{ "dbId" : 11048870, "stableId" : "R-DDI-69242", "displayName" : "S Phase", "nodes" : [ { "id" : 106881, "reactomeId" : 11004707, "displayName" : "CCNA:p-Y15-CDK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 147, "y" : 419 }, "minX" : 83, "maxX" : 271, "minY" : 391, "maxY" : 433, "prop" : { "x" : 83, "y" : 405, "width" : 129, "height" : 28 }, "textPosition" : { "x" : 89, "y" : 412 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 212, "y" : 405 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 212, "y" : 405 } } }, "connectors" : [ { "edgeId" : 106884, "type" : "INPUT", "segments" : [ { "from" : { "x" : 202, "y" : 402 }, "to" : { "x" : 257, "y" : 391 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 106878, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 215, "y" : 422 }, "to" : { "x" : 271, "y" : 426 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 222, "y" : 419 }, "b" : { "x" : 215, "y" : 422 }, "c" : { "x" : 222, "y" : 426 }, "type" : "ARROW", "centre" : { "x" : 222, "y" : 426 } } } ] }, { "id" : 106880, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 247, "y" : 470 }, "minX" : 224, "maxX" : 271, "minY" : 426, "maxY" : 485, "prop" : { "x" : 224, "y" : 455, "width" : 46, "height" : 30 }, "textPosition" : { "x" : 230, "y" : 459 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 265, "y" : 460 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 265, "y" : 460 } } }, "connectors" : [ { "edgeId" : 106878, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 255, "y" : 452 }, "to" : { "x" : 271, "y" : 426 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 255, "y" : 444 }, "b" : { "x" : 255, "y" : 452 }, "c" : { "x" : 262, "y" : 448 }, "type" : "ARROW", "centre" : { "x" : 262, "y" : 448 } } } ] }, { "id" : 106883, "reactomeId" : 10997691, "displayName" : "CABLES1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 273, "y" : 501 }, "minX" : 244, "maxX" : 330, "minY" : 433, "maxY" : 512, "prop" : { "x" : 244, "y" : 490, "width" : 59, "height" : 22 }, "textPosition" : { "x" : 246, "y" : 484 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 303, "y" : 490 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 303, "y" : 490 } } }, "connectors" : [ { "edgeId" : 106878, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 282, "y" : 487 }, "to" : { "x" : 330, "y" : 433 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 328, "y" : 441 }, "b" : { "x" : 330, "y" : 433 }, "c" : { "x" : 322, "y" : 436 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 322, "y" : 436 } } } ] }, { "id" : 106882, "reactomeId" : 10997685, "displayName" : "WEE1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 336, "y" : 477 }, "minX" : 313, "maxX" : 365, "minY" : 434, "maxY" : 488, "prop" : { "x" : 313, "y" : 466, "width" : 46, "height" : 22 }, "textPosition" : { "x" : 314, "y" : 466 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 359, "y" : 466 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 359, "y" : 466 } } }, "connectors" : [ { "edgeId" : 106878, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 336, "y" : 463 }, "to" : { "x" : 336, "y" : 442 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 336, "y" : 438 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 336, "y" : 438 } } } ] }, { "id" : 106885, "reactomeId" : 113518, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 219, "y" : 360 }, "minX" : 196, "maxX" : 257, "minY" : 344, "maxY" : 391, "prop" : { "x" : 196, "y" : 345, "width" : 46, "height" : 30 }, "textPosition" : { "x" : 202, "y" : 349 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 237, "y" : 350 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 237, "y" : 350 } } }, "connectors" : [ { "edgeId" : 106884, "type" : "INPUT", "segments" : [ { "from" : { "x" : 237, "y" : 378 }, "to" : { "x" : 257, "y" : 391 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 106887, "reactomeId" : 10997699, "displayName" : "cdc25", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 327, "y" : 335 }, "minX" : 289, "maxX" : 371, "minY" : 318, "maxY" : 383, "prop" : { "x" : 289, "y" : 324, "width" : 76, "height" : 22 }, "textPosition" : { "x" : 304, "y" : 324 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 365, "y" : 324 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 365, "y" : 324 } } }, "connectors" : [ { "edgeId" : 106884, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 327, "y" : 352 }, "to" : { "x" : 328, "y" : 375 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 328, "y" : 379 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 328, "y" : 379 } } } ] }, { "id" : 106886, "reactomeId" : 113550, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 430, "y" : 355 }, "minX" : 395, "maxX" : 447, "minY" : 339, "maxY" : 391, "prop" : { "x" : 415, "y" : 340, "width" : 31, "height" : 30 }, "textPosition" : { "x" : 421, "y" : 344 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 441, "y" : 345 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 441, "y" : 345 } } }, "connectors" : [ { "edgeId" : 106884, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 415, "y" : 373 }, "to" : { "x" : 395, "y" : 391 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 413, "y" : 381 }, "b" : { "x" : 415, "y" : 373 }, "c" : { "x" : 407, "y" : 375 }, "type" : "ARROW", "centre" : { "x" : 407, "y" : 375 } } } ] }, { "id" : 106889, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 596, "y" : 450 }, "minX" : 577, "maxX" : 617, "minY" : 411, "maxY" : 465, "prop" : { "x" : 577, "y" : 435, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 581, "y" : 439 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 611, "y" : 440 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 611, "y" : 440 } } }, "connectors" : [ { "edgeId" : 106888, "type" : "INPUT", "segments" : [ { "from" : { "x" : 602, "y" : 432 }, "to" : { "x" : 613, "y" : 411 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 