{ "dbId" : 11128762, "stableId" : "R-PFA-983231", "displayName" : "Factors involved in megakaryocyte development and platelet production", "nodes" : [ { "id" : 41521, "reactomeId" : 113573, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1579, "y" : 132 }, "minX" : 1561, "maxX" : 1626, "minY" : 117, "maxY" : 159, "prop" : { "x" : 1561, "y" : 118, "width" : 37, "height" : 29 }, "textPosition" : { "x" : 1563, "y" : 122 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1593, "y" : 123 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1593, "y" : 123 } } }, "connectors" : [ { "edgeId" : 41520, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1601, "y" : 142 }, "to" : { "x" : 1626, "y" : 159 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 41522, "reactomeId" : 159448, "displayName" : "AMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1568, "y" : 206 }, "minX" : 1513, "maxX" : 1626, "minY" : 159, "maxY" : 228, "prop" : { "x" : 1513, "y" : 184, "width" : 110, "height" : 44 }, "textPosition" : { "x" : 1551, "y" : 195 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1618, "y" : 189 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1618, "y" : 189 } } }, "connectors" : [ { "edgeId" : 41520, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1595, "y" : 181 }, "to" : { "x" : 1626, "y" : 159 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 41523, "reactomeId" : 113581, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1749, "y" : 140 }, "minX" : 1693, "maxX" : 1770, "minY" : 125, "maxY" : 161, "prop" : { "x" : 1730, "y" : 126, "width" : 39, "height" : 29 }, "textPosition" : { "x" : 1733, "y" : 130 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1764, "y" : 131 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1764, "y" : 131 } } }, "connectors" : [ { "edgeId" : 41520, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1727, "y" : 147 }, "to" : { "x" : 1693, "y" : 161 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1722, "y" : 153 }, "b" : { "x" : 1727, "y" : 147 }, "c" : { "x" : 1719, "y" : 146 }, "type" : "ARROW", "centre" : { "x" : 1719, "y" : 146 } } } ] }, { "id" : 41524, "reactomeId" : 113525, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1747, "y" : 196 }, "minX" : 1693, "maxX" : 1768, "minY" : 161, "maxY" : 211, "prop" : { "x" : 1728, "y" : 182, "width" : 39, "height" : 29 }, "textPosition" : { "x" : 1730, "y" : 186 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1762, "y" : 187 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1762, "y" : 187 } } }, "connectors" : [ { "edgeId" : 41520, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1725, "y" : 183 }, "to" : { "x" : 1693, "y" : 161 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1717, "y" : 182 }, "b" : { "x" : 1725, "y" : 183 }, "c" : { "x" : 1722, "y" : 176 }, "type" : "ARROW", "centre" : { "x" : 1722, "y" : 176 } } } ] }, { "id" : 41541, "reactomeId" : 11128760, "displayName" : "Kinesins", "schemaClass" : "Pathway", "renderableClass" : "ProcessNode", "position" : { "x" : 1972, "y" : 362 }, "minX" : 1913, "maxX" : 2031, "minY" : 330, "maxY" : 395, "prop" : { "x" : 1913, "y" : 330, "width" : 118, "height" : 65 }, "textPosition" : { "x" : 1938, "y" : 348 }, "connectors" : [ ] }, { "id" : 41525, "reactomeId" : 11115647, "displayName" : "AKLP2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1667, "y" : 109 }, "minX" : 1640, "maxX" : 1700, "minY" : 93, "maxY" : 153, "prop" : { "x" : 1640, "y" : 99, "width" : 54, "height" : 20 }, "textPosition" : { "x" : 1644, "y" : 99 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1694, "y" : 99 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1694, "y" : 99 } } }, "connectors" : [ { "edgeId" : 41520, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1667, "y" : 122 }, "to" : { "x" : 1667, "y" : 145 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1667, "y" : 149 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1667, "y" : 149 } } } ] }, { "id" : 41513, "reactomeId" : 11115618, "displayName" : "CBX5", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 155, "y" : 514 }, "minX" : 125, "maxX" : 223, "minY" : 496, "maxY" : 554, "prop" : { "x" : 125, "y" : 502, "width" : 60, "height" : 25 }, "textPosition" : { "x" : 135, "y" : 504 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 185, "y" : 502 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 