{
  "dbId" : 10445260,
  "stableId" : "R-BTA-2408522",
  "displayName" : "Selenoamino acid metabolism",
  "nodes" : [ {
    "id" : 103133,
    "reactomeId" : 5357707,
    "displayName" : "SeMet",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 610,
      "y" : 196
    },
    "minX" : 440,
    "maxX" : 637,
    "minY" : 180,
    "maxY" : 244,
    "prop" : {
      "x" : 585,
      "y" : 181,
      "width" : 51,
      "height" : 30
    },
    "textPosition" : {
      "x" : 587,
      "y" : 185
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 631,
          "y" : 186
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 631,
          "y" : 186
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103132,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 582,
          "y" : 203
        },
        "to" : {
          "x" : 440,
          "y" : 244
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 103135,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 443,
      "y" : 185
    },
    "minX" : 422,
    "maxX" : 466,
    "minY" : 169,
    "maxY" : 244,
    "prop" : {
      "x" : 422,
      "y" : 170,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 426,
      "y" : 174
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 460,
          "y" : 175
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 460,
          "y" : 175
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103132,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 442,
          "y" : 203
        },
        "to" : {
          "x" : 440,
          "y" : 244
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 103134,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 339,
      "y" : 207
    },
    "minX" : 319,
    "maxX" : 440,
    "minY" : 191,
    "maxY" : 244,
    "prop" : {
      "x" : 319,
      "y" : 192,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 323,
      "y" : 196
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 354,
          "y" : 197
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 354,
          "y" : 197
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103132,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 362,
          "y" : 214
        },
        "to" : {
          "x" : 440,
          "y" : 244
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 103137,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 527,
      "y" : 482
    },
    "minX" : 443,
    "maxX" : 544,
    "minY" : 402,
    "maxY" : 497,
    "prop" : {
      "x" : 512,
      "y" : 467,
      "width" : 31,
      "height" : 30
    },
    "textPosition" : {
      "x" : 518,
      "y" : 471
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 538,
          "y" : 472
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 538,
          "y" : 472
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103132,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 509,
          "y" : 467
        },
        "to" : {
          "x" : 443,
          "y" : 402
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 501,
          "y" : 465
        },
        "b" : {
          "x" : 509,
          "y" : 467
        },
        "c" : {
          "x" : 507,
          "y" : 459
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 507,
          "y" : 459
        }
      }
    } ]
  }, {
    "id" : 103136,
    "reactomeId" : 5357652,
    "displayName" : "AdoSeMet",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 341,
      "y" : 458
    },
    "minX" : 304,
    "maxX" : 443,
    "minY" : 402,
    "maxY" : 473,
    "prop" : {
      "x" : 304,
      "y" : 443,
      "width" : 74,
      "height" : 30
    },
    "textPosition" : {
      "x" : 305,
      "y" : 447
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 373,
          "y" : 448
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 373,
          "y" : 448
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103132,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 368,
          "y" : 440
        },
        "to" : {
          "x" : 443,
          "y" : 402
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 372,
          "y" : 433
        },
        "b" : {
          "x" : 368,
          "y" : 440
        },
        "c" : {
          "x" : 376,
          "y" : 440
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 376,
          "y" : 440
        }
      }
    } ]
  }, {
    "id" : 103139,
    "reactomeId" : 10346656,
    "displayName" : "MAT1A multimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 525,
      "y" : 307
    },
    "minX" : 449,
    "maxX" : 566,
    "minY" : 289,
    "maxY" : 325,
    "prop" : {
      "x" : 485,
      "y" : 289,
      "width" : 81,
      "height" : 36
    },
    "textPosition" : {
