{ "dbId" : 10993629, "stableId" : "R-CEL-74182", "displayName" : "Ketone body metabolism", "nodes" : [ { "id" : 38819, "reactomeId" : 113559, "displayName" : "Ac-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 231, "y" : 294 }, "minX" : 181, "maxX" : 405, "minY" : 197, "maxY" : 342, "prop" : { "x" : 197, "y" : 279, "width" : 68, "height" : 30 }, "textPosition" : { "x" : 205, "y" : 283 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 260, "y" : 284 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 260, "y" : 284 } } }, "connectors" : [ { "edgeId" : 38818, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 262, "y" : 241 }, "b" : { "x" : 274, "y" : 253 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 268, "y" : 247 } } } }, { "edgeId" : 38834, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 181, "y" : 245 }, "b" : { "x" : 193, "y" : 257 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 187, "y" : 251 } } } }, { "edgeId" : 38823, "type" : "INPUT", "segments" : [ { "from" : { "x" : 248, "y" : 276 }, "to" : { "x" : 344, "y" : 197 } }, { "from" : { "x" : 344, "y" : 197 }, "to" : { "x" : 402, "y" : 198 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38827, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 268, "y" : 304 }, "to" : { "x" : 389, "y" : 342 } }, { "from" : { "x" : 389, "y" : 342 }, "to" : { "x" : 405, "y" : 341 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 276, "y" : 302 }, "b" : { "x" : 268, "y" : 304 }, "c" : { "x" : 273, "y" : 310 }, "type" : "ARROW", "centre" : { "x" : 273, "y" : 310 } } } ] }, { "id" : 38820, "reactomeId" : 73871, "displayName" : "ACA-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 293, "y" : 128 }, "minX" : 158, "maxX" : 500, "minY" : 112, "maxY" : 253, "prop" : { "x" : 255, "y" : 113, "width" : 77, "height" : 30 }, "textPosition" : { "x" : 263, "y" : 117 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 327, "y" : 118 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 327, "y" : 118 } } }, "connectors" : [ { "edgeId" : 38818, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 292, "y" : 146 }, "to" : { "x" : 292, "y" : 175 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 296, "y" : 153 }, "b" : { "x" : 292, "y" : 146 }, "c" : { "x" : 288, "y" : 153 }, "type" : "ARROW", "centre" : { "x" : 288, "y" : 153 } } }, { "edgeId" : 38834, "type" : "INPUT", "segments" : [ { "from" : { "x" : 252, "y" : 137 }, "to" : { "x" : 158, "y" : 160 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38823, "type" : "INPUT", "segments" : [ { "from" : { "x" : 324, "y" : 146 }, "to" : { "x" : 402, "y" : 180 } }, { "from" : { "x" : 402, "y" : 180 }, "to" : { "x" : 402, "y" : 198 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38830, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 335, "y" : 135 }, "to" : { "x" : 500, "y" : 171 } }, { "from" : { "x" : 500, "y" : 171 }, "to" : { "x" : 500, "y" : 253 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 343, "y" : 133 }, "b" : { "x" : 335, "y" : 135 }, "c" : { "x" : 341, "y" : 140 }, "type" : "ARROW", "centre" : { "x" : 341, "y" : 140 } } } ] }, { "id" : 38821, "reactomeId" : 29374, "displayName" : "CoA-SH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 158, "y" : 124 }, "minX" : 124, "maxX" : 292, "minY" : 108, "maxY" : 175, "prop" : { "x" : 124, "y" : 109, "width" : 68, "height" : 30 }, "textPosition" : { "x" : 131, "y" : 113 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 187, "y" : 114 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 187, "y" : 114 } } }, "connectors" : [ { "edgeId" : 38818, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 195, "y" : 136 }, "to" : { "x" : 292, "y" : 175 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 203, "y" : 135 }, "b" : { "x" : 195, "y" : 