{
  "dbId" : 11050544,
  "stableId" : "R-DDI-5693571",
  "displayName" : "Nonhomologous End-Joining (NHEJ)",
  "nodes" : [ {
    "id" : 141986,
    "reactomeId" : 11029854,
    "displayName" : "dnapkcs",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1090,
      "y" : 676
    },
    "minX" : 1065,
    "maxX" : 1179,
    "minY" : 659,
    "maxY" : 689,
    "prop" : {
      "x" : 1065,
      "y" : 665,
      "width" : 50,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1066,
      "y" : 659
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1115,
          "y" : 665
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1115,
          "y" : 665
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141985,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1118,
          "y" : 679
        },
        "to" : {
          "x" : 1179,
          "y" : 687
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1142,
            "y" : 677
          },
          "b" : {
            "x" : 1154,
            "y" : 689
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1148,
            "y" : 683
          }
        }
      }
    } ]
  }, {
    "id" : 141987,
    "reactomeId" : 11029883,
    "displayName" : "XRCC5:XRCC6:DNA DSBs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1178,
      "y" : 620
    },
    "minX" : 1096,
    "maxX" : 1266,
    "minY" : 599,
    "maxY" : 687,
    "prop" : {
      "x" : 1096,
      "y" : 605,
      "width" : 164,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1100,
      "y" : 614
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1260,
          "y" : 605
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1260,
          "y" : 605
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141985,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1178,
          "y" : 638
        },
        "to" : {
          "x" : 1179,
          "y" : 687
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 141984,
    "reactomeId" : 11028067,
    "displayName" : "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 775,
      "y" : 497
    },
    "minX" : 618,
    "maxX" : 939,
    "minY" : 464,
    "maxY" : 546,
    "prop" : {
      "x" : 618,
      "y" : 470,
      "width" : 315,
      "height" : 54
    },
    "textPosition" : {
      "x" : 621,
      "y" : 475
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 933,
          "y" : 470
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 933,
          "y" : 470
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141980,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 773,
          "y" : 527
        },
        "to" : {
          "x" : 772,
          "y" : 546
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 777,
          "y" : 534
        },
        "b" : {
          "x" : 773,
          "y" : 527
        },
        "c" : {
          "x" : 769,
          "y" : 534
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 769,
          "y" : 534
        }
      }
    } ]
  }, {
    "id" : 141990,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1251,
      "y" : 808
    },
    "minX" : 1230,
    "maxX" : 1274,
    "minY" : 756,
    "maxY" : 820,
    "prop" : {
      "x" : 1230,
      "y" : 796,
      "width" : 43,
      "height" : 24
    },
    "textPosition" : {
      "x" : 1236,
      "y" : 797
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1268,
          "y" : 801
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1268,
          "y" : 801
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141989,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1253,
          "y" : 793
        },
        "to" : {
          "x" : 1263,
          "y" : 756
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 142023,
    "reactomeId" : 11049134,
    "displayName" : "DNA Double Strand Break Response",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 228,
      "y" : 160
    },
    "minX" : 128,
    "maxX" : 328,
    "minY" : 132,
    "maxY" : 188,
    "prop" : {
      "x" : 128,
      "y" : 132,
      "width" : 200,
      "height" : 56
    },
    "textPosition" : {
      "x" : 138,
      "y" : 138
    },
    "connectors" : [ ]
  }, {
    "id" : 141991,
    "reactomeId" : 11028036,
    "displayName" : "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:DNA DSB ends",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1442,
      "y" : 750
    },
    "minX" : 1313,
    "maxX" : 1550,
    "minY" : 721,
    "maxY" : 773,
    "prop" : {
      "x" : 1341,
      "y" : 727,
      "width" : 203,
      "height" : 46
    },
    "textPosition" : {
      "x" : 1344,
      "y" : 724
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1544,
          "y" : 727
