{
  "dbId" : 11107294,
  "stableId" : "R-SCE-202403",
  "displayName" : "TCR signaling",
  "nodes" : [ {
    "id" : 52928,
    "reactomeId" : 179856,
    "displayName" : "PI(4,5)P2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2093,
      "y" : 1726
    },
    "minX" : 2058,
    "maxX" : 2141,
    "minY" : 1657,
    "maxY" : 1764,
    "prop" : {
      "x" : 2058,
      "y" : 1711,
      "width" : 70,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2060,
      "y" : 1715
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2123,
          "y" : 1716
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2123,
          "y" : 1716
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52931,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2103,
          "y" : 1708
        },
        "to" : {
          "x" : 2141,
          "y" : 1657
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52927,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2100,
          "y" : 1744
        },
        "to" : {
          "x" : 2113,
          "y" : 1764
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52929,
    "reactomeId" : 11086750,
    "displayName" : "phospho-p-Y771,Y783,Y1254-PLCG1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1951,
      "y" : 1733
    },
    "minX" : 1896,
    "maxX" : 2113,
    "minY" : 1702,
    "maxY" : 1764,
    "prop" : {
      "x" : 1896,
      "y" : 1708,
      "width" : 111,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1906,
      "y" : 1709
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2007,
          "y" : 1708
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2007,
          "y" : 1708
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52927,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2010,
          "y" : 1743
        },
        "to" : {
          "x" : 2113,
          "y" : 1764
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52930,
    "reactomeId" : 11086755,
    "displayName" : "Activated PLC gamma1 bound to PIP2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2257,
      "y" : 1732
    },
    "minX" : 2197,
    "maxX" : 2323,
    "minY" : 1701,
    "maxY" : 1757,
    "prop" : {
      "x" : 2197,
      "y" : 1707,
      "width" : 120,
      "height" : 50
    },
    "textPosition" : {
      "x" : 2202,
      "y" : 1708
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2317,
          "y" : 1707
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2317,
          "y" : 1707
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52927,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52932,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2110,
      "y" : 1637
    },
    "minX" : 2089,
    "maxX" : 2141,
    "minY" : 1621,
    "maxY" : 1657,
    "prop" : {
      "x" : 2089,
      "y" : 1622,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2093,
      "y" : 1626
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2127,
          "y" : 1627
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2127,
          "y" : 1627
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52931,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2135,
          "y" : 1650
        },
        "to" : {
          "x" : 2141,
          "y" : 1657
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 52933,
    "reactomeId" : 112275,
    "displayName" : "DAGs",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2445,
      "y" : 1724
    },
    "minX" : 2355,
    "maxX" : 2471,
    "minY" : 1658,
    "maxY" : 1739,
    "prop" : {
      "x" : 2421,
      "y" : 1709,
      "width" : 49,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2425,
      "y" : 1713
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2465,
          "y" : 1714
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2465,
          "y" : 1714
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52931,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2424,
          "y" : 1706
        },
        "to" : {
          "x" : 2355,
          "y" : 1658
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2416,
          "y" : 1705
        },
        "b" : {
          "x" : 2424,
          "y" : 1706
        },
        "c" : {
          "x" : 2421,
          "y" : 1699
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2421,
          "y" : 1699
        }
      }
    } ]
  }, {
    "id" : 52934,
    "reactomeId" : 114520,
    "displayName" : "I(1,4,5)P3",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2425,
      "y" : 1598
    },
    "minX" : 2355,
    "maxX" : 2464,
    "minY" : 1582,
    "maxY" : 1658,
    "prop" : {
      "x" : 2388,
      "y" : 1583,
      "width" : 75,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2391,
      "y" : 1587
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2458,
