{
  "dbId" : 11079253,
  "stId" : "R-SPO-983705",
  "speciesName" : "Schizosaccharomyces pombe",
  "nodes" : [ {
    "dbId" : 74016,
    "stId" : "R-ALL-74016",
    "displayName" : "Ca2+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 3523 ],
    "identifier" : "29108",
    "standardIdentifier" : "chebi:29108",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 11075946,
    "stId" : "R-SPO-2026019",
    "displayName" : "FKBP1A:tacrolimus [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68324,
    "diagramIds" : [ 3530 ],
    "parents" : [ ],
    "children" : [ 11075895, 9678991 ]
  }, {
    "dbId" : 11056064,
    "stId" : "R-SPO-58198",
    "displayName" : "PRKCB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68324,
    "identifier" : "P36582",
    "standardIdentifier" : "uniprot:P36582",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11056068 ],
    "children" : [ ]
  }, {
    "dbId" : 11056066,
    "stId" : "R-SPO-58198-2",
    "displayName" : "PRKCB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68324,
    "identifier" : "P36583",
    "standardIdentifier" : "uniprot:P36583",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11056068 ],
    "children" : [ ]
  }, {
    "dbId" : 140648,
    "stId" : "R-ALL-140648",
    "displayName" : "Ca2+ [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "29108",
    "standardIdentifier" : "chebi:29108",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 11056088 ],
    "children" : [ ]
  }, {
    "dbId" : 11056068,
    "stId" : "R-SPO-58198-3",
    "displayName" : "Homologues of PRKCB [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68324,
    "diagramIds" : [ 3524 ],
    "parents" : [ ],
    "children" : [ 11056066, 11056064 ]
  }, {
    "dbId" : 11056088,
    "stId" : "R-SPO-139829",
    "displayName" : "Activated PKC beta [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68324,
    "diagramIds" : [ 3526 ],
    "parents" : [ ],
    "children" : [ 11056086, 140648, 33625, 114519 ]
  }, {
    "dbId" : 11078911,
    "stId" : "R-SPO-1257604",
    "displayName" : "PIP3 activates AKT signaling",
    "schemaClass" : "Pathway",
    "speciesId" : 68324,
    "diagramIds" : [ 3560 ]
  }, {
    "dbId" : 114519,
    "stId" : "R-ALL-114519",
    "displayName" : "DAG [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 3522 ],
    "identifier" : "17815",
    "standardIdentifier" : "chebi:17815",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 11056088 ],
    "children" : [ ]
  }, {
    "dbId" : 33625,
    "stId" : "R-ALL-33625",
    "displayName" : "PS [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 3525 ],
    "identifier" : "11750",
    "standardIdentifier" : "chebi:11750",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 11056088 ],
    "children" : [ ]
  }, {
    "dbId" : 11056082,
    "stId" : "R-SPO-156467",
    "displayName" : "PRKCB [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68324,
    "identifier" : "P36582",
    "standardIdentifier" : "uniprot:P36582",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11056086 ],
    "children" : [ ]
  }, {
    "dbId" : 11056084,
    "stId" : "R-SPO-156467-2",
    "displayName" : "PRKCB [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68324,
    "identifier" : "P36583",
    "standardIdentifier" : "uniprot:P36583",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11056086 ],
    "children" : [ ]
  }, {
    "dbId" : 9678991,
    "stId" : "R-ALL-9678991",
    "displayName" : "tacrolimus [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "diagramIds" : [ 3528 ],
    "identifier" : "6784",
    "standardIdentifier" : "iuphar.ligand:6784",
    "chebiIdentifier" : "chebi:93221",
    "parents" : [ 11075946 ],
    "children" : [ ]
  }, {
    "dbId" : 11056086,
    "stId" : "R-SPO-156467-3",
    "displayName" : "Homologues of PRKCB [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68324,
    "parents" : [ 11056088 ],
    "children" : [ 11056084, 11056082 ]
  }, {
    "dbId" : 11075895,
    "stId" : "R-SPO-2026007",
    "displayName" : "fkh1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68324,
    "diagramIds" : [ 3529 ],
    "identifier" : "O42993",
    "standardIdentifier" : "uniprot:O42993",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "fkh1" ],
    "parents" : [ 11075946 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 11075948,
    "stId" : "R-SPO-9690461",
    "displayName" : "FKBP1A binds tacrolimus",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 11075895, 9678991 ],
    "outputs" : [ 11075946 ],
    "efs" : [ ],
    "diagramIds" : [ 3527 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 11062278,
    "stId" : "R-SPO-1168373",
    "displayName" : "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 11056068, 33625, 114519, 74016 ],
    "outputs" : [ 11056088 ],
    "efs" : [ ],
    "diagramIds" : [ 3521 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 11079249,
    "stId" : "R-SPO-1169091",
    "displayName" : "Activation of NF-kappaB in B cells",
    "events" : [ 11062278 ]
  }, {
    "dbId" : 11079251,
    "stId" : "R-SPO-1168372",
    "displayName" : "Downstream signaling events of B Cell Receptor (BCR)",
    "events" : [ 11062278, 11075948 ]
  }, {
    "dbId" : 11079845,
    "stId" : "R-SPO-2025928",
    "displayName" : "Calcineurin activates NFAT",
    "events" : [ 11075948 ]
  } ]
}