{
  "dbId" : 11078533,
  "stableId" : "R-SPO-74158",
  "displayName" : "RNA Polymerase III Transcription",
  "nodes" : [ {
    "id" : 13473,
    "reactomeId" : 83747,
    "displayName" : "DNA with RNA Polymerase III Type 2 Closed Promoter",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 508,
      "y" : 459
    },
    "minX" : 446,
    "maxX" : 611,
    "minY" : 434,
    "maxY" : 484,
    "prop" : {
      "x" : 446,
      "y" : 434,
      "width" : 124,
      "height" : 50
    },
    "textPosition" : {
      "x" : 458,
      "y" : 428
    },
    "connectors" : [ {
      "edgeId" : 13472,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 573,
          "y" : 457
        },
        "to" : {
          "x" : 611,
          "y" : 457
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13474,
    "reactomeId" : 11055116,
    "displayName" : "TFIIIC",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 598,
      "y" : 403
    },
    "minX" : 579,
    "maxX" : 624,
    "minY" : 386,
    "maxY" : 457,
    "prop" : {
      "x" : 579,
      "y" : 392,
      "width" : 39,
      "height" : 22
    },
    "textPosition" : {
      "x" : 579,
      "y" : 393
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 618,
          "y" : 392
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 618,
          "y" : 392
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13472,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 600,
          "y" : 417
        },
        "to" : {
          "x" : 611,
          "y" : 457
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13475,
    "reactomeId" : 11055350,
    "displayName" : "TFIIIC:Type 2 Promoter Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 755,
      "y" : 457
    },
    "minX" : 697,
    "maxX" : 862,
    "minY" : 433,
    "maxY" : 475,
    "prop" : {
      "x" : 697,
      "y" : 439,
      "width" : 116,
      "height" : 36
    },
    "textPosition" : {
      "x" : 711,
      "y" : 426
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 813,
          "y" : 439
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 813,
          "y" : 439
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13472,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 13476,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 816,
          "y" : 457
        },
        "to" : {
          "x" : 862,
          "y" : 457
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13477,
    "reactomeId" : 11055354,
    "displayName" : "TFIIIB:TFIIIC:Type 2 Promoter Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1032,
      "y" : 458
    },
    "minX" : 971,
    "maxX" : 1145,
    "minY" : 434,
    "maxY" : 476,
    "prop" : {
      "x" : 971,
      "y" : 440,
      "width" : 122,
      "height" : 36
    },
    "textPosition" : {
      "x" : 971,
      "y" : 441
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1093,
          "y" : 440
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1093,
          "y" : 440
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13476,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 13478,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1096,
          "y" : 458
        },
        "to" : {
          "x" : 1145,
          "y" : 458
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13479,
    "reactomeId" : 11055358,
    "displayName" : "RNA Polymerase III:TFIIIB:TFIIIC:Type 2 Promoter Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1276,
      "y" : 461
    },
    "minX" : 1215,
    "maxX" : 1343,
    "minY" : 430,
    "maxY" : 486,
    "prop" : {
      "x" : 1215,
      "y" : 436,
      "width" : 122,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1214,
      "y" : 423
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1337,
          "y" : 436
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1337,
          "y" : 436
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13478,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13466,
    "reactomeId" : 11055084,
    "displayName" : "TFIIIB-Type 1 and 2 Promoter Selective Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 834,
      "y" : 403
    },
    "minX" : 770,
    "maxX" : 904,
    "minY" : 344,
    "maxY" : 457,
    "prop" : {
      "x" : 770,
      "y" : 378,
      "width" : 128,
      "height" : 50
    },
    "textPosition" : {
      "x" : 769,
      "y" : 379
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 898,
          "y" : 378
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 898,
          "y" : 378
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13476,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 846,
          "y" : 431
        },
        "to" : {
          "x" : 862,
          "y" : 457
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 13465,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 848,
          "y" : 375
        },
        "to" : {
          "x" : 868,
          "y" : 344
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13467,
    "reactomeId" : 11055120,
    "displayName" : "TFIIIC:TFIIIA:Type I Promoter Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 772,
      "y" : 346
    },
    "minX" : 713,
    "maxX" : 868,
