{
  "dbId" : 11050582,
  "stableId" : "R-DDI-8854691",
  "displayName" : "Interleukin-20 family signaling",
  "nodes" : [ {
    "id" : 138579,
    "reactomeId" : 11042506,
    "displayName" : "2 x p-STAT1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2303,
      "y" : 511
    },
    "minX" : 2252,
    "maxX" : 2360,
    "minY" : 495,
    "maxY" : 522,
    "prop" : {
      "x" : 2252,
      "y" : 501,
      "width" : 102,
      "height" : 21
    },
    "textPosition" : {
      "x" : 2263,
      "y" : 501
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2354,
          "y" : 501
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2354,
          "y" : 501
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138578,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138577,
    "reactomeId" : 11042482,
    "displayName" : "2xp-STAT3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2407,
      "y" : 471
    },
    "minX" : 2359,
    "maxX" : 2462,
    "minY" : 454,
    "maxY" : 482,
    "prop" : {
      "x" : 2359,
      "y" : 460,
      "width" : 97,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2371,
      "y" : 461
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2456,
          "y" : 460
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2456,
          "y" : 460
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138576,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138566,
    "reactomeId" : 11015489,
    "displayName" : "Homologues of p-Y705-STAT3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 489,
      "y" : 261
    },
    "minX" : 436,
    "maxX" : 542,
    "minY" : 252,
    "maxY" : 300,
    "prop" : {
      "x" : 436,
      "y" : 252,
      "width" : 106,
      "height" : 18
    },
    "textPosition" : {
      "x" : 436,
      "y" : 244
    },
    "connectors" : [ {
      "edgeId" : 138565,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 481,
            "y" : 288
          },
          "b" : {
            "x" : 493,
            "y" : 300
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 487,
            "y" : 294
          }
        }
      }
    } ]
  }, {
    "id" : 138567,
    "reactomeId" : 11015493,
    "displayName" : "p-Y705-STAT3 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 491,
      "y" : 359
    },
    "minX" : 422,
    "maxX" : 566,
    "minY" : 340,
    "maxY" : 372,
    "prop" : {
      "x" : 422,
      "y" : 346,
      "width" : 138,
      "height" : 26
    },
    "textPosition" : {
      "x" : 425,
      "y" : 351
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 560,
          "y" : 346
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 560,
          "y" : 346
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138565,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 138568,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138571,
    "reactomeId" : 11042462,
    "displayName" : "Homologues of p-STAT3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2406,
      "y" : 227
    },
    "minX" : 2366,
    "maxX" : 2447,
    "minY" : 217,
    "maxY" : 263,
    "prop" : {
      "x" : 2366,
      "y" : 217,
      "width" : 81,
      "height" : 20
    },
    "textPosition" : {
      "x" : 2367,
      "y" : 203
    },
    "connectors" : [ {
      "edgeId" : 138570,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2400,
            "y" : 251
          },
          "b" : {
            "x" : 2412,
            "y" : 263
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2406,
            "y" : 257
          }
        }
      }
    } ]
  }, {
    "id" : 138569,
    "reactomeId" : 11015537,
    "displayName" : "p-Y705-STAT3 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 492,
      "y" : 469
    },
    "minX" : 425,
    "maxX" : 565,
    "minY" : 447,
    "maxY" : 485,
    "prop" : {
      "x" : 425,
      "y" : 453,
      "width" : 134,
      "height" : 32
    },
    "textPosition" : {
      "x" : 426,
      "y" : 464
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 559,
          "y" : 453
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 559,
          "y" : 453
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138568,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138574,
    "reactomeId" : 11041467,
    "displayName" : "Homologues of p-STAT1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2297,
      "y" : 255
    },
    "minX" : 2266,
    "maxX" : 2328,
    "minY" : 244,
    "maxY" : 294,
    "prop" : {
      "x" : 2266,
      "y" : 244,
      "width" : 62,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2267,
      "y" : 231
    },
    "connectors" : [ {
      "edgeId" : 138573,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2290,
            "y" : 282
          },
          "b" : {
            "x" : 2302,
