{ "dbId" : 11049718, "stableId" : "R-DDI-8939211", "displayName" : "ESR-mediated signaling", "nodes" : [ { "id" : 84225, "reactomeId" : 1254400, "displayName" : "ESTG", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 706, "y" : 334 }, "minX" : 597, "maxX" : 801, "minY" : 318, "maxY" : 459, "prop" : { "x" : 669, "y" : 319, "width" : 74, "height" : 30 }, "textPosition" : { "x" : 686, "y" : 323 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 738, "y" : 324 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 738, "y" : 324 } } }, "connectors" : [ { "edgeId" : 84227, "type" : "INPUT", "segments" : [ { "from" : { "x" : 692, "y" : 352 }, "to" : { "x" : 597, "y" : 459 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 84223, "type" : "INPUT", "segments" : [ { "from" : { "x" : 746, "y" : 334 }, "to" : { "x" : 801, "y" : 334 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 84224, "reactomeId" : 11040988, "displayName" : "ESR1:chaperone complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 758, "y" : 574 }, "minX" : 696, "maxX" : 856, "minY" : 334, "maxY" : 614, "prop" : { "x" : 696, "y" : 549, "width" : 124, "height" : 50 }, "textPosition" : { "x" : 700, "y" : 564 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 820, "y" : 549 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 820, "y" : 549 } } }, "connectors" : [ { "edgeId" : 84230, "type" : "INPUT", "segments" : [ { "from" : { "x" : 804, "y" : 546 }, "to" : { "x" : 853, "y" : 523 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 84233, "type" : "INPUT", "segments" : [ { "from" : { "x" : 819, "y" : 602 }, "to" : { "x" : 856, "y" : 614 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 84223, "type" : "INPUT", "segments" : [ { "from" : { "x" : 762, "y" : 546 }, "to" : { "x" : 801, "y" : 334 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 84226, "reactomeId" : 11040990, "displayName" : "ESTG:ESR1:chaperone complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 915, "y" : 333 }, "minX" : 871, "maxX" : 965, "minY" : 302, "maxY" : 358, "prop" : { "x" : 871, "y" : 308, "width" : 88, "height" : 50 }, "textPosition" : { "x" : 875, "y" : 309 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 959, "y" : 308 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 959, "y" : 308 } } }, "connectors" : [ { "edgeId" : 84223, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 84229, "reactomeId" : 11040996, "displayName" : "ESTG:ESR2:chaperone complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 696, "y" : 459 }, "minX" : 634, "maxX" : 764, "minY" : 428, "maxY" : 484, "prop" : { "x" : 634, "y" : 434, "width" : 124, "height" : 50 }, "textPosition" : { "x" : 656, "y" : 435 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 758, "y" : 434 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 758, "y" : 434 } } }, "connectors" : [ { "edgeId" : 84227, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 84228, "reactomeId" : 11040994, "displayName" : "ESR2:chaperone complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 505, "y" : 462 }, "minX" : 443, "maxX" : 597, "minY" : 431, "maxY" : 487, "prop" : { "x" : 443, "y" : 437, "width" : 124, "height" : 50 }, "textPosition" : { "x" : 447, "y" : 452 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 567, "y" : 437 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 567, "y" : 437 } } }, "connectors" : [ { "edgeId" : 84227, "type" : "INPUT", "segments" : [ { "from" : { "x" : 570, "y" : 459 }, "to" : { "x" : 597, "y" : 459 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 84231, "reactomeId" : 9716925, "displayName" : "ESR1 agonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 894, "y" : 559 }, "minX" : 850, "maxX" : 939, "minY" : 523, "maxY" : 570, "prop" : { "x" : 850, "y" : 548, "width" : 89, "height" : 22 }, "textPosition" : { "x" : 863, "y" : 542 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 84230, "type" : "INPUT", "segments" : [ { "from" : { "x" : 881, "y" : 542 }, "to" : { "x" : 853, "y" : 523 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 