{
  "dbId" : 11050848,
  "stableId" : "R-DDI-9648002",
  "displayName" : "RAS processing",
  "nodes" : [ {
    "id" : 96329,
    "reactomeId" : 11050498,
    "displayName" : "RAF/MAP kinase cascade",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 903,
      "y" : 156
    },
    "minX" : 837,
    "maxX" : 969,
    "minY" : 124,
    "maxY" : 189,
    "prop" : {
      "x" : 837,
      "y" : 124,
      "width" : 132,
      "height" : 65
    },
    "textPosition" : {
      "x" : 844,
      "y" : 135
    },
    "connectors" : [ ]
  }, {
    "id" : 96273,
    "reactomeId" : 2530486,
    "displayName" : "FPP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 234,
      "y" : 652
    },
    "minX" : 208,
    "maxX" : 263,
    "minY" : 607,
    "maxY" : 665,
    "prop" : {
      "x" : 208,
      "y" : 639,
      "width" : 53,
      "height" : 26
    },
    "textPosition" : {
      "x" : 219,
      "y" : 641
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 256,
          "y" : 644
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 256,
          "y" : 644
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96272,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 242,
          "y" : 636
        },
        "to" : {
          "x" : 263,
          "y" : 607
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96275,
    "reactomeId" : 111294,
    "displayName" : "PPi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 354,
      "y" : 664
    },
    "minX" : 328,
    "maxX" : 381,
    "minY" : 606,
    "maxY" : 679,
    "prop" : {
      "x" : 328,
      "y" : 649,
      "width" : 52,
      "height" : 30
    },
    "textPosition" : {
      "x" : 340,
      "y" : 653
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 375,
          "y" : 654
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 375,
          "y" : 654
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96272,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 354,
          "y" : 646
        },
        "to" : {
          "x" : 354,
          "y" : 606
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 350,
          "y" : 639
        },
        "b" : {
          "x" : 354,
          "y" : 646
        },
        "c" : {
          "x" : 358,
          "y" : 639
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 358,
          "y" : 639
        }
      }
    } ]
  }, {
    "id" : 96274,
    "reactomeId" : 11044639,
    "displayName" : "pro-RAS",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 185,
      "y" : 610
    },
    "minX" : 144,
    "maxX" : 263,
    "minY" : 599,
    "maxY" : 621,
    "prop" : {
      "x" : 144,
      "y" : 599,
      "width" : 82,
      "height" : 22
    },
    "textPosition" : {
      "x" : 156,
      "y" : 599
    },
    "connectors" : [ {
      "edgeId" : 96272,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 232,
          "y" : 608
        },
        "to" : {
          "x" : 263,
          "y" : 607
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96277,
    "reactomeId" : 11044746,
    "displayName" : "FNTA:FNTB",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 227,
      "y" : 552
    },
    "minX" : 186,
    "maxX" : 306,
    "minY" : 519,
    "maxY" : 605,
    "prop" : {
      "x" : 186,
      "y" : 537,
      "width" : 82,
      "height" : 30
    },
    "textPosition" : {
      "x" : 190,
      "y" : 546
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 268,
          "y" : 537
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 268,
          "y" : 537
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96272,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 250,
          "y" : 570
        },
        "to" : {
          "x" : 298,
          "y" : 599
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 302,
          "y" : 601
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 302,
          "y" : 601
        }
      }
    }, {
      "edgeId" : 96279,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 225,
          "y" : 534
        },
        "to" : {
          "x" : 223,
          "y" : 519
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96276,
    "reactomeId" : 11044739,
    "displayName" : "S-Farn-proRAS",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 488,
      "y" : 645
    },
    "minX" : 354,
    "maxX" : 534,
    "minY" : 606,
    "maxY" : 664,
    "prop" : {
      "x" : 443,
      "y" : 626,
      "width" : 91,
      "height" : 38
    },
    "textPosition" : {
      "x" : 462,
      "y" : 627
    },
    "connectors" : [ {
      "edgeId" : 96272,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 437,
          "y" : 631
        },
        "to" : {
          "x" : 354,
          "y" : 606
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 429,
          "y" : 633
        },
        "b" : {
          "x" : 437,
          "y" : 631
        },
        "c" : {
          "x" : 432,
          "y" : 625
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 432,
          "y" : 625
        }
      }
    } ]
  }, {
    "id" : 96278,
    "reactomeId" : 11044749,
    "displayName" : "FNTA:FNTB:FTase inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 319,
      "y" : 489
    },
    "minX" : 258,
    "maxX" : 387,
    "minY" : 465,
    "maxY" : 598,
    "prop" : {
      "x" : 258,
      "y" : 471,
      "width" : 123,
      "height" : 37
    },
    "textPosition" : {
      "x" : 260,
      "y" : 473
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 381,
          "y" : 471
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 381,
          "y" : 471
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96272,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 317,
          "y" : 511
        },
        "to" : {
          "x" : 312,
          "y" : 598
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 308,
          "y" : 598
        },
        "b" : {
          "x" : 316,
          "y" : 598
        },
        "c" : {
          "x" : 312,
          "y" : 598
        },
        "type" : "STOP",
        "centre" : {
          "x" : 312,
          "y" : 598
        }
      }
    }, {
      "edgeId" : 96279,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96280,
    "reactomeId" : 9653479,
    "displayName" : "FNTB inhibitors",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 122,