          "y" : 1588
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2458,
          "y" : 1588
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52931,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2407,
          "y" : 1616
        },
        "to" : {
          "x" : 2355,
          "y" : 1658
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2404,
          "y" : 1623
        },
        "b" : {
          "x" : 2407,
          "y" : 1616
        },
        "c" : {
          "x" : 2399,
          "y" : 1617
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2399,
          "y" : 1617
        }
      }
    } ]
  }, {
    "id" : 52935,
    "reactomeId" : 11086764,
    "displayName" : "p-PLCG",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2375,
      "y" : 1730
    },
    "minX" : 2309,
    "maxX" : 2402,
    "minY" : 1662,
    "maxY" : 1741,
    "prop" : {
      "x" : 2349,
      "y" : 1719,
      "width" : 53,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2350,
      "y" : 1719
    },
    "connectors" : [ {
      "edgeId" : 52931,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2364,
          "y" : 1713
        },
        "to" : {
          "x" : 2316,
          "y" : 1669
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2313,
          "y" : 1666
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2313,
          "y" : 1666
        }
      }
    } ]
  }, {
    "id" : 53000,
    "reactomeId" : 11107250,
    "displayName" : "PIP3 activates AKT signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 2930,
      "y" : 1399
    },
    "minX" : 2862,
    "maxX" : 2999,
    "minY" : 1371,
    "maxY" : 1427,
    "prop" : {
      "x" : 2862,
      "y" : 1371,
      "width" : 137,
      "height" : 56
    },
    "textPosition" : {
      "x" : 2863,
      "y" : 1377
    },
    "connectors" : [ ]
  }, {
    "id" : 52937,
    "reactomeId" : 202277,
    "displayName" : "PIP3, PI(3,4)P2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3163,
      "y" : 1051
    },
    "minX" : 3113,
    "maxX" : 3214,
    "minY" : 1018,
    "maxY" : 1062,
    "prop" : {
      "x" : 3113,
      "y" : 1040,
      "width" : 101,
      "height" : 22
    },
    "textPosition" : {
      "x" : 3113,
      "y" : 1040
    },
    "connectors" : [ {
      "edgeId" : 52936,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3152,
          "y" : 1034
        },
        "to" : {
          "x" : 3131,
          "y" : 1018
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52938,
    "reactomeId" : 11086718,
    "displayName" : "PDPK1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3059,
      "y" : 1051
    },
    "minX" : 3035,
    "maxX" : 3131,
    "minY" : 1018,
    "maxY" : 1062,
    "prop" : {
      "x" : 3035,
      "y" : 1040,
      "width" : 48,
      "height" : 22
    },
    "textPosition" : {
      "x" : 3035,
      "y" : 1040
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3083,
          "y" : 1040
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3083,
          "y" : 1040
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52936,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3083,
          "y" : 1037
        },
        "to" : {
          "x" : 3131,
          "y" : 1018
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52939,
    "reactomeId" : 11086720,
    "displayName" : "PDK1:PIP2,PIP3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3164,
      "y" : 866
    },
    "minX" : 3113,
    "maxX" : 3242,
    "minY" : 460,
    "maxY" : 877,
    "prop" : {
      "x" : 3113,
      "y" : 855,
      "width" : 103,
      "height" : 22
    },
    "textPosition" : {
      "x" : 3113,
      "y" : 856
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3216,
          "y" : 855
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3216,
          "y" : 855
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52944,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3180,
          "y" : 852
        },
        "to" : {
          "x" : 3242,
          "y" : 815
        }
      }, {
        "from" : {
          "x" : 3242,
          "y" : 815
        },
        "to" : {
          "x" : 3239,
          "y" : 461
        }
      }, {
        "from" : {
          "x" : 3239,
          "y" : 461
        },
        "to" : {
          "x" : 3153,
          "y" : 464
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3149,
          "y" : 464
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3149,
          "y" : 464
        }
      }
    }, {
      "edgeId" : 52936,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52941,
    "reactomeId" : 11086632,
    "displayName" : "PRKCQ",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3048,
      "y" : 807
    },
    "minX" : 3001,
    "maxX" : 3143,