84232, "reactomeId" : 11045941, "displayName" : "ESR1:ESR1 agonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 855, "y" : 464 }, "minX" : 815, "maxX" : 901, "minY" : 440, "maxY" : 482, "prop" : { "x" : 815, "y" : 446, "width" : 80, "height" : 36 }, "textPosition" : { "x" : 815, "y" : 447 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 895, "y" : 446 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 895, "y" : 446 } } }, "connectors" : [ { "edgeId" : 84230, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 84235, "reactomeId" : 11045937, "displayName" : "ESR1:ESR1 antagonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 1001, "y" : 483 }, "minX" : 964, "maxX" : 1045, "minY" : 459, "maxY" : 501, "prop" : { "x" : 964, "y" : 465, "width" : 75, "height" : 36 }, "textPosition" : { "x" : 966, "y" : 438 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1039, "y" : 465 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1039, "y" : 465 } } }, "connectors" : [ { "edgeId" : 84233, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 84234, "reactomeId" : 9716906, "displayName" : "ESR1 antagonists", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 857, "y" : 660 }, "minX" : 804, "maxX" : 911, "minY" : 614, "maxY" : 671, "prop" : { "x" : 804, "y" : 649, "width" : 107, "height" : 22 }, "textPosition" : { "x" : 816, "y" : 643 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 84233, "type" : "INPUT", "segments" : [ { "from" : { "x" : 856, "y" : 643 }, "to" : { "x" : 856, "y" : 614 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 84272, "reactomeId" : 11043189, "displayName" : "ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3582, "y" : 2375 }, "minX" : 3520, "maxX" : 3650, "minY" : 2316, "maxY" : 2428, "prop" : { "x" : 3520, "y" : 2322, "width" : 124, "height" : 106 }, "textPosition" : { "x" : 3525, "y" : 2365 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3644, "y" : 2322 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3644, "y" : 2322 } } }, "connectors" : [ ] }, { "id" : 84215, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3601, "y" : 799 }, "minX" : 3503, "maxX" : 3632, "minY" : 729, "maxY" : 814, "prop" : { "x" : 3571, "y" : 784, "width" : 60, "height" : 30 }, "textPosition" : { "x" : 3585, "y" : 788 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3626, "y" : 789 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3626, "y" : 789 } } }, "connectors" : [ { "edgeId" : 84214, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3580, "y" : 781 }, "to" : { "x" : 3503, "y" : 729 } } ], "stoichiometry" : { "value" : 52, "shape" : { "a" : { "x" : 3535, "y" : 749 }, "b" : { "x" : 3547, "y" : 761 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3541, "y" : 755 } } } } ] }, { "id" : 84247, "reactomeId" : 11029685, "displayName" : "Ghost homologue of EP300", "schemaClass" : "GenomeEncodedEntity", "renderableClass" : "Protein", "position" : { "x" : 2561, "y" : 1308 }, "minX" : 2521, "maxX" : 2608, "minY" : 1291, "maxY" : 1319, "prop" : { "x" : 2521, "y" : 1297, "width" : 81, "height" : 22 }, "textPosition" : { "x" : 2521, "y" : 1284 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2602, "y" : 1297 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2602, "y" : 1297 } } }, "connectors" : [ ] }, { "id" : 84246, "reactomeId" : 11041156, "displayName" : "Homologues of CCND1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2903, "y" : 1033 }, "minX" : 2863, "maxX" : 2944, "minY" : 1022, "maxY" : 1044, "prop" : { "x" : 2863, "y" : 1022, "width" : 81, "height" : 22 }, "textPosition" : { "x" : 2864, "y" : 1016 }, "connectors" : [ ] }, { "id" : 84217, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3472, "y" : 820 }, "minX" : 3442, "maxX" : 3503, "minY" : 758, "maxY" : 835, "prop" : { "x" : 3442, "y" : 805, "width" : 60, "height" : 30 }, "textPosition" : { "x" : 3455, "y" : 809 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3497, "y" : 810 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3497, "y" : 810 } } }, "connectors" : [ { "edgeId" : 84214, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3467, "y" : 802 }, "to" : { "x" : 3455, "y" : 758 } } ], "stoichiometry" : { "value" : 52, "shape" : { "a" : { "x" : 3455, "y" : 774 }, "b" : { "x" : 3467, "y" : 786 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3461, "y" : 780 } } }, "endShape" : { "a" : { "x" : 3461, "y" : 796 }, "b" : { "x" : 3467, "y" : 802 }, "c" : { "x" : 3469, "y" : 794 }, "type" : "ARROW", "centre" : { "x" : 3469, "y" : 794 } } } ] }, { "id" : 84281, "reactomeId" : 11048880, "displayName" : "Mitotic G1 phase and G1/S transition", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2811, "y" : 958 }, "minX" : 2752, "maxX" : 2870, "minY" : 922, "maxY" : 994, "prop" : { "x" : 2752, "y" : 922, "width" : 118, "height" : 72 }, "textPosition" : { "x" : 2751, "y" : 929 }, "connectors" : [ ] }, { "id" : 84216, "reactomeId" : 11042576, "displayName" : "MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3552, "y" : 670 }, "minX" : 3438, "maxX" : 3620, "minY" : 604, "maxY" : 749, "prop" : { "x" : 3490, "y" : 610, "width" : 124, "height" : 120 }, "textPosition" : { "x" : 3490, "y" : 639 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3614, "y" : 610 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3614, "y" : 610 } } }, "connectors" : [ { "edgeId" : 84214, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3490, "y" : 729 }, "to" : { "x" : 3503, "y" : 729 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 84214, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3487, "y" : 697 }, "to" : { "x" : 3438, "y" : 721 } }, { "from" : { "x" : 3438, "y" : 721 }, "to" : { "x" : 3464, "y" : 742 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3468, "y" : 745 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3468, "y" : 745 } } } ] }, { "id" : 84218, "reactomeId" : 11042578, "displayName" : "MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3281, "y" : 791 }, "minX" : 3219, "maxX" : 3455, "minY" : 725, "maxY" : 851, "prop" : { "x" : 3219, "y" : 731, "width" : 124, "height" : 120 }, "textPosition" : { "x" : 3219, "y" : 760 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3343, "y" : 731 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3343, "y" : 731 } } }, "connectors" : [ { "edgeId" : 84214, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3346, "y" : 779 }, "to" : { "x" : 3455, "y" : 758 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3352, "y" : 774 }, "b" : { "x" : 3346, "y" : 779 }, "c" : { "x" : 3354, "y" : 782 }, "type" : "ARROW", "centre" : { "x" : 3354, "y" : 782 } } } ] }, { "id" : 84282, "reactomeId" : 11049716, "displayName" : "Extra-nuclear estrogen signaling", "schemaClass" : "Pathway", "renderableClass" : "ProcessNode", "position" : { "x" : 840, "y" : 96 }, "minX" : 789, "maxX" : 892, "minY" : 60, "maxY" : 132, "prop" : { "x" : 789, "y" : 60, "width" : 103, "height" : 72 }, "textPosition" : { "x" : 789, "y" : 67 }, "connectors" : [ ] }, { "id" : 84285, "reactomeId" : 11040998, "displayName" : "ESR:ESTG:chaperone complex", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1056, "y" : 334 }, "minX" : 990, "maxX" : 1123, "minY" : 316, "maxY" : 352, "prop" : { "x" : 990, "y" : 316, "width" : 133, "height" : 36 }, "textPosition" : { "x" : 991, "y" : 316 }, "connectors" : [ ] }, { "id" : 84221, "reactomeId" : 11043189, "displayName" : "ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3762, "y" : 2276 }, "minX" : 3700, "maxX" : 3877, "minY" : 2210, "maxY" : 2336, "prop" : { "x" : 3700, "y" : 2216, "width" : 124, "height" : 120 }, "textPosition" : { "x" : 3705, "y" : 2244 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3824, "y" : 2216 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3824, "y" : 2216 } } }, "connectors" : [ { "edgeId" : 84219, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3830, "y" : 2270 }, "to" : { "x" : 3877, "y" : 2265 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 84220, "reactomeId" : 11043173, "displayName" : "histone acetyltransferases", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3876, "y" : 