{ "dbId" : 11079187, "stableId" : "R-SPO-525793", "displayName" : "Myogenesis", "nodes" : [ { "id" : 25541, "reactomeId" : 11060915, "displayName" : "MEF2 proteins", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 706, "y" : 335 }, "minX" : 608, "maxX" : 755, "minY" : 271, "maxY" : 346, "prop" : { "x" : 657, "y" : 324, "width" : 98, "height" : 22 }, "textPosition" : { "x" : 657, "y" : 324 }, "connectors" : [ { "edgeId" : 25540, "type" : "INPUT", "segments" : [ { "from" : { "x" : 689, "y" : 318 }, "to" : { "x" : 608, "y" : 271 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 25542, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 629, "y" : 328 }, "minX" : 608, "maxX" : 650, "minY" : 271, "maxY" : 343, "prop" : { "x" : 610, "y" : 313, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 614, "y" : 317 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 644, "y" : 318 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 644, "y" : 318 } } }, "connectors" : [ { "edgeId" : 25540, "type" : "INPUT", "segments" : [ { "from" : { "x" : 623, "y" : 310 }, "to" : { "x" : 608, "y" : 271 } } ], "stoichiometry" : { "value" : 5, "shape" : { "a" : { "x" : 609, "y" : 284 }, "b" : { "x" : 621, "y" : 296 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 615, "y" : 290 } } } } ] }, { "id" : 25543, "reactomeId" : 11060919, "displayName" : "phospho-p38 alpha/beta/gamma MAPK", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 718, "y" : 272 }, "minX" : 557, "maxX" : 781, "minY" : 237, "maxY" : 297, "prop" : { "x" : 656, "y" : 247, "width" : 125, "height" : 50 }, "textPosition" : { "x" : 659, "y" : 247 }, "connectors" : [ { "edgeId" : 25540, "type" : "INPUT", "segments" : [ { "from" : { "x" : 650, "y" : 271 }, "to" : { "x" : 608, "y" : 271 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 25540, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 650, "y" : 257 }, "to" : { "x" : 562, "y" : 237 } }, { "from" : { "x" : 562, "y" : 237 }, "to" : { "x" : 561, "y" : 255 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 561, "y" : 259 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 561, "y" : 259 } } } ] }, { "id" : 25544, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 459, "y" : 334 }, "minX" : 439, "maxX" : 518, "minY" : 271, "maxY" : 349, "prop" : { "x" : 439, "y" : 319, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 442, "y" : 323 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 474, "y" : 324 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 474, "y" : 324 } } }, "connectors" : [ { "edgeId" : 25540, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 473, "y" : 316 }, "to" : { "x" : 518, "y" : 271 } } ], "stoichiometry" : { "value" : 5, "shape" : { "a" : { "x" : 489, "y" : 287 }, "b" : { "x" : 501, "y" : 299 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 495, "y" : 293 } } }, "endShape" : { "a" : { "x" : 475, "y" : 308 }, "b" : { "x" : 473, "y" : 316 }, "c" : { "x" : 481, "y" : 314 }, "type" : "ARROW", "centre" : { "x" : 481, "y" : 314 } } } ] }, { "id" : 25545, "reactomeId" : 11060939, "displayName" : "phospho p38:phospho MEF2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 425, "y" : 272 }, "minX" : 375, "maxX" : 518, "minY" : 248, "maxY" : 290, "prop" : { "x" : 375, "y" : 254, "width" : 101, "height" : 36 }, "textPosition" : { "x" : 375, "y" : 255 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 476, "y" : 254 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 476, "y" : 254 } } }, "connectors" : [ { "edgeId" : 25540, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 479, "y" : 271 }, "to" : { "x" : 518, "y" : 271 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 486, "y" : 267 }, "b" : { "x" : 479, "y" : 271 }, "c" : { "x" : 486, "y" : 275 }, "type" : "ARROW", "centre" : { "x" : 486, "y" : 275 } } } ] }, { "id" : 25551, "reactomeId" : 11060937, "displayName" : "phospho-MEF2 proteins", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 294, "y" : 238 }, "minX" : 244, "maxX" : 344, "minY" : 220, "maxY" : 256, "prop" : { "x" : 244, "y" : 220, "width" : 100, "height" : 36 }, "textPosition" : { "x" : 242, "y" : 220 }, "connectors" : [ ] } ], "edges" : [ { "id" : 25540, "reactomeId" : 11060942, "displayName" : "Phosphorylation of MEF2 proteins by p38", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 561, "y" : 271 }, "minX" : 518, "maxX" : 608, "minY" : 265, "maxY" : 277, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 608, "y" : 271 }, "to" : { "x" : 561, "y" : 271 } }, { "from" : { "x" : 561, "y" : 271 }, "to" : { "x" : 518, "y" : 271 } } ], "reactionShape" : { "a" : { "x" : 555, "y" : 265 }, "b" : { "x" : 567, "y" : 277 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 561, "y" : 271 } }, "inputs" : [ { "id" : 25541, "points" : [ { "x" : 689, "y" : 318 } ] }, { "id" : 25542, "points" : [ { "x" : 623, "y" : 310 } ], "stoichiometry" : 5 }, { "id" : 25543, "points" : [ { "x" : 650, "y" : 271 } ] } ], "outputs" : [ { "id" : 25544, "points" : [ { "x" : 473, "y" : 316 } ], "stoichiometry" : 5 }, { "id" : 25545, "points" : [ { "x" : 479, "y" : 271 } ] } ], "catalysts" : [ { "id" : 25543, "points" : [ { "x" : 650, "y" : 257 }, { "x" : 562, "y" : 237 } ] } ] } ], "compartments" : [ { "id" : 25552, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 456, "y" : 254 }, "minX" : 26, "maxX" : 887, "minY" : 93, "maxY" : 416, "prop" : { "x" : 26, "y" : 93, "width" : 861, "height" : 323 }, "textPosition" : { "x" : 768, "y" : 370 }, "insets" : { "x" : 36, "y" : 103, "width" : 841, "height" : 303 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 25543, 25540, 25541, 25542, 25544, 25545, 25551, 25556 ] }, { "id" : 25547, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 664, "y" : 273 }, "minX" : 0, "maxX" : 1328, "minY" : 0, "maxY" : 547, "prop" : { "x" : 0, "y" : 0, "width" : 1328, "height" : 547 }, "textPosition" : { "x" : 1009, "y" : 489 }, "insets" : { "x" : 10, "y" : 10, "width" : 1308, "height" : 527 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 25552 ] } ], "notes" : [ ], "links" : [ { "id" : 25555, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 505, "y" : 283 }, "minX" : 350, "maxX" : 660, "minY" : 248, "maxY" : 318, "segments" : [ { "from" : { "x" : 660, "y" : 318 }, "to" : { "x" : 350, "y" : 248 } } ], "reactionShape" : { "a" : { "x" : 499, "y" : 277 }, "b" : { "x" : 511, "y" : 289 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 505, "y" : 283 } }, "inputs" : [ { "id" : 25541 } ], "outputs" : [ { "id" : 25551 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 1328, "minY" : 0, "maxY" : 547, "disease" : false }