106891, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 705, "y" : 449 }, "minX" : 682, "maxX" : 729, "minY" : 411, "maxY" : 464, "prop" : { "x" : 682, "y" : 434, "width" : 46, "height" : 30 }, "textPosition" : { "x" : 688, "y" : 438 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 723, "y" : 439 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 723, "y" : 439 } } }, "connectors" : [ { "edgeId" : 106888, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 696, "y" : 431 }, "to" : { "x" : 683, "y" : 411 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 689, "y" : 427 }, "b" : { "x" : 696, "y" : 431 }, "c" : { "x" : 696, "y" : 423 }, "type" : "ARROW", "centre" : { "x" : 696, "y" : 423 } } } ] }, { "id" : 106890, "reactomeId" : 10997015, "displayName" : "CCNA:p-T160-CDK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 735, "y" : 368 }, "minX" : 667, "maxX" : 1114, "minY" : 352, "maxY" : 528, "prop" : { "x" : 667, "y" : 358, "width" : 137, "height" : 21 }, "textPosition" : { "x" : 673, "y" : 358 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 804, "y" : 358 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 804, "y" : 358 } } }, "connectors" : [ { "edgeId" : 106888, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 722, "y" : 382 }, "to" : { "x" : 683, "y" : 411 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 719, "y" : 389 }, "b" : { "x" : 722, "y" : 382 }, "c" : { "x" : 714, "y" : 383 }, "type" : "ARROW", "centre" : { "x" : 714, "y" : 383 } } }, { "edgeId" : 106893, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 760, "y" : 382 }, "to" : { "x" : 1106, "y" : 523 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1110, "y" : 524 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1110, "y" : 524 } } } ] }, { "id" : 106892, "reactomeId" : 11000207, "displayName" : "CAK", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 649, "y" : 341 }, "minX" : 624, "maxX" : 681, "minY" : 325, "maxY" : 403, "prop" : { "x" : 624, "y" : 331, "width" : 51, "height" : 21 }, "textPosition" : { "x" : 634, "y" : 331 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 675, "y" : 331 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 675, "y" : 331 } } }, "connectors" : [ { "edgeId" : 106888, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 649, "y" : 355 }, "to" : { "x" : 649, "y" : 395 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 649, "y" : 399 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 649, "y" : 399 } } } ] }, { "id" : 106895, "reactomeId" : 11005076, "displayName" : "FZR1,p-S795-RB1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 923, "y" : 551 }, "minX" : 853, "maxX" : 1041, "minY" : 533, "maxY" : 570, "prop" : { "x" : 853, "y" : 533, "width" : 140, "height" : 37 }, "textPosition" : { "x" : 865, "y" : 541 }, "connectors" : [ { "edgeId" : 106893, "type" : "INPUT", "segments" : [ { "from" : { "x" : 999, "y" : 549 }, "to" : { "x" : 1041, "y" : 548 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 106894, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1043, "y" : 628 }, "minX" : 1022, "maxX" : 1065, "minY" : 548, "maxY" : 642, "prop" : { "x" : 1022, "y" : 614, "width" : 42, "height" : 28 }, "textPosition" : { "x" : 1027, "y" : 617 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1059, "y" : 619 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1059, "y" : 619 } } }, "connectors" : [ { "edgeId" : 106893, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1042, "y" : 611 }, "to" : { "x" : 1041, "y" : 548 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 106897, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1152, "y" : 453 }, "minX" : 1132, "maxX" : 1186, "minY" : 438, "maxY" : 512, "prop" : { "x" : 1132, "y" : 439, "width" : 41, "height" : 28 }, "textPosition" : { "x" : 1136, "y" : 442 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1168, "y" : 444 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1168, "y" : 444 } } }, "connectors" : [ { "edgeId" : 106893, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1160, "y" : 470 }, "to" : { "x" : 1186, "y" : 512 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1167, "y" : 474 }, "b" : { "x" : 1160, "y" : 470 }, "c" : { "x" : 1160, "y" : 478 }, "type" : "ARROW", "centre" : { "x" : 1160, "y" : 478 } } } ] }, { "id" : 106896, "reactomeId" : 11005078, "displayName" : "p-FZR1,p-RB1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1319, "y" : 465 }, "minX" : 1186, "maxX" : 1390, "minY" : 442, "maxY" : 512, "prop" : { "x" : 1249, "y" : 442, "width" : 141, "height" : 47 }, "textPosition" : { "x" : 1273, "y" : 455 }, "connectors" : [ { "edgeId" : 106893, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1252, "y" : 495 }, "to" : { "x" : 1186, "y" : 512 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1246, "y" : 501 }, "b" : { "x" : 1252, "y" : 495 }, "c" : { "x" : 1244, "y" : 493 }, "type" : "ARROW", "centre" : { "x" : 1244, "y" : 493 } } } ] }, { "id" : 106899, "reactomeId" : 11001227, "displayName" : "phospho(T286)-Cyclin D1:Cdk4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1700, "y" : 536 }, "minX" : 1640, "maxX" : 1767, "minY" : 512, "maxY" : 554, "prop" : { "x" : 1640, "y" : 518, "width" : 121, "height" : 36 }, "textPosition" : { "x" : 1646, "y" : 519 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1761, "y" : 518 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1761, "y" : 518 } } }, "connectors" : [ { "edgeId" : 106898, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 106900, "reactomeId" : 11001237, "displayName" : "phospho(T286)-Cyclin D1:Cdk4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2007, "y" : 525 }, "minX" : 1947, "maxX" : 2074, "minY" : 501, "maxY" : 543, "prop" : { "x" : 1947, "y" : 507, "width" : 121, "height" : 36 }, "textPosition" : { "x" : 1953, "y" : 508 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2068, "y" : 507 