    "minY" : 778,
    "maxY" : 825,
    "prop" : {
      "x" : 3001,
      "y" : 789,
      "width" : 94,
      "height" : 36
    },
    "textPosition" : {
      "x" : 3024,
      "y" : 796
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3095,
          "y" : 789
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3095,
          "y" : 789
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52940,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3098,
          "y" : 792
        },
        "to" : {
          "x" : 3143,
          "y" : 778
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52973,
    "reactomeId" : 202247,
    "displayName" : "PI(3,4)P2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3163,
      "y" : 1188
    },
    "minX" : 3128,
    "maxX" : 3199,
    "minY" : 1172,
    "maxY" : 1203,
    "prop" : {
      "x" : 3128,
      "y" : 1173,
      "width" : 70,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3130,
      "y" : 1177
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3193,
          "y" : 1178
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3193,
          "y" : 1178
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 52942,
    "reactomeId" : 112275,
    "displayName" : "DAGs",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3165,
      "y" : 814
    },
    "minX" : 3141,
    "maxX" : 3191,
    "minY" : 778,
    "maxY" : 829,
    "prop" : {
      "x" : 3141,
      "y" : 799,
      "width" : 49,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3145,
      "y" : 803
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3185,
          "y" : 804
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3185,
          "y" : 804
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52940,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3155,
          "y" : 796
        },
        "to" : {
          "x" : 3143,
          "y" : 778
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52943,
    "reactomeId" : 11086743,
    "displayName" : "PKC-theta (open): DAG",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3153,
      "y" : 698
    },
    "minX" : 3095,
    "maxX" : 3218,
    "minY" : 674,
    "maxY" : 716,
    "prop" : {
      "x" : 3095,
      "y" : 680,
      "width" : 117,
      "height" : 36
    },
    "textPosition" : {
      "x" : 3111,
      "y" : 681
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3212,
          "y" : 680
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3212,
          "y" : 680
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52940,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52945,
    "reactomeId" : 11086729,
    "displayName" : "p-Y90-PKC-theta:DAG",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3161,
      "y" : 537
    },
    "minX" : 3103,
    "maxX" : 3226,
    "minY" : 488,
    "maxY" : 555,
    "prop" : {
      "x" : 3103,
      "y" : 519,
      "width" : 117,
      "height" : 36
    },
    "textPosition" : {
      "x" : 3105,
      "y" : 520
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3220,
          "y" : 519
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3220,
          "y" : 519
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52944,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3152,
          "y" : 516
        },
        "to" : {
          "x" : 3137,
          "y" : 488
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52946,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3064,
      "y" : 514
    },
    "minX" : 3044,
    "maxX" : 3137,
    "minY" : 488,
    "maxY" : 529,
    "prop" : {
      "x" : 3044,
      "y" : 499,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3048,
      "y" : 503
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3079,
          "y" : 504
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3079,
          "y" : 504
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52944,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3087,
          "y" : 506
        },
        "to" : {
          "x" : 3137,
          "y" : 488
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 3106,
            "y" : 491
          },
          "b" : {
            "x" : 3118,
            "y" : 503
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3112,
            "y" : 497
          }
        }
      }
    } ]
  }, {
    "id" : 52947,
    "reactomeId" : 11086736,
    "displayName" : "Active PKC theta bound to DAG",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3163,
      "y" : 394
    },
    "minX" : 3106,
    "maxX" : 3227,
    "minY" : 370,
    "maxY" : 436,
    "prop" : {
      "x" : 3106,
      "y" : 376,
      "width" : 115,
      "height" : 36
    },
    "textPosition" : {
      "x" : 3106,
      "y" : 377
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3221,
