{ "dbId" : 11078967, "stableId" : "R-SPO-202403", "displayName" : "TCR signaling", "nodes" : [ { "id" : 63265, "reactomeId" : 11058482, "displayName" : "p-Y90-PKC-theta:DAG", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3161, "y" : 537 }, "minX" : 3103, "maxX" : 3226, "minY" : 488, "maxY" : 555, "prop" : { "x" : 3103, "y" : 519, "width" : 117, "height" : 36 }, "textPosition" : { "x" : 3105, "y" : 520 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3220, "y" : 519 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3220, "y" : 519 } } }, "connectors" : [ { "edgeId" : 63264, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3152, "y" : 516 }, "to" : { "x" : 3137, "y" : 488 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 63266, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3064, "y" : 514 }, "minX" : 3044, "maxX" : 3137, "minY" : 488, "maxY" : 529, "prop" : { "x" : 3044, "y" : 499, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 3048, "y" : 503 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3079, "y" : 504 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3079, "y" : 504 } } }, "connectors" : [ { "edgeId" : 63264, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3087, "y" : 506 }, "to" : { "x" : 3137, "y" : 488 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 3106, "y" : 491 }, "b" : { "x" : 3118, "y" : 503 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3112, "y" : 497 } } } } ] }, { "id" : 63267, "reactomeId" : 11058496, "displayName" : "Active PKC theta bound to DAG", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3163, "y" : 394 }, "minX" : 3106, "maxX" : 3227, "minY" : 370, "maxY" : 436, "prop" : { "x" : 3106, "y" : 376, "width" : 115, "height" : 36 }, "textPosition" : { "x" : 3106, "y" : 377 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3221, "y" : 376 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3221, "y" : 376 } } }, "connectors" : [ { "edgeId" : 63264, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3151, "y" : 415 }, "to" : { "x" : 3137, "y" : 436 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3150, "y" : 423 }, "b" : { "x" : 3151, "y" : 415 }, "c" : { "x" : 3144, "y" : 419 }, "type" : "ARROW", "centre" : { "x" : 3144, "y" : 419 } } } ] }, { "id" : 63268, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3063, "y" : 404 }, "minX" : 3043, "maxX" : 3137, "minY" : 388, "maxY" : 436, "prop" : { "x" : 3043, "y" : 389, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 3047, "y" : 393 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3079, "y" : 394 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3079, "y" : 394 } } }, "connectors" : [ { "edgeId" : 63264, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3087, "y" : 412 }, "to" : { "x" : 3137, "y" : 436 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 3106, "y" : 418 }, "b" : { "x" : 3118, "y" : 430 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3112, "y" : 424 } } }, "endShape" : { "a" : { "x" : 3095, "y" : 411 }, "b" : { "x" : 3087, "y" : 412 }, "c" : { "x" : 3092, "y" : 419 }, "type" : "ARROW", "centre" : { "x" : 3092, "y" : 419 } } } ] }, { "id" : 63248, "reactomeId" : 179856, "displayName" : "PI(4,5)P2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2093, "y" : 1726 }, "minX" : 2058, "maxX" : 2141, "minY" : 1657, "maxY" : 1764, "prop" : { "x" : 2058, "y" : 1711, "width" : 70, "height" : 30 }, "textPosition" : { "x" : 2060, "y" : 1715 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2123, "y" : 1716 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2123, "y" : 1716 } } }, "connectors" : [ { "edgeId" : 63251, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2103, "y" : 1708 }, "to" : { "x" : 2141, "y" : 1657 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 63247, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2100, "y" : 1744 }, "to" : { "x" : 2113, "y" : 1764 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 63249, "reactomeId" : 11058514, "displayName" : "phospho-p-Y771,Y783,Y1254-PLCG1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1951, "y" : 1733 }, "minX" : 1896, "maxX" : 2113, "minY" : 1702, "maxY" : 1764, "prop" : { "x" : 1896, "y" : 1708, "width" : 111, "height" : 51 }, "textPosition" : { "x" : 