{
  "dbId" : 10445298,
  "stId" : "R-BTA-3215018",
  "speciesName" : "Bos taurus",
  "nodes" : [ {
    "dbId" : 10391006,
    "stId" : "R-BTA-912481",
    "displayName" : "UBE2I [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 47574 ],
    "identifier" : "A6H744",
    "standardIdentifier" : "uniprot:A6H744",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBE2I" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113541,
    "stId" : "R-ALL-113541",
    "displayName" : "PPi [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 47572 ],
    "identifier" : "33019",
    "standardIdentifier" : "chebi:33019",
    "chebiIdentifier" : "chebi:33019",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10390936,
    "stId" : "R-BTA-2984281",
    "displayName" : "SUMO2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 47563 ],
    "identifier" : "P61955",
    "standardIdentifier" : "uniprot:P61955",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SUMO2" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10391000,
    "stId" : "R-BTA-2984269",
    "displayName" : "SUMO3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 47566 ],
    "identifier" : "Q17QV3",
    "standardIdentifier" : "uniprot:Q17QV3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SUMO3" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10390934,
    "stId" : "R-BTA-2990837",
    "displayName" : "SUMO2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 47562 ],
    "identifier" : "P61955",
    "standardIdentifier" : "uniprot:P61955",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SUMO2" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10390998,
    "stId" : "R-BTA-2990830",
    "displayName" : "SUMO3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 47565 ],
    "identifier" : "Q17QV3",
    "standardIdentifier" : "uniprot:Q17QV3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SUMO3" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10390927,
    "stId" : "R-BTA-2990834",
    "displayName" : "SENP1,2,5 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 47560 ],
    "parents" : [ ],
    "children" : [ 10390917, 10390921, 10390925 ]
  }, {
    "dbId" : 10390925,
    "stId" : "R-BTA-2984297",
    "displayName" : "SENP5 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MBS6",
    "standardIdentifier" : "uniprot:F1MBS6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SENP5" ],
    "parents" : [ 10390927 ],
    "children" : [ ]
  }, {
    "dbId" : 10390921,
    "stId" : "R-BTA-2984298",
    "displayName" : "SENP2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BAI5",
    "standardIdentifier" : "uniprot:E1BAI5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SENP2" ],
    "parents" : [ 10390927 ],
    "children" : [ ]
  }, {
    "dbId" : 10390917,
    "stId" : "R-BTA-2984299",
    "displayName" : "SENP1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MG84",
    "standardIdentifier" : "uniprot:F1MG84",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SENP1" ],
    "parents" : [ 10390927 ],
    "children" : [ ]
  }, {
    "dbId" : 164121,
    "stId" : "R-ALL-164121",
    "displayName" : "AMP [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 47571 ],
    "identifier" : "456215",
    "standardIdentifier" : "chebi:456215",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10390913,
    "stId" : "R-BTA-2990831-3",
    "displayName" : "Homologues of SUMO1(2-101) [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 47558 ],
    "parents" : [ ],
    "children" : [ 10390909, 10390911 ]
  }, {
    "dbId" : 10390911,
    "stId" : "R-BTA-2990831-2",
    "displayName" : "SUMO1(2-101) [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1M4Y4",
    "standardIdentifier" : "uniprot:A0A3Q1M4Y4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10390913 ],
    "children" : [ ]
  }, {
    "dbId" : 10390909,
    "stId" : "R-BTA-2990831",
    "displayName" : "SUMO1(2-101) [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1M137",
    "standardIdentifier" : "uniprot:A0A3Q1M137",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10390913 ],
    "children" : [ ]
  }, {
    "dbId" : 10390904,
    "stId" : "R-BTA-2993793",
    "displayName" : "SUMO1:UBA2:SAE1 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 47570 ],
    "parents" : [ ],
    "children" : [ 10390883, 10390902 ]
  }, {
    "dbId" : 10368824,
    "stId" : "R-BTA-877304-3",
    "displayName" : "Homologues of SUMO1 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 47559 ],
    "parents" : [ ],
    "children" : [ 10368818, 10368822 ]
  }, {
    "dbId" : 10390902,
    "stId" : "R-BTA-2993786",
    "displayName" : "SUMO1:UBA2 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10390904 ],
    "children" : [ 10390900, 10390892 ]
  }, {
    "dbId" : 10368822,
    "stId" : "R-BTA-877304-2",
    "displayName" : "SUMO1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1M4Y4",
    "standardIdentifier" : "uniprot:A0A3Q1M4Y4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10368824 ],
    "children" : [ ]
  }, {
    "dbId" : 10390900,
    "stId" : "R-BTA-3730616-3",
    "displayName" : "Homologues of UBA2-G97-SUMO1 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "parents" : [ 10390902 ],
    "children" : [ 10390898, 10390895 ]
  }, {
    "dbId" : 10390898,
    "stId" : "R-BTA-3730616-2",
    "displayName" : "UBA2-G97-SUMO1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1M4Y4",
    "standardIdentifier" : "uniprot:A0A3Q1M4Y4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10390900 ],
    "children" : [ ]
  }, {
    "dbId" : 10368818,
    "stId" : "R-BTA-877304",
    "displayName" : "SUMO1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1M137",