          "y" : 376
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3221,
          "y" : 376
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52944,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3151,
          "y" : 415
        },
        "to" : {
          "x" : 3137,
          "y" : 436
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3150,
          "y" : 423
        },
        "b" : {
          "x" : 3151,
          "y" : 415
        },
        "c" : {
          "x" : 3144,
          "y" : 419
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3144,
          "y" : 419
        }
      }
    } ]
  }, {
    "id" : 52948,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3063,
      "y" : 404
    },
    "minX" : 3043,
    "maxX" : 3137,
    "minY" : 388,
    "maxY" : 436,
    "prop" : {
      "x" : 3043,
      "y" : 389,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3047,
      "y" : 393
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3079,
          "y" : 394
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3079,
          "y" : 394
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52944,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3087,
          "y" : 412
        },
        "to" : {
          "x" : 3137,
          "y" : 436
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 3106,
            "y" : 418
          },
          "b" : {
            "x" : 3118,
            "y" : 430
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3112,
            "y" : 424
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 3095,
          "y" : 411
        },
        "b" : {
          "x" : 3087,
          "y" : 412
        },
        "c" : {
          "x" : 3092,
          "y" : 419
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3092,
          "y" : 419
        }
      }
    } ]
  }, {
    "id" : 52950,
    "reactomeId" : 179838,
    "displayName" : "PI(3,4,5)P3",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3164,
      "y" : 1375
    },
    "minX" : 3071,
    "maxX" : 3206,
    "minY" : 1359,
    "maxY" : 1390,
    "prop" : {
      "x" : 3123,
      "y" : 1360,
      "width" : 82,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3125,
      "y" : 1364
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3200,
          "y" : 1365
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3200,
          "y" : 1365
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52949,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3120,
          "y" : 1368
        },
        "to" : {
          "x" : 3071,
          "y" : 1360
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52951,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3114,
      "y" : 1344
    },
    "minX" : 3071,
    "maxX" : 3134,
    "minY" : 1329,
    "maxY" : 1360,
    "prop" : {
      "x" : 3096,
      "y" : 1330,
      "width" : 37,
      "height" : 28
    },
    "textPosition" : {
      "x" : 3097,
      "y" : 1333
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3128,
          "y" : 1335
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3128,
          "y" : 1335
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52949,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3093,
          "y" : 1350
        },
        "to" : {
          "x" : 3071,
          "y" : 1360
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 52952,
    "reactomeId" : 179856,
    "displayName" : "PI(4,5)P2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3163,
      "y" : 1135
    },
    "minX" : 3057,
    "maxX" : 3199,
    "minY" : 1119,
    "maxY" : 1163,
    "prop" : {
      "x" : 3128,
      "y" : 1120,
      "width" : 70,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3130,
      "y" : 1124
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3193,
          "y" : 1125
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3193,
          "y" : 1125
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52949,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3125,
          "y" : 1144
        },
        "to" : {
          "x" : 3057,
          "y" : 1163
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3119,
          "y" : 1150
        },
        "b" : {
          "x" : 3125,
          "y" : 1144
        },
        "c" : {
          "x" : 3117,
          "y" : 1142
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3117,
          "y" : 1142
        }
      }
    } ]
  }, {
    "id" : 52953,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3100,
      "y" : 1197
    },
    "minX" : 3057,
    "maxX" : 3115,
    "minY" : 1163,
    "maxY" : 1212,
    "prop" : {
      "x" : 3087,
      "y" : 1182,
      "width" : 27,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3091,
      "y" : 1186