      "x" : 491,
      "y" : 289
    },
    "connectors" : [ {
      "edgeId" : 103132,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 479,
          "y" : 307
        },
        "to" : {
          "x" : 457,
          "y" : 308
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 453,
          "y" : 308
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 453,
          "y" : 308
        }
      }
    } ]
  }, {
    "id" : 103138,
    "reactomeId" : 111294,
    "displayName" : "PPi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 463,
      "y" : 495
    },
    "minX" : 443,
    "maxX" : 481,
    "minY" : 402,
    "maxY" : 510,
    "prop" : {
      "x" : 446,
      "y" : 480,
      "width" : 34,
      "height" : 30
    },
    "textPosition" : {
      "x" : 449,
      "y" : 484
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 475,
          "y" : 485
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 475,
          "y" : 485
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103132,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 459,
          "y" : 477
        },
        "to" : {
          "x" : 443,
          "y" : 402
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 454,
          "y" : 471
        },
        "b" : {
          "x" : 459,
          "y" : 477
        },
        "c" : {
          "x" : 461,
          "y" : 469
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 461,
          "y" : 469
        }
      }
    } ]
  }, {
    "id" : 103141,
    "reactomeId" : 1131953,
    "displayName" : "hydrogen donor",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 641,
      "y" : 739
    },
    "minX" : 587,
    "maxX" : 714,
    "minY" : 722,
    "maxY" : 755,
    "prop" : {
      "x" : 587,
      "y" : 724,
      "width" : 109,
      "height" : 31
    },
    "textPosition" : {
      "x" : 587,
      "y" : 729
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 691,
          "y" : 729
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 691,
          "y" : 729
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103140,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 699,
          "y" : 726
        },
        "to" : {
          "x" : 714,
          "y" : 722
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 103143,
    "reactomeId" : 29432,
    "displayName" : "L-Ala",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 658,
      "y" : 661
    },
    "minX" : 635,
    "maxX" : 723,
    "minY" : 644,
    "maxY" : 676,
    "prop" : {
      "x" : 635,
      "y" : 646,
      "width" : 47,
      "height" : 30
    },
    "textPosition" : {
      "x" : 640,
      "y" : 650
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 677,
          "y" : 651
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 677,
          "y" : 651
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103140,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 685,
          "y" : 654
        },
        "to" : {
          "x" : 723,
          "y" : 644
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 691,
          "y" : 648
        },
        "b" : {
          "x" : 685,
          "y" : 654
        },
        "c" : {
          "x" : 693,
          "y" : 656
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 693,
          "y" : 656
        }
      }
    } ]
  }, {
    "id" : 103142,
    "reactomeId" : 5357697,
    "displayName" : "Sec",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 720,
      "y" : 768
    },
    "minX" : 702,
    "maxX" : 739,
    "minY" : 722,
    "maxY" : 783,
    "prop" : {
      "x" : 702,
      "y" : 753,
      "width" : 36,
      "height" : 30
    },
    "textPosition" : {
      "x" : 704,
      "y" : 757
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 733,
          "y" : 758
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 733,
          "y" : 758
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103140,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 718,
          "y" : 750
        },
        "to" : {
          "x" : 714,
          "y" : 722
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 103145,
    "reactomeId" : 5357660,
    "displayName" : "selanide",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 741,
      "y" : 590
    },
    "minX" : 710,
    "maxX" : 773,
    "minY" : 575,
    "maxY" : 644,
    "prop" : {
      "x" : 710,
      "y" : 576,
      "width" : 62,
      "height" : 28
    },
    "textPosition" : {
      "x" : 710,
      "y" : 579
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 767,
          "y" : 581
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 767,
          "y" : 581
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103140,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 736,