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1544,
          "y" : 727
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141989,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1338,
          "y" : 753
        },
        "to" : {
          "x" : 1313,
          "y" : 755
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1331,
          "y" : 758
        },
        "b" : {
          "x" : 1338,
          "y" : 753
        },
        "c" : {
          "x" : 1331,
          "y" : 750
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1331,
          "y" : 750
        }
      }
    } ]
  }, {
    "id" : 141988,
    "reactomeId" : 11029858,
    "displayName" : "PRKDC:XRCC5:XRCC6:DNA DSB ends",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1168,
      "y" : 754
    },
    "minX" : 1097,
    "maxX" : 1284,
    "minY" : 724,
    "maxY" : 774,
    "prop" : {
      "x" : 1097,
      "y" : 735,
      "width" : 142,
      "height" : 39
    },
    "textPosition" : {
      "x" : 1099,
      "y" : 739
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1239,
          "y" : 735
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1239,
          "y" : 735
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141985,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 141989,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1242,
          "y" : 755
        },
        "to" : {
          "x" : 1263,
          "y" : 756
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 141989,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1232,
          "y" : 732
        },
        "to" : {
          "x" : 1267,
          "y" : 724
        }
      }, {
        "from" : {
          "x" : 1267,
          "y" : 724
        },
        "to" : {
          "x" : 1278,
          "y" : 742
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1280,
          "y" : 746
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1280,
          "y" : 746
        }
      }
    } ]
  }, {
    "id" : 141994,
    "reactomeId" : 11029830,
    "displayName" : "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Trimmed DNA DSB ends",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 755,
      "y" : 932
    },
    "minX" : 639,
    "maxX" : 877,
    "minY" : 903,
    "maxY" : 956,
    "prop" : {
      "x" : 639,
      "y" : 909,
      "width" : 232,
      "height" : 47
    },
    "textPosition" : {
      "x" : 644,
      "y" : 907
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 871,
          "y" : 909
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 871,
          "y" : 909
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141995,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 141993,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 142024,
    "reactomeId" : 11049162,
    "displayName" : "HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 230,
      "y" : 308
    },
    "minX" : 65,
    "maxX" : 396,
    "minY" : 269,
    "maxY" : 347,
    "prop" : {
      "x" : 65,
      "y" : 269,
      "width" : 331,
      "height" : 78
    },
    "textPosition" : {
      "x" : 63,
      "y" : 286
    },
    "connectors" : [ ]
  }, {
    "id" : 141992,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1319,
      "y" : 806
    },
    "minX" : 1295,
    "maxX" : 1344,
    "minY" : 755,
    "maxY" : 818,
    "prop" : {
      "x" : 1295,
      "y" : 794,
      "width" : 48,
      "height" : 24
    },
    "textPosition" : {
      "x" : 1302,
      "y" : 795
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1338,
          "y" : 799
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1338,
          "y" : 799
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141989,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1317,
          "y" : 791
        },
        "to" : {
          "x" : 1313,
          "y" : 755
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1312,
          "y" : 785
        },
        "b" : {
          "x" : 1317,
          "y" : 791
        },
        "c" : {
          "x" : 1320,
          "y" : 784
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1320,
          "y" : 784
        }
      }
    } ]
  }, {
    "id" : 141996,
    "reactomeId" : 11029852,
    "displayName" : "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Ligatable DNA DSB ends",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 755,
      "y" : 798
    },
    "minX" : 640,
    "maxX" : 877,
    "minY" : 766,
    "maxY" : 825,
    "prop" : {
      "x" : 640,
      "y" : 772,
      "width" : 231,
      "height" : 53
    },
    "textPosition" : {
      "x" : 644,
      "y" : 776
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 871,
          "y" : 772
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 871,
