{
  "dbId" : 11049648,
  "stableId" : "R-DDI-166058",
  "displayName" : "MyD88:MAL(TIRAP) cascade initiated on plasma membrane",
  "nodes" : [ {
    "id" : 145202,
    "reactomeId" : 11014014,
    "displayName" : "TRAF6:p-IRAK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 428,
      "y" : 104
    },
    "minX" : 378,
    "maxX" : 485,
    "minY" : 87,
    "maxY" : 133,
    "prop" : {
      "x" : 378,
      "y" : 93,
      "width" : 101,
      "height" : 22
    },
    "textPosition" : {
      "x" : 380,
      "y" : 94
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 479,
          "y" : 93
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 479,
          "y" : 93
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 145201,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 444,
          "y" : 118
        },
        "to" : {
          "x" : 472,
          "y" : 133
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 145203,
    "reactomeId" : 11003938,
    "displayName" : "Homologues of TRAF6",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 461,
      "y" : 183
    },
    "minX" : 438,
    "maxX" : 484,
    "minY" : 133,
    "maxY" : 194,
    "prop" : {
      "x" : 438,
      "y" : 172,
      "width" : 46,
      "height" : 22
    },
    "textPosition" : {
      "x" : 438,
      "y" : 152
    },
    "connectors" : [ {
      "edgeId" : 145201,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 463,
          "y" : 169
        },
        "to" : {
          "x" : 472,
          "y" : 133
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 461,
            "y" : 145
          },
          "b" : {
            "x" : 473,
            "y" : 157
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 467,
            "y" : 151
          }
        }
      }
    } ]
  }, {
    "id" : 145219,
    "reactomeId" : 11049646,
    "displayName" : "MAP kinase activation",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 1093,
      "y" : 353
    },
    "minX" : 1032,
    "maxX" : 1155,
    "minY" : 324,
    "maxY" : 382,
    "prop" : {
      "x" : 1032,
      "y" : 324,
      "width" : 123,
      "height" : 58
    },
    "textPosition" : {
      "x" : 1048,
      "y" : 331
    },
    "connectors" : [ ]
  }, {
    "id" : 145206,
    "reactomeId" : 10997226,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 595,
      "y" : 159
    },
    "minX" : 583,
    "maxX" : 623,
    "minY" : 124,
    "maxY" : 170,
    "prop" : {
      "x" : 583,
      "y" : 148,
      "width" : 25,
      "height" : 22
    },
    "textPosition" : {
      "x" : 583,
      "y" : 148
    },
    "connectors" : [ {
      "edgeId" : 145205,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 603,
          "y" : 142
        },
        "to" : {
          "x" : 623,
          "y" : 124
        }
      } ],
      "stoichiometry" : {
        "value" : 9,
        "shape" : {
          "a" : {
            "x" : 607,
            "y" : 127
          },
          "b" : {
            "x" : 619,
            "y" : 139
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 613,
            "y" : 133
          }
        }
      }
    }, {
      "edgeId" : 145208,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 145207,
    "reactomeId" : 11014092,
    "displayName" : "p-IRAK2:K63-linked pUb oligo-TRAF6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 753,
      "y" : 96
    },
    "minX" : 668,
    "maxX" : 824,
    "minY" : 72,
    "maxY" : 156,
    "prop" : {
      "x" : 689,
      "y" : 78,
      "width" : 129,
      "height" : 36
    },
    "textPosition" : {
      "x" : 690,
      "y" : 79
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 818,
          "y" : 78
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 818,
          "y" : 78
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 145205,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 145208,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 727,
          "y" : 117
        },
        "to" : {
          "x" : 675,
          "y" : 150
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 672,
          "y" : 152
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 672,
          "y" : 152
        }
      }
    } ]
  }, {
    "id" : 145220,
    "reactomeId" : 11050910,
    "displayName" : "TAK1-dependent IKK and NF-kappa-B activation",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 1233,
      "y" : 340
    },
    "minX" : 1171,
    "maxX" : 1296,
    "minY" : 297,
    "maxY" : 383,
    "prop" : {
      "x" : 1171,
      "y" : 297,
      "width" : 125,
      "height" : 86
    },
    "textPosition" : {
      "x" : 1172,
      "y" : 304
    },
    "connectors" : [ ]
  }, {
    "id" : 145204,
    "reactomeId" : 11014016,
    "displayName" : "p-IRAK2:oligo-TRAF6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 546,
      "y" : 96
    },
    "minX" : 499,
    "maxX" : 659,
    "minY" : 72,
    "maxY" : 124,
    "prop" : {
      "x" : 499,
      "y" : 78,
      "width" : 94,
      "height" : 36
    },
    "textPosition" : {
      "x" : 500,
      "y" : 79
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 593,
          "y" : 78
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 593,
          "y" : 78
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 145201,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 145205,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 596,
          "y" : 113
        },
        "to" : {
          "x" : 623,
          "y" : 124
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 145205,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 596,
          "y" : 96
        },
        "to" : {
          "x" : 652,
          "y" : 97
        }
      }, {
        "from" : {
          "x" : 652,
          "y" : 97
        },
        "to" : {
          "x" : 654,
          "y" : 108
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 655,
          "y" : 112
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 655,
          "y" : 112
        }
      }
    } ]
  }, {
    "id" : 145240,
    "reactomeId" : 11050636,
