{ "dbId" : 11106982, "stableId" : "R-SCE-418555", "displayName" : "G alpha (s) signalling events", "nodes" : [ { "id" : 24529, "reactomeId" : 11104475, "displayName" : "PDE3A", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 733, "y" : 580 }, "minX" : 683, "maxX" : 805, "minY" : 515, "maxY" : 591, "prop" : { "x" : 709, "y" : 569, "width" : 48, "height" : 22 }, "textPosition" : { "x" : 712, "y" : 563 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 757, "y" : 569 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 757, "y" : 569 } } }, "connectors" : [ { "edgeId" : 24528, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 706, "y" : 580 }, "to" : { "x" : 691, "y" : 580 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 687, "y" : 580 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 687, "y" : 580 } } }, { "edgeId" : 24530, "type" : "INPUT", "segments" : [ { "from" : { "x" : 745, "y" : 566 }, "to" : { "x" : 805, "y" : 515 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 24546, "reactomeId" : 11106980, "displayName" : "GPER1 signaling", "schemaClass" : "Pathway", "renderableClass" : "ProcessNode", "position" : { "x" : 1631, "y" : 208 }, "minX" : 1545, "maxX" : 1717, "minY" : 156, "maxY" : 260, "prop" : { "x" : 1545, "y" : 156, "width" : 172, "height" : 104 }, "textPosition" : { "x" : 1572, "y" : 193 }, "connectors" : [ ] }, { "id" : 24531, "reactomeId" : 9629673, "displayName" : "PDE3A inhibitors", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 887, "y" : 515 }, "minX" : 805, "maxX" : 936, "minY" : 504, "maxY" : 526, "prop" : { "x" : 839, "y" : 504, "width" : 97, "height" : 22 }, "textPosition" : { "x" : 854, "y" : 498 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 24530, "type" : "INPUT", "segments" : [ { "from" : { "x" : 833, "y" : 515 }, "to" : { "x" : 805, "y" : 515 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 24532, "reactomeId" : 11104480, "displayName" : "PDE3A inhibitors:PDE3A", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 756, "y" : 447 }, "minX" : 716, "maxX" : 803, "minY" : 418, "maxY" : 471, "prop" : { "x" : 716, "y" : 424, "width" : 81, "height" : 47 }, "textPosition" : { "x" : 721, "y" : 422 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 797, "y" : 424 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 797, "y" : 424 } } }, "connectors" : [ { "edgeId" : 24530, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 24534, "reactomeId" : 11105039, "displayName" : "PDE3B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 728, "y" : 615 }, "minX" : 657, "maxX" : 758, "minY" : 585, "maxY" : 626, "prop" : { "x" : 705, "y" : 604, "width" : 47, "height" : 22 }, "textPosition" : { "x" : 708, "y" : 598 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 752, "y" : 604 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 752, "y" : 604 } } }, "connectors" : [ { "edgeId" : 24533, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 702, "y" : 605 }, "to" : { "x" : 665, "y" : 591 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 661, "y" : 589 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 661, "y" : 589 } } } ] }, { "id" : 24524, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 609, "y" : 531 }, "minX" : 537, "maxX" : 675, "minY" : 515, "maxY" : 546, "prop" : { "x" : 588, "y" : 516, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 592, "y" : 520 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 626, "y" : 521 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 626, "y" : 521 } } }, "connectors" : [ { "edgeId" : 24528, "type" : "INPUT", "segments" : [ { "from" : { "x" : 634, "y" : 530 }, "to" : { "x" : 675, "y" : 529 