{
  "dbId" : 11050882,
  "stId" : "R-DDI-201556",
  "speciesName" : "Dictyostelium discoideum",
  "nodes" : [ {
    "dbId" : 11049320,
    "stId" : "R-DDI-1489509",
    "displayName" : "DAG and IP3 signaling",
    "schemaClass" : "Pathway",
    "speciesId" : 170941,
    "diagramIds" : [ 83848 ]
  }, {
    "dbId" : 11045673,
    "stId" : "R-DDI-539048-5",
    "displayName" : "phospho-p-Y705,S727-STAT3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54WB7",
    "standardIdentifier" : "uniprot:Q54WB7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11045679 ],
    "children" : [ ]
  }, {
    "dbId" : 11022570,
    "stId" : "R-DDI-205135",
    "displayName" : "HDAC2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q55FN5",
    "standardIdentifier" : "uniprot:Q55FN5",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11045730 ],
    "children" : [ ]
  }, {
    "dbId" : 11045675,
    "stId" : "R-DDI-539048-6",
    "displayName" : "phospho-dstB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q70GP4",
    "standardIdentifier" : "uniprot:Q70GP4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "dstB" ],
    "parents" : [ 11045679 ],
    "children" : [ ]
  }, {
    "dbId" : 11050604,
    "stId" : "R-DDI-6806003",
    "displayName" : "Regulation of TP53 Expression and Degradation",
    "schemaClass" : "Pathway",
    "speciesId" : 170941,
    "diagramIds" : [ 83895 ]
  }, {
    "dbId" : 11045677,
    "stId" : "R-DDI-539048-7",
    "displayName" : "phospho-dstD [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q86I20",
    "standardIdentifier" : "uniprot:Q86I20",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "dstD" ],
    "parents" : [ 11045679 ],
    "children" : [ ]
  }, {
    "dbId" : 11045679,
    "stId" : "R-DDI-539048-8",
    "displayName" : "Homologues of p-Y705,S727-STAT3 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 170941,
    "diagramIds" : [ 83825 ],
    "parents" : [ 11045681 ],
    "children" : [ 11045671, 11045669, 11045667, 11045665, 11045677, 11045675, 11045673 ]
  }, {
    "dbId" : 11045728,
    "stId" : "R-DDI-9701465",
    "displayName" : "AcK685- p-Y705,S727-STAT3 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 170941,
    "diagramIds" : [ 83830 ],
    "parents" : [ ],
    "children" : [ 11045726 ]
  }, {
    "dbId" : 11045665,
    "stId" : "R-DDI-539048",
    "displayName" : "phospho-dstA [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "O00910",
    "standardIdentifier" : "uniprot:O00910",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "dstA" ],
    "parents" : [ 11045679 ],
    "children" : [ ]
  }, {
    "dbId" : 11045730,
    "stId" : "R-DDI-205005",
    "displayName" : "Histone deacetylase [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 170941,
    "diagramIds" : [ 83833 ],
    "parents" : [ ],
    "children" : [ 11015826, 11010035, 11022570 ]
  }, {
    "dbId" : 11045667,
    "stId" : "R-DDI-539048-2",
    "displayName" : "phospho-p-Y705,S727-STAT3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54B81",
    "standardIdentifier" : "uniprot:Q54B81",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11045679 ],
    "children" : [ ]
  }, {
    "dbId" : 11045669,
    "stId" : "R-DDI-539048-3",
    "displayName" : "phospho-dstC [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54BD4",
    "standardIdentifier" : "uniprot:Q54BD4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "dstC" ],
    "parents" : [ 11045679 ],
    "children" : [ ]
  }, {
    "dbId" : 11045671,
    "stId" : "R-DDI-539048-4",
    "displayName" : "phospho-p-Y705,S727-STAT3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54GL9",
    "standardIdentifier" : "uniprot:Q54GL9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11045679 ],
    "children" : [ ]
  }, {
    "dbId" : 11045689,
    "stId" : "R-DDI-9701429-3",
    "displayName" : "phospho-dstC [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54BD4",
    "standardIdentifier" : "uniprot:Q54BD4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "dstC" ],