136 }, "c" : { "x" : 200, "y" : 142 }, "type" : "ARROW", "centre" : { "x" : 200, "y" : 142 } } }, { "edgeId" : 38834, "type" : "INPUT", "segments" : [ { "from" : { "x" : 158, "y" : 142 }, "to" : { "x" : 158, "y" : 160 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38822, "reactomeId" : 10915971, "displayName" : "ACAT1 tetramer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 224, "y" : 199 }, "minX" : 166, "maxX" : 285, "minY" : 174, "maxY" : 219, "prop" : { "x" : 192, "y" : 180, "width" : 65, "height" : 39 }, "textPosition" : { "x" : 193, "y" : 184 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 257, "y" : 180 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 257, "y" : 180 } } }, "connectors" : [ { "edgeId" : 38818, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 260, "y" : 198 }, "to" : { "x" : 277, "y" : 198 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 281, "y" : 198 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 281, "y" : 198 } } }, { "edgeId" : 38834, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 189, "y" : 199 }, "to" : { "x" : 174, "y" : 199 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 170, "y" : 200 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 170, "y" : 200 } } } ] }, { "id" : 38824, "reactomeId" : 73917, "displayName" : "HMG CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 405, "y" : 284 }, "minX" : 371, "maxX" : 440, "minY" : 252, "maxY" : 299, "prop" : { "x" : 371, "y" : 269, "width" : 68, "height" : 30 }, "textPosition" : { "x" : 373, "y" : 273 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 434, "y" : 274 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 434, "y" : 274 } } }, "connectors" : [ { "edgeId" : 38823, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 404, "y" : 266 }, "to" : { "x" : 403, "y" : 252 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 400, "y" : 259 }, "b" : { "x" : 404, "y" : 266 }, "c" : { "x" : 407, "y" : 259 }, "type" : "ARROW", "centre" : { "x" : 407, "y" : 259 } } }, { "edgeId" : 38827, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38825, "reactomeId" : 29374, "displayName" : "CoA-SH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 447, "y" : 222 }, "minX" : 403, "maxX" : 482, "minY" : 206, "maxY" : 252, "prop" : { "x" : 413, "y" : 207, "width" : 68, "height" : 30 }, "textPosition" : { "x" : 420, "y" : 211 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 476, "y" : 212 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 476, "y" : 212 } } }, "connectors" : [ { "edgeId" : 38823, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 425, "y" : 240 }, "to" : { "x" : 403, "y" : 252 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 421, "y" : 247 }, "b" : { "x" : 425, "y" : 240 }, "c" : { "x" : 417, "y" : 240 }, "type" : "ARROW", "centre" : { "x" : 417, "y" : 240 } } } ] }, { "id" : 38826, "reactomeId" : 10918252, "displayName" : "HMGCS2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 347, "y" : 236 }, "minX" : 317, "maxX" : 395, "minY" : 219, "maxY" : 247, "prop" : { "x" : 317, "y" : 225, "width" : 60, "height" : 22 }, "textPosition" : { "x" : 317, "y" : 225 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 377, "y" : 225 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 377, "y" : 225 } } }, "connectors" : [ { "edgeId" : 38823, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 380, "y" : 236 }, "to" : { "x" : 387, "y" : 236 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 391, "y" : 236 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 391, "y" : 236 } } } ] }, { "id" : 38828, "reactomeId" : 73909, "displayName" : "ACA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 407, "y" : 377 }, "minX" : 386, "maxX" : 500, "minY" : 340, "maxY" : 392, "prop" : { "x" : 