{
  "dbId" : 11079253,
  "stableId" : "R-SPO-983705",
  "displayName" : "Signaling by the B Cell Receptor (BCR)",
  "nodes" : [ {
    "id" : 3522,
    "reactomeId" : 114519,
    "displayName" : "DAG",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1287,
      "y" : 1073
    },
    "minX" : 1241,
    "maxX" : 1493,
    "minY" : 1057,
    "maxY" : 1312,
    "prop" : {
      "x" : 1268,
      "y" : 1058,
      "width" : 38,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1270,
      "y" : 1062
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1301,
          "y" : 1063
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1301,
          "y" : 1063
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 3521,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1309,
          "y" : 1073
        },
        "to" : {
          "x" : 1493,
          "y" : 1083
        }
      }, {
        "from" : {
          "x" : 1493,
          "y" : 1083
        },
        "to" : {
          "x" : 1488,
          "y" : 1291
        }
      }, {
        "from" : {
          "x" : 1488,
          "y" : 1291
        },
        "to" : {
          "x" : 1241,
          "y" : 1312
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3523,
    "reactomeId" : 74016,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 775,
      "y" : 1041
    },
    "minX" : 753,
    "maxX" : 1241,
    "minY" : 1025,
    "maxY" : 1315,
    "prop" : {
      "x" : 753,
      "y" : 1026,
      "width" : 45,
      "height" : 30
    },
    "textPosition" : {
      "x" : 754,
      "y" : 1030
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 793,
          "y" : 1031
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 793,
          "y" : 1031
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 3521,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 788,
          "y" : 1059
        },
        "to" : {
          "x" : 1022,
          "y" : 1315
        }
      }, {
        "from" : {
          "x" : 1022,
          "y" : 1315
        },
        "to" : {
          "x" : 1241,
          "y" : 1312
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 899,
            "y" : 1181
          },
          "b" : {
            "x" : 911,
            "y" : 1193
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 905,
            "y" : 1187
          }
        }
      }
    } ]
  }, {
    "id" : 3524,
    "reactomeId" : 11056068,
    "displayName" : "Homologues of PRKCB",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1112,
      "y" : 1271
    },
    "minX" : 1090,
    "maxX" : 1241,
    "minY" : 1260,
    "maxY" : 1312,
    "prop" : {
      "x" : 1090,
      "y" : 1260,
      "width" : 44,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1090,
      "y" : 1233
    },
    "connectors" : [ {
      "edgeId" : 3521,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1137,
          "y" : 1277
        },
        "to" : {
          "x" : 1241,
          "y" : 1312
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3525,
    "reactomeId" : 33625,
    "displayName" : "PS",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1255,
      "y" : 1279
    },
    "minX" : 1240,
    "maxX" : 1272,
    "minY" : 1263,
    "maxY" : 1312,
    "prop" : {
      "x" : 1240,
      "y" : 1264,
      "width" : 31,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1243,
      "y" : 1268
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1266,
          "y" : 1269
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1266,
          "y" : 1269
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 3521,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1248,
          "y" : 1297
        },
        "to" : {
          "x" : 1241,
          "y" : 1312
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3526,
    "reactomeId" : 11056088,
    "displayName" : "Activated PKC beta",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1306,
      "y" : 1362
    },
    "minX" : 1242,
    "maxX" : 1377,
    "minY" : 1345,
    "maxY" : 1374,
    "prop" : {
      "x" : 1242,
      "y" : 1351,
      "width" : 129,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1243,
      "y" : 1353
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1371,
          "y" : 1351
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1371,
          "y" : 1351
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 3521,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3558,
    "reactomeId" : 179838,
    "displayName" : "PI(3,4,5)P3",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1243,
      "y" : 819
    },
    "minX" : 1205,
    "maxX" : 1283,
    "minY" : 803,
    "maxY" : 834,