            "y" : 294
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2296,
            "y" : 288
          }
        }
      }
    } ]
  }, {
    "id" : 138575,
    "reactomeId" : 11042444,
    "displayName" : "2 x p-STAT1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2301,
      "y" : 339
    },
    "minX" : 2254,
    "maxX" : 2354,
    "minY" : 322,
    "maxY" : 351,
    "prop" : {
      "x" : 2254,
      "y" : 328,
      "width" : 94,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2261,
      "y" : 330
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2348,
          "y" : 328
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2348,
          "y" : 328
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138578,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 138573,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138572,
    "reactomeId" : 11042464,
    "displayName" : "2 x p-STAT3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2407,
      "y" : 319
    },
    "minX" : 2358,
    "maxX" : 2462,
    "minY" : 304,
    "maxY" : 329,
    "prop" : {
      "x" : 2358,
      "y" : 310,
      "width" : 98,
      "height" : 19
    },
    "textPosition" : {
      "x" : 2367,
      "y" : 308
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2456,
          "y" : 310
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2456,
          "y" : 310
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138576,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 138570,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 138578,
    "reactomeId" : 11042508,
    "displayName" : "p-STAT1 dimer translocates from the cytosol to the nucleoplasm",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2303,
      "y" : 448
    },
    "minX" : 2297,
    "maxX" : 2309,
    "minY" : 354,
    "maxY" : 498,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 2301,
        "y" : 354
      },
      "to" : {
        "x" : 2303,
        "y" : 448
      }
    }, {
      "from" : {
        "x" : 2303,
        "y" : 448
      },
      "to" : {
        "x" : 2303,
        "y" : 498
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2299,
        "y" : 491
      },
      "b" : {
        "x" : 2303,
        "y" : 498
      },
      "c" : {
        "x" : 2307,
        "y" : 491
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2307,
        "y" : 491
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2297,
        "y" : 442
      },
      "b" : {
        "x" : 2309,
        "y" : 454
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2303,
        "y" : 448
      }
    },
    "inputs" : [ {
      "id" : 138575
    } ],
    "outputs" : [ {
      "id" : 138579
    } ]
  }, {
    "id" : 138576,
    "reactomeId" : 11042484,
    "displayName" : "p-STAT3 dimer translocates from cytosol to nucleoplasm",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2406,
      "y" : 355
    },
    "minX" : 2400,
    "maxX" : 2412,
    "minY" : 332,
    "maxY" : 457,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 2406,
        "y" : 332
      },
      "to" : {
        "x" : 2406,
        "y" : 355
      }
    }, {
      "from" : {
        "x" : 2406,
        "y" : 355
      },
      "to" : {
        "x" : 2406,
        "y" : 457
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2402,
        "y" : 450
      },
      "b" : {
        "x" : 2406,
        "y" : 457
      },
      "c" : {
        "x" : 2410,
        "y" : 450
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2410,
        "y" : 450
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2400,
        "y" : 349
      },
      "b" : {
        "x" : 2412,
        "y" : 361
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2406,
        "y" : 355
      }
    },
    "inputs" : [ {
      "id" : 138572
    } ],
    "outputs" : [ {
      "id" : 138577
    } ]
  }, {
    "id" : 138565,
    "reactomeId" : 11031022,
    "displayName" : "p-Y705-STAT3 dimerizes",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 487,
      "y" : 316
    },
    "minX" : 481,
    "maxX" : 493,
    "minY" : 273,
    "maxY" : 343,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 488,
        "y" : 273
      },
      "to" : {
        "x" : 487,
        "y" : 316
      }
    }, {
      "from" : {
        "x" : 487,
        "y" : 316
      },
      "to" : {
        "x" : 489,
        "y" : 343
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 484,
        "y" : 336
      },
      "b" : {
        "x" : 489,
        "y" : 343
      },
      "c" : {
        "x" : 492,
        "y" : 336
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 492,
        "y" : 336
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 481,
        "y" : 310
      },
      "b" : {
        "x" : 493,
        "y" : 322