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 24533, "type" : "INPUT", "segments" : [ { "from" : { "x" : 634, "y" : 538 }, "to" : { "x" : 650, "y" : 545 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 24523, "type" : "INPUT", "segments" : [ { "from" : { "x" : 585, "y" : 531 }, "to" : { "x" : 537, "y" : 531 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 24525, "reactomeId" : 30389, "displayName" : "cAMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 616, "y" : 477 }, "minX" : 537, "maxX" : 675, "minY" : 461, "maxY" : 545, "prop" : { "x" : 592, "y" : 462, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 595, "y" : 466 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 635, "y" : 467 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 635, "y" : 467 } } }, "connectors" : [ { "edgeId" : 24528, "type" : "INPUT", "segments" : [ { "from" : { "x" : 633, "y" : 495 }, "to" : { "x" : 675, "y" : 529 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 24533, "type" : "INPUT", "segments" : [ { "from" : { "x" : 623, "y" : 495 }, "to" : { "x" : 650, "y" : 545 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 24523, "type" : "INPUT", "segments" : [ { "from" : { "x" : 594, "y" : 495 }, "to" : { "x" : 537, "y" : 531 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 24526, "reactomeId" : 76577, "displayName" : "AMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 625, "y" : 659 }, "minX" : 604, "maxX" : 647, "minY" : 643, "maxY" : 674, "prop" : { "x" : 604, "y" : 644, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 608, "y" : 648 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 641, "y" : 649 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 641, "y" : 649 } } }, "connectors" : [ { "edgeId" : 24528, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 24533, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 24523, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 24543, "reactomeId" : 11107326, "displayName" : "G-protein beta:gamma signalling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 320, "y" : 131 }, "minX" : 256, "maxX" : 384, "minY" : 106, "maxY" : 156, "prop" : { "x" : 256, "y" : 106, "width" : 128, "height" : 50 }, "textPosition" : { "x" : 257, "y" : 109 }, "connectors" : [ ] }, { "id" : 24527, "reactomeId" : 11088227, "displayName" : "Phosphodiesterases, cyclic AMP-selective", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 462, "y" : 568 }, "minX" : 426, "maxX" : 529, "minY" : 557, "maxY" : 579, "prop" : { "x" : 426, "y" : 557, "width" : 73, "height" : 22 }, "textPosition" : { "x" : 427, "y" : 530 }, "connectors" : [ { "edgeId" : 24523, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 505, "y" : 567 }, "to" : { "x" : 521, "y" : 567 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 525, "y" : 567 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 525, "y" : 567 } } } ] } ], "edges" : [ { "id" : 24528, "reactomeId" : 11104478, "displayName" : "PDE3A hydrolyses cAMP to AMP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 675, "y" : 580 }, "minX" : 634, "maxX" : 681, "minY" : 529, "maxY" : 641, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 675, "y" : 529 }, "to" : { "x" : 675, "y" : 580 } }, { "from" : { "x" : 675, "y" : 580 }, "to" : { "x" : 634, "y" : 641 } } ], "endShape" : { "a" : { "x" : 635, "y" : 633 }, "b" : { "x" : 634, "y" : 641 }, "c" : { "x" : 641, "y" : 637 }, "type" : "ARROW", "centre" : { "x" : 641, "y" : 637 } }, "reactionShape" : { "a" : { "x" : 669, "y" : 574 }, "b" : { "x" : 681, "y" : 586 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 675, "y" : 580 } }, "inputs" : [ { "id" : 24525, "points" : [ { "x" : 