CYSLTR1 antagonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1368, "y" : 2439 }, "minX" : 1362, "maxX" : 1388, "minY" : 2433, "maxY" : 2459, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1366, "y" : 2438 }, "to" : { "x" : 1368, "y" : 2439 } }, { "from" : { "x" : 1368, "y" : 2439 }, "to" : { "x" : 1388, "y" : 2459 } } ], "endShape" : { "a" : { "x" : 1380, "y" : 2457 }, "b" : { "x" : 1388, "y" : 2459 }, "c" : { "x" : 1386, "y" : 2451 }, "type" : "ARROW", "centre" : { "x" : 1386, "y" : 2451 } }, "reactionShape" : { "c" : { "x" : 1368, "y" : 2439 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1368, "y" : 2439 } }, "inputs" : [ { "id" : 133265, "points" : [ { "x" : 1366, "y" : 2389 } ] }, { "id" : 133261, "points" : [ { "x" : 1313, "y" : 2467 } ] } ], "outputs" : [ { "id" : 133263 } ] }, { "id" : 132758, "reactomeId" : 10356711, "displayName" : "Receptor CXCR2 binds ligands CXCL1 to 7", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1334, "y" : 405 }, "minX" : 1314, "maxX" : 1360, "minY" : 389, "maxY" : 411, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1314, "y" : 405 }, "to" : { "x" : 1334, "y" : 405 } }, { "from" : { "x" : 1334, "y" : 405 }, "to" : { "x" : 1360, "y" : 389 } } ], "endShape" : { "a" : { "x" : 1356, "y" : 396 }, "b" : { "x" : 1360, "y" : 389 }, "c" : { "x" : 1352, "y" : 389 }, "type" : "ARROW", "centre" : { "x" : 1352, "y" : 389 } }, "reactionShape" : { "c" : { "x" : 1334, "y" : 405 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1334, "y" : 405 } }, "inputs" : [ { "id" : 132759, "points" : [ { "x" : 1288, "y" : 385 } ] }, { "id" : 132760, "points" : [ { "x" : 1288, "y" : 419 } ] } ], "outputs" : [ { "id" : 132761 } ] }, { "id" : 133271, "reactomeId" : 10433956, "displayName" : "S1PR1 binds S1PR1 agonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3095, "y" : 2755 }, "minX" : 3089, "maxX" : 3101, "minY" : 2725, "maxY" : 2761, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3095, "y" : 2756 }, "to" : { "x" : 3095, "y" : 2755 } }, { "from" : { "x" : 3095, "y" : 2755 }, "to" : { "x" : 3095, "y" : 2725 } } ], "endShape" : { "a" : { "x" : 3099, "y" : 2732 }, "b" : { "x" : 3095, "y" : 2725 }, "c" : { "x" : 3091, "y" : 2732 }, "type" : "ARROW", "centre" : { "x" : 3091, "y" : 2732 } }, "reactionShape" : { "c" : { "x" : 3095, "y" : 2755 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3095, "y" : 2755 } }, "inputs" : [ { "id" : 133267, "points" : [ { "x" : 3031, "y" : 2717 } ] }, { "id" : 133272, "points" : [ { "x" : 3095, "y" : 2782 } ] } ], "outputs" : [ { "id" : 133270 } ] }, { "id" : 133012, "reactomeId" : 10361059, "displayName" : "Oxoeicosanoid receptor can bind oxoeicosanoid", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2852, "y" : 1656 }, "minX" : 2834, "maxX" : 2877, "minY" : 1643, "maxY" : 1662, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2834, "y" : 1656 }, "to" : { "x" : 2852, "y" : 1656 } }, { "from" : { "x" : 2852, "y" : 1656 }, "to" : { "x" : 2877, "y" : 1643 } } ], "endShape" : { "a" : { "x" : 2873, "y" : 1650 }, "b" : { "x" : 2877, "y" : 1643 }, "c" : { "x" : 2869, "y" : 1643 }, "type" : "ARROW", "centre" : { "x" : 2869, "y" : 1643 } }, "reactionShape" : { "c" : { "x" : 2852, "y" : 1656 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2852, "y" : 1656 } }, "inputs" : [ { "id" : 133013, "points" : [ { "x" : 2819, "y" : 1662 } ] }, { "id" : 133014, "points" : [ { "x" : 2815, "y" : 1642 } ] } ], "outputs" : [ { "id" : 133015 } ] }, { "id" : 132762, "reactomeId" : 10356758, "displayName" : "Receptor CXCR3 binds ligands CXCL9 to 11", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1545, "y" : 392 }, "minX" : 1524, "maxX" : 1571, "minY" : 383, "maxY" : 398, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1524, "y" : 395 }, "to" : { "x" : 1545, "y" : 392 } }, { "from" : { "x" : 1545, "y" : 392 }, "to" : { "x" : 1571, "y" : 383 } } ], "endShape" : { "a" : { "x" : 1566, "y" : 389 }, "b" : { "x" : 1571, "y" : 383 }, "c" : { "x" : 1563, "y" : 381 }, "type" : "ARROW", "centre" : { "x" : 1563, "y" : 381 } }, "reactionShape" : { "c" : { "x" : 1545, "y" : 392 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1545, "y" : 392 } }, "inputs" : [ { "id" : 132763, "points" : [ { "x" : 1495, "y" : 383 } ] }, { "id" : 132764, "points" : [ { "x" : 1497, "y" : 407 } ] } ], "outputs" : [ { "id" : 132765 } ] }, { "id" : 133016, "reactomeId" : 10361916, "displayName" : "P2RY1 binds ADP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 802, "y" : 1643 }, "minX" : 780, "maxX" : 818, "minY" : 1632, "maxY" : 1661, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 786, "y" : 1655 }, "to" : { "x" : 802, "y" : 1643 } }, { "from" : { "x" : 802, "y" : 1643 }, "to" : { "x" : 818, "y" : 1632 } } ], "endShape" : { "a" : { "x" : 815, "y" : 1639 }, "b" : { "x" : 818, "y" : 1632 }, "c" : { "x" : 810, "y" : 1633 }, "type" : "ARROW", "centre" : { "x" : 810, "y" : 1633 } }, "reactionShape" : { "c" : { "x" : 802, "y" : 1643 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 802, "y" : 1643 } }, "inputs" : [ { "id" : 133017, "points" : [ { "x" : 953, "y" : 1717 } ] }, { "id" : 133018, "points" : [ { "x" : 785, "y" : 1632 } ] } ], "outputs" : [ { "id" : 133019 } ] }, { "id" : 133273, "reactomeId" : 10434166, "displayName" : "HRH2 binds HRH2 antagonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 704, "y" : 2732 }, "minX" : 682, "maxX" : 720, "minY" : 2726, "maxY" : 2745, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 688, "y" : 2739 }, "to" : { "x" : 704, "y" : 2732 } }, { "from" : { "x" : 704, "y" : 2732 }, "to" : { "x" : 720, "y" : 2726 } } ], "endShape" : { "a" : { "x" : 715, "y" : 2732 }, "b" : { "x" : 720, "y" : 2726 }, "c" : { "x" : 712, "y" : 2725 }, "type" : "ARROW", "centre" : { "x" : 712, "y" : 2725 } }, "reactionShape" : { "c" : { "x" : 704, "y" : 2732 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 704, "y" : 2732 } }, "inputs" : [ { "id" : 132934, "points" : [ { "x" : 649, "y" : 2714 } ] }, { "id" : 133274, "points" : [ { "x" : 688, "y" : 2760 } ] } ], "outputs" : [ { "id" : 133275 } ] }, { "id" : 132766, "reactomeId" : 10356492, "displayName" : "Receptor CXCR6 binds CXCL16 ligand", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1775, "y" : 397 }, "minX" : 1754, "maxX" : 1802, "minY" : 382, "maxY" : 403, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1754, "y" : 396 }, "to" : { "x" : 1775, "y" : 397 } }, { "from" : { "x" : 1775, "y" : 397 }, "to" : { "x" : 1802, "y" : 382 } } ], "endShape" : { "a" : { "x" : 1798, "y" : 389 }, "b" : { "x" : 1802, "y" : 382 }, "c" : { "x" : 1794, "y" : 382 }, "type" : "ARROW", "centre" : { "x" : 1794, "y" : 382 } }, "reactionShape" : { "c" : { "x" : 1775, "y" : 397 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1775, "y" : 397 } }, "inputs" : [ { "id" : 132767, "points" : [ { "x" : 1741, "y" : 385 } ] }, { "id" : 132768, "points" : [ { "x" : 1734, "y" : 406 } ] } ], "outputs" : [ { "id" : 132769 } ] }, { "id" : 133279, "reactomeId" : 10434184, "displayName" : "HRH3 binds pitosilant", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2469, "y" : 2748 }, "minX" : 2432, "maxX" : 2475, "minY" : 2723, "maxY" : 2754, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2469, "y" : 2747 }, "to" : { "x" : 2469, "y" : 2748 } }, { "from" : { "x" : 2469, "y" : 2748 }, "to" : { "x" : 2432, "y" : 2723 } } ], "endShape" : { "a" : { "x" : 2440, "y" : 2724 }, "b" : { "x" : 2432, "y" : 2723 }, "c" : { "x" : 2436, "y" : 2730 }, "type" : "ARROW", "centre" : { "x" : 2436, "y" : 2730 } }, "reactionShape" : { "c" : { "x" : 2469, "y" : 2748 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2469, "y" : 2748 } }, "inputs" : [ { "id" : 133277, "points" : [ { "x" : 2490, "y" : 2714 } ] }, { "id" : 133280, "points" : [ { "x" : 2469, "y" : 2773 } ] } ], "outputs" : [ { "id" : 133281 } ] }, { "id" : 133276, "reactomeId" : 10434188, "displayName" : "HRH3 binds Hist", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2574, "y" : 2757 }, "minX" : 2568, "maxX" : 2583, "minY" : 2712, "maxY" : 2763, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2576, "y" : 2757 }, "to" : { "x" : 2574, "y" : 2757 } }, { "from" : { "x" : 2574, "y" : 2757 }, "to" : { "x" : 2583, "y" : 2712 } } ], "endShape" : { "a" : { "x" : 2586, "y" : 2720 }, "b" : { "x" : 2583, "y" : 2712 }, "c" : { "x" : 2578, "y" : 2718 }, "type" : "ARROW", "centre" : { "x" : 2578, "y" : 2718 } }, "reactionShape" : { "c" : { "x" : 2574, "y" : 2757 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2574, "y" : 2757 } }, "inputs" : [ { "id" : 133277, "points" : [ { "x" : 2512, "y" : 2714 } ] }, { "id" : 132939, "points" : [ { "x" : 2592, "y" : 2814 } ] } ], "outputs" : [ { "id" : 133278 } ] }, { "id" : 133020, "reactomeId" : 10361918, "displayName" : "P2Y2 receptor binds ATP and UTP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1784, "y" : 1644 }, "minX" : 1765, "maxX" : 1802, "minY" : 1634, "maxY" : 1650, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1765, "y" : 1644 }, "to" : { "x" : 1784, "y" : 1644 } }, { "from" : { "x" : 1784, "y" : 1644 }, "to" : { "x" : 1802, "y" : 1634 } } ], "endShape" : { "a" : { "x" : 1798, "y" : 1641 }, "b" : { "x" : 1802, "y" : 1634 }, "c" : { "x" : 1794, "y" : 1634 }, "type" : "ARROW", "centre" : { "x" : 1794, "y" : 1634 } }, "reactionShape" : { "c" : { "x" : 1784, "y" : 1644 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1784, "y" : 1644 } }, "inputs" : [ { "id" : 133021, "points" : [ { "x" : 1721, "y" : 1732 } ] }, { "id" : 133022, "points" : [ { "x" : 1751, "y" : 1636 } ] } ], "outputs" : [ { "id" : 133023 } ] }, { "id" : 132770, "reactomeId" : 10356364, "displayName" : "Receptors CCR1, 2 and 8 bind CCL16 ligand", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2370, "y" : 408 }, "minX" : 2350, "maxX" : 2400, "minY" : 392, "maxY" : 414, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2350, "y" : 410 }, "to" : { "x" : 2370, "y" : 408 } }, { "from" : { "x" : 2370, "y" : 408 }, "to" : { "x" : 2400, "y" : 392 } } ], "endShape" : { "a" : { "x" : 2396, "y" : 399 }, "b" : { "x" : 2400, "y" : 392 }, "c" : { "x" : 2392, "y" : 392 }, "type" : "ARROW", "centre" : { "x" : 2392, "y" : 392 } }, "reactionShape" : { "c" : { "x" : 2370, "y" : 408 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2370, "y" : 408 } }, "inputs" : [ { "id" : 132771, "points" : [ { "x" : 2323, "y" : 393 } ] }, { "id" : 132772, "points" : [ { "x" : 2336, "y" : 419 } ] } ], "outputs" : [ { "id" : 132773 } ] }, { "id" : 133282, "reactomeId" : 10434248, "displayName" : "HTR1A binds 5HT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2592, "y" : 2479 }, "minX" : 2578, "maxX" : 2613, "minY" : 2473, "maxY" : 2485, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2607, "y" : 2479 }, "to" : { "x" : 2592, "y" : 2479 } }, { "from" : { "x" : 2592, "y" : 2479 }, "to" : { "x" : 2578, "y" : 2479 } } ], "endShape" : { "a" : { "x" : 2585, "y" : 2475 }, "b" : { "x" : 2578, "y" : 2479 }, "c" : { "x" : 2585, "y" : 2483 }, "type" : "ARROW", "centre" : { "x" : 2585, "y" : 2483 } }, "reactionShape" : { "c" : { "x" : 2592, "y" : 2479 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2592, "y" : 2479 } }, "inputs" : [ { "id" : 133283, "points" : [ { "x" : 2657, "y" : 2479 } ] }, { "id" : 133284, "points" : [ { "x" : 2607, "y" : 2449 } ] } ], "outputs" : [ { "id" : 133285 } ] }, { "id" : 133024, "reactomeId" : 10361903, "displayName" : "P2RY12 binds ADP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1142, "y" : 1667 }, "minX" : 1136, "maxX" : 1191, "minY" : 1631, "maxY" : 1673, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1142, "y" : 1666 }, "to" : { "x" : 1142, "y" : 1667 } }, { "from" : { "x" : 1142, "y" : 1667 }, "to" : { "x" : 1191, "y" : 1631 } } ], "endShape" : { "a" : { "x" : 1188, "y" : 1638 }, "b" : { "x" : 1191, "y" : 1631 }, "c" : { "x" : 1183, "y" : 1632 }, "type" : "ARROW", "centre" : { "x" : 1183, "y" : 1632 } }, "reactionShape" : { "c" : { "x" : 1142, "y" : 1667 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1142, "y" : 1667 } }, "inputs" : [ { "id" : 133025, "points" : [ { "x" : 1125, "y" : 1628 } ] }, { "id" : 133017, "points" : [ { "x" : 999, "y" : 1717 } ] } ], "outputs" : [ { "id" : 133026 } ], "inhibitors" : [ { "id" : 133027, "points" : [ { "x" : 1050, "y" : 1623 } ] } ] }, { "id" : 133286, "reactomeId" : 10433340, "displayName" : "HTR1A binds HTR1A antagonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2833, "y" : 2425 }, "minX" : 2827, "maxX" : 2914, "minY" : 2419, "maxY" : 2457, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2833, "y" : 2423 }, "to" : { "x" : 2833, "y" : 2425 } }, { "from" : { "x" : 2833, "y" : 2425 }, "to" : { "x" : 2914, "y" : 2457 } } ], "endShape" : { "a" : { "x" : 2906, "y" : 2458 }, "b" : { "x" : 2914, "y" : 2457 }, "c" : { "x" : 2909, "y" : 2451 }, "type" : "ARROW", "centre" : { "x" : 2909, "y" : 2451 } }, "reactionShape" : { "c" : { "x" : 2833, "y" : 2425 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2833, "y" : 2425 } }, "inputs" : [ { "id" : 133283, "points" : [ { "x" : 2713, "y" : 2469 } ] }, { "id" : 133287, "points" : [ { "x" : 2833, "y" : 2405 } ] } ], "outputs" : [ { "id" : 133288 } ] }, { "id" : 132774, "reactomeId" : 10356324, "displayName" : "Receptors CCR3, 4 and 5 bind CCL5 ligand", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2769, "y" : 399 }, "minX" : 2745, "maxX" : 2789, "minY" : 391, "maxY" : 405, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2745, "y" : 399 }, "to" : { "x" : 2769, "y" : 399 } }, { "from" : { "x" : 2769, "y" : 399 }, "to" : { "x" : 2789, "y" : 391 } } ], "endShape" : { "a" : { "x" : 2784, "y" : 397 }, "b" : { "x" : 2789, "y" : 391 }, "c" : { "x" : 2781, "y" : 390 }, "type" : "ARROW", "centre" : { "x" : 2781, "y" : 390 } }, "reactionShape" : { "c" : { "x" : 2769, "y" : 399 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2769, "y" : 399 } }, "inputs" : [ { "id" : 132775, "points" : [ { "x" : 2726, "y" : 386 } ] }, { "id" : 132776, "points" : [ { "x" : 2726, "y" : 413 } ] } ], "outputs" : [ { "id" : 132777 } ] }, { "id" : 133028, "reactomeId" : 10361899, "displayName" : "P2Y11 receptor can bind to ATP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2438, "y" : 1643 }, "minX" : 2420, "maxX" : 2457, "minY" : 1634, "maxY" : 1649, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2420, "y" : 1644 }, "to" : { "x" : 2438, "y" : 1643 } }, { "from" : { "x" : 2438, "y" : 1643 }, "to" : { "x" : 2457, "y" : 1634 } } ], "endShape" : { "a" : { "x" : 2452, "y" : 1641 }, "b" : { "x" : 2457, "y" : 1634 }, "c" : { "x" : 2449, "y" : 1633 }, "type" : "ARROW", "centre" : { "x" : 2449, "y" : 1633 } }, "reactionShape" : { "c" : { "x" : 2438, "y" : 1643 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2438, "y" : 1643 } }, "inputs" : [ { "id" : 133029, "points" : [ { "x" : 2405, "y" : 1634 } ] }, { "id" : 133030, "points" : [ { "x" : 2399, "y" : 1652 } ] } ], "outputs" : [ { "id" : 133031 } ] }, { "id" : 132778, "reactomeId" : 10365067, "displayName" : "Receptor ACKR2 binds most inflammatory CC chemokines", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 606, "y" : 549 }, "minX" : 587, "maxX" : 633, "minY" : 543, "maxY" : 558, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 587, "y" : 550 }, "to" : { "x" : 606, "y" : 549 } }, { "from" : { "x" : 606, "y" : 549 }, "to" : { "x" : 633, "y" : 558 } } ], "endShape" : { "a" : { "x" : 625, "y" : 560 }, "b" : { "x" : 633, "y" : 558 }, "c" : { "x" : 628, "y" : 552 }, "type" : "ARROW", "centre" : { "x" : 628, "y" : 552 } }, "reactionShape" : { "c" : { "x" : 606, "y" : 549 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 606, "y" : 549 } }, "inputs" : [ { "id" : 132779, "points" : [ { "x" : 579, "y" : 536 } ] }, { "id" : 132780, "points" : [ { "x" : 572, "y" : 566 } ] } ], "outputs" : [ { "id" : 132781 } ] }, { "id" : 133032, "reactomeId" : 10361914, "displayName" : "P2Y4 receptor can bind to UTP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 662, "y" : 1638 }, "minX" : 642, "maxX" : 685, "minY" : 1627, "maxY" : 1644, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 642, "y" : 1638 }, "to" : { "x" : 662, "y" : 1638 } }, { "from" : { "x" : 662, "y" : 1638 }, "to" : { "x" : 685, "y" : 1627 } } ], "endShape" : { "a" : { "x" : 680, "y" : 1634 }, "b" : { "x" : 685, "y" : 1627 }, "c" : { "x" : 677, "y" : 1626 }, "type" : "ARROW", "centre" : { "x" : 677, "y" : 1626 } }, "reactionShape" : { "c" : { "x" : 662, "y" : 1638 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 662, "y" : 1638 } }, "inputs" : [ { "id" : 133033, "points" : [ { "x" : 626, "y" : 1629 } ] }, { "id" : 133034, "points" : [ { "x" : 574, "y" : 1730 } ] } ], "outputs" : [ { "id" : 133035 } ] }, { "id" : 133289, "reactomeId" : 10434252, "displayName" : "HTR1A binds HTR1A agonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2708, "y" : 2415 }, "minX" : 2702, "maxX" : 2779, "minY" : 2409, "maxY" : 2459, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2707, "y" : 2415 }, "to" : { "x" : 2708, "y" : 2415 } }, { "from" : { "x" : 2708, "y" : 2415 }, "to" : { "x" : 2779, "y" : 2459 } } ], "endShape" : { "a" : { "x" : 2771, "y" : 2459 }, "b" : { "x" : 2779, "y" : 2459 }, "c" : { "x" : 2775, "y" : 2452 }, "type" : "ARROW", "centre" : { "x" : 2775, "y" : 2452 } }, "reactionShape" : { "c" : { "x" : 2708, "y" : 2415 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2708, "y" : 2415 } }, "inputs" : [ { "id" : 133290, "points" : [ { "x" : 2707, "y" : 2373 } ] }, { "id" : 133283, "points" : [ { "x" : 2688, "y" : 2465 } ] } ], "outputs" : [ { "id" : 133291 } ] }, { "id" : 132782, "reactomeId" : 10365027, "displayName" : "Receptor CCR11 binds CCL19, CCL21 & CCL25", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3935, "y" : 63 }, "minX" : 3909, "maxX" : 3961, "minY" : 57, "maxY" : 73, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3909, "y" : 62 }, "to" : { "x" : 3935, "y" : 63 } }, { "from" : { "x" : 3935, "y" : 63 }, "to" : { "x" : 3961, "y" : 73 } } ], "endShape" : { "a" : { "x" : 3953, "y" : 74 }, "b" : { "x" : 3961, "y" : 73 }, "c" : { "x" : 3956, "y" : 67 }, "type" : "ARROW", "centre" : { "x" : 3956, "y" : 67 } }, "reactionShape" : { "c" : { "x" : 3935, "y" : 63 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3935, "y" : 63 } }, "inputs" : [ { "id" : 132783, "points" : [ { "x" : 3901, "y" : 53 } ] }, { "id" : 132784, "points" : [ { "x" : 3884, "y" : 73 } ] } ], "outputs" : [ { "id" : 132785 } ] }, { "id" : 133295, "reactomeId" : 10434567, "displayName" : "CHRM1,3,5 bind CHRM1,3,5 antagonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1109, "y" : 2764 }, "minX" : 1103, "maxX" : 1147, "minY" : 2727, "maxY" : 2770, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1109, "y" : 2763 }, "to" : { "x" : 1109, "y" : 2764 } }, { "from" : { "x" : 1109, "y" : 2764 }, "to" : { "x" : 1147, "y" : 2727 } } ], "endShape" : { "a" : { "x" : 1145, "y" : 2735 }, "b" : { "x" : 1147, "y" : 2727 }, "c" : { "x" : 1139, "y" : 2729 }, "type" : "ARROW", "centre" : { "x" : 1139, "y" : 2729 } }, "reactionShape" : { "c" : { "x" : 1109, "y" : 2764 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1109, "y" : 2764 } }, "inputs" : [ { "id" : 133296, "points" : [ { "x" : 1109, "y" : 2802 } ] }, { "id" : 132908, "points" : [ { "x" : 1052, "y" : 2725 } ] } ], "outputs" : [ { "id" : 133297 } ] }, { "id" : 133036, "reactomeId" : 10361912, "displayName" : "P2Y6 receptor can bind to UDP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3544, "y" : 1672 }, "minX" : 3512, "maxX" : 3561, "minY" : 1644, "maxY" : 1678, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3512, "y" : 1673 }, "to" : { "x" : 3544, "y" : 1672 } }, { "from" : { "x" : 3544, "y" : 1672 }, "to" : { "x" : 3561, "y" : 1644 } } ], "endShape" : { "a" : { "x" : 3561, "y" : 1652 }, "b" : { "x" : 3561, "y" : 1644 }, "c" : { "x" : 3554, "y" : 1648 }, "type" : "ARROW", "centre" : { "x" : 3554, "y" : 1648 } }, "reactionShape" : { "c" : { "x" : 3544, "y" : 1672 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3544, "y" : 1672 } }, "inputs" : [ { "id" : 133037, "points" : [ { "x" : 3493, "y" : 1636 } ] }, { "id" : 133038, "points" : [ { "x" : 3403, "y" : 1720 } ] } ], "outputs" : [ { "id" : 133039 } ] }, { "id" : 133292, "reactomeId" : 10434391, "displayName" : "CNRs bind CNR agonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3147, "y" : 2409 }, "minX" : 3123, "maxX" : 3153, "minY" : 2403, "maxY" : 2454, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3146, "y" : 2408 }, "to" : { "x" : 3147, "y" : 2409 } }, { "from" : { "x" : 3147, "y" : 2409 }, "to" : { "x" : 3123, "y" : 2454 } } ], "endShape" : { "a" : { "x" : 3123, "y" : 2446 }, "b" : { "x" : 3123, "y" : 2454 }, "c" : { "x" : 3130, "y" : 2450 }, "type" : "ARROW", "centre" : { "x" : 3130, "y" : 2450 } }, "reactionShape" : { "c" : { "x" : 3147, "y" : 2409 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3147, "y" : 2409 } }, "inputs" : [ { "id" : 133064, "points" : [ { "x" : 3197, "y" : 2457 } ] }, { "id" : 133293, "points" : [ { "x" : 3146, "y" : 2376 } ] } ], "outputs" : [ { "id" : 133294 } ] }, { "id" : 132786, "reactomeId" : 10365177, "displayName" : "CXCR5 binds CXCL13", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3707, "y" : 395 }, "minX" : 3690, "maxX" : 3731, "minY" : 385, "maxY" : 401, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3690, "y" : 396 }, "to" : { "x" : 3707, "y" : 395 } }, { "from" : { "x" : 3707, "y" : 395 }, "to" : { "x" : 3731, "y" : 385 } } ], "endShape" : { "a" : { "x" : 3726, "y" : 391 }, "b" : { "x" : 3731, "y" : 385 }, "c" : { "x" : 3723, "y" : 384 }, "type" : "ARROW", "centre" : { "x" : 3723, "y" : 384 } }, "reactionShape" : { "c" : { "x" : 3707, "y" : 395 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3707, "y" : 395 } }, "inputs" : [ { "id" : 132787, "points" : [ { "x" : 3671, "y" : 405 } ] }, { "id" : 132788, "points" : [ { "x" : 3675, "y" : 391 } ] } ], "outputs" : [ { "id" : 132789 } ] }, { "id" : 133298, "reactomeId" : 10434571, "displayName" : "CHRM2 binds CHRM2 antagonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3484, "y" : 2747 }, "minX" : 3478, "maxX" : 3518, "minY" : 2726, "maxY" : 2753, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3483, "y" : 2747 }, "to" : { "x" : 3484, "y" : 2747 } }, { "from" : { "x" : 3484, "y" : 2747 }, "to" : { "x" : 3518, "y" : 2726 } } ], "endShape" : { "a" : { "x" : 3514, "y" : 2733 }, "b" : { "x" : 3518, "y" : 2726 }, "c" : { "x" : 3510, "y" : 2726 }, "type" : "ARROW", "centre" : { "x" : 3510, "y" : 2726 } }, "reactionShape" : { "c" : { "x" : 3484, "y" : 2747 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3484, "y" : 2747 } }, "inputs" : [ { "id" : 133299, "points" : [ { "x" : 3483, "y" : 2776 } ] }, { "id" : 133300, "points" : [ { "x" : 3455, "y" : 2716 } ] } ], "outputs" : [ { "id" : 133301 } ] }, { "id" : 133042, "reactomeId" : 10361910, "displayName" : "P2Y5 receptor can bind to LPA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1959, "y" : 1640 }, "minX" : 1942, "maxX" : 1983, "minY" : 1630, "maxY" : 1646, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1942, "y" : 1641 }, "to" : { "x" : 1959, "y" : 1640 } }, { "from" : { "x" : 1959, "y" : 