{
  "dbId" : 10444298,
  "stId" : "R-BTA-354192",
  "speciesName" : "Bos taurus",
  "nodes" : [ {
    "dbId" : 377604,
    "stId" : "R-ALL-377604",
    "displayName" : "Integrin binding divalent cations [extracellular region]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 0,
    "diagramIds" : [ 83466 ],
    "parents" : [ 10357430, 10357436, 10356200, 10356158, 10357425 ],
    "children" : [ 74112, 266099, 114632 ]
  }, {
    "dbId" : 74112,
    "stId" : "R-ALL-74112",
    "displayName" : "Ca2+ [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "29108",
    "standardIdentifier" : "chebi:29108",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 377604 ],
    "children" : [ ]
  }, {
    "dbId" : 10356127,
    "stId" : "R-BTA-354118",
    "displayName" : "RAP1A [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P62833",
    "standardIdentifier" : "uniprot:P62833",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10356133 ],
    "children" : [ ]
  }, {
    "dbId" : 10337685,
    "stId" : "R-BTA-64847",
    "displayName" : "SOS1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 83495 ],
    "identifier" : "F1N7C3",
    "standardIdentifier" : "uniprot:F1N7C3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SOS1" ],
    "parents" : [ 10356204 ],
    "children" : [ ]
  }, {
    "dbId" : 10337681,
    "stId" : "R-BTA-74686",
    "displayName" : "GRB2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 83492 ],
    "identifier" : "Q3T0F9",
    "standardIdentifier" : "uniprot:Q3T0F9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GRB2" ],
    "parents" : [ 10356189 ],
    "children" : [ ]
  }, {
    "dbId" : 10341517,
    "stId" : "R-BTA-114514",
    "displayName" : "Integrin alphaIIb:beta3 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83510 ],
    "parents" : [ 10357434, 10357423, 10356148, 10356174 ],
    "children" : [ 10341511, 10341515 ]
  }, {
    "dbId" : 179856,
    "stId" : "R-ALL-179856",
    "displayName" : "PI(4,5)P2 [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 83455 ],
    "identifier" : "58456",
    "standardIdentifier" : "chebi:58456",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10356141 ],
    "children" : [ ]
  }, {
    "dbId" : 10341515,
    "stId" : "R-BTA-57600",
    "displayName" : "ITGB3 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MTN1",
    "standardIdentifier" : "uniprot:F1MTN1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ITGB3" ],
    "parents" : [ 10341517 ],
    "children" : [ ]
  }, {
    "dbId" : 10341511,
    "stId" : "R-BTA-57578",
    "displayName" : "ITGA2B(32-1039) [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MGZ4",
    "standardIdentifier" : "uniprot:F1MGZ4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10364397, 10341517 ],
    "children" : [ ]
  }, {
    "dbId" : 10356158,
    "stId" : "R-BTA-377622",
    "displayName" : "Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83481 ],
    "parents" : [ 10363875, 10363868, 10356160, 10356167, 10356187 ],
    "children" : [ 10356148, 10356154, 10356156, 377604 ]
  }, {
    "dbId" : 10357438,
    "stId" : "R-BTA-210625",
    "displayName" : "PTPN1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 83478 ],
    "identifier" : "A6QQN2",
    "standardIdentifier" : "uniprot:A6QQN2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 74016,
    "stId" : "R-ALL-74016",
    "displayName" : "Ca2+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "29108",
    "standardIdentifier" : "chebi:29108",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10356220 ],
    "children" : [ ]
  }, {
    "dbId" : 10356156,
    "stId" : "R-BTA-377603",
    "displayName" : "Integrin alphaIIb beta3 ECM ligands [extracellular region]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 83465 ],
    "parents" : [ 10357430, 10357436, 10357425, 10356158, 10356200 ],
    "children" : [ 10352830, 10341615 ]
  }, {
    "dbId" : 10356284,
    "stId" : "R-BTA-372652",
    "displayName" : "CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83506 ],
    "parents" : [ ],
    "children" : [ 10356277, 10345561 ]
  }, {
    "dbId" : 10357436,
    "stId" : "R-BTA-377616",
    "displayName" : "Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83472 ],
    "parents" : [ ],