    "prop" : {
      "x" : 1205,
      "y" : 804,
      "width" : 77,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1205,
      "y" : 808
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1277,
          "y" : 809
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1277,
          "y" : 809
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 3560,
    "reactomeId" : 11078911,
    "displayName" : "PIP3 activates AKT signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1437,
      "y" : 840
    },
    "minX" : 1337,
    "maxX" : 1538,
    "minY" : 817,
    "maxY" : 864,
    "prop" : {
      "x" : 1337,
      "y" : 817,
      "width" : 201,
      "height" : 47
    },
    "textPosition" : {
      "x" : 1342,
      "y" : 826
    },
    "connectors" : [ ]
  }, {
    "id" : 3528,
    "reactomeId" : 9678991,
    "displayName" : "tacrolimus",
    "schemaClass" : "ChemicalDrug",
    "renderableClass" : "ChemicalDrug",
    "position" : {
      "x" : 698,
      "y" : 1401
    },
    "minX" : 610,
    "maxX" : 742,
    "minY" : 1377,
    "maxY" : 1418,
    "prop" : {
      "x" : 654,
      "y" : 1385,
      "width" : 88,
      "height" : 33
    },
    "textPosition" : {
      "x" : 661,
      "y" : 1391
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 3527,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 651,
          "y" : 1389
        },
        "to" : {
          "x" : 610,
          "y" : 1377
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3529,
    "reactomeId" : 11075895,
    "displayName" : "fkh1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 667,
      "y" : 1334
    },
    "minX" : 610,
    "maxX" : 700,
    "minY" : 1316,
    "maxY" : 1377,
    "prop" : {
      "x" : 640,
      "y" : 1322,
      "width" : 54,
      "height" : 25
    },
    "textPosition" : {
      "x" : 649,
      "y" : 1324
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 694,
          "y" : 1322
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 694,
          "y" : 1322
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 3527,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 650,
          "y" : 1350
        },
        "to" : {
          "x" : 610,
          "y" : 1377
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3530,
    "reactomeId" : 11075946,
    "displayName" : "FKBP1A:tacrolimus",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 497,
      "y" : 1372
    },
    "minX" : 455,
    "maxX" : 545,
    "minY" : 1348,
    "maxY" : 1390,
    "prop" : {
      "x" : 455,
      "y" : 1354,
      "width" : 84,
      "height" : 36
    },
    "textPosition" : {
      "x" : 460,
      "y" : 1355
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 539,
          "y" : 1354
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 539,
          "y" : 1354
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 3527,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 3521,
    "reactomeId" : 11062278,
    "displayName" : "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1256,
      "y" : 1334
    },
    "minX" : 1241,
    "maxX" : 1285,
    "minY" : 1312,
    "maxY" : 1348,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1241,
        "y" : 1312
      },
      "to" : {
        "x" : 1256,
        "y" : 1334
      }
    }, {
      "from" : {
        "x" : 1256,
        "y" : 1334
      },
      "to" : {
        "x" : 1285,
        "y" : 1348
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1277,
        "y" : 1349
      },
      "b" : {
        "x" : 1285,
        "y" : 1348
      },
      "c" : {
        "x" : 1280,
        "y" : 1341
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1280,
        "y" : 1341
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1256,
        "y" : 1334
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1256,
        "y" : 1334
      }
    },
    "inputs" : [ {
      "id" : 3522,
      "points" : [ {
        "x" : 1309,
        "y" : 1073
      }, {
        "x" : 1493,
        "y" : 1083
      }, {
        "x" : 1488,
        "y" : 1291
      } ]
    }, {
      "id" : 3523,
      "points" : [ {
        "x" : 788,
        "y" : 1059
      }, {
        "x" : 1022,
        "y" : 1315
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 3524,
      "points" : [ {
        "x" : 1137,
        "y" : 1277
      } ]
    }, {
      "id" : 3525,
      "points" : [ {
        "x" : 1248,
        "y" : 1297
      } ]
    } ],
    "outputs" : [ {
      "id" : 3526
    } ]
  }, {
    "id" : 3527,
    "reactomeId" : 11075948,
    "displayName" : "FKBP1A binds tacrolimus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 586,
      "y" : 1371
    },