      "y" : 499
    },
    "minX" : 60,
    "maxX" : 223,
    "minY" : 485,
    "maxY" : 519,
    "prop" : {
      "x" : 60,
      "y" : 485,
      "width" : 124,
      "height" : 28
    },
    "textPosition" : {
      "x" : 71,
      "y" : 488
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 96279,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 190,
          "y" : 511
        },
        "to" : {
          "x" : 223,
          "y" : 519
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96283,
    "reactomeId" : 71284,
    "displayName" : "AdoMet",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 432,
      "y" : 494
    },
    "minX" : 402,
    "maxX" : 492,
    "minY" : 478,
    "maxY" : 509,
    "prop" : {
      "x" : 402,
      "y" : 479,
      "width" : 61,
      "height" : 30
    },
    "textPosition" : {
      "x" : 405,
      "y" : 483
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 458,
          "y" : 484
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 458,
          "y" : 484
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96281,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 466,
          "y" : 495
        },
        "to" : {
          "x" : 492,
          "y" : 497
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96282,
    "reactomeId" : 11044498,
    "displayName" : "S-Farn-RAS",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 495,
      "y" : 548
    },
    "minX" : 449,
    "maxX" : 541,
    "minY" : 497,
    "maxY" : 561,
    "prop" : {
      "x" : 449,
      "y" : 535,
      "width" : 92,
      "height" : 26
    },
    "textPosition" : {
      "x" : 457,
      "y" : 537
    },
    "connectors" : [ {
      "edgeId" : 96281,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 494,
          "y" : 529
        },
        "to" : {
          "x" : 492,
          "y" : 497
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96285,
    "reactomeId" : 11044566,
    "displayName" : "S-Farn-Me RAS",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 525,
      "y" : 402
    },
    "minX" : 475,
    "maxX" : 576,
    "minY" : 386,
    "maxY" : 450,
    "prop" : {
      "x" : 475,
      "y" : 386,
      "width" : 101,
      "height" : 32
    },
    "textPosition" : {
      "x" : 476,
      "y" : 391
    },
    "connectors" : [ {
      "edgeId" : 96281,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 515,
          "y" : 424
        },
        "to" : {
          "x" : 496,
          "y" : 450
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 514,
          "y" : 432
        },
        "b" : {
          "x" : 515,
          "y" : 424
        },
        "c" : {
          "x" : 508,
          "y" : 427
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 508,
          "y" : 427
        }
      }
    } ]
  }, {
    "id" : 96284,
    "reactomeId" : 71285,
    "displayName" : "AdoHcy",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 421,
      "y" : 422
    },
    "minX" : 391,
    "maxX" : 496,
    "minY" : 406,
    "maxY" : 450,
    "prop" : {
      "x" : 391,
      "y" : 407,
      "width" : 61,
      "height" : 30
    },
    "textPosition" : {
      "x" : 394,
      "y" : 411
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 447,
          "y" : 412
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 447,
          "y" : 412
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96281,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 455,
          "y" : 433
        },
        "to" : {
          "x" : 496,
          "y" : 450
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 463,
          "y" : 432
        },
        "b" : {
          "x" : 455,
          "y" : 433
        },
        "c" : {
          "x" : 460,
          "y" : 439
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 460,
          "y" : 439
        }
      }
    } ]
  }, {
    "id" : 96287,
    "reactomeId" : 11044568,
    "displayName" : "ICMT:Zn2+:Cysmethynil",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 840,
      "y" : 582
    },
    "minX" : 501,
    "maxX" : 895,
    "minY" : 474,
    "maxY" : 602,
    "prop" : {
      "x" : 791,
      "y" : 562,
      "width" : 98,
      "height" : 40
    },
    "textPosition" : {
      "x" : 799,
      "y" : 567
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 889,
          "y" : 562
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 889,
          "y" : 562
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96281,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 788,
          "y" : 566
        },
        "to" : {
          "x" : 502,
          "y" : 478
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 501,
          "y" : 482
        },
        "b" : {
          "x" : 503,
          "y" : 474
        },
        "c" : {
          "x" : 502,
          "y" : 478
        },
        "type" : "STOP",
        "centre" : {
          "x" : 502,
          "y" : 478
        }
      }
    } ]
  }, {
    "id" : 96286,
    "reactomeId" : 11031272,
    "displayName" : "ICMT:Zn2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 823,
      "y" : 472
    },
    "minX" : 501,
    "maxX" : 866,
    "minY" : 455,
    "maxY" : 483,
    "prop" : {
      "x" : 786,
      "y" : 461,
      "width" : 74,
      "height" : 22
    },
    "textPosition" : {
      "x" : 801,
      "y" : 448
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 860,
          "y" : 461
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 860,
          "y" : 461
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96281,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 783,
          "y" : 472
        },
        "to" : {
          "x" : 509,
          "y" : 475
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 505,
          "y" : 475
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 505,
          "y" : 475
        }
      }
    } ]
  }, {
    "id" : 96289,
    "reactomeId" : 11044830,
    "displayName" : "S-Farn Me KRAS4A, HRAS, NRAS",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 677,
      "y" : 395
    },
    "minX" : 615,
    "maxX" : 740,
    "minY" : 315,
    "maxY" : 413,
    "prop" : {
      "x" : 615,
      "y" : 377,
      "width" : 125,
      "height" : 36
    },
    "textPosition" : {
      "x" : 613,
      "y" : 377
