{
  "dbId" : 10443750,
  "stId" : "R-BTA-1502540",
  "speciesName" : "Bos taurus",
  "nodes" : [ {
    "dbId" : 10378655,
    "stId" : "R-BTA-2470475",
    "displayName" : "Activin AB,B:ACVR2A,B:p-ACVR1C [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 24538 ],
    "parents" : [ 10378657 ],
    "children" : [ 10375041, 10378644, 10378653 ]
  }, {
    "dbId" : 10345884,
    "stId" : "R-BTA-171172",
    "displayName" : "SMAD2,3 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 24520 ],
    "parents" : [ ],
    "children" : [ 10345878, 10345882 ]
  }, {
    "dbId" : 10378653,
    "stId" : "R-BTA-1181110",
    "displayName" : "phospho-p-T175,S177,S179,S181,T194-ACVR1C [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MMW7",
    "standardIdentifier" : "uniprot:F1MMW7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10378655 ],
    "children" : [ ]
  }, {
    "dbId" : 10345882,
    "stId" : "R-BTA-170855",
    "displayName" : "SMAD3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MUZ3",
    "standardIdentifier" : "uniprot:F1MUZ3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SMAD3" ],
    "parents" : [ 10345884 ],
    "children" : [ ]
  }, {
    "dbId" : 10378644,
    "stId" : "R-BTA-2470478",
    "displayName" : "Activin AB,B [extracellular region]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "parents" : [ 10378655 ],
    "children" : [ 10375043, 10357476 ]
  }, {
    "dbId" : 10345878,
    "stId" : "R-BTA-3006353",
    "displayName" : "SMAD2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BE92",
    "standardIdentifier" : "uniprot:E1BE92",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SMAD2" ],
    "parents" : [ 10345884 ],
    "children" : [ ]
  }, {
    "dbId" : 10375057,
    "stId" : "R-BTA-1549500",
    "displayName" : "Activin A,AB,B:ACVR2A,B:p-ACVR1B [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 24517 ],
    "parents" : [ 10378657 ],
    "children" : [ 10375041, 10375045, 10375055 ]
  }, {
    "dbId" : 10351756,
    "stId" : "R-BTA-9839343",
    "displayName" : "INHIBIN-A:TGFBR3:ACVR2A [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 24514 ],
    "parents" : [ ],
    "children" : [ 10351681, 10351754 ]
  }, {
    "dbId" : 10375055,
    "stId" : "R-BTA-205780",
    "displayName" : "phospho-p-4S,T188,T206-ACVR1B [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MSQ2",
    "standardIdentifier" : "uniprot:F1MSQ2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10375057 ],
    "children" : [ ]
  }, {
    "dbId" : 10351752,
    "stId" : "R-BTA-9839337",
    "displayName" : "INHIBIN-A [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10351754 ],
    "children" : [ 10351746, 10351750 ]
  }, {
    "dbId" : 10351754,
    "stId" : "R-BTA-9839340",
    "displayName" : "INHIBIN-A:TGFBR3 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10351756 ],
    "children" : [ 10351752, 10345919 ]
  }, {
    "dbId" : 10375047,
    "stId" : "R-BTA-1549493",
    "displayName" : "Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 24513 ],
    "parents" : [ ],
    "children" : [ 10375041, 10375045, 10375039 ]
  }, {
    "dbId" : 10375045,
    "stId" : "R-BTA-2470494",
    "displayName" : "Activin A,AB,B [extracellular region]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 24511 ],
    "parents" : [ 10389635, 10375047, 10375057 ],
    "children" : [ 10375043, 10357474, 10357476 ]
  }, {
    "dbId" : 10351750,
    "stId" : "R-BTA-205926",
    "displayName" : "INHBA [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P07995",
    "standardIdentifier" : "uniprot:P07995",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "INHBA" ],
    "parents" : [ 10351752, 10375043, 10357474 ],
    "children" : [ ]
  }, {
    "dbId" : 10375043,
    "stId" : "R-BTA-2470491",
    "displayName" : "INHBA:INHBB [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10378644, 10375045 ],
    "children" : [ 10351750, 10357460 ]
  }, {
    "dbId" : 10389635,
    "stId" : "R-BTA-2473196",
    "displayName" : "Activin A,AB,B:FST [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 24527 ],
    "parents" : [ ],
    "children" : [ 10389633, 10375045 ]
  }, {
    "dbId" : 10375041,
    "stId" : "R-BTA-1181136",
    "displayName" : "ACVR2A,B [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 24512 ],
    "parents" : [ 10375047, 10378655, 10375057 ],
    "children" : [ 10351681, 10351685 ]
  }, {
    "dbId" : 10351746,
    "stId" : "R-BTA-1449702",
    "displayName" : "INHA [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P07994",
    "standardIdentifier" : "uniprot:P07994",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "INHA" ],
    "parents" : [ 10351752 ],
    "children" : [ ]
  }, {
    "dbId" : 10389633,
    "stId" : "R-BTA-2473211",
    "displayName" : "FST [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 24526 ],
    "identifier" : "P50291",
    "standardIdentifier" : "uniprot:P50291",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FST" ],
