{
  "dbId" : 11128684,
  "stableId" : "R-PFA-2559580",
  "displayName" : "Oxidative Stress Induced Senescence",
  "nodes" : [ {
    "id" : 50769,
    "reactomeId" : 11114346,
    "displayName" : "p-p38 MAPK: MAPKAPK2,3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 851,
      "y" : 532
    },
    "minX" : 784,
    "maxX" : 963,
    "minY" : 509,
    "maxY" : 550,
    "prop" : {
      "x" : 784,
      "y" : 515,
      "width" : 135,
      "height" : 35
    },
    "textPosition" : {
      "x" : 807,
      "y" : 515
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 919,
          "y" : 515
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 919,
          "y" : 515
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50768,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 922,
          "y" : 535
        },
        "to" : {
          "x" : 947,
          "y" : 537
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50768,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 922,
          "y" : 516
        },
        "to" : {
          "x" : 949,
          "y" : 510
        }
      }, {
        "from" : {
          "x" : 949,
          "y" : 510
        },
        "to" : {
          "x" : 957,
          "y" : 523
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 959,
          "y" : 527
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 959,
          "y" : 527
        }
      }
    } ]
  }, {
    "id" : 50801,
    "reactomeId" : 11128070,
    "displayName" : "Mitotic G1 phase and G1/S transition",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 323,
      "y" : 1422
    },
    "minX" : 227,
    "maxX" : 420,
    "minY" : 1397,
    "maxY" : 1448,
    "prop" : {
      "x" : 227,
      "y" : 1397,
      "width" : 193,
      "height" : 51
    },
    "textPosition" : {
      "x" : 230,
      "y" : 1401
    },
    "connectors" : [ ]
  }, {
    "id" : 50770,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 927,
      "y" : 581
    },
    "minX" : 906,
    "maxX" : 949,
    "minY" : 537,
    "maxY" : 591,
    "prop" : {
      "x" : 906,
      "y" : 571,
      "width" : 42,
      "height" : 20
    },
    "textPosition" : {
      "x" : 911,
      "y" : 571
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 943,
          "y" : 576
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 943,
          "y" : 576
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50768,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 931,
          "y" : 568
        },
        "to" : {
          "x" : 947,
          "y" : 537
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 933,
            "y" : 546
          },
          "b" : {
            "x" : 945,
            "y" : 558
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 939,
            "y" : 552
          }
        }
      }
    } ]
  }, {
    "id" : 50802,
    "reactomeId" : 11128374,
    "displayName" : "Intrinsic Pathway for Apoptosis",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1354,
      "y" : 717
    },
    "minX" : 1280,
    "maxX" : 1429,
    "minY" : 691,
    "maxY" : 744,
    "prop" : {
      "x" : 1280,
      "y" : 691,
      "width" : 149,
      "height" : 53
    },
    "textPosition" : {
      "x" : 1281,
      "y" : 696
    },
    "connectors" : [ ]
  }, {
    "id" : 50771,
    "reactomeId" : 11114370,
    "displayName" : "p-p38 MAPK:p-MAPKAPK2/3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1086,
      "y" : 545
    },
    "minX" : 986,
    "maxX" : 1158,
    "minY" : 520,
    "maxY" : 565,
    "prop" : {
      "x" : 1020,
      "y" : 526,
      "width" : 132,
      "height" : 39
    },
    "textPosition" : {
      "x" : 1037,
      "y" : 530
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1152,
          "y" : 526
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1152,
          "y" : 526
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50768,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1017,
          "y" : 539
        },
        "to" : {
          "x" : 986,
          "y" : 537
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1010,
          "y" : 543
        },
        "b" : {
          "x" : 1017,
          "y" : 539
        },
        "c" : {
          "x" : 1010,
          "y" : 535
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1010,
          "y" : 535
        }
      }
    } ]
  }, {
    "id" : 50772,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1000,
      "y" : 586
    },
    "minX" : 981,
    "maxX" : 1020,
    "minY" : 537,
    "maxY" : 598,
    "prop" : {
      "x" : 981,
      "y" : 575,
      "width" : 38,
      "height" : 23
    },
    "textPosition" : {
      "x" : 983,
      "y" : 576
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1014,
          "y" : 580
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1014,
          "y" : 580
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50768,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 996,