    },
    "connectors" : [ {
      "edgeId" : 96288,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 674,
          "y" : 371
        },
        "to" : {
          "x" : 665,
          "y" : 315
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96291,
    "reactomeId" : 11044824,
    "displayName" : "S-Farn-Me PalmS KRAS4A,HRAS, NRAS",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 616,
      "y" : 190
    },
    "minX" : 557,
    "maxX" : 676,
    "minY" : 161,
    "maxY" : 261,
    "prop" : {
      "x" : 557,
      "y" : 161,
      "width" : 119,
      "height" : 59
    },
    "textPosition" : {
      "x" : 558,
      "y" : 166
    },
    "connectors" : [ {
      "edgeId" : 96288,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 634,
          "y" : 226
        },
        "to" : {
          "x" : 660,
          "y" : 261
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 641,
          "y" : 229
        },
        "b" : {
          "x" : 634,
          "y" : 226
        },
        "c" : {
          "x" : 635,
          "y" : 234
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 635,
          "y" : 234
        }
      }
    }, {
      "edgeId" : 96294,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96290,
    "reactomeId" : 200993,
    "displayName" : "PALM-CoA",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 602,
      "y" : 334
    },
    "minX" : 563,
    "maxX" : 665,
    "minY" : 315,
    "maxY" : 349,
    "prop" : {
      "x" : 563,
      "y" : 319,
      "width" : 78,
      "height" : 30
    },
    "textPosition" : {
      "x" : 568,
      "y" : 323
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 636,
          "y" : 324
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 636,
          "y" : 324
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96288,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 644,
          "y" : 322
        },
        "to" : {
          "x" : 665,
          "y" : 315
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96293,
    "reactomeId" : 11044846,
    "displayName" : "ZDHHC9:GOLGA7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 754,
      "y" : 320
    },
    "minX" : 671,
    "maxX" : 816,
    "minY" : 279,
    "maxY" : 331,
    "prop" : {
      "x" : 698,
      "y" : 309,
      "width" : 112,
      "height" : 22
    },
    "textPosition" : {
      "x" : 722,
      "y" : 296
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 810,
          "y" : 309
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 810,
          "y" : 309
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96288,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 744,
          "y" : 306
        },
        "to" : {
          "x" : 718,
          "y" : 279
        }
      }, {
        "from" : {
          "x" : 718,
          "y" : 279
        },
        "to" : {
          "x" : 679,
          "y" : 288
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 675,
          "y" : 288
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 675,
          "y" : 288
        }
      }
    } ]
  }, {
    "id" : 96292,
    "reactomeId" : 76194,
    "displayName" : "CoA-SH",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 593,
      "y" : 257
    },
    "minX" : 563,
    "maxX" : 660,
    "minY" : 241,
    "maxY" : 272,
    "prop" : {
      "x" : 563,
      "y" : 242,
      "width" : 61,
      "height" : 30
    },
    "textPosition" : {
      "x" : 567,
      "y" : 246
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 619,
          "y" : 247
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 619,
          "y" : 247
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96288,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 627,
          "y" : 258
        },
        "to" : {
          "x" : 660,
          "y" : 261
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 634,
          "y" : 255
        },
        "b" : {
          "x" : 627,
          "y" : 258
        },
        "c" : {
          "x" : 634,
          "y" : 263
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 634,
          "y" : 263
        }
      }
    } ]
  }, {
    "id" : 96295,
    "reactomeId" : 11044826,
    "displayName" : "S-Farn-Me-PalmS KRAS4A, HRAS, NRAS",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 584,
      "y" : 53
    },
    "minX" : 479,
    "maxX" : 639,
    "minY" : 23,
    "maxY" : 78,
    "prop" : {
      "x" : 530,
      "y" : 28,
      "width" : 109,
      "height" : 50
    },
    "textPosition" : {
      "x" : 532,
      "y" : 28
    },
    "connectors" : [ {
      "edgeId" : 96294,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 96296,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 524,
          "y" : 37
        },
        "to" : {
          "x" : 479,
          "y" : 23
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96297,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 515,
      "y" : 105
    },
    "minX" : 479,
    "maxX" : 538,
    "minY" : 23,
    "maxY" : 120,
    "prop" : {
      "x" : 494,
      "y" : 90,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 498,
      "y" : 94
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 532,
          "y" : 95
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 532,
          "y" : 95
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96296,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 508,
          "y" : 87
        },
        "to" : {
          "x" : 479,
          "y" : 23
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 96299,
    "reactomeId" : 8848337,
    "displayName" : "PALM(-)",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 200,
      "y" : 106
    },
    "minX" : 169,
    "maxX" : 267,
    "minY" : 30,
    "maxY" : 121,
    "prop" : {
      "x" : 169,
      "y" : 91,
      "width" : 63,
      "height" : 30
    },
    "textPosition" : {
      "x" : 173,
      "y" : 95
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 227,
          "y" : 96
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 227,
          "y" : 96
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96296,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 213,
          "y" : 88
        },
        "to" : {
          "x" : 267,
          "y" : 30
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 215,