    "children" : [ 10356154, 10357434, 10356156, 377604 ]
  }, {
    "dbId" : 10352830,
    "stId" : "R-BTA-54851",
    "displayName" : "FN1 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "G5E5A9",
    "standardIdentifier" : "uniprot:G5E5A9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FN1" ],
    "parents" : [ 10356156 ],
    "children" : [ ]
  }, {
    "dbId" : 10355517,
    "stId" : "R-BTA-3008670",
    "displayName" : "RAPGEF3 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1ME49",
    "standardIdentifier" : "uniprot:F1ME49",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RAPGEF3" ],
    "parents" : [ 10361208 ],
    "children" : [ ]
  }, {
    "dbId" : 10356154,
    "stId" : "R-BTA-354176",
    "displayName" : "Talin:RIAM complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83460 ],
    "parents" : [ 10357430, 10357436, 10357425, 10356158, 10356176 ],
    "children" : [ 10356152, 10356141 ]
  }, {
    "dbId" : 10337721,
    "stId" : "R-BTA-74680",
    "displayName" : "SHC1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 83514 ],
    "identifier" : "Q0IIE2",
    "standardIdentifier" : "uniprot:Q0IIE2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SHC1" ],
    "parents" : [ 10364390 ],
    "children" : [ ]
  }, {
    "dbId" : 10357434,
    "stId" : "R-BTA-377612",
    "displayName" : "Integrin alphaIIb beta3:Inactive (p-Y530)-SRC [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10357436 ],
    "children" : [ 10347482, 10341517 ]
  }, {
    "dbId" : 10356152,
    "stId" : "R-BTA-350713",
    "displayName" : "TLN1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 83459 ],
    "identifier" : "A0A3Q1MLQ7",
    "standardIdentifier" : "uniprot:A0A3Q1MLQ7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TLN1" ],
    "parents" : [ 10356154 ],
    "children" : [ ]
  }, {
    "dbId" : 10357430,
    "stId" : "R-BTA-377619",
    "displayName" : "Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83470 ],
    "parents" : [ ],
    "children" : [ 10356154, 10356156, 377604, 10356174 ]
  }, {
    "dbId" : 10355511,
    "stId" : "R-BTA-3008666",
    "displayName" : "RAPGEF4 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BPX7",
    "standardIdentifier" : "uniprot:E1BPX7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RAPGEF4" ],
    "parents" : [ 10361208 ],
    "children" : [ ]
  }, {
    "dbId" : 10356148,
    "stId" : "R-BTA-377614",
    "displayName" : "Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10356158 ],
    "children" : [ 10356146, 10341517 ]
  }, {
    "dbId" : 10351927,
    "stId" : "R-BTA-201621",
    "displayName" : "PTK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 83480 ],
    "identifier" : "A0A3Q1MAA1",
    "standardIdentifier" : "uniprot:A0A3Q1MAA1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10356160 ],
    "children" : [ ]
  }, {
    "dbId" : 10356277,
    "stId" : "R-BTA-372646",
    "displayName" : "p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83503 ],
    "parents" : [ 10356284 ],
    "children" : [ 10356275, 10356187 ]
  }, {
    "dbId" : 10356146,
    "stId" : "R-BTA-1810408",
    "displayName" : "phospho-MyrG-p-Y419-SRC [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BIM8",
    "standardIdentifier" : "uniprot:E1BIM8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SRC" ],
    "parents" : [ 10356148 ],
    "children" : [ ]
  }, {
    "dbId" : 29356,
    "stId" : "R-ALL-29356",
    "displayName" : "H2O [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 83475 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10356275,
    "stId" : "R-BTA-372645",
    "displayName" : "phospho-BCAR1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1MQ07",
    "standardIdentifier" : "uniprot:A0A3Q1MQ07",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "BCAR1" ],
    "parents" : [ 10356277 ],
    "children" : [ ]
  }, {
    "dbId" : 10356272,
    "stId" : "R-BTA-372688",
    "displayName" : "BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83499 ],
    "parents" : [ ],
    "children" : [ 10356187, 10356270 ]
  }, {
    "dbId" : 10357425,
    "stId" : "R-BTA-377620",
    "displayName" : "Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83477 ],
    "parents" : [ ],