1906, "y" : 1709 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2007, "y" : 1708 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2007, "y" : 1708 } } }, "connectors" : [ { "edgeId" : 63247, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2010, "y" : 1743 }, "to" : { "x" : 2113, "y" : 1764 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 63250, "reactomeId" : 11058519, "displayName" : "Activated PLC gamma1 bound to PIP2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2257, "y" : 1732 }, "minX" : 2197, "maxX" : 2323, "minY" : 1701, "maxY" : 1757, "prop" : { "x" : 2197, "y" : 1707, "width" : 120, "height" : 50 }, "textPosition" : { "x" : 2202, "y" : 1708 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2317, "y" : 1707 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2317, "y" : 1707 } } }, "connectors" : [ { "edgeId" : 63247, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 63252, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2110, "y" : 1637 }, "minX" : 2089, "maxX" : 2141, "minY" : 1621, "maxY" : 1657, "prop" : { "x" : 2089, "y" : 1622, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 2093, "y" : 1626 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2127, "y" : 1627 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2127, "y" : 1627 } } }, "connectors" : [ { "edgeId" : 63251, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2135, "y" : 1650 }, "to" : { "x" : 2141, "y" : 1657 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 63253, "reactomeId" : 112275, "displayName" : "DAGs", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2445, "y" : 1724 }, "minX" : 2355, "maxX" : 2471, "minY" : 1658, "maxY" : 1739, "prop" : { "x" : 2421, "y" : 1709, "width" : 49, "height" : 30 }, "textPosition" : { "x" : 2425, "y" : 1713 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2465, "y" : 1714 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2465, "y" : 1714 } } }, "connectors" : [ { "edgeId" : 63251, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2424, "y" : 1706 }, "to" : { "x" : 2355, "y" : 1658 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2416, "y" : 1705 }, "b" : { "x" : 2424, "y" : 1706 }, "c" : { "x" : 2421, "y" : 1699 }, "type" : "ARROW", "centre" : { "x" : 2421, "y" : 1699 } } } ] }, { "id" : 63318, "reactomeId" : 11078911, "displayName" : "PIP3 activates AKT signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2930, "y" : 1399 }, "minX" : 2862, "maxX" : 2999, "minY" : 1371, "maxY" : 1427, "prop" : { "x" : 2862, "y" : 1371, "width" : 137, "height" : 56 }, "textPosition" : { "x" : 2863, "y" : 1377 }, "connectors" : [ ] }, { "id" : 63254, "reactomeId" : 114520, "displayName" : "I(1,4,5)P3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2425, "y" : 1598 }, "minX" : 2355, "maxX" : 2464, "minY" : 1582, "maxY" : 1658, "prop" : { "x" : 2388, "y" : 1583, "width" : 75, "height" : 30 }, "textPosition" : { "x" : 2391, "y" : 1587 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2458, "y" : 1588 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2458, "y" : 1588 } } }, "connectors" : [ { "edgeId" : 63251, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2407, "y" : 1616 }, "to" : { "x" : 2355, "y" : 1658 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2404, "y" : 1623 }, "b" : { "x" : 2407, "y" : 1616 }, "c" : { "x" : 2399, "y" : 1617 }, "type" : "ARROW", "centre" : { "x" : 2399, "y" : 1617 } } } ] }, { "id" : 63286, "reactomeId" : 179838, "displayName" : "PI(3,4,5)P3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3164, "y" : 1375 }, "minX" : 3123, "maxX" : 3206, "minY" : 1359, "maxY" : 1390, "prop" : { "x" : 3123, "y" : 1360, "width" : 82, "height" : 30 }, "textPosition" : { "x" : 3125, "y" : 1364 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3200, "y" : 1365 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3200, "y" : 1365 } } }, "connectors" : [ ] }, { "id" : 63255, "reactomeId" : 11058528, "displayName" : "p-PLCG", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2375, "y" : 1730 }, "minX" : 2309, "maxX" : 2402, "minY" : 1662, "maxY" : 1741, "prop" : { "x" : 2349, "y" : 1719, "width" : 53, "height" : 22 }, "textPosition" : { "x" : 2350, "y" : 1719 }, "connectors" : [ { "edgeId" : 