          "y" : 80
        },
        "b" : {
          "x" : 213,
          "y" : 88
        },
        "c" : {
          "x" : 221,
          "y" : 86
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 221,
          "y" : 86
        }
      }
    } ]
  }, {
    "id" : 96298,
    "reactomeId" : 11044907,
    "displayName" : "S-Farn-Me KRAS4A, HRAS, NRAS",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 153,
      "y" : 39
    },
    "minX" : 89,
    "maxX" : 267,
    "minY" : 21,
    "maxY" : 57,
    "prop" : {
      "x" : 89,
      "y" : 21,
      "width" : 129,
      "height" : 36
    },
    "textPosition" : {
      "x" : 89,
      "y" : 21
    },
    "connectors" : [ {
      "edgeId" : 96296,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 224,
          "y" : 33
        },
        "to" : {
          "x" : 267,
          "y" : 30
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 231,
          "y" : 29
        },
        "b" : {
          "x" : 224,
          "y" : 33
        },
        "c" : {
          "x" : 231,
          "y" : 37
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 231,
          "y" : 37
        }
      }
    } ]
  }, {
    "id" : 96301,
    "reactomeId" : 11044869,
    "displayName" : "Palmostatin B:LYPLA1 dimer, ABHD17A,B,C",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 178,
      "y" : 179
    },
    "minX" : 130,
    "maxX" : 406,
    "minY" : 28,
    "maxY" : 204,
    "prop" : {
      "x" : 130,
      "y" : 154,
      "width" : 97,
      "height" : 50
    },
    "textPosition" : {
      "x" : 133,
      "y" : 141
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 227,
          "y" : 154
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 227,
          "y" : 154
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96309,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 96296,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 216,
          "y" : 151
        },
        "to" : {
          "x" : 404,
          "y" : 31
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 402,
          "y" : 28
        },
        "b" : {
          "x" : 406,
          "y" : 34
        },
        "c" : {
          "x" : 404,
          "y" : 31
        },
        "type" : "STOP",
        "centre" : {
          "x" : 404,
          "y" : 31
        }
      }
    } ]
  }, {
    "id" : 96300,
    "reactomeId" : 11044867,
    "displayName" : "LYPLA1 dimer, ABHD17A,B,C",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 422,
      "y" : 77
    },
    "minX" : 370,
    "maxX" : 471,
    "minY" : 34,
    "maxY" : 203,
    "prop" : {
      "x" : 374,
      "y" : 59,
      "width" : 97,
      "height" : 36
    },
    "textPosition" : {
      "x" : 374,
      "y" : 59
    },
    "connectors" : [ {
      "edgeId" : 96309,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 414,
          "y" : 101
        },
        "to" : {
          "x" : 370,
          "y" : 203
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 96296,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 418,
          "y" : 53
        },
        "to" : {
          "x" : 415,
          "y" : 42
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 415,
          "y" : 38
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 415,
          "y" : 38
        }
      }
    } ]
  }, {
    "id" : 96303,
    "reactomeId" : 11044564,
    "displayName" : "Homologues of S-Farn-Me KRAS4B",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 817,
      "y" : 413
    },
    "minX" : 771,
    "maxX" : 864,
    "minY" : 393,
    "maxY" : 433,
    "prop" : {
      "x" : 771,
      "y" : 393,
      "width" : 93,
      "height" : 40
    },
    "textPosition" : {
      "x" : 772,
      "y" : 389
    },
    "connectors" : [ {
      "edgeId" : 96302,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96304,
    "reactomeId" : 11004468,
    "displayName" : "Homologues of S-Farn-Me KRAS4B",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1037,
      "y" : 43
    },
    "minX" : 976,
    "maxX" : 1119,
    "minY" : 27,
    "maxY" : 60,
    "prop" : {
      "x" : 976,
      "y" : 27,
      "width" : 123,
      "height" : 33
    },
    "textPosition" : {
      "x" : 978,
      "y" : 26
    },
    "connectors" : [ {
      "edgeId" : 96311,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1102,
          "y" : 43
        },
        "to" : {
          "x" : 1119,
          "y" : 44
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 96302,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96307,
    "reactomeId" : 29420,
    "displayName" : "GDP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 718,
      "y" : 104
    },
    "minX" : 697,
    "maxX" : 772,
    "minY" : 87,
    "maxY" : 119,
    "prop" : {
      "x" : 697,
      "y" : 89,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 701,
      "y" : 93
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 734,
          "y" : 94
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 734,
          "y" : 94
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96305,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 742,
          "y" : 97
        },
        "to" : {
          "x" : 772,
          "y" : 87
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96306,
    "reactomeId" : 11004470,
    "displayName" : "mature p21 RAS",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 726,
      "y" : 52
    },
    "minX" : 674,
    "maxX" : 778,
    "minY" : 41,
    "maxY" : 87,
    "prop" : {
      "x" : 674,
      "y" : 41,
      "width" : 104,
      "height" : 22
    },
    "textPosition" : {
      "x" : 683,
      "y" : 35
    },
    "connectors" : [ {
      "edgeId" : 96305,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 740,
          "y" : 69
        },
        "to" : {
          "x" : 772,
          "y" : 87
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96308,
    "reactomeId" : 11004996,
    "displayName" : "p21 RAS:GDP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 898,
      "y" : 72
    },
    "minX" : 852,
    "maxX" : 951,
    "minY" : 45,
    "maxY" : 93,
    "prop" : {
      "x" : 852,
      "y" : 51,
      "width" : 93,
      "height" : 42
    },
    "textPosition" : {
      "x" : 853,
      "y" : 72
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 945,