    "children" : [ 10356154, 10356156, 10357423, 377604 ]
  }, {
    "dbId" : 10356270,
    "stId" : "R-BTA-201625",
    "displayName" : "BCAR1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 83498 ],
    "identifier" : "A0A3Q1MQ07",
    "standardIdentifier" : "uniprot:A0A3Q1MQ07",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "BCAR1" ],
    "parents" : [ 10356272 ],
    "children" : [ ]
  }, {
    "dbId" : 10357423,
    "stId" : "R-BTA-1215929",
    "displayName" : "Integrin alphaIIb beta3:SRC [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10357425 ],
    "children" : [ 10347488, 10341517 ]
  }, {
    "dbId" : 10356141,
    "stId" : "R-BTA-354110",
    "displayName" : "Rap1-GTP:PIP2:RIAM [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83457 ],
    "parents" : [ 10356154 ],
    "children" : [ 10356135, 10356139, 179856 ]
  }, {
    "dbId" : 10356139,
    "stId" : "R-BTA-354081",
    "displayName" : "APBB1IP [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 83456 ],
    "identifier" : "Q3MHM0",
    "standardIdentifier" : "uniprot:Q3MHM0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "APBB1IP" ],
    "parents" : [ 10356141 ],
    "children" : [ ]
  }, {
    "dbId" : 10356135,
    "stId" : "R-BTA-354126",
    "displayName" : "RAP1:GTP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83452 ],
    "parents" : [ 10356141 ],
    "children" : [ 29438, 10356133 ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 83488, 83524, 83528, 83501, 83484 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10348836,
    "stId" : "R-BTA-191648",
    "displayName" : "SRC-2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 83530 ],
    "identifier" : "E1BIM8",
    "standardIdentifier" : "uniprot:E1BIM8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SRC" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 83490, 83526, 83529, 83486, 83502 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10356133,
    "stId" : "R-BTA-377600",
    "displayName" : "RAP1 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "parents" : [ 10356208, 10356135 ],
    "children" : [ 10356131, 10356127 ]
  }, {
    "dbId" : 29372,
    "stId" : "R-ALL-29372",
    "displayName" : "Pi [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 83476 ],
    "identifier" : "43474",
    "standardIdentifier" : "chebi:43474",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10356131,
    "stId" : "R-BTA-377590",
    "displayName" : "RAP1B [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P61223",
    "standardIdentifier" : "uniprot:P61223",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10356133 ],
    "children" : [ ]
  }, {
    "dbId" : 10341664,
    "stId" : "R-BTA-58268",
    "displayName" : "SYK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 83521 ],
    "identifier" : "A0A3Q1MHG9",
    "standardIdentifier" : "uniprot:A0A3Q1MHG9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SYK" ],
    "parents" : [ 10363868 ],
    "children" : [ ]
  }, {
    "dbId" : 10363868,
    "stId" : "R-BTA-429424",
    "displayName" : "Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83522 ],
    "parents" : [ ],
    "children" : [ 10341664, 10356158 ]
  }, {
    "dbId" : 10356189,
    "stId" : "R-BTA-354113",
    "displayName" : "GRB2 bound to pPTK2 in Focal adhesion [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83493 ],
    "parents" : [ 10356204 ],
    "children" : [ 10337681, 10356187 ]
  }, {
    "dbId" : 10345561,
    "stId" : "R-BTA-2980677",
    "displayName" : "CRK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 83505 ],
    "identifier" : "E1BQ32",
    "standardIdentifier" : "uniprot:E1BQ32",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CRK" ],
    "parents" : [ 10356284 ],
    "children" : [ ]
  }, {
    "dbId" : 10356187,
    "stId" : "R-BTA-354080",
    "displayName" : "Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83489 ],
    "parents" : [ 10356189, 10356277, 10356272 ],
    "children" : [ 10356185, 10356158 ]
  }, {
    "dbId" : 10347482,
    "stId" : "R-BTA-377598",
    "displayName" : "phospho-MyrG,p-Y530-SRC [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BIM8",
    "standardIdentifier" : "uniprot:E1BIM8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SRC" ],
