{ "dbId" : 10993493, "stableId" : "R-CEL-5628897", "displayName" : "TP53 Regulates Metabolic Genes", "nodes" : [ { "id" : 21889, "reactomeId" : 10994581, "displayName" : "Energy dependent regulation of mTOR by LKB1-AMPK", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 430, "y" : 1415 }, "minX" : 345, "maxX" : 515, "minY" : 1385, "maxY" : 1446, "prop" : { "x" : 345, "y" : 1385, "width" : 170, "height" : 61 }, "textPosition" : { "x" : 351, "y" : 1387 }, "connectors" : [ ] }, { "id" : 21891, "reactomeId" : 10927435, "displayName" : "p-T,p-S-AKT", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 114, "y" : 1308 }, "minX" : 70, "maxX" : 158, "minY" : 1297, "maxY" : 1319, "prop" : { "x" : 70, "y" : 1297, "width" : 88, "height" : 22 }, "textPosition" : { "x" : 75, "y" : 1297 }, "connectors" : [ ] }, { "id" : 21833, "reactomeId" : 29512, "displayName" : "Fru(6)P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1362, "y" : 592 }, "minX" : 1329, "maxX" : 1397, "minY" : 574, "maxY" : 609, "prop" : { "x" : 1329, "y" : 575, "width" : 67, "height" : 34 }, "textPosition" : { "x" : 1335, "y" : 581 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1391, "y" : 580 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1391, "y" : 580 } } }, "connectors" : [ { "edgeId" : 21832, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21834, "reactomeId" : 30537, "displayName" : "G6P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1362, "y" : 766 }, "minX" : 1340, "maxX" : 1385, "minY" : 751, "maxY" : 832, "prop" : { "x" : 1340, "y" : 752, "width" : 44, "height" : 29 }, "textPosition" : { "x" : 1345, "y" : 756 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1379, "y" : 757 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1379, "y" : 757 } } }, "connectors" : [ { "edgeId" : 21832, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21836, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1362, "y" : 784 }, "to" : { "x" : 1364, "y" : 832 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21835, "reactomeId" : 10915594, "displayName" : "GPI dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1237, "y" : 688 }, "minX" : 1196, "maxX" : 1352, "minY" : 666, "maxY" : 704, "prop" : { "x" : 1196, "y" : 672, "width" : 82, "height" : 32 }, "textPosition" : { "x" : 1203, "y" : 683 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1278, "y" : 672 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1278, "y" : 672 } } }, "connectors" : [ { "edgeId" : 21832, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1281, "y" : 688 }, "to" : { "x" : 1344, "y" : 688 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1348, "y" : 688 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1348, "y" : 688 } } } ] }, { "id" : 21901, "reactomeId" : 10921219, "displayName" : "RRM2B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 944, "y" : 1011 }, "minX" : 919, "maxX" : 975, "minY" : 994, "maxY" : 1022, "prop" : { "x" : 919, "y" : 1000, "width" : 50, "height" : 22 }, "textPosition" : { "x" : 919, "y" : 1000 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 969, "y" : 1000 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 969, "y" : 1000 } } }, "connectors" : [ ] }, { "id" : 21837, "reactomeId" : 29366, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1204, "y" : 785 }, "minX" : 1115, "maxX" : 1364, "minY" : 769, "maxY" : 1015, "prop" : { "x" : 1173, "y" : 770, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 1178, "y" : 774 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1231, "y" : 775 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1231, "y" : 775 } } }, "connectors" : [ { "edgeId" : 21842, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1198, "y" : 803 }, "to" : { "x" : 1115, "y" : 1015 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1199, "y" : 811 }, "b" : { "x" : 1198, "y" : 803 }, "c" : { "x" : 1192, "y" : 808 }, "type" : "ARROW", "centre" : { "x" : 1192, "y" : 808 } } }, { "edgeId" : 21836, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1239, "y" : 794 }, "to" : { "x" : 1364, "y" : 832 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21838, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1245, "y" : 918 }, "minX" : 1171, "maxX" : 1362, "minY" : 901, "maxY" : 1016, "prop" : { "x" : 1224, "y" : 902, "width" : 42, "height" : 33 }, "textPosition" : { "x" : 1231, "y" : 908 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1261, "y" : 907 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1261, "y" : 907 } } }, "connectors" : [ { "edgeId" : 21842, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1232, "y" : 938 }, "to" : { "x" : 1171, "y" : 1016 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21836, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1269, "y" : 916 }, "to" : { "x" : 1362, "y" : 907 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1276, "y" : 911 }, "b" : { "x" : 1269, "y" : 916 }, "c" : { "x" : 1276, "y" : 919 }, "type" : "ARROW", "centre" : { "x" : 1276, "y" : 919 } } } ], "trivial" : true }, { "id" : 21902, "reactomeId" : 10993567, "displayName" : "Metabolism of nucleotides", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 944, "y" : 1085 }, "minX" : 879, "maxX" : 1009, "minY" : 1059, "maxY" : 1111, "prop" : { "x" : 879, "y" : 1059, "width" : 130, "height" : 52 }, "textPosition" : { "x" : 890, "y" : 1063 }, "connectors" : [ ] }, { "id" : 21903, "reactomeId" : 10915824, "displayName" : "GLS2 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 300, "y" : 337 }, "minX" : 261, "maxX" : 346, "minY" : 320, "maxY" : 348, "prop" : { "x" : 261, "y" : 326, "width" : 79, "height" : 22 }, "textPosition" : { "x" : 261, "y" : 327 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 340, "y" : 326 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 340, "y" : 326 } } }, "connectors" : [ ] }, { "id" : 21839, "reactomeId" : 29364, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1254, "y" : 990 }, "minX" : 1171, "maxX" : 1362, "minY" : 907, "maxY" : 1016, "prop" : { "x" : 1223, "y" : 975, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 1229, "y" : 979 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1281, "y" : 980 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1281, "y