          "y" : 51
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 945,
          "y" : 51
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96305,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96310,
    "reactomeId" : 9647934,
    "displayName" : "Palmostatin B",
    "schemaClass" : "ChemicalDrug",
    "renderableClass" : "ChemicalDrug",
    "position" : {
      "x" : 404,
      "y" : 253
    },
    "minX" : 352,
    "maxX" : 457,
    "minY" : 203,
    "maxY" : 280,
    "prop" : {
      "x" : 352,
      "y" : 227,
      "width" : 105,
      "height" : 53
    },
    "textPosition" : {
      "x" : 357,
      "y" : 243
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 255,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 96309,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 385,
          "y" : 224
        },
        "to" : {
          "x" : 370,
          "y" : 203
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96313,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1184,
      "y" : 105
    },
    "minX" : 1161,
    "maxX" : 1206,
    "minY" : 43,
    "maxY" : 120,
    "prop" : {
      "x" : 1164,
      "y" : 90,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1168,
      "y" : 94
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1200,
          "y" : 95
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1200,
          "y" : 95
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96311,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1178,
          "y" : 87
        },
        "to" : {
          "x" : 1161,
          "y" : 43
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1172,
          "y" : 82
        },
        "b" : {
          "x" : 1178,
          "y" : 87
        },
        "c" : {
          "x" : 1179,
          "y" : 79
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1179,
          "y" : 79
        }
      }
    } ]
  }, {
    "id" : 96312,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1101,
      "y" : 92
    },
    "minX" : 1081,
    "maxX" : 1122,
    "minY" : 44,
    "maxY" : 107,
    "prop" : {
      "x" : 1081,
      "y" : 77,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1085,
      "y" : 81
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1116,
          "y" : 82
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1116,
          "y" : 82
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96311,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1106,
          "y" : 74
        },
        "to" : {
          "x" : 1119,
          "y" : 44
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96315,
    "reactomeId" : 11020337,
    "displayName" : "p-5Y-PKC-theta:DAG",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1147,
      "y" : 164
    },
    "minX" : 1106,
    "maxX" : 1194,
    "minY" : 52,
    "maxY" : 180,
    "prop" : {
      "x" : 1106,
      "y" : 148,
      "width" : 82,
      "height" : 32
    },
    "textPosition" : {
      "x" : 1111,
      "y" : 147
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1188,
          "y" : 148
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1188,
          "y" : 148
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 96311,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1146,
          "y" : 142
        },
        "to" : {
          "x" : 1143,
          "y" : 60
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1143,
          "y" : 56
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1143,
          "y" : 56
        }
      }
    } ]
  }, {
    "id" : 96314,
    "reactomeId" : 11044973,
    "displayName" : "Homologues of pS181-S-Farn-Me KRAS4B",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1257,
      "y" : 46
    },
    "minX" : 1161,
    "maxX" : 1311,
    "minY" : 24,
    "maxY" : 69,
    "prop" : {
      "x" : 1203,
      "y" : 24,
      "width" : 108,
      "height" : 45
    },
    "textPosition" : {
      "x" : 1204,
      "y" : 22
    },
    "connectors" : [ {
      "edgeId" : 96311,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1200,
          "y" : 44
        },
        "to" : {
          "x" : 1161,
          "y" : 43
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1193,
          "y" : 48
        },
        "b" : {
          "x" : 1200,
          "y" : 44
        },
        "c" : {
          "x" : 1193,
          "y" : 40
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1193,
          "y" : 40
        }
      }
    }, {
      "edgeId" : 96316,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 96317,
    "reactomeId" : 11045008,
    "displayName" : "Homologues of pS181-S-Farn-Me KRAS4B",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1156,
      "y" : 235
    },
    "minX" : 1096,
    "maxX" : 1216,
    "minY" : 217,
    "maxY" : 253,
    "prop" : {
      "x" : 1096,
      "y" : 217,
      "width" : 120,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1097,
      "y" : 211
    },
    "connectors" : [ {
      "edgeId" : 96316,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 96305,
    "reactomeId" : 11044915,
    "displayName" : "mature p21 RAS binds GDP",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 816,
      "y" : 84
    },
    "minX" : 772,
    "maxX" : 849,
    "minY" : 78,
    "maxY" : 90,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 772,
        "y" : 87
      },
      "to" : {
        "x" : 816,
        "y" : 84
      }
    }, {
      "from" : {
        "x" : 816,
        "y" : 84
      },
      "to" : {
        "x" : 849,
        "y" : 78
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 843,
        "y" : 83
      },
      "b" : {
        "x" : 849,
        "y" : 78
      },
      "c" : {
        "x" : 841,
        "y" : 75
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 841,
        "y" : 75
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 816,
        "y" : 84
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 816,
        "y" : 84
      }
    },
    "inputs" : [ {
      "id" : 96306,
      "points" : [ {
        "x" : 740,
        "y" : 69
      } ]
    }, {
      "id" : 96307,
      "points" : [ {
        "x" : 742,
        "y" : 97
      } ]
    } ],
    "outputs" : [ {
      "id" : 96308
    } ]
  }, {
    "id" : 96272,
    "reactomeId" : 11044751,