    "parents" : [ 10357434, 10356172 ],
    "children" : [ ]
  }, {
    "dbId" : 10356185,
    "stId" : "R-BTA-354128",
    "displayName" : "phospho-p-6Y-PTK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1MAA1",
    "standardIdentifier" : "uniprot:A0A3Q1MAA1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10356187 ],
    "children" : [ ]
  }, {
    "dbId" : 114632,
    "stId" : "R-ALL-114632",
    "displayName" : "Mg2+ [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "18420",
    "standardIdentifier" : "chebi:18420",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 377604 ],
    "children" : [ ]
  }, {
    "dbId" : 10340055,
    "stId" : "R-BTA-61459",
    "displayName" : "PDPK1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 83512 ],
    "identifier" : "F1MQJ7",
    "standardIdentifier" : "uniprot:F1MQJ7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10365013,
    "stId" : "R-BTA-443900",
    "displayName" : "Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83517 ],
    "parents" : [ ],
    "children" : [ 10356176, 10337728 ]
  }, {
    "dbId" : 10356176,
    "stId" : "R-BTA-354130",
    "displayName" : "Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83463 ],
    "parents" : [ 10364390, 10365013, 10356200 ],
    "children" : [ 10356154, 10356174 ]
  }, {
    "dbId" : 10356174,
    "stId" : "R-BTA-377608",
    "displayName" : "Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83462, 83469 ],
    "parents" : [ 10357430, 10356176 ],
    "children" : [ 10356172, 10341517 ]
  }, {
    "dbId" : 10356172,
    "stId" : "R-BTA-377606",
    "displayName" : "p-Y530-SRC:CSK [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10356174 ],
    "children" : [ 10347482, 10352491 ]
  }, {
    "dbId" : 114519,
    "stId" : "R-ALL-114519",
    "displayName" : "DAG [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "17815",
    "standardIdentifier" : "chebi:17815",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10356220 ],
    "children" : [ ]
  }, {
    "dbId" : 10356167,
    "stId" : "R-BTA-354135",
    "displayName" : "Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83485 ],
    "parents" : [ ],
    "children" : [ 10356165, 10356158 ]
  }, {
    "dbId" : 10356165,
    "stId" : "R-BTA-354068",
    "displayName" : "phospho-p-Y397-PTK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1MAA1",
    "standardIdentifier" : "uniprot:A0A3Q1MAA1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10356167 ],
    "children" : [ ]
  }, {
    "dbId" : 10337728,
    "stId" : "R-BTA-74684",
    "displayName" : "phospho-SHC1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 83519 ],
    "identifier" : "Q0IIE2",
    "standardIdentifier" : "uniprot:Q0IIE2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SHC1" ],
    "parents" : [ 10365013 ],
    "children" : [ ]
  }, {
    "dbId" : 10356160,
    "stId" : "R-BTA-354103",
    "displayName" : "Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83482 ],
    "parents" : [ ],
    "children" : [ 10351927, 10356158 ]
  }, {
    "dbId" : 10356220,
    "stId" : "R-BTA-392841",
    "displayName" : "CalDAG-GEFs:DAG:Ca2+ [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83453 ],
    "parents" : [ ],
    "children" : [ 114519, 10356218, 74016 ]
  }, {
    "dbId" : 10356218,
    "stId" : "R-BTA-392488",
    "displayName" : "CalDAG-GEFs [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "parents" : [ 10356220 ],
    "children" : [ 10356212, 10356216 ]
  }, {
    "dbId" : 10356216,
    "stId" : "R-BTA-870270",
    "displayName" : "RASGRP1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BG59",
    "standardIdentifier" : "uniprot:E1BG59",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RASGRP1" ],
    "parents" : [ 10356218 ],
    "children" : [ ]
  }, {
    "dbId" : 10361208,
    "stId" : "R-BTA-392485",
    "displayName" : "Rap1 cAMP-GEFs [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 83508 ],
    "parents" : [ ],
    "children" : [ 10355511, 10355517 ]
  }, {
    "dbId" : 10356212,
    "stId" : "R-BTA-3008671",
    "displayName" : "RASGRP2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A6N9I4",
    "standardIdentifier" : "uniprot:A6N9I4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10356218 ],