          "y" : 607
        },
        "to" : {
          "x" : 723,
          "y" : 644
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 737,
          "y" : 615
        },
        "b" : {
          "x" : 736,
          "y" : 607
        },
        "c" : {
          "x" : 730,
          "y" : 612
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 730,
          "y" : 612
        }
      }
    } ]
  }, {
    "id" : 103144,
    "reactomeId" : 1130886,
    "displayName" : "hydrogen acceptor",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 579,
      "y" : 628
    },
    "minX" : 517,
    "maxX" : 723,
    "minY" : 612,
    "maxY" : 644,
    "prop" : {
      "x" : 517,
      "y" : 613,
      "width" : 125,
      "height" : 31
    },
    "textPosition" : {
      "x" : 544,
      "y" : 611
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 637,
          "y" : 618
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 637,
          "y" : 618
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103140,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 645,
          "y" : 634
        },
        "to" : {
          "x" : 723,
          "y" : 644
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 652,
          "y" : 631
        },
        "b" : {
          "x" : 645,
          "y" : 634
        },
        "c" : {
          "x" : 651,
          "y" : 639
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 651,
          "y" : 639
        }
      }
    } ]
  }, {
    "id" : 103147,
    "reactomeId" : 10388994,
    "displayName" : "PXLP-K259-SCLY dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 558,
      "y" : 688
    },
    "minX" : 514,
    "maxX" : 705,
    "minY" : 661,
    "maxY" : 710,
    "prop" : {
      "x" : 514,
      "y" : 667,
      "width" : 88,
      "height" : 43
    },
    "textPosition" : {
      "x" : 520,
      "y" : 675
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 602,
          "y" : 667
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 602,
          "y" : 667
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103140,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 605,
          "y" : 686
        },
        "to" : {
          "x" : 697,
          "y" : 683
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 701,
          "y" : 682
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 701,
          "y" : 682
        }
      }
    } ]
  }, {
    "id" : 103146,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 670,
      "y" : 613
    },
    "minX" : 652,
    "maxX" : 723,
    "minY" : 597,
    "maxY" : 644,
    "prop" : {
      "x" : 652,
      "y" : 598,
      "width" : 36,
      "height" : 30
    },
    "textPosition" : {
      "x" : 656,
      "y" : 602
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 683,
          "y" : 603
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 683,
          "y" : 603
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103140,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 691,
          "y" : 623
        },
        "to" : {
          "x" : 723,
          "y" : 644
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 699,
          "y" : 623
        },
        "b" : {
          "x" : 691,
          "y" : 623
        },
        "c" : {
          "x" : 695,
          "y" : 630
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 695,
          "y" : 630
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 103149,
    "reactomeId" : 29364,
    "displayName" : "NADPH",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 889,
      "y" : 236
    },
    "minX" : 860,
    "maxX" : 950,
    "minY" : 220,
    "maxY" : 262,
    "prop" : {
      "x" : 860,
      "y" : 221,
      "width" : 59,
      "height" : 30
    },
    "textPosition" : {
      "x" : 864,
      "y" : 225
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 914,
          "y" : 226
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 914,
          "y" : 226
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103148,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 922,
          "y" : 248
        },
        "to" : {
          "x" : 950,
          "y" : 262
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 103151,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 947,
      "y" : 194
    },
    "minX" : 929,
    "maxX" : 966,
    "minY" : 178,
    "maxY" : 262,
    "prop" : {
      "x" : 929,
      "y" : 179,
      "width" : 36,
      "height" : 30
    },
    "textPosition" : {
      "x" : 933,
      "y" : 183
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 960,
          "y" : 184
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 960,