386, "y" : 362, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 391, "y" : 366 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 423, "y" : 367 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 423, "y" : 367 } } }, "connectors" : [ { "edgeId" : 38827, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 406, "y" : 359 }, "to" : { "x" : 405, "y" : 341 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 402, "y" : 352 }, "b" : { "x" : 406, "y" : 359 }, "c" : { "x" : 410, "y" : 352 }, "type" : "ARROW", "centre" : { "x" : 410, "y" : 352 } } }, { "edgeId" : 38830, "type" : "INPUT", "segments" : [ { "from" : { "x" : 431, "y" : 368 }, "to" : { "x" : 500, "y" : 340 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38829, "reactomeId" : 10918443, "displayName" : "HMGCL dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 461, "y" : 320 }, "minX" : 413, "maxX" : 499, "minY" : 297, "maxY" : 337, "prop" : { "x" : 430, "y" : 303, "width" : 63, "height" : 34 }, "textPosition" : { "x" : 434, "y" : 302 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 493, "y" : 303 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 493, "y" : 303 } } }, "connectors" : [ { "edgeId" : 38827, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 427, "y" : 320 }, "to" : { "x" : 421, "y" : 320 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 417, "y" : 320 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 417, "y" : 320 } } } ] }, { "id" : 38831, "reactomeId" : 70958, "displayName" : "SUCC-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 589, "y" : 359 }, "minX" : 500, "maxX" : 633, "minY" : 340, "maxY" : 374, "prop" : { "x" : 547, "y" : 344, "width" : 85, "height" : 30 }, "textPosition" : { "x" : 555, "y" : 348 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 627, "y" : 349 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 627, "y" : 349 } } }, "connectors" : [ { "edgeId" : 38830, "type" : "INPUT", "segments" : [ { "from" : { "x" : 544, "y" : 349 }, "to" : { "x" : 500, "y" : 340 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38832, "reactomeId" : 113536, "displayName" : "SUCCA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 581, "y" : 235 }, "minX" : 500, "maxX" : 612, "minY" : 219, "maxY" : 253, "prop" : { "x" : 551, "y" : 220, "width" : 60, "height" : 30 }, "textPosition" : { "x" : 556, "y" : 224 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 606, "y" : 225 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 606, "y" : 225 } } }, "connectors" : [ { "edgeId" : 38830, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 548, "y" : 241 }, "to" : { "x" : 500, "y" : 253 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 542, "y" : 247 }, "b" : { "x" : 548, "y" : 241 }, "c" : { "x" : 540, "y" : 239 }, "type" : "ARROW", "centre" : { "x" : 540, "y" : 239 } } } ] }, { "id" : 38833, "reactomeId" : 10918433, "displayName" : "OXCT dimers", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 587, "y" : 288 }, "minX" : 509, "maxX" : 630, "minY" : 277, "maxY" : 299, "prop" : { "x" : 544, "y" : 277, "width" : 86, "height" : 22 }, "textPosition" : { "x" : 544, "y" : 277 }, "connectors" : [ { "edgeId" : 38830, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 538, "y" : 289 }, "to" : { "x" : 517, "y" : 290 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 513, "y" : 290 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 513, "y" : 290 } } } ] }, { "id" : 38836, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1022, "y" : 199 }, "minX" : 1001, "maxX" : 1053, "minY" : 169, "maxY" : 214, "prop" : { "x" : 1001, "y" : 184, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 1006, "y" : 188 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1038, "y" : 189 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1038, "y" : 