    "parents" : [ 11045699 ],
    "children" : [ ]
  }, {
    "dbId" : 11045691,
    "stId" : "R-DDI-9701429-4",
    "displayName" : "phospho-p-Y705,S727-STAT3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54GL9",
    "standardIdentifier" : "uniprot:Q54GL9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11045699 ],
    "children" : [ ]
  }, {
    "dbId" : 11010035,
    "stId" : "R-DDI-442464",
    "displayName" : "HDAC3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q55BW2",
    "standardIdentifier" : "uniprot:Q55BW2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11045730 ],
    "children" : [ ]
  }, {
    "dbId" : 11045693,
    "stId" : "R-DDI-9701429-5",
    "displayName" : "phospho-p-Y705,S727-STAT3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54WB7",
    "standardIdentifier" : "uniprot:Q54WB7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11045699 ],
    "children" : [ ]
  }, {
    "dbId" : 11045695,
    "stId" : "R-DDI-9701429-6",
    "displayName" : "phospho-dstB [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q70GP4",
    "standardIdentifier" : "uniprot:Q70GP4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "dstB" ],
    "parents" : [ 11045699 ],
    "children" : [ ]
  }, {
    "dbId" : 11048880,
    "stId" : "R-DDI-453279",
    "displayName" : "Mitotic G1 phase and G1/S transition",
    "schemaClass" : "Pathway",
    "speciesId" : 170941,
    "diagramIds" : [ 83896 ]
  }, {
    "dbId" : 427486,
    "stId" : "R-ALL-427486",
    "displayName" : "CH3COO- [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 83832 ],
    "identifier" : "15366",
    "standardIdentifier" : "chebi:15366",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 11045681,
    "stId" : "R-DDI-9701454",
    "displayName" : "p-Y705,S727-STAT3 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 170941,
    "diagramIds" : [ 83826 ],
    "parents" : [ ],
    "children" : [ 11045679 ]
  }, {
    "dbId" : 11045685,
    "stId" : "R-DDI-9701429",
    "displayName" : "phospho-dstA [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "O00910",
    "standardIdentifier" : "uniprot:O00910",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "dstA" ],
    "parents" : [ 11045699 ],
    "children" : [ ]
  }, {
    "dbId" : 11045687,
    "stId" : "R-DDI-9701429-2",
    "displayName" : "phospho-p-Y705,S727-STAT3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54B81",
    "standardIdentifier" : "uniprot:Q54B81",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11045699 ],
    "children" : [ ]
  }, {
    "dbId" : 11045706,
    "stId" : "R-DDI-9701435",
    "displayName" : "phospho-dstA [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "O00910",
    "standardIdentifier" : "uniprot:O00910",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "dstA" ],
    "parents" : [ 11045726 ],
    "children" : [ ]
  }, {
    "dbId" : 11045709,
    "stId" : "R-DDI-9701435-2",
    "displayName" : "phospho-AcK685- p-Y705,S727-STAT3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54B81",
    "standardIdentifier" : "uniprot:Q54B81",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11045726 ],
    "children" : [ ]
  }, {
    "dbId" : 11045697,
    "stId" : "R-DDI-9701429-7",
    "displayName" : "phospho-dstD [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q86I20",
    "standardIdentifier" : "uniprot:Q86I20",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "dstD" ],
    "parents" : [ 11045699 ],
    "children" : [ ]
  }, {
    "dbId" : 11050498,
    "stId" : "R-DDI-5673001",
    "displayName" : "RAF/MAP kinase cascade",
    "schemaClass" : "Pathway",
    "speciesId" : 170941,
    "diagramIds" : [ 83841 ]
  }, {
    "dbId" : 11045699,
    "stId" : "R-DDI-9701429-8",
    "displayName" : "Homologues of p-Y705,S727-STAT3 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 170941,
    "parents" : [ 11045701 ],
    "children" : [ 11045687, 11045685, 11045697, 11045695, 11045693, 11045691, 11045689 ]
  }, {
    "dbId" : 11045701,
    "stId" : "R-DDI-9701457",