    "minX" : 542,
    "maxX" : 610,
    "minY" : 1365,
    "maxY" : 1377,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 610,
        "y" : 1377
      },
      "to" : {
        "x" : 586,
        "y" : 1371
      }
    }, {
      "from" : {
        "x" : 586,
        "y" : 1371
      },
      "to" : {
        "x" : 542,
        "y" : 1371
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 549,
        "y" : 1367
      },
      "b" : {
        "x" : 542,
        "y" : 1371
      },
      "c" : {
        "x" : 549,
        "y" : 1375
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 549,
        "y" : 1375
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 586,
        "y" : 1371
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 586,
        "y" : 1371
      }
    },
    "inputs" : [ {
      "id" : 3528,
      "points" : [ {
        "x" : 651,
        "y" : 1389
      } ]
    }, {
      "id" : 3529,
      "points" : [ {
        "x" : 650,
        "y" : 1350
      } ]
    } ],
    "outputs" : [ {
      "id" : 3530
    } ]
  } ],
  "compartments" : [ {
    "id" : 3542,
    "reactomeId" : 876,
    "displayName" : "plasma membrane",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1384,
      "y" : 940
    },
    "minX" : 1204,
    "maxX" : 1564,
    "minY" : 0,
    "maxY" : 1880,
    "prop" : {
      "x" : 1204,
      "y" : 0,
      "width" : 360,
      "height" : 1880
    },
    "textPosition" : {
      "x" : 1207,
      "y" : 1839
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 3525, 3521, 3526, 3522, 3558, 3560, 3577 ]
  }, {
    "id" : 3531,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 601,
      "y" : 936
    },
    "minX" : 0,
    "maxX" : 1202,
    "minY" : 0,
    "maxY" : 1872,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1202,
      "height" : 1872
    },
    "textPosition" : {
      "x" : 88,
      "y" : 1812
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1182,
      "height" : 1852
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 3532, 3533, 3523, 3524, 3530, 3527, 3529, 3528 ]
  }, {
    "id" : 3532,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 328,
      "y" : 1572
    },
    "minX" : 189,
    "maxX" : 467,
    "minY" : 1490,
    "maxY" : 1655,
    "prop" : {
      "x" : 189,
      "y" : 1490,
      "width" : 278,
      "height" : 165
    },
    "textPosition" : {
      "x" : 204,
      "y" : 1609
    },
    "insets" : {
      "x" : 199,
      "y" : 1500,
      "width" : 258,
      "height" : 145
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 3533,
    "reactomeId" : 17957,
    "displayName" : "endoplasmic reticulum lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 350,
      "y" : 802
    },
    "minX" : 101,
    "maxX" : 600,
    "minY" : 656,
    "maxY" : 948,
    "prop" : {
      "x" : 101,
      "y" : 656,
      "width" : 499,
      "height" : 292
    },
    "textPosition" : {
      "x" : 157,
      "y" : 812
    },
    "insets" : {
      "x" : 111,
      "y" : 666,
      "width" : 479,
      "height" : 272
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 3577,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1309,
      "y" : 825
    },
    "minX" : 1285,
    "maxX" : 1334,
    "minY" : 819,
    "maxY" : 831,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1285,
        "y" : 823
      },
      "to" : {
        "x" : 1334,
        "y" : 828
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1327,
        "y" : 831
      },
      "b" : {
        "x" : 1334,
        "y" : 828
      },
      "c" : {
        "x" : 1328,
        "y" : 823
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1328,
        "y" : 823
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1303,
        "y" : 819
      },
      "b" : {
        "x" : 1315,
        "y" : 831
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1309,
        "y" : 825
      }
    },
    "inputs" : [ {
      "id" : 3558
    } ],
    "outputs" : [ {
      "id" : 3560
    } ]
  } ],
  "shadows" : [ {
    "id" : 3578,
    "reactomeId" : 11079251,
    "displayName" : "Downstream signaling events of B Cell Receptor (BCR)",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 913,
      "y" : 1222
    },
    "minX" : 445,
    "maxX" : 1381,
    "minY" : 1016,
    "maxY" : 1428,
    "prop" : {
      "x" : 445,
      "y" : 1016,
      "width" : 936,
      "height" : 412
    },
    "points" : [ {
      "x" : 445,
      "y" : 1016
    }, {
      "x" : 1381,
      "y" : 1016
    }, {
      "x" : 1381,
      "y" : 1428
    }, {
      "x" : 445,
      "y" : 1428
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 1564,
  "minY" : 0,
  "maxY" : 1880,
  "disease" : false
}