189 } } }, "connectors" : [ { "edgeId" : 38835, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1037, "y" : 181 }, "to" : { "x" : 1053, "y" : 169 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38837, "reactomeId" : 29666, "displayName" : "ACA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 984, "y" : 170 }, "minX" : 963, "maxX" : 1053, "minY" : 154, "maxY" : 262, "prop" : { "x" : 963, "y" : 155, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 968, "y" : 159 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1000, "y" : 160 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1000, "y" : 160 } } }, "connectors" : [ { "edgeId" : 38835, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1008, "y" : 169 }, "to" : { "x" : 1053, "y" : 169 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38843, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 983, "y" : 188 }, "to" : { "x" : 983, "y" : 262 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 987, "y" : 195 }, "b" : { "x" : 983, "y" : 188 }, "c" : { "x" : 979, "y" : 195 }, "type" : "ARROW", "centre" : { "x" : 979, "y" : 195 } } } ] }, { "id" : 38838, "reactomeId" : 76194, "displayName" : "CoA-SH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1001, "y" : 128 }, "minX" : 967, "maxX" : 1053, "minY" : 112, "maxY" : 169, "prop" : { "x" : 967, "y" : 113, "width" : 68, "height" : 30 }, "textPosition" : { "x" : 974, "y" : 117 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1030, "y" : 118 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1030, "y" : 118 } } }, "connectors" : [ { "edgeId" : 38835, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1020, "y" : 146 }, "to" : { "x" : 1053, "y" : 169 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38839, "reactomeId" : 191293, "displayName" : "ACA-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1231, "y" : 170 }, "minX" : 1121, "maxX" : 1271, "minY" : 154, "maxY" : 185, "prop" : { "x" : 1193, "y" : 155, "width" : 77, "height" : 30 }, "textPosition" : { "x" : 1201, "y" : 159 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1265, "y" : 160 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1265, "y" : 160 } } }, "connectors" : [ { "edgeId" : 38835, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1190, "y" : 169 }, "to" : { "x" : 1121, "y" : 169 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1183, "y" : 173 }, "b" : { "x" : 1190, "y" : 169 }, "c" : { "x" : 1183, "y" : 165 }, "type" : "ARROW", "centre" : { "x" : 1183, "y" : 165 } } } ] }, { "id" : 38840, "reactomeId" : 111294, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1168, "y" : 137 }, "minX" : 1121, "maxX" : 1186, "minY" : 121, "maxY" : 169, "prop" : { "x" : 1151, "y" : 122, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 1154, "y" : 126 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1180, "y" : 127 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1180, "y" : 127 } } }, "connectors" : [ { "edgeId" : 38835, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1148, "y" : 148 }, "to" : { "x" : 1121, "y" : 169 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1145, "y" : 155 }, "b" : { "x" : 1148, "y" : 148 }, "c" : { "x" : 1140, "y" : 149 }, "type" : "ARROW", "centre" : { "x" : 1140, "y" : 149 } } } ] }, { "id" : 38841, "reactomeId" : 76577, "displayName" : "AMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1173, "y" : 201 }, "minX" : 1121, "maxX" : 1195, "minY" : 169, "maxY" : 216, "prop" : { "x" : 1152, "y" : 186, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 1156, "y" : 190 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1189, "y" : 191 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1189, "y" : 191 } } }, "connectors" : [ { "edgeId" : 