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2068, "y" : 507 } } }, "connectors" : [ { "edgeId" : 106898, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 106903, "reactomeId" : 11001233, "displayName" : "Homologues of p-T286-CCND1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2028, "y" : 465 }, "minX" : 1972, "maxX" : 2085, "minY" : 447, "maxY" : 483, "prop" : { "x" : 1972, "y" : 447, "width" : 113, "height" : 36 }, "textPosition" : { "x" : 1975, "y" : 447 }, "connectors" : [ { "edgeId" : 106901, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 106902, "reactomeId" : 11001223, "displayName" : "Homologues of p-T286-CCND1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1640, "y" : 480 }, "minX" : 1584, "maxX" : 1697, "minY" : 462, "maxY" : 498, "prop" : { "x" : 1584, "y" : 462, "width" : 113, "height" : 36 }, "textPosition" : { "x" : 1587, "y" : 462 }, "connectors" : [ { "edgeId" : 106901, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 106905, "reactomeId" : 11001243, "displayName" : "multi-ubiquitinated phospho-(T286) Cyclin D1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1945, "y" : 282 }, "minX" : 1885, "maxX" : 2012, "minY" : 244, "maxY" : 314, "prop" : { "x" : 1885, "y" : 250, "width" : 121, "height" : 64 }, "textPosition" : { "x" : 1889, "y" : 251 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2006, "y" : 250 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2006, "y" : 250 } } }, "connectors" : [ { "edgeId" : 106904, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 106907, "reactomeId" : 10997410, "displayName" : "26S proteasome", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2131, "y" : 125 }, "minX" : 2027, "maxX" : 2198, "minY" : 108, "maxY" : 265, "prop" : { "x" : 2071, "y" : 114, "width" : 121, "height" : 22 }, "textPosition" : { "x" : 2075, "y" : 115 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2192, "y" : 114 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2192, "y" : 114 } } }, "connectors" : [ { "edgeId" : 106904, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2113, "y" : 139 }, "to" : { "x" : 2030, "y" : 190 } }, { "from" : { "x" : 2030, "y" : 190 }, "to" : { "x" : 2031, "y" : 257 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2031, "y" : 261 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2031, "y" : 261 } } } ] }, { "id" : 106906, "reactomeId" : 10997226, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2159, "y" : 278 }, "minX" : 2067, "maxX" : 2197, "minY" : 267, "maxY" : 289, "prop" : { "x" : 2121, "y" : 267, "width" : 76, "height" : 22 }, "textPosition" : { "x" : 2146, "y" : 267 }, "connectors" : [ { "edgeId" : 106904, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 2067, "y" : 268 }, "b" : { "x" : 2079, "y" : 280 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2073, "y" : 274 } } } } ] }, { "id" : 106909, "reactomeId" : 113560, "displayName" : "Ac-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1303, "y" : 729 }, "minX" : 1235, "maxX" : 1372, "minY" : 715, "maxY" : 742, "prop" : { "x" : 1269, "y" : 716, "width" : 69, "height" : 26 }, "textPosition" : { "x" : 1278, "y" : 718 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1333, "y" : 721 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1333, "y" : 721 } } }, "connectors" : [ { "edgeId" : 106914, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1266, "y" : 729 }, "to" : { "x" : 1235, "y" : 730 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1244, "y" : 723 }, "b" : { "x" : 1256, "y" : 735 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1250, "y" : 729 } } } }, { "edgeId" : 106908, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1341, "y" : 729 }, "to" : { "x" : 1372, "y" : 730 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1350, "y" : 723 }, "b" : { "x" : 1362, "y" : 735 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1356, "y" : 729 } } } } ] }, { "id" : 106911, "reactomeId" : 2485002, "displayName" : "CoA-SH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1305, "y" : 810 }, "minX" : 1238, "maxX" : 1372, "minY" : 794, "maxY" : 825, "prop" : { "x" : 1274, "y" : 795, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 1279, "y" : 799 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1332, "y" : 800 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1332, "y" : 800 } } }, "connectors" : [ { "edgeId" : 106914, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1271, "y" : 808 }, "to" : { "x" : 1238, "y" : 807 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1248, "y" : 801 }, "b" : { "x" : 1260, "y" : 813 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1254, "y" : 807 } } }, "endShape" : { "a" : { "x" : 1264, "y" : 812 }, "b" : { "x" : 1271, "y" : 808 }, "c" : { "x" : 1264, "y" : 804 }, "type" : "ARROW", "centre" : { "x" : 1264, "y" : 804 } } }, { "edgeId" : 106908, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1340, "y" : 809 }, "to" : { "x" : 1372, "y" : 808 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1350, "y" : 802 }, "b" : { "x" : 1362, "y" : 814 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1356, "y" : 808 } } }, "endShape" : { "a" : { "x" : 1347, "y" : 805 }, "b" : { "x" : 1340, "y" : 809 }, "c" : { "x" : 1347, "y" : 813 }, "type" : "ARROW", "centre" : { "x" : 1347, "y" : 813 } } } ] }, { "id" : 106910, "reactomeId" : 11019918, "displayName" : "Cohesin:PDS5:WAPAL:Centromere", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1374, "y" : 653 }, "minX" : 1307, "maxX" : 1448, "minY" : 629, "maxY" : 730, "prop" : { "x" : 1307, "y" : 635, "width" : 135, "height" : 36 }, "textPosition" : { "x" : 1311, "y" : 636 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1442, "y" : 635 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1442, "y" : 635 } } }, "connectors" : [ { "edgeId" : 106908, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1373, "y" : 674 }, "to" : { "x" : 