1640 }, "to" : { "x" : 1983, "y" : 1630 } } ], "endShape" : { "a" : { "x" : 1978, "y" : 1636 }, "b" : { "x" : 1983, "y" : 1630 }, "c" : { "x" : 1975, "y" : 1629 }, "type" : "ARROW", "centre" : { "x" : 1975, "y" : 1629 } }, "reactionShape" : { "c" : { "x" : 1959, "y" : 1640 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1959, "y" : 1640 } }, "inputs" : [ { "id" : 133043, "points" : [ { "x" : 1924, "y" : 1633 } ] }, { "id" : 133044, "points" : [ { "x" : 1927, "y" : 1656 } ] } ], "outputs" : [ { "id" : 133045 } ] }, { "id" : 133040, "reactomeId" : 10362149, "displayName" : "The UDP/CysLT (P2Y17) receptor can bind UTP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3365, "y" : 1684 }, "minX" : 3301, "maxX" : 3398, "minY" : 1635, "maxY" : 1690, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3301, "y" : 1684 }, "to" : { "x" : 3365, "y" : 1684 } }, { "from" : { "x" : 3365, "y" : 1684 }, "to" : { "x" : 3398, "y" : 1635 } } ], "endShape" : { "a" : { "x" : 3397, "y" : 1643 }, "b" : { "x" : 3398, "y" : 1635 }, "c" : { "x" : 3391, "y" : 1639 }, "type" : "ARROW", "centre" : { "x" : 3391, "y" : 1639 } }, "reactionShape" : { "c" : { "x" : 3365, "y" : 1684 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3365, "y" : 1684 } }, "inputs" : [ { "id" : 133009, "points" : [ { "x" : 3234, "y" : 1633 } ] }, { "id" : 133038, "points" : [ { "x" : 3353, "y" : 1713 } ] } ], "outputs" : [ { "id" : 133041 } ] }, { "id" : 132790, "reactomeId" : 10356911, "displayName" : "Somatostatin receptors bind somatostatin and cortistatin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3035, "y" : 71 }, "minX" : 3029, "maxX" : 3066, "minY" : 65, "maxY" : 77, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3035, "y" : 70 }, "to" : { "x" : 3035, "y" : 71 } }, { "from" : { "x" : 3035, "y" : 71 }, "to" : { "x" : 3066, "y" : 73 } } ], "endShape" : { "a" : { "x" : 3059, "y" : 77 }, "b" : { "x" : 3066, "y" : 73 }, "c" : { "x" : 3059, "y" : 69 }, "type" : "ARROW", "centre" : { "x" : 3059, "y" : 69 } }, "reactionShape" : { "c" : { "x" : 3035, "y" : 71 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3035, "y" : 71 } }, "inputs" : [ { "id" : 132791, "points" : [ { "x" : 3004, "y" : 47 } ] }, { "id" : 132792, "points" : [ { "x" : 3005, "y" : 77 } ] } ], "outputs" : [ { "id" : 132793 } ] }, { "id" : 133302, "reactomeId" : 10435561, "displayName" : "PTGFR binds PTGFR agonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1585, "y" : 2410 }, "minX" : 1551, "maxX" : 1591, "minY" : 2404, "maxY" : 2461, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1585, "y" : 2409 }, "to" : { "x" : 1585, "y" : 2410 } }, { "from" : { "x" : 1585, "y" : 2410 }, "to" : { "x" : 1551, "y" : 2461 } } ], "endShape" : { "a" : { "x" : 1552, "y" : 2453 }, "b" : { "x" : 1551, "y" : 2461 }, "c" : { "x" : 1558, "y" : 2457 }, "type" : "ARROW", "centre" : { "x" : 1558, "y" : 2457 } }, "reactionShape" : { "c" : { "x" : 1585, "y" : 2410 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1585, "y" : 2410 } }, "inputs" : [ { "id" : 132983, "points" : [ { "x" : 1623, "y" : 2465 } ] }, { "id" : 133303, "points" : [ { "x" : 1577, "y" : 2379 } ] } ], "outputs" : [ { "id" : 133304 } ] }, { "id" : 133046, "reactomeId" : 10361897, "displayName" : "P2Y9 receptor can bind to LPA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2103, "y" : 1645 }, "minX" : 2091, "maxX" : 2128, "minY" : 1631, "maxY" : 1651, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2091, "y" : 1648 }, "to" : { "x" : 2103, "y" : 1645 } }, { "from" : { "x" : 2103, "y" : 1645 }, "to" : { "x" : 2128, "y" : 1631 } } ], "endShape" : { "a" : { "x" : 2124, "y" : 1638 }, "b" : { "x" : 2128, "y" : 1631 }, "c" : { "x" : 2120, "y" : 1631 }, "type" : "ARROW", "centre" : { "x" : 2120, "y" : 1631 } }, "reactionShape" : { "c" : { "x" : 2103, "y" : 1645 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2103, "y" : 1645 } }, "inputs" : [ { "id" : 133047, "points" : [ { "x" : 2082, "y" : 1637 } ] }, { "id" : 133044, "points" : [ { "x" : 1939, "y" : 1670 } ] } ], "outputs" : [ { "id" : 133048 } ] }, { "id" : 132794, "reactomeId" : 10359045, "displayName" : "Tachykinin receptor 1 (NK1) binds to substance P", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 624, "y" : 400 }, "minX" : 602, "maxX" : 642, "minY" : 388, "maxY" : 406, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 602, "y" : 399 }, "to" : { "x" : 624, "y" : 400 } }, { "from" : { "x" : 624, "y" : 400 }, "to" : { "x" : 642, "y" : 388 } } ], "endShape" : { "a" : { "x" : 638, "y" : 395 }, "b" : { "x" : 642, "y" : 388 }, "c" : { "x" : 634, "y" : 389 }, "type" : "ARROW", "centre" : { "x" : 634, "y" : 389 } }, "reactionShape" : { "c" : { "x" : 624, "y" : 400 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 624, "y" : 400 } }, "inputs" : [ { "id" : 132795, "points" : [ { "x" : 587, "y" : 409 } ] }, { "id" : 132796, "points" : [ { "x" : 586, "y" : 388 } ] } ], "outputs" : [ { "id" : 132797 } ] }, { "id" : 133305, "reactomeId" : 10435565, "displayName" : "GNRHR binds GNRHR peptide agonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1640, "y" : 2753 }, "minX" : 1606, "maxX" : 1646, "minY" : 2724, "maxY" : 2759, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1640, "y" : 2752 }, "to" : { "x" : 1640, "y" : 2753 } }, { "from" : { "x" : 1640, "y" : 2753 }, "to" : { "x" : 1606, "y" : 2724 } } ], "endShape" : { "a" : { "x" : 1614, "y" : 2725 }, "b" : { "x" : 1606, "y" : 2724 }, "c" : { "x" : 1609, "y" : 2732 }, "type" : "ARROW", "centre" : { "x" : 1609, "y" : 2732 } }, "reactionShape" : { "c" : { "x" : 1640, "y" : 2753 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1640, "y" : 2753 } }, "inputs" : [ { "id" : 132961, "points" : [ { "x" : 1806, "y" : 2717 }, { "x" : 1744, "y" : 2752 } ] }, { "id" : 133306, "points" : [ { "x" : 1640, "y" : 2789 } ] } ], "outputs" : [ { "id" : 133307 } ] }, { "id" : 133049, "reactomeId" : 10361906, "displayName" : "P2Y10 receptor can bind to LPA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2269, "y" : 1659 }, "minX" : 2243, "maxX" : 2291, "minY" : 1641, "maxY" : 1665, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2243, "y" : 1659 }, "to" : { "x" : 2269, "y" : 1659 } }, { "from" : { "x" : 2269, "y" : 1659 }, "to" : { "x" : 2291, "y" : 1641 } } ], "endShape" : { "a" : { "x" : 2288, "y" : 1648 }, "b" : { "x" : 2291, "y" : 1641 }, "c" : { "x" : 2283, "y" : 1642 }, "type" : "ARROW", "centre" : { "x" : 2283, "y" : 1642 } }, "reactionShape" : { "c" : { "x" : 2269, "y" : 1659 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2269, "y" : 1659 } }, "inputs" : [ { "id" : 133050, "points" : [ { "x" : 2235, "y" : 1636 } ] }, { "id" : 133044, "points" : [ { "x" : 1939, "y" : 1673 } ] } ], "outputs" : [ { "id" : 133051 } ] }, { "id" : 132798, "reactomeId" : 10360194, "displayName" : "Tachykinin receptor 2 (NK2) binds to nuerokinin A", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 171, "y" : 116 }, "minX" : 150, "maxX" : 187, "minY" : 83, "maxY" : 144, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 156, "y" : 89 }, "to" : { "x" : 171, "y" : 116 } }, { "from" : { "x" : 171, "y" : 116 }, "to" : { "x" : 187, "y" : 144 } } ], "endShape" : { "a" : { "x" : 180, "y" : 140 }, "b" : { "x" : 187, "y" : 144 }, "c" : { "x" : 187, "y" : 136 }, "type" : "ARROW", "centre" : { "x" : 187, "y" : 136 } }, "reactionShape" : { "c" : { "x" : 171, "y" : 116 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 171, "y" : 116 } }, "inputs" : [ { "id" : 132799, "points" : [ { "x" : 188, "y" : 48 } ] }, { "id" : 132800, "points" : [ { "x" : 180, "y" : 89 } ] } ], "outputs" : [ { "id" : 132801 } ] }, { "id" : 133311, "reactomeId" : 10435569, "displayName" : "GNRHR binds chemical antagonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1983, "y" : 2764 }, "minX" : 1953, "maxX" : 2019, "minY" : 2719, "maxY" : 2804, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1953, "y" : 2804 }, "to" : { "x" : 1983, "y" : 2764 } }, { "from" : { "x" : 1983, "y" : 2764 }, "to" : { "x" : 2013, "y" : 2725 } } ], "endShape" : { "a" : { "x" : 2012, "y" : 2733 }, "b" : { "x" : 2013, "y" : 2725 }, "c" : { "x" : 2006, "y" : 2728 }, "type" : "ARROW", "centre" : { "x" : 2006, "y" : 2728 } }, "reactionShape" : { "c" : { "x" : 1983, "y" : 2764 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1983, "y" : 2764 } }, "inputs" : [ { "id" : 132961, "points" : [ { "x" : 1838, "y" : 2717 } ] }, { "id" : 133312, "points" : [ { "x" : 1912, "y" : 2838 }, { "x" : 1824, "y" : 2804 } ] } ], "outputs" : [ { "id" : 133313 } ] }, { "id" : 133308, "reactomeId" : 10435573, "displayName" : "GNRHR binds GNRHR peptide antagonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1752, "y" : 2752 }, "minX" : 1728, "maxX" : 1783, "minY" : 2724, "maxY" : 2786, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1777, "y" : 2780 }, "to" : { "x" : 1752, "y" : 2752 } }, { "from" : { "x" : 1752, "y" : 2752 }, "to" : { "x" : 1728, "y" : 2724 } } ], "endShape" : { "a" : { "x" : 1736, "y" : 2727 }, "b" : { "x" : 1728, "y" : 2724 }, "c" : { "x" : 1729, "y" : 2732 }, "type" : "ARROW", "centre" : { "x" : 1729, "y" : 2732 } }, "reactionShape" : { "c" : { "x" : 1752, "y" : 2752 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1752, "y" : 2752 } }, "inputs" : [ { "id" : 133309, "points" : [ { "x" : 1777, "y" : 2826 } ] }, { "id" : 132961, "points" : [ { "x" : 1817, "y" : 2717 } ] } ], "outputs" : [ { "id" : 133310 } ] }, { "id" : 133052, "reactomeId" : 10361908, "displayName" : "P2Y14 receptor can bind to UDP-glucose", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2653, "y" : 1650 }, "minX" : 2628, "maxX" : 2672, "minY" : 1639, "maxY" : 1656, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2628, "y" : 1650 }, "to" : { "x" : 2653, "y" : 1650 } }, { "from" : { "x" : 2653, "y" : 1650 }, "to" : { "x" : 2672, "y" : 1639 } } ], "endShape" : { "a" : { "x" : 2668, "y" : 1646 }, "b" : { "x" : 2672, "y" : 1639 }, "c" : { "x" : 2664, "y" : 1639 }, "type" : "ARROW", "centre" : { "x" : 2664, "y" : 1639 } }, "reactionShape" : { "c" : { "x" : 2653, "y" : 1650 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2653, "y" : 1650 } }, "inputs" : [ { "id" : 133053, "points" : [ { "x" : 2611, "y" : 1639 } ] }, { "id" : 133054, "points" : [ { "x" : 2615, "y" : 1654 } ] } ], "outputs" : [ { "id" : 133055 } ] }, { "id" : 132802, "reactomeId" : 10360196, "displayName" : "Tachykinin receptor 3 (NK3) binds to neurokinin B", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2385, "y" : 560 }, "minX" : 2366, "maxX" : 2408, "minY" : 554, "maxY" : 566, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2366, "y" : 561 }, "to" : { "x" : 2385, "y" : 560 } }, { "from" : { "x" : 2385, "y" : 560 }, "to" : { "x" : 2408, "y" : 563 } } ], "endShape" : { "a" : { "x" : 2401, "y" : 566 }, "b" : { "x" : 2408, "y" : 563 }, "c" : { "x" : 2402, "y" : 558 }, "type" : "ARROW", "centre" : { "x" : 2402, "y" : 558 } }, "reactionShape" : { "c" : { "x" : 2385, "y" : 560 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2385, "y" : 560 } }, "inputs" : [ { "id" : 132803, "points" : [ { "x" : 2353, "y" : 568 } ] }, { "id" : 132804, "points" : [ { "x" : 2354, "y" : 554 } ] } ], "outputs" : [ { "id" : 132805 } ] }, { "id" : 133314, "reactomeId" : 10435747, "displayName" : "EDNRA, EDNRB bind non-selective ERAs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1821, "y" : 2416 }, "minX" : 1808, "maxX" : 1827, "minY" : 2410, "maxY" : 2451, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1821, "y" : 2415 }, "to" : { "x" : 1821, "y" : 2416 } }, { "from" : { "x" : 1821, "y" : 2416 }, "to" : { "x" : 1808, "y" : 2451 } } ], "endShape" : { "a" : { "x" : 1807, "y" : 2443 }, "b" : { "x" : 1808, "y" : 2451 }, "c" : { "x" : 1814, "y" : 2446 }, "type" : "ARROW", "centre" : { "x" : 1814, "y" : 2446 } }, "reactionShape" : { "c" : { "x" : 1821, "y" : 2416 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1821, "y" : 2416 } }, "inputs" : [ { "id" : 133315, "points" : [ { "x" : 1821, "y" : 2385 } ] }, { "id" : 132824, "points" : [ { "x" : 1889, "y" : 2459 } ] } ], "outputs" : [ { "id" : 133316 } ] }, { "id" : 133056, "reactomeId" : 10362147, "displayName" : "A1 and A3 receptors bind adenosine", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3708, "y" : 1641 }, "minX" : 3694, "maxX" : 3717, "minY" : 1638, "maxY" : 1651, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3700, "y" : 1645 }, "to" : { "x" : 3708, "y" : 1641 } }, { "from" : { "x" : 3708, "y" : 1641 }, "to" : { "x" : 3717, "y" : 1638 } } ], "endShape" : { "a" : { "x" : 3712, "y" : 1644 }, "b" : { "x" : 3717, "y" : 1638 }, "c" : { "x" : 3709, "y" : 1636 }, "type" : "ARROW", "centre" : { "x" : 3709, "y" : 1636 } }, "reactionShape" : { "c" : { "x" : 3708, "y" : 1641 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3708, "y" : 1641 } }, "inputs" : [ { "id" : 133057, "points" : [ { "x" : 3683, "y" : 1653 } ] }, { "id" : 133058, "points" : [ { "x" : 3677, "y" : 1640 } ] } ], "outputs" : [ { "id" : 133059 } ] }, { "id" : 132806, "reactomeId" : 10360198, "displayName" : "AVP(20-28) binds AVPR1A,B", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 98, "y" : 2583 }, "minX" : 92, "maxX" : 128, "minY" : 2577, "maxY" : 2591, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 97, "y" : 2582 }, "to" : { "x" : 98, "y" : 2583 } }, { "from" : { "x" : 98, "y" : 2583 }, "to" : { "x" : 128, "y" : 2591 } } ], "endShape" : { "a" : { "x" : 120, "y" : 2593 }, "b" : { "x" : 128, "y" : 2591 }, "c" : { "x" : 122, "y" : 2585 }, "type" : "ARROW", "centre" : { "x" : 122, "y" : 2585 } }, "reactionShape" : { "c" : { "x" : 98, "y" : 2583 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 98, "y" : 2583 } }, "inputs" : [ { "id" : 132807, "points" : [ { "x" : 155, "y" : 2539 } ] }, { "id" : 132808, "points" : [ { "x" : 82, "y" : 2557 } ] } ], "outputs" : [ { "id" : 132809 } ] }, { "id" : 133063, "reactomeId" : 10362429, "displayName" : "Cannabinoid receptors can bind cannabinoids", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3301, "y" : 2440 }, "minX" : 3282, "maxX" : 3314, "minY" : 2421, "maxY" : 2453, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3288, "y" : 2427 }, "to" : { "x" : 3301, "y" : 2440 } }, { "from" : { "x" : 3301, "y" : 2440 }, "to" : { "x" : 3314, "y" : 2453 } } ], "endShape" : { "a" : { "x" : 3306, "y" : 2451 }, "b" : { "x" : 3314, "y" : 2453 }, "c" : { "x" : 3312, "y" : 2445 }, "type" : "ARROW", "centre" : { "x" : 3312, "y" : 2445 } }, "reactionShape" : { "c" : { "x" : 3301, "y" : 2440 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3301, "y" : 2440 } }, "inputs" : [ { "id" : 133064, "points" : [ { "x" : 3227, "y" : 2457 } ] }, { "id" : 133065, "points" : [ { "x" : 3287, "y" : 2395 } ] } ], "outputs" : [ { "id" : 133066 } ] }, { "id" : 133060, "reactomeId" : 10362151, "displayName" : "ADORA2A,B bind Ade-Rib", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3866, "y" : 1662 }, "minX" : 3846, "maxX" : 3912, "minY" : 1636, "maxY" : 1668, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3846, "y" : 1663 }, "to" : { "x" : 3866, "y" : 1662 } }, { "from" : { "x" : 3866, "y" : 1662 }, "to" : { "x" : 3912, "y" : 1636 } } ], "endShape" : { "a" : { "x" : 3908, "y" : 1643 }, "b" : { "x" : 3912, "y" : 1636 }, "c" : { "x" : 3904, "y" : 1636 }, "type" : "ARROW", "centre" : { "x" : 3904, "y" : 1636 } }, "reactionShape" : { "c" : { "x" : 3866, "y" : 1662 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3866, "y" : 1662 } }, "inputs" : [ { "id" : 133057, "points" : [ { "x" : 3701, "y" : 1669 } ] }, { "id" : 133061, "points" : [ { "x" : 3841, "y" : 1638 } ] } ], "outputs" : [ { "id" : 133062 } ] }, { "id" : 133317, "reactomeId" : 10435760, "displayName" : "EDNRA binds EDNs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2118, "y" : 2411 }, "minX" : 2093, "maxX" : 2124, "minY" : 2405, "maxY" : 2457, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2117, "y" : 2409 }, "to" : { "x" : 2118, "y" : 2411 } }, { "from" : { "x" : 2118, "y" : 2411 }, "to" : { "x" : 2093, "y" : 2457 } } ], "endShape" : { "a" : { "x" : 2093, "y" : 2449 }, "b" : { "x" : 2093, "y" : 2457 }, "c" : { "x" : 2100, "y" : 2453 }, "type" : "ARROW", "centre" : { "x" : 2100, "y" : 2453 } }, "reactionShape" : { "c" : { "x" : 2118, "y" : 2411 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2118, "y" : 2411 } }, "inputs" : [ { "id" : 133318, "points" : [ { "x" : 2145, "y" : 2466 } ] }, { "id" : 132823, "points" : [ { "x" : 1976, "y" : 2377 } ] } ], "outputs" : [ { "id" : 133319 } ] }, { "id" : 132810, "reactomeId" : 10361161, "displayName" : "AVP(20-28) binds AVPR2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 281, "y" : 2745 }, "minX" : 275, "maxX" : 343, "minY" : 2722, "maxY" : 2751, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 281, "y" : 2744 }, "to" : { "x" : 281, "y" : 2745 } }, { "from" : { "x" : 281, "y" : 2745 }, "to" : { "x" : 343, "y" : 2722 } } ], "endShape" : { "a" : { "x" : 338, "y" : 2728 }, "b" : { "x" : 343, "y" : 2722 }, "c" : { "x" : 335, "y" : 2721 }, "type" : "ARROW", "centre" : { "x" : 335, "y" : 2721 } }, "reactionShape" : { "c" : { "x" : 281, "y" : 2745 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 281, "y" : 2745 } }, "inputs" : [ { "id" : 132811, "points" : [ { "x" : 254, "y" : 2752 } ] }, { "id" : 132812, "points" : [ { "x" : 239, "y" : 2715 } ] } ], "outputs" : [ { "id" : 132813 } ] }, { "id" : 133067, "reactomeId" : 10362425, "displayName" : "PAF receptor binds platelet activating factor", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2975, "y" : 2269 }, "minX" : 2954, "maxX" : 2988, "minY" : 2255, "maxY" : 2275, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2954, "y" : 2268 }, "to" : { "x" : 2975, "y" : 2269 } }, { "from" : { "x" : 2975, "y" : 2269 }, "to" : { "x" : 2988, "y" : 2255 } } ], "endShape" : { "a" : { "x" : 2986, "y" : 2263 }, "b" : { "x" : 2988, "y" : 2255 }, "c" : { "x" : 2980, "y" : 2257 }, "type" : "ARROW", "centre" : { "x" : 2980, "y" : 2257 } }, "reactionShape" : { "c" : { "x" : 2975, "y" : 2269 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2975, "y" : 2269 } }, "inputs" : [ { "id" : 133068, "points" : [ { "x" : 2935, "y" : 2250 } ] }, { "id" : 133069, "points" : [ { "x" : 2944, "y" : 2273 } ] } ], "outputs" : [ { "id" : 133070 } ] }, { "id" : 133320, "reactomeId" : 10435764, "displayName" : "EDNRA binds selective ERAs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2186, "y" : 2406 }, "minX" : 2180, "maxX" : 2228, "minY" : 2400, "maxY" : 2460, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2185, "y" : 2405 }, "to" : { "x" : 2186, "y" : 2406 } }, { "from" : { "x" : 2186, "y" : 2406 }, "to" : { "x" : 2228, "y" : 2460 } } ], "endShape" : { "a" : { "x" : 2221, "y" : 2457 }, "b" : { "x" : 2228, "y" : 2460 }, "c" : { "x" : 2227, "y" : 2452 }, "type" : "ARROW", "centre" : { "x" : 2227, "y" : 2452 } }, "reactionShape" : { "c" : { "x" : 2186, "y" : 2406 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2186, "y" : 2406 } }, "inputs" : [ { "id" : 133321, "points" : [ { "x" : 2185, "y" : 2371 } ] }, { "id" : 133318, "points" : [ { "x" : 2156, "y" : 2466 } ] } ], "outputs" : [ { "id" : 133322 } ] }, { "id" : 132814, "reactomeId" : 10360200, "displayName" : "Oxytocin receptor bind oxytocin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1224, "y" : 558 }, "minX" : 1208, "maxX" : 1244, "minY" : 552, "maxY" : 567, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1208, "y" : 558 }, "to" : { "x" : 1224, "y" : 558 } }, { "from" : { "x" : 1224, "y" : 558 }, "to" : { "x" : 1244, "y" : 567 } } ], "endShape" : { "a" : { "x" : 1236, "y" : 568 }, "b" : { "x" : 1244, "y" : 567 }, "c" : { "x" : 1239, "y" : 561 }, "type" : "ARROW", "centre" : { "x" : 1239, "y" : 561 } }, "reactionShape" : { "c" : { "x" : 1224, "y" : 558 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1224, "y" : 558 } }, "inputs" : [ { "id" : 132815, "points" : [ { "x" : 1194, "y" : 569 } ] }, { "id" : 132816, "points" : [ { "x" : 1192, "y" : 545 } ] } ], "outputs" : [ { "id" : 132817 } ] }, { "id" : 133071, "reactomeId" : 10362423, "displayName" : "Melatonin receptors can bind melatonin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 269, "y" : 1940 }, "minX" : 244, "maxX" : 292, "minY" : 1934, "maxY" : 1950, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 244, "y" : 1941 }, "to" : { "x" : 269, "y" : 1940 } }, { "from" : { "x" : 269, "y" : 1940 }, "to" : { "x" : 292, "y" : 1950 } } ], "endShape" : { "a" : { "x" : 284, "y" : 1951 }, "b" : { "x" : 292, "y" : 1950 }, "c" : { "x" : 287, "y" : 1944 }, "type" : "ARROW", "centre" : { "x" : 287, "y" : 1944 } }, "reactionShape" : { "c" : { "x" : 269, "y" : 1940 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 269, "y" : 1940 } }, "inputs" : [ { "id" : 133072, "points" : [ { "x" : 228, "y" : 1954 } ] }, { "id" : 133073, "points" : [ { "x" : 233, "y" : 1933 } ] } ], "outputs" : [ { "id" : 133074 } ] }, { "id" : 132818, "reactomeId" : 10360202, "displayName" : "Cholecystokinin receptors bind cholecystokinin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1461, "y" : 547 }, "minX" : 1439, "maxX" : 1487, "minY" : 541, "maxY" : 563, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1439, "y" : 547 }, "to" : { "x" : 1461, "y" : 547 } }, { "from" : { "x" : 1461, "y" : 547 }, "to" : { "x" : 1487, "y" : 563 } } ], "endShape" : { "a" : { "x" : 1479, "y" : 563 }, "b" : { "x" : 1487, "y" : 563 }, "c" : { "x" : 1483, "y" : 556 }, "type" : "ARROW", "centre" : { "x" : 1483, "y" : 556 } }, "reactionShape" : { "c" : { "x" : 1461, "y" : 547 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1461, "y" : 547 } }, "inputs" : [ { "id" : 132819, "points" : [ { "x" : 1419, "y" : 560 } ] }, { "id" : 132820, "points" : [ { "x" : 1417, "y" : 535 } ] } ], "outputs" : [ { "id" : 132821 } ] }, { "id" : 133075, "reactomeId" : 10362427, "displayName" : "LPA-binding receptors bind LPA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2081, "y" : 1932 }, "minX" : 2057, "maxX" : 2137, "minY" : 1926, "maxY" : 1956, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2057, "y" : 1932 }, "to" : { "x" : 2081, "y" : 1932 } }, { "from" : { "x" : 2081, "y" : 1932 }, "to" : { "x" : 2137, "y" : 1956 } } ], "endShape" : { "a" : { "x" : 2129, "y" : 1957 }, "b" : { "x" : 2137, "y" : 1956 }, "c" : { "x" : 2132, "y" : 1950 }, "type" : "ARROW", "centre" : { "x" : 2132, "y" : 1950 } }, "reactionShape" : { "c" : { "x" : 2081, "y" : 1932 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2081, "y" : 1932 } }, "inputs" : [ { "id" : 133076, "points" : [ { "x" : 2029, "y" : 1954 } ] }, { "id" : 133077, "points" : [ { "x" : 2022, "y" : 1924 } ] } ], "outputs" : [ { "id" : 133078 } ] }, { "id" : 132822, "reactomeId" : 10360204, "displayName" : "EDNRA,EDNRB bind EDNs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1961, "y" : 2439 }, "minX" : 1938, "maxX" : 1979, "minY" : 2417, "maxY" : 2456, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1944, "y" : 2423 }, "to" : { "x" : 1961, "y" : 2439 } }, { "from" : { "x" : 1961, "y" : 2439 }, "to" : { "x" : 1979, "y" : 2456 } } ], "endShape" : { "a" : { "x" : 1971, "y" : 2454 }, "b" : { "x" : 1979, "y" : 2456 }, "c" : { "x" : 1977, "y" : 2448 }, "type" : "ARROW", "centre" : { "x" : 1977, "y" : 2448 } }, "reactionShape" : { "c" : { "x" : 1961, "y" : 2439 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1961, "y" : 2439 } }, "inputs" : [ { "id" : 132823, "points" : [ { "x" : 1944, "y" : 2390 } ] }, { "id" : 132824, "points" : [ { "x" : 1920, "y" : 2459 } ] } ], "outputs" : [ { "id" : 132825 } ] }, { "id" : 133079, "reactomeId" : 10362431, "displayName" : "S1PR2-5 bind S1P", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 625, "y" : 1933 }, "minX" : 603, "maxX" : 657, "minY" : 1927, "maxY" : 1956, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 603, "y" : 1933 }, "to" : { "x" : 625, "y" : 1933 } }, { "from" : { "x" : 625, "y" : 1933 }, "to" : { "x" : 657, "y" : 1956 } } ], "endShape" : { "a" : { "x" : 649, "y" : 1955 }, "b" : { "x" : 657, "y" : 1956 }, "c" : { "x" : 654, "y" : 1949 }, "type" : "ARROW", "centre" : { "x" : 654, "y" : 1949 } }, "reactionShape" : { "c" : { "x" : 625, "y" : 1933 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 625, "y" : 1933 } }, "inputs" : [ { "id" : 133080, "points" : [ { "x" : 583, "y" : 1925 } ] }, { "id" : 133081, "points" : [ { "x" : 572, "y" : 1957 } ] } ], "outputs" : [ { "id" : 133082 } ] }, { "id" : 132826, "reactomeId" : 10360206, "displayName" : "Melanocortin receptors bind melanocortins", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 240, "y" : 947 }, "minX" : 208, "maxX" : 276, "minY" : 931, "maxY" : 953, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 208, "y" : 946 }, "to" : { "x" : 240, "y" : 947 } }, { "from" : { "x" : 240, "y" : 947 }, "to" : { "x" : 276, "y" : 931 } } ], "endShape" : { "a" : { "x" : 271, "y" : 937 }, "b" : { "x" : 276, "y" : 931 }, "c" : { "x" : 268, "y" : 930 }, "type" : "ARROW", "centre" : { "x" : 268, "y" : 930 } }, "reactionShape" : { "c" : { "x" : 240, "y" : 947 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 240, "y" : 947 } }, "inputs" : [ { "id" : 132827, "points" : [ { "x" : 202, "y" : 929 } ] }, { "id" : 132828, "points" : [ { "x" : 192, "y" : 953 } ] } ], "outputs" : [ { "id" : 132829 } ] }, { "id" : 133083, "reactomeId" : 10362482, "displayName" : "Light stimulates opsin receptors", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2564, "y" : 1972 }, "minX" : 2532, "maxX" : 2585, "minY" : 1966, "maxY" : 1995, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2532, "y" : 1971 }, "to" : { "x" : 2564, "y" : 1972 } }, { "from" : { "x" : 2564, "y" : 1972 }, "to" : { "x" : 2585, "y" : 1995 } } ], "endShape" : { "a" : { "x" : 2577, "y" : 1993 }, "b" : { "x" : 2585, "y" : 1995 }, "c" : { "x" : 2583, "y" : 1987 }, "type" : "ARROW", "centre" : { "x" : 2583, "y" : 1987 } }, "reactionShape" : { "c" : { "x" : 2564, "y" : 1972 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2564, "y" : 1972 } }, "inputs" : [ { "id" : 133084, "points" : [ { "x" : 2533, "y" : 1909 } ] }, { "id" : 133085, "points" : [ { "x" : 2508, "y" : 1992 } ] } ], "outputs" : [ { "id" : 133086 } ] }, { "id" : 132830, "reactomeId" : 10360208, "displayName" : "POMC(138-176) binds MC2R", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 225, "y" : 547 }, "minX" : 204, "maxX" : 247, "minY" : 541, "maxY" : 557, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 204, "y" : 547 }, "to" : { "x" : 225, "y" : 547 } }, { "from" : { "x" : 225, "y" : 547 }, "to" : { "x" : 247, "y" : 557 } } ], "endShape" : { "a" : { "x" : 239, "y" : 558 }, "b" : { "x" : 247, "y" : 557 }, "c" : { "x" : 242, "y" : 550 }, "type" : "ARROW", "centre" : { "x" : 242, "y" : 550 } }, "reactionShape" : { "c" : { "x" : 225, "y" : 547 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 225, "y" : 547 } }, "inputs" : [ { "id" : 132831, "points" : [ { "x" : 194, "y" : 564 } ] }, { "id" : 132832, "points" : [ { "x" : 201, "y" : 535 } ] } ], "outputs" : [ { "id" : 132833 } ] }, { "id" : 133087, "reactomeId" : 10362486, "displayName" : "Melanospin is stimulated by light", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2725, "y" : 1971 }, "minX" : 2693, "maxX" : 2759, "minY" : 1965, "maxY" : 1994, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2693, "y" : 1971 }, "to" : { "x" : 2725, "y" : 1971 } }, { "from" : { "x" : 2725, "y" : 1971 }, "to" : { "x" : 2759, "y" : 1994 } } ], "endShape" : { "a" : { "x" : 2751, "y" : 1993 }, "b" : { "x" : 2759, "y" : 1994 }, "c" : { "x" : 2756, "y" : 1987 }, "type" : "ARROW", "centre" : { "x" : 2756, "y" : 1987 } }, "reactionShape" : { "c" : { "x" : 2725, "y" : 1971 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2725, "y" : 1971 } }, "inputs" : [ { "id" : 133084, "points" : [ { "x" : 2566, "y" : 1905 } ] }, { "id" : 133088, "points" : [ { "x" : 2693, "y" : 1998 } ] } ], "outputs" : [ { "id" : 133089 } ] }, { "id" : 133090, "reactomeId" : 10365125, "displayName" : "Receptor FFAR1 binds free fatty acids", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2925, "y" : 1925 }, "minX" : 2899, "maxX" : 2957, "minY" : 1919, "maxY" : 1945, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2899, "y" : 1927 }, "to" : { "x" : 2925, "y" : 1925 } }, { "from" : { "x" : 2925, "y" : 1925 }, "to" : { "x" : 2957, "y" : 1945 } } ], "endShape" : { "a" : { "x" : 2949, "y" : 1945 }, "b" : { "x" : 2957, "y" : 1945 }, "c" : { "x" : 2953, "y" : 1938 }, "type" : "ARROW", "centre" : { "x" : 2953, "y" : 1938 } }, "reactionShape" : { "c" : { "x" : 2925, "y" : 1925 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2925, "y" : 1925 } }, "inputs" : [ { "id" : 133091, "points" : [ { "x" : 2885, "y" : 1917 } ] }, { "id" : 133092, "points" : [ { "x" : 2885, "y" : 1945 } ] } ], "outputs" : [ { "id" : 133093 } ] }, { "id" : 132834, "reactomeId" : 10360395, "displayName" : "Prolactin-releasing hormone receptor binds PRH", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3683, "y" : 548 }, "minX" : 3661, "maxX" : 3705, "minY" : 542, "maxY" : 557, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3661, "y" : 548 }, "to" : { "x" : 3683, "y" : 548 } }, { "from" : { "x" : 3683, "y" : 548 }, "to" : { "x" : 3705, "y" : 557 } } ], "endShape" : { "a" : { "x" : 3697, "y" : 558 }, "b" : { "x" : 3705, "y" : 557 }, "c" : { "x" : 3700, "y" : 551 }, "type" : "ARROW", "centre" : { "x" : 3700, "y" : 551 } }, "reactionShape" : { "c" : { "x" : 3683, "y" : 548 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3683, "y" : 548 } }, "inputs" : [ { "id" : 132835, "points" : [ { "x" : 3640, "y" : 531 } ] }, { "id" : 132836, "points" : [ { "x" : 3643, "y" : 561 } ] } ], "outputs" : [ { "id" : 132837 } ] }, { "id" : 133094, "reactomeId" : 10365123, "displayName" : "Receptor FFAR2 binds carboxylates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3167, "y" : 1931 }, "minX" : 3145, "maxX" : 3193, "minY" : 1925, "maxY" : 1941, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3145, "y" : 1931 }, "to" : { "x" : 3167, "y" : 1931 } }, { "from" : { "x" : 3167, "y" : 1931 }, "to" : { "x" : 3193, "y" : 1941 } } ], "endShape" : { "a" : { "x" : 3185, "y" : 1942 }, "b" : { "x" : 3193, "y" : 1941 }, "c" : { "x" : 3188, "y" : 1935 }, "type" : "ARROW", "centre" : { "x" : 3188, "y" : 1935 } }, "reactionShape" : { "c" : { "x" : 3167, "y" : 1931 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3167, "y" : 1931 } }, "inputs" : [ { "id" : 133095, "points" : [ { "x" : 3118, "y" : 1946 } ] }, { "id" : 133096, "points" : [ { "x" : 3122, "y" : 1923 } ] } ], "outputs" : [ { "id" : 133097 } ] }, { "id" : 132838, "reactomeId" : 10360397, "displayName" : "Neuropeptide Y receptors can bind neuropeptide Y-related peptides", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3926, "y" : 540 }, "minX" : 3903, "maxX" : 3953, "minY" : 534, "maxY" : 555, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3903, "y" : 540 }, "to" : { "x" : 3926, "y" : 540 } }, { "from" : { "x" : 3926, "y" : 540 }, "to" : { "x" : 3953, "y" : 555 } } ], "endShape" : { "a" : { "x" : 3945, "y" : 555 }, "b" : { "x" : 3953, "y" : 555 }, "c" : { "x" : 3949, "y" : 548 }, "type" : "ARROW", "centre" : { "x" : 3949, "y" : 548 } }, "reactionShape" : { "c" : { "x" : 3926, "y" : 540 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3926, "y" : 540 } }, "inputs" : [ { "id" : 132839, "points" : [ { "x" : 3875, "y" : 551 } ] }, { "id" : 132840, "points" : [ { "x" : 3876, "y" : 530 } ] } ], "outputs" : [ { "id" : 132841 } ] }, { "id" : 133098, "reactomeId" : 10365092, "displayName" : "Receptor FFAR3 binds carboxylates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3417, "y" : 1924 }, "minX" : 3397, "maxX" : 3449, "minY" : 1918, "maxY" : 1940, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3397, "y" : 1925 }, "to" : { "x" : 3417, "y" : 1924 } }, { "from" : { "x" : 3417, "y" : 1924 }, "to" : { "x" : 3449, "y" : 1940 } } ], "endShape" : { "a" : { "x" : 3441, "y" : 1940 }, "b" : { "x" : 3449, "y" : 1940 }, "c" : { "x" : 3445, "y" : 1933 }, "type" : "ARROW", "centre" : { "x" : 3445, "y" : 1933 } }, "reactionShape" : { "c" : { "x" : 3417, "y" : 1924 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3417, "y" : 1924 } }, "inputs" : [ { "id" : 133099, "points" : [ { "x" : 3379, "y" : 1916 } ] }, { "id" : 133100, "points" : [ { "x" : 3356, "y" : 1949 } ] } ], "outputs" : [ { "id" : 133101 } ] }, { "id" : 132842, "reactomeId" : 10360399, "displayName" : "Neurotensin receptors can bind neurotensins", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1687, "y" : 543 }, "minX" : 1665, "maxX" : 1721, "minY" : 537, "maxY" : 560, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1665, "y" : 543 }, "to" : { "x" : 1687, "y" : 543 } }, { "from" : { "x" : 1687, "y" : 543 }, "to" : { "x" : 1721, "y" : 560 } } ], "endShape" : { "a" : { "x" : 1713, "y" : 560 }, "b" : { "x" : 1721, "y" : 560 }, "c" : { "x" : 1717, "y" : 553 }, "type" : "ARROW", "centre" : { "x" : 1717, "y" : 553 } }, "reactionShape" : { "c" : { "x" : 1687, "y" : 543 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1687, "y" : 543 } }, "inputs" : [ { "id" : 132843, "points" : [ { "x" : 1637, "y" : 562 } ] }, { "id" : 132844, "points" : [ { "x" : 1638, "y" : 528 } ] } ], "outputs" : [ { "id" : 132845 } ] }, { "id" : 133102, "reactomeId" : 10365195, "displayName" : "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2761, "y" : 2267 }, "minX" : 2740, "maxX" : 2789, "minY" : 2253, "maxY" : 2273, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2740, "y" : 2269 }, "to" : { "x" : 2761, "y" : 2267 } }, { "from" : { "x" : 2761, "y" : 2267 }, "to" : { "x" : 2789, "y" : 2253 } } ], "endShape" : { "a" : { "x" : 2785, "y" : 2260 }, "b" : { "x" : 2789, "y" : 2253 }, "c" : { "x" : 2781, "y" : 2253 }, "type" : "ARROW", "centre" : { "x" : 2781, "y" : 2253 } }, "reactionShape" : { "c" : { "x" : 2761, "y" : 2267 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2761, "y" : 2267 } }, "inputs" : [ { "id" : 133103, "points" : [ { "x" : 2721, "y" : 2275 } ] }, { "id" : 133104, "points" : [ { "x" : 2722, "y" : 2253 } ] } ], "outputs" : [ { "id" : 133105 } ] }, { "id" : 132846, "reactomeId" : 10360403, "displayName" : "Galanin receptors can bind galanin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3495, "y" : 546 }, "minX" : 3476, "maxX" : 3525, "minY" : 540, "maxY" : 564, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3476, "y" : 545 }, "to" : { "x" : 3495, "y" : 546 } }, { "from" : { "x" : 3495, "y" : 546 }, "to" : { "x" : 3525, "y" : 564 } } ], "endShape" : { "a" : { "x" : 3517, "y" : 564 }, "b" : { "x" : 3525, "y" : 564 }, "c" : { "x" : 3521, "y" : 557 }, "type" : "ARROW", "centre" : { "x" : 3521, "y" : 557 } }, "reactionShape" : { "c" : { "x" : 3495, "y" : 546 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3495, "y" : 546 } }, "inputs" : [ { "id" : 132847, "points" : [ { "x" : 3449, "y" : 529 } ] }, { "id" : 132848, "points" : [ { "x" : 3450, "y" : 557 } ] } ], "outputs" : [ { "id" : 132849 } ] }, { "id" : 133106, "reactomeId" : 10365189, "displayName" : "HCAR2 binds HCAR2 ligands", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 899, "y" : 1930 }, "minX" : 869, "maxX" : 931, "minY" : 1924, "maxY" : 1948, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 869, "y" : 1929 }, "to" : { "x" : 899, "y" : 1930 } }, { "from" : { "x" : 899, "y" : 1930 }, "to" : { "x" : 931, "y" : 1948 } } ], "endShape" : { "a" : { "x" : 923, "y" : 1948 }, "b" : { "x" : 931, "y" : 1948 }, "c" : { "x" : 927, "y" : 1941 }, "type" : "ARROW", "centre" : { "x" : 927, "y" : 1941 } }, "reactionShape" : { "c" : { "x" : 899, "y" : 1930 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 899, "y" : 1930 } }, "inputs" : [ { "id" : 133107, "points" : [ { "x" : 833, "y" : 1956 } ] }, { "id" : 133108, "points" : [ { "x" : 843, "y" : 1920 } ] } ], "outputs" : [ { "id" : 133109 } ] }, { "id" : 132850, "reactomeId" : 10360401, "displayName" : "The Kiss receptor GPR54 binds kisspeptin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2606, "y" : 552 }, "minX" : 2587, "maxX" : 2627, "minY" : 546, "maxY" : 561, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2587, "y" : 553 }, "to" : { "x" : 2606, "y" : 552 } }, { "from" : { "x" : 2606, "y" : 552 }, "to" : { "x" : 2627, "y" : 561 } } ], "endShape" : { "a" : { "x" : 2619, "y" : 562 }, "b" : { "x" : 2627, "y" : 561 }, "c" : { "x" : 2622, "y" : 555 }, "type" : "ARROW", "centre" : { "x" : 2622, "y" : 555 } }, "reactionShape" : { "c" : { "x" : 2606, "y" : 552 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2606, "y" : 552 } }, "inputs" : [ { "id" : 132851, "points" : [ { "x" : 2564, "y" : 563 } ] }, { "id" : 132852, "points" : [ { "x" : 2571, "y" : 545 } ] } ], "outputs" : [ { "id" : 132853 } ] }, { "id" : 132854, "reactomeId" : 10360458, "displayName" : "Proteinase-activated receptors can bind thrombin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2821, "y" : 543 }, "minX" : 2806, "maxX" : 2845, "minY" : 537, "maxY" : 558, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2806, "y" : 543 }, "to" : { "x" : 2821, "y" : 543 } }, { "from" : { "x" : 2821, "y" : 543 }, "to" : { "x" : 2845, "y" : 558 } } ], "endShape" : { "a" : { "x" : 2837, "y" : 558 }, "b" : { "x" : 2845, "y" : 558 }, "c" : { "x" : 2841, "y" : 551 }, "type" : "ARROW", "centre" : { "x" : 2841, "y" : 551 } }, "reactionShape" : { "c" : { "x" : 2821, "y" : 543 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2821, "y" : 543 } }, "inputs" : [ { "id" : 132855, "points" : [ { "x" : 2800, "y" : 536 } ] }, { "id" : 132856, "points" : [ { "x" : 2793, "y" : 548 } ] } ], "outputs" : [ { "id" : 132857 } ] }, { "id" : 133110, "reactomeId" : 10365187, "displayName" : "G-protein coupled bile acid receptor binds lithocholic acid", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2393, "y" : 1088 }, "minX" : 2372, "maxX" : 2414, "minY" : 1082, "maxY" : 1103, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2372, "y" : 1088 }, "to" : { "x" : 2393, "y" : 1088 } }, { "from" : { "x" : 2393, "y" : 1088 }, "to" : { "x" : 2414, "y" : 1103 } } ], "endShape" : { "a" : { "x" : 2406, "y" : 1102 }, "b" : { "x" : 2414, "y" : 1103 }, "c" : { "x" : 2411, "y" : 1096 }, "type" : "ARROW", "centre" : { "x" : 2411, "y" : 1096 } }, "reactionShape" : { "c" : { "x" : 2393, "y" : 1088 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2393, "y" : 1088 } }, "inputs" : [ { "id" : 133111, "points" : [ { "x" : 2365, "y" : 1082 } ] }, { "id" : 133112, "points" : [ { "x" : 2349, "y" : 1099 } ] } ], "outputs" : [ { "id" : 133113 } ] }, { "id" : 132858, "reactomeId" : 10360460, "displayName" : "Orexin 1 receptor can bind orexin-A neuropeptide", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3042, "y" : 556 }, "minX" : 3021, "maxX" : 3065, "minY" : 550, "maxY" : 562, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3021, "y" : 558 }, "to" : { "x" : 3042, "y" : 556 } }, { "from" : { "x" : 3042, "y" : 556 }, "to" : { "x" : 3065, "y" : 562 } } ], "endShape" : { "a" : { "x" : 3057, "y" : 564 }, "b" : { "x" : 3065, "y" : 562 }, "c" : { "x" : 3059, "y" : 556 }, "type" : "ARROW", "centre" : { "x" : 3059, "y" : 556 } }, "reactionShape" : { "c" : { "x" : 3042, "y" : 556 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3042, "y" : 556 } }, "inputs" : [ { "id" : 132859, "points" : [ { "x" : 3009, "y" : 549 } ] }, { "id" : 132860, "points" : [ { "x" : 3002, "y" : 565 } ] } ], "outputs" : [ { "id" : 132861 } ] }, { "id" : 133114, "reactomeId" : 10365179, "displayName" : "Zinc is an agonist of GPR39", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3173, "y" : 2248 }, "minX" : 3155, "maxX" : 3197, "minY" : 2238, "maxY" : 2254, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3155, "y" : 2248 }, "to" : { "x" : 3173, "y" : 2248 } }, { "from" : { "x" : 3173, "y" : 2248 }, "to" : { "x" : 3197, "y" : 2238 } } ], "endShape" : { "a" : { "x" : 3192, "y" : 2244 }, "b" : { "x" : 3197, "y" : 2238 }, "c" : { "x" : 3189, "y" : 2237 }, "type" : "ARROW", "centre" : { "x" : 3189, "y" : 2237 } }, "reactionShape" : { "c" : { "x" : 3173, "y" : 2248 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3173, "y" : 2248 } }, "inputs" : [ { "id" : 133115, "points" : [ { "x" : 3136, "y" : 2258 } ] }, { "id" : 133116, "points" : [ { "x" : 3141, "y" : 2241 } ] } ], "outputs" : [ { "id" : 133117 } ] }, { "id" : 132862, "reactomeId" : 10360462, "displayName" : "Orexin 2 receptor can bind orexin-B neuropeptide", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3275, "y" : 549 }, "minX" : 3259, "maxX" : 3296, "minY" : 543, "maxY" : 556, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3259, "y" : 550 }, "to" : { "x" : 3275, "y" : 549 } }, { "from" : { "x" : 3275, "y" : 549 }, "to" : { "x" : 3296, "y" : 556 } } ], "endShape" : { "a" : { "x" : 3288, "y" : 558 }, "b" : { "x" : 3296, "y" : 556 }, "c" : { "x" : 3291, "y" : 550 }, "type" : "ARROW", "centre" : { "x" : 3291, "y" : 550 } }, "reactionShape" : { "c" : { "x" : 3275, "y" : 549 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3275, "y" : 549 } }, "inputs" : [ { "id" : 132863, "points" : [ { "x" : 3238, "y" : 563 } ] }, { "id" : 132864, "points" : [ { "x" : 3240, "y" : 538 } ] } ], "outputs" : [ { "id" : 132865 } ] }, { "id" : 133118, "reactomeId" : 10367976, "displayName" : "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 674, "y" : 2255 }, "minX" : 647, "maxX" : 699, "minY" : 2249, "maxY" : 2261, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 647, "y" : 2256 }, "to" : { "x" : 674, "y" : 2255 } }, { "from" : { "x" : 674, "y" : 2255 }, "to" : { "x" : 699, "y" : 2250 } } ], "endShape" : { "a" : { "x" : 693, "y" : 2255 }, "b" : { "x" : 699, "y" : 2250 }, "c" : { "x" : 691, "y" : 2247 }, "type" : "ARROW", "centre" : { "x" : 691, "y" : 2247 } }, "reactionShape" : { "c" : { "x" : 674, "y" : 2255 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 674, "y" : 2255 } }, "inputs" : [ { "id" : 133119, "points" : [ { "x" : 628, "y" : 2265 } ] }, { "id" : 133120, "points" : [ { "x" : 631, "y" : 2250 } ] } ], "outputs" : [ { "id" : 133121 } ] } ], "compartments" : [ { "id" : 133347, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2091, "y" : 1365 }, "minX" : 145, "maxX" : 4038, "minY" : 1112, "maxY" : 1619, "prop" : { "x" : 145, "y" : 1112, "width" : 3893, "height" : 507 }, "textPosition" : { "x" : 178, "y" : 1520 }, "insets" : { "x" : 155, "y" : 1122, "width" : 3873, "height" : 487 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 132987, 132988, 132927, 132929, 132931, 132932, 132942, 132944, 132946, 132947, 132949, 132950, 132952, 132954, 132957, 132958, 132965, 132966, 132968, 132970, 132973, 132976, 132977, 132979, 132980, 133112, 133348, 133443, 133349, 133444, 133350, 133445, 133446, 133447, 133448, 133450, 133452, 133453, 133455, 133456, 133457, 133458, 133460, 133461, 133462, 133463, 133464, 133465, 133466, 133467, 133468, 133469, 133470, 133471, 133473, 133474, 133475, 133476, 133477, 133478, 132995, 132996, 132998, 132999, 133009, 133011, 133014, 133015, 133018, 133019, 133022, 133023, 133026, 133029, 133031, 133037, 133039, 133041, 133053, 133055, 133058, 133059, 133061, 133062, 133002, 133003, 132991, 132992, 133351, 133459, 133043, 133045, 133047, 133048, 133050, 133051, 133033, 133035, 133113, 132974, 133451, 133454, 133472, 133027, 132922, 132924, 132925, 133212, 133219, 132923, 133223, 133226, 133225, 133508, 133509, 133227, 133025, 133440, 133222, 132921, 133241, 133243, 133244, 133246, 133245, 133534 ] }, { "id" : 133345, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2095, "y" : 745 }, "minX" : 140, "maxX" : 4051, "minY" : 575, "maxY" : 915, "prop" : { "x" : 140, "y" : 575, "width" : 3911, "height" : 340 }, "textPosition" : { "x" : 188, "y" : 834 }, "insets" : { "x" : 150, "y" : 585, "width" : 3891, "height" : 320 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 132839, 132841, 132780, 132781, 132803, 132805, 132815, 132817, 132819, 132821, 132827, 132829, 132831, 132833, 132836, 132837, 132843, 132845, 132848, 132849, 132851, 132853, 132856, 132857, 132860, 132861, 132863, 132865, 132867, 132869, 132871, 132873, 132875, 132877, 132879, 132881, 132884, 132885, 132888, 132889, 132892, 132893, 132895, 132897, 132900, 132901, 132911, 132913, 132917, 132918, 133173, 133174, 133198, 133336, 133342, 133343, 133412, 133413, 133414, 133415, 133344, 133416, 133417, 133418, 133419, 133420, 133421, 133422, 133423, 133424, 133425, 133426, 133427, 133428, 133429, 133430, 133431, 133432, 133433, 133434, 133435, 133436, 133437, 133438, 133439, 133441, 133346, 133442, 132915, 132914, 133240 ] }, { "id" : 133338, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2088, "y" : 226 }, "minX" : 142, "maxX" : 4035, "minY" : 82, "maxY" : 370, "prop" : { "x" : 142, "y" : 82, "width" : 3893, "height" : 288 }, "textPosition" : { "x" : 247, "y" : 297 }, "insets" : { "x" : 152, "y" : 92, "width" : 3873, "height" : 268 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 132721, 132724, 132725, 132692, 132695, 132697, 132699, 132701, 132704, 132705, 132708, 132709, 132712, 132713, 132716, 132717, 132720, 133373, 133374, 132728, 132729, 132732, 132736, 132737, 132740, 132741, 132745, 132749, 132751, 132753, 132755, 132757, 132759, 132761, 132765, 132767, 132769, 132771, 132773, 132775, 132777, 132784, 132785, 132788, 132789, 132792, 132793, 132796, 132800, 132801, 132743, 132747, 132763, 133160, 133161, 133177, 133178, 133180, 133182, 133339, 133381, 133340, 133382, 133383, 133384, 133385, 133386, 133387, 133388, 133389, 133390, 133391, 133392, 133393, 133394, 133395, 133396, 133397, 133398, 133399, 133400, 133401, 133402, 133403, 133404, 133405, 133406, 132797, 133407, 133408, 133409, 133410, 133411, 132733, 132693, 132798, 132691, 133217, 133216, 133510, 133511, 133379 ] }, { "id" : 133336, "reactomeId" : 1462052, "displayName" : "secretory granule lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 896, "y" : 669 }, "minX" : 783, "maxX" : 1010, "minY" : 620, "maxY" : 718, "prop" : { "x" : 783, "y" : 620, "width" : 227, "height" : 98 }, "textPosition" : { "x" : 821, "y" : 673 }, "insets" : { "x" : 793, "y" : 630, "width" : 207, "height" : 78 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 133199, 133200, 133201, 133202 ] }, { "id" : 133352, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2089, "y" : 2101 }, "minX" : 144, "maxX" : 4034, "minY" : 1965, "maxY" : 