2154 }, "minX" : 3814, "maxX" : 3938, "minY" : 2129, "maxY" : 2265, "prop" : { "x" : 3814, "y" : 2129, "width" : 124, "height" : 50 }, "textPosition" : { "x" : 3817, "y" : 2129 }, "connectors" : [ { "edgeId" : 84219, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3876, "y" : 2185 }, "to" : { "x" : 3877, "y" : 2265 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 84222, "reactomeId" : 11043191, "displayName" : "ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4010, "y" : 2262 }, "minX" : 3948, "maxX" : 4078, "minY" : 2189, "maxY" : 2329, "prop" : { "x" : 3948, "y" : 2195, "width" : 124, "height" : 134 }, "textPosition" : { "x" : 3952, "y" : 2252 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4072, "y" : 2195 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4072, "y" : 2195 } } }, "connectors" : [ { "edgeId" : 84219, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 84227, "reactomeId" : 11045815, "displayName" : "ESTG binds ESR2:chaperone complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 598, "y" : 459 }, "minX" : 592, "maxX" : 631, "minY" : 453, "maxY" : 465, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 597, "y" : 459 }, "to" : { "x" : 598, "y" : 459 } }, { "from" : { "x" : 598, "y" : 459 }, "to" : { "x" : 631, "y" : 459 } } ], "endShape" : { "a" : { "x" : 624, "y" : 463 }, "b" : { "x" : 631, "y" : 459 }, "c" : { "x" : 624, "y" : 455 }, "type" : "ARROW", "centre" : { "x" : 624, "y" : 455 } }, "reactionShape" : { "c" : { "x" : 598, "y" : 459 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 598, "y" : 459 } }, "inputs" : [ { "id" : 84228, "points" : [ { "x" : 570, "y" : 459 } ] }, { "id" : 84225, "points" : [ { "x" : 692, "y" : 352 } ] } ], "outputs" : [ { "id" : 84229 } ] }, { "id" : 84214, "reactomeId" : 11042581, "displayName" : "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3477, "y" : 752 }, "minX" : 3455, "maxX" : 3503, "minY" : 729, "maxY" : 758, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3503, "y" : 729 }, "to" : { "x" : 3477, "y" : 752 } }, { "from" : { "x" : 3477, "y" : 752 }, "to" : { "x" : 3455, "y" : 758 } } ], "reactionShape" : { "a" : { "x" : 3471, "y" : 746 }, "b" : { "x" : 3483, "y" : 758 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3477, "y" : 752 } }, "inputs" : [ { "id" : 84215, "points" : [ { "x" : 3580, "y" : 781 } ], "stoichiometry" : 52 }, { "id" : 84216, "points" : [ { "x" : 3490, "y" : 729 } ] } ], "outputs" : [ { "id" : 84217, "points" : [ { "x" : 3467, "y" : 802 } ], "stoichiometry" : 52 }, { "id" : 84218, "points" : [ { "x" : 3346, "y" : 779 } ] } ], "catalysts" : [ { "id" : 84216, "points" : [ { "x" : 3487, "y" : 697 }, { "x" : 3438, "y" : 721 } ] } ] }, { "id" : 84230, "reactomeId" : 11045943, "displayName" : "ESR1 binds ESR1 agonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 854, "y" : 523 }, "minX" : 848, "maxX" : 860, "minY" : 485, "maxY" : 529, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 853, "y" : 523 }, "to" : { "x" : 854, "y" : 523 } }, { "from" : { "x" : 854, "y" : 523 }, "to" : { "x" : 854, "y" : 485 } } ], "endShape" : { "a" : { "x" : 858, "y" : 492 }, "b" : { "x" : 854, "y" : 485 }, "c" : { "x" : 850, "y" : 492 }, "type" : "ARROW", "centre" : { "x" : 850, "y" : 492 } }, "reactionShape" : { "c" : { "x" : 854, "y" : 523 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 854, "y" : 523 } }, "inputs" : [ { "id" : 84231, "points" : [ { "x" : 881, "y" : 542 } ] }, { "id" : 84224, "points" : [ { "x" : 804, "y" : 546 } ] } ], "outputs" : [ { "id" : 84232 } ] }, { "id" : 84233, "reactomeId" : 11045939, "displayName" : "ESR1 binds ESR1 antagonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 857, "y" : 614 }, "minX" : 851, "maxX" : 1000, "minY" : 504, "maxY" : 620, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 856, "y" : 614 }, "to" : { "x" : 857, "y" : 614 } }, { "from" : { "x" : 857, "y" : 614 }, "to" : { "x" : 1000, "y" : 573 } }, { "from" : { "x" : 1000, "y" : 573 }, "to" : { "x" : 1000, "y" : 504 } } ], "endShape" : { "a" : { "x" : 