          "y" : 772
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141995,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 141997,
    "reactomeId" : 11029873,
    "displayName" : "(TDP1,TDP2)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 668,
      "y" : 870
    },
    "minX" : 640,
    "maxX" : 748,
    "minY" : 851,
    "maxY" : 889,
    "prop" : {
      "x" : 640,
      "y" : 851,
      "width" : 57,
      "height" : 38
    },
    "textPosition" : {
      "x" : 644,
      "y" : 852
    },
    "connectors" : [ {
      "edgeId" : 141995,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 703,
          "y" : 868
        },
        "to" : {
          "x" : 740,
          "y" : 867
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 744,
          "y" : 866
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 744,
          "y" : 866
        }
      }
    } ]
  }, {
    "id" : 141978,
    "reactomeId" : 11028042,
    "displayName" : "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:DNA DSB ends",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1103,
      "y" : 915
    },
    "minX" : 930,
    "maxX" : 1295,
    "minY" : 874,
    "maxY" : 943,
    "prop" : {
      "x" : 978,
      "y" : 888,
      "width" : 251,
      "height" : 55
    },
    "textPosition" : {
      "x" : 985,
      "y" : 894
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1229,
          "y" : 888
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1229,
          "y" : 888
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141975,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1232,
          "y" : 888
        },
        "to" : {
          "x" : 1295,
          "y" : 874
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1238,
          "y" : 883
        },
        "b" : {
          "x" : 1232,
          "y" : 888
        },
        "c" : {
          "x" : 1240,
          "y" : 890
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1240,
          "y" : 890
        }
      }
    }, {
      "edgeId" : 141993,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 141993,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 975,
          "y" : 900
        },
        "to" : {
          "x" : 941,
          "y" : 896
        }
      }, {
        "from" : {
          "x" : 941,
          "y" : 896
        },
        "to" : {
          "x" : 936,
          "y" : 910
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 934,
          "y" : 914
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 934,
          "y" : 914
        }
      }
    } ]
  }, {
    "id" : 141979,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1281,
      "y" : 931
    },
    "minX" : 1261,
    "maxX" : 1303,
    "minY" : 874,
    "maxY" : 943,
    "prop" : {
      "x" : 1261,
      "y" : 920,
      "width" : 41,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1265,
      "y" : 921
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1297,
          "y" : 925
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1297,
          "y" : 925
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141975,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1283,
          "y" : 917
        },
        "to" : {
          "x" : 1295,
          "y" : 874
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1281,
          "y" : 909
        },
        "b" : {
          "x" : 1283,
          "y" : 917
        },
        "c" : {
          "x" : 1289,
          "y" : 911
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1289,
          "y" : 911
        }
      }
    } ]
  }, {
    "id" : 141976,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1383,
      "y" : 928
    },
    "minX" : 1360,
    "maxX" : 1408,
    "minY" : 873,
    "maxY" : 939,
    "prop" : {
      "x" : 1360,
      "y" : 917,
      "width" : 47,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1368,
      "y" : 917
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1402,
          "y" : 922
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1402,
          "y" : 922
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141975,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1381,
          "y" : 914
        },
        "to" : {
          "x" : 1374,
          "y" : 873
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 141977,
    "reactomeId" : 11028038,
    "displayName" : "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S645-DCLRE1C:DNA DSB ends",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1552,
      "y" : 884
    },
    "minX" : 1338,
    "maxX" : 1707,
    "minY" : 841,
    "maxY" : 904,
    "prop" : {
      "x" : 1404,
      "y" : 865,
      "width" : 297,
      "height" : 39