185, "y" : 502 } } }, "connectors" : [ { "edgeId" : 41512, "type" : "INPUT", "segments" : [ { "from" : { "x" : 176, "y" : 530 }, "to" : { "x" : 223, "y" : 554 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 41514, "reactomeId" : 11115626, "displayName" : "Histone H3 methylated at lysine-9", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 146, "y" : 588 }, "minX" : 101, "maxX" : 223, "minY" : 554, "maxY" : 613, "prop" : { "x" : 101, "y" : 564, "width" : 91, "height" : 49 }, "textPosition" : { "x" : 105, "y" : 564 }, "connectors" : [ { "edgeId" : 41512, "type" : "INPUT", "segments" : [ { "from" : { "x" : 198, "y" : 567 }, "to" : { "x" : 223, "y" : 554 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 41515, "reactomeId" : 11115628, "displayName" : "HP1alpha:Histone H3 methylated at K9", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 377, "y" : 551 }, "minX" : 314, "maxX" : 447, "minY" : 520, "maxY" : 577, "prop" : { "x" : 314, "y" : 526, "width" : 127, "height" : 51 }, "textPosition" : { "x" : 315, "y" : 528 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 441, "y" : 526 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 441, "y" : 526 } } }, "connectors" : [ { "edgeId" : 41512, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 41517, "reactomeId" : 11115632, "displayName" : "Histone H3 mono or di-methylated at K9", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 146, "y" : 663 }, "minX" : 80, "maxX" : 213, "minY" : 643, "maxY" : 684, "prop" : { "x" : 80, "y" : 643, "width" : 133, "height" : 41 }, "textPosition" : { "x" : 78, "y" : 646 }, "connectors" : [ { "edgeId" : 41516, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 41518, "reactomeId" : 11115634, "displayName" : "Histone H3 mono- or unmethylated at K9", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 337, "y" : 663 }, "minX" : 269, "maxX" : 406, "minY" : 642, "maxY" : 684, "prop" : { "x" : 269, "y" : 642, "width" : 137, "height" : 42 }, "textPosition" : { "x" : 267, "y" : 645 }, "connectors" : [ { "edgeId" : 41516, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 41519, "reactomeId" : 11115639, "displayName" : "JMJD1C", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 239, "y" : 720 }, "minX" : 201, "maxX" : 283, "minY" : 671, "maxY" : 732, "prop" : { "x" : 201, "y" : 709, "width" : 76, "height" : 23 }, "textPosition" : { "x" : 214, "y" : 710 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 277, "y" : 709 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 277, "y" : 709 } } }, "connectors" : [ { "edgeId" : 41516, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 239, "y" : 706 }, "to" : { "x" : 239, "y" : 679 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 239, "y" : 675 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 239, "y" : 675 } } } ] } ], "edges" : [ { "id" : 41520, "reactomeId" : 11115650, "displayName" : "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1667, "y" : 161 }, "minX" : 1626, "maxX" : 1693, "minY" : 155, "maxY" : 167, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1626, "y" : 159 }, "to" : { "x" : 1667, "y" : 161 } }, { "from" : { "x" : 1667, "y" : 161 }, "to" : { "x" : 1693, "y" : 161 } } ], "reactionShape" : { "a" : { "x" : 1661, "y" : 155 }, "b" : { "x" : 1673, "y" : 167 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1667, "y" : 161 } }, "inputs" : [ { "id" : 41521, "points" : [ { "x" : 1601, "y" : 142 } ] }, { "id" : 41522, "points" : [ { "x" : 1595, "y" : 181 } ] } ], "outputs" : [ { "id" : 41523, "points" : [ { "x" : 1727, "y" : 147 } ] }, { "id" : 41524, "points" : [ { "x" : 1725, "y" : 183 } ] } ], "catalysts" : [ { "id" : 41525, "points" : [ { "x" : 1667, "y" : 122 } ] } ] }, { "id" : 41512, "reactomeId" : 11115630, "displayName" : "HP1 alpha binds Histone H3K9(me)3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 251, "y" : 553 }, "minX" : 223, "maxX" : 311, "minY" : 547, "maxY" : 559, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 223, "y" : 554 }, "to" : { "x" : 251, "y" : 553 } }, { "from" : { "x" : 251, "y" : 553 }, "to" : { "x" : 311, "y" : 552 } } ], "endShape" : { "a" : { "x" : 304, "y" : 556 }, "b" : { "x" : 311, "y" : 552 }, "c" : { "x" : 304, "y" : 548 }, "type" : "ARROW", "centre" : { "x" : 304, "y" : 548 } }, "reactionShape" : { "c" : { "x" : 251, "y" : 553 