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3109,
          "y" : 1187
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3109,
          "y" : 1187
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52949,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3084,
          "y" : 1186
        },
        "to" : {
          "x" : 3057,
          "y" : 1163
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3076,
          "y" : 1185
        },
        "b" : {
          "x" : 3084,
          "y" : 1186
        },
        "c" : {
          "x" : 3081,
          "y" : 1178
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3081,
          "y" : 1178
        }
      }
    } ]
  }, {
    "id" : 52954,
    "reactomeId" : 11086351,
    "displayName" : "TEP1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2944,
      "y" : 1289
    },
    "minX" : 2924,
    "maxX" : 3015,
    "minY" : 1272,
    "maxY" : 1300,
    "prop" : {
      "x" : 2924,
      "y" : 1278,
      "width" : 40,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2924,
      "y" : 1278
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2964,
          "y" : 1278
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2964,
          "y" : 1278
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52949,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2967,
          "y" : 1290
        },
        "to" : {
          "x" : 3007,
          "y" : 1292
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3011,
          "y" : 1292
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3011,
          "y" : 1292
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 52944,
    "reactomeId" : 11086739,
    "displayName" : "Phosphorylation of PKC theta",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3137,
      "y" : 464
    },
    "minX" : 3131,
    "maxX" : 3143,
    "minY" : 436,
    "maxY" : 488,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3137,
        "y" : 488
      },
      "to" : {
        "x" : 3137,
        "y" : 464
      }
    }, {
      "from" : {
        "x" : 3137,
        "y" : 464
      },
      "to" : {
        "x" : 3137,
        "y" : 436
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3131,
        "y" : 458
      },
      "b" : {
        "x" : 3143,
        "y" : 470
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3137,
        "y" : 464
      }
    },
    "inputs" : [ {
      "id" : 52945,
      "points" : [ {
        "x" : 3152,
        "y" : 516
      } ]
    }, {
      "id" : 52946,
      "points" : [ {
        "x" : 3087,
        "y" : 506
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 52947,
      "points" : [ {
        "x" : 3151,
        "y" : 415
      } ]
    }, {
      "id" : 52948,
      "points" : [ {
        "x" : 3087,
        "y" : 412
      } ],
      "stoichiometry" : 3
    } ],
    "catalysts" : [ {
      "id" : 52939,
      "points" : [ {
        "x" : 3180,
        "y" : 852
      }, {
        "x" : 3242,
        "y" : 815
      }, {
        "x" : 3239,
        "y" : 461
      } ]
    } ]
  }, {
    "id" : 52931,
    "reactomeId" : 11086767,
    "displayName" : "PLC-gamma1 hydrolyses PIP2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2304,
      "y" : 1658
    },
    "minX" : 2141,
    "maxX" : 2355,
    "minY" : 1652,
    "maxY" : 1664,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2141,
        "y" : 1657
      },
      "to" : {
        "x" : 2304,
        "y" : 1658
      }
    }, {
      "from" : {
        "x" : 2304,
        "y" : 1658
      },
      "to" : {
        "x" : 2355,
        "y" : 1658
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2298,
        "y" : 1652
      },
      "b" : {
        "x" : 2310,
        "y" : 1664
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2304,
        "y" : 1658
      }
    },
    "inputs" : [ {
      "id" : 52928,
      "points" : [ {
        "x" : 2103,
        "y" : 1708
      } ]
    }, {
      "id" : 52932,
      "points" : [ {
        "x" : 2135,
        "y" : 1650
      } ]
    } ],
    "outputs" : [ {
      "id" : 52933,
      "points" : [ {
        "x" : 2424,
        "y" : 1706
      } ]
    }, {
      "id" : 52934,
      "points" : [ {
        "x" : 2407,
        "y" : 1616
      } ]
    } ],
    "catalysts" : [ {
      "id" : 52935,
      "points" : [ {
        "x" : 2364,
        "y" : 1713
      } ]
    } ]
  }, {
    "id" : 52949,
    "reactomeId" : 11086354,
    "displayName" : "PTEN dephosphorylates PIP3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3023,
      "y" : 1293
    },
    "minX" : 3017,
    "maxX" : 3071,
    "minY" : 1163,
    "maxY" : 1360,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3071,
        "y" : 1360
      },
      "to" : {
        "x" : 3023,
        "y" : 1293
      }
    }, {
      "from" : {