    "children" : [ ]
  }, {
    "dbId" : 29420,
    "stId" : "R-ALL-29420",
    "displayName" : "GDP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 83451 ],
    "identifier" : "58189",
    "standardIdentifier" : "chebi:58189",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10356208 ],
    "children" : [ ]
  }, {
    "dbId" : 10356208,
    "stId" : "R-BTA-354074",
    "displayName" : "RAP1:GDP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83449 ],
    "parents" : [ ],
    "children" : [ 29420, 10356133 ]
  }, {
    "dbId" : 10341615,
    "stId" : "R-BTA-67271",
    "displayName" : "VWF [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1LLU1",
    "standardIdentifier" : "uniprot:A0A3Q1LLU1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "VWF" ],
    "parents" : [ 10356156 ],
    "children" : [ ]
  }, {
    "dbId" : 10356204,
    "stId" : "R-BTA-354168",
    "displayName" : "GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83496 ],
    "parents" : [ ],
    "children" : [ 10337685, 10356189 ]
  }, {
    "dbId" : 10364397,
    "stId" : "R-BTA-432105",
    "displayName" : "Integrin alpha IIb p(T779)-beta 3 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83511 ],
    "parents" : [ ],
    "children" : [ 10341511, 10364395 ]
  }, {
    "dbId" : 10364395,
    "stId" : "R-BTA-432107",
    "displayName" : "phospho-ITGB3 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MTN1",
    "standardIdentifier" : "uniprot:F1MTN1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ITGB3" ],
    "parents" : [ 10364397 ],
    "children" : [ ]
  }, {
    "dbId" : 10352491,
    "stId" : "R-BTA-203776",
    "displayName" : "CSK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 83473 ],
    "identifier" : "Q0VBZ0",
    "standardIdentifier" : "uniprot:Q0VBZ0",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10356172 ],
    "children" : [ ]
  }, {
    "dbId" : 10356200,
    "stId" : "R-BTA-354137",
    "displayName" : "Focal complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83467 ],
    "parents" : [ ],
    "children" : [ 10356176, 10356156, 377604 ]
  }, {
    "dbId" : 266099,
    "stId" : "R-ALL-266099",
    "displayName" : "Mn2+ [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "29035",
    "standardIdentifier" : "chebi:29035",
    "chebiIdentifier" : "chebi:29035",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 377604 ],
    "children" : [ ]
  }, {
    "dbId" : 10364390,
    "stId" : "R-BTA-432098",
    "displayName" : "Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83515 ],
    "parents" : [ ],
    "children" : [ 10356176, 10337721 ]
  }, {
    "dbId" : 10347488,
    "stId" : "R-BTA-8876922",
    "displayName" : "MyrG-SRC [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BIM8",
    "standardIdentifier" : "uniprot:E1BIM8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SRC" ],
    "parents" : [ 10357423 ],
    "children" : [ ]
  }, {
    "dbId" : 10363875,
    "stId" : "R-BTA-429434",
    "displayName" : "Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 83525 ],
    "parents" : [ ],
    "children" : [ 10363873, 10356158 ]
  }, {
    "dbId" : 29438,
    "stId" : "R-ALL-29438",
    "displayName" : "GTP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 83450 ],
    "identifier" : "37565",
    "standardIdentifier" : "chebi:37565",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10356135 ],
    "children" : [ ]
  }, {
    "dbId" : 10363873,
    "stId" : "R-BTA-429432",
    "displayName" : "phospho-SYK [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1MHG9",
    "standardIdentifier" : "uniprot:A0A3Q1MHG9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SYK" ],
    "parents" : [ 10363875 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10363870,
    "stId" : "R-BTA-429415",
    "displayName" : "SYK binds to integrin alphaIIb beta3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10357428 ],
    "following" : [ 10363878 ],
    "inputs" : [ 10341664, 10356158 ],
    "outputs" : [ 10363868 ],
    "efs" : [ ],
    "diagramIds" : [ 83520 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10356286,
    "stId" : "R-BTA-372697",
    "displayName" : "Crk binding to p130cas",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10356282 ],