    },
    "textPosition" : {
      "x" : 1412,
      "y" : 869
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1701,
          "y" : 865
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1701,
          "y" : 865
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141975,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1401,
          "y" : 874
        },
        "to" : {
          "x" : 1374,
          "y" : 873
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 141975,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1466,
          "y" : 862
        },
        "to" : {
          "x" : 1364,
          "y" : 841
        }
      }, {
        "from" : {
          "x" : 1364,
          "y" : 841
        },
        "to" : {
          "x" : 1345,
          "y" : 861
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1342,
          "y" : 864
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1342,
          "y" : 864
        }
      }
    } ]
  }, {
    "id" : 141982,
    "reactomeId" : 11028065,
    "displayName" : "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 770,
      "y" : 645
    },
    "minX" : 598,
    "maxX" : 949,
    "minY" : 571,
    "maxY" : 672,
    "prop" : {
      "x" : 598,
      "y" : 619,
      "width" : 345,
      "height" : 53
    },
    "textPosition" : {
      "x" : 603,
      "y" : 623
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 943,
          "y" : 619
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 943,
          "y" : 619
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141980,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 772,
          "y" : 616
        },
        "to" : {
          "x" : 775,
          "y" : 596
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 141980,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 793,
          "y" : 616
        },
        "to" : {
          "x" : 813,
          "y" : 597
        }
      }, {
        "from" : {
          "x" : 813,
          "y" : 597
        },
        "to" : {
          "x" : 787,
          "y" : 578
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 784,
          "y" : 575
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 784,
          "y" : 575
        }
      }
    } ]
  }, {
    "id" : 141983,
    "reactomeId" : 113541,
    "displayName" : "PPi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 707,
      "y" : 547
    },
    "minX" : 688,
    "maxX" : 772,
    "minY" : 531,
    "maxY" : 562,
    "prop" : {
      "x" : 688,
      "y" : 532,
      "width" : 38,
      "height" : 30
    },
    "textPosition" : {
      "x" : 693,
      "y" : 536
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 721,
          "y" : 537
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 721,
          "y" : 537
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141980,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 729,
          "y" : 546
        },
        "to" : {
          "x" : 772,
          "y" : 546
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 736,
          "y" : 542
        },
        "b" : {
          "x" : 729,
          "y" : 546
        },
        "c" : {
          "x" : 736,
          "y" : 550
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 736,
          "y" : 550
        }
      }
    } ]
  }, {
    "id" : 141981,
    "reactomeId" : 30555,
    "displayName" : "dNTP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 714,
      "y" : 598
    },
    "minX" : 689,
    "maxX" : 775,
    "minY" : 582,
    "maxY" : 613,
    "prop" : {
      "x" : 689,
      "y" : 583,
      "width" : 51,
      "height" : 30
    },
    "textPosition" : {
      "x" : 694,
      "y" : 587
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 735,
          "y" : 588
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 735,
          "y" : 588
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 141980,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 743,
          "y" : 597
        },
        "to" : {
          "x" : 775,
          "y" : 596
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 141985,
    "reactomeId" : 11029892,
    "displayName" : "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1181,
      "y" : 687
    },
    "minX" : 1171,
    "maxX" : 1187,
    "minY" : 681,
    "maxY" : 732,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1179,
        "y" : 687
      },
      "to" : {
        "x" : 1181,
        "y" : 687
      }
    }, {
      "from" : {
        "x" : 1181,
        "y" : 687
      },
      "to" : {
        "x" : 1171,
        "y" : 732
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1169,
        "y" : 724
      },
      "b" : {
        "x" : 1171,
        "y" : 732