          "y" : 572
        },
        "to" : {
          "x" : 986,
          "y" : 537
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 985,
            "y" : 548
          },
          "b" : {
            "x" : 997,
            "y" : 560
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 991,
            "y" : 554
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 990,
          "y" : 566
        },
        "b" : {
          "x" : 996,
          "y" : 572
        },
        "c" : {
          "x" : 998,
          "y" : 564
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 998,
          "y" : 564
        }
      }
    } ]
  }, {
    "id" : 50774,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1123,
      "y" : 439
    },
    "minX" : 1102,
    "maxX" : 1145,
    "minY" : 428,
    "maxY" : 484,
    "prop" : {
      "x" : 1102,
      "y" : 429,
      "width" : 42,
      "height" : 20
    },
    "textPosition" : {
      "x" : 1107,
      "y" : 429
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1139,
          "y" : 434
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1139,
          "y" : 434
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50773,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1127,
          "y" : 452
        },
        "to" : {
          "x" : 1141,
          "y" : 484
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50775,
    "reactomeId" : 11117049,
    "displayName" : "phospho-p38 MAPK: MAPKAPK5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1036,
      "y" : 484
    },
    "minX" : 968,
    "maxX" : 1156,
    "minY" : 460,
    "maxY" : 506,
    "prop" : {
      "x" : 968,
      "y" : 466,
      "width" : 137,
      "height" : 36
    },
    "textPosition" : {
      "x" : 968,
      "y" : 467
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1105,
          "y" : 466
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1105,
          "y" : 466
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50773,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1108,
          "y" : 484
        },
        "to" : {
          "x" : 1141,
          "y" : 484
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50773,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1108,
          "y" : 497
        },
        "to" : {
          "x" : 1144,
          "y" : 506
        }
      }, {
        "from" : {
          "x" : 1144,
          "y" : 506
        },
        "to" : {
          "x" : 1150,
          "y" : 498
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1152,
          "y" : 495
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1152,
          "y" : 495
        }
      }
    } ]
  }, {
    "id" : 50776,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1198,
      "y" : 441
    },
    "minX" : 1174,
    "maxX" : 1220,
    "minY" : 431,
    "maxY" : 483,
    "prop" : {
      "x" : 1177,
      "y" : 432,
      "width" : 42,
      "height" : 18
    },
    "textPosition" : {
      "x" : 1181,
      "y" : 431
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1214,
          "y" : 437
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1214,
          "y" : 437
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50773,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1192,
          "y" : 453
        },
        "to" : {
          "x" : 1174,
          "y" : 483
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1192,
          "y" : 461
        },
        "b" : {
          "x" : 1192,
          "y" : 453
        },
        "c" : {
          "x" : 1185,
          "y" : 457
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1185,
          "y" : 457
        }
      }
    } ]
  }, {
    "id" : 50777,
    "reactomeId" : 11117077,
    "displayName" : "phospho-p38 MAPK:p-T-182-MAPKAPK5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1264,
      "y" : 490
    },
    "minX" : 1174,
    "maxX" : 1335,
    "minY" : 460,
    "maxY" : 515,
    "prop" : {
      "x" : 1199,
      "y" : 466,
      "width" : 130,
      "height" : 49
    },
    "textPosition" : {
      "x" : 1216,
      "y" : 466
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1329,
          "y" : 466
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1329,
          "y" : 466
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50773,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1196,
          "y" : 484
        },
        "to" : {
          "x" : 1174,
          "y" : 483
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1189,
          "y" : 488
        },
        "b" : {
          "x" : 1196,
          "y" : 484
        },
        "c" : {
          "x" : 1189,
          "y" : 480
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1189,
          "y" : 480
        }
      }
    } ]
  }, {
    "id" : 50811,
    "reactomeId" : 11129036,