          "y" : 184
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103148,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 947,
          "y" : 212
        },
        "to" : {
          "x" : 950,
          "y" : 262
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 103150,
    "reactomeId" : 5357663,
    "displayName" : "MeSeOH",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1007,
      "y" : 224
    },
    "minX" : 950,
    "maxX" : 1088,
    "minY" : 200,
    "maxY" : 262,
    "prop" : {
      "x" : 975,
      "y" : 209,
      "width" : 65,
      "height" : 30
    },
    "textPosition" : {
      "x" : 977,
      "y" : 213
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1035,
          "y" : 214
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1035,
          "y" : 214
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103156,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1043,
          "y" : 214
        },
        "to" : {
          "x" : 1088,
          "y" : 200
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1048,
          "y" : 208
        },
        "b" : {
          "x" : 1043,
          "y" : 214
        },
        "c" : {
          "x" : 1051,
          "y" : 216
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1051,
          "y" : 216
        }
      }
    }, {
      "edgeId" : 103148,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 984,
          "y" : 242
        },
        "to" : {
          "x" : 950,
          "y" : 262
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 103153,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 957,
      "y" : 388
    },
    "minX" : 871,
    "maxX" : 980,
    "minY" : 372,
    "maxY" : 403,
    "prop" : {
      "x" : 936,
      "y" : 373,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 940,
      "y" : 377
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 974,
          "y" : 378
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 974,
          "y" : 378
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103148,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 933,
          "y" : 388
        },
        "to" : {
          "x" : 871,
          "y" : 391
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 926,
          "y" : 392
        },
        "b" : {
          "x" : 933,
          "y" : 388
        },
        "c" : {
          "x" : 926,
          "y" : 384
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 926,
          "y" : 384
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 103152,
    "reactomeId" : 5357669,
    "displayName" : "MeSeH",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 728,
      "y" : 420
    },
    "minX" : 700,
    "maxX" : 871,
    "minY" : 391,
    "maxY" : 435,
    "prop" : {
      "x" : 700,
      "y" : 405,
      "width" : 56,
      "height" : 30
    },
    "textPosition" : {
      "x" : 702,
      "y" : 409
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 751,
          "y" : 410
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 751,
          "y" : 410
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103148,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 759,
          "y" : 414
        },
        "to" : {
          "x" : 871,
          "y" : 391
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 765,
          "y" : 409
        },
        "b" : {
          "x" : 759,
          "y" : 414
        },
        "c" : {
          "x" : 767,
          "y" : 417
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 767,
          "y" : 417
        }
      }
    } ]
  }, {
    "id" : 103155,
    "reactomeId" : 10336634,
    "displayName" : "TNXRD1:FAD dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 882,
      "y" : 298
    },
    "minX" : 844,
    "maxX" : 944,
    "minY" : 272,
    "maxY" : 350,
    "prop" : {
      "x" : 844,
      "y" : 278,
      "width" : 76,
      "height" : 40
    },
    "textPosition" : {
      "x" : 846,
      "y" : 283
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 920,
          "y" : 278
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 920,
          "y" : 278
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103148,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 906,
          "y" : 321
        },
        "to" : {
          "x" : 937,
          "y" : 344
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 940,
          "y" : 346
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 940,
          "y" : 346
        }
      }
    } ]
  }, {
    "id" : 103154,
    "reactomeId" : 29366,
    "displayName" : "NADP+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 881,
      "y" : 346
    },
    "minX" : 851,
    "maxX" : 912,