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 487,
        "y" : 316
      }
    },
    "inputs" : [ {
      "id" : 138566,
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 138567
    } ]
  }, {
    "id" : 138570,
    "reactomeId" : 11042488,
    "displayName" : "p-STAT3 dimerizes",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2406,
      "y" : 274
    },
    "minX" : 2400,
    "maxX" : 2412,
    "minY" : 240,
    "maxY" : 307,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 2406,
        "y" : 240
      },
      "to" : {
        "x" : 2406,
        "y" : 274
      }
    }, {
      "from" : {
        "x" : 2406,
        "y" : 274
      },
      "to" : {
        "x" : 2406,
        "y" : 307
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2402,
        "y" : 300
      },
      "b" : {
        "x" : 2406,
        "y" : 307
      },
      "c" : {
        "x" : 2410,
        "y" : 300
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2410,
        "y" : 300
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2400,
        "y" : 268
      },
      "b" : {
        "x" : 2412,
        "y" : 280
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2406,
        "y" : 274
      }
    },
    "inputs" : [ {
      "id" : 138571,
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 138572
    } ]
  }, {
    "id" : 138568,
    "reactomeId" : 11031020,
    "displayName" : "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 491,
      "y" : 406
    },
    "minX" : 485,
    "maxX" : 497,
    "minY" : 375,
    "maxY" : 450,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 491,
        "y" : 375
      },
      "to" : {
        "x" : 491,
        "y" : 406
      }
    }, {
      "from" : {
        "x" : 491,
        "y" : 406
      },
      "to" : {
        "x" : 491,
        "y" : 450
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 487,
        "y" : 443
      },
      "b" : {
        "x" : 491,
        "y" : 450
      },
      "c" : {
        "x" : 495,
        "y" : 443
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 495,
        "y" : 443
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 485,
        "y" : 400
      },
      "b" : {
        "x" : 497,
        "y" : 412
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 491,
        "y" : 406
      }
    },
    "inputs" : [ {
      "id" : 138567
    } ],
    "outputs" : [ {
      "id" : 138569
    } ]
  }, {
    "id" : 138573,
    "reactomeId" : 11042446,
    "displayName" : "p-STAT1 dimerizes",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2296,
      "y" : 308
    },
    "minX" : 2290,
    "maxX" : 2302,
    "minY" : 269,
    "maxY" : 325,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 2296,
        "y" : 269
      },
      "to" : {
        "x" : 2296,
        "y" : 308
      }
    }, {
      "from" : {
        "x" : 2296,
        "y" : 308
      },
      "to" : {
        "x" : 2299,
        "y" : 325
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2294,
        "y" : 319
      },
      "b" : {
        "x" : 2299,
        "y" : 325
      },
      "c" : {
        "x" : 2302,
        "y" : 317
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2302,
        "y" : 317
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2290,
        "y" : 302
      },
      "b" : {
        "x" : 2302,
        "y" : 314
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2296,
        "y" : 308
      }
    },
    "inputs" : [ {
      "id" : 138574,
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 138575
    } ]
  } ],
  "compartments" : [ {
    "id" : 138583,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1500,
      "y" : 537
    },
    "minX" : 380,
    "maxX" : 2621,
    "minY" : 403,
    "maxY" : 671,
    "prop" : {
      "x" : 380,
      "y" : 403,
      "width" : 2241,
      "height" : 268
    },
    "textPosition" : {
      "x" : 393,
      "y" : 622
    },
    "insets" : {
      "x" : 390,
      "y" : 413,
      "width" : 2221,
      "height" : 248
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 138569, 138577, 138579, 138578, 138568 ]
  }, {
    "id" : 138580,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1953,
      "y" : 770
    },
    "minX" : 0,
    "maxX" : 3906,
    "minY" : 0,
    "maxY" : 1541,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 3906,
      "height" : 1541
    },
    "textPosition" : {
      "x" : 297,
      "y" : 1241
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 3886,
      "height" : 1521
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 138566, 138567, 138583, 138565, 138574, 138571, 138570, 138572, 138573, 138575, 138611, 138619, 138620, 138614, 138621, 138622, 138576, 138623, 138624, 138625 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 3906,
  "minY" : 0,
  "maxY" : 1541,
  "disease" : false
}