1372, "y" : 730 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 106913, "reactomeId" : 11019885, "displayName" : "eco1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1299, "y" : 774 }, "minX" : 1245, "maxX" : 1364, "minY" : 757, "maxY" : 785, "prop" : { "x" : 1273, "y" : 763, "width" : 53, "height" : 22 }, "textPosition" : { "x" : 1280, "y" : 763 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1326, "y" : 763 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1326, "y" : 763 } } }, "connectors" : [ { "edgeId" : 106914, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1267, "y" : 774 }, "to" : { "x" : 1253, "y" : 774 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1249, "y" : 775 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1249, "y" : 775 } } }, { "edgeId" : 106908, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1332, "y" : 772 }, "to" : { "x" : 1356, "y" : 771 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1360, "y" : 771 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1360, "y" : 771 } } } ] }, { "id" : 106912, "reactomeId" : 11019920, "displayName" : "Ac-Cohesin:PDS5:WAPAL:Centromere", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1373, "y" : 878 }, "minX" : 1309, "maxX" : 1443, "minY" : 808, "maxY" : 896, "prop" : { "x" : 1309, "y" : 860, "width" : 128, "height" : 36 }, "textPosition" : { "x" : 1309, "y" : 861 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1437, "y" : 860 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1437, "y" : 860 } } }, "connectors" : [ { "edgeId" : 106908, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1372, "y" : 857 }, "to" : { "x" : 1372, "y" : 808 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1368, "y" : 850 }, "b" : { "x" : 1372, "y" : 857 }, "c" : { "x" : 1376, "y" : 850 }, "type" : "ARROW", "centre" : { "x" : 1376, "y" : 850 } } } ] }, { "id" : 106915, "reactomeId" : 11019872, "displayName" : "Cohesin:PDS5:WAPAL:Chromosomal Arm", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1235, "y" : 687 }, "minX" : 1164, "maxX" : 1313, "minY" : 656, "maxY" : 730, "prop" : { "x" : 1164, "y" : 662, "width" : 143, "height" : 50 }, "textPosition" : { "x" : 1164, "y" : 663 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1307, "y" : 662 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1307, "y" : 662 } } }, "connectors" : [ { "edgeId" : 106914, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1235, "y" : 715 }, "to" : { "x" : 1235, "y" : 730 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 106916, "reactomeId" : 11019880, "displayName" : "Ac-Cohesin:PDS5:WAPAL:Chromosomal Arm", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1239, "y" : 880 }, "minX" : 1193, "maxX" : 1291, "minY" : 807, "maxY" : 911, "prop" : { "x" : 1193, "y" : 850, "width" : 92, "height" : 61 }, "textPosition" : { "x" : 1194, "y" : 848 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1285, "y" : 850 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1285, "y" : 850 } } }, "connectors" : [ { "edgeId" : 106914, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1238, "y" : 847 }, "to" : { "x" : 1238, "y" : 807 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1234, "y" : 840 }, "b" : { "x" : 1238, "y" : 847 }, "c" : { "x" : 1242, "y" : 840 }, "type" : "ARROW", "centre" : { "x" : 1242, "y" : 840 } } } ] }, { "id" : 106927, "reactomeId" : 11019896, "displayName" : "Sister Chromosomal Arms:Ac-Cohesin:PDS5:CDCA5:WAPAL", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1240, "y" : 1132 }, "minX" : 1158, "maxX" : 1328, "minY" : 1101, "maxY" : 1157, "prop" : { "x" : 1158, "y" : 1107, "width" : 164, "height" : 50 }, "textPosition" : { "x" : 1163, "y" : 1108 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1322, "y" : 1107 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1322, "y" : 1107 } } }, "connectors" : [ ] }, { "id" : 106926, "reactomeId" : 10997699, "displayName" : "cdc25", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 327, "y" : 292 }, "minX" : 297, "maxX" : 363, "minY" : 275, "maxY" : 303, "prop" : { "x" : 297, "y" : 281, "width" : 60, "height" : 22 }, "textPosition" : { "x" : 304, "y" : 281 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 357, "y" : 281 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 357, "y" : 281 } } }, "connectors" : [ ] }, { "id" : 106929, "reactomeId" : 11049426, "displayName" : "Mitotic Prometaphase", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1329, "y" : 1270 }, "minX" : 1240, "maxX" : 1418, "minY" : 1246, "maxY" : 1295, "prop" : { "x" : 1240, "y" : 1246, "width" : 178, "height" : 49 }, "textPosition" : { "x" : 1252, "y" : 1256 }, "connectors" : [ ] }, { "id" : 106928, "reactomeId" : 11019948, "displayName" : "Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1376, "y" : 1063 }, "minX" : 1312, "maxX" : 1446, "minY" : 1027, "maxY" : 1094, "prop" : { "x" : 1312, "y" : 1033, "width" : 128, "height" : 61 }, "textPosition" : { "x" : 1320, "y" : 1031 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1440, "y" : 1033 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1440, "y" : 1033 } } }, "connectors" : [ ] }, { "id" : 106867, "reactomeId" : 11004603, "displayName" : "CCNA", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 388, "y" : 35 }, "minX" : 354, "maxX" : 440, "minY" : 24, "maxY" : 75, "prop" : { "x" : 354, "y" : 24, "width" : 68, "height" : 22 }, "textPosition" : { "x" : 367, "y" : 24 }, "connectors" : [ { "edgeId" : 106866, "type" : "INPUT", "segments" : [ { "from" : { "x" : 402, "y" : 52 }, "to" : { "x" : 440, "y" : 75 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 106930, "reactomeId" : 11049414, "displayName" : "Mitotic Telophase/Cytokinesis", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1310, "y" : 591 }, "minX" : 1208, "maxX" : 1412, "minY" : 569, "maxY" : 614, "prop" : { "x" : 1208, "y" : 569, "width" : 204, "height" : 45 }, "textPosition" : { "x" : 