    "displayName" : "Cell Cycle Checkpoints",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1356,
      "y" : 794
    },
    "minX" : 1275,
    "maxX" : 1438,
    "minY" : 768,
    "maxY" : 821,
    "prop" : {
      "x" : 1275,
      "y" : 768,
      "width" : 163,
      "height" : 53
    },
    "textPosition" : {
      "x" : 1279,
      "y" : 780
    },
    "connectors" : [ ]
  } ],
  "edges" : [ {
    "id" : 50768,
    "reactomeId" : 11114373,
    "displayName" : "Active p38 MAPK phosphorylates MAPKAPK2 or 3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 965,
      "y" : 537
    },
    "minX" : 947,
    "maxX" : 986,
    "minY" : 531,
    "maxY" : 543,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 947,
        "y" : 537
      },
      "to" : {
        "x" : 965,
        "y" : 537
      }
    }, {
      "from" : {
        "x" : 965,
        "y" : 537
      },
      "to" : {
        "x" : 986,
        "y" : 537
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 959,
        "y" : 531
      },
      "b" : {
        "x" : 971,
        "y" : 543
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 965,
        "y" : 537
      }
    },
    "inputs" : [ {
      "id" : 50769,
      "points" : [ {
        "x" : 922,
        "y" : 535
      } ]
    }, {
      "id" : 50770,
      "points" : [ {
        "x" : 931,
        "y" : 568
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 50771,
      "points" : [ {
        "x" : 1017,
        "y" : 539
      } ]
    }, {
      "id" : 50772,
      "points" : [ {
        "x" : 996,
        "y" : 572
      } ],
      "stoichiometry" : 3
    } ],
    "catalysts" : [ {
      "id" : 50769,
      "points" : [ {
        "x" : 922,
        "y" : 516
      }, {
        "x" : 949,
        "y" : 510
      } ]
    } ]
  }, {
    "id" : 50773,
    "reactomeId" : 11117080,
    "displayName" : "Active p38 MAPK phosphorylates MAPKAPK5",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1159,
      "y" : 485
    },
    "minX" : 1141,
    "maxX" : 1174,
    "minY" : 479,
    "maxY" : 491,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1141,
        "y" : 484
      },
      "to" : {
        "x" : 1159,
        "y" : 485
      }
    }, {
      "from" : {
        "x" : 1159,
        "y" : 485
      },
      "to" : {
        "x" : 1174,
        "y" : 483
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1153,
        "y" : 479
      },
      "b" : {
        "x" : 1165,
        "y" : 491
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1159,
        "y" : 485
      }
    },
    "inputs" : [ {
      "id" : 50774,
      "points" : [ {
        "x" : 1127,
        "y" : 452
      } ]
    }, {
      "id" : 50775,
      "points" : [ {
        "x" : 1108,
        "y" : 484
      } ]
    } ],
    "outputs" : [ {
      "id" : 50776,
      "points" : [ {
        "x" : 1192,
        "y" : 453
      } ]
    }, {
      "id" : 50777,
      "points" : [ {
        "x" : 1196,
        "y" : 484
      } ]
    } ],
    "catalysts" : [ {
      "id" : 50775,
      "points" : [ {
        "x" : 1108,
        "y" : 497
      }, {
        "x" : 1144,
        "y" : 506
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 50786,
    "reactomeId" : 5460,
    "displayName" : "mitochondrial matrix",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 190,
      "y" : 76
    },
    "minX" : 114,
    "maxX" : 267,
    "minY" : 45,
    "maxY" : 108,
    "prop" : {
      "x" : 114,
      "y" : 45,
      "width" : 153,
      "height" : 63
    },
    "textPosition" : {
      "x" : 113,
      "y" : 62
    },
    "insets" : {
      "x" : 124,
      "y" : 55,
      "width" : 133,
      "height" : 43
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 50778,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 733,
      "y" : 759
    },
    "minX" : 0,
    "maxX" : 1466,
    "minY" : 0,
    "maxY" : 1518,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1466,
      "height" : 1518
    },
    "textPosition" : {
      "x" : 53,
      "y" : 1188
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1446,
      "height" : 1498
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 50779, 50786, 50780, 50815, 50816, 50817, 50818, 50801, 50820, 50822, 50823, 50826, 50827 ]
  }, {
    "id" : 50779,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 720,
      "y" : 734
    },
    "minX" : 23,
    "maxX" : 1417,
    "minY" : 382,
    "maxY" : 1087,
    "prop" : {
      "x" : 23,
      "y" : 382,
      "width" : 1394,
      "height" : 705
    },
    "textPosition" : {
      "x" : 43,
      "y" : 756
    },
    "insets" : {
      "x" : 33,
      "y" : 392,
      "width" : 1374,
      "height" : 685
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 50769, 50768, 50770, 50771, 50772, 50819, 50802, 50821, 50775, 50773, 50774, 50776, 50777, 50824, 50811, 50825 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1466,
  "minY" : 0,
  "maxY" : 1518,
  "disease" : false
}