38835, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1149, "y" : 188 }, "to" : { "x" : 1121, "y" : 169 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1141, "y" : 187 }, "b" : { "x" : 1149, "y" : 188 }, "c" : { "x" : 1146, "y" : 181 }, "type" : "ARROW", "centre" : { "x" : 1146, "y" : 181 } } } ] }, { "id" : 38842, "reactomeId" : 10971515, "displayName" : "sur-5", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1081, "y" : 125 }, "minX" : 1060, "maxX" : 1109, "minY" : 108, "maxY" : 161, "prop" : { "x" : 1060, "y" : 114, "width" : 43, "height" : 22 }, "textPosition" : { "x" : 1061, "y" : 114 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1103, "y" : 114 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1103, "y" : 114 } } }, "connectors" : [ { "edgeId" : 38835, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1082, "y" : 139 }, "to" : { "x" : 1083, "y" : 153 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1084, "y" : 157 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1084, "y" : 157 } } } ] }, { "id" : 38844, "reactomeId" : 191374, "displayName" : "bHMG-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 827, "y" : 262 }, "minX" : 785, "maxX" : 871, "minY" : 246, "maxY" : 277, "prop" : { "x" : 785, "y" : 247, "width" : 85, "height" : 30 }, "textPosition" : { "x" : 791, "y" : 251 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 865, "y" : 252 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 865, "y" : 252 } } }, "connectors" : [ { "edgeId" : 38843, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38845, "reactomeId" : 76183, "displayName" : "Ac-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1063, "y" : 262 }, "minX" : 983, "maxX" : 1098, "minY" : 246, "maxY" : 277, "prop" : { "x" : 1029, "y" : 247, "width" : 68, "height" : 30 }, "textPosition" : { "x" : 1037, "y" : 251 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1092, "y" : 252 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1092, "y" : 252 } } }, "connectors" : [ { "edgeId" : 38843, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1026, "y" : 262 }, "to" : { "x" : 983, "y" : 262 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1019, "y" : 266 }, "b" : { "x" : 1026, "y" : 262 }, "c" : { "x" : 1019, "y" : 258 }, "type" : "ARROW", "centre" : { "x" : 1019, "y" : 258 } } } ] }, { "id" : 38846, "reactomeId" : 10972622, "displayName" : "HMGCLL1:Mg2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 916, "y" : 313 }, "minX" : 864, "maxX" : 975, "minY" : 270, "maxY" : 324, "prop" : { "x" : 864, "y" : 302, "width" : 105, "height" : 22 }, "textPosition" : { "x" : 864, "y" : 303 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 969, "y" : 302 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 969, "y" : 302 } } }, "connectors" : [ { "edgeId" : 38843, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 915, "y" : 299 }, "to" : { "x" : 914, "y" : 278 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 914, "y" : 274 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 914, "y" : 274 } } } ] } ], "edges" : [ { "id" : 38818, "reactomeId" : 10918247, "displayName" : "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 293, "y" : 198 }, "minX" : 243, "maxX" : 299, "minY" : 175, "maxY" : 276, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 243, "y" : 276 }, "to" : { "x" : 293, "y" : 218 } }, { "from" : { "x" : 293, "y" : 218 }, "to" : { "x" : 293, "y" : 198 } }, { "from" : { "x" : 293, "y" : 198 }, "to" : { "x" : 292, "y" : 175 } } ], "reactionShape" : { "a" : { "x" : 287, "y" : 192 }, "b" : { "x" : 299, "y" : 204 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 293, "y" : 198 } }, "inputs" : [ { "id" : 38819, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 38820, "points" : [ { "x" : 292, "y" : 146 } ] }, { "id" : 