    "inputs" : [ 10356277, 10345561 ],
    "outputs" : [ 10356284 ],
    "efs" : [ ],
    "diagramIds" : [ 83504 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10356223,
    "stId" : "R-BTA-354173",
    "displayName" : "Activation of Rap1 by cytosolic GEFs",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10356143 ],
    "inputs" : [ 29438, 10356208 ],
    "outputs" : [ 29420, 10356135 ],
    "catalysts" : [ 10356220 ],
    "efs" : [ ],
    "diagramIds" : [ 83448 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10356191,
    "stId" : "R-BTA-354087",
    "displayName" : "Recruitment of GRB2 to p-PTK2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10356198 ],
    "following" : [ 10356206 ],
    "inputs" : [ 10337681, 10356187 ],
    "outputs" : [ 10356189 ],
    "efs" : [ ],
    "diagramIds" : [ 83491 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10356282,
    "stId" : "R-BTA-372693",
    "displayName" : "Phosphorylation of BCAR1 by SRC-PTK2 complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10356288 ],
    "following" : [ 10356286 ],
    "inputs" : [ 10356272, 113592 ],
    "outputs" : [ 10356277, 29370 ],
    "catalysts" : [ 10356272 ],
    "efs" : [ ],
    "diagramIds" : [ 83500 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10357432,
    "stId" : "R-BTA-377641",
    "displayName" : "Clustering of Integrin alphaIIb beta3 complexes",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10356202 ],
    "following" : [ 10357443 ],
    "inputs" : [ 10356200, 10356174 ],
    "outputs" : [ 10357430 ],
    "efs" : [ ],
    "diagramIds" : [ 83468 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10365017,
    "stId" : "R-BTA-443910",
    "displayName" : "SHC1 dissociates from integrin alphaIIb beta3",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10365015 ],
    "inputs" : [ 10365013 ],
    "outputs" : [ 10356176, 10337728 ],
    "efs" : [ ],
    "diagramIds" : [ 83518 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10365015,
    "stId" : "R-BTA-443905",
    "displayName" : "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10364392 ],
    "following" : [ 10365017 ],
    "inputs" : [ 10364390 ],
    "outputs" : [ 10365013 ],
    "efs" : [ ],
    "diagramIds" : [ 83516 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10357428,
    "stId" : "R-BTA-377640",
    "displayName" : "Autophosphorylation of SRC",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10357441 ],
    "following" : [ 10363870, 10356162 ],
    "inputs" : [ 10357425, 113592 ],
    "outputs" : [ 29370, 10356158 ],
    "catalysts" : [ 10348836 ],
    "efs" : [ ],
    "diagramIds" : [ 83527 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10356178,
    "stId" : "R-BTA-354077",
    "displayName" : "Integrin alphaIIb beta3 activation",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10356193 ],
    "following" : [ 10364392, 10356202 ],
    "inputs" : [ 10356154, 10356174 ],
    "outputs" : [ 10356176 ],
    "efs" : [ ],
    "diagramIds" : [ 83461 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10364400,
    "stId" : "R-BTA-432110",
    "displayName" : "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10364392 ],
    "inputs" : [ 10341517 ],
    "outputs" : [ 10364397 ],
    "catalysts" : [ 10340055 ],
    "efs" : [ ],
    "diagramIds" : [ 83509 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10356206,
    "stId" : "R-BTA-354165",
    "displayName" : "Interaction of SOS with GRB2 bound to FADK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10356191 ],
    "inputs" : [ 10337685, 10356189 ],
    "outputs" : [ 10356204 ],
    "efs" : [ ],
    "diagramIds" : [ 83494 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10356143,
    "stId" : "R-BTA-354060",
    "displayName" : "Translocation of RIAM to plasma membrane",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10370696, 10356223 ],
    "following" : [ 10356193 ],
    "inputs" : [ 10356135, 10356139, 179856 ],
    "outputs" : [ 10356141 ],
    "efs" : [ ],
    "diagramIds" : [ 83454 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10356202,
    "stId" : "R-BTA-354149",
    "displayName" : "Interaction of integrin alphaIIb beta3 with Fibrinogen",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10356178 ],