    "minY" : 330,
    "maxY" : 391,
    "prop" : {
      "x" : 851,
      "y" : 331,
      "width" : 60,
      "height" : 30
    },
    "textPosition" : {
      "x" : 855,
      "y" : 335
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 906,
          "y" : 336
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 906,
          "y" : 336
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103148,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 877,
          "y" : 364
        },
        "to" : {
          "x" : 871,
          "y" : 391
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 879,
          "y" : 372
        },
        "b" : {
          "x" : 877,
          "y" : 364
        },
        "c" : {
          "x" : 872,
          "y" : 370
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 872,
          "y" : 370
        }
      }
    } ]
  }, {
    "id" : 103157,
    "reactomeId" : 5357694,
    "displayName" : "MeSeO2H",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1271,
      "y" : 232
    },
    "minX" : 1167,
    "maxX" : 1309,
    "minY" : 201,
    "maxY" : 247,
    "prop" : {
      "x" : 1235,
      "y" : 217,
      "width" : 73,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1237,
      "y" : 221
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1303,
          "y" : 222
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1303,
          "y" : 222
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103156,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1232,
          "y" : 221
        },
        "to" : {
          "x" : 1167,
          "y" : 201
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 103159,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1171,
      "y" : 273
    },
    "minX" : 1153,
    "maxX" : 1190,
    "minY" : 201,
    "maxY" : 288,
    "prop" : {
      "x" : 1153,
      "y" : 258,
      "width" : 36,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1157,
      "y" : 262
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1184,
          "y" : 263
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1184,
          "y" : 263
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103156,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1170,
          "y" : 255
        },
        "to" : {
          "x" : 1167,
          "y" : 201
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 103158,
    "reactomeId" : 29364,
    "displayName" : "NADPH",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1236,
      "y" : 149
    },
    "minX" : 1167,
    "maxX" : 1267,
    "minY" : 133,
    "maxY" : 201,
    "prop" : {
      "x" : 1207,
      "y" : 134,
      "width" : 59,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1211,
      "y" : 138
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1261,
          "y" : 139
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1261,
          "y" : 139
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103156,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1216,
          "y" : 167
        },
        "to" : {
          "x" : 1167,
          "y" : 201
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 103161,
    "reactomeId" : 29366,
    "displayName" : "NADP+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1010,
      "y" : 163
    },
    "minX" : 980,
    "maxX" : 1088,
    "minY" : 147,
    "maxY" : 200,
    "prop" : {
      "x" : 980,
      "y" : 148,
      "width" : 60,
      "height" : 30
    },
    "textPosition" : {
      "x" : 984,
      "y" : 152
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1035,
          "y" : 153
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1035,
          "y" : 153
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103156,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1043,
          "y" : 177
        },
        "to" : {
          "x" : 1088,
          "y" : 200
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1051,
          "y" : 177
        },
        "b" : {
          "x" : 1043,
          "y" : 177
        },
        "c" : {
          "x" : 1047,
          "y" : 184
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1047,
          "y" : 184
        }
      }
    } ]
  }, {
    "id" : 103160,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1102,
      "y" : 249
    },
    "minX" : 1081,
    "maxX" : 1125,
    "minY" : 200,
    "maxY" : 264,
    "prop" : {
      "x" : 1081,
      "y" : 234,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1085,
      "y" : 238
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1119,
          "y" : 239
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1119,
          "y" : 239