633, "y" : 495 } ] }, { "id" : 24524, "points" : [ { "x" : 634, "y" : 530 } ] } ], "outputs" : [ { "id" : 24526 } ], "catalysts" : [ { "id" : 24529, "points" : [ { "x" : 706, "y" : 580 } ] } ] }, { "id" : 24530, "reactomeId" : 11104482, "displayName" : "PDE3A inhibitors bind PDE3A", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 806, "y" : 513 }, "minX" : 773, "maxX" : 812, "minY" : 474, "maxY" : 519, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 805, "y" : 515 }, "to" : { "x" : 806, "y" : 513 } }, { "from" : { "x" : 806, "y" : 513 }, "to" : { "x" : 773, "y" : 474 } } ], "endShape" : { "a" : { "x" : 781, "y" : 477 }, "b" : { "x" : 773, "y" : 474 }, "c" : { "x" : 774, "y" : 482 }, "type" : "ARROW", "centre" : { "x" : 774, "y" : 482 } }, "reactionShape" : { "c" : { "x" : 806, "y" : 513 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 806, "y" : 513 } }, "inputs" : [ { "id" : 24529, "points" : [ { "x" : 745, "y" : 566 } ] }, { "id" : 24531, "points" : [ { "x" : 833, "y" : 515 } ] } ], "outputs" : [ { "id" : 24532 } ] }, { "id" : 24533, "reactomeId" : 11105042, "displayName" : "PDE3B hydrolyses cAMP to AMP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 650, "y" : 585 }, "minX" : 630, "maxX" : 656, "minY" : 545, "maxY" : 641, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 650, "y" : 545 }, "to" : { "x" : 650, "y" : 585 } }, { "from" : { "x" : 650, "y" : 585 }, "to" : { "x" : 630, "y" : 641 } } ], "endShape" : { "a" : { "x" : 629, "y" : 633 }, "b" : { "x" : 630, "y" : 641 }, "c" : { "x" : 636, "y" : 636 }, "type" : "ARROW", "centre" : { "x" : 636, "y" : 636 } }, "reactionShape" : { "a" : { "x" : 644, "y" : 579 }, "b" : { "x" : 656, "y" : 591 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 650, "y" : 585 } }, "inputs" : [ { "id" : 24525, "points" : [ { "x" : 623, "y" : 495 } ] }, { "id" : 24524, "points" : [ { "x" : 634, "y" : 538 } ] } ], "outputs" : [ { "id" : 24526 } ], "catalysts" : [ { "id" : 24534, "points" : [ { "x" : 702, "y" : 605 } ] } ] }, { "id" : 24523, "reactomeId" : 11088230, "displayName" : "cAMP degradation by Phosphodiesterases", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 537, "y" : 567 }, "minX" : 531, "maxX" : 606, "minY" : 531, "maxY" : 641, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 537, "y" : 531 }, "to" : { "x" : 537, "y" : 567 } }, { "from" : { "x" : 537, "y" : 567 }, "to" : { "x" : 537, "y" : 588 } }, { "from" : { "x" : 537, "y" : 588 }, "to" : { "x" : 606, "y" : 641 } } ], "endShape" : { "a" : { "x" : 598, "y" : 640 }, "b" : { "x" : 606, "y" : 641 }, "c" : { "x" : 603, "y" : 634 }, "type" : "ARROW", "centre" : { "x" : 603, "y" : 634 } }, "reactionShape" : { "a" : { "x" : 531, "y" : 561 }, "b" : { "x" : 543, "y" : 573 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 537, "y" : 567 } }, "inputs" : [ { "id" : 24524, "points" : [ { "x" : 585, "y" : 531 } ] }, { "id" : 24525, "points" : [ { "x" : 594, "y" : 495 } ] } ], "outputs" : [ { "id" : 24526 } ], "catalysts" : [ { "id" : 24527, "points" : [ { "x" : 505, "y" : 567 } ] } ] } ], "compartments" : [ { "id" : 24535, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 828, "y" : 366 }, "minX" : 0, "maxX" : 1656, "minY" : 0, "maxY" : 732, "prop" : { "x" : 0, "y" : 0, "width" : 1656, "height" : 732 }, "textPosition" : { "x" : 121, "y" : 71 }, "insets" : { "x" : 10, "y" : 10, "width" : 1636, "height" : 712 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 24525, 24523, 24527, 24524, 24526, 24543, 24547, 24528, 24530, 24531, 24532, 24529, 24533, 24534, 24546 ] } ], "notes" : [ ], "links" : [ ], "shadows" : [ ], "minX" : 0, "maxX" : 1717, "minY" : 0, "maxY" : 732, "disease" : false }