2237, "prop" : { "x" : 144, "y" : 1965, "width" : 3890, "height" : 272 }, "textPosition" : { "x" : 166, "y" : 2108 }, "insets" : { "x" : 154, "y" : 1975, "width" : 3870, "height" : 252 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 133072, 133074, 133081, 133082, 133068, 133070, 133092, 133093, 133095, 133097, 133100, 133101, 133329, 133104, 133105, 133332, 133127, 133132, 133165, 133337, 133206, 133116, 133117, 133120, 133121, 133129, 133133, 133135, 133137, 133148, 133149, 133152, 133153, 133155, 133157, 133164, 133209, 133188, 133190, 133205, 133353, 133479, 133354, 133480, 133482, 133083, 133484, 133487, 133488, 133492, 133493, 133485, 133486, 133087, 133107, 133109, 133140, 133141, 133143, 133145, 133184, 133186, 133076, 133078, 133494, 133495, 133496, 133497, 133498, 133499, 133500, 133501, 133502, 133503, 133355, 133504, 133505, 133506, 133507, 133489, 133490, 133491, 133208, 133483, 133481 ] }, { "id" : 133337, "reactomeId" : 2514888, "displayName" : "photoreceptor disc membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2668, "y" : 2042 }, "minX" : 2471, "maxX" : 2866, "minY" : 2018, "maxY" : 2066, "prop" : { "x" : 2471, "y" : 2018, "width" : 395, "height" : 48 }, "textPosition" : { "x" : 2515, "y" : 2030 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 133085, 133086, 133088, 133089 ] }, { "id" : 133356, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2098, "y" : 2591 }, "minX" : 158, "maxX" : 4039, "minY" : 2475, "maxY" : 2707, "prop" : { "x" : 158, "y" : 2475, "width" : 3881, "height" : 232 }, "textPosition" : { "x" : 432, "y" : 2518 }, "insets" : { "x" : 168, "y" : 2485, "width" : 3861, "height" : 212 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 132812, 132813, 132809, 132807, 133341, 133357, 133512, 133249, 133251, 133252, 133254, 133513, 133514, 133255, 133515, 133259, 133257, 133517, 133005, 133007, 133004, 133516, 133260, 133262, 133518, 133519, 133261, 133263, 133358, 133267, 133269, 133520, 133270, 132934, 132936, 132940, 133275, 133521, 132938, 133277, 133278, 133281, 133285, 133283, 133522, 133288, 133523, 133524, 133291, 133282, 133064, 133066, 133527, 133294, 133528, 132909, 132908, 133529, 132903, 132905, 133530, 133297, 133526, 133301, 133300, 133531, 132984, 132983, 133533, 133304, 132961, 132962, 133449, 133307, 133310, 133313, 133535, 132825, 132824, 133536, 133316, 133318, 133319, 133322 ] } ], "notes" : [ ], "links" : [ { "id" : 133378, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 2206, "y" : 372 }, "minX" : 2146, "maxX" : 2266, "minY" : 366, "maxY" : 378, "segments" : [ { "from" : { "x" : 2146, "y" : 372 }, "to" : { "x" : 2266, "y" : 372 } } ], "reactionShape" : { "a" : { "x" : 2200, "y" : 366 }, "b" : { "x" : 2212, "y" : 378 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2206, "y" : 372 } }, "inputs" : [ { "id" : 133180 } ], "outputs" : [ { "id" : 132771 } ] }, { "id" : 133379, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 2411, "y" : 369 }, "minX" : 2146, "maxX" : 2677, "minY" : 363, "maxY" : 375, "segments" : [ { "from" : { "x" : 2146, "y" : 371 }, "to" : { "x" : 2677, "y" : 368 } } ], "reactionShape" : { "a" : { "x" : 2405, "y" : 363 }, "b" : { "x" : 2417, "y" : 375 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2411, "y" : 369 } }, "inputs" : [ { "id" : 133180 } ], "outputs" : [ { "id" : 132775 } ] }, { "id" : 133376, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1427, "y" : 1454 }, "minX" : 918, "maxX" : 1937, "minY" : 554, "maxY" : 2355, "segments" : [ { "from" : { "x" : 918, "y" : 554 }, "to" : { "x" : 1937, "y" : 2355 } } ], "reactionShape" : { "a" : { "x" : 1421, "y" : 1448 }, "b" : { "x" : 1433, "y" : 1460 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1427, "y" : 1454 } }, "inputs" : [ { "id" : 133334 } ], "outputs" : [ { "id" : 132823 } ] }, { "id" : 133377, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 2415, "y" : 372 }, "minX" : 2348, "maxX" : 2482, "minY" : 366, "maxY" : 378, "segments" : [ { "from" : { "x" : 2482, "y" : 372 }, "to" : { "x" : 2348, "y" : 372 } } ], "reactionShape" : { "a" : { "x" : 2409, "y" : 366 }, "b" : { "x" : 2421, "y" : 378 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2415, "y" : 372 } }, "inputs" : [ { "id" : 133177 } ], "outputs" : [ { "id" : 132771 } ] }, { "id" : 133382, "renderableClass" : "Interaction", "position" : { "x" : 644, "y" : 152 }, "minX" : 546, "maxX" : 743, "minY" : 108, "maxY" : 197, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 546, "y" : 108 }, "to" : { "x" : 743, "y" : 197 } } ], "endShape" : { "a" : { "x" : 735, "y" : 198 }, "b" : { "x" : 743, "y" : 197 }, "c" : { "x" : 738, "y" : 191 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 738, "y" : 191 } }, "reactionShape" : { "a" : { "x" : 638, "y" : 146 }, "b" : { "x" : 650, "y" : 158 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 644, "y" : 152 } }, "inputs" : [ { "id" : 132692 } ], "outputs" : [ { "id" : 133340 } ] }, { "id" : 133383, "renderableClass" : "Interaction", "position" : { "x" : 3326, "y" : 150 }, "minX" : 2677, "maxX" : 3368, "minY" : 109, "maxY" : 206, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3368, "y" : 109 }, "to" : { "x" : 3326, "y" : 150 } }, { "from" : { "x" : 3326, "y" : 150 }, "to" : { "x" : 2677, "y" : 206 } } ], "endShape" : { "a" : { "x" : 2684, "y" : 201 }, "b" : { "x" : 2677, "y" : 206 }, "c" : { "x" : 2684, "y" : 209 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2684, "y" : 209 } }, "reactionShape" : { "a" : { "x" : 3320, "y" : 144 }, "b" : { "x" : 3332, "y" : 156 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3326, "y" : 150 } }, "inputs" : [ { "id" : 132697 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133380, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1472, "y" : 1454 }, "minX" : 1006, "maxX" : 1938, "minY" : 554, "maxY" : 2355, "segments" : [ { "from" : { "x" : 1006, "y" : 554 }, "to" : { "x" : 1938, "y" : 2355 } } ], "reactionShape" : { "a" : { "x" : 1466, "y" : 1448 }, "b" : { "x" : 1478, "y" : 1460 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1472, "y" : 1454 } }, "inputs" : [ { "id" : 133197 } ], "outputs" : [ { "id" : 132823 } ] }, { "id" : 133381, "renderableClass" : "Interaction", "position" : { "x" : 1077, "y" : 230 }, "minX" : 546, "maxX" : 2505, "minY" : 100, "maxY" : 236, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 546, "y" : 100 }, "to" : { "x" : 1077, "y" : 230 } }, { "from" : { "x" : 1077, "y" : 230 }, "to" : { "x" : 2505, "y" : 214 } } ], "endShape" : { "a" : { "x" : 2498, "y" : 218 }, "b" : { "x" : 2505, "y" : 214 }, "c" : { "x" : 2498, "y" : 210 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2498, "y" : 210 } }, "reactionShape" : { "a" : { "x" : 1071, "y" : 224 }, "b" : { "x" : 1083, "y" : 236 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1077, "y" : 230 } }, "inputs" : [ { "id" : 132692 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133386, "renderableClass" : "Interaction", "position" : { "x" : 1348, "y" : 202 }, "minX" : 1261, "maxX" : 2505, "minY" : 113, "maxY" : 213, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1261, "y" : 113 }, "to" : { "x" : 1348, "y" : 202 } }, { "from" : { "x" : 1348, "y" : 202 }, "to" : { "x" : 2505, "y" : 213 } } ], "endShape" : { "a" : { "x" : 2498, "y" : 217 }, "b" : { "x" : 2505, "y" : 213 }, "c" : { "x" : 2498, "y" : 209 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2498, "y" : 209 } }, "reactionShape" : { "a" : { "x" : 1342, "y" : 196 }, "b" : { "x" : 1354, "y" : 208 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1348, "y" : 202 } }, "inputs" : [ { "id" : 132705 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133387, "renderableClass" : "Interaction", "position" : { "x" : 1686, "y" : 182 }, "minX" : 1629, "maxX" : 2505, "minY" : 93, "maxY" : 211, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1629, "y" : 93 }, "to" : { "x" : 1686, "y" : 182 } }, { "from" : { "x" : 1686, "y" : 182 }, "to" : { "x" : 2505, "y" : 211 } } ], "endShape" : { "a" : { "x" : 2498, "y" : 215 }, "b" : { "x" : 2505, "y" : 211 }, "c" : { "x" : 2498, "y" : 207 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2498, "y" : 207 } }, "reactionShape" : { "a" : { "x" : 1680, "y" : 176 }, "b" : { "x" : 1692, "y" : 188 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1686, "y" : 182 } }, "inputs" : [ { "id" : 132709 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133384, "renderableClass" : "Interaction", "position" : { "x" : 893, "y" : 156 }, "minX" : 855, "maxX" : 932, "minY" : 116, "maxY" : 197, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 932, "y" : 116 }, "to" : { "x" : 855, "y" : 197 } } ], "endShape" : { "a" : { "x" : 857, "y" : 189 }, "b" : { "x" : 855, "y" : 197 }, "c" : { "x" : 863, "y" : 195 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 863, "y" : 195 } }, "reactionShape" : { "a" : { "x" : 887, "y" : 150 }, "b" : { "x" : 899, "y" : 162 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 893, "y" : 156 } }, "inputs" : [ { "id" : 132701 } ], "outputs" : [ { "id" : 133340 } ] }, { "id" : 133385, "renderableClass" : "Interaction", "position" : { "x" : 1049, "y" : 153 }, "minX" : 905, "maxX" : 1194, "minY" : 100, "maxY" : 206, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1194, "y" : 100 }, "to" : { "x" : 905, "y" : 206 } } ], "endShape" : { "a" : { "x" : 910, "y" : 200 }, "b" : { "x" : 905, "y" : 206 }, "c" : { "x" : 913, "y" : 207 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 913, "y" : 207 } }, "reactionShape" : { "a" : { "x" : 1043, "y" : 147 }, "b" : { "x" : 1055, "y" : 159 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1049, "y" : 153 } }, "inputs" : [ { "id" : 132705 } ], "outputs" : [ { "id" : 133340 } ] }, { "id" : 133390, "renderableClass" : "Interaction", "position" : { "x" : 2438, "y" : 138 }, "minX" : 2369, "maxX" : 2508, "minY" : 105, "maxY" : 171, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2369, "y" : 105 }, "to" : { "x" : 2508, "y" : 171 } } ], "endShape" : { "a" : { "x" : 2500, "y" : 172 }, "b" : { "x" : 2508, "y" : 171 }, "c" : { "x" : 2503, "y" : 164 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2503, "y" : 164 } }, "reactionShape" : { "a" : { "x" : 2432, "y" : 132 }, "b" : { "x" : 2444, "y" : 144 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2438, "y" : 138 } }, "inputs" : [ { "id" : 132721 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133391, "renderableClass" : "Interaction", "position" : { "x" : 2579, "y" : 140 }, "minX" : 2573, "maxX" : 2585, "minY" : 110, "maxY" : 171, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2575, "y" : 110 }, "to" : { "x" : 2584, "y" : 171 } } ], "endShape" : { "a" : { "x" : 2579, "y" : 165 }, "b" : { "x" : 2584, "y" : 171 }, "c" : { "x" : 2587, "y" : 164 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2587, "y" : 164 } }, "reactionShape" : { "a" : { "x" : 2573, "y" : 134 }, "b" : { "x" : 2585, "y" : 146 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2579, "y" : 140 } }, "inputs" : [ { "id" : 132725 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133388, "renderableClass" : "Interaction", "position" : { "x" : 1908, "y" : 168 }, "minX" : 1846, "maxX" : 2505, "minY" : 99, "maxY" : 208, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1846, "y" : 99 }, "to" : { "x" : 1908, "y" : 168 } }, { "from" : { "x" : 1908, "y" : 168 }, "to" : { "x" : 2505, "y" : 208 } } ], "endShape" : { "a" : { "x" : 2498, "y" : 212 }, "b" : { "x" : 2505, "y" : 208 }, "c" : { "x" : 2498, "y" : 204 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2498, "y" : 204 } }, "reactionShape" : { "a" : { "x" : 1902, "y" : 162 }, "b" : { "x" : 1914, "y" : 174 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1908, "y" : 168 } }, "inputs" : [ { "id" : 132713 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133394, "renderableClass" : "Interaction", "position" : { "x" : 733, "y" : 309 }, "minX" : 690, "maxX" : 776, "minY" : 276, "maxY" : 342, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 690, "y" : 342 }, "to" : { "x" : 776, "y" : 276 } } ], "endShape" : { "a" : { "x" : 773, "y" : 283 }, "b" : { "x" : 776, "y" : 276 }, "c" : { "x" : 768, "y" : 277 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 768, "y" : 277 } }, "reactionShape" : { "a" : { "x" : 727, "y" : 303 }, "b" : { "x" : 739, "y" : 315 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 733, "y" : 309 } }, "inputs" : [ { "id" : 132797 } ], "outputs" : [ { "id" : 133340 } ] }, { "id" : 133395, "renderableClass" : "Interaction", "position" : { "x" : 496, "y" : 199 }, "minX" : 253, "maxX" : 740, "minY" : 172, "maxY" : 227, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 253, "y" : 172 }, "to" : { "x" : 740, "y" : 227 } } ], "endShape" : { "a" : { "x" : 733, "y" : 230 }, "b" : { "x" : 740, "y" : 227 }, "c" : { "x" : 734, "y" : 222 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 734, "y" : 222 } }, "reactionShape" : { "a" : { "x" : 490, "y" : 193 }, "b" : { "x" : 502, "y" : 205 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 496, "y" : 199 } }, "inputs" : [ { "id" : 132801 } ], "outputs" : [ { "id" : 133340 } ] }, { "id" : 133392, "renderableClass" : "Interaction", "position" : { "x" : 2727, "y" : 137 }, "minX" : 2664, "maxX" : 2790, "minY" : 104, "maxY" : 171, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2790, "y" : 104 }, "to" : { "x" : 2664, "y" : 171 } } ], "endShape" : { "a" : { "x" : 2668, "y" : 164 }, "b" : { "x" : 2664, "y" : 171 }, "c" : { "x" : 2672, "y" : 171 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2672, "y" : 171 } }, "reactionShape" : { "a" : { "x" : 2721, "y" : 131 }, "b" : { "x" : 2733, "y" : 143 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2727, "y" : 137 } }, "inputs" : [ { "id" : 132729 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133393, "renderableClass" : "Interaction", "position" : { "x" : 3073, "y" : 150 }, "minX" : 2677, "maxX" : 3100, "minY" : 108, "maxY" : 202, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3100, "y" : 108 }, "to" : { "x" : 3073, "y" : 150 } }, { "from" : { "x" : 3073, "y" : 150 }, "to" : { "x" : 2677, "y" : 202 } } ], "endShape" : { "a" : { "x" : 2683, "y" : 197 }, "b" : { "x" : 2677, "y" : 202 }, "c" : { "x" : 2684, "y" : 205 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2684, "y" : 205 } }, "reactionShape" : { "a" : { "x" : 3067, "y" : 144 }, "b" : { "x" : 3079, "y" : 156 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3073, "y" : 150 } }, "inputs" : [ { "id" : 132793 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133398, "renderableClass" : "Interaction", "position" : { "x" : 861, "y" : 312 }, "minX" : 841, "maxX" : 881, "minY" : 276, "maxY" : 349, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 881, "y" : 349 }, "to" : { "x" : 841, "y" : 276 } } ], "endShape" : { "a" : { "x" : 848, "y" : 280 }, "b" : { "x" : 841, "y" : 276 }, "c" : { "x" : 841, "y" : 284 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 841, "y" : 284 } }, "reactionShape" : { "a" : { "x" : 855, "y" : 306 }, "b" : { "x" : 867, "y" : 318 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 861, "y" : 312 } }, "inputs" : [ { "id" : 132753 } ], "outputs" : [ { "id" : 133340 } ] }, { "id" : 133399, "renderableClass" : "Interaction", "position" : { "x" : 1468, "y" : 260 }, "minX" : 1401, "maxX" : 2505, "minY" : 217, "maxY" : 345, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1401, "y" : 345 }, "to" : { "x" : 1468, "y" : 260 } }, { "from" : { "x" : 1468, "y" : 260 }, "to" : { "x" : 2505, "y" : 217 } } ], "endShape" : { "a" : { "x" : 2498, "y" : 221 }, "b" : { "x" : 2505, "y" : 217 }, "c" : { "x" : 2498, "y" : 213 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2498, "y" : 213 } }, "reactionShape" : { "a" : { "x" : 1462, "y" : 254 }, "b" : { "x" : 1474, "y" : 266 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1468, "y" : 260 } }, "inputs" : [ { "id" : 132761 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133396, "renderableClass" : "Interaction", "position" : { "x" : 3530, "y" : 182 }, "minX" : 2677, "maxX" : 3591, "minY" : 110, "maxY" : 211, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3591, "y" : 110 }, "to" : { "x" : 3530, "y" : 182 } }, { "from" : { "x" : 3530, "y" : 182 }, "to" : { "x" : 2677, "y" : 211 } } ], "endShape" : { "a" : { "x" : 2684, "y" : 207 }, "b" : { "x" : 2677, "y" : 211 }, "c" : { "x" : 2684, "y" : 215 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2684, "y" : 215 } }, "reactionShape" : { "a" : { "x" : 3524, "y" : 176 }, "b" : { "x" : 3536, "y" : 188 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3530, "y" : 182 } }, "inputs" : [ { "id" : 132749 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133397, "renderableClass" : "Interaction", "position" : { "x" : 1009, "y" : 307 }, "minX" : 905, "maxX" : 1113, "minY" : 266, "maxY" : 348, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1113, "y" : 348 }, "to" : { "x" : 905, "y" : 266 } } ], "endShape" : { "a" : { "x" : 913, "y" : 265 }, "b" : { "x" : 905, "y" : 266 }, "c" : { "x" : 910, "y" : 272 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 910, "y" : 272 } }, "reactionShape" : { "a" : { "x" : 1003, "y" : 301 }, "b" : { "x" : 1015, "y" : 313 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1009, "y" : 307 } }, "inputs" : [ { "id" : 132757 } ], "outputs" : [ { "id" : 133340 } ] }, { "id" : 133402, "renderableClass" : "Interaction", "position" : { "x" : 2053, "y" : 298 }, "minX" : 2027, "maxX" : 2505, "minY" : 226, "maxY" : 351, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2027, "y" : 351 }, "to" : { "x" : 2053, "y" : 298 } }, { "from" : { "x" : 2053, "y" : 298 }, "to" : { "x" : 2505, "y" : 226 } } ], "endShape" : { "a" : { "x" : 2499, "y" : 231 }, "b" : { "x" : 2505, "y" : 226 }, "c" : { "x" : 2498, "y" : 223 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2498, "y" : 223 } }, "reactionShape" : { "a" : { "x" : 2047, "y" : 292 }, "b" : { "x" : 2059, "y" : 304 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2053, "y" : 298 } }, "inputs" : [ { "id" : 132737 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133403, "renderableClass" : "Interaction", "position" : { "x" : 2723, "y" : 302 }, "minX" : 2653, "maxX" : 2794, "minY" : 258, "maxY" : 346, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2794, "y" : 346 }, "to" : { "x" : 2653, "y" : 258 } } ], "endShape" : { "a" : { "x" : 2661, "y" : 258 }, "b" : { "x" : 2653, "y" : 258 }, "c" : { "x" : 2657, "y" : 265 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2657, "y" : 265 } }, "reactionShape" : { "a" : { "x" : 2717, "y" : 296 }, "b" : { "x" : 2729, "y" : 308 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2723, "y" : 302 } }, "inputs" : [ { "id" : 132777 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133400, "renderableClass" : "Interaction", "position" : { "x" : 1670, "y" : 289 }, "minX" : 1633, "maxX" : 2505, "minY" : 220, "maxY" : 347, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1633, "y" : 347 }, "to" : { "x" : 1670, "y" : 289 } }, { "from" : { "x" : 1670, "y" : 289 }, "to" : { "x" : 2505, "y" : 220 } } ], "endShape" : { "a" : { "x" : 2498, "y" : 225 }, "b" : { "x" : 2505, "y" : 220 }, "c" : { "x" : 2498, "y" : 217 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2498, "y" : 217 } }, "reactionShape" : { "a" : { "x" : 1664, "y" : 283 }, "b" : { "x" : 1676, "y" : 295 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1670, "y" : 289 } }, "inputs" : [ { "id" : 132765 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133401, "renderableClass" : "Interaction", "position" : { "x" : 1881, "y" : 294 }, "minX" : 1847, "maxX" : 2505, "minY" : 223, "maxY" : 345, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1847, "y" : 345 }, "to" : { "x" : 1881, "y" : 294 } }, { "from" : { "x" : 1881, "y" : 294 }, "to" : { "x" : 2505, "y" : 223 } } ], "endShape" : { "a" : { "x" : 2499, "y" : 228 }, "b" : { "x" : 2505, "y" : 223 }, "c" : { "x" : 2498, "y" : 220 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2498, "y" : 220 } }, "reactionShape" : { "a" : { "x" : 1875, "y" : 288 }, "b" : { "x" : 1887, "y" : 300 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1881, "y" : 294 } }, "inputs" : [ { "id" : 132769 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133406, "renderableClass" : "Interaction", "position" : { "x" : 2594, "y" : 304 }, "minX" : 2588, "maxX" : 2600, "minY" : 258, "maxY" : 350, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2597, "y" : 350 }, "to" : { "x" : 2592, "y" : 258 } } ], "endShape" : { "a" : { "x" : 2596, "y" : 265 }, "b" : { "x" : 2592, "y" : 258 }, "c" : { "x" : 2588, "y" : 265 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2588, "y" : 265 } }, "reactionShape" : { "a" : { "x" : 2588, "y" : 298 }, "b" : { "x" : 2600, "y" : 310 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2594, "y" : 304 } }, "inputs" : [ { "id" : 133178 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133407, "renderableClass" : "Interaction", "position" : { "x" : 3143, "y" : 313 }, "minX" : 2677, "maxX" : 3189, "minY" : 228, "maxY" : 340, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3189, "y" : 340 }, "to" : { "x" : 3143, "y" : 313 } }, { "from" : { "x" : 3143, "y" : 313 }, "to" : { "x" : 2677, "y" : 228 } } ], "endShape" : { "a" : { "x" : 2685, "y" : 225 }, "b" : { "x" : 2677, "y" : 228 }, "c" : { "x" : 2683, "y" : 233 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2683, "y" : 233 } }, "reactionShape" : { "a" : { "x" : 3137, "y" : 307 }, "b" : { "x" : 3149, "y" : 319 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3143, "y" : 313 } }, "inputs" : [ { "id" : 132741 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133404, "renderableClass" : "Interaction", "position" : { "x" : 2500, "y" : 302 }, "minX" : 2453, "maxX" : 2548, "minY" : 258, "maxY" : 346, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2453, "y" : 346 }, "to" : { "x" : 2548, "y" : 258 } } ], "endShape" : { "a" : { "x" : 2546, "y" : 266 }, "b" : { "x" : 2548, "y" : 258 }, "c" : { "x" : 2540, "y" : 260 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2540, "y" : 260 } }, "reactionShape" : { "a" : { "x" : 2494, "y" : 296 }, "b" : { "x" : 2506, "y" : 308 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2500, "y" : 302 } }, "inputs" : [ { "id" : 132773 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133405, "renderableClass" : "Interaction", "position" : { "x" : 2376, "y" : 298 }, "minX" : 2248, "maxX" : 2505, "minY" : 246, "maxY" : 350, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2248, "y" : 350 }, "to" : { "x" : 2505, "y" : 246 } } ], "endShape" : { "a" : { "x" : 2500, "y" : 252 }, "b" : { "x" : 2505, "y" : 246 }, "c" : { "x" : 2497, "y" : 245 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2497, "y" : 245 } }, "reactionShape" : { "a" : { "x" : 2370, "y" : 292 }, "b" : { "x" : 2382, "y" : 304 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2376, "y" : 298 } }, "inputs" : [ { "id" : 133182 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133410, "renderableClass" : "Interaction", "position" : { "x" : 3683, "y" : 283 }, "minX" : 2677, "maxX" : 3753, "minY" : 219, "maxY" : 350, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3753, "y" : 350 }, "to" : { "x" : 3683, "y" : 283 } }, { "from" : { "x" : 3683, "y" : 283 }, "to" : { "x" : 2677, "y" : 219 } } ], "endShape" : { "a" : { "x" : 2684, "y" : 215 }, "b" : { "x" : 2677, "y" : 219 }, "c" : { "x" : 2684, "y" : 223 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2684, "y" : 223 } }, "reactionShape" : { "a" : { "x" : 3677, "y" : 277 }, "b" : { "x" : 3689, "y" : 289 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3683, "y" : 283 } }, "inputs" : [ { "id" : 132789 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133411, "renderableClass" : "Interaction", "position" : { "x" : 3781, "y" : 229 }, "minX" : 2677, "maxX" : 3964, "minY" : 215, "maxY" : 341, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3964, "y" : 341 }, "to" : { "x" : 3781, "y" : 229 } }, { "from" : { "x" : 3781, "y" : 229 }, "to" : { "x" : 2677, "y" : 215 } } ], "endShape" : { "a" : { "x" : 2684, "y" : 211 }, "b" : { "x" : 2677, "y" : 215 }, "c" : { "x" : 2684, "y" : 219 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2684, "y" : 219 } }, "reactionShape" : { "a" : { "x" : 3775, "y" : 223 }, "b" : { "x" : 3787, "y" : 235 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3781, "y" : 229 } }, "inputs" : [ { "id" : 132733 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133408, "renderableClass" : "Interaction", "position" : { "x" : 3294, "y" : 311 }, "minX" : 2677, "maxX" : 3340, "minY" : 225, "maxY" : 340, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3340, "y" : 340 }, "to" : { "x" : 3294, "y" : 311 } }, { "from" : { "x" : 3294, "y" : 311 }, "to" : { "x" : 2677, "y" : 225 } } ], "endShape" : { "a" : { "x" : 2684, "y" : 222 }, "b" : { "x" : 2677, "y" : 225 }, "c" : { "x" : 2683, "y" : 230 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2683, "y" : 230 } }, "reactionShape" : { "a" : { "x" : 3288, "y" : 305 }, "b" : { "x" : 3300, "y" : 317 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3294, "y" : 311 } }, "inputs" : [ { "id" : 132745 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133414, "renderableClass" : "Interaction", "position" : { "x" : 408, "y" : 844 }, "minX" : 341, "maxX" : 476, "minY" : 802, "maxY" : 887, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 341, "y" : 887 }, "to" : { "x" : 476, "y" : 802 } } ], "endShape" : { "a" : { "x" : 472, "y" : 809 }, "b" : { "x" : 476, "y" : 802 }, "c" : { "x" : 468, "y" : 802 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 468, "y" : 802 } }, "reactionShape" : { "a" : { "x" : 402, "y" : 838 }, "b" : { "x" : 414, "y" : 850 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 408, "y" : 844 } }, "inputs" : [ { "id" : 132829 } ], "outputs" : [ { "id" : 133343 } ] }, { "id" : 133415, "renderableClass" : "Interaction", "position" : { "x" : 393, "y" : 660 }, "minX" : 310, "maxX" : 476, "minY" : 603, "maxY" : 718, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 310, "y" : 603 }, "to" : { "x" : 476, "y" : 718 } } ], "endShape" : { "a" : { "x" : 468, "y" : 717 }, "b" : { "x" : 476, "y" : 718 }, "c" : { "x" : 473, "y" : 711 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 473, "y" : 711 } }, "reactionShape" : { "a" : { "x" : 387, "y" : 654 }, "b" : { "x" : 399, "y" : 666 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 393, "y" : 660 } }, "inputs" : [ { "id" : 132833 } ], "outputs" : [ { "id" : 133343 } ] }, { "id" : 133412, "renderableClass" : "Interaction", "position" : { "x" : 1404, "y" : 729 }, "minX" : 1300, "maxX" : 2011, "minY" : 606, "maxY" : 750, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1300, "y" : 606 }, "to" : { "x" : 1404, "y" : 729 } }, { "from" : { "x" : 1404, "y" : 729 }, "to" : { "x" : 2011, "y" : 750 } } ], "endShape" : { "a" : { "x" : 2004, "y" : 754 }, "b" : { "x" : 2011, "y" : 750 }, "c" : { "x" : 2004, "y" : 746 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2004, "y" : 746 } }, "reactionShape" : { "a" : { "x" : 1398, "y" : 723 }, "b" : { "x" : 1410, "y" : 735 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1404, "y" : 729 } }, "inputs" : [ { "id" : 132817 } ], "outputs" : [ { "id" : 133342 } ] }, { "id" : 133413, "renderableClass" : "Interaction", "position" : { "x" : 1604, "y" : 724 }, "minX" : 1525, "maxX" : 2011, "minY" : 606, "maxY" : 749, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1525, "y" : 606 }, "to" : { "x" : 1604, "y" : 724 } }, { "from" : { "x" : 1604, "y" : 724 }, "to" : { "x" : 2011, "y" : 749 } } ], "endShape" : { "a" : { "x" : 2004, "y" : 753 }, "b" : { "x" : 2011, "y" : 749 }, "c" : { "x" : 2004, "y" : 745 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2004, "y" : 745 } }, "reactionShape" : { "a" : { "x" : 1598, "y" : 718 }, "b" : { "x" : 1610, "y" : 730 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1604, "y" : 724 } }, "inputs" : [ { "id" : 132821 } ], "outputs" : [ { "id" : 133342 } ] }, { "id" : 133418, "renderableClass" : "Interaction", "position" : { "x" : 3544, "y" : 645 }, "minX" : 3538, "maxX" : 3550, "minY" : 597, "maxY" : 694, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3544, "y" : 597 }, "to" : { "x" : 3544, "y" : 694 } } ], "endShape" : { "a" : { "x" : 3540, "y" : 687 }, "b" : { "x" : 3544, "y" : 694 }, "c" : { "x" : 3548, "y" : 687 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3548, "y" : 687 } }, "reactionShape" : { "a" : { "x" : 3538, "y" : 639 }, "b" : { "x" : 3550, "y" : 651 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3544, "y" : 645 } }, "inputs" : [ { "id" : 132849 } ], "outputs" : [ { "id" : 133344 } ] }, { "id" : 133419, "renderableClass" : "Interaction", "position" : { "x" : 2579, "y" : 712 }, "minX" : 2147, "maxX" : 2647, "minY" : 601, "maxY" : 747, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2647, "y" : 601 }, "to" : { "x" : 2579, "y" : 712 } }, { "from" : { "x" : 2579, "y" : 712 }, "to" : { "x" : 2147, "y" : 747 } } ], "endShape" : { "a" : { "x" : 2154, "y" : 742 }, "b" : { "x" : 2147, "y" : 747 }, "c" : { "x" : 2154, "y" : 750 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2154, "y" : 750 } }, "reactionShape" : { "a" : { "x" : 2573, "y" : 706 }, "b" : { "x" : 2585, "y" : 718 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2579, "y" : 712 } }, "inputs" : [ { "id" : 132853 } ], "outputs" : [ { "id" : 133342 } ] }, { "id" : 133416, "renderableClass" : "Interaction", "position" : { "x" : 3877, "y" : 730 }, "minX" : 3623, "maxX" : 3973, "minY" : 615, "maxY" : 740, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3973, "y" : 615 }, "to" : { "x" : 3877, "y" : 730 } }, { "from" : { "x" : 3877, "y" : 730 }, "to" : { "x" : 3623, "y" : 740 } } ], "endShape" : { "a" : { "x" : 3630, "y" : 736 }, "b" : { "x" : 3623, "y" : 740 }, "c" : { "x" : 3630, "y" : 744 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3630, "y" : 744 } }, "reactionShape" : { "a" : { "x" : 3871, "y" : 724 }, "b" : { "x" : 3883, "y" : 736 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3877, "y" : 730 } }, "inputs" : [ { "id" : 132841 } ], "outputs" : [ { "id" : 133344 } ] }, { "id" : 133417, "renderableClass" : "Interaction", "position" : { "x" : 1902, "y" : 662 }, "minX" : 1793, "maxX" : 2011, "minY" : 606, "maxY" : 719, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1793, "y" : 606 }, "to" : { "x" : 2011, "y" : 719 } } ], "endShape" : { "a" : { "x" : 2003, "y" : 719 }, "b" : { "x" : 2011, "y" : 719 }, "c" : { "x" : 2007, "y" : 712 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2007, "y" : 712 } }, "reactionShape" : { "a" : { "x" : 1896, "y" : 656 }, "b" : { "x" : 1908, "y" : 668 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1902, "y" : 662 } }, "inputs" : [ { "id" : 132845 } ], "outputs" : [ { "id" : 133342 } ] }, { "id" : 133422, "renderableClass" : "Interaction", "position" : { "x" : 1981, "y" : 652 }, "minX" : 1932, "maxX" : 2031, "minY" : 603, "maxY" : 702, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1932, "y" : 603 }, "to" : { "x" : 2031, "y" : 702 } } ], "endShape" : { "a" : { "x" : 2023, "y" : 700 }, "b" : { "x" : 2031, "y" : 702 }, "c" : { "x" : 2029, "y" : 694 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2029, "y" : 694 } }, "reactionShape" : { "a" : { "x" : 1975, "y" : 646 }, "b" : { "x" : 1987, "y" : 658 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1981, "y" : 652 } }, "inputs" : [ { "id" : 132867 } ], "outputs" : [ { "id" : 133342 } ] }, { "id" : 133423, "renderableClass" : "Interaction", "position" : { "x" : 2165, "y" : 651 }, "minX" : 2120, "maxX" : 2211, "minY" : 601, "maxY" : 702, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2211, "y" : 601 }, "to" : { "x" : 2120, "y" : 702 } } ], "endShape" : { "a" : { "x" : 2122, "y" : 694 }, "b" : { "x" : 2120, "y" : 702 }, "c" : { "x" : 2128, "y" : 700 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2128, "y" : 700 } }, "reactionShape" : { "a" : { "x" : 2159, "y" : 645 }, "b" : { "x" : 2171, "y" : 657 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2165, "y" : 651 } }, "inputs" : [ { "id" : 132873 } ], "outputs" : [ { "id" : 133342 } ] }, { "id" : 133420, "renderableClass" : "Interaction", "position" : { "x" : 2776, "y" : 711 }, "minX" : 2147, "maxX" : 2858, "minY" : 620, "maxY" : 749, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2858, "y" : 620 }, "to" : { "x" : 2776, "y" : 711 } }, { "from" : { "x" : 2776, "y" : 711 }, "to" : { "x" : 2147, "y" : 749 } } ], "endShape" : { "a" : { "x" : 2154, "y" : 745 }, "b" : { "x" : 2147, "y" : 749 }, "c" : { "x" : 2154, "y" : 753 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2154, "y" : 753 } }, "reactionShape" : { "a" : { "x" : 2770, "y" : 705 }, "b" : { "x" : 2782, "y" : 717 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2776, "y" : 711 } }, "inputs" : [ { "id" : 132857 } ], "outputs" : [ { "id" : 133342 } ] }, { "id" : 133421, "renderableClass" : "Interaction", "position" : { "x" : 3012, "y" : 716 }, "minX" : 2147, "maxX" : 3099, "minY" : 598, "maxY" : 750, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3099, "y" : 598 }, "to" : { "x" : 3012, "y" : 716 } }, { "from" : { "x" : 3012, "y" : 716 }, "to" : { "x" : 2147, "y" : 750 } } ], "endShape" : { "a" : { "x" : 2154, "y" : 746 }, "b" : { "x" : 2147, "y" : 750 }, "c" : { "x" : 2154, "y" : 754 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2154, "y" : 754 } }, "reactionShape" : { "a" : { "x" : 3006, "y" : 710 }, "b" : { "x" : 3018, "y" : 722 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3012, "y" : 716 } }, "inputs" : [ { "id" : 132861 } ], "outputs" : [ { "id" : 133342 } ] }, { "id" : 133426, "renderableClass" : "Interaction", "position" : { "x" : 1029, "y" : 770 }, "minX" : 878, "maxX" : 2011, "minY" : 754, "maxY" : 885, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 878, "y" : 885 }, "to" : { "x" : 1029, "y" : 770 } }, { "from" : { "x" : 1029, "y" : 770 }, "to" : { "x" : 2011, "y" : 754 } } ], "endShape" : { "a" : { "x" : 2004, "y" : 758 }, "b" : { "x" : 2011, "y" : 754 }, "c" : { "x" : 2004, "y" : 750 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2004, "y" : 750 } }, "reactionShape" : { "a" : { "x" : 1023, "y" : 764 }, "b" : { "x" : 1035, "y" : 776 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1029, "y" : 770 } }, "inputs" : [ { "id" : 132881 } ], "outputs" : [ { "id" : 133342 } ] }, { "id" : 133424, "renderableClass" : "Interaction", "position" : { "x" : 2367, "y" : 721 }, "minX" : 2147, "maxX" : 2446, "minY" : 593, "maxY" : 745, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2446, "y" : 593 }, "to" : { "x" : 2367, "y" : 721 } }, { "from" : { "x" : 2367, "y" : 721 }, "to" : { "x" : 2147, "y" : 745 } } ], "endShape" : { "a" : { "x" : 2153, "y" : 740 }, "b" : { "x" : 2147, "y" : 745 }, "c" : { "x" : 2154, "y" : 748 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2154, "y" : 748 } }, "reactionShape" : { "a" : { "x" : 2361, "y" : 715 }, "b" : { "x" : 2373, "y" : 727 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2367, "y" : 721 } }, "inputs" : [ { "id" : 132805 } ], "outputs" : [ { "id" : 133342 } ] }, { "id" : 133425, "renderableClass" : "Interaction", "position" : { "x" : 1394, "y" : 785 }, "minX" : 1349, "maxX" : 2011, "minY" : 756, "maxY" : 886, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1349, "y" : 886 }, "to" : { "x" : 1394, "y" : 785 } }, { "from" : { "x" : 1394, "y" : 785 }, "to" : { "x" : 2011, "y" : 756 } } ], "endShape" : { "a" : { "x" : 2004, "y" : 760 }, "b" : { "x" : 2011, "y" : 756 }, "c" : { "x" : 2004, "y" : 752 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2004, "y" : 752 } }, "reactionShape" : { "a" : { "x" : 1388, "y" : 779 }, "b" : { "x" : 1400, "y" : 791 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1394, "y" : 785 } }, "inputs" : [ { "id" : 132877 } ], "outputs" : [ { "id" : 133342 } ] }, { "id" : 133430, "renderableClass" : "Interaction", "position" : { "x" : 778, "y" : 755 }, "minX" : 492, "maxX" : 2011, "minY" : 591, "maxY" : 761, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 492, "y" : 591 }, "to" : { "x" : 778, "y" : 755 } }, { "from" : { "x" : 778, "y" : 755 }, "to" : { "x" : 2011, "y" : 753 } } ], "endShape" : { "a" : { "x" : 2004, "y" : 757 }, "b" : { "x" : 2011, "y" : 753 }, "c" : { "x" : 2004, "y" : 749 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2004, "y" : 749 } }, "reactionShape" : { "a" : { "x" : 772, "y" : 749 }, "b" : { "x" : 784, "y" : 761 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 778, "y" : 755 } }, "inputs" : [ { "id" : 132885 } ], "outputs" : [ { "id" : 133342 } ] }, { "id" : 133431, "renderableClass" : "Interaction", "position" : { "x" : 497, "y" : 657 }, "minX" : 471, "maxX" : 523, "minY" : 600, "maxY" : 714, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 471, "y" : 600 }, "to" : { "x" : 523, "y" : 714 } } ], "endShape" : { "a" : { "x" : 516, "y" : 709 }, "b" : { "x" : 523, "y" : 714 }, "c" : { "x" : 524, "y" : 706 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 524, "y" : 706 } }, "reactionShape" : { "a" : { "x" : 491, "y" : 651 }, "b" : { "x" : 503, "y" : 663 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 497, "y" : 657 } }, "inputs" : [ { "id" : 132885 } ], "outputs" : [ { "id" : 133343 } ] }, { "id" : 133434, "renderableClass" : "Interaction", "position" : { "x" : 620, "y" : 851 }, "minX" : 585, "maxX" : 656, "minY" : 813, "maxY" : 889, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 656, "y" : 889 }, "to" : { "x" : 585, "y" : 813 } } ], "endShape" : { "a" : { "x" : 593, "y" : 815 }, "b" : { "x" : 585, "y" : 813 }, "c" : { "x" : 587, "y" : 821 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 587, "y" : 821 } }, "reactionShape" : { "a" : { "x" : 614, "y" : 845 }, "b" : { "x" : 626, "y" : 857 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 620, "y" : 851 } }, "inputs" : [ { "id" : 132897 } ], "outputs" : [ { "id" : 133343 } ] }, { "id" : 133435, "renderableClass" : "Interaction", "position" : { "x" : 3677, "y" : 846 }, "minX" : 3607, "maxX" : 3748, "minY" : 795, "maxY" : 898, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3748, "y" : 898 }, "to" : { "x" : 3607, "y" : 795 } } ], "endShape" : { "a" : { "x" : 3615, "y" : 796 }, "b" : { "x" : 3607, "y" : 795 }, "c" : { "x" : 3610, "y" : 802 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3610, "y" : 802 } }, "reactionShape" : { "a" : { "x" : 3671, "y" : 840 }, "b" : { "x" : 3683, "y" : 852 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3677, "y" : 846 } }, "inputs" : [ { "id" : 132901 } ], "outputs" : [ { "id" : 133344 } ] }, { "id" : 133432, "renderableClass" : "Interaction", "position" : { "x" : 1210, "y" : 780 }, "minX" : 1123, "maxX" : 2011, "minY" : 755, "maxY" : 887, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1123, "y" : 887 }, "to" : { "x" : 1210, "y" : 780 } }, { "from" : { "x" : 1210, "y" : 780 }, "to" : { "x" : 2011, "y" : 755 } } ], "endShape" : { "a" : { "x" : 2004, "y" : 759 }, "b" : { "x" : 2011, "y" : 755 }, "c" : { "x" : 2004, "y" : 751 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2004, "y" : 751 } }, "reactionShape" : { "a" : { "x" : 1204, "y" : 774 }, "b" : { "x" : 1216, "y" : 786 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1210, "y" : 780 } }, "inputs" : [ { "id" : 132889 } ], "outputs" : [ { "id" : 133342 } ] }, { "id" : 133433, "renderableClass" : "Interaction", "position" : { "x" : 508, "y" : 848 }, "minX" : 493, "maxX" : 524, "minY" : 813, "maxY" : 883, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 493, "y" : 883 }, "to" : { "x" : 524, "y" : 813 } } ], "endShape" : { "a" : { "x" : 525, "y" : 821 }, "b" : { "x" : 524, "y" : 813 }, "c" : { "x" : 518, "y" : 818 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 518, "y" : 818 } }, "reactionShape" : { "a" : { "x" : 502, "y" : 842 }, "b" : { "x" : 514, "y" : 854 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 508, "y" : 848 } }, "inputs" : [ { "id" : 132893 } ], "outputs" : [ { "id" : 133343 } ] }, { "id" : 133438, "renderableClass" : "Interaction", "position" : { "x" : 2160, "y" : 847 }, "minX" : 2121, "maxX" : 2199, "minY" : 804, "maxY" : 890, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2199, "y" : 890 }, "to" : { "x" : 2121, "y" : 804 } } ], "endShape" : { "a" : { "x" : 2129, "y" : 806 }, "b" : { "x" : 2121, "y" : 804 }, "c" : { "x" : 2123, "y" : 812 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2123, "y" : 812 } }, "reactionShape" : { "a" : { "x" : 2154, "y" : 841 }, "b" : { "x" : 2166, "y" : 853 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2160, "y" : 847 } }, "inputs" : [ { "id" : 132913 } ], "outputs" : [ { "id" : 133342 } ] }, { "id" : 133439, "renderableClass" : "Interaction", "position" : { "x" : 2755, "y" : 768 }, "minX" : 2539, "maxX" : 3467, "minY" : 746, "maxY" : 888, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2539, "y" : 888 }, "to" : { "x" : 2755, "y" : 768 } }, { "from" : { "x" : 2755, "y" : 768 }, "to" : { "x" : 3467, "y" : 746 } } ], "endShape" : { "a" : { "x" : 3460, "y" : 750 }, "b" : { "x" : 3467, "y" : 746 }, "c" : { "x" : 3460, "y" : 742 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3460, "y" : 742 } }, "reactionShape" : { "a" : { "x" : 2749, "y" : 762 }, "b" : { "x" : 2761, "y" : 774 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2755, "y" : 768 } }, "inputs" : [ { "id" : 132918 } ], "outputs" : [ { "id" : 133344 } ] }, { "id" : 133442, "renderableClass" : "Interaction", "position" : { "x" : 2507, "y" : 869 }, "minX" : 2501, "maxX" : 2513, "minY" : 850, "maxY" : 888, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2507, "y" : 888 }, "to" : { "x" : 2507, "y" : 850 } } ], "endShape" : { "a" : { "x" : 2511, "y" : 857 }, "b" : { "x" : 2507, "y" : 850 }, "c" : { "x" : 2503, "y" : 857 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2503, "y" : 857 } }, "reactionShape" : { "a" : { "x" : 2501, "y" : 863 }, "b" : { "x" : 2513, "y" : 875 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2507, "y" : 869 } }, "inputs" : [ { "id" : 132918 } ], "outputs" : [ { "id" : 133346 } ] }, { "id" : 133443, "renderableClass" : "Interaction", "position" : { "x" : 491, "y" : 1311 }, "minX" : 477, "maxX" : 1251, "minY" : 1142, "maxY" : 1330, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 477, "y" : 1142 }, "to" : { "x" : 491, "y" : 1311 } }, { "from" : { "x" : 491, "y" : 1311 }, "to" : { "x" : 1251, "y" : 1330 } } ], "endShape" : { "a" : { "x" : 1244, "y" : 1334 }, "b" : { "x" : 1251, "y" : 1330 }, "c" : { "x" : 1244, "y" : 1326 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1244, "y" : 1326 } }, "reactionShape" : { "a" : { "x" : 485, "y" : 1305 }, "b" : { "x" : 497, "y" : 1317 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 491, "y" : 1311 } }, "inputs" : [ { "id" : 132931 } ], "outputs" : [ { "id" : 133348 } ] }, { "id" : 133440, "renderableClass" : "Interaction", "position" : { "x" : 3563, "y" : 1316 }, "minX" : 3127, "maxX" : 3999, "minY" : 1302, "maxY" : 1330, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3999, "y" : 1302 }, "to" : { "x" : 3127, "y" : 1330 } } ], "endShape" : { "a" : { "x" : 3134, "y" : 1326 }, "b" : { "x" : 3127, "y" : 1330 }, "c" : { "x" : 3134, "y" : 1334 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3134, "y" : 1334 } }, "reactionShape" : { "a" : { "x" : 3557, "y" : 1310 }, "b" : { "x" : 3569, "y" : 1322 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3563, "y" : 1316 } }, "inputs" : [ { "id" : 132922 } ], "outputs" : [ { "id" : 133350 } ] }, { "id" : 133441, "renderableClass" : "Interaction", "position" : { "x" : 1848, "y" : 778 }, "minX" : 1776, "maxX" : 2011, "minY" : 760, "maxY" : 890, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1776, "y" : 890 }, "to" : { "x" : 1848, "y" : 778 } }, { "from" : { "x" : 1848, "y" : 778 }, "to" : { "x" : 2011, "y" : 760 } } ], "endShape" : { "a" : { "x" : 2005, "y" : 765 }, "b" : { "x" : 2011, "y" : 760 }, "c" : { "x" : 2004, "y" : 757 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2004, "y" : 757 } }, "reactionShape" : { "a" : { "x" : 1842, "y" : 772 }, "b" : { "x" : 1854, "y" : 784 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1848, "y" : 778 } }, "inputs" : [ { "id" : 133174 } ], "outputs" : [ { "id" : 133342 } ] }, { "id" : 133446, "renderableClass" : "Interaction", "position" : { "x" : 1447, "y" : 1262 }, "minX" : 1381, "maxX" : 2126, "minY" : 1149, "maxY" : 1323, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1381, "y" : 1149 }, "to" : { "x" : 1447, "y" : 1262 } }, { "from" : { "x" : 1447, "y" : 1262 }, "to" : { "x" : 2126, "y" : 1323 } } ], "endShape" : { "a" : { "x" : 2119, "y" : 1326 }, "b" : { "x" : 2126, "y" : 1323 }, "c" : { "x" : 2119, "y" : 1318 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2119, "y" : 1318 } }, "reactionShape" : { "a" : { "x" : 1441, "y" : 1256 }, "b" : { "x" : 1453, "y" : 1268 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1447, "y" : 1262 } }, "inputs" : [ { "id" : 132947 } ], "outputs" : [ { "id" : 133349 } ] }, { "id" : 133447, "renderableClass" : "Interaction", "position" : { "x" : 1648, "y" : 1216 }, "minX" : 1589, "maxX" : 2974, "minY" : 1145, "maxY" : 1326, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1589, "y" : 1145 }, "to" : { "x" : 1648, "y" : 1216 } }, { "from" : { "x" : 1648, "y" : 1216 }, "to" : { "x" : 2974, "y" : 1326 } } ], "endShape" : { "a" : { "x" : 2967, "y" : 1329 }, "b" : { "x" : 2974, "y" : 1326 }, "c" : { "x" : 2967, "y" : 1321 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2967, "y" : 1321 } }, "reactionShape" : { "a" : { "x" : 1642, "y" : 1210 }, "b" : { "x" : 1654, "y" : 1222 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1648, "y" : 1216 } }, "inputs" : [ { "id" : 132950 } ], "outputs" : [ { "id" : 133350 } ] }, { "id" : 133444, "renderableClass" : "Interaction", "position" : { "x" : 674, "y" : 1212 }, "minX" : 596, "maxX" : 2126, "minY" : 1145, "maxY" : 1324, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 596, "y" : 1145 }, "to" : { "x" : 674, "y" : 1212 } }, { "from" : { "x" : 674, "y" : 1212 }, "to" : { "x" : 2126, "y" : 1324 } } ], "endShape" : { "a" : { "x" : 2119, "y" : 1327 }, "b" : { "x" : 2126, "y" : 1324 }, "c" : { "x" : 2119, "y" : 1319 