    "minY" : 322,
    "maxY" : 364,
    "prop" : {
      "x" : 713,
      "y" : 328,
      "width" : 118,
      "height" : 36
    },
    "textPosition" : {
      "x" : 713,
      "y" : 315
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 831,
          "y" : 328
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 831,
          "y" : 328
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13465,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 834,
          "y" : 344
        },
        "to" : {
          "x" : 868,
          "y" : 344
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13468,
    "reactomeId" : 11055122,
    "displayName" : "TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 991,
      "y" : 340
    },
    "minX" : 935,
    "maxX" : 1094,
    "minY" : 309,
    "maxY" : 365,
    "prop" : {
      "x" : 935,
      "y" : 315,
      "width" : 112,
      "height" : 50
    },
    "textPosition" : {
      "x" : 947,
      "y" : 302
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1047,
          "y" : 315
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1047,
          "y" : 315
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13465,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 13469,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1050,
          "y" : 340
        },
        "to" : {
          "x" : 1094,
          "y" : 340
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13470,
    "reactomeId" : 11055176,
    "displayName" : "RNA Polymerase III Holoenzyme",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1151,
      "y" : 384
    },
    "minX" : 1091,
    "maxX" : 1217,
    "minY" : 340,
    "maxY" : 458,
    "prop" : {
      "x" : 1091,
      "y" : 366,
      "width" : 120,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1094,
      "y" : 367
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1211,
          "y" : 366
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1211,
          "y" : 366
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13478,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1149,
          "y" : 405
        },
        "to" : {
          "x" : 1145,
          "y" : 458
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 13469,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1127,
          "y" : 363
        },
        "to" : {
          "x" : 1094,
          "y" : 340
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13471,
    "reactomeId" : 11055178,
    "displayName" : "RNA polymerase III:TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 998,
      "y" : 231
    },
    "minX" : 938,
    "maxX" : 1065,
    "minY" : 193,
    "maxY" : 263,
    "prop" : {
      "x" : 938,
      "y" : 199,
      "width" : 121,
      "height" : 64
    },
    "textPosition" : {
      "x" : 942,
      "y" : 186
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1059,
          "y" : 199
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1059,
          "y" : 199
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13469,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 13472,
    "reactomeId" : 11055352,
    "displayName" : "Binding of TFIIIC to Type 2 promoter",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 645,
      "y" : 458
    },
    "minX" : 611,
    "maxX" : 694,
    "minY" : 452,
    "maxY" : 464,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 611,
        "y" : 457
      },
      "to" : {
        "x" : 645,
        "y" : 458
      }
    }, {
      "from" : {
        "x" : 645,
        "y" : 458
      },
      "to" : {
        "x" : 694,
        "y" : 457
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 687,
        "y" : 461
      },
      "b" : {
        "x" : 694,
        "y" : 457
      },
      "c" : {
        "x" : 687,
        "y" : 453
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 687,
        "y" : 453
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 645,
        "y" : 458
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 645,
        "y" : 458
      }
    },
    "inputs" : [ {
      "id" : 13473,
      "points" : [ {
        "x" : 573,
        "y" : 457
      } ]
    }, {
      "id" : 13474,
      "points" : [ {
        "x" : 600,
        "y" : 417
      } ]
    } ],
    "outputs" : [ {
      "id" : 13475
    } ]
  }, {
    "id" : 13476,
    "reactomeId" : 11055356,
    "displayName" : "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 927,
      "y" : 458
    },
    "minX" : 862,
    "maxX" : 968,
    "minY" : 452,
    "maxY" : 464,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 862,
        "y" : 457
      },
      "to" : {
        "x" : 927,
        "y" : 458
      }
    }, {
      "from" : {
        "x" : 927,
        "y" : 458
      },
      "to" : {
        "x" : 968,
        "y" : 458
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 961,
        "y" : 462
      },
      "b" : {
        "x" : 968,
        "y" : 458
      },
      "c" : {
        "x" : 961,
        "y" : 454
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 961,
        "y" : 454
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 927,
        "y" : 458
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 927,