    "parents" : [ 10389635 ],
    "children" : [ ]
  }, {
    "dbId" : 10345919,
    "stId" : "R-BTA-9839336",
    "displayName" : "TGFBR3 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1B9H5",
    "standardIdentifier" : "uniprot:E1B9H5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TGFBR3" ],
    "parents" : [ 10351754 ],
    "children" : [ ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 24516, 24521 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10346148,
    "stId" : "R-BTA-1268261",
    "displayName" : "p-T,Y MAPK dimers [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 24533 ],
    "parents" : [ ],
    "children" : [ 10346146, 10346144 ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 24518, 24523 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10346144,
    "stId" : "R-BTA-109844",
    "displayName" : "p-T202, Y204 MAPK3 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10346148 ],
    "children" : [ 10340167 ]
  }, {
    "dbId" : 10378657,
    "stId" : "R-BTA-2470484",
    "displayName" : "Activin:ACVR2A,B:p-ACVR1B,C [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 24524 ],
    "parents" : [ ],
    "children" : [ 10375057, 10378655 ]
  }, {
    "dbId" : 10346146,
    "stId" : "R-BTA-109855",
    "displayName" : "p-T185,Y187 MAPK1 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10346148 ],
    "children" : [ 10340687 ]
  }, {
    "dbId" : 10345948,
    "stId" : "R-BTA-206866",
    "displayName" : "p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10345954 ],
    "children" : [ 10345936, 10345940 ]
  }, {
    "dbId" : 10345950,
    "stId" : "R-BTA-9736926",
    "displayName" : "p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10345954 ],
    "children" : [ 10345936, 10345940, 10345944 ]
  }, {
    "dbId" : 10345944,
    "stId" : "R-BTA-171184",
    "displayName" : "phospho-SMAD3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MUZ3",
    "standardIdentifier" : "uniprot:F1MUZ3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SMAD3" ],
    "parents" : [ 10345946, 10345950, 10345952 ],
    "children" : [ ]
  }, {
    "dbId" : 10345946,
    "stId" : "R-BTA-171182",
    "displayName" : "p-2S-SMAD2,3 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 24522 ],
    "parents" : [ ],
    "children" : [ 10345940, 10345944 ]
  }, {
    "dbId" : 10345940,
    "stId" : "R-BTA-3009186",
    "displayName" : "phospho-SMAD2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BE92",
    "standardIdentifier" : "uniprot:E1BE92",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SMAD2" ],
    "parents" : [ 10345946, 10345950, 10345948 ],
    "children" : [ ]
  }, {
    "dbId" : 10357460,
    "stId" : "R-BTA-1449664",
    "displayName" : "INHBB [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1LMU4",
    "standardIdentifier" : "uniprot:A0A3Q1LMU4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "INHBB" ],
    "parents" : [ 10357476, 10375043 ],
    "children" : [ ]
  }, {
    "dbId" : 10345936,
    "stId" : "R-BTA-170862",
    "displayName" : "SMAD4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 24529 ],
    "identifier" : "B0JYL0",
    "standardIdentifier" : "uniprot:B0JYL0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SMAD4" ],
    "parents" : [ 10345950, 10345952, 10345948 ],
    "children" : [ ]
  }, {
    "dbId" : 10340687,
    "stId" : "R-BTA-109853",
    "displayName" : "phospho-p-T185,Y187-MAPK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P46196",
    "standardIdentifier" : "uniprot:P46196",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10346146 ],
    "children" : [ ]
  }, {
    "dbId" : 10351685,
    "stId" : "R-BTA-201656",
    "displayName" : "ACVR2B [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1MGJ6",
    "standardIdentifier" : "uniprot:A0A3Q1MGJ6",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10375041 ],
    "children" : [ ]
  }, {
    "dbId" : 10340167,
    "stId" : "R-BTA-109842",
    "displayName" : "phospho-p-T202,Y204-MAPK3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1B8P9",
    "standardIdentifier" : "uniprot:E1B8P9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10346144 ],
    "children" : [ ]
  }, {
    "dbId" : 10351681,
    "stId" : "R-BTA-201659",
    "displayName" : "ACVR2A [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q28043",
    "standardIdentifier" : "uniprot:Q28043",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10351756, 10375041 ],
    "children" : [ ]
  }, {
    "dbId" : 10375039,
    "stId" : "R-BTA-205867",
    "displayName" : "ACVR1B [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 24510 ],
    "identifier" : "F1MSQ2",
    "standardIdentifier" : "uniprot:F1MSQ2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10375047 ],
    "children" : [ ]
  }, {
    "dbId" : 10346104,
    "stId" : "R-BTA-9736929",
    "displayName" : "p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10346106 ],