1004, "y" : 511 }, "b" : { "x" : 1000, "y" : 504 }, "c" : { "x" : 996, "y" : 511 }, "type" : "ARROW", "centre" : { "x" : 996, "y" : 511 } }, "reactionShape" : { "c" : { "x" : 857, "y" : 614 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 857, "y" : 614 } }, "inputs" : [ { "id" : 84234, "points" : [ { "x" : 856, "y" : 643 } ] }, { "id" : 84224, "points" : [ { "x" : 819, "y" : 602 } ] } ], "outputs" : [ { "id" : 84235 } ] }, { "id" : 84219, "reactomeId" : 11043193, "displayName" : "Histone acetyltransferases are recruited to the TFF1 gene", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3909, "y" : 2263 }, "minX" : 3877, "maxX" : 3945, "minY" : 2257, "maxY" : 2269, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3877, "y" : 2265 }, "to" : { "x" : 3909, "y" : 2263 } }, { "from" : { "x" : 3909, "y" : 2263 }, "to" : { "x" : 3945, "y" : 2262 } } ], "endShape" : { "a" : { "x" : 3938, "y" : 2266 }, "b" : { "x" : 3945, "y" : 2262 }, "c" : { "x" : 3938, "y" : 2258 }, "type" : "ARROW", "centre" : { "x" : 3938, "y" : 2258 } }, "reactionShape" : { "c" : { "x" : 3909, "y" : 2263 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3909, "y" : 2263 } }, "inputs" : [ { "id" : 84220, "points" : [ { "x" : 3876, "y" : 2185 } ] }, { "id" : 84221, "points" : [ { "x" : 3830, "y" : 2270 } ] } ], "outputs" : [ { "id" : 84222 } ] }, { "id" : 84223, "reactomeId" : 11041000, "displayName" : "ESTG binds ESR1:chaperone complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 802, "y" : 333 }, "minX" : 796, "maxX" : 868, "minY" : 327, "maxY" : 339, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 801, "y" : 334 }, "to" : { "x" : 802, "y" : 333 } }, { "from" : { "x" : 802, "y" : 333 }, "to" : { "x" : 868, "y" : 333 } } ], "endShape" : { "a" : { "x" : 861, "y" : 337 }, "b" : { "x" : 868, "y" : 333 }, "c" : { "x" : 861, "y" : 329 }, "type" : "ARROW", "centre" : { "x" : 861, "y" : 329 } }, "reactionShape" : { "c" : { "x" : 802, "y" : 333 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 802, "y" : 333 } }, "inputs" : [ { "id" : 84224, "points" : [ { "x" : 762, "y" : 546 } ] }, { "id" : 84225, "points" : [ { "x" : 746, "y" : 334 } ] } ], "outputs" : [ { "id" : 84226 } ] } ], "compartments" : [ { "id" : 84274, "reactomeId" : 161320, "displayName" : "lysosomal lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 900, "y" : 925 }, "minX" : 812, "maxX" : 988, "minY" : 878, "maxY" : 972, "prop" : { "x" : 812, "y" : 878, "width" : 176, "height" : 94 }, "textPosition" : { "x" : 854, "y" : 890 }, "insets" : { "x" : 822, "y" : 888, "width" : 156, "height" : 74 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 84267, "reactomeId" : 17906, "displayName" : "mitochondrial outer membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 150, "y" : 2563 }, "minX" : 85, "maxX" : 216, "minY" : 2525, "maxY" : 2602, "prop" : { "x" : 85, "y" : 2525, "width" : 131, "height" : 77 }, "textPosition" : { "x" : 88, "y" : 2538 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 84266, "reactomeId" : 17963, "displayName" : "Golgi lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 237, "y" : 1862 }, "minX" : 169, "maxX" : 306, "minY" : 1823, "maxY" : 1902, "prop" : { "x" : 169, "y" : 1823, "width" : 137, "height" : 79 }, "textPosition" : { "x" : 193, "y" : 1826 }, "insets" : { "x" : 179, "y" : 1833, "width" : 117, "height" : 59 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 84237, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2347, "y" : 1499 }, "minX" : 406, "maxX" : 4288, "minY" : 224, "maxY" : 2775, "prop" : { "x" : 406, "y" : 224, "width" : 3882, "height" : 2551 }, "textPosition" : { "x" : 595, "y" : 272 }, "insets" : { "x" : 416, "y" : 234, "width" : 3862, "height" : 2531 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 84225, 84224, 84226, 84247, 84249, 84218, 84216, 84214, 84215, 84217, 84286, 84259, 84287, 84246, 84288, 84289, 84290, 84269, 84291, 84272, 84219, 84220, 84292, 84293, 84221, 84294, 84295, 84222, 84274, 84296, 84297, 84298, 84223, 84281, 84299, 84227, 84228, 84229, 84285, 84300, 84301, 84302, 