    "displayName" : "pro-RAS proteins are farnesylated",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 312,
      "y" : 607
    },
    "minX" : 263,
    "maxX" : 354,
    "minY" : 601,
    "maxY" : 613,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 263,
        "y" : 607
      },
      "to" : {
        "x" : 312,
        "y" : 607
      }
    }, {
      "from" : {
        "x" : 312,
        "y" : 607
      },
      "to" : {
        "x" : 354,
        "y" : 606
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 306,
        "y" : 601
      },
      "b" : {
        "x" : 318,
        "y" : 613
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 312,
        "y" : 607
      }
    },
    "inputs" : [ {
      "id" : 96273,
      "points" : [ {
        "x" : 242,
        "y" : 636
      } ]
    }, {
      "id" : 96274,
      "points" : [ {
        "x" : 232,
        "y" : 608
      } ]
    } ],
    "outputs" : [ {
      "id" : 96275,
      "points" : [ {
        "x" : 354,
        "y" : 646
      } ]
    }, {
      "id" : 96276,
      "points" : [ {
        "x" : 437,
        "y" : 631
      } ]
    } ],
    "catalysts" : [ {
      "id" : 96277,
      "points" : [ {
        "x" : 250,
        "y" : 570
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 96278,
      "points" : [ {
        "x" : 317,
        "y" : 511
      } ]
    } ]
  }, {
    "id" : 96288,
    "reactomeId" : 11044849,
    "displayName" : "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 663,
      "y" : 291
    },
    "minX" : 657,
    "maxX" : 669,
    "minY" : 261,
    "maxY" : 315,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 665,
        "y" : 315
      },
      "to" : {
        "x" : 663,
        "y" : 291
      }
    }, {
      "from" : {
        "x" : 663,
        "y" : 291
      },
      "to" : {
        "x" : 660,
        "y" : 261
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 657,
        "y" : 285
      },
      "b" : {
        "x" : 669,
        "y" : 297
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 663,
        "y" : 291
      }
    },
    "inputs" : [ {
      "id" : 96289,
      "points" : [ {
        "x" : 674,
        "y" : 371
      } ]
    }, {
      "id" : 96290,
      "points" : [ {
        "x" : 644,
        "y" : 322
      } ]
    } ],
    "outputs" : [ {
      "id" : 96291,
      "points" : [ {
        "x" : 634,
        "y" : 226
      } ]
    }, {
      "id" : 96292,
      "points" : [ {
        "x" : 627,
        "y" : 258
      } ]
    } ],
    "catalysts" : [ {
      "id" : 96293,
      "points" : [ {
        "x" : 744,
        "y" : 306
      }, {
        "x" : 718,
        "y" : 279
      } ]
    } ]
  }, {
    "id" : 96309,
    "reactomeId" : 11044871,
    "displayName" : "Palmostatin B binds RAS depalmitoylases",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 318,
      "y" : 190
    },
    "minX" : 230,
    "maxX" : 370,
    "minY" : 182,
    "maxY" : 203,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 370,
        "y" : 203
      },
      "to" : {
        "x" : 318,
        "y" : 190
      }
    }, {
      "from" : {
        "x" : 318,
        "y" : 190
      },
      "to" : {
        "x" : 230,
        "y" : 182
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 237,
        "y" : 179
      },
      "b" : {
        "x" : 230,
        "y" : 182
      },
      "c" : {
        "x" : 237,
        "y" : 187
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 237,
        "y" : 187
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 318,
        "y" : 190
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 318,
        "y" : 190
      }
    },
    "inputs" : [ {
      "id" : 96300,
      "points" : [ {
        "x" : 414,
        "y" : 101
      } ]
    }, {
      "id" : 96310,
      "points" : [ {
        "x" : 385,
        "y" : 224
      } ]
    } ],
    "outputs" : [ {
      "id" : 96301
    } ]
  }, {
    "id" : 96311,
    "reactomeId" : 11044976,
    "displayName" : "KRAS4B is phosphorylated on serine 181",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1143,
      "y" : 44
    },
    "minX" : 1119,
    "maxX" : 1161,
    "minY" : 38,
    "maxY" : 50,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1119,
        "y" : 44
      },
      "to" : {
        "x" : 1143,
        "y" : 44
      }
    }, {
      "from" : {
        "x" : 1143,
        "y" : 44
      },
      "to" : {
        "x" : 1161,
        "y" : 43
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1137,
        "y" : 38
      },
      "b" : {
        "x" : 1149,
        "y" : 50
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1143,
        "y" : 44
      }
    },
    "inputs" : [ {
      "id" : 96312,
      "points" : [ {
        "x" : 1106,
        "y" : 74
      } ]
    }, {
      "id" : 96304,
      "points" : [ {
        "x" : 1102,
        "y" : 43
      } ]
    } ],
    "outputs" : [ {
      "id" : 96313,
      "points" : [ {
        "x" : 1178,
        "y" : 87
      } ]
    }, {
      "id" : 96314,
      "points" : [ {
        "x" : 1200,
        "y" : 44
      } ]
    } ],
    "catalysts" : [ {
      "id" : 96315,
      "points" : [ {
        "x" : 1146,
        "y" : 142
      } ]
    } ]
  }, {
    "id" : 96279,
    "reactomeId" : 11044851,
    "displayName" : "FNTB inhibitors bind FNTA:FNTB",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 230,
      "y" : 487
    },
    "minX" : 223,
    "maxX" : 255,
    "minY" : 481,
    "maxY" : 519,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 223,
        "y" : 519
      },
      "to" : {
        "x" : 230,
        "y" : 487
      }
    }, {
      "from" : {
        "x" : 230,
        "y" : 487
      },
      "to" : {
        "x" : 255,
        "y" : 487
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 248,
        "y" : 491
      },
      "b" : {
        "x" : 255,
        "y" : 487
      },
      "c" : {
        "x" : 248,
        "y" : 483
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 248,
        "y" : 483
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 230,
        "y" : 487
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 230,
        "y" : 487
      }
    },
    "inputs" : [ {
      "id" : 96277,
      "points" : [ {
        "x" : 225,
        "y" : 534
      } ]
    }, {
      "id" : 96280,
      "points" : [ {
        "x" : 190,