    "children" : [ 10346096, 10346100, 10346094 ]
  }, {
    "dbId" : 10346106,
    "stId" : "R-BTA-173511",
    "displayName" : "p-2S-SMAD2,3:SMAD4 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 24532 ],
    "parents" : [ ],
    "children" : [ 10346098, 10346102, 10346104 ]
  }, {
    "dbId" : 10346100,
    "stId" : "R-BTA-3009185",
    "displayName" : "phospho-SMAD2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BE92",
    "standardIdentifier" : "uniprot:E1BE92",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SMAD2" ],
    "parents" : [ 10346104, 10346102 ],
    "children" : [ ]
  }, {
    "dbId" : 10346102,
    "stId" : "R-BTA-206827",
    "displayName" : "p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10346106 ],
    "children" : [ 10346096, 10346100 ]
  }, {
    "dbId" : 10346096,
    "stId" : "R-BTA-177103",
    "displayName" : "SMAD4 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "B0JYL0",
    "standardIdentifier" : "uniprot:B0JYL0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SMAD4" ],
    "parents" : [ 10346098, 10346104, 10346102 ],
    "children" : [ ]
  }, {
    "dbId" : 10346098,
    "stId" : "R-BTA-8878153",
    "displayName" : "p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10346106 ],
    "children" : [ 10346096, 10346094 ]
  }, {
    "dbId" : 10346094,
    "stId" : "R-BTA-177104",
    "displayName" : "phospho-SMAD3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MUZ3",
    "standardIdentifier" : "uniprot:F1MUZ3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SMAD3" ],
    "parents" : [ 10346098, 10346104 ],
    "children" : [ ]
  }, {
    "dbId" : 10357476,
    "stId" : "R-BTA-1449672",
    "displayName" : "INHBB dimer [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10378644, 10375045 ],
    "children" : [ 10357460 ]
  }, {
    "dbId" : 10357474,
    "stId" : "R-BTA-206893",
    "displayName" : "INHBA dimer [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10375045 ],
    "children" : [ 10351750 ]
  }, {
    "dbId" : 10443746,
    "stId" : "R-BTA-2173793",
    "displayName" : "Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer",
    "schemaClass" : "Pathway",
    "speciesId" : 48898,
    "diagramIds" : [ 24540 ]
  }, {
    "dbId" : 10345952,
    "stId" : "R-BTA-9736931",
    "displayName" : "p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10345954 ],
    "children" : [ 10345936, 10345944 ]
  }, {
    "dbId" : 10345954,
    "stId" : "R-BTA-171175",
    "displayName" : "p-2S-SMAD2,3:SMAD4 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 24530 ],
    "parents" : [ ],
    "children" : [ 10345952, 10345950, 10345948 ]
  } ],
  "edges" : [ {
    "dbId" : 10375062,
    "stId" : "R-BTA-1181153",
    "displayName" : "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10375060 ],
    "inputs" : [ 10375041, 10375045, 10375039 ],
    "outputs" : [ 10375047 ],
    "efs" : [ ],
    "inhibitors" : [ 10351756 ],
    "diagramIds" : [ 24509 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10378662,
    "stId" : "R-BTA-1549526",
    "displayName" : "Phosphorylation of SMAD2,3 by Activin:Activin Receptor",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10375060 ],
    "following" : [ 10345956 ],
    "inputs" : [ 113592, 10345884 ],
    "outputs" : [ 29370, 10345946 ],
    "catalysts" : [ 10378657 ],
    "efs" : [ ],
    "diagramIds" : [ 24519 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10345956,
    "stId" : "R-BTA-170847",
    "displayName" : "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10378662 ],
    "following" : [ 10346150 ],
    "inputs" : [ 10345936, 10345946 ],
    "outputs" : [ 10345954 ],
    "efs" : [ ],
    "diagramIds" : [ 24528 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10375060,
    "stId" : "R-BTA-1181149",
    "displayName" : "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10375062 ],
    "following" : [ 10378662 ],
    "inputs" : [ 10375047, 113592 ],
    "outputs" : [ 10375057, 29370 ],
    "catalysts" : [ 10375047 ],
    "efs" : [ ],
    "diagramIds" : [ 24515 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10346150,
    "stId" : "R-BTA-173488",
    "displayName" : "The SMAD2/3:SMAD4 complex transfers to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10345956 ],
    "inputs" : [ 10345954 ],
    "outputs" : [ 10346106 ],
    "efs" : [ ],
    "inhibitors" : [ 10346148 ],
    "diagramIds" : [ 24531 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10389637,
    "stId" : "R-BTA-2473184",
    "displayName" : "Follistatin (FST) binds Activin",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10389633, 10375045 ],
    "outputs" : [ 10389635 ],
    "efs" : [ ],
    "diagramIds" : [ 24525 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10445268,
    "stId" : "R-BTA-2473224",
    "displayName" : "Antagonism of Activin by Follistatin",
    "events" : [ 10389637 ]
  } ]
}