        "x" : 3023,
        "y" : 1293
      },
      "to" : {
        "x" : 3057,
        "y" : 1163
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3017,
        "y" : 1287
      },
      "b" : {
        "x" : 3029,
        "y" : 1299
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3023,
        "y" : 1293
      }
    },
    "inputs" : [ {
      "id" : 52950,
      "points" : [ {
        "x" : 3120,
        "y" : 1368
      } ]
    }, {
      "id" : 52951,
      "points" : [ {
        "x" : 3093,
        "y" : 1350
      } ]
    } ],
    "outputs" : [ {
      "id" : 52952,
      "points" : [ {
        "x" : 3125,
        "y" : 1144
      } ]
    }, {
      "id" : 52953,
      "points" : [ {
        "x" : 3084,
        "y" : 1186
      } ]
    } ],
    "catalysts" : [ {
      "id" : 52954,
      "points" : [ {
        "x" : 2967,
        "y" : 1290
      } ]
    } ]
  }, {
    "id" : 52936,
    "reactomeId" : 11086722,
    "displayName" : "Translocation of PDK1 to Plasma membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3131,
      "y" : 996
    },
    "minX" : 3125,
    "maxX" : 3161,
    "minY" : 880,
    "maxY" : 1018,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3131,
        "y" : 1018
      },
      "to" : {
        "x" : 3131,
        "y" : 996
      }
    }, {
      "from" : {
        "x" : 3131,
        "y" : 996
      },
      "to" : {
        "x" : 3161,
        "y" : 880
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3163,
        "y" : 888
      },
      "b" : {
        "x" : 3161,
        "y" : 880
      },
      "c" : {
        "x" : 3155,
        "y" : 886
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3155,
        "y" : 886
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3131,
        "y" : 996
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3131,
        "y" : 996
      }
    },
    "inputs" : [ {
      "id" : 52937,
      "points" : [ {
        "x" : 3152,
        "y" : 1034
      } ]
    }, {
      "id" : 52938,
      "points" : [ {
        "x" : 3083,
        "y" : 1037
      } ]
    } ],
    "outputs" : [ {
      "id" : 52939
    } ]
  }, {
    "id" : 52940,
    "reactomeId" : 11086745,
    "displayName" : "Translocation of PKC theta to plasma membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3143,
      "y" : 751
    },
    "minX" : 3137,
    "maxX" : 3149,
    "minY" : 719,
    "maxY" : 778,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3143,
        "y" : 778
      },
      "to" : {
        "x" : 3143,
        "y" : 751
      }
    }, {
      "from" : {
        "x" : 3143,
        "y" : 751
      },
      "to" : {
        "x" : 3149,
        "y" : 719
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3152,
        "y" : 727
      },
      "b" : {
        "x" : 3149,
        "y" : 719
      },
      "c" : {
        "x" : 3144,
        "y" : 725
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3144,
        "y" : 725
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3143,
        "y" : 751
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3143,
        "y" : 751
      }
    },
    "inputs" : [ {
      "id" : 52941,
      "points" : [ {
        "x" : 3098,
        "y" : 792
      } ]
    }, {
      "id" : 52942,
      "points" : [ {
        "x" : 3155,
        "y" : 796
      } ]
    } ],
    "outputs" : [ {
      "id" : 52943
    } ]
  }, {
    "id" : 52927,
    "reactomeId" : 11086757,
    "displayName" : "Translocation of PLC-gamma1 to PIP2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2162,
      "y" : 1765
    },
    "minX" : 2113,
    "maxX" : 2194,
    "minY" : 1752,
    "maxY" : 1771,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2113,
        "y" : 1764
      },
      "to" : {
        "x" : 2162,
        "y" : 1765
      }
    }, {
      "from" : {
        "x" : 2162,
        "y" : 1765
      },
      "to" : {
        "x" : 2194,
        "y" : 1752
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2189,
        "y" : 1758
      },
      "b" : {
        "x" : 2194,
        "y" : 1752
      },
      "c" : {
        "x" : 2186,
        "y" : 1751
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2186,
        "y" : 1751
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2162,
        "y" : 1765
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2162,
        "y" : 1765
      }
    },
    "inputs" : [ {
      "id" : 52928,
      "points" : [ {
        "x" : 2100,
        "y" : 1744
      } ]
    }, {
      "id" : 52929,
      "points" : [ {
        "x" : 2010,
        "y" : 1743
      } ]
    } ],
    "outputs" : [ {
      "id" : 52930
    } ]
  } ],
  "compartments" : [ {
    "id" : 52996,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1021,
      "y" : 579
    },
    "minX" : 908,
    "maxX" : 1134,
