{
  "dbId" : 11128334,
  "stableId" : "R-PFA-442755",
  "displayName" : "Activation of NMDA receptors and postsynaptic events",
  "nodes" : [ {
    "id" : 63143,
    "reactomeId" : 11111464,
    "displayName" : "PKA tetramer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 947,
      "y" : 377
    },
    "minX" : 877,
    "maxX" : 996,
    "minY" : 360,
    "maxY" : 388,
    "prop" : {
      "x" : 904,
      "y" : 366,
      "width" : 86,
      "height" : 22
    },
    "textPosition" : {
      "x" : 915,
      "y" : 353
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 990,
          "y" : 366
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 990,
          "y" : 366
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 63142,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 901,
          "y" : 379
        },
        "to" : {
          "x" : 877,
          "y" : 381
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 63144,
    "reactomeId" : 30389,
    "displayName" : "cAMP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 829,
      "y" : 345
    },
    "minX" : 805,
    "maxX" : 877,
    "minY" : 329,
    "maxY" : 381,
    "prop" : {
      "x" : 805,
      "y" : 330,
      "width" : 48,
      "height" : 30
    },
    "textPosition" : {
      "x" : 808,
      "y" : 334
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 848,
          "y" : 335
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 848,
          "y" : 335
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 63142,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 849,
          "y" : 363
        },
        "to" : {
          "x" : 877,
          "y" : 381
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 857,
            "y" : 366
          },
          "b" : {
            "x" : 869,
            "y" : 378
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 863,
            "y" : 372
          }
        }
      }
    } ]
  }, {
    "id" : 63145,
    "reactomeId" : 11111466,
    "displayName" : "PKA tetramer:4xcAMP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 864,
      "y" : 451
    },
    "minX" : 798,
    "maxX" : 915,
    "minY" : 427,
    "maxY" : 469,
    "prop" : {
      "x" : 819,
      "y" : 433,
      "width" : 90,
      "height" : 36
    },
    "textPosition" : {
      "x" : 830,
      "y" : 420
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 909,
          "y" : 433
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 909,
          "y" : 433
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 63142,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 63146,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 63146,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 816,
          "y" : 438
        },
        "to" : {
          "x" : 805,
          "y" : 435
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 802,
          "y" : 434
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 802,
          "y" : 434
        }
      }
    } ]
  }, {
    "id" : 63147,
    "reactomeId" : 11111462,
    "displayName" : "Homologues of PRKACA",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 661,
      "y" : 451
    },
    "minX" : 597,
    "maxX" : 767,
    "minY" : 426,
    "maxY" : 462,
    "prop" : {
      "x" : 597,
      "y" : 440,
      "width" : 128,
      "height" : 22
    },
    "textPosition" : {
      "x" : 608,
      "y" : 434
    },
    "connectors" : [ {
      "edgeId" : 63146,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 719,
          "y" : 434
        },
        "to" : {
          "x" : 767,
          "y" : 431
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 737,
            "y" : 426
          },
          "b" : {
            "x" : 749,
            "y" : 438
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 743,
            "y" : 432
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 726,
          "y" : 430
        },
        "b" : {
          "x" : 719,
          "y" : 434
        },
        "c" : {
          "x" : 726,
          "y" : 438
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 726,
          "y" : 438
        }
      }
    } ]
  }, {
    "id" : 63148,
    "reactomeId" : 11111468,
    "displayName" : "cAMP:PKA regulatory subunit",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 731,
      "y" : 384
    },
    "minX" : 665,
    "maxX" : 804,
    "minY" : 360,
    "maxY" : 431,
    "prop" : {
      "x" : 665,
      "y" : 366,
      "width" : 133,
      "height" : 36
    },
    "textPosition" : {
      "x" : 670,
      "y" : 367
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 798,
          "y" : 366
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 798,
          "y" : 366
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 63146,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 744,
          "y" : 405
        },
        "to" : {
          "x" : 767,
          "y" : 431
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 752,
          "y" : 408
        },
        "b" : {
          "x" : 744,
          "y" : 405
        },
        "c" : {
          "x" : 746,
          "y" : 413
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 746,
          "y" : 413
        }
      }
    } ]
  }, {
    "id" : 63164,
    "reactomeId" : 11119139,
    "displayName" : "p21 RAS:GTP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1993,
      "y" : 534
    },
    "minX" : 1950,
    "maxX" : 2043,
    "minY" : 517,
    "maxY" : 545,
    "prop" : {
      "x" : 1950,
      "y" : 523,
      "width" : 87,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1961,
      "y" : 510
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2037,