      },
      "c" : {
        "x" : 1176,
        "y" : 726
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1176,
        "y" : 726
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1181,
        "y" : 687
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1181,
        "y" : 687
      }
    },
    "inputs" : [ {
      "id" : 141986,
      "points" : [ {
        "x" : 1118,
        "y" : 679
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 141987,
      "points" : [ {
        "x" : 1178,
        "y" : 638
      } ]
    } ],
    "outputs" : [ {
      "id" : 141988
    } ]
  }, {
    "id" : 141975,
    "reactomeId" : 11028045,
    "displayName" : "PRKDC phosphorylates DCLRE1C at DNA DSBs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1334,
      "y" : 873
    },
    "minX" : 1295,
    "maxX" : 1374,
    "minY" : 867,
    "maxY" : 879,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1374,
        "y" : 873
      },
      "to" : {
        "x" : 1334,
        "y" : 873
      }
    }, {
      "from" : {
        "x" : 1334,
        "y" : 873
      },
      "to" : {
        "x" : 1295,
        "y" : 874
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1328,
        "y" : 867
      },
      "b" : {
        "x" : 1340,
        "y" : 879
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1334,
        "y" : 873
      }
    },
    "inputs" : [ {
      "id" : 141976,
      "points" : [ {
        "x" : 1381,
        "y" : 914
      } ]
    }, {
      "id" : 141977,
      "points" : [ {
        "x" : 1401,
        "y" : 874
      } ]
    } ],
    "outputs" : [ {
      "id" : 141978,
      "points" : [ {
        "x" : 1232,
        "y" : 888
      } ]
    }, {
      "id" : 141979,
      "points" : [ {
        "x" : 1283,
        "y" : 917
      } ]
    } ],
    "catalysts" : [ {
      "id" : 141977,
      "points" : [ {
        "x" : 1466,
        "y" : 862
      }, {
        "x" : 1364,
        "y" : 841
      } ]
    } ]
  }, {
    "id" : 141989,
    "reactomeId" : 11029861,
    "displayName" : "DNA-PKcs autophosphorylates",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1286,
      "y" : 756
    },
    "minX" : 1263,
    "maxX" : 1313,
    "minY" : 750,
    "maxY" : 762,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1263,
        "y" : 756
      },
      "to" : {
        "x" : 1286,
        "y" : 756
      }
    }, {
      "from" : {
        "x" : 1286,
        "y" : 756
      },
      "to" : {
        "x" : 1313,
        "y" : 755
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1280,
        "y" : 750
      },
      "b" : {
        "x" : 1292,
        "y" : 762
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1286,
        "y" : 756
      }
    },
    "inputs" : [ {
      "id" : 141990,
      "points" : [ {
        "x" : 1253,
        "y" : 793
      } ]
    }, {
      "id" : 141988,
      "points" : [ {
        "x" : 1242,
        "y" : 755
      } ]
    } ],
    "outputs" : [ {
      "id" : 141991,
      "points" : [ {
        "x" : 1338,
        "y" : 753
      } ]
    }, {
      "id" : 141992,
      "points" : [ {
        "x" : 1317,
        "y" : 791
      } ]
    } ],
    "catalysts" : [ {
      "id" : 141988,
      "points" : [ {
        "x" : 1232,
        "y" : 732
      }, {
        "x" : 1267,
        "y" : 724
      } ]
    } ]
  }, {
    "id" : 141995,
    "reactomeId" : 11029876,
    "displayName" : "TDP1 and TDP2 process unligatable DSB ends",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 756,
      "y" : 866
    },
    "minX" : 750,
    "maxX" : 762,
    "minY" : 828,
    "maxY" : 906,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 755,
        "y" : 906
      },
      "to" : {
        "x" : 756,
        "y" : 866
      }
    }, {
      "from" : {
        "x" : 756,
        "y" : 866
      },
      "to" : {
        "x" : 755,
        "y" : 828
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 759,
        "y" : 835
      },
      "b" : {
        "x" : 755,
        "y" : 828
      },
      "c" : {
        "x" : 751,
        "y" : 835
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 751,
        "y" : 835
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 750,
        "y" : 860
      },
      "b" : {
        "x" : 762,
        "y" : 872
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 756,
        "y" : 866
      }
    },
    "inputs" : [ {
      "id" : 141994
    } ],
    "outputs" : [ {
      "id" : 141996
    } ],
    "catalysts" : [ {
      "id" : 141997,
      "points" : [ {
        "x" : 703,
        "y" : 868
      } ]
    } ]
  }, {
    "id" : 141993,
    "reactomeId" : 11029833,
    "displayName" : "DCLRE1C (ARTEMIS) processes DNA DSB ends",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 930,