63251, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2364, "y" : 1713 }, "to" : { "x" : 2316, "y" : 1669 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2313, "y" : 1666 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2313, "y" : 1666 } } } ] }, { "id" : 63288, "reactomeId" : 202247, "displayName" : "PI(3,4)P2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3163, "y" : 1188 }, "minX" : 3128, "maxX" : 3199, "minY" : 1172, "maxY" : 1203, "prop" : { "x" : 3128, "y" : 1173, "width" : 70, "height" : 30 }, "textPosition" : { "x" : 3130, "y" : 1177 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3193, "y" : 1178 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3193, "y" : 1178 } } }, "connectors" : [ ] }, { "id" : 63257, "reactomeId" : 202277, "displayName" : "PIP3, PI(3,4)P2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3163, "y" : 1051 }, "minX" : 3113, "maxX" : 3214, "minY" : 1018, "maxY" : 1062, "prop" : { "x" : 3113, "y" : 1040, "width" : 101, "height" : 22 }, "textPosition" : { "x" : 3113, "y" : 1040 }, "connectors" : [ { "edgeId" : 63256, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3152, "y" : 1034 }, "to" : { "x" : 3131, "y" : 1018 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 63258, "reactomeId" : 11058466, "displayName" : "PDPK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3059, "y" : 1051 }, "minX" : 3035, "maxX" : 3131, "minY" : 1018, "maxY" : 1062, "prop" : { "x" : 3035, "y" : 1040, "width" : 48, "height" : 22 }, "textPosition" : { "x" : 3035, "y" : 1040 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3083, "y" : 1040 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3083, "y" : 1040 } } }, "connectors" : [ { "edgeId" : 63256, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3083, "y" : 1037 }, "to" : { "x" : 3131, "y" : 1018 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 63259, "reactomeId" : 11058468, "displayName" : "PDK1:PIP2,PIP3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3164, "y" : 866 }, "minX" : 3113, "maxX" : 3242, "minY" : 460, "maxY" : 877, "prop" : { "x" : 3113, "y" : 855, "width" : 103, "height" : 22 }, "textPosition" : { "x" : 3113, "y" : 856 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3216, "y" : 855 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3216, "y" : 855 } } }, "connectors" : [ { "edgeId" : 63264, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3180, "y" : 852 }, "to" : { "x" : 3242, "y" : 815 } }, { "from" : { "x" : 3242, "y" : 815 }, "to" : { "x" : 3239, "y" : 461 } }, { "from" : { "x" : 3239, "y" : 461 }, "to" : { "x" : 3153, "y" : 464 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3149, "y" : 464 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3149, "y" : 464 } } }, { "edgeId" : 63256, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 63261, "reactomeId" : 11058374, "displayName" : "Homologues of PRKCQ", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3048, "y" : 807 }, "minX" : 3001, "maxX" : 3143, "minY" : 778, "maxY" : 825, "prop" : { "x" : 3001, "y" : 789, "width" : 94, "height" : 36 }, "textPosition" : { "x" : 3003, "y" : 789 }, "connectors" : [ { "edgeId" : 63260, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3098, "y" : 792 }, "to" : { "x" : 3143, "y" : 778 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 63262, "reactomeId" : 112275, "displayName" : "DAGs", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3165, "y" : 814 }, "minX" : 3141, "maxX" : 3191, "minY" : 778, "maxY" : 829, "prop" : { "x" : 3141, "y" : 799, "width" : 49, "height" : 30 }, "textPosition" : { "x" : 3145, "y" : 803 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3185, "y" : 804 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3185, "y" : 804 } } }, "connectors" : [ { "edgeId" : 63260, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3155, "y" : 796 }, "to" : { "x" : 3143, "y" : 778 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 63263, "reactomeId" : 11058507, "displayName" : "PKC-theta (open): DAG", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3153, "y" : 698 }, "minX" : 3095, "maxX" : 3218, "minY" : 674, "maxY" : 716, "prop" : { "x" : 3095, "y" : 680, "width" : 117, "height" : 36 }, "textPosition" : { "x" : 