          "y" : 523
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2037,
          "y" : 523
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 63196,
    "reactomeId" : 11129010,
    "displayName" : "RAF/MAP kinase cascade",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1993,
      "y" : 648
    },
    "minX" : 1936,
    "maxX" : 2051,
    "minY" : 626,
    "maxY" : 670,
    "prop" : {
      "x" : 1936,
      "y" : 626,
      "width" : 115,
      "height" : 44
    },
    "textPosition" : {
      "x" : 1935,
      "y" : 626
    },
    "connectors" : [ ]
  } ],
  "edges" : [ {
    "id" : 63142,
    "reactomeId" : 11125371,
    "displayName" : "cAMP binds PKA tetramer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 888,
      "y" : 406
    },
    "minX" : 873,
    "maxX" : 894,
    "minY" : 381,
    "maxY" : 430,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 877,
        "y" : 381
      },
      "to" : {
        "x" : 888,
        "y" : 406
      }
    }, {
      "from" : {
        "x" : 888,
        "y" : 406
      },
      "to" : {
        "x" : 873,
        "y" : 430
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 873,
        "y" : 422
      },
      "b" : {
        "x" : 873,
        "y" : 430
      },
      "c" : {
        "x" : 880,
        "y" : 426
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 880,
        "y" : 426
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 888,
        "y" : 406
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 888,
        "y" : 406
      }
    },
    "inputs" : [ {
      "id" : 63143,
      "points" : [ {
        "x" : 901,
        "y" : 379
      } ]
    }, {
      "id" : 63144,
      "points" : [ {
        "x" : 849,
        "y" : 363
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 63145
    } ]
  }, {
    "id" : 63146,
    "reactomeId" : 11111471,
    "displayName" : "cAMP induces dissociation of inactive PKA tetramers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 790,
      "y" : 431
    },
    "minX" : 767,
    "maxX" : 816,
    "minY" : 425,
    "maxY" : 437,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 816,
        "y" : 433
      },
      "to" : {
        "x" : 790,
        "y" : 431
      }
    }, {
      "from" : {
        "x" : 790,
        "y" : 431
      },
      "to" : {
        "x" : 767,
        "y" : 431
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 784,
        "y" : 425
      },
      "b" : {
        "x" : 796,
        "y" : 437
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 790,
        "y" : 431
      }
    },
    "inputs" : [ {
      "id" : 63145
    } ],
    "outputs" : [ {
      "id" : 63147,
      "points" : [ {
        "x" : 719,
        "y" : 434
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 63148,
      "points" : [ {
        "x" : 744,
        "y" : 405
      } ]
    } ],
    "catalysts" : [ {
      "id" : 63145,
      "points" : [ {
        "x" : 816,
        "y" : 438
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 63156,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 728,
      "y" : 843
    },
    "minX" : 295,
    "maxX" : 1162,
    "minY" : 485,
    "maxY" : 1202,
    "prop" : {
      "x" : 295,
      "y" : 485,
      "width" : 867,
      "height" : 717
    },
    "textPosition" : {
      "x" : 307,
      "y" : 1151
    },
    "insets" : {
      "x" : 305,
      "y" : 495,
      "width" : 847,
      "height" : 697
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 63165, 63209 ]
  }, {
    "id" : 63149,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1161,
      "y" : 760
    },
    "minX" : 0,
    "maxX" : 2323,
    "minY" : 0,
    "maxY" : 1521,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 2323,
      "height" : 1521
    },
    "textPosition" : {
      "x" : 78,
      "y" : 1452
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 2303,
      "height" : 1501
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 63156, 63144, 63207, 63208, 63164, 63143, 63145, 63142, 63146, 63147, 63148, 63196, 63210, 63211 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 63210,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1993,
      "y" : 585
    },
    "minX" : 1987,
    "maxX" : 1999,
    "minY" : 548,
    "maxY" : 623,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1993,
        "y" : 548
      },
      "to" : {
        "x" : 1993,
        "y" : 623
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1989,
        "y" : 616
      },
      "b" : {
        "x" : 1993,
        "y" : 623
      },
      "c" : {
        "x" : 1997,
        "y" : 616
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1997,
        "y" : 616
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1987,
        "y" : 579
      },
      "b" : {
        "x" : 1999,
        "y" : 591
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1993,
        "y" : 585
      }
    },
    "inputs" : [ {
      "id" : 63164
    } ],
    "outputs" : [ {
      "id" : 63196
    } ]
  } ],
  "shadows" : [ {
    "id" : 63211,
    "reactomeId" : 11128332,
    "displayName" : "Post NMDA receptor activation events",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 793,
      "y" : 399
    },
    "minX" : 587,
    "maxX" : 1000,
    "minY" : 320,
    "maxY" : 479,
    "prop" : {
      "x" : 587,
      "y" : 320,
      "width" : 413,
      "height" : 159
    },
    "points" : [ {
      "x" : 587,
      "y" : 320
    }, {
      "x" : 1000,
      "y" : 320
    }, {
      "x" : 1000,
      "y" : 479
    }, {
      "x" : 587,
      "y" : 479
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 2323,
  "minY" : 0,
  "maxY" : 1521,
  "disease" : false
}