1210, "y" : 577 }, "connectors" : [ ] }, { "id" : 106869, "reactomeId" : 11004605, "displayName" : "CCNA:CDK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 440, "y" : 139 }, "minX" : 394, "maxX" : 493, "minY" : 123, "maxY" : 150, "prop" : { "x" : 394, "y" : 129, "width" : 93, "height" : 21 }, "textPosition" : { "x" : 402, "y" : 129 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 487, "y" : 129 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 487, "y" : 129 } } }, "connectors" : [ { "edgeId" : 106866, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 106870, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 106868, "reactomeId" : 10997653, "displayName" : "CDK2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 494, "y" : 37 }, "minX" : 440, "maxX" : 528, "minY" : 21, "maxY" : 75, "prop" : { "x" : 466, "y" : 27, "width" : 56, "height" : 20 }, "textPosition" : { "x" : 474, "y" : 27 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 522, "y" : 27 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 522, "y" : 27 } } }, "connectors" : [ { "edgeId" : 106866, "type" : "INPUT", "segments" : [ { "from" : { "x" : 479, "y" : 50 }, "to" : { "x" : 440, "y" : 75 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 106871, "reactomeId" : 11004709, "displayName" : "CCNA:CDK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 505, "y" : 414 }, "minX" : 379, "maxX" : 613, "minY" : 391, "maxY" : 427, "prop" : { "x" : 452, "y" : 402, "width" : 107, "height" : 25 }, "textPosition" : { "x" : 467, "y" : 406 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 559, "y" : 402 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 559, "y" : 402 } } }, "connectors" : [ { "edgeId" : 106884, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 449, "y" : 402 }, "to" : { "x" : 395, "y" : 391 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 441, "y" : 405 }, "b" : { "x" : 449, "y" : 402 }, "c" : { "x" : 443, "y" : 397 }, "type" : "ARROW", "centre" : { "x" : 443, "y" : 397 } } }, { "edgeId" : 106870, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 106888, "type" : "INPUT", "segments" : [ { "from" : { "x" : 562, "y" : 412 }, "to" : { "x" : 613, "y" : 411 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 106878, "type" : "INPUT", "segments" : [ { "from" : { "x" : 449, "y" : 419 }, "to" : { "x" : 379, "y" : 426 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 106873, "reactomeId" : 11005061, "displayName" : "Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 592, "y" : 1039 }, "minX" : 528, "maxX" : 662, "minY" : 987, "maxY" : 1085, "prop" : { "x" : 528, "y" : 993, "width" : 128, "height" : 92 }, "textPosition" : { "x" : 532, "y" : 1008 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 656, "y" : 993 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 656, "y" : 993 } } }, "connectors" : [ { "edgeId" : 106872, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 106939, "reactomeId" : 11048868, "displayName" : "Synthesis of DNA", "schemaClass" : "Pathway", "renderableClass" : "ProcessNode", "position" : { "x" : 279, "y" : 955 }, "minX" : 199, "maxX" : 360, "minY" : 921, "maxY" : 989, "prop" : { "x" : 199, "y" : 921, "width" : 161, "height" : 68 }, "textPosition" : { "x" : 218, "y" : 940 }, "connectors" : [ ] }, { "id" : 106875, "reactomeId" : 10997443, "displayName" : "CCNA:p-T160-CDK2,CCNE:p-T160-CDK2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 960, "y" : 889 }, "minX" : 763, "maxX" : 1013, "minY" : 866, "maxY" : 920, "prop" : { "x" : 908, "y" : 866, "width" : 105, "height" : 46 }, "textPosition" : { "x" : 914, "y" : 865 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 106872, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 902, "y" : 897 }, "to" : { "x" : 763, "y" : 920 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 896, "y" : 902 }, "b" : { "x" : 902, "y" : 897 }, "c" : { "x" : 895, "y" : 894 }, "type" : "ARROW", "centre" : { "x" : 895, "y" : 894 } } } ] }, { "id" : 106874, "reactomeId" : 10997110, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 667, "y" : 890 }, "minX" : 645, "maxX" : 763, "minY" : 879, "maxY" : 920, "prop" : { "x" : 645, "y" : 879, "width" : 44, "height" : 23 }, "textPosition" : { "x" : 654, "y" : 880 }, "connectors" : [ { "edgeId" : 106872, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 695, "y" : 896 }, "to" : { "x" : 763, "y" : 920 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 723, "y" : 902 }, "b" : { "x" : 735, "y" : 914 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 729, "y" : 908 } } }, "endShape" : { "a" : { "x" : 703, "y" : 895 }, "b" : { "x" : 695, "y" : 896 }, "c" : { "x" : 700, "y" : 902 }, "type" : "ARROW", "centre" : { "x" : 700, "y" : 902 } } } ] }, { "id" : 106877, "reactomeId" : 10997963, "displayName" : "26S proteasome", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 835, "y" : 1034 }, "minX" : 769, "maxX" : 902, "minY" : 986, "maxY" : 1045, "prop" : { "x" : 775, "y" : 1023, "width" : 121, "height" : 22 }, "textPosition" : { "x" : 779, "y" : 1024 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 896, "y" : 1023 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 896, "y" : 1023 } } }, "connectors" : [ { "edgeId" : 106872, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 819, "y" : 1020 }, "to" : { "x" : 776, "y" : 992 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 773, "y" : 990 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 773, "y" : 990 } } } ] }, { "id" : 106876, "reactomeId" : 11005057, "displayName" : "CUL1:SKP1:SKP2:CKS1B", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 764, "y" : 836 }, "minX" : 704, "maxX" : 831, "minY" : 812, "maxY" : 920, "prop" : { "x" : 704, "y" : 818, "width" : 121, "height" : 36 }, "textPosition" : { "x" : 708, "y" : 819 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 825, "y" : 818 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 