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2119, "y" : 1319 } }, "reactionShape" : { "a" : { "x" : 668, "y" : 1206 }, "b" : { "x" : 680, "y" : 1218 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 674, "y" : 1212 } }, "inputs" : [ { "id" : 132932 } ], "outputs" : [ { "id" : 133349 } ] }, { "id" : 133445, "renderableClass" : "Interaction", "position" : { "x" : 1225, "y" : 1219 }, "minX" : 1166, "maxX" : 1284, "minY" : 1147, "maxY" : 1292, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1166, "y" : 1147 }, "to" : { "x" : 1284, "y" : 1292 } } ], "endShape" : { "a" : { "x" : 1277, "y" : 1289 }, "b" : { "x" : 1284, "y" : 1292 }, "c" : { "x" : 1283, "y" : 1284 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1283, "y" : 1284 } }, "reactionShape" : { "a" : { "x" : 1219, "y" : 1213 }, "b" : { "x" : 1231, "y" : 1225 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1225, "y" : 1219 } }, "inputs" : [ { "id" : 132944 } ], "outputs" : [ { "id" : 133348 } ] }, { "id" : 133450, "renderableClass" : "Interaction", "position" : { "x" : 2468, "y" : 1265 }, "minX" : 2265, "maxX" : 2974, "minY" : 1153, "maxY" : 1324, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2265, "y" : 1153 }, "to" : { "x" : 2468, "y" : 1265 } }, { "from" : { "x" : 2468, "y" : 1265 }, "to" : { "x" : 2974, "y" : 1324 } } ], "endShape" : { "a" : { "x" : 2967, "y" : 1327 }, "b" : { "x" : 2974, "y" : 1324 }, "c" : { "x" : 2968, "y" : 1319 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2968, "y" : 1319 } }, "reactionShape" : { "a" : { "x" : 2462, "y" : 1259 }, "b" : { "x" : 2474, "y" : 1271 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2468, "y" : 1265 } }, "inputs" : [ { "id" : 132954 } ], "outputs" : [ { "id" : 133350 } ] }, { "id" : 133451, "renderableClass" : "Interaction", "position" : { "x" : 2531, "y" : 1261 }, "minX" : 2451, "maxX" : 2974, "minY" : 1149, "maxY" : 1322, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2451, "y" : 1149 }, "to" : { "x" : 2531, "y" : 1261 } }, { "from" : { "x" : 2531, "y" : 1261 }, "to" : { "x" : 2974, "y" : 1322 } } ], "endShape" : { "a" : { "x" : 2967, "y" : 1325 }, "b" : { "x" : 2974, "y" : 1322 }, "c" : { "x" : 2968, "y" : 1317 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2968, "y" : 1317 } }, "reactionShape" : { "a" : { "x" : 2525, "y" : 1255 }, "b" : { "x" : 2537, "y" : 1267 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2531, "y" : 1261 } }, "inputs" : [ { "id" : 133113 } ], "outputs" : [ { "id" : 133350 } ] }, { "id" : 133448, "renderableClass" : "Interaction", "position" : { "x" : 1886, "y" : 1219 }, "minX" : 1811, "maxX" : 2974, "minY" : 1147, "maxY" : 1325, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1811, "y" : 1147 }, "to" : { "x" : 1886, "y" : 1219 } }, { "from" : { "x" : 1886, "y" : 1219 }, "to" : { "x" : 2974, "y" : 1325 } } ], "endShape" : { "a" : { "x" : 2967, "y" : 1328 }, "b" : { "x" : 2974, "y" : 1325 }, "c" : { "x" : 2967, "y" : 1320 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2967, "y" : 1320 } }, "reactionShape" : { "a" : { "x" : 1880, "y" : 1213 }, "b" : { "x" : 1892, "y" : 1225 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1886, "y" : 1219 } }, "inputs" : [ { "id" : 132958 } ], "outputs" : [ { "id" : 133350 } ] }, { "id" : 133449, "renderableClass" : "Interaction", "position" : { "x" : 1724, "y" : 2642 }, "minX" : 902, "maxX" : 1895, "minY" : 2570, "maxY" : 2690, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1895, "y" : 2690 }, "to" : { "x" : 1724, "y" : 2642 } }, { "from" : { "x" : 1724, "y" : 2642 }, "to" : { "x" : 902, "y" : 2570 } } ], "endShape" : { "a" : { "x" : 909, "y" : 2567 }, "b" : { "x" : 902, "y" : 2570 }, "c" : { "x" : 909, "y" : 2575 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 909, "y" : 2575 } }, "reactionShape" : { "a" : { "x" : 1718, "y" : 2636 }, "b" : { "x" : 1730, "y" : 2648 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1724, "y" : 2642 } }, "inputs" : [ { "id" : 132962 } ], "outputs" : [ { "id" : 133357 } ] }, { "id" : 133454, "renderableClass" : "Interaction", "position" : { "x" : 2550, "y" : 1357 }, "minX" : 2295, "maxX" : 2630, "minY" : 1144, "maxY" : 1363, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2630, "y" : 1144 }, "to" : { "x" : 2550, "y" : 1357 } }, { "from" : { "x" : 2550, "y" : 1357 }, "to" : { "x" : 2295, "y" : 1337 } } ], "endShape" : { "a" : { "x" : 2302, "y" : 1334 }, "b" : { "x" : 2295, "y" : 1337 }, "c" : { "x" : 2302, "y" : 1342 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2302, "y" : 1342 } }, "reactionShape" : { "a" : { "x" : 2544, "y" : 1351 }, "b" : { "x" : 2556, "y" : 1363 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2550, "y" : 1357 } }, "inputs" : [ { "id" : 132974 } ], "outputs" : [ { "id" : 133349 } ] }, { "id" : 133455, "renderableClass" : "Interaction", "position" : { "x" : 2956, "y" : 1223 }, "minX" : 2889, "maxX" : 3024, "minY" : 1147, "maxY" : 1300, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2889, "y" : 1147 }, "to" : { "x" : 3024, "y" : 1300 } } ], "endShape" : { "a" : { "x" : 3016, "y" : 1297 }, "b" : { "x" : 3024, "y" : 1300 }, "c" : { "x" : 3022, "y" : 1292 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3022, "y" : 1292 } }, "reactionShape" : { "a" : { "x" : 2950, "y" : 1217 }, "b" : { "x" : 2962, "y" : 1229 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2956, "y" : 1223 } }, "inputs" : [ { "id" : 132977 } ], "outputs" : [ { "id" : 133350 } ] }, { "id" : 133452, "renderableClass" : "Interaction", "position" : { "x" : 3538, "y" : 1214 }, "minX" : 3127, "maxX" : 3585, "minY" : 1149, "maxY" : 1315, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3585, "y" : 1149 }, "to" : { "x" : 3538, "y" : 1214 } }, { "from" : { "x" : 3538, "y" : 1214 }, "to" : { "x" : 3127, "y" : 1315 } } ], "endShape" : { "a" : { "x" : 3133, "y" : 1309 }, "b" : { "x" : 3127, "y" : 1315 }, "c" : { "x" : 3135, "y" : 1317 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3135, "y" : 1317 } }, "reactionShape" : { "a" : { "x" : 3532, "y" : 1208 }, "b" : { "x" : 3544, "y" : 1220 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3538, "y" : 1214 } }, "inputs" : [ { "id" : 132966 } ], "outputs" : [ { "id" : 133350 } ] }, { "id" : 133453, "renderableClass" : "Interaction", "position" : { "x" : 3575, "y" : 1236 }, "minX" : 3127, "maxX" : 3775, "minY" : 1142, "maxY" : 1319, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3775, "y" : 1142 }, "to" : { "x" : 3575, "y" : 1236 } }, { "from" : { "x" : 3575, "y" : 1236 }, "to" : { "x" : 3127, "y" : 1319 } } ], "endShape" : { "a" : { "x" : 3133, "y" : 1314 }, "b" : { "x" : 3127, "y" : 1319 }, "c" : { "x" : 3135, "y" : 1322 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3135, "y" : 1322 } }, "reactionShape" : { "a" : { "x" : 3569, "y" : 1230 }, "b" : { "x" : 3581, "y" : 1242 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3575, "y" : 1236 } }, "inputs" : [ { "id" : 132970 } ], "outputs" : [ { "id" : 133350 } ] }, { "id" : 133458, "renderableClass" : "Interaction", "position" : { "x" : 1492, "y" : 1426 }, "minX" : 1429, "maxX" : 2126, "minY" : 1341, "maxY" : 1589, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1429, "y" : 1589 }, "to" : { "x" : 1492, "y" : 1426 } }, { "from" : { "x" : 1492, "y" : 1426 }, "to" : { "x" : 2126, "y" : 1341 } } ], "endShape" : { "a" : { "x" : 2120, "y" : 1346 }, "b" : { "x" : 2126, "y" : 1341 }, "c" : { "x" : 2119, "y" : 1338 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2119, "y" : 1338 } }, "reactionShape" : { "a" : { "x" : 1486, "y" : 1420 }, "b" : { "x" : 1498, "y" : 1432 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1492, "y" : 1426 } }, "inputs" : [ { "id" : 132992 } ], "outputs" : [ { "id" : 133349 } ] }, { "id" : 133459, "renderableClass" : "Interaction", "position" : { "x" : 1390, "y" : 1578 }, "minX" : 1378, "maxX" : 1402, "minY" : 1568, "maxY" : 1589, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1402, "y" : 1589 }, "to" : { "x" : 1378, "y" : 1568 } } ], "endShape" : { "a" : { "x" : 1386, "y" : 1570 }, "b" : { "x" : 1378, "y" : 1568 }, "c" : { "x" : 1381, "y" : 1576 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1381, "y" : 1576 } }, "reactionShape" : { "a" : { "x" : 1384, "y" : 1572 }, "b" : { "x" : 1396, "y" : 1584 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1390, "y" : 1578 } }, "inputs" : [ { "id" : 132992 } ], "outputs" : [ { "id" : 133351 } ] }, { "id" : 133456, "renderableClass" : "Interaction", "position" : { "x" : 3022, "y" : 1161 }, "minX" : 1377, "maxX" : 3038, "minY" : 1140, "maxY" : 1325, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3038, "y" : 1140 }, "to" : { "x" : 3022, "y" : 1161 } }, { "from" : { "x" : 3022, "y" : 1161 }, "to" : { "x" : 1377, "y" : 1325 } } ], "endShape" : { "a" : { "x" : 1383, "y" : 1320 }, "b" : { "x" : 1377, "y" : 1325 }, "c" : { "x" : 1384, "y" : 1328 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1384, "y" : 1328 } }, "reactionShape" : { "a" : { "x" : 3016, "y" : 1155 }, "b" : { "x" : 3028, "y" : 1167 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3022, "y" : 1161 } }, "inputs" : [ { "id" : 132980 } ], "outputs" : [ { "id" : 133348 } ] }, { "id" : 133457, "renderableClass" : "Interaction", "position" : { "x" : 3138, "y" : 1219 }, "minX" : 3073, "maxX" : 3203, "minY" : 1139, "maxY" : 1300, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3203, "y" : 1139 }, "to" : { "x" : 3073, "y" : 1300 } } ], "endShape" : { "a" : { "x" : 3074, "y" : 1292 }, "b" : { "x" : 3073, "y" : 1300 }, "c" : { "x" : 3080, "y" : 1297 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3080, "y" : 1297 } }, "reactionShape" : { "a" : { "x" : 3132, "y" : 1213 }, "b" : { "x" : 3144, "y" : 1225 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3138, "y" : 1219 } }, "inputs" : [ { "id" : 132988 } ], "outputs" : [ { "id" : 133350 } ] }, { "id" : 133462, "renderableClass" : "Interaction", "position" : { "x" : 1717, "y" : 1403 }, "minX" : 1665, "maxX" : 2126, "minY" : 1342, "maxY" : 1586, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1665, "y" : 1586 }, "to" : { "x" : 1717, "y" : 1403 } }, { "from" : { "x" : 1717, "y" : 1403 }, "to" : { "x" : 2126, "y" : 1342 } } ], "endShape" : { "a" : { "x" : 2120, "y" : 1347 }, "b" : { "x" : 2126, "y" : 1342 }, "c" : { "x" : 2119, "y" : 1339 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2119, "y" : 1339 } }, "reactionShape" : { "a" : { "x" : 1711, "y" : 1397 }, "b" : { "x" : 1723, "y" : 1409 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1717, "y" : 1403 } }, "inputs" : [ { "id" : 133003 } ], "outputs" : [ { "id" : 133349 } ] }, { "id" : 133463, "renderableClass" : "Interaction", "position" : { "x" : 962, "y" : 1484 }, "minX" : 865, "maxX" : 2126, "minY" : 1340, "maxY" : 1592, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 865, "y" : 1592 }, "to" : { "x" : 962, "y" : 1484 } }, { "from" : { "x" : 962, "y" : 1484 }, "to" : { "x" : 2126, "y" : 1340 } } ], "endShape" : { "a" : { "x" : 2120, "y" : 1345 }, "b" : { "x" : 2126, "y" : 1340 }, "c" : { "x" : 2119, "y" : 1337 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2119, "y" : 1337 } }, "reactionShape" : { "a" : { "x" : 956, "y" : 1478 }, "b" : { "x" : 968, "y" : 1490 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 962, "y" : 1484 } }, "inputs" : [ { "id" : 133019 } ], "outputs" : [ { "id" : 133349 } ] }, { "id" : 133460, "renderableClass" : "Interaction", "position" : { "x" : 367, "y" : 1562 }, "minX" : 343, "maxX" : 2974, "minY" : 1339, "maxY" : 1589, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 343, "y" : 1589 }, "to" : { "x" : 367, "y" : 1562 } }, { "from" : { "x" : 367, "y" : 1562 }, "to" : { "x" : 2974, "y" : 1339 } } ], "endShape" : { "a" : { "x" : 2967, "y" : 1344 }, "b" : { "x" : 2974, "y" : 1339 }, "c" : { "x" : 2967, "y" : 1336 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2967, "y" : 1336 } }, "reactionShape" : { "a" : { "x" : 361, "y" : 1556 }, "b" : { "x" : 373, "y" : 1568 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 367, "y" : 1562 } }, "inputs" : [ { "id" : 132996 } ], "outputs" : [ { "id" : 133350 } ] }, { "id" : 133461, "renderableClass" : "Interaction", "position" : { "x" : 689, "y" : 1330 }, "minX" : 524, "maxX" : 1251, "minY" : 1324, "maxY" : 1594, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 524, "y" : 1594 }, "to" : { "x" : 689, "y" : 1330 } }, { "from" : { "x" : 689, "y" : 1330 }, "to" : { "x" : 1251, "y" : 1331 } } ], "endShape" : { "a" : { "x" : 1244, "y" : 1335 }, "b" : { "x" : 1251, "y" : 1331 }, "c" : { "x" : 1244, "y" : 1327 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1244, "y" : 1327 } }, "reactionShape" : { "a" : { "x" : 683, "y" : 1324 }, "b" : { "x" : 695, "y" : 1336 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 689, "y" : 1330 } }, "inputs" : [ { "id" : 132999 } ], "outputs" : [ { "id" : 133348 } ] }, { "id" : 133466, "renderableClass" : "Interaction", "position" : { "x" : 2357, "y" : 1485 }, "minX" : 2245, "maxX" : 2469, "minY" : 1371, "maxY" : 1599, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2469, "y" : 1599 }, "to" : { "x" : 2245, "y" : 1371 } } ], "endShape" : { "a" : { "x" : 2253, "y" : 1373 }, "b" : { "x" : 2245, "y" : 1371 }, "c" : { "x" : 2247, "y" : 1379 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2247, "y" : 1379 } }, "reactionShape" : { "a" : { "x" : 2351, "y" : 1479 }, "b" : { "x" : 2363, "y" : 1491 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2357, "y" : 1485 } }, "inputs" : [ { "id" : 133031 } ], "outputs" : [ { "id" : 133349 } ] }, { "id" : 133467, "renderableClass" : "Interaction", "position" : { "x" : 2758, "y" : 1486 }, "minX" : 2524, "maxX" : 2992, "minY" : 1366, "maxY" : 1607, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2524, "y" : 1607 }, "to" : { "x" : 2992, "y" : 1366 } } ], "endShape" : { "a" : { "x" : 2988, "y" : 1373 }, "b" : { "x" : 2992, "y" : 1366 }, "c" : { "x" : 2984, "y" : 1366 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2984, "y" : 1366 } }, "reactionShape" : { "a" : { "x" : 2752, "y" : 1480 }, "b" : { "x" : 2764, "y" : 1492 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2758, "y" : 1486 } }, "inputs" : [ { "id" : 133031 } ], "outputs" : [ { "id" : 133350 } ] }, { "id" : 133464, "renderableClass" : "Interaction", "position" : { "x" : 1291, "y" : 1409 }, "minX" : 1228, "maxX" : 1302, "minY" : 1372, "maxY" : 1590, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1228, "y" : 1590 }, "to" : { "x" : 1291, "y" : 1409 } }, { "from" : { "x" : 1291, "y" : 1409 }, "to" : { "x" : 1302, "y" : 1372 } } ], "endShape" : { "a" : { "x" : 1304, "y" : 1380 }, "b" : { "x" : 1302, "y" : 1372 }, "c" : { "x" : 1296, "y" : 1378 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1296, "y" : 1378 } }, "reactionShape" : { "a" : { "x" : 1285, "y" : 1403 }, "b" : { "x" : 1297, "y" : 1415 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1291, "y" : 1409 } }, "inputs" : [ { "id" : 133026 } ], "outputs" : [ { "id" : 133348 } ] }, { "id" : 133465, "renderableClass" : "Interaction", "position" : { "x" : 2009, "y" : 1484 }, "minX" : 1858, "maxX" : 2161, "minY" : 1371, "maxY" : 1598, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1858, "y" : 1598 }, "to" : { "x" : 2161, "y" : 1371 } } ], "endShape" : { "a" : { "x" : 2158, "y" : 1378 }, "b" : { "x" : 2161, "y" : 1371 }, "c" : { "x" : 2153, "y" : 1372 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2153, "y" : 1372 } }, "reactionShape" : { "a" : { "x" : 2003, "y" : 1478 }, "b" : { "x" : 2015, "y" : 1490 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2009, "y" : 1484 } }, "inputs" : [ { "id" : 133023 } ], "outputs" : [ { "id" : 133349 } ] }, { "id" : 133470, "renderableClass" : "Interaction", "position" : { "x" : 2183, "y" : 1483 }, "minX" : 2163, "maxX" : 2203, "minY" : 1371, "maxY" : 1595, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2163, "y" : 1595 }, "to" : { "x" : 2203, "y" : 1371 } } ], "endShape" : { "a" : { "x" : 2206, "y" : 1379 }, "b" : { "x" : 2203, "y" : 1371 }, "c" : { "x" : 2198, "y" : 1377 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2198, "y" : 1377 } }, "reactionShape" : { "a" : { "x" : 2177, "y" : 1477 }, "b" : { "x" : 2189, "y" : 1489 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2183, "y" : 1483 } }, "inputs" : [ { "id" : 133048 } ], "outputs" : [ { "id" : 133349 } ] }, { "id" : 133471, "renderableClass" : "Interaction", "position" : { "x" : 2262, "y" : 1484 }, "minX" : 2222, "maxX" : 2303, "minY" : 1371, "maxY" : 1598, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2303, "y" : 1598 }, "to" : { "x" : 2222, "y" : 1371 } } ], "endShape" : { "a" : { "x" : 2228, "y" : 1376 }, "b" : { "x" : 2222, "y" : 1371 }, "c" : { "x" : 2221, "y" : 1379 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2221, "y" : 1379 } }, "reactionShape" : { "a" : { "x" : 2256, "y" : 1478 }, "b" : { "x" : 2268, "y" : 1490 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2262, "y" : 1484 } }, "inputs" : [ { "id" : 133051 } ], "outputs" : [ { "id" : 133349 } ] }, { "id" : 133468, "renderableClass" : "Interaction", "position" : { "x" : 828, "y" : 1342 }, "minX" : 723, "maxX" : 1251, "minY" : 1333, "maxY" : 1594, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 723, "y" : 1594 }, "to" : { "x" : 828, "y" : 1342 } }, { "from" : { "x" : 828, "y" : 1342 }, "to" : { "x" : 1251, "y" : 1333 } } ], "endShape" : { "a" : { "x" : 1244, "y" : 1337 }, "b" : { "x" : 1251, "y" : 1333 }, "c" : { "x" : 1244, "y" : 1329 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1244, "y" : 1329 } }, "reactionShape" : { "a" : { "x" : 822, "y" : 1336 }, "b" : { "x" : 834, "y" : 1348 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 828, "y" : 1342 } }, "inputs" : [ { "id" : 133035 } ], "outputs" : [ { "id" : 133348 } ] }, { "id" : 133469, "renderableClass" : "Interaction", "position" : { "x" : 2104, "y" : 1484 }, "minX" : 2025, "maxX" : 2184, "minY" : 1371, "maxY" : 1597, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2025, "y" : 1597 }, "to" : { "x" : 2184, "y" : 1371 } } ], "endShape" : { "a" : { "x" : 2183, "y" : 1379 }, "b" : { "x" : 2184, "y" : 1371 }, "c" : { "x" : 2177, "y" : 1374 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2177, "y" : 1374 } }, "reactionShape" : { "a" : { "x" : 2098, "y" : 1478 }, "b" : { "x" : 2110, "y" : 1490 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2104, "y" : 1484 } }, "inputs" : [ { "id" : 133045 } ], "outputs" : [ { "id" : 133349 } ] }, { "id" : 133474, "renderableClass" : "Interaction", "position" : { "x" : 3225, "y" : 1531 }, "minX" : 1377, "maxX" : 3285, "minY" : 1338, "maxY" : 1590, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3285, "y" : 1590 }, "to" : { "x" : 3225, "y" : 1531 } }, { "from" : { "x" : 3225, "y" : 1531 }, "to" : { "x" : 1377, "y" : 1338 } } ], "endShape" : { "a" : { "x" : 1384, "y" : 1335 }, "b" : { "x" : 1377, "y" : 1338 }, "c" : { "x" : 1383, "y" : 1343 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1383, "y" : 1343 } }, "reactionShape" : { "a" : { "x" : 3219, "y" : 1525 }, "b" : { "x" : 3231, "y" : 1537 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3225, "y" : 1531 } }, "inputs" : [ { "id" : 133011 } ], "outputs" : [ { "id" : 133348 } ] }, { "id" : 133475, "renderableClass" : "Interaction", "position" : { "x" : 3285, "y" : 1474 }, "minX" : 2295, "maxX" : 3396, "minY" : 1341, "maxY" : 1606, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3396, "y" : 1606 }, "to" : { "x" : 3285, "y" : 1474 } }, { "from" : { "x" : 3285, "y" : 1474 }, "to" : { "x" : 2295, "y" : 1341 } } ], "endShape" : { "a" : { "x" : 2302, "y" : 1338 }, "b" : { "x" : 2295, "y" : 1341 }, "c" : { "x" : 2301, "y" : 1346 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2301, "y" : 1346 } }, "reactionShape" : { "a" : { "x" : 3279, "y" : 1468 }, "b" : { "x" : 3291, "y" : 1480 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3285, "y" : 1474 } }, "inputs" : [ { "id" : 133041 } ], "outputs" : [ { "id" : 133349 } ] }, { "id" : 133472, "renderableClass" : "Interaction", "position" : { "x" : 2657, "y" : 1487 }, "minX" : 1377, "maxX" : 2704, "minY" : 1338, "maxY" : 1601, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2704, "y" : 1601 }, "to" : { "x" : 2657, "y" : 1487 } }, { "from" : { "x" : 2657, "y" : 1487 }, "to" : { "x" : 1377, "y" : 1338 } } ], "endShape" : { "a" : { "x" : 1384, "y" : 1335 }, "b" : { "x" : 1377, "y" : 1338 }, "c" : { "x" : 1383, "y" : 1343 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1383, "y" : 1343 } }, "reactionShape" : { "a" : { "x" : 2651, "y" : 1481 }, "b" : { "x" : 2663, "y" : 1493 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2657, "y" : 1487 } }, "inputs" : [ { "id" : 133055 } ], "outputs" : [ { "id" : 133348 } ] }, { "id" : 133473, "renderableClass" : "Interaction", "position" : { "x" : 2871, "y" : 1504 }, "minX" : 1377, "maxX" : 2901, "minY" : 1338, "maxY" : 1599, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2901, "y" : 1599 }, "to" : { "x" : 2871, "y" : 1504 } }, { "from" : { "x" : 2871, "y" : 1504 }, "to" : { "x" : 1377, "y" : 1338 } } ], "endShape" : { "a" : { "x" : 1384, "y" : 1335 }, "b" : { "x" : 1377, "y" : 1338 }, "c" : { "x" : 1383, "y" : 1343 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1383, "y" : 1343 } }, "reactionShape" : { "a" : { "x" : 2865, "y" : 1498 }, "b" : { "x" : 2877, "y" : 1510 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2871, "y" : 1504 } }, "inputs" : [ { "id" : 133015 } ], "outputs" : [ { "id" : 133348 } ] }, { "id" : 133478, "renderableClass" : "Interaction", "position" : { "x" : 3713, "y" : 1427 }, "minX" : 3127, "maxX" : 3919, "minY" : 1343, "maxY" : 1592, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3919, "y" : 1592 }, "to" : { "x" : 3713, "y" : 1427 } }, { "from" : { "x" : 3713, "y" : 1427 }, "to" : { "x" : 3127, "y" : 1343 } } ], "endShape" : { "a" : { "x" : 3134, "y" : 1340 }, "b" : { "x" : 3127, "y" : 1343 }, "c" : { "x" : 3133, "y" : 1348 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3133, "y" : 1348 } }, "reactionShape" : { "a" : { "x" : 3707, "y" : 1421 }, "b" : { "x" : 3719, "y" : 1433 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3713, "y" : 1427 } }, "inputs" : [ { "id" : 133062 } ], "outputs" : [ { "id" : 133350 } ] }, { "id" : 133479, "renderableClass" : "Interaction", "position" : { "x" : 403, "y" : 2102 }, "minX" : 348, "maxX" : 1070, "minY" : 1997, "maxY" : 2108, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 348, "y" : 1997 }, "to" : { "x" : 403, "y" : 2102 } }, { "from" : { "x" : 403, "y" : 2102 }, "to" : { "x" : 1070, "y" : 2105 } } ], "endShape" : { "a" : { "x" : 1063, "y" : 2109 }, "b" : { "x" : 1070, "y" : 2105 }, "c" : { "x" : 1063, "y" : 2101 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1063, "y" : 2101 } }, "reactionShape" : { "a" : { "x" : 397, "y" : 2096 }, "b" : { "x" : 409, "y" : 2108 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 403, "y" : 2102 } }, "inputs" : [ { "id" : 133074 } ], "outputs" : [ { "id" : 133353 } ] }, { "id" : 133476, "renderableClass" : "Interaction", "position" : { "x" : 3304, "y" : 1464 }, "minX" : 2295, "maxX" : 3539, "minY" : 1340, "maxY" : 1604, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3539, "y" : 