38821, "points" : [ { "x" : 195, "y" : 136 } ] } ], "catalysts" : [ { "id" : 38822, "points" : [ { "x" : 260, "y" : 198 } ] } ] }, { "id" : 38834, "reactomeId" : 10918448, "displayName" : "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 158, "y" : 200 }, "minX" : 152, "maxX" : 215, "minY" : 160, "maxY" : 276, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 158, "y" : 160 }, "to" : { "x" : 158, "y" : 200 } }, { "from" : { "x" : 158, "y" : 200 }, "to" : { "x" : 159, "y" : 226 } }, { "from" : { "x" : 159, "y" : 226 }, "to" : { "x" : 215, "y" : 276 } } ], "endShape" : { "a" : { "x" : 207, "y" : 274 }, "b" : { "x" : 215, "y" : 276 }, "c" : { "x" : 212, "y" : 268 }, "type" : "ARROW", "centre" : { "x" : 212, "y" : 268 } }, "reactionShape" : { "a" : { "x" : 152, "y" : 194 }, "b" : { "x" : 164, "y" : 206 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 158, "y" : 200 } }, "inputs" : [ { "id" : 38820, "points" : [ { "x" : 252, "y" : 137 } ] }, { "id" : 38821, "points" : [ { "x" : 158, "y" : 142 } ] } ], "outputs" : [ { "id" : 38819, "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 38822, "points" : [ { "x" : 189, "y" : 199 } ] } ] }, { "id" : 38835, "reactomeId" : 10971518, "displayName" : "AACS ligates CoA-SH to ACA, forming ACA-CoA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1085, "y" : 169 }, "minX" : 1053, "maxX" : 1121, "minY" : 163, "maxY" : 175, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1053, "y" : 169 }, "to" : { "x" : 1085, "y" : 169 } }, { "from" : { "x" : 1085, "y" : 169 }, "to" : { "x" : 1121, "y" : 169 } } ], "reactionShape" : { "a" : { "x" : 1079, "y" : 163 }, "b" : { "x" : 1091, "y" : 175 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1085, "y" : 169 } }, "inputs" : [ { "id" : 38836, "points" : [ { "x" : 1037, "y" : 181 } ] }, { "id" : 38837, "points" : [ { "x" : 1008, "y" : 169 } ] }, { "id" : 38838, "points" : [ { "x" : 1020, "y" : 146 } ] } ], "outputs" : [ { "id" : 38839, "points" : [ { "x" : 1190, "y" : 169 } ] }, { "id" : 38840, "points" : [ { "x" : 1148, "y" : 148 } ] }, { "id" : 38841, "points" : [ { "x" : 1149, "y" : 188 } ] } ], "catalysts" : [ { "id" : 38842, "points" : [ { "x" : 1082, "y" : 139 } ] } ] }, { "id" : 38823, "reactomeId" : 10918255, "displayName" : "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 403, "y" : 237 }, "minX" : 397, "maxX" : 409, "minY" : 198, "maxY" : 252, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 402, "y" : 198 }, "to" : { "x" : 403, "y" : 237 } }, { "from" : { "x" : 403, "y" : 237 }, "to" : { "x" : 403, "y" : 252 } } ], "reactionShape" : { "a" : { "x" : 397, "y" : 231 }, "b" : { "x" : 409, "y" : 243 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 403, "y" : 237 } }, "inputs" : [ { "id" : 38820, "points" : [ { "x" : 324, "y" : 146 }, { "x" : 402, "y" : 180 } ] }, { "id" : 38819, "points" : [ { "x" : 248, "y" : 276 }, { "x" : 344, "y" : 197 } ] } ], "outputs" : [ { "id" : 38824, "points" : [ { "x" : 404, "y" : 266 } ] }, { "id" : 38825, "points" : [ { "x" : 425, "y" : 240 } ] } ], "catalysts" : [ { "id" : 38826, "points" : [ { "x" : 380, "y" : 236 } ] } ] }, { "id" : 38843, "reactomeId" : 10972625, "displayName" : "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 914, "y" : 262 }, "minX" : 873, "maxX" : 983, "minY" : 256, "maxY" : 268, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 873, "y" : 262 }, "to" : { "x" : 914, "y" : 262 } }, { "from" : { "x" : 914, "y" : 262 }, "to" : { "x" : 983, "y" : 262 } } ], "reactionShape" : { "a" : { "x" : 908, "y" : 256 }, "b" : { "x" : 920, "y" : 268 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 914, "y" : 262 } }, "inputs" : [ { "id" : 38844 } ], "outputs" : [ { "id" : 38837, "points" : [ { "x" : 983, "y" : 188 } ] }, { "id" : 38845, "points" : [ { "x" : 1026, "y" : 262 } ] } ], "catalysts" : [ { "id" : 38846, "points" : [ { "x" : 915, "y" : 299 } ] } ] }, { "id" : 38827, "reactomeId" : 10918446, "displayName" : "HMG CoA => acetoacetic acid + acetyl CoA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 405, "y" : 321 }, "minX" : 399, "maxX" : 411, "minY" : 302, "maxY" : 341, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 405, "y" : 302 }, "to" : { "x" : 405, "y" : 321 } }, { "from" : { "x" : 405, "y" : 321 }, "to" : { "x" : 405, "y" : 341 } } ], "reactionShape" : { "a" : { "x" : 399, "y" : 315 }, "b" : { "x" : 411, "y" : 327 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 405, "y" : 321 } }, "inputs" : [ { "id" : 38824 } ], "outputs" : [ { "id" : 38828, "points" : [ { "x" : 406, "y" : 359 } ] }, { "id" : 38819, "points" : [ { "x" : 268, "y" : 304 }, { "x" : 389, "y" : 342 } ] } ], "catalysts" : [ { "id" : 38829, "points" : [ { "x" : 427, "y" : 320 } ] } ] }, { "id" : 38830, "reactomeId" : 10918436, "displayName" : "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 501, "y" : 290 }, "minX" : 495, "maxX" : 507, "minY" : 253, "maxY" : 340, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 500, "y" : 340 }, "to" : { "x" : 501, "y" : 290 } }, { "from" : { "x" : 501, "y" : 290 }, "to" : { "x" : 500, "y" : 253 } } ], "reactionShape" : { "a" : { "x" : 495, "y" : 284 }, "b" : { "x" : 507, "y" : 296 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 501, "y" : 290 } }, "inputs" : [ { "id" : 38831, "points" : [ { "x" : 544, "y" : 349 } ] }, { "id" : 38828, "points" : [ { "x" : 431, "y" : 368 } ] } ], "outputs" : [ { "id" : 38832, "points" : [ { "x" : 548, "y" : 241 } ] }, { "id" : 38820, "points" : [ { "x" : 335, "y" : 135 }, { "x" : 500, "y" : 171 } ] } ], "catalysts" : [ { "id" : 38833, "points" : [ { "x" : 538, "y" : 289 } ] } ] } ], "compartments" : [ { "id" : 38848, "reactomeId" : 5460, "displayName" : "mitochondrial matrix", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 361, "y" : 334 }, "minX" : 59, "maxX" : 664, "minY" : 77, "maxY" : 592, "prop" : { "x" : 59, "y" : 77, "width" : 605, "height" : 515 }, "textPosition" : { "x" : 507, "y" : 143 }, "insets" : { "x" : 69, "y" : 87, "width" : 585, "height" : 495 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 38820, 38818, 38822, 38819, 38821, 38823, 38824, 38826, 38827, 38828, 38829, 38830, 38831, 38832, 38834, 38825, 38833 ] }, { "id" : 38847, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 663, "y" : 323 }, "minX" : 0, "maxX" : 1326, "minY" : 0, "maxY" : 646, "prop" : { "x" : 0, "y" : 0, "width" : 1326, "height" : 646 }, "textPosition" : { "x" : 614, "y" : 596 }, "insets" : { "x" : 10, "y" : 10, "width" : 1306, "height" : 626 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 38837, 38838, 38840, 38841, 38836, 38835, 38842, 38843, 38844, 38846, 38845, 38848, 38839 ] } ], "notes" : [ ], "links" : [ ], "shadows" : [ { "id" : 38849, "reactomeId" : 10993627, "displayName" : "Synthesis of Ketone Bodies", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 697, "y" : 250 }, "minX" : 114, "maxX" : 1280, "minY" : 99, "maxY" : 402, "prop" : { "x" : 642, "y" : 99, "width" : 638, "height" : 303 }, "points" : [ { "x" : 114, "y" : 99 }, { "x" : 1280, "y" : 99 }, { "x" : 1280, "y" : 402 }, { "x" : 114, "y" : 402 } ], "colour" : "#4684ee" }, { "id" : 38850, "reactomeId" : 10993641, "displayName" : "Utilization of Ketone Bodies", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 378, "y" : 250 }, "minX" : 114, "maxX" : 642, "minY" : 99, "maxY" : 402, "prop" : { "x" : 114, "y" : 99, "width" : 528, "height" : 303 }, "points" : [ { "x" : 114, "y" : 99 }, { "x" : 642, "y" : 99 }, { "x" : 642, "y" : 402 }, { "x" : 114, "y" : 402 } ], "colour" : "#dc3912" } ], "minX" : 0, "maxX" : 1326, "minY" : 0, "maxY" : 646, "disease" : false }