84232, 84230, 84231, 84233, 84234, 84235 ] }, { "id" : 84236, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2296, "y" : 1518 }, "minX" : 0, "maxX" : 4593, "minY" : 0, "maxY" : 3036, "prop" : { "x" : 0, "y" : 0, "width" : 4593, "height" : 3036 }, "textPosition" : { "x" : 84, "y" : 80 }, "insets" : { "x" : 10, "y" : 10, "width" : 4573, "height" : 3016 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 84237, 84267, 84266, 84270, 84282 ] }, { "id" : 84270, "reactomeId" : 17957, "displayName" : "endoplasmic reticulum lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 4427, "y" : 1989 }, "minX" : 4313, "maxX" : 4541, "minY" : 1918, "maxY" : 2061, "prop" : { "x" : 4313, "y" : 1918, "width" : 228, "height" : 143 }, "textPosition" : { "x" : 4336, "y" : 1983 }, "insets" : { "x" : 4323, "y" : 1928, "width" : 208, "height" : 123 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } } ], "notes" : [ ], "links" : [ { "id" : 84293, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 3846, "y" : 1430 }, "minX" : 2605, "maxX" : 3874, "minY" : 1311, "maxY" : 2123, "segments" : [ { "from" : { "x" : 2605, "y" : 1311 }, "to" : { "x" : 3846, "y" : 1430 } }, { "from" : { "x" : 3846, "y" : 1430 }, "to" : { "x" : 3874, "y" : 2123 } } ], "reactionShape" : { "a" : { "x" : 3840, "y" : 1424 }, "b" : { "x" : 3852, "y" : 1436 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3846, "y" : 1430 } }, "inputs" : [ { "id" : 84247 } ], "outputs" : [ { "id" : 84220 } ] }, { "id" : 84294, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 3670, "y" : 2323 }, "minX" : 3647, "maxX" : 3694, "minY" : 2309, "maxY" : 2338, "segments" : [ { "from" : { "x" : 3647, "y" : 2338 }, "to" : { "x" : 3694, "y" : 2309 } } ], "reactionShape" : { "a" : { "x" : 3664, "y" : 2317 }, "b" : { "x" : 3676, "y" : 2329 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3670, "y" : 2323 } }, "inputs" : [ { "id" : 84272 } ], "outputs" : [ { "id" : 84221 } ] }, { "id" : 84299, "renderableClass" : "Interaction", "position" : { "x" : 2872, "y" : 1008 }, "minX" : 2856, "maxX" : 2888, "minY" : 997, "maxY" : 1019, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2888, "y" : 1019 }, "to" : { "x" : 2856, "y" : 997 } } ], "endShape" : { "a" : { "x" : 2864, "y" : 998 }, "b" : { "x" : 2856, "y" : 997 }, "c" : { "x" : 2859, "y" : 1004 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2859, "y" : 1004 } }, "reactionShape" : { "a" : { "x" : 2866, "y" : 1002 }, "b" : { "x" : 2878, "y" : 1014 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2872, "y" : 1008 } }, "inputs" : [ { "id" : 84246 } ], "outputs" : [ { "id" : 84281 } ] }, { "id" : 84301, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 973, "y" : 333 }, "minX" : 962, "maxX" : 984, "minY" : 327, "maxY" : 339, "segments" : [ { "from" : { "x" : 962, "y" : 333 }, "to" : { "x" : 984, "y" : 333 } } ], "reactionShape" : { "a" : { "x" : 967, "y" : 327 }, "b" : { "x" : 979, "y" : 339 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 973, "y" : 333 } }, "inputs" : [ { "id" : 84226 } ], "outputs" : [ { "id" : 84285 } ] }, { "id" : 84300, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 882, "y" : 398 }, "minX" : 761, "maxX" : 1004, "minY" : 358, "maxY" : 438, "segments" : [ { "from" : { "x" : 761, "y" : 438 }, "to" : { "x" : 1004, "y" : 358 } } ], "reactionShape" : { "a" : { "x" : 876, "y" : 392 }, "b" : { "x" : 888, "y" : 404 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 882, "y" : 398 } }, "inputs" : [ { "id" : 84229 } ], "outputs" : [ { "id" : 84285 } ] } ], "shadows" : [ { "id" : 84302, "reactomeId" : 11050762, "displayName" : "Estrogen-dependent gene expression", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 3645, "y" : 1473 }, "minX" : 3209, "maxX" : 4082, "minY" : 600, "maxY" : 2346, "prop" : { "x" : 3209, "y" : 600, "width" : 873, "height" : 1746 }, "points" : [ { "x" : 3209, "y" : 600 }, { "x" : 4082, "y" : 600 }, { "x" : 4082, "y" : 2346 }, { "x" : 3209, "y" : 2346 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 4593, "minY" : 0, "maxY" : 3036, "disease" : false }