825, "y" : 818 } } }, "connectors" : [ { "edgeId" : 106872, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 763, "y" : 857 }, "to" : { "x" : 763, "y" : 920 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 767, "y" : 864 }, "b" : { "x" : 763, "y" : 857 }, "c" : { "x" : 759, "y" : 864 }, "type" : "ARROW", "centre" : { "x" : 759, "y" : 864 } } } ] }, { "id" : 106879, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 413, "y" : 476 }, "minX" : 379, "maxX" : 434, "minY" : 426, "maxY" : 491, "prop" : { "x" : 394, "y" : 461, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 398, "y" : 465 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 428, "y" : 466 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 428, "y" : 466 } } }, "connectors" : [ { "edgeId" : 106878, "type" : "INPUT", "segments" : [ { "from" : { "x" : 402, "y" : 458 }, "to" : { "x" : 379, "y" : 426 } } ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 106898, "reactomeId" : 11001239, "displayName" : "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1790, "y" : 536 }, "minX" : 1764, "maxX" : 1944, "minY" : 528, "maxY" : 542, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1764, "y" : 536 }, "to" : { "x" : 1790, "y" : 536 } }, { "from" : { "x" : 1790, "y" : 536 }, "to" : { "x" : 1944, "y" : 528 } } ], "endShape" : { "a" : { "x" : 1937, "y" : 532 }, "b" : { "x" : 1944, "y" : 528 }, "c" : { "x" : 1937, "y" : 524 }, "type" : "ARROW", "centre" : { "x" : 1937, "y" : 524 } }, "reactionShape" : { "a" : { "x" : 1784, "y" : 530 }, "b" : { "x" : 1796, "y" : 542 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1790, "y" : 536 } }, "inputs" : [ { "id" : 106899 } ], "outputs" : [ { "id" : 106900 } ] }, { "id" : 106866, "reactomeId" : 11004607, "displayName" : "Formation of Cyclin A:Cdk2 complexes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 440, "y" : 89 }, "minX" : 434, "maxX" : 446, "minY" : 75, "maxY" : 126, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 440, "y" : 75 }, "to" : { "x" : 440, "y" : 89 } }, { "from" : { "x" : 440, "y" : 89 }, "to" : { "x" : 440, "y" : 126 } } ], "endShape" : { "a" : { "x" : 436, "y" : 119 }, "b" : { "x" : 440, "y" : 126 }, "c" : { "x" : 444, "y" : 119 }, "type" : "ARROW", "centre" : { "x" : 444, "y" : 119 } }, "reactionShape" : { "c" : { "x" : 440, "y" : 89 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 440, "y" : 89 } }, "inputs" : [ { "id" : 106867, "points" : [ { "x" : 402, "y" : 52 } ] }, { "id" : 106868, "points" : [ { "x" : 479, "y" : 50 } ] } ], "outputs" : [ { "id" : 106869 } ] }, { "id" : 106914, "reactomeId" : 11019890, "displayName" : "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1237, "y" : 775 }, "minX" : 1231, "maxX" : 1243, "minY" : 730, "maxY" : 807, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1235, "y" : 730 }, "to" : { "x" : 1237, "y" : 775 } }, { "from" : { "x" : 1237, "y" : 775 }, "to" : { "x" : 1238, "y" : 807 } } ], "reactionShape" : { "a" : { "x" : 1231, "y" : 769 }, "b" : { "x" : 1243, "y" : 781 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1237, "y" : 775 } }, "inputs" : [ { "id" : 106909, "points" : [ { "x" : 1266, "y" : 729 } ], "stoichiometry" : 2 }, { "id" : 106915, "points" : [ { "x" : 1235, "y" : 715 } ] } ], "outputs" : [ { "id" : 106911, "points" : [ { "x" : 1271, "y" : 808 } ], "stoichiometry" : 2 }, { "id" : 106916, "points" : [ { "x" : 1238, "y" : 847 } ] } ], "catalysts" : [ { "id" : 106913, "points" : [ { "x" : 1267, "y" : 774 } ] } ] }, { "id" : 106901, "reactomeId" : 11001241, "displayName" : "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1788, "y" : 479 }, "minX" : 1700, "maxX" : 1969, "minY" : 468, "maxY" : 485, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1700, "y" : 479 }, "to" : { "x" : 1788, "y" : 479 } }, { "from" : { "x" : 1788, "y" : 479 }, "to" : { "x" : 1969, "y" : 468 } } ], "endShape" : { "a" : { "x" : 1962, "y" : 472 }, "b" : { "x" : 1969, "y" : 468 }, "c" : { "x" : 1962, "y" : 464 }, "type" : "ARROW", "centre" : { "x" : 1962, "y" : 464 } }, "reactionShape" : { "a" : { "x" : 1782, "y" : 473 }, "b" : { "x" : 1794, "y" : 485 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1788, "y" : 479 } }, "inputs" : [ { "id" : 106902 } ], "outputs" : [ { "id" : 106903 } ] }, { "id" : 106884, "reactomeId" : 11004711, "displayName" : "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 328, "y" : 391 }, "minX" : 257, "maxX" : 395, "minY" : 385, "maxY" : 397, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 257, "y" : 391 }, "to" : { "x" : 328, "y" : 391 } }, { "from" : { "x" : 328, "y" : 391 }, "to" : { "x" : 395, "y" : 391 } } ], "reactionShape" : { "a" : { "x" : 322, "y" : 385 }, "b" : { "x" : 334, "y" : 397 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 328, "y" : 391 } }, "inputs" : [ { "id" : 106885, "points" : [ { "x" : 237, "y" : 378 } ] }, { "id" : 106881, "points" : [ { "x" : 202, "y" : 402 } ] } ], "outputs" : [ { "id" : 106886, "points" : [ { "x" : 415, "y" : 373 } ] }, { "id" : 106871, "points" : [ { "x" : 449, "y" : 402 } ] } ], "catalysts" : [ { "id" : 106887, "points" : [ { "x" : 327, "y" : 352 } ] } ] }, { "id" : 106870, "reactomeId" : 11004762, "displayName" : "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 467, "y" : 269 }, "minX" : 442, "maxX" : 501, "minY" : 153, "maxY" : 399, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 442, "y" : 153 }, "to" : { "x" : 467, "y" : 269 } }, { "from" : { "x" : 467, "y" : 269 }, "to" : { "x" : 501, "y" : 399 } } ], "endShape" : { "a" : { "x" : 495, "y" : 393 }, "b" : { "x" : 501, "y" : 399 }, "c" : { "x" : 503, "y" : 391 }, "type" : "ARROW", "centre" : { "x" : 503, "y" : 391 } }, "reactionShape" : { "a" : { "x" : 461, "y" : 263 }, "b" : { "x" : 473, "y" : 275 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 467, "y" : 269 } }, "inputs" : [ { "id" : 106869 } ], "outputs" : [ { "id" : 106871 } ] }, { "id" : 106872, "reactomeId" : 