3111, "y" : 681 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3212, "y" : 680 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3212, "y" : 680 } } }, "connectors" : [ { "edgeId" : 63260, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 63264, "reactomeId" : 11058499, "displayName" : "Phosphorylation of PKC theta", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3137, "y" : 464 }, "minX" : 3131, "maxX" : 3143, "minY" : 436, "maxY" : 488, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3137, "y" : 488 }, "to" : { "x" : 3137, "y" : 464 } }, { "from" : { "x" : 3137, "y" : 464 }, "to" : { "x" : 3137, "y" : 436 } } ], "reactionShape" : { "a" : { "x" : 3131, "y" : 458 }, "b" : { "x" : 3143, "y" : 470 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3137, "y" : 464 } }, "inputs" : [ { "id" : 63265, "points" : [ { "x" : 3152, "y" : 516 } ] }, { "id" : 63266, "points" : [ { "x" : 3087, "y" : 506 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 63267, "points" : [ { "x" : 3151, "y" : 415 } ] }, { "id" : 63268, "points" : [ { "x" : 3087, "y" : 412 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 63259, "points" : [ { "x" : 3180, "y" : 852 }, { "x" : 3242, "y" : 815 }, { "x" : 3239, "y" : 461 } ] } ] }, { "id" : 63251, "reactomeId" : 11058531, "displayName" : "PLC-gamma1 hydrolyses PIP2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2304, "y" : 1658 }, "minX" : 2141, "maxX" : 2355, "minY" : 1652, "maxY" : 1664, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2141, "y" : 1657 }, "to" : { "x" : 2304, "y" : 1658 } }, { "from" : { "x" : 2304, "y" : 1658 }, "to" : { "x" : 2355, "y" : 1658 } } ], "reactionShape" : { "a" : { "x" : 2298, "y" : 1652 }, "b" : { "x" : 2310, "y" : 1664 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2304, "y" : 1658 } }, "inputs" : [ { "id" : 63248, "points" : [ { "x" : 2103, "y" : 1708 } ] }, { "id" : 63252, "points" : [ { "x" : 2135, "y" : 1650 } ] } ], "outputs" : [ { "id" : 63253, "points" : [ { "x" : 2424, "y" : 1706 } ] }, { "id" : 63254, "points" : [ { "x" : 2407, "y" : 1616 } ] } ], "catalysts" : [ { "id" : 63255, "points" : [ { "x" : 2364, "y" : 1713 } ] } ] }, { "id" : 63256, "reactomeId" : 11058470, "displayName" : "Translocation of PDK1 to Plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3131, "y" : 996 }, "minX" : 3125, "maxX" : 3161, "minY" : 880, "maxY" : 1018, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3131, "y" : 1018 }, "to" : { "x" : 3131, "y" : 996 } }, { "from" : { "x" : 3131, "y" : 996 }, "to" : { "x" : 3161, "y" : 880 } } ], "endShape" : { "a" : { "x" : 3163, "y" : 888 }, "b" : { "x" : 3161, "y" : 880 }, "c" : { "x" : 3155, "y" : 886 }, "type" : "ARROW", "centre" : { "x" : 3155, "y" : 886 } }, "reactionShape" : { "c" : { "x" : 3131, "y" : 996 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3131, "y" : 996 } }, "inputs" : [ { "id" : 63257, "points" : [ { "x" : 3152, "y" : 1034 } ] }, { "id" : 63258, "points" : [ { "x" : 3083, "y" : 1037 } ] } ], "outputs" : [ { "id" : 63259 } ] }, { "id" : 63260, "reactomeId" : 11058509, "displayName" : "Translocation of PKC theta to plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3143, "y" : 751 }, "minX" : 3137, "maxX" : 3149, "minY" : 719, "maxY" : 778, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3143, "y" : 778 }, "to" : { "x" : 3143, "y" : 751 } }, { "from" : { "x" : 3143, "y" : 751 }, "to" : { "x" : 3149, "y" : 719 } } ], "endShape" : { "a" : { "x" : 3152, "y" : 727 }, "b" : { "x" : 3149, "y" : 719 }, "c" : { "x" : 3144, "y" : 725 }, "type" : "ARROW", "centre" : { "x" : 3144, "y" : 725 } }, "reactionShape" : { "c" : { "x" : 3143, "y" : 751 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3143, "y" : 751 } }, "inputs" : [ { "id" : 63261, "points" : [ { "x" : 3098, "y" : 792 } ] }, { "id" : 63262, "points" : [ { "x" : 3155, "y" : 796 } ] } ], "outputs" : [ { "id" : 63263 } ] }, { "id" : 63247, "reactomeId" : 11058521, "displayName" : "Translocation of PLC-gamma1 to PIP2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2162, "y" : 1765 }, "minX" : 2113, "maxX" : 2194, "minY" : 1752, "maxY" : 1771, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2113, "y" : 1764 }, "to" : { "x" : 2162, "y" : 1765 } }, { "from" : { "x" : 2162, "y" : 