      "y" : 925
    },
    "minX" : 874,
    "maxX" : 975,
    "minY" : 919,
    "maxY" : 931,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 975,
        "y" : 922
      },
      "to" : {
        "x" : 930,
        "y" : 925
      }
    }, {
      "from" : {
        "x" : 930,
        "y" : 925
      },
      "to" : {
        "x" : 874,
        "y" : 927
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 881,
        "y" : 923
      },
      "b" : {
        "x" : 874,
        "y" : 927
      },
      "c" : {
        "x" : 881,
        "y" : 931
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 881,
        "y" : 931
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 924,
        "y" : 919
      },
      "b" : {
        "x" : 936,
        "y" : 931
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 930,
        "y" : 925
      }
    },
    "inputs" : [ {
      "id" : 141978
    } ],
    "outputs" : [ {
      "id" : 141994
    } ],
    "catalysts" : [ {
      "id" : 141978,
      "points" : [ {
        "x" : 975,
        "y" : 900
      }, {
        "x" : 941,
        "y" : 896
      } ]
    } ]
  }, {
    "id" : 141980,
    "reactomeId" : 11028070,
    "displayName" : "POLL or POLM extends aligned DNA DSB ends to fill gaps",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 774,
      "y" : 568
    },
    "minX" : 768,
    "maxX" : 780,
    "minY" : 546,
    "maxY" : 596,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 775,
        "y" : 596
      },
      "to" : {
        "x" : 774,
        "y" : 568
      }
    }, {
      "from" : {
        "x" : 774,
        "y" : 568
      },
      "to" : {
        "x" : 772,
        "y" : 546
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 768,
        "y" : 562
      },
      "b" : {
        "x" : 780,
        "y" : 574
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 774,
        "y" : 568
      }
    },
    "inputs" : [ {
      "id" : 141981,
      "points" : [ {
        "x" : 743,
        "y" : 597
      } ]
    }, {
      "id" : 141982,
      "points" : [ {
        "x" : 772,
        "y" : 616
      } ]
    } ],
    "outputs" : [ {
      "id" : 141983,
      "points" : [ {
        "x" : 729,
        "y" : 546
      } ]
    }, {
      "id" : 141984,
      "points" : [ {
        "x" : 773,
        "y" : 527
      } ]
    } ],
    "catalysts" : [ {
      "id" : 141982,
      "points" : [ {
        "x" : 793,
        "y" : 616
      }, {
        "x" : 813,
        "y" : 597
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 141998,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 937,
      "y" : 542
    },
    "minX" : 0,
    "maxX" : 1875,
    "minY" : 0,
    "maxY" : 1085,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1875,
      "height" : 1085
    },
    "textPosition" : {
      "x" : 13,
      "y" : 1038
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1855,
      "height" : 1065
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 141999 ]
  }, {
    "id" : 141999,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 919,
      "y" : 540
    },
    "minX" : 36,
    "maxX" : 1803,
    "minY" : 35,
    "maxY" : 1046,
    "prop" : {
      "x" : 36,
      "y" : 35,
      "width" : 1767,
      "height" : 1011
    },
    "textPosition" : {
      "x" : 54,
      "y" : 991
    },
    "insets" : {
      "x" : 46,
      "y" : 45,
      "width" : 1747,
      "height" : 991
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 141987, 141986, 141988, 141997, 141977, 141991, 141975, 141976, 141978, 141979, 141996, 141980, 141981, 141983, 141984, 141985, 141989, 141993, 141995, 141982, 141994, 141990, 141992, 142023, 142024, 142027, 142028 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 142027,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 228,
      "y" : 228
    },
    "minX" : 222,
    "maxX" : 234,
    "minY" : 191,
    "maxY" : 266,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 228,
        "y" : 191
      },
      "to" : {
        "x" : 229,
        "y" : 266
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 225,
        "y" : 259
      },
      "b" : {
        "x" : 229,
        "y" : 266
      },
      "c" : {
        "x" : 233,
        "y" : 259
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 233,
        "y" : 259
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 222,
        "y" : 222
      },
      "b" : {
        "x" : 234,
        "y" : 234
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 228,
        "y" : 228
      }
    },
    "inputs" : [ {
      "id" : 142023
    } ],
    "outputs" : [ {
      "id" : 142024
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1875,
  "minY" : 0,
  "maxY" : 1085,
  "disease" : false
}