11005063, "displayName" : "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 763, "y" : 983 }, "minX" : 659, "maxX" : 769, "minY" : 920, "maxY" : 1018, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 659, "y" : 1018 }, "to" : { "x" : 763, "y" : 983 } }, { "from" : { "x" : 763, "y" : 983 }, "to" : { "x" : 763, "y" : 920 } } ], "reactionShape" : { "a" : { "x" : 757, "y" : 977 }, "b" : { "x" : 769, "y" : 989 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 763, "y" : 983 } }, "inputs" : [ { "id" : 106873 } ], "outputs" : [ { "id" : 106874, "points" : [ { "x" : 695, "y" : 896 } ], "stoichiometry" : 3 }, { "id" : 106875, "points" : [ { "x" : 902, "y" : 897 } ] }, { "id" : 106876, "points" : [ { "x" : 763, "y" : 857 } ] } ], "catalysts" : [ { "id" : 106877, "points" : [ { "x" : 819, "y" : 1020 } ] } ] }, { "id" : 106904, "reactomeId" : 11001245, "displayName" : "Proteasome mediated degradation of Cyclin D1", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2031, "y" : 273 }, "minX" : 2009, "maxX" : 2115, "minY" : 267, "maxY" : 279, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2009, "y" : 275 }, "to" : { "x" : 2031, "y" : 273 } }, { "from" : { "x" : 2031, "y" : 273 }, "to" : { "x" : 2115, "y" : 276 } } ], "endShape" : { "a" : { "x" : 2108, "y" : 280 }, "b" : { "x" : 2115, "y" : 276 }, "c" : { "x" : 2108, "y" : 272 }, "type" : "ARROW", "centre" : { "x" : 2108, "y" : 272 } }, "reactionShape" : { "a" : { "x" : 2025, "y" : 267 }, "b" : { "x" : 2037, "y" : 279 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2031, "y" : 273 } }, "inputs" : [ { "id" : 106905 } ], "outputs" : [ { "id" : 106906, "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 106907, "points" : [ { "x" : 2113, "y" : 139 }, { "x" : 2030, "y" : 190 } ] } ] }, { "id" : 106888, "reactomeId" : 11005083, "displayName" : "CAK-mediated phosphorylation of Cyclin A:Cdk2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 649, "y" : 411 }, "minX" : 613, "maxX" : 683, "minY" : 405, "maxY" : 417, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 613, "y" : 411 }, "to" : { "x" : 649, "y" : 411 } }, { "from" : { "x" : 649, "y" : 411 }, "to" : { "x" : 683, "y" : 411 } } ], "reactionShape" : { "a" : { "x" : 643, "y" : 405 }, "b" : { "x" : 655, "y" : 417 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 649, "y" : 411 } }, "inputs" : [ { "id" : 106889, "points" : [ { "x" : 602, "y" : 432 } ] }, { "id" : 106871, "points" : [ { "x" : 562, "y" : 412 } ] } ], "outputs" : [ { "id" : 106890, "points" : [ { "x" : 722, "y" : 382 } ] }, { "id" : 106891, "points" : [ { "x" : 696, "y" : 431 } ] } ], "catalysts" : [ { "id" : 106892, "points" : [ { "x" : 649, "y" : 355 } ] } ] }, { "id" : 106893, "reactomeId" : 11005080, "displayName" : "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1121, "y" : 529 }, "minX" : 1041, "maxX" : 1186, "minY" : 512, "maxY" : 548, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1041, "y" : 548 }, "to" : { "x" : 1121, "y" : 529 } }, { "from" : { "x" : 1121, "y" : 529 }, "to" : { "x" : 1186, "y" : 512 } } ], "reactionShape" : { "a" : { "x" : 1115, "y" : 523 }, "b" : { "x" : 1127, "y" : 535 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1121, "y" : 529 } }, "inputs" : [ { "id" : 106894, "points" : [ { "x" : 1042, "y" : 611 } ] }, { "id" : 106895, "points" : [ { "x" : 999, "y" : 549 } ] } ], "outputs" : [ { "id" : 106896, "points" : [ { "x" : 1252, "y" : 495 } ] }, { "id" : 106897, "points" : [ { "x" : 1160, "y" : 470 } ] } ], "catalysts" : [ { "id" : 106890, "points" : [ { "x" : 760, "y" : 382 } ] } ] }, { "id" : 106908, "reactomeId" : 11019922, "displayName" : "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1372, "y" : 771 }, "minX" : 1366, "maxX" : 1378, "minY" : 730, "maxY" : 808, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1372, "y" : 730 }, "to" : { "x" : 1372, "y" : 771 } }, { "from" : { "x" : 1372, "y" : 771 }, "to" : { "x" : 1372, "y" : 808 } } ], "reactionShape" : { "a" : { "x" : 1366, "y" : 765 }, "b" : { "x" : 1378, "y" : 777 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1372, "y" : 771 } }, "inputs" : [ { "id" : 106909, "points" : [ { "x" : 1341, "y" : 729 } ], "stoichiometry" : 2 }, { "id" : 106910, "points" : [ { "x" : 1373, "y" : 674 } ] } ], "outputs" : [ { "id" : 106911, "points" : [ { "x" : 1340, "y" : 809 } ], "stoichiometry" : 2 }, { "id" : 106912, "points" : [ { "x" : 1372, "y" : 857 } ] } ], "catalysts" : [ { "id" : 106913, "points" : [ { "x" : 1332, "y" : 772 } ] } ] }, { "id" : 106878, "reactomeId" : 11004744, "displayName" : "Phosphorylation of Cyclin A:Cdk2 at Tyr 15", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 336, "y" : 426 }, "minX" : 271, "maxX" : 379, "minY" : 420, "maxY" : 432, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 379, "y" : 426 }, "to" : { "x" : 336, "y" : 426 } }, { "from" : { "x" : 336, "y" : 426 }, "to" : { "x" : 271, "y" : 426 } } ], "reactionShape" : { "a" : { "x" : 330, "y" : 420 }, "b" : { "x" : 342, "y" : 432 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 336, "y" : 426 } }, "inputs" : [ { "id" : 106879, "points" : [ { "x" : 402, "y" : 458 } ] }, { "id" : 106871, "points" : [ { "x" : 449, "y" : 419 } ] } ], "outputs" : [ { "id" : 106880, "points" : [ { "x" : 255, "y" : 452 } ] }, { "id" : 106881, "points" : [ { "x" : 215, "y" : 422 } ] } ], "catalysts" : [ { "id" : 106882, "points" : [ { "x" : 336, "y" : 463 } ] } ], "activators" : [ { "id" : 106883, "points" : [ { "x" : 282, "y" : 487 } ] } ] } ], "compartments" : [ { "id" : 106933, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1171, "y" : 738 }, "minX" : 0, "maxX" : 2342, "minY" : 0, "maxY" : 1476, "prop" : { "x" : 0, "y" : 0, "width" : 2342, "height" : 1476 }, "textPosition" : { "x" : 48, "y" : 69 }, "insets" : { "x" : 10, "y" : 10, "width" : 2322, "height" : 1456 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 106867, 106868, 106869, 106866, 106917, 106906, 106907, 106900, 