1765 }, "to" : { "x" : 2194, "y" : 1752 } } ], "endShape" : { "a" : { "x" : 2189, "y" : 1758 }, "b" : { "x" : 2194, "y" : 1752 }, "c" : { "x" : 2186, "y" : 1751 }, "type" : "ARROW", "centre" : { "x" : 2186, "y" : 1751 } }, "reactionShape" : { "c" : { "x" : 2162, "y" : 1765 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2162, "y" : 1765 } }, "inputs" : [ { "id" : 63248, "points" : [ { "x" : 2100, "y" : 1744 } ] }, { "id" : 63249, "points" : [ { "x" : 2010, "y" : 1743 } ] } ], "outputs" : [ { "id" : 63250 } ] } ], "compartments" : [ { "id" : 63280, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1583, "y" : 867 }, "minX" : 0, "maxX" : 3166, "minY" : 0, "maxY" : 1734, "prop" : { "x" : 0, "y" : 0, "width" : 3166, "height" : 1734 }, "textPosition" : { "x" : 525, "y" : 1358 }, "insets" : { "x" : 10, "y" : 10, "width" : 3146, "height" : 1714 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 63249, 63248, 63250, 63251, 63252, 63253, 63286, 63288, 63256, 63257, 63258, 63259, 63260, 63261, 63263, 63262, 63265, 63264, 63266, 63267, 63268, 63254, 63319, 63321, 63325, 63312, 63318, 63327, 63255 ] }, { "id" : 63312, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1021, "y" : 579 }, "minX" : 908, "maxX" : 1134, "minY" : 502, "maxY" : 657, "prop" : { "x" : 908, "y" : 502, "width" : 226, "height" : 155 }, "textPosition" : { "x" : 978, "y" : 588 }, "insets" : { "x" : 918, "y" : 512, "width" : 206, "height" : 135 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } } ], "notes" : [ ], "links" : [ { "id" : 63323, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 3258, "y" : 1165 }, "minX" : 3170, "maxX" : 3264, "minY" : 1068, "maxY" : 1357, "segments" : [ { "from" : { "x" : 3170, "y" : 1357 }, "to" : { "x" : 3258, "y" : 1165 } }, { "from" : { "x" : 3258, "y" : 1165 }, "to" : { "x" : 3172, "y" : 1068 } } ], "reactionShape" : { "a" : { "x" : 3252, "y" : 1159 }, "b" : { "x" : 3264, "y" : 1171 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3258, "y" : 1165 } }, "inputs" : [ { "id" : 63286 } ], "outputs" : [ { "id" : 63257 } ] }, { "id" : 63324, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 3234, "y" : 1160 }, "minX" : 3170, "maxX" : 3240, "minY" : 1068, "maxY" : 1174, "segments" : [ { "from" : { "x" : 3201, "y" : 1174 }, "to" : { "x" : 3234, "y" : 1160 } }, { "from" : { "x" : 3234, "y" : 1160 }, "to" : { "x" : 3170, "y" : 1068 } } ], "reactionShape" : { "a" : { "x" : 3228, "y" : 1154 }, "b" : { "x" : 3240, "y" : 1166 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3234, "y" : 1160 } }, "inputs" : [ { "id" : 63288 } ], "outputs" : [ { "id" : 63257 } ] }, { "id" : 63327, "renderableClass" : "Interaction", "position" : { "x" : 3061, "y" : 1385 }, "minX" : 3002, "maxX" : 3120, "minY" : 1379, "maxY" : 1391, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3120, "y" : 1379 }, "to" : { "x" : 3002, "y" : 1391 } } ], "endShape" : { "a" : { "x" : 3008, "y" : 1386 }, "b" : { "x" : 3002, "y" : 1391 }, "c" : { "x" : 3009, "y" : 1394 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3009, "y" : 1394 } }, "reactionShape" : { "a" : { "x" : 3055, "y" : 1379 }, "b" : { "x" : 3067, "y" : 1391 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3061, "y" : 1385 } }, "inputs" : [ { "id" : 63286 } ], "outputs" : [ { "id" : 63318 } ] } ], "shadows" : [ { "id" : 63328, "reactomeId" : 11078965, "displayName" : "Downstream TCR signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 3111, "y" : 719 }, "minX" : 2991, "maxX" : 3231, "minY" : 366, "maxY" : 1072, "prop" : { "x" : 2991, "y" : 366, "width" : 240, "height" : 706 }, "points" : [ { "x" : 2991, "y" : 366 }, { "x" : 3231, "y" : 366 }, { "x" : 3231, "y" : 1072 }, { "x" : 2991, "y" : 1072 } ], "colour" : "#4684ee" }, { "id" : 63329, "reactomeId" : 11078975, "displayName" : "Generation of second messenger molecules", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2183, "y" : 1677 }, "minX" : 1886, "maxX" : 2480, "minY" : 1573, "maxY" : 1781, "prop" : { "x" : 1886, "y" : 1573, "width" : 594, "height" : 208 }, "points" : [ { "x" : 1886, "y" : 1573 }, { "x" : 2480, "y" : 1573 }, { "x" : 2480, "y" : 1781 }, { "x" : 1886, "y" : 1781 } ], "colour" : "#dc3912" } ], "minX" : 0, "maxX" : 3264, "minY" : 0, "maxY" : 1771, "disease" : false }