    "following" : [ 10357432 ],
    "inputs" : [ 10356176, 10356156, 377604 ],
    "outputs" : [ 10356200 ],
    "efs" : [ ],
    "diagramIds" : [ 83464 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10356170,
    "stId" : "R-BTA-354073",
    "displayName" : "Autophosphorylation of PTK2 at Y397",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10356162 ],
    "following" : [ 10356198 ],
    "inputs" : [ 10356160, 113592 ],
    "outputs" : [ 29370, 10356167 ],
    "catalysts" : [ 10356160 ],
    "efs" : [ ],
    "diagramIds" : [ 83483 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10370696,
    "stId" : "R-BTA-939265",
    "displayName" : "Activation of Rap1 by membrane-associated GEFs",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10356143 ],
    "inputs" : [ 29438, 10356208 ],
    "outputs" : [ 29420, 10356135 ],
    "catalysts" : [ 10361208 ],
    "efs" : [ ],
    "diagramIds" : [ 83507 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10364392,
    "stId" : "R-BTA-432096",
    "displayName" : "Activated integrin alphaIIb beta3 binds SHC1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10364400, 10356178 ],
    "following" : [ 10365015 ],
    "inputs" : [ 10356176, 10337721 ],
    "outputs" : [ 10364390 ],
    "efs" : [ ],
    "diagramIds" : [ 83513 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10356198,
    "stId" : "R-BTA-354124",
    "displayName" : "Phosphorylation of pPTK2 by SRC",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10356170 ],
    "following" : [ 10356191, 10356288 ],
    "inputs" : [ 113592, 10356167 ],
    "outputs" : [ 29370, 10356187 ],
    "catalysts" : [ 10356167 ],
    "efs" : [ ],
    "diagramIds" : [ 83487 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10363878,
    "stId" : "R-BTA-429441",
    "displayName" : "SYK activation by SRC",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10363870 ],
    "inputs" : [ 113592, 10363868 ],
    "outputs" : [ 10363875, 29370 ],
    "catalysts" : [ 10363868 ],
    "efs" : [ ],
    "diagramIds" : [ 83523 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10356162,
    "stId" : "R-BTA-354066",
    "displayName" : "Translocation of PTK2 to Focal complexes",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10357428 ],
    "following" : [ 10356170 ],
    "inputs" : [ 10351927, 10356158 ],
    "outputs" : [ 10356160 ],
    "efs" : [ ],
    "diagramIds" : [ 83479 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10357443,
    "stId" : "R-BTA-377644",
    "displayName" : "Release of CSK from SRC",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10357432 ],
    "following" : [ 10357441 ],
    "inputs" : [ 10357430 ],
    "outputs" : [ 10352491, 10357436 ],
    "efs" : [ ],
    "diagramIds" : [ 83471 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10356288,
    "stId" : "R-BTA-372705",
    "displayName" : "Recruitment of BCAR1 to PTK2 complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10356198 ],
    "following" : [ 10356282 ],
    "inputs" : [ 10356187, 10356270 ],
    "outputs" : [ 10356272 ],
    "efs" : [ ],
    "diagramIds" : [ 83497 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10356193,
    "stId" : "R-BTA-354097",
    "displayName" : "Activation of Talin",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10356143 ],
    "following" : [ 10356178 ],
    "inputs" : [ 10356152, 10356141 ],
    "outputs" : [ 10356154 ],
    "efs" : [ ],
    "diagramIds" : [ 83458 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10357441,
    "stId" : "R-BTA-377643",
    "displayName" : "Dephosphorylation of inactive SRC by PTPB1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10357443 ],
    "following" : [ 10357428 ],
    "inputs" : [ 29356, 10357436 ],
    "outputs" : [ 10357425, 29372 ],
    "catalysts" : [ 10357438 ],
    "efs" : [ ],
    "diagramIds" : [ 83474 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10444310,
    "stId" : "R-BTA-372708",
    "displayName" : "p130Cas linkage to MAPK signaling for integrins",
    "events" : [ 10356286, 10356282, 10356288 ]
  }, {
    "dbId" : 10444302,
    "stId" : "R-BTA-354194",
    "displayName" : "GRB2:SOS provides linkage to MAPK signaling for Integrins ",
    "events" : [ 10356206, 10356191 ]
  } ]
}