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 251, "y" : 553 } }, "inputs" : [ { "id" : 41513, "points" : [ { "x" : 176, "y" : 530 } ] }, { "id" : 41514, "points" : [ { "x" : 198, "y" : 567 } ] } ], "outputs" : [ { "id" : 41515 } ] }, { "id" : 41516, "reactomeId" : 11115642, "displayName" : "JMJD1C demethylates H3K9 mono- and di-methylation", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 239, "y" : 663 }, "minX" : 219, "maxX" : 263, "minY" : 657, "maxY" : 669, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 219, "y" : 663 }, "to" : { "x" : 239, "y" : 663 } }, { "from" : { "x" : 239, "y" : 663 }, "to" : { "x" : 263, "y" : 663 } } ], "endShape" : { "a" : { "x" : 256, "y" : 667 }, "b" : { "x" : 263, "y" : 663 }, "c" : { "x" : 256, "y" : 659 }, "type" : "ARROW", "centre" : { "x" : 256, "y" : 659 } }, "reactionShape" : { "a" : { "x" : 233, "y" : 657 }, "b" : { "x" : 245, "y" : 669 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 239, "y" : 663 } }, "inputs" : [ { "id" : 41517 } ], "outputs" : [ { "id" : 41518 } ], "catalysts" : [ { "id" : 41519, "points" : [ { "x" : 239, "y" : 706 } ] } ] } ], "compartments" : [ { "id" : 41538, "reactomeId" : 171907, "displayName" : "endosome lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1277, "y" : 237 }, "minX" : 1085, "maxX" : 1469, "minY" : 53, "maxY" : 421, "prop" : { "x" : 1085, "y" : 53, "width" : 384, "height" : 368 }, "textPosition" : { "x" : 1347, "y" : 384 }, "insets" : { "x" : 1095, "y" : 63, "width" : 364, "height" : 348 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 41527, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 532, "y" : 499 }, "minX" : 34, "maxX" : 1030, "minY" : 28, "maxY" : 971, "prop" : { "x" : 34, "y" : 28, "width" : 996, "height" : 943 }, "textPosition" : { "x" : 915, "y" : 920 }, "insets" : { "x" : 44, "y" : 38, "width" : 976, "height" : 923 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 41512, 41513, 41514, 41515, 41516, 41517, 41518, 41519, 41550, 41551, 41552, 41553, 41554 ] }, { "id" : 41530, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1106, "y" : 505 }, "minX" : 0, "maxX" : 2213, "minY" : 0, "maxY" : 1010, "prop" : { "x" : 0, "y" : 0, "width" : 2213, "height" : 1010 }, "textPosition" : { "x" : 1302, "y" : 935 }, "insets" : { "x" : 10, "y" : 10, "width" : 2193, "height" : 990 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 41527, 41531, 41538, 41541 ] }, { "id" : 41531, "reactomeId" : 5460, "displayName" : "mitochondrial matrix", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1643, "y" : 161 }, "minX" : 1490, "maxX" : 1796, "minY" : 74, "maxY" : 249, "prop" : { "x" : 1490, "y" : 74, "width" : 306, "height" : 175 }, "textPosition" : { "x" : 1648, "y" : 213 }, "insets" : { "x" : 1500, "y" : 84, "width" : 286, "height" : 155 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 41520, 41521, 41522, 41523, 41524, 41525 ] } ], "notes" : [ ], "links" : [ { "id" : 41552, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 241, "y" : 663 }, "minX" : 219, "maxX" : 263, "minY" : 657, "maxY" : 669, "segments" : [ { "from" : { "x" : 263, "y" : 663 }, "to" : { "x" : 219, "y" : 663 } } ], "reactionShape" : { "a" : { "x" : 235, "y" : 657 }, "b" : { "x" : 247, "y" : 669 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 241, "y" : 663 } }, "inputs" : [ { "id" : 41518 } ], "outputs" : [ { "id" : 41517 } ] }, { "id" : 41550, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 145, "y" : 628 }, "minX" : 139, "maxX" : 151, "minY" : 619, "maxY" : 637, "segments" : [ { "from" : { "x" : 145, "y" : 619 }, "to" : { "x" : 145, "y" : 637 } } ], "reactionShape" : { "a" : { "x" : 139, "y" : 622 }, "b" : { "x" : 151, "y" : 634 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 145, "y" : 628 } }, "inputs" : [ { "id" : 41514 } ], "outputs" : [ { "id" : 41517 } ] }, { "id" : 41551, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 243, "y" : 619 }, "minX" : 198, "maxX" : 288, "minY" : 603, "maxY" : 636, "segments" : [ { "from" : { "x" : 198, "y" : 603 }, "to" : { "x" : 288, "y" : 636 } } ], "reactionShape" : { "a" : { "x" : 237, "y" : 613 }, "b" : { "x" : 249, "y" : 625 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 243, "y" : 619 } }, "inputs" : [ { "id" : 41514 } ], "outputs" : [ { "id" : 41518 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 2213, "minY" : 0, "maxY" : 1010, "disease" : false }