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103156,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1097,
          "y" : 231
        },
        "to" : {
          "x" : 1088,
          "y" : 200
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1091,
          "y" : 225
        },
        "b" : {
          "x" : 1097,
          "y" : 231
        },
        "c" : {
          "x" : 1099,
          "y" : 223
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1099,
          "y" : 223
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 103162,
    "reactomeId" : 10336634,
    "displayName" : "TNXRD1:FAD dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1127,
      "y" : 143
    },
    "minX" : 1089,
    "maxX" : 1172,
    "minY" : 119,
    "maxY" : 192,
    "prop" : {
      "x" : 1089,
      "y" : 125,
      "width" : 77,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1092,
      "y" : 127
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1166,
          "y" : 125
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1166,
          "y" : 125
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 103156,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1126,
          "y" : 165
        },
        "to" : {
          "x" : 1126,
          "y" : 184
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1126,
          "y" : 188
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1126,
          "y" : 188
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 103156,
    "reactomeId" : 10398936,
    "displayName" : "MeSeO2H is reduced to MeSeOH by TXNRD1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1126,
      "y" : 200
    },
    "minX" : 1088,
    "maxX" : 1167,
    "minY" : 194,
    "maxY" : 206,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1167,
        "y" : 201
      },
      "to" : {
        "x" : 1126,
        "y" : 200
      }
    }, {
      "from" : {
        "x" : 1126,
        "y" : 200
      },
      "to" : {
        "x" : 1088,
        "y" : 200
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1120,
        "y" : 194
      },
      "b" : {
        "x" : 1132,
        "y" : 206
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1126,
        "y" : 200
      }
    },
    "inputs" : [ {
      "id" : 103157,
      "points" : [ {
        "x" : 1232,
        "y" : 221
      } ]
    }, {
      "id" : 103158,
      "points" : [ {
        "x" : 1216,
        "y" : 167
      } ]
    }, {
      "id" : 103159,
      "points" : [ {
        "x" : 1170,
        "y" : 255
      } ]
    } ],
    "outputs" : [ {
      "id" : 103160,
      "points" : [ {
        "x" : 1097,
        "y" : 231
      } ]
    }, {
      "id" : 103150,
      "points" : [ {
        "x" : 1043,
        "y" : 214
      } ]
    }, {
      "id" : 103161,
      "points" : [ {
        "x" : 1043,
        "y" : 177
      } ]
    } ],
    "catalysts" : [ {
      "id" : 103162,
      "points" : [ {
        "x" : 1126,
        "y" : 165
      } ]
    } ]
  }, {
    "id" : 103140,
    "reactomeId" : 10388997,
    "displayName" : "Sec is reduced to H2Se by PXLP-K259-SCLY dimer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 713,
      "y" : 682
    },
    "minX" : 707,
    "maxX" : 723,
    "minY" : 644,
    "maxY" : 722,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 714,
        "y" : 722
      },
      "to" : {
        "x" : 713,
        "y" : 682
      }
    }, {
      "from" : {
        "x" : 713,
        "y" : 682
      },
      "to" : {
        "x" : 723,
        "y" : 644
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 707,
        "y" : 676
      },
      "b" : {
        "x" : 719,
        "y" : 688
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 713,
        "y" : 682
      }
    },
    "inputs" : [ {
      "id" : 103141,
      "points" : [ {
        "x" : 699,
        "y" : 726
      } ]
    }, {
      "id" : 103142,
      "points" : [ {
        "x" : 718,
        "y" : 750
      } ]
    } ],
    "outputs" : [ {
      "id" : 103143,
      "points" : [ {
        "x" : 685,
        "y" : 654
      } ]
    }, {
      "id" : 103144,
      "points" : [ {
        "x" : 645,
        "y" : 634
      } ]
    }, {
      "id" : 103145,
      "points" : [ {
        "x" : 736,
        "y" : 607
      } ]
    }, {
      "id" : 103146,
      "points" : [ {
        "x" : 691,
        "y" : 623
      } ]
    } ],
    "catalysts" : [ {
      "id" : 103147,
      "points" : [ {
        "x" : 605,
        "y" : 686
      } ]
    } ]
  }, {
    "id" : 103132,
    "reactomeId" : 10389000,
    "displayName" : "SeMet is converted to AdoSeMet by MAT",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 441,
      "y" : 309
    },
    "minX" : 435,
    "maxX" : 447,
    "minY" : 244,