    "displayName" : "p-Y705,S727-STAT3 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 170941,
    "diagramIds" : [ 83828 ],
    "parents" : [ ],
    "children" : [ 11045699 ]
  }, {
    "dbId" : 113518,
    "stId" : "R-ALL-113518",
    "displayName" : "H2O [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 83831 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 11045721,
    "stId" : "R-DDI-9701435-6",
    "displayName" : "phospho-dstB [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q70GP4",
    "standardIdentifier" : "uniprot:Q70GP4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "dstB" ],
    "parents" : [ 11045726 ],
    "children" : [ ]
  }, {
    "dbId" : 11049626,
    "stId" : "R-DDI-1257604",
    "displayName" : "PIP3 activates AKT signaling",
    "schemaClass" : "Pathway",
    "speciesId" : 170941,
    "diagramIds" : [ 83844, 83884 ]
  }, {
    "dbId" : 11045724,
    "stId" : "R-DDI-9701435-7",
    "displayName" : "phospho-dstD [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q86I20",
    "standardIdentifier" : "uniprot:Q86I20",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "dstD" ],
    "parents" : [ 11045726 ],
    "children" : [ ]
  }, {
    "dbId" : 11045726,
    "stId" : "R-DDI-9701435-8",
    "displayName" : "Homologues of AcK685- p-Y705,S727-STAT3 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 170941,
    "parents" : [ 11045728 ],
    "children" : [ 11045718, 11045715, 11045712, 11045709, 11045724, 11045706, 11045721 ]
  }, {
    "dbId" : 11045712,
    "stId" : "R-DDI-9701435-3",
    "displayName" : "phospho-dstC [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54BD4",
    "standardIdentifier" : "uniprot:Q54BD4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "dstC" ],
    "parents" : [ 11045726 ],
    "children" : [ ]
  }, {
    "dbId" : 11015826,
    "stId" : "R-DDI-205021",
    "displayName" : "HDAC1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q55FN5",
    "standardIdentifier" : "uniprot:Q55FN5",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11045730 ],
    "children" : [ ]
  }, {
    "dbId" : 11045715,
    "stId" : "R-DDI-9701435-4",
    "displayName" : "phospho-AcK685- p-Y705,S727-STAT3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54GL9",
    "standardIdentifier" : "uniprot:Q54GL9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11045726 ],
    "children" : [ ]
  }, {
    "dbId" : 11050580,
    "stId" : "R-DDI-6783783",
    "displayName" : "Interleukin-10 signaling",
    "schemaClass" : "Pathway",
    "speciesId" : 170941,
    "diagramIds" : [ 83882 ]
  }, {
    "dbId" : 11045718,
    "stId" : "R-DDI-9701435-5",
    "displayName" : "phospho-AcK685- p-Y705,S727-STAT3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 170941,
    "identifier" : "Q54WB7",
    "standardIdentifier" : "uniprot:Q54WB7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 11045726 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 11045683,
    "stId" : "R-DDI-9701525",
    "displayName" : "p-Y705,S727-STAT3 dimerizes",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 11045703 ],
    "inputs" : [ 11045679 ],
    "outputs" : [ 11045681 ],
    "efs" : [ ],
    "diagramIds" : [ 83824 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 11045733,
    "stId" : "R-DDI-9701565",
    "displayName" : "HDACs deacetylate p-STAT3 dimers",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 113518, 11045728 ],
    "outputs" : [ 11045701, 427486 ],
    "catalysts" : [ 11045730 ],
    "efs" : [ ],
    "diagramIds" : [ 83829 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 11045703,
    "stId" : "R-DDI-9701529",
    "displayName" : "p-Y705, p-S727 STAT3 dimer translocates to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 11045683 ],
    "inputs" : [ 11045681 ],
    "outputs" : [ 11045701 ],
    "efs" : [ ],
    "diagramIds" : [ 83827 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 11050884,
    "stId" : "R-DDI-9701898",
    "displayName" : "STAT3 nuclear events downstream of ALK signaling",
    "events" : [ 11045733 ]
  } ]
}