106903, 106905, 106904, 106950, 106951 ] }, { "id" : 106917, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 943, "y" : 783 }, "minX" : 36, "maxX" : 1851, "minY" : 187, "maxY" : 1379, "prop" : { "x" : 36, "y" : 187, "width" : 1815, "height" : 1192 }, "textPosition" : { "x" : 136, "y" : 1297 }, "insets" : { "x" : 46, "y" : 197, "width" : 1795, "height" : 1172 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 106870, 106871, 106876, 106874, 106873, 106872, 106877, 106878, 106879, 106880, 106881, 106882, 106884, 106885, 106886, 106887, 106888, 106889, 106890, 106891, 106892, 106893, 106897, 106899, 106898, 106902, 106901, 106926, 106944, 106942, 106943, 106913, 106927, 106928, 106916, 106908, 106912, 106930, 106909, 106911, 106910, 106947, 106914, 106915, 106948, 106895, 106894, 106896, 106875, 106949, 106939, 106883, 106929 ] } ], "notes" : [ ], "links" : [ { "id" : 106945, "renderableClass" : "Interaction", "position" : { "x" : 1284, "y" : 1201 }, "minX" : 1256, "maxX" : 1312, "minY" : 1160, "maxY" : 1243, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1256, "y" : 1160 }, "to" : { "x" : 1312, "y" : 1243 } } ], "endShape" : { "a" : { "x" : 1305, "y" : 1239 }, "b" : { "x" : 1312, "y" : 1243 }, "c" : { "x" : 1311, "y" : 1235 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1311, "y" : 1235 } }, "reactionShape" : { "a" : { "x" : 1278, "y" : 1195 }, "b" : { "x" : 1290, "y" : 1207 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1284, "y" : 1201 } }, "inputs" : [ { "id" : 106927 } ], "outputs" : [ { "id" : 106929 } ] }, { "id" : 106944, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 327, "y" : 312 }, "minX" : 321, "maxX" : 333, "minY" : 306, "maxY" : 318, "segments" : [ { "from" : { "x" : 327, "y" : 306 }, "to" : { "x" : 327, "y" : 318 } } ], "reactionShape" : { "a" : { "x" : 321, "y" : 306 }, "b" : { "x" : 333, "y" : 318 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 327, "y" : 312 } }, "inputs" : [ { "id" : 106926 } ], "outputs" : [ { "id" : 106887 } ] }, { "id" : 106947, "renderableClass" : "Interaction", "position" : { "x" : 1343, "y" : 624 }, "minX" : 1333, "maxX" : 1353, "minY" : 617, "maxY" : 632, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1333, "y" : 617 }, "to" : { "x" : 1353, "y" : 632 } } ], "endShape" : { "a" : { "x" : 1345, "y" : 631 }, "b" : { "x" : 1353, "y" : 632 }, "c" : { "x" : 1350, "y" : 625 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1350, "y" : 625 } }, "reactionShape" : { "a" : { "x" : 1337, "y" : 618 }, "b" : { "x" : 1349, "y" : 630 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1343, "y" : 624 } }, "inputs" : [ { "id" : 106930 } ], "outputs" : [ { "id" : 106910 } ] }, { "id" : 106946, "renderableClass" : "Interaction", "position" : { "x" : 1351, "y" : 1170 }, "minX" : 1334, "maxX" : 1368, "minY" : 1097, "maxY" : 1243, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1368, "y" : 1097 }, "to" : { "x" : 1334, "y" : 1243 } } ], "endShape" : { "a" : { "x" : 1332, "y" : 1235 }, "b" : { "x" : 1334, "y" : 1243 }, "c" : { "x" : 1339, "y" : 1237 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1339, "y" : 1237 } }, "reactionShape" : { "a" : { "x" : 1345, "y" : 1164 }, "b" : { "x" : 1357, "y" : 1176 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1351, "y" : 1170 } }, "inputs" : [ { "id" : 106928 } ], "outputs" : [ { "id" : 106929 } ] }, { "id" : 106949, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 844, "y" : 621 }, "minX" : 739, "maxX" : 949, "minY" : 382, "maxY" : 860, "segments" : [ { "from" : { "x" : 739, "y" : 382 }, "to" : { "x" : 949, "y" : 860 } } ], "reactionShape" : { "a" : { "x" : 838, "y" : 615 }, "b" : { "x" : 850, "y" : 627 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 844, "y" : 621 } }, "inputs" : [ { "id" : 106890 } ], "outputs" : [ { "id" : 106875 } ] }, { "id" : 106948, "renderableClass" : "Interaction", "position" : { "x" : 1273, "y" : 638 }, "minX" : 1255, "maxX" : 1291, "minY" : 617, "maxY" : 659, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1291, "y" : 617 }, "to" : { "x" : 1255, "y" : 659 } } ], "endShape" : { "a" : { "x" : 1256, "y" : 651 }, "b" : { "x" : 1255, "y" : 659 }, "c" : { "x" : 1263, "y" : 656 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1263, "y" : 656 } }, "reactionShape" : { "a" : { "x" : 1267, "y" : 632 }, "b" : { "x" : 1279, "y" : 644 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1273, "y" : 638 } }, "inputs" : [ { "id" : 106930 } ], "outputs" : [ { "id" : 106915 } ] } ], "shadows" : [ { "id" : 106951, "reactomeId" : 11049504, "displayName" : "Cyclin A:Cdk2-associated events at S phase entry", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 736, "y" : 554 }, "minX" : 73, "maxX" : 1400, "minY" : 14, "maxY" : 1095, "prop" : { "x" : 73, "y" : 14, "width" : 1327, "height" : 611 }, "points" : [ { "x" : 73, "y" : 14 }, { "x" : 1400, "y" : 14 }, { "x" : 1400, "y" : 1095 }, { "x" : 73, "y" : 1095 } ], "colour" : "#dc3912" }, { "id" : 106950, "reactomeId" : 11049138, "displayName" : "Ubiquitin-dependent degradation of Cyclin D", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1890, "y" : 334 }, "minX" : 1574, "maxX" : 2207, "minY" : 104, "maxY" : 564, "prop" : { "x" : 1574, "y" : 104, "width" : 633, "height" : 460 }, "points" : [ { "x" : 1574, "y" : 104 }, { "x" : 2207, "y" : 104 }, { "x" : 2207, "y" : 564 }, { "x" : 1574, "y" : 564 } ], "colour" : "#4684ee" }, { "id" : 106952, "reactomeId" : 11050332, "displayName" : "Establishment of Sister Chromatid Cohesion", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1303, "y" : 773 }, "minX" : 1154, "maxX" : 1452, "minY" : 625, "maxY" : 921, "prop" : { "x" : 1154, "y" : 625, "width" : 298, "height" : 296 }, "points" : [ { "x" : 1154, "y" : 625 }, { "x" : 1452, "y" : 625 }, { "x" : 1452, "y" : 921 }, { "x" : 1154, "y" : 921 } ], "colour" : "#008000" } ], "minX" : 0, "maxX" : 2342, "minY" : 0, "maxY" : 1476, "disease" : false }