    "minY" : 502,
    "maxY" : 657,
    "prop" : {
      "x" : 908,
      "y" : 502,
      "width" : 226,
      "height" : 155
    },
    "textPosition" : {
      "x" : 978,
      "y" : 588
    },
    "insets" : {
      "x" : 918,
      "y" : 512,
      "width" : 206,
      "height" : 135
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 52966,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1583,
      "y" : 867
    },
    "minX" : 0,
    "maxX" : 3166,
    "minY" : 0,
    "maxY" : 1734,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 3166,
      "height" : 1734
    },
    "textPosition" : {
      "x" : 525,
      "y" : 1358
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 3146,
      "height" : 1714
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 52929, 52928, 52930, 52931, 52932, 52933, 52950, 52973, 52936, 52937, 52938, 52939, 52940, 52941, 52943, 52952, 52942, 52945, 52944, 52946, 52947, 52948, 52934, 53001, 53003, 53007, 52996, 52954, 52949, 52953, 52951, 53000, 53009, 52935 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 53009,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 3061,
      "y" : 1385
    },
    "minX" : 3002,
    "maxX" : 3120,
    "minY" : 1379,
    "maxY" : 1391,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 3120,
        "y" : 1379
      },
      "to" : {
        "x" : 3002,
        "y" : 1391
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3008,
        "y" : 1386
      },
      "b" : {
        "x" : 3002,
        "y" : 1391
      },
      "c" : {
        "x" : 3009,
        "y" : 1394
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 3009,
        "y" : 1394
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3055,
        "y" : 1379
      },
      "b" : {
        "x" : 3067,
        "y" : 1391
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3061,
        "y" : 1385
      }
    },
    "inputs" : [ {
      "id" : 52950
    } ],
    "outputs" : [ {
      "id" : 53000
    } ]
  }, {
    "id" : 53005,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 3258,
      "y" : 1165
    },
    "minX" : 3170,
    "maxX" : 3264,
    "minY" : 1068,
    "maxY" : 1357,
    "segments" : [ {
      "from" : {
        "x" : 3170,
        "y" : 1357
      },
      "to" : {
        "x" : 3258,
        "y" : 1165
      }
    }, {
      "from" : {
        "x" : 3258,
        "y" : 1165
      },
      "to" : {
        "x" : 3172,
        "y" : 1068
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3252,
        "y" : 1159
      },
      "b" : {
        "x" : 3264,
        "y" : 1171
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3258,
        "y" : 1165
      }
    },
    "inputs" : [ {
      "id" : 52950
    } ],
    "outputs" : [ {
      "id" : 52937
    } ]
  }, {
    "id" : 53006,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 3234,
      "y" : 1160
    },
    "minX" : 3170,
    "maxX" : 3240,
    "minY" : 1068,
    "maxY" : 1174,
    "segments" : [ {
      "from" : {
        "x" : 3201,
        "y" : 1174
      },
      "to" : {
        "x" : 3234,
        "y" : 1160
      }
    }, {
      "from" : {
        "x" : 3234,
        "y" : 1160
      },
      "to" : {
        "x" : 3170,
        "y" : 1068
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3228,
        "y" : 1154
      },
      "b" : {
        "x" : 3240,
        "y" : 1166
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3234,
        "y" : 1160
      }
    },
    "inputs" : [ {
      "id" : 52973
    } ],
    "outputs" : [ {
      "id" : 52937
    } ]
  } ],
  "shadows" : [ {
    "id" : 53010,
    "reactomeId" : 11107292,
    "displayName" : "Downstream TCR signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 3072,
      "y" : 883
    },
    "minX" : 2914,
    "maxX" : 3231,
    "minY" : 366,
    "maxY" : 1400,
    "prop" : {
      "x" : 2914,
      "y" : 366,
      "width" : 317,
      "height" : 1034
    },
    "points" : [ {
      "x" : 2914,
      "y" : 366
    }, {
      "x" : 3231,
      "y" : 366
    }, {
      "x" : 3231,
      "y" : 1400
    }, {
      "x" : 2914,
      "y" : 1400
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 53011,
    "reactomeId" : 11107320,
    "displayName" : "Generation of second messenger molecules",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 2183,
      "y" : 1677
    },
    "minX" : 1886,
    "maxX" : 2480,
    "minY" : 1573,
    "maxY" : 1781,
    "prop" : {
      "x" : 1886,
      "y" : 1573,
      "width" : 594,
      "height" : 208
    },
    "points" : [ {
      "x" : 1886,
      "y" : 1573
    }, {
      "x" : 2480,
      "y" : 1573
    }, {
      "x" : 2480,
      "y" : 1781
    }, {
      "x" : 1886,
      "y" : 1781
    } ],
    "colour" : "#dc3912"
  } ],
  "minX" : 0,
  "maxX" : 3264,
  "minY" : 0,
  "maxY" : 1771,
  "disease" : false
}