    "standardIdentifier" : "uniprot:A0A3Q1M137",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10368824 ],
    "children" : [ ]
  }, {
    "dbId" : 10391024,
    "stId" : "R-BTA-8932136",
    "displayName" : "RWDD2B [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 47576 ],
    "identifier" : "F1N2B3",
    "standardIdentifier" : "uniprot:F1N2B3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RWDD2B" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29358,
    "stId" : "R-ALL-29358",
    "displayName" : "ATP [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 47568 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10390895,
    "stId" : "R-BTA-3730616",
    "displayName" : "UBA2-G97-SUMO1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1M137",
    "standardIdentifier" : "uniprot:A0A3Q1M137",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10390900 ],
    "children" : [ ]
  }, {
    "dbId" : 10390892,
    "stId" : "R-BTA-3730628",
    "displayName" : "SUMO1-C173-UBA2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A4FV12",
    "standardIdentifier" : "uniprot:A4FV12",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10390902 ],
    "children" : [ ]
  }, {
    "dbId" : 10391019,
    "stId" : "R-BTA-2993783",
    "displayName" : "SUMO1:C93-UBE2I [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 47575 ],
    "parents" : [ ],
    "children" : [ 10391017, 10391009 ]
  }, {
    "dbId" : 10390889,
    "stId" : "R-BTA-2990843",
    "displayName" : "UBA2:SAE1 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 47569 ],
    "parents" : [ ],
    "children" : [ 10390883, 10390887 ]
  }, {
    "dbId" : 10391017,
    "stId" : "R-BTA-3730622-3",
    "displayName" : "Homologues of UBE2I-G97-SUMO1 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "parents" : [ 10391019 ],
    "children" : [ 10391012, 10391015 ]
  }, {
    "dbId" : 10390887,
    "stId" : "R-BTA-947696",
    "displayName" : "UBA2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A4FV12",
    "standardIdentifier" : "uniprot:A4FV12",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10390889 ],
    "children" : [ ]
  }, {
    "dbId" : 10391015,
    "stId" : "R-BTA-3730622-2",
    "displayName" : "UBE2I-G97-SUMO1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1M4Y4",
    "standardIdentifier" : "uniprot:A0A3Q1M4Y4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10391017 ],
    "children" : [ ]
  }, {
    "dbId" : 10391012,
    "stId" : "R-BTA-3730622",
    "displayName" : "UBE2I-G97-SUMO1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1M137",
    "standardIdentifier" : "uniprot:A0A3Q1M137",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10391017 ],
    "children" : [ ]
  }, {
    "dbId" : 10390883,
    "stId" : "R-BTA-947697",
    "displayName" : "SAE1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A2VE14",
    "standardIdentifier" : "uniprot:A2VE14",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SAE1" ],
    "parents" : [ 10390904, 10390889 ],
    "children" : [ ]
  }, {
    "dbId" : 10391009,
    "stId" : "R-BTA-3730617",
    "displayName" : "UBE2I [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A6H744",
    "standardIdentifier" : "uniprot:A6H744",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBE2I" ],
    "parents" : [ 10391019 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10390938,
    "stId" : "R-BTA-2990842",
    "displayName" : "SENP1,2,5 proteolytically process SUMO2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10390934 ],
    "outputs" : [ 10390936 ],
    "catalysts" : [ 10390927 ],
    "efs" : [ ],
    "diagramIds" : [ 47561 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10391002,
    "stId" : "R-BTA-2993763",
    "displayName" : "SENP1,2,5 proteolytically process SUMO3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10390998 ],
    "outputs" : [ 10391000 ],
    "catalysts" : [ 10390927 ],
    "efs" : [ ],
    "diagramIds" : [ 47564 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10390907,
    "stId" : "R-BTA-2990833",
    "displayName" : "Conjugation of SUMO1 to UBA2:SAE1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10390930 ],
    "following" : [ 10391026 ],
    "inputs" : [ 29358, 10390889, 10368824 ],
    "outputs" : [ 164121, 10390904, 113541 ],
    "catalysts" : [ 10390889 ],
    "efs" : [ ],
    "diagramIds" : [ 47567 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10391026,
    "stId" : "R-BTA-2993780",
    "displayName" : "Transfer of SUMO1 from E1 to UBE2I (UBC9)",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10390907 ],
    "inputs" : [ 10391006, 10390904 ],
    "outputs" : [ 10391019, 10390889 ],
    "catalysts" : [ 10390889 ],
    "efs" : [ ],
    "activators" : [ 10391024 ],
    "diagramIds" : [ 47573 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10390930,
    "stId" : "R-BTA-2990840",
    "displayName" : "SENP1,2,5 proteolytically process SUMO1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10390907 ],
    "inputs" : [ 10390913 ],
    "outputs" : [ 10368824 ],
    "catalysts" : [ 10390927 ],
    "efs" : [ ],
    "diagramIds" : [ 47557 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10445306,
    "stId" : "R-BTA-3065678",
    "displayName" : "SUMO is transferred from E1 to E2 (UBE2I, UBC9)",
    "events" : [ 10391026 ]
  }, {
    "dbId" : 10445296,
    "stId" : "R-BTA-3065676",
    "displayName" : "SUMO is conjugated to E1 (UBA2:SAE1)",
    "events" : [ 10390907 ]
  }, {
    "dbId" : 10445302,
    "stId" : "R-BTA-3065679",
    "displayName" : "SUMO is proteolytically processed",
    "events" : [ 10390938, 10391002, 10390930 ]
  } ]
}