1604 }, "to" : { "x" : 3304, "y" : 1464 } }, { "from" : { "x" : 3304, "y" : 1464 }, "to" : { "x" : 2295, "y" : 1340 } } ], "endShape" : { "a" : { "x" : 2302, "y" : 1337 }, "b" : { "x" : 2295, "y" : 1340 }, "c" : { "x" : 2301, "y" : 1345 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2301, "y" : 1345 } }, "reactionShape" : { "a" : { "x" : 3298, "y" : 1458 }, "b" : { "x" : 3310, "y" : 1470 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3304, "y" : 1464 } }, "inputs" : [ { "id" : 133039 } ], "outputs" : [ { "id" : 133349 } ] }, { "id" : 133477, "renderableClass" : "Interaction", "position" : { "x" : 3742, "y" : 1573 }, "minX" : 1377, "maxX" : 3748, "minY" : 1337, "maxY" : 1594, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3746, "y" : 1594 }, "to" : { "x" : 3742, "y" : 1573 } }, { "from" : { "x" : 3742, "y" : 1573 }, "to" : { "x" : 1377, "y" : 1337 } } ], "endShape" : { "a" : { "x" : 1384, "y" : 1334 }, "b" : { "x" : 1377, "y" : 1337 }, "c" : { "x" : 1383, "y" : 1342 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1383, "y" : 1342 } }, "reactionShape" : { "a" : { "x" : 3736, "y" : 1567 }, "b" : { "x" : 3748, "y" : 1579 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3742, "y" : 1573 } }, "inputs" : [ { "id" : 133059 } ], "outputs" : [ { "id" : 133348 } ] }, { "id" : 133482, "renderableClass" : "Interaction", "position" : { "x" : 744, "y" : 2080 }, "minX" : 680, "maxX" : 1070, "minY" : 1986, "maxY" : 2102, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 680, "y" : 1986 }, "to" : { "x" : 744, "y" : 2080 } }, { "from" : { "x" : 744, "y" : 2080 }, "to" : { "x" : 1070, "y" : 2102 } } ], "endShape" : { "a" : { "x" : 1063, "y" : 2106 }, "b" : { "x" : 1070, "y" : 2102 }, "c" : { "x" : 1063, "y" : 2098 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1063, "y" : 2098 } }, "reactionShape" : { "a" : { "x" : 738, "y" : 2074 }, "b" : { "x" : 750, "y" : 2086 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 744, "y" : 2080 } }, "inputs" : [ { "id" : 133082 } ], "outputs" : [ { "id" : 133353 } ] }, { "id" : 133483, "renderableClass" : "Interaction", "position" : { "x" : 2877, "y" : 2144 }, "minX" : 2795, "maxX" : 2988, "minY" : 2138, "maxY" : 2210, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2988, "y" : 2210 }, "to" : { "x" : 2877, "y" : 2144 } }, { "from" : { "x" : 2877, "y" : 2144 }, "to" : { "x" : 2795, "y" : 2144 } } ], "endShape" : { "a" : { "x" : 2802, "y" : 2140 }, "b" : { "x" : 2795, "y" : 2144 }, "c" : { "x" : 2802, "y" : 2148 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2802, "y" : 2148 } }, "reactionShape" : { "a" : { "x" : 2871, "y" : 2138 }, "b" : { "x" : 2883, "y" : 2150 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2877, "y" : 2144 } }, "inputs" : [ { "id" : 133070 } ], "outputs" : [ { "id" : 133354 } ] }, { "id" : 133480, "renderableClass" : "Interaction", "position" : { "x" : 1912, "y" : 2024 }, "minX" : 1191, "maxX" : 2108, "minY" : 1983, "maxY" : 2099, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2108, "y" : 1983 }, "to" : { "x" : 1912, "y" : 2024 } }, { "from" : { "x" : 1912, "y" : 2024 }, "to" : { "x" : 1191, "y" : 2099 } } ], "endShape" : { "a" : { "x" : 1197, "y" : 2094 }, "b" : { "x" : 1191, "y" : 2099 }, "c" : { "x" : 1198, "y" : 2102 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1198, "y" : 2102 } }, "reactionShape" : { "a" : { "x" : 1906, "y" : 2018 }, "b" : { "x" : 1918, "y" : 2030 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1912, "y" : 2024 } }, "inputs" : [ { "id" : 133078 } ], "outputs" : [ { "id" : 133353 } ] }, { "id" : 133481, "renderableClass" : "Interaction", "position" : { "x" : 2432, "y" : 2056 }, "minX" : 2209, "maxX" : 2656, "minY" : 1989, "maxY" : 2124, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2209, "y" : 1989 }, "to" : { "x" : 2656, "y" : 2124 } } ], "endShape" : { "a" : { "x" : 2648, "y" : 2126 }, "b" : { "x" : 2656, "y" : 2124 }, "c" : { "x" : 2651, "y" : 2118 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2651, "y" : 2118 } }, "reactionShape" : { "a" : { "x" : 2426, "y" : 2050 }, "b" : { "x" : 2438, "y" : 2062 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2432, "y" : 2056 } }, "inputs" : [ { "id" : 133078 } ], "outputs" : [ { "id" : 133354 } ] }, { "id" : 133486, "renderableClass" : "Interaction", "position" : { "x" : 3289, "y" : 2062 }, "minX" : 2795, "maxX" : 3444, "minY" : 1987, "maxY" : 2135, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3444, "y" : 1987 }, "to" : { "x" : 3289, "y" : 2062 } }, { "from" : { "x" : 3289, "y" : 2062 }, "to" : { "x" : 2795, "y" : 2135 } } ], "endShape" : { "a" : { "x" : 2801, "y" : 2130 }, "b" : { "x" : 2795, "y" : 2135 }, "c" : { "x" : 2802, "y" : 2138 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2802, "y" : 2138 } }, "reactionShape" : { "a" : { "x" : 3283, "y" : 2056 }, "b" : { "x" : 3295, "y" : 2068 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3289, "y" : 2062 } }, "inputs" : [ { "id" : 133101 } ], "outputs" : [ { "id" : 133354 } ] }, { "id" : 133487, "renderableClass" : "Interaction", "position" : { "x" : 3509, "y" : 2056 }, "minX" : 2795, "maxX" : 3688, "minY" : 1984, "maxY" : 2137, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3688, "y" : 1984 }, "to" : { "x" : 3509, "y" : 2056 } }, { "from" : { "x" : 3509, "y" : 2056 }, "to" : { "x" : 2795, "y" : 2137 } } ], "endShape" : { "a" : { "x" : 2801, "y" : 2132 }, "b" : { "x" : 2795, "y" : 2137 }, "c" : { "x" : 2802, "y" : 2140 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2802, "y" : 2140 } }, "reactionShape" : { "a" : { "x" : 3503, "y" : 2050 }, "b" : { "x" : 3515, "y" : 2062 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3509, "y" : 2056 } }, "inputs" : [ { "id" : 133329 } ], "outputs" : [ { "id" : 133354 } ] }, { "id" : 133484, "renderableClass" : "Interaction", "position" : { "x" : 2756, "y" : 2075 }, "minX" : 2738, "maxX" : 2775, "minY" : 2037, "maxY" : 2113, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2775, "y" : 2037 }, "to" : { "x" : 2738, "y" : 2113 } } ], "endShape" : { "a" : { "x" : 2737, "y" : 2105 }, "b" : { "x" : 2738, "y" : 2113 }, "c" : { "x" : 2745, "y" : 2109 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2745, "y" : 2109 } }, "reactionShape" : { "a" : { "x" : 2750, "y" : 2069 }, "b" : { "x" : 2762, "y" : 2081 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2756, "y" : 2075 } }, "inputs" : [ { "id" : 133089 } ], "outputs" : [ { "id" : 133354 } ] }, { "id" : 133485, "renderableClass" : "Interaction", "position" : { "x" : 3118, "y" : 2072 }, "minX" : 2795, "maxX" : 3214, "minY" : 1986, "maxY" : 2132, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3214, "y" : 1986 }, "to" : { "x" : 3118, "y" : 2072 } }, { "from" : { "x" : 3118, "y" : 2072 }, "to" : { "x" : 2795, "y" : 2132 } } ], "endShape" : { "a" : { "x" : 2801, "y" : 2127 }, "b" : { "x" : 2795, "y" : 2132 }, "c" : { "x" : 2803, "y" : 2135 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2803, "y" : 2135 } }, "reactionShape" : { "a" : { "x" : 3112, "y" : 2066 }, "b" : { "x" : 3124, "y" : 2078 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3118, "y" : 2072 } }, "inputs" : [ { "id" : 133097 } ], "outputs" : [ { "id" : 133354 } ] }, { "id" : 133490, "renderableClass" : "Interaction", "position" : { "x" : 1178, "y" : 2031 }, "minX" : 1151, "maxX" : 1206, "minY" : 1991, "maxY" : 2071, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1206, "y" : 1991 }, "to" : { "x" : 1151, "y" : 2071 } } ], "endShape" : { "a" : { "x" : 1152, "y" : 2063 }, "b" : { "x" : 1151, "y" : 2071 }, "c" : { "x" : 1158, "y" : 2068 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1158, "y" : 2068 } }, "reactionShape" : { "a" : { "x" : 1172, "y" : 2025 }, "b" : { "x" : 1184, "y" : 2037 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1178, "y" : 2031 } }, "inputs" : [ { "id" : 133145 } ], "outputs" : [ { "id" : 133353 } ] }, { "id" : 133491, "renderableClass" : "Interaction", "position" : { "x" : 1337, "y" : 2036 }, "minX" : 1191, "maxX" : 1484, "minY" : 1986, "maxY" : 2086, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1484, "y" : 1986 }, "to" : { "x" : 1191, "y" : 2086 } } ], "endShape" : { "a" : { "x" : 1196, "y" : 2080 }, "b" : { "x" : 1191, "y" : 2086 }, "c" : { "x" : 1199, "y" : 2088 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1199, "y" : 2088 } }, "reactionShape" : { "a" : { "x" : 1331, "y" : 2030 }, "b" : { "x" : 1343, "y" : 2042 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1337, "y" : 2036 } }, "inputs" : [ { "id" : 133141 } ], "outputs" : [ { "id" : 133353 } ] }, { "id" : 133488, "renderableClass" : "Interaction", "position" : { "x" : 2777, "y" : 2192 }, "minX" : 2758, "maxX" : 2797, "minY" : 2177, "maxY" : 2208, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2797, "y" : 2208 }, "to" : { "x" : 2758, "y" : 2177 } } ], "endShape" : { "a" : { "x" : 2766, "y" : 2178 }, "b" : { "x" : 2758, "y" : 2177 }, "c" : { "x" : 2761, "y" : 2184 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2761, "y" : 2184 } }, "reactionShape" : { "a" : { "x" : 2771, "y" : 2186 }, "b" : { "x" : 2783, "y" : 2198 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2777, "y" : 2192 } }, "inputs" : [ { "id" : 133105 } ], "outputs" : [ { "id" : 133354 } ] }, { "id" : 133489, "renderableClass" : "Interaction", "position" : { "x" : 1034, "y" : 2030 }, "minX" : 981, "maxX" : 1088, "minY" : 1990, "maxY" : 2071, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 981, "y" : 1990 }, "to" : { "x" : 1088, "y" : 2071 } } ], "endShape" : { "a" : { "x" : 1080, "y" : 2070 }, "b" : { "x" : 1088, "y" : 2071 }, "c" : { "x" : 1085, "y" : 2064 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1085, "y" : 2064 } }, "reactionShape" : { "a" : { "x" : 1028, "y" : 2024 }, "b" : { "x" : 1040, "y" : 2036 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1034, "y" : 2030 } }, "inputs" : [ { "id" : 133109 } ], "outputs" : [ { "id" : 133353 } ] }, { "id" : 133494, "renderableClass" : "Interaction", "position" : { "x" : 2651, "y" : 2193 }, "minX" : 2624, "maxX" : 2679, "minY" : 2177, "maxY" : 2210, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2624, "y" : 2210 }, "to" : { "x" : 2679, "y" : 2177 } } ], "endShape" : { "a" : { "x" : 2675, "y" : 2184 }, "b" : { "x" : 2679, "y" : 2177 }, "c" : { "x" : 2671, "y" : 2177 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2671, "y" : 2177 } }, "reactionShape" : { "a" : { "x" : 2645, "y" : 2187 }, "b" : { "x" : 2657, "y" : 2199 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2651, "y" : 2193 } }, "inputs" : [ { "id" : 133332 } ], "outputs" : [ { "id" : 133354 } ] }, { "id" : 133495, "renderableClass" : "Interaction", "position" : { "x" : 1075, "y" : 2176 }, "minX" : 1047, "maxX" : 1104, "minY" : 2141, "maxY" : 2212, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1047, "y" : 2212 }, "to" : { "x" : 1104, "y" : 2141 } } ], "endShape" : { "a" : { "x" : 1103, "y" : 2149 }, "b" : { "x" : 1104, "y" : 2141 }, "c" : { "x" : 1097, "y" : 2144 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1097, "y" : 2144 } }, "reactionShape" : { "a" : { "x" : 1069, "y" : 2170 }, "b" : { "x" : 1081, "y" : 2182 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1075, "y" : 2176 } }, "inputs" : [ { "id" : 133129 } ], "outputs" : [ { "id" : 133353 } ] }, { "id" : 133492, "renderableClass" : "Interaction", "position" : { "x" : 1630, "y" : 2036 }, "minX" : 1191, "maxX" : 1768, "minY" : 1988, "maxY" : 2097, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1768, "y" : 1988 }, "to" : { "x" : 1630, "y" : 2036 } }, { "from" : { "x" : 1630, "y" : 2036 }, "to" : { "x" : 1191, "y" : 2097 } } ], "endShape" : { "a" : { "x" : 1197, "y" : 2092 }, "b" : { "x" : 1191, "y" : 2097 }, "c" : { "x" : 1198, "y" : 2100 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1198, "y" : 2100 } }, "reactionShape" : { "a" : { "x" : 1624, "y" : 2030 }, "b" : { "x" : 1636, "y" : 2042 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1630, "y" : 2036 } }, "inputs" : [ { "id" : 133186 } ], "outputs" : [ { "id" : 133353 } ] }, { "id" : 133493, "renderableClass" : "Interaction", "position" : { "x" : 2872, "y" : 2111 }, "minX" : 2795, "maxX" : 2968, "minY" : 1986, "maxY" : 2129, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2968, "y" : 1986 }, "to" : { "x" : 2872, "y" : 2111 } }, { "from" : { "x" : 2872, "y" : 2111 }, "to" : { "x" : 2795, "y" : 2129 } } ], "endShape" : { "a" : { "x" : 2801, "y" : 2124 }, "b" : { "x" : 2795, "y" : 2129 }, "c" : { "x" : 2803, "y" : 2131 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2803, "y" : 2131 } }, "reactionShape" : { "a" : { "x" : 2866, "y" : 2105 }, "b" : { "x" : 2878, "y" : 2117 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2872, "y" : 2111 } }, "inputs" : [ { "id" : 133093 } ], "outputs" : [ { "id" : 133354 } ] }, { "id" : 133498, "renderableClass" : "Interaction", "position" : { "x" : 1510, "y" : 2145 }, "minX" : 1366, "maxX" : 2656, "minY" : 2139, "maxY" : 2212, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1366, "y" : 2212 }, "to" : { "x" : 1510, "y" : 2145 } }, { "from" : { "x" : 1510, "y" : 2145 }, "to" : { "x" : 2656, "y" : 2145 } } ], "endShape" : { "a" : { "x" : 2649, "y" : 2149 }, "b" : { "x" : 2656, "y" : 2145 }, "c" : { "x" : 2649, "y" : 2141 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2649, "y" : 2141 } }, "reactionShape" : { "a" : { "x" : 1504, "y" : 2139 }, "b" : { "x" : 1516, "y" : 2151 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1510, "y" : 2145 } }, "inputs" : [ { "id" : 133133 } ], "outputs" : [ { "id" : 133354 } ] }, { "id" : 133499, "renderableClass" : "Interaction", "position" : { "x" : 1516, "y" : 2096 }, "minX" : 1191, "maxX" : 1580, "minY" : 2090, "maxY" : 2218, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1580, "y" : 2218 }, "to" : { "x" : 1516, "y" : 2096 } }, { "from" : { "x" : 1516, "y" : 2096 }, "to" : { "x" : 1191, "y" : 2104 } } ], "endShape" : { "a" : { "x" : 1198, "y" : 2100 }, "b" : { "x" : 1191, "y" : 2104 }, "c" : { "x" : 1198, "y" : 2108 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1198, "y" : 2108 } }, "reactionShape" : { "a" : { "x" : 1510, "y" : 2090 }, "b" : { "x" : 1522, "y" : 2102 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1516, "y" : 2096 } }, "inputs" : [ { "id" : 133137 } ], "outputs" : [ { "id" : 133353 } ] }, { "id" : 133496, "renderableClass" : "Interaction", "position" : { "x" : 1332, "y" : 2132 }, "minX" : 1087, "maxX" : 2656, "minY" : 2126, "maxY" : 2212, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1087, "y" : 2212 }, "to" : { "x" : 1332, "y" : 2132 } }, { "from" : { "x" : 1332, "y" : 2132 }, "to" : { "x" : 2656, "y" : 2144 } } ], "endShape" : { "a" : { "x" : 2649, "y" : 2148 }, "b" : { "x" : 2656, "y" : 2144 }, "c" : { "x" : 2649, "y" : 2140 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2649, "y" : 2140 } }, "reactionShape" : { "a" : { "x" : 1326, "y" : 2126 }, "b" : { "x" : 1338, "y" : 2138 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1332, "y" : 2132 } }, "inputs" : [ { "id" : 133129 } ], "outputs" : [ { "id" : 133354 } ] }, { "id" : 133497, "renderableClass" : "Interaction", "position" : { "x" : 1239, "y" : 2176 }, "minX" : 1180, "maxX" : 1298, "minY" : 2141, "maxY" : 2212, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1298, "y" : 2212 }, "to" : { "x" : 1180, "y" : 2141 } } ], "endShape" : { "a" : { "x" : 1188, "y" : 2141 }, "b" : { "x" : 1180, "y" : 2141 }, "c" : { "x" : 1184, "y" : 2148 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1184, "y" : 2148 } }, "reactionShape" : { "a" : { "x" : 1233, "y" : 2170 }, "b" : { "x" : 1245, "y" : 2182 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1239, "y" : 2176 } }, "inputs" : [ { "id" : 133133 } ], "outputs" : [ { "id" : 133353 } ] }, { "id" : 133502, "renderableClass" : "Interaction", "position" : { "x" : 534, "y" : 2145 }, "minX" : 498, "maxX" : 1070, "minY" : 2109, "maxY" : 2214, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 498, "y" : 2214 }, "to" : { "x" : 534, "y" : 2145 } }, { "from" : { "x" : 534, "y" : 2145 }, "to" : { "x" : 1070, "y" : 2109 } } ], "endShape" : { "a" : { "x" : 1063, "y" : 2113 }, "b" : { "x" : 1070, "y" : 2109 }, "c" : { "x" : 1063, "y" : 2105 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1063, "y" : 2105 } }, "reactionShape" : { "a" : { "x" : 528, "y" : 2139 }, "b" : { "x" : 540, "y" : 2151 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 534, "y" : 2145 } }, "inputs" : [ { "id" : 133209 } ], "outputs" : [ { "id" : 133353 } ] }, { "id" : 133503, "renderableClass" : "Interaction", "position" : { "x" : 2991, "y" : 2127 }, "minX" : 2795, "maxX" : 3197, "minY" : 2121, "maxY" : 2210, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3197, "y" : 2210 }, "to" : { "x" : 2991, "y" : 2127 } }, { "from" : { "x" : 2991, "y" : 2127 }, "to" : { "x" : 2795, "y" : 2140 } } ], "endShape" : { "a" : { "x" : 2802, "y" : 2136 }, "b" : { "x" : 2795, "y" : 2140 }, "c" : { "x" : 2802, "y" : 2144 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2802, "y" : 2144 } }, "reactionShape" : { "a" : { "x" : 2985, "y" : 2121 }, "b" : { "x" : 2997, "y" : 2133 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2991, "y" : 2127 } }, "inputs" : [ { "id" : 133117 } ], "outputs" : [ { "id" : 133354 } ] }, { "id" : 133500, "renderableClass" : "Interaction", "position" : { "x" : 1694, "y" : 2155 }, "minX" : 1606, "maxX" : 2656, "minY" : 2145, "maxY" : 2218, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1606, "y" : 2218 }, "to" : { "x" : 1694, "y" : 2155 } }, { "from" : { "x" : 1694, "y" : 2155 }, "to" : { "x" : 2656, "y" : 2145 } } ], "endShape" : { "a" : { "x" : 2649, "y" : 2149 }, "b" : { "x" : 2656, "y" : 2145 }, "c" : { "x" : 2649, "y" : 2141 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2649, "y" : 2141 } }, "reactionShape" : { "a" : { "x" : 1688, "y" : 2149 }, "b" : { "x" : 1700, "y" : 2161 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1694, "y" : 2155 } }, "inputs" : [ { "id" : 133137 } ], "outputs" : [ { "id" : 133354 } ] }, { "id" : 133501, "renderableClass" : "Interaction", "position" : { "x" : 383, "y" : 2124 }, "minX" : 293, "maxX" : 1070, "minY" : 2107, "maxY" : 2212, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 293, "y" : 2212 }, "to" : { "x" : 383, "y" : 2124 } }, { "from" : { "x" : 383, "y" : 2124 }, "to" : { "x" : 1070, "y" : 2107 } } ], "endShape" : { "a" : { "x" : 1063, "y" : 2111 }, "b" : { "x" : 1070, "y" : 2107 }, "c" : { "x" : 1063, "y" : 2103 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1063, "y" : 2103 } }, "reactionShape" : { "a" : { "x" : 377, "y" : 2118 }, "b" : { "x" : 389, "y" : 2130 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 383, "y" : 2124 } }, "inputs" : [ { "id" : 133165 } ], "outputs" : [ { "id" : 133353 } ] }, { "id" : 133506, "renderableClass" : "Interaction", "position" : { "x" : 1688, "y" : 2074 }, "minX" : 1191, "maxX" : 1797, "minY" : 2068, "maxY" : 2213, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1797, "y" : 2213 }, "to" : { "x" : 1688, "y" : 2074 } }, { "from" : { "x" : 1688, "y" : 2074 }, "to" : { "x" : 1191, "y" : 2102 } } ], "endShape" : { "a" : { "x" : 1198, "y" : 2098 }, "b" : { "x" : 1191, "y" : 2102 }, "c" : { "x" : 1198, "y" : 2106 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1198, "y" : 2106 } }, "reactionShape" : { "a" : { "x" : 1682, "y" : 2068 }, "b" : { "x" : 1694, "y" : 2080 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1688, "y" : 2074 } }, "inputs" : [ { "id" : 133153 } ], "outputs" : [ { "id" : 133353 } ] }, { "id" : 133507, "renderableClass" : "Interaction", "position" : { "x" : 1898, "y" : 2043 }, "minX" : 1191, "maxX" : 2151, "minY" : 2037, "maxY" : 2214, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2151, "y" : 2214 }, "to" : { "x" : 1898, "y" : 2043 } }, { "from" : { "x" : 1898, "y" : 2043 }, "to" : { "x" : 1191, "y" : 2101 } } ], "endShape" : { "a" : { "x" : 1198, "y" : 2096 }, "b" : { "x" : 1191, "y" : 2101 }, "c" : { "x" : 1198, "y" : 2104 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1198, "y" : 2104 } }, "reactionShape" : { "a" : { "x" : 1892, "y" : 2037 }, "b" : { "x" : 1904, "y" : 2049 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1898, "y" : 2043 } }, "inputs" : [ { "id" : 133157 } ], "outputs" : [ { "id" : 133353 } ] }, { "id" : 133504, "renderableClass" : "Interaction", "position" : { "x" : 3238, "y" : 2197 }, "minX" : 3232, "maxX" : 3244, "minY" : 2188, "maxY" : 2206, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3238, "y" : 2206 }, "to" : { "x" : 3238, "y" : 2188 } } ], "endShape" : { "a" : { "x" : 3242, "y" : 2195 }, "b" : { "x" : 3238, "y" : 2188 }, "c" : { "x" : 3234, "y" : 2195 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3234, "y" : 2195 } }, "reactionShape" : { "a" : { "x" : 3232, "y" : 2191 }, "b" : { "x" : 3244, "y" : 2203 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3238, "y" : 2197 } }, "inputs" : [ { "id" : 133117 } ], "outputs" : [ { "id" : 133355 } ] }, { "id" : 133505, "renderableClass" : "Interaction", "position" : { "x" : 775, "y" : 2147 }, "minX" : 742, "maxX" : 1070, "minY" : 2112, "maxY" : 2219, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 742, "y" : 2219 }, "to" : { "x" : 775, "y" : 2147 } }, { "from" : { "x" : 775, "y" : 2147 }, "to" : { "x" : 1070, "y" : 2112 } } ], "endShape" : { "a" : { "x" : 1064, "y" : 2117 }, "b" : { "x" : 1070, "y" : 2112 }, "c" : { "x" : 1063, "y" : 2109 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1063, "y" : 2109 } }, "reactionShape" : { "a" : { "x" : 769, "y" : 2141 }, "b" : { "x" : 781, "y" : 2153 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 775, "y" : 2147 } }, "inputs" : [ { "id" : 133121 } ], "outputs" : [ { "id" : 133353 } ] }, { "id" : 133510, "renderableClass" : "Interaction", "position" : { "x" : 708, "y" : 150 }, "minX" : 644, "maxX" : 772, "minY" : 104, "maxY" : 197, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 644, "y" : 104 }, "to" : { "x" : 772, "y" : 197 } } ], "endShape" : { "a" : { "x" : 764, "y" : 196 }, "b" : { "x" : 772, "y" : 197 }, "c" : { "x" : 769, "y" : 190 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 769, "y" : 190 } }, "reactionShape" : { "a" : { "x" : 702, "y" : 144 }, "b" : { "x" : 714, "y" : 156 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 708, "y" : 150 } }, "inputs" : [ { "id" : 133217 } ], "outputs" : [ { "id" : 133340 } ] }, { "id" : 133511, "renderableClass" : "Interaction", "position" : { "x" : 1081, "y" : 217 }, "minX" : 664, "maxX" : 2505, "minY" : 94, "maxY" : 223, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 664, "y" : 94 }, "to" : { "x" : 1081, "y" : 217 } }, { "from" : { "x" : 1081, "y" : 217 }, "to" : { "x" : 2505, "y" : 214 } } ], "endShape" : { "a" : { "x" : 2498, "y" : 218 }, "b" : { "x" : 2505, "y" : 214 }, "c" : { "x" : 2498, "y" : 210 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2498, "y" : 210 } }, "reactionShape" : { "a" : { "x" : 1075, "y" : 211 }, "b" : { "x" : 1087, "y" : 223 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1081, "y" : 217 } }, "inputs" : [ { "id" : 133217 } ], "outputs" : [ { "id" : 133339 } ] }, { "id" : 