    "maxY" : 402,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 440,
        "y" : 244
      },
      "to" : {
        "x" : 441,
        "y" : 309
      }
    }, {
      "from" : {
        "x" : 441,
        "y" : 309
      },
      "to" : {
        "x" : 443,
        "y" : 402
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 435,
        "y" : 303
      },
      "b" : {
        "x" : 447,
        "y" : 315
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 441,
        "y" : 309
      }
    },
    "inputs" : [ {
      "id" : 103133,
      "points" : [ {
        "x" : 582,
        "y" : 203
      } ]
    }, {
      "id" : 103134,
      "points" : [ {
        "x" : 362,
        "y" : 214
      } ]
    }, {
      "id" : 103135,
      "points" : [ {
        "x" : 442,
        "y" : 203
      } ]
    } ],
    "outputs" : [ {
      "id" : 103136,
      "points" : [ {
        "x" : 368,
        "y" : 440
      } ]
    }, {
      "id" : 103137,
      "points" : [ {
        "x" : 509,
        "y" : 467
      } ]
    }, {
      "id" : 103138,
      "points" : [ {
        "x" : 459,
        "y" : 477
      } ]
    } ],
    "catalysts" : [ {
      "id" : 103139,
      "points" : [ {
        "x" : 479,
        "y" : 307
      } ]
    } ]
  }, {
    "id" : 103148,
    "reactomeId" : 10398933,
    "displayName" : "MeSeOH is reduced to MeSeH by TXNRD1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 950,
      "y" : 353
    },
    "minX" : 871,
    "maxX" : 956,
    "minY" : 262,
    "maxY" : 391,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 950,
        "y" : 262
      },
      "to" : {
        "x" : 950,
        "y" : 353
      }
    }, {
      "from" : {
        "x" : 950,
        "y" : 353
      },
      "to" : {
        "x" : 871,
        "y" : 391
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 944,
        "y" : 347
      },
      "b" : {
        "x" : 956,
        "y" : 359
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 950,
        "y" : 353
      }
    },
    "inputs" : [ {
      "id" : 103149,
      "points" : [ {
        "x" : 922,
        "y" : 248
      } ]
    }, {
      "id" : 103150,
      "points" : [ {
        "x" : 984,
        "y" : 242
      } ]
    }, {
      "id" : 103151,
      "points" : [ {
        "x" : 947,
        "y" : 212
      } ]
    } ],
    "outputs" : [ {
      "id" : 103152,
      "points" : [ {
        "x" : 759,
        "y" : 414
      } ]
    }, {
      "id" : 103153,
      "points" : [ {
        "x" : 933,
        "y" : 388
      } ]
    }, {
      "id" : 103154,
      "points" : [ {
        "x" : 877,
        "y" : 364
      } ]
    } ],
    "catalysts" : [ {
      "id" : 103155,
      "points" : [ {
        "x" : 906,
        "y" : 321
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 103163,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 888,
      "y" : 749
    },
    "minX" : 0,
    "maxX" : 1776,
    "minY" : 0,
    "maxY" : 1499,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1776,
      "height" : 1499
    },
    "textPosition" : {
      "x" : 19,
      "y" : 1452
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1756,
      "height" : 1479
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 103133, 103152, 103132, 103134, 103135, 103136, 103137, 103139, 103138, 103142, 103140, 103143, 103145, 103147, 103148, 103149, 103150, 103151, 103153, 103154, 103155, 103156, 103160, 103161, 103162, 103157, 103158, 103159, 103141, 103144, 103146 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ {
    "id" : 103165,
    "reactomeId" : 10445448,
    "displayName" : "Metabolism of ingested MeSeO2H into MeSeH",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1004,
      "y" : 280
    },
    "minX" : 690,
    "maxX" : 1318,
    "minY" : 115,
    "maxY" : 445,
    "prop" : {
      "x" : 782,
      "y" : 160,
      "width" : 536,
      "height" : 285
    },
    "points" : [ {
      "x" : 690,
      "y" : 115
    }, {
      "x" : 1318,
      "y" : 115
    }, {
      "x" : 1318,
      "y" : 445
    }, {
      "x" : 690,
      "y" : 445
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 103164,
    "reactomeId" : 10445258,
    "displayName" : "Metabolism of ingested SeMet, Sec, MeSec into H2Se",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 538,
      "y" : 476
    },
    "minX" : 294,
    "maxX" : 782,
    "minY" : 160,
    "maxY" : 793,
    "prop" : {
      "x" : 294,
      "y" : 445,
      "width" : 488,
      "height" : 348
    },
    "points" : [ {
      "x" : 294,
      "y" : 160
    }, {
      "x" : 782,
      "y" : 160
    }, {
      "x" : 782,
      "y" : 793
    }, {
      "x" : 294,
      "y" : 793
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 1776,
  "minY" : 0,
  "maxY" : 1499,
  "disease" : false
}