    "displayName" : "Regulation of TLR by endogenous ligand",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 89,
      "y" : 27
    },
    "minX" : 0,
    "maxX" : 178,
    "minY" : 0,
    "maxY" : 55,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 178,
      "height" : 55
    },
    "textPosition" : {
      "x" : 16,
      "y" : 6
    },
    "connectors" : [ ]
  }, {
    "id" : 145209,
    "reactomeId" : 11004110,
    "displayName" : "K63polyUb",
    "schemaClass" : "Polymer",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 772,
      "y" : 160
    },
    "minX" : 735,
    "maxX" : 809,
    "minY" : 149,
    "maxY" : 171,
    "prop" : {
      "x" : 735,
      "y" : 149,
      "width" : 74,
      "height" : 22
    },
    "textPosition" : {
      "x" : 735,
      "y" : 149
    },
    "connectors" : [ {
      "edgeId" : 145208,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 145201,
    "reactomeId" : 11014097,
    "displayName" : "IRAK2 induces TRAF6 oligomerization",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 492,
      "y" : 131
    },
    "minX" : 472,
    "maxX" : 518,
    "minY" : 117,
    "maxY" : 137,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 472,
        "y" : 133
      },
      "to" : {
        "x" : 492,
        "y" : 131
      }
    }, {
      "from" : {
        "x" : 492,
        "y" : 131
      },
      "to" : {
        "x" : 518,
        "y" : 117
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 514,
        "y" : 124
      },
      "b" : {
        "x" : 518,
        "y" : 117
      },
      "c" : {
        "x" : 510,
        "y" : 117
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 510,
        "y" : 117
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 492,
        "y" : 131
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 492,
        "y" : 131
      }
    },
    "inputs" : [ {
      "id" : 145202,
      "points" : [ {
        "x" : 444,
        "y" : 118
      } ]
    }, {
      "id" : 145203,
      "points" : [ {
        "x" : 463,
        "y" : 169
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 145204
    } ]
  }, {
    "id" : 145205,
    "reactomeId" : 11014095,
    "displayName" : "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 657,
      "y" : 124
    },
    "minX" : 623,
    "maxX" : 691,
    "minY" : 117,
    "maxY" : 130,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 623,
        "y" : 124
      },
      "to" : {
        "x" : 657,
        "y" : 124
      }
    }, {
      "from" : {
        "x" : 657,
        "y" : 124
      },
      "to" : {
        "x" : 691,
        "y" : 117
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 685,
        "y" : 122
      },
      "b" : {
        "x" : 691,
        "y" : 117
      },
      "c" : {
        "x" : 683,
        "y" : 114
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 683,
        "y" : 114
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 651,
        "y" : 118
      },
      "b" : {
        "x" : 663,
        "y" : 130
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 657,
        "y" : 124
      }
    },
    "inputs" : [ {
      "id" : 145204,
      "points" : [ {
        "x" : 596,
        "y" : 113
      } ]
    }, {
      "id" : 145206,
      "points" : [ {
        "x" : 603,
        "y" : 142
      } ],
      "stoichiometry" : 9
    } ],
    "outputs" : [ {
      "id" : 145207
    } ],
    "catalysts" : [ {
      "id" : 145204,
      "points" : [ {
        "x" : 596,
        "y" : 96
      }, {
        "x" : 652,
        "y" : 97
      } ]
    } ]
  }, {
    "id" : 145208,
    "reactomeId" : 11014100,
    "displayName" : "Activated TRAF6 synthesizes unanchored polyubiquitin chains",
    "schemaClass" : "Polymerisation",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 662,
      "y" : 159
    },
    "minX" : 614,
    "maxX" : 732,
    "minY" : 153,
    "maxY" : 165,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 614,
        "y" : 159
      },
      "to" : {
        "x" : 662,
        "y" : 159
      }
    }, {
      "from" : {
        "x" : 662,
        "y" : 159
      },
      "to" : {
        "x" : 732,
        "y" : 159
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 725,
        "y" : 163
      },
      "b" : {
        "x" : 732,
        "y" : 159
      },
      "c" : {
        "x" : 725,
        "y" : 155
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 725,
        "y" : 155
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 662,
        "y" : 159
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 662,
        "y" : 159
      }
    },
    "inputs" : [ {
      "id" : 145206
    } ],
    "outputs" : [ {
      "id" : 145209
    } ],
    "catalysts" : [ {
      "id" : 145207,
      "points" : [ {
        "x" : 727,
        "y" : 117
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 145210,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 802,
      "y" : 545
    },
    "minX" : 93,
    "maxX" : 1511,
    "minY" : 104,
    "maxY" : 986,
    "prop" : {
      "x" : 93,
      "y" : 104,
      "width" : 1418,
      "height" : 882
    },
    "textPosition" : {
      "x" : 552,
      "y" : 553
    },
    "insets" : {
      "x" : 103,
      "y" : 114,
      "width" : 1398,
      "height" : 862
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 145219, 145220, 145202, 145204, 145201, 145203, 145205, 145206, 145207, 145208, 145209, 145241, 145242, 145243 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ {
    "id" : 145241,
    "reactomeId" : 11050108,
    "displayName" : "IRAK2 mediated activation of TAK1 complex",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 598,
      "y" : 136
    },
    "minX" : 368,
    "maxX" : 828,
    "minY" : 68,
    "maxY" : 204,
    "prop" : {
      "x" : 368,
      "y" : 68,
      "width" : 460,
      "height" : 136
    },
    "points" : [ {
      "x" : 368,
      "y" : 68
    }, {
      "x" : 828,
      "y" : 68
    }, {
      "x" : 828,
      "y" : 204
    }, {
      "x" : 368,
      "y" : 204
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 1511,
  "minY" : 0,
  "maxY" : 986,
  "disease" : false
}