133508, "renderableClass" : "Interaction", "position" : { "x" : 3726, "y" : 1358 }, "minX" : 3127, "maxX" : 4010, "minY" : 1335, "maxY" : 1549, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 4010, "y" : 1549 }, "to" : { "x" : 3726, "y" : 1358 } }, { "from" : { "x" : 3726, "y" : 1358 }, "to" : { "x" : 3127, "y" : 1335 } } ], "endShape" : { "a" : { "x" : 3134, "y" : 1331 }, "b" : { "x" : 3127, "y" : 1335 }, "c" : { "x" : 3134, "y" : 1339 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3134, "y" : 1339 } }, "reactionShape" : { "a" : { "x" : 3720, "y" : 1352 }, "b" : { "x" : 3732, "y" : 1364 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3726, "y" : 1358 } }, "inputs" : [ { "id" : 133223 } ], "outputs" : [ { "id" : 133350 } ] }, { "id" : 133509, "renderableClass" : "Interaction", "position" : { "x" : 3655, "y" : 1262 }, "minX" : 3127, "maxX" : 3997, "minY" : 1175, "maxY" : 1324, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3997, "y" : 1175 }, "to" : { "x" : 3655, "y" : 1262 } }, { "from" : { "x" : 3655, "y" : 1262 }, "to" : { "x" : 3127, "y" : 1324 } } ], "endShape" : { "a" : { "x" : 3133, "y" : 1319 }, "b" : { "x" : 3127, "y" : 1324 }, "c" : { "x" : 3134, "y" : 1327 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3134, "y" : 1327 } }, "reactionShape" : { "a" : { "x" : 3649, "y" : 1256 }, "b" : { "x" : 3661, "y" : 1268 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3655, "y" : 1262 } }, "inputs" : [ { "id" : 133226 } ], "outputs" : [ { "id" : 133350 } ] }, { "id" : 133514, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 277, "y" : 2498 }, "minX" : 216, "maxX" : 338, "minY" : 2486, "maxY" : 2510, "segments" : [ { "from" : { "x" : 338, "y" : 2486 }, "to" : { "x" : 216, "y" : 2510 } } ], "reactionShape" : { "a" : { "x" : 271, "y" : 2492 }, "b" : { "x" : 283, "y" : 2504 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 277, "y" : 2498 } }, "inputs" : [ { "id" : 133254 } ], "outputs" : [ { "id" : 132807 } ] }, { "id" : 133515, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 491, "y" : 2595 }, "minX" : 239, "maxX" : 744, "minY" : 2500, "maxY" : 2690, "segments" : [ { "from" : { "x" : 239, "y" : 2690 }, "to" : { "x" : 744, "y" : 2500 } } ], "reactionShape" : { "a" : { "x" : 485, "y" : 2589 }, "b" : { "x" : 497, "y" : 2601 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 491, "y" : 2595 } }, "inputs" : [ { "id" : 132812 } ], "outputs" : [ { "id" : 133257 } ] }, { "id" : 133512, "renderableClass" : "Interaction", "position" : { "x" : 489, "y" : 2584 }, "minX" : 228, "maxX" : 750, "minY" : 2568, "maxY" : 2601, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 228, "y" : 2601 }, "to" : { "x" : 750, "y" : 2568 } } ], "endShape" : { "a" : { "x" : 743, "y" : 2572 }, "b" : { "x" : 750, "y" : 2568 }, "c" : { "x" : 743, "y" : 2564 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 743, "y" : 2564 } }, "reactionShape" : { "a" : { "x" : 483, "y" : 2578 }, "b" : { "x" : 495, "y" : 2590 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 489, "y" : 2584 } }, "inputs" : [ { "id" : 132809 } ], "outputs" : [ { "id" : 133357 } ] }, { "id" : 133513, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 296, "y" : 2589 }, "minX" : 223, "maxX" : 369, "minY" : 2497, "maxY" : 2682, "segments" : [ { "from" : { "x" : 223, "y" : 2682 }, "to" : { "x" : 369, "y" : 2497 } } ], "reactionShape" : { "a" : { "x" : 290, "y" : 2583 }, "b" : { "x" : 302, "y" : 2595 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 296, "y" : 2589 } }, "inputs" : [ { "id" : 132812 } ], "outputs" : [ { "id" : 133254 } ] }, { "id" : 133518, "renderableClass" : "Interaction", "position" : { "x" : 1028, "y" : 2518 }, "minX" : 902, "maxX" : 1079, "minY" : 2502, "maxY" : 2547, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1079, "y" : 2502 }, "to" : { "x" : 1028, "y" : 2518 } }, { "from" : { "x" : 1028, "y" : 2518 }, "to" : { "x" : 902, "y" : 2547 } } ], "endShape" : { "a" : { "x" : 908, "y" : 2542 }, "b" : { "x" : 902, "y" : 2547 }, "c" : { "x" : 910, "y" : 2549 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 910, "y" : 2549 } }, "reactionShape" : { "a" : { "x" : 1022, "y" : 2512 }, "b" : { "x" : 1034, "y" : 2524 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1028, "y" : 2518 } }, "inputs" : [ { "id" : 133262 } ], "outputs" : [ { "id" : 133357 } ] }, { "id" : 133519, "renderableClass" : "Interaction", "position" : { "x" : 925, "y" : 2514 }, "minX" : 886, "maxX" : 965, "minY" : 2497, "maxY" : 2532, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 965, "y" : 2497 }, "to" : { "x" : 886, "y" : 2532 } } ], "endShape" : { "a" : { "x" : 891, "y" : 2526 }, "b" : { "x" : 886, "y" : 2532 }, "c" : { "x" : 894, "y" : 2533 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 894, "y" : 2533 } }, "reactionShape" : { "a" : { "x" : 919, "y" : 2508 }, "b" : { "x" : 931, "y" : 2520 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 925, "y" : 2514 } }, "inputs" : [ { "id" : 133007 } ], "outputs" : [ { "id" : 133357 } ] }, { "id" : 133516, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 572, "y" : 2481 }, "minX" : 418, "maxX" : 726, "minY" : 2475, "maxY" : 2487, "segments" : [ { "from" : { "x" : 726, "y" : 2482 }, "to" : { "x" : 418, "y" : 2480 } } ], "reactionShape" : { "a" : { "x" : 566, "y" : 2475 }, "b" : { "x" : 578, "y" : 2487 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 572, "y" : 2481 } }, "inputs" : [ { "id" : 133257 } ], "outputs" : [ { "id" : 133254 } ] }, { "id" : 133517, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 471, "y" : 2500 }, "minX" : 216, "maxX" : 726, "minY" : 2485, "maxY" : 2515, "segments" : [ { "from" : { "x" : 726, "y" : 2485 }, "to" : { "x" : 216, "y" : 2515 } } ], "reactionShape" : { "a" : { "x" : 465, "y" : 2494 }, "b" : { "x" : 477, "y" : 2506 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 471, "y" : 2500 } }, "inputs" : [ { "id" : 133257 } ], "outputs" : [ { "id" : 132807 } ] }, { "id" : 133522, "renderableClass" : "Interaction", "position" : { "x" : 2602, "y" : 2526 }, "minX" : 2551, "maxX" : 2653, "minY" : 2494, "maxY" : 2558, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2551, "y" : 2494 }, "to" : { "x" : 2653, "y" : 2558 } } ], "endShape" : { "a" : { "x" : 2645, "y" : 2558 }, "b" : { "x" : 2653, "y" : 2558 }, "c" : { "x" : 2649, "y" : 2551 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2649, "y" : 2551 } }, "reactionShape" : { "a" : { "x" : 2596, "y" : 2520 }, "b" : { "x" : 2608, "y" : 2532 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2602, "y" : 2526 } }, "inputs" : [ { "id" : 133285 } ], "outputs" : [ { "id" : 133358 } ] }, { "id" : 133523, "renderableClass" : "Interaction", "position" : { "x" : 2632, "y" : 2656 }, "minX" : 2598, "maxX" : 2666, "minY" : 2628, "maxY" : 2685, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2598, "y" : 2685 }, "to" : { "x" : 2666, "y" : 2628 } } ], "endShape" : { "a" : { "x" : 2663, "y" : 2636 }, "b" : { "x" : 2666, "y" : 2628 }, "c" : { "x" : 2658, "y" : 2629 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2658, "y" : 2629 } }, "reactionShape" : { "a" : { "x" : 2626, "y" : 2650 }, "b" : { "x" : 2638, "y" : 2662 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2632, "y" : 2656 } }, "inputs" : [ { "id" : 133278 } ], "outputs" : [ { "id" : 133358 } ] }, { "id" : 133520, "renderableClass" : "Interaction", "position" : { "x" : 2829, "y" : 2653 }, "minX" : 2764, "maxX" : 2895, "minY" : 2620, "maxY" : 2686, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2895, "y" : 2686 }, "to" : { "x" : 2764, "y" : 2620 } } ], "endShape" : { "a" : { "x" : 2772, "y" : 2620 }, "b" : { "x" : 2764, "y" : 2620 }, "c" : { "x" : 2768, "y" : 2627 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2768, "y" : 2627 } }, "reactionShape" : { "a" : { "x" : 2823, "y" : 2647 }, "b" : { "x" : 2835, "y" : 2659 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2829, "y" : 2653 } }, "inputs" : [ { "id" : 133269 } ], "outputs" : [ { "id" : 133358 } ] }, { "id" : 133526, "renderableClass" : "Interaction", "position" : { "x" : 560, "y" : 2669 }, "minX" : 547, "maxX" : 574, "minY" : 2657, "maxY" : 2682, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 547, "y" : 2682 }, "to" : { "x" : 574, "y" : 2657 } } ], "endShape" : { "a" : { "x" : 572, "y" : 2665 }, "b" : { "x" : 574, "y" : 2657 }, "c" : { "x" : 566, "y" : 2659 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 566, "y" : 2659 } }, "reactionShape" : { "a" : { "x" : 554, "y" : 2663 }, "b" : { "x" : 566, "y" : 2675 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 560, "y" : 2669 } }, "inputs" : [ { "id" : 132936 } ], "outputs" : [ { "id" : 133341 } ] }, { "id" : 133527, "renderableClass" : "Interaction", "position" : { "x" : 3109, "y" : 2567 }, "minX" : 2764, "maxX" : 3286, "minY" : 2493, "maxY" : 2589, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3286, "y" : 2493 }, "to" : { "x" : 3109, "y" : 2567 } }, { "from" : { "x" : 3109, "y" : 2567 }, "to" : { "x" : 2764, "y" : 2589 } } ], "endShape" : { "a" : { "x" : 2771, "y" : 2585 }, "b" : { "x" : 2764, "y" : 2589 }, "c" : { "x" : 2771, "y" : 2593 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2771, "y" : 2593 } }, "reactionShape" : { "a" : { "x" : 3103, "y" : 2561 }, "b" : { "x" : 3115, "y" : 2573 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3109, "y" : 2567 } }, "inputs" : [ { "id" : 133066 } ], "outputs" : [ { "id" : 133358 } ] }, { "id" : 133524, "renderableClass" : "Interaction", "position" : { "x" : 2698, "y" : 2657 }, "minX" : 2692, "maxX" : 2704, "minY" : 2628, "maxY" : 2686, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2697, "y" : 2686 }, "to" : { "x" : 2700, "y" : 2628 } } ], "endShape" : { "a" : { "x" : 2704, "y" : 2635 }, "b" : { "x" : 2700, "y" : 2628 }, "c" : { "x" : 2696, "y" : 2635 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2696, "y" : 2635 } }, "reactionShape" : { "a" : { "x" : 2692, "y" : 2651 }, "b" : { "x" : 2704, "y" : 2663 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2698, "y" : 2657 } }, "inputs" : [ { "id" : 132940 } ], "outputs" : [ { "id" : 133358 } ] }, { "id" : 133525, "renderableClass" : "Interaction", "position" : { "x" : 2925, "y" : 2795 }, "minX" : 2909, "maxX" : 2942, "minY" : 2789, "maxY" : 2801, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2909, "y" : 2795 }, "to" : { "x" : 2942, "y" : 2795 } } ], "endShape" : { "a" : { "x" : 2935, "y" : 2799 }, "b" : { "x" : 2942, "y" : 2795 }, "c" : { "x" : 2935, "y" : 2791 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2935, "y" : 2791 } }, "reactionShape" : { "a" : { "x" : 2919, "y" : 2789 }, "b" : { "x" : 2931, "y" : 2801 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2925, "y" : 2795 } }, "inputs" : [ { "id" : 133359 } ], "outputs" : [ { "id" : 133268 } ] }, { "id" : 133530, "renderableClass" : "Interaction", "position" : { "x" : 3146, "y" : 2652 }, "minX" : 2764, "maxX" : 3210, "minY" : 2600, "maxY" : 2686, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3210, "y" : 2686 }, "to" : { "x" : 3146, "y" : 2652 } }, { "from" : { "x" : 3146, "y" : 2652 }, "to" : { "x" : 2764, "y" : 2600 } } ], "endShape" : { "a" : { "x" : 2771, "y" : 2597 }, "b" : { "x" : 2764, "y" : 2600 }, "c" : { "x" : 2770, "y" : 2605 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2770, "y" : 2605 } }, "reactionShape" : { "a" : { "x" : 3140, "y" : 2646 }, "b" : { "x" : 3152, "y" : 2658 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3146, "y" : 2652 } }, "inputs" : [ { "id" : 132905 } ], "outputs" : [ { "id" : 133358 } ] }, { "id" : 133531, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 3395, "y" : 2702 }, "minX" : 3374, "maxX" : 3417, "minY" : 2696, "maxY" : 2708, "segments" : [ { "from" : { "x" : 3417, "y" : 2702 }, "to" : { "x" : 3374, "y" : 2702 } } ], "reactionShape" : { "a" : { "x" : 3389, "y" : 2696 }, "b" : { "x" : 3401, "y" : 2708 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3395, "y" : 2702 } }, "inputs" : [ { "id" : 133300 } ], "outputs" : [ { "id" : 132903 } ] }, { "id" : 133528, "renderableClass" : "Interaction", "position" : { "x" : 487, "y" : 2673 }, "minX" : 443, "maxX" : 532, "minY" : 2657, "maxY" : 2689, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 443, "y" : 2689 }, "to" : { "x" : 532, "y" : 2657 } } ], "endShape" : { "a" : { "x" : 527, "y" : 2663 }, "b" : { "x" : 532, "y" : 2657 }, "c" : { "x" : 524, "y" : 2656 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 524, "y" : 2656 } }, "reactionShape" : { "a" : { "x" : 481, "y" : 2667 }, "b" : { "x" : 493, "y" : 2679 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 487, "y" : 2673 } }, "inputs" : [ { "id" : 132813 } ], "outputs" : [ { "id" : 133341 } ] }, { "id" : 133529, "renderableClass" : "Interaction", "position" : { "x" : 872, "y" : 2639 }, "minX" : 844, "maxX" : 900, "minY" : 2596, "maxY" : 2682, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 900, "y" : 2682 }, "to" : { "x" : 844, "y" : 2596 } } ], "endShape" : { "a" : { "x" : 851, "y" : 2600 }, "b" : { "x" : 844, "y" : 2596 }, "c" : { "x" : 844, "y" : 2604 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 844, "y" : 2604 } }, "reactionShape" : { "a" : { "x" : 866, "y" : 2633 }, "b" : { "x" : 878, "y" : 2645 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 872, "y" : 2639 } }, "inputs" : [ { "id" : 132909 } ], "outputs" : [ { "id" : 133357 } ] }, { "id" : 133533, "renderableClass" : "Interaction", "position" : { "x" : 1673, "y" : 2529 }, "minX" : 902, "maxX" : 1689, "minY" : 2503, "maxY" : 2560, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1689, "y" : 2503 }, "to" : { "x" : 1673, "y" : 2529 } }, { "from" : { "x" : 1673, "y" : 2529 }, "to" : { "x" : 902, "y" : 2560 } } ], "endShape" : { "a" : { "x" : 909, "y" : 2556 }, "b" : { "x" : 902, "y" : 2560 }, "c" : { "x" : 909, "y" : 2564 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 909, "y" : 2564 } }, "reactionShape" : { "a" : { "x" : 1667, "y" : 2523 }, "b" : { "x" : 1679, "y" : 2535 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1673, "y" : 2529 } }, "inputs" : [ { "id" : 132984 } ], "outputs" : [ { "id" : 133357 } ] }, { "id" : 133536, "renderableClass" : "Interaction", "position" : { "x" : 1843, "y" : 2577 }, "minX" : 902, "maxX" : 1970, "minY" : 2501, "maxY" : 2583, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1970, "y" : 2501 }, "to" : { "x" : 1843, "y" : 2577 } }, { "from" : { "x" : 1843, "y" : 2577 }, "to" : { "x" : 902, "y" : 2564 } } ], "endShape" : { "a" : { "x" : 909, "y" : 2560 }, "b" : { "x" : 902, "y" : 2564 }, "c" : { "x" : 909, "y" : 2568 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 909, "y" : 2568 } }, "reactionShape" : { "a" : { "x" : 1837, "y" : 2571 }, "b" : { "x" : 1849, "y" : 2583 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1843, "y" : 2577 } }, "inputs" : [ { "id" : 132825 } ], "outputs" : [ { "id" : 133357 } ] }, { "id" : 133366, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1131, "y" : 1750 }, "minX" : 587, "maxX" : 1676, "minY" : 1744, "maxY" : 1756, "segments" : [ { "from" : { "x" : 587, "y" : 1748 }, "to" : { "x" : 1676, "y" : 1752 } } ], "reactionShape" : { "a" : { "x" : 1125, "y" : 1744 }, "b" : { "x" : 1137, "y" : 1756 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1131, "y" : 1750 } }, "inputs" : [ { "id" : 133034 } ], "outputs" : [ { "id" : 133021 } ] }, { "id" : 133367, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1317, "y" : 2285 }, "minX" : 1207, "maxX" : 1417, "minY" : 2242, "maxY" : 2291, "segments" : [ { "from" : { "x" : 1417, "y" : 2246 }, "to" : { "x" : 1317, "y" : 2285 } }, { "from" : { "x" : 1317, "y" : 2285 }, "to" : { "x" : 1207, "y" : 2242 } } ], "reactionShape" : { "a" : { "x" : 1311, "y" : 2279 }, "b" : { "x" : 1323, "y" : 2291 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1317, "y" : 2285 } }, "inputs" : [ { "id" : 133135 } ], "outputs" : [ { "id" : 133132 } ] }, { "id" : 133364, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 2018, "y" : 972 }, "minX" : 435, "maxX" : 3601, "minY" : 962, "maxY" : 982, "segments" : [ { "from" : { "x" : 3601, "y" : 962 }, "to" : { "x" : 435, "y" : 982 } } ], "reactionShape" : { "a" : { "x" : 2012, "y" : 966 }, "b" : { "x" : 2024, "y" : 978 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2018, "y" : 972 } }, "inputs" : [ { "id" : 132899 } ], "outputs" : [ { "id" : 132891 } ] }, { "id" : 133365, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 2054, "y" : 1704 }, "minX" : 1753, "maxX" : 2355, "minY" : 1661, "maxY" : 1748, "segments" : [ { "from" : { "x" : 2355, "y" : 1661 }, "to" : { "x" : 1753, "y" : 1748 } } ], "reactionShape" : { "a" : { "x" : 2048, "y" : 1698 }, "b" : { "x" : 2060, "y" : 1710 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2054, "y" : 1704 } }, "inputs" : [ { "id" : 133030 } ], "outputs" : [ { "id" : 133021 } ] }, { "id" : 133370, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 487, "y" : 981 }, "minX" : 435, "maxX" : 539, "minY" : 975, "maxY" : 987, "segments" : [ { "from" : { "x" : 435, "y" : 982 }, "to" : { "x" : 539, "y" : 980 } } ], "reactionShape" : { "a" : { "x" : 481, "y" : 975 }, "b" : { "x" : 493, "y" : 987 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 487, "y" : 981 } }, "inputs" : [ { "id" : 132891 } ], "outputs" : [ { "id" : 132896 } ] }, { "id" : 133369, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 1146, "y" : 432 }, "minX" : 1059, "maxX" : 1234, "minY" : 426, "maxY" : 438, "segments" : [ { "from" : { "x" : 1234, "y" : 438 }, "to" : { "x" : 1059, "y" : 426 } } ], "reactionShape" : { "a" : { "x" : 1140, "y" : 426 }, "b" : { "x" : 1152, "y" : 438 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1146, "y" : 432 } }, "inputs" : [ { "id" : 132760 } ], "outputs" : [ { "id" : 132756 } ] }, { "id" : 133374, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1171, "y" : 224 }, "minX" : 1033, "maxX" : 1310, "minY" : 45, "maxY" : 403, "segments" : [ { "from" : { "x" : 1310, "y" : 45 }, "to" : { "x" : 1033, "y" : 403 } } ], "reactionShape" : { "a" : { "x" : 1165, "y" : 218 }, "b" : { "x" : 1177, "y" : 230 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1171, "y" : 224 } }, "inputs" : [ { "id" : 132715 } ], "outputs" : [ { "id" : 132756 } ] }, { "id" : 133375, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 945, "y" : 1900 }, "minX" : 879, "maxX" : 1012, "minY" : 1894, "maxY" : 1906, "segments" : [ { "from" : { "x" : 1012, "y" : 1902 }, "to" : { "x" : 879, "y" : 1899 } } ], "reactionShape" : { "a" : { "x" : 939, "y" : 1894 }, "b" : { "x" : 951, "y" : 1906 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 945, "y" : 1900 } }, "inputs" : [ { "id" : 133144 } ], "outputs" : [ { "id" : 133108 } ] }, { "id" : 133373, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1293, "y" : 232 }, "minX" : 1269, "maxX" : 1317, "minY" : 45, "maxY" : 419, "segments" : [ { "from" : { "x" : 1317, "y" : 45 }, "to" : { "x" : 1269, "y" : 419 } } ], "reactionShape" : { "a" : { "x" : 1287, "y" : 226 }, "b" : { "x" : 1299, "y" : 238 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1293, "y" : 232 } }, "inputs" : [ { "id" : 132715 } ], "outputs" : [ { "id" : 132760 } ] } ], "shadows" : [ { "id" : 133538, "reactomeId" : 10444456, "displayName" : "Amine ligand-binding receptors", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2180, "y" : 1870 }, "minX" : 33, "maxX" : 4327, "minY" : 881, "maxY" : 2859, "prop" : { "x" : 4057, "y" : 881, "width" : 270, "height" : 1907 }, "points" : [ { "x" : 33, "y" : 881 }, { "x" : 4327, "y" : 881 }, { "x" : 4327, "y" : 2859 }, { "x" : 33, "y" : 2859 } ], "colour" : "#dc3912" }, { "id" : 133539, "reactomeId" : 10444476, "displayName" : "Hormone ligand-binding receptors", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2696, "y" : 1966 }, "minX" : 1527, "maxX" : 3865, "minY" : 1043, "maxY" : 2890, "prop" : { "x" : 1527, "y" : 1043, "width" : 2338, "height" : 1847 }, "points" : [ { "x" : 1527, "y" : 1043 }, { "x" : 3865, "y" : 1043 }, { "x" : 3865, "y" : 2890 }, { "x" : 1527, "y" : 2890 } ], "colour" : "#008000" }, { "id" : 133537, "reactomeId" : 10444314, "displayName" : "Peptide ligand-binding receptors", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2023, "y" : 1391 }, "minX" : -10, "maxX" : 4057, "minY" : -5, "maxY" : 2788, "prop" : { "x" : -10, "y" : -5, "width" : 4067, "height" : 886 }, "points" : [ { "x" : -10, "y" : -5 }, { "x" : 4057, "y" : -5 }, { "x" : 4057, "y" : 2788 }, { "x" : -10, "y" : 2788 } ], "colour" : "#4684ee" }, { "id" : 133542, "reactomeId" : 10444556, "displayName" : "Lysosphingolipid and LPA receptors", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1832, "y" : 2332 }, "minX" : 512, "maxX" : 3152, "minY" : 1834, "maxY" : 2831, "prop" : { "x" : 512, "y" : 2788, "width" : 1015, "height" : 43 }, "points" : [ { "x" : 512, "y" : 1834 }, { "x" : 3152, "y" : 1834 }, { "x" : 3152, "y" : 2831 }, { "x" : 512, "y" : 2831 } ], "colour" : "#cb4ac5" }, { "id" : 133543, "reactomeId" : 10444560, "displayName" : "Opsins", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2639, "y" : 1955 }, "minX" : 2439, "maxX" : 2839, "minY" : 1866, "maxY" : 2044, "prop" : { "x" : 2439, "y" : 1871, "width" : 383, "height" : 127 }, "points" : [ { "x" : 2439, "y" : 1866 }, { "x" : 2839, "y" : 1866 }, { "x" : 2839, "y" : 2044 }, { "x" : 2439, "y" : 2044 } ], "colour" : "#d6ae00" }, { "id" : 133540, "reactomeId" : 10444478, "displayName" : "Eicosanoid ligand-binding receptors", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1765, "y" : 1775 }, "minX" : 167, "maxX" : 3364, "minY" : 1034, "maxY" : 2516, "prop" : { "x" : 167, "y" : 1043, "width" : 1360, "height" : 529 }, "points" : [ { "x" : 167, "y" : 1034 }, { "x" : 3364, "y" : 1034 }, { "x" : 3364, "y" : 2516 }, { "x" : 167, "y" : 2516 } ], "colour" : "#666666" }, { "id" : 133541, "reactomeId" : 10444532, "displayName" : "Nucleotide-like (purinergic) receptors", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2266, "y" : 1675 }, "minX" : 534, "maxX" : 3998, "minY" : 1572, "maxY" : 1779, "prop" : { "x" : 3865, "y" : 1572, "width" : 133, "height" : 207 }, "points" : [ { "x" : 534, "y" : 1572 }, { "x" : 3998, "y" : 1572 }, { "x" : 3998, "y" : 1779 }, { "x" : 534, "y" : 1779 } ], "colour" : "#4942cc" }, { "id" : 133544, "reactomeId" : 10444662, "displayName" : "Free fatty acid receptors", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 3423, "y" : 1934 }, "minX" : 2822, "maxX" : 4025, "minY" : 1871, "maxY" : 1998, "prop" : { "x" : 3865, "y" : 1871, "width" : 160, "height" : 127 }, "points" : [ { "x" : 2822, "y" : 1871 }, { "x" : 4025, "y" : 1871 }, { "x" : 4025, "y" : 1998 }, { "x" : 2822, "y" : 1998 } ], "colour" : "#336699" }, { "id" : 133545, "reactomeId" : 10444668, "displayName" : "Hydroxycarboxylic acid-binding receptors", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1162, "y" : 1936 }, "minX" : 754, "maxX" : 1570, "minY" : 1874, "maxY" : 1998, "prop" : { "x" : 754, "y" : 1874, "width" : 773, "height" : 124 }, "points" : [ { "x" : 754, "y" : 1874 }, { "x" : 1570, "y" : 1874 }, { "x" : 1570, "y" : 1998 }, { "x" : 754, "y" : 1998 } ], "colour" : "#dd4477" } ], "minX" : 0, "maxX" : 4317, "minY" : 0, "maxY" : 2880, "disease" : false }