        "y" : 511
      } ]
    } ],
    "outputs" : [ {
      "id" : 96278
    } ]
  }, {
    "id" : 96294,
    "reactomeId" : 11044828,
    "displayName" : "mature RAS proteins translocate to plasma membrane",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 593,
      "y" : 115
    },
    "minX" : 587,
    "maxX" : 606,
    "minY" : 84,
    "maxY" : 155,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 606,
        "y" : 155
      },
      "to" : {
        "x" : 593,
        "y" : 115
      }
    }, {
      "from" : {
        "x" : 593,
        "y" : 115
      },
      "to" : {
        "x" : 587,
        "y" : 84
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 592,
        "y" : 90
      },
      "b" : {
        "x" : 587,
        "y" : 84
      },
      "c" : {
        "x" : 584,
        "y" : 92
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 584,
        "y" : 92
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 587,
        "y" : 109
      },
      "b" : {
        "x" : 599,
        "y" : 121
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 593,
        "y" : 115
      }
    },
    "inputs" : [ {
      "id" : 96291
    } ],
    "outputs" : [ {
      "id" : 96295
    } ]
  }, {
    "id" : 96281,
    "reactomeId" : 11044570,
    "displayName" : "ICMT methylates S-Farn RAS proteins",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 493,
      "y" : 475
    },
    "minX" : 487,
    "maxX" : 499,
    "minY" : 450,
    "maxY" : 497,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 492,
        "y" : 497
      },
      "to" : {
        "x" : 493,
        "y" : 475
      }
    }, {
      "from" : {
        "x" : 493,
        "y" : 475
      },
      "to" : {
        "x" : 496,
        "y" : 450
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 487,
        "y" : 469
      },
      "b" : {
        "x" : 499,
        "y" : 481
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 493,
        "y" : 475
      }
    },
    "inputs" : [ {
      "id" : 96282,
      "points" : [ {
        "x" : 494,
        "y" : 529
      } ]
    }, {
      "id" : 96283,
      "points" : [ {
        "x" : 466,
        "y" : 495
      } ]
    } ],
    "outputs" : [ {
      "id" : 96284,
      "points" : [ {
        "x" : 455,
        "y" : 433
      } ]
    }, {
      "id" : 96285,
      "points" : [ {
        "x" : 515,
        "y" : 424
      } ]
    } ],
    "catalysts" : [ {
      "id" : 96286,
      "points" : [ {
        "x" : 783,
        "y" : 472
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 96287,
      "points" : [ {
        "x" : 788,
        "y" : 566
      } ]
    } ]
  }, {
    "id" : 96296,
    "reactomeId" : 11044910,
    "displayName" : "RAS proteins are depalmitoylated",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 412,
      "y" : 26
    },
    "minX" : 267,
    "maxX" : 479,
    "minY" : 20,
    "maxY" : 32,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 479,
        "y" : 23
      },
      "to" : {
        "x" : 412,
        "y" : 26
      }
    }, {
      "from" : {
        "x" : 412,
        "y" : 26
      },
      "to" : {
        "x" : 267,
        "y" : 30
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 406,
        "y" : 20
      },
      "b" : {
        "x" : 418,
        "y" : 32
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 412,
        "y" : 26
      }
    },
    "inputs" : [ {
      "id" : 96297,
      "points" : [ {
        "x" : 508,
        "y" : 87
      } ]
    }, {
      "id" : 96295,
      "points" : [ {
        "x" : 524,
        "y" : 37
      } ]
    } ],
    "outputs" : [ {
      "id" : 96298,
      "points" : [ {
        "x" : 224,
        "y" : 33
      } ]
    }, {
      "id" : 96299,
      "points" : [ {
        "x" : 213,
        "y" : 88
      } ]
    } ],
    "catalysts" : [ {
      "id" : 96300,
      "points" : [ {
        "x" : 418,
        "y" : 53
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 96301,
      "points" : [ {
        "x" : 216,
        "y" : 151
      } ]
    } ]
  }, {
    "id" : 96316,
    "reactomeId" : 11045010,
    "displayName" : "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1235,
      "y" : 185
    },
    "minX" : 1184,
    "maxX" : 1256,
    "minY" : 72,
    "maxY" : 214,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1256,
        "y" : 72
      },
      "to" : {
        "x" : 1253,
        "y" : 169
      }
    }, {
      "from" : {
        "x" : 1253,
        "y" : 169
      },
      "to" : {
        "x" : 1235,
        "y" : 185
      }
    }, {
      "from" : {
        "x" : 1235,
        "y" : 185
      },
      "to" : {
        "x" : 1184,
        "y" : 214
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1188,
        "y" : 207
      },
      "b" : {
        "x" : 1184,
        "y" : 214
      },
      "c" : {
        "x" : 1192,
        "y" : 214
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1192,
        "y" : 214
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1229,
        "y" : 179
      },
      "b" : {
        "x" : 1241,
        "y" : 191
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1235,
        "y" : 185
      }
    },
    "inputs" : [ {
      "id" : 96314
    } ],
    "outputs" : [ {
      "id" : 96317
    } ]
  }, {
    "id" : 96302,
    "reactomeId" : 11044913,
    "displayName" : "Mature S-Farn-Me KRAS4B translocates to plasma membrane",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 970,
      "y" : 265
    },
    "minX" : 837,
    "maxX" : 1032,
    "minY" : 63,
    "maxY" : 390,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 837,
        "y" : 390
      },
      "to" : {
        "x" : 970,
        "y" : 265
      }
    }, {
      "from" : {
        "x" : 970,
        "y" : 265
      },
      "to" : {
        "x" : 1032,
        "y" : 63
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1034,
        "y" : 71
      },
      "b" : {
        "x" : 1032,
        "y" : 63
      },
      "c" : {
        "x" : 1026,
        "y" : 68
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1026,
        "y" : 68
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 964,
        "y" : 259
      },
      "b" : {
        "x" : 976,
        "y" : 271
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 970,
        "y" : 265
      }
    },