        "y" : 458
      }
    },
    "inputs" : [ {
      "id" : 13466,
      "points" : [ {
        "x" : 846,
        "y" : 431
      } ]
    }, {
      "id" : 13475,
      "points" : [ {
        "x" : 816,
        "y" : 457
      } ]
    } ],
    "outputs" : [ {
      "id" : 13477
    } ]
  }, {
    "id" : 13478,
    "reactomeId" : 11055360,
    "displayName" : "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1174,
      "y" : 459
    },
    "minX" : 1145,
    "maxX" : 1212,
    "minY" : 453,
    "maxY" : 465,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1145,
        "y" : 458
      },
      "to" : {
        "x" : 1174,
        "y" : 459
      }
    }, {
      "from" : {
        "x" : 1174,
        "y" : 459
      },
      "to" : {
        "x" : 1212,
        "y" : 459
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1205,
        "y" : 463
      },
      "b" : {
        "x" : 1212,
        "y" : 459
      },
      "c" : {
        "x" : 1205,
        "y" : 455
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1205,
        "y" : 455
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1174,
        "y" : 459
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1174,
        "y" : 459
      }
    },
    "inputs" : [ {
      "id" : 13470,
      "points" : [ {
        "x" : 1149,
        "y" : 405
      } ]
    }, {
      "id" : 13477,
      "points" : [ {
        "x" : 1096,
        "y" : 458
      } ]
    } ],
    "outputs" : [ {
      "id" : 13479
    } ]
  }, {
    "id" : 13465,
    "reactomeId" : 11055348,
    "displayName" : "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 902,
      "y" : 344
    },
    "minX" : 868,
    "maxX" : 932,
    "minY" : 338,
    "maxY" : 350,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 868,
        "y" : 344
      },
      "to" : {
        "x" : 902,
        "y" : 344
      }
    }, {
      "from" : {
        "x" : 902,
        "y" : 344
      },
      "to" : {
        "x" : 932,
        "y" : 342
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 925,
        "y" : 346
      },
      "b" : {
        "x" : 932,
        "y" : 342
      },
      "c" : {
        "x" : 925,
        "y" : 338
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 925,
        "y" : 338
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 902,
        "y" : 344
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 902,
        "y" : 344
      }
    },
    "inputs" : [ {
      "id" : 13466,
      "points" : [ {
        "x" : 848,
        "y" : 375
      } ]
    }, {
      "id" : 13467,
      "points" : [ {
        "x" : 834,
        "y" : 344
      } ]
    } ],
    "outputs" : [ {
      "id" : 13468
    } ]
  }, {
    "id" : 13469,
    "reactomeId" : 11055180,
    "displayName" : "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1093,
      "y" : 298
    },
    "minX" : 1043,
    "maxX" : 1099,
    "minY" : 266,
    "maxY" : 340,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1094,
        "y" : 340
      },
      "to" : {
        "x" : 1093,
        "y" : 298
      }
    }, {
      "from" : {
        "x" : 1093,
        "y" : 298
      },
      "to" : {
        "x" : 1043,
        "y" : 266
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1051,
        "y" : 266
      },
      "b" : {
        "x" : 1043,
        "y" : 266
      },
      "c" : {
        "x" : 1047,
        "y" : 273
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1047,
        "y" : 273
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1093,
        "y" : 298
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1093,
        "y" : 298
      }
    },
    "inputs" : [ {
      "id" : 13468,
      "points" : [ {
        "x" : 1050,
        "y" : 340
      } ]
    }, {
      "id" : 13470,
      "points" : [ {
        "x" : 1127,
        "y" : 363
      } ]
    } ],
    "outputs" : [ {
      "id" : 13471
    } ]
  } ],
  "compartments" : [ {
    "id" : 13485,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 916,
      "y" : 491
    },
    "minX" : 0,
    "maxX" : 1833,
    "minY" : 0,
    "maxY" : 982,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1833,
      "height" : 982
    },
    "textPosition" : {
      "x" : 117,
      "y" : 167
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1813,
      "height" : 962
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 13474, 13467, 13466, 13468, 13470, 13471, 13473, 13475, 13477, 13479, 13465, 13469, 13472, 13476, 13478 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ {
    "id" : 13486,
    "reactomeId" : 11078531,
    "displayName" : "RNA Polymerase III Transcription Initiation",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 891,
      "y" : 342
    },
    "minX" : 436,
    "maxX" : 1347,
    "minY" : 189,
    "maxY" : 496,
    "prop" : {
      "x" : 436,
      "y" : 189,
      "width" : 911,
      "height" : 307
    },
    "points" : [ {
      "x" : 436,
      "y" : 189
    }, {
      "x" : 1347,
      "y" : 189
    }, {
      "x" : 1347,
      "y" : 496
    }, {
      "x" : 436,
      "y" : 496
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 1833,
  "minY" : 0,
  "maxY" : 982,
  "disease" : false
}