    "inputs" : [ {
      "id" : 96303
    } ],
    "outputs" : [ {
      "id" : 96304
    } ]
  } ],
  "compartments" : [ {
    "id" : 96320,
    "reactomeId" : 17963,
    "displayName" : "Golgi lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 745,
      "y" : 254
    },
    "minX" : 655,
    "maxX" : 836,
    "minY" : 180,
    "maxY" : 329,
    "prop" : {
      "x" : 655,
      "y" : 180,
      "width" : 181,
      "height" : 149
    },
    "textPosition" : {
      "x" : 726,
      "y" : 250
    },
    "insets" : {
      "x" : 665,
      "y" : 190,
      "width" : 161,
      "height" : 129
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 96293, 96291, 96288 ]
  }, {
    "id" : 96324,
    "reactomeId" : 17906,
    "displayName" : "mitochondrial outer membrane",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1120,
      "y" : 314
    },
    "minX" : 1065,
    "maxX" : 1176,
    "minY" : 242,
    "maxY" : 386,
    "prop" : {
      "x" : 1065,
      "y" : 242,
      "width" : 111,
      "height" : 144
    },
    "textPosition" : {
      "x" : 1068,
      "y" : 271
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 96317 ]
  }, {
    "id" : 96319,
    "reactomeId" : 17957,
    "displayName" : "endoplasmic reticulum lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 664,
      "y" : 528
    },
    "minX" : 491,
    "maxX" : 837,
    "minY" : 401,
    "maxY" : 655,
    "prop" : {
      "x" : 491,
      "y" : 401,
      "width" : 346,
      "height" : 254
    },
    "textPosition" : {
      "x" : 631,
      "y" : 496
    },
    "insets" : {
      "x" : 501,
      "y" : 411,
      "width" : 326,
      "height" : 234
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 96276, 96282, 96281, 96285, 96286, 96289, 96303, 96331, 96287 ]
  }, {
    "id" : 96318,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 724,
      "y" : 416
    },
    "minX" : 0,
    "maxX" : 1448,
    "minY" : 26,
    "maxY" : 806,
    "prop" : {
      "x" : 0,
      "y" : 26,
      "width" : 1448,
      "height" : 780
    },
    "textPosition" : {
      "x" : 260,
      "y" : 200
    },
    "insets" : {
      "x" : 10,
      "y" : 36,
      "width" : 1428,
      "height" : 760
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 96272, 96273, 96274, 96275, 96277, 96279, 96278, 96319, 96283, 96284, 96290, 96292, 96320, 96294, 96295, 96297, 96298, 96299, 96300, 96301, 96296, 96305, 96306, 96307, 96280, 96304, 96330, 96309, 96310, 96312, 96313, 96311, 96315, 96324, 96314, 96332, 96302, 96316, 96308, 96329, 96334 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 96331,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 671,
      "y" : 448
    },
    "minX" : 575,
    "maxX" : 768,
    "minY" : 424,
    "maxY" : 454,
    "segments" : [ {
      "from" : {
        "x" : 768,
        "y" : 424
      },
      "to" : {
        "x" : 671,
        "y" : 448
      }
    }, {
      "from" : {
        "x" : 671,
        "y" : 448
      },
      "to" : {
        "x" : 575,
        "y" : 424
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 665,
        "y" : 442
      },
      "b" : {
        "x" : 677,
        "y" : 454
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 671,
        "y" : 448
      }
    },
    "inputs" : [ {
      "id" : 96303
    } ],
    "outputs" : [ {
      "id" : 96285
    } ]
  }, {
    "id" : 96330,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 595,
      "y" : 397
    },
    "minX" : 582,
    "maxX" : 609,
    "minY" : 391,
    "maxY" : 403,
    "segments" : [ {
      "from" : {
        "x" : 609,
        "y" : 396
      },
      "to" : {
        "x" : 582,
        "y" : 398
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 589,
        "y" : 391
      },
      "b" : {
        "x" : 601,
        "y" : 403
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 595,
        "y" : 397
      }
    },
    "inputs" : [ {
      "id" : 96289
    } ],
    "outputs" : [ {
      "id" : 96285
    } ]
  }, {
    "id" : 96333,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 886,
      "y" : 6
    },
    "minX" : 764,
    "maxX" : 973,
    "minY" : 0,
    "maxY" : 35,
    "segments" : [ {
      "from" : {
        "x" : 973,
        "y" : 27
      },
      "to" : {
        "x" : 886,
        "y" : 6
      }
    }, {
      "from" : {
        "x" : 886,
        "y" : 6
      },
      "to" : {
        "x" : 764,
        "y" : 35
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 880,
        "y" : 0
      },
      "b" : {
        "x" : 892,
        "y" : 12
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 886,
        "y" : 6
      }
    },
    "inputs" : [ {
      "id" : 96304
    } ],
    "outputs" : [ {
      "id" : 96306
    } ]
  }, {
    "id" : 96332,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 656,
      "y" : 52
    },
    "minX" : 645,
    "maxX" : 668,
    "minY" : 46,
    "maxY" : 58,
    "segments" : [ {
      "from" : {
        "x" : 668,
        "y" : 52
      },
      "to" : {
        "x" : 645,
        "y" : 52
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 650,
        "y" : 46
      },
      "b" : {
        "x" : 662,
        "y" : 58
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 656,
        "y" : 52
      }
    },
    "inputs" : [ {
      "id" : 96306
    } ],
    "outputs" : [ {
      "id" : 96295
    } ]
  }, {
    "id" : 96334,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 899,
      "y" : 108
    },
    "minX" : 893,
    "maxX" : 905,
    "minY" : 96,
    "maxY" : 121,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 898,
        "y" : 96
      },
      "to" : {
        "x" : 900,
        "y" : 121
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 895,
        "y" : 114
      },
      "b" : {
        "x" : 900,
        "y" : 121
      },
      "c" : {
        "x" : 903,
        "y" : 114
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 903,
        "y" : 114
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 893,
        "y" : 102
      },
      "b" : {
        "x" : 905,
        "y" : 114
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 899,
        "y" : 108
      }
    },
    "inputs" : [ {
      "id" : 96308
    } ],
    "outputs" : [ {
      "id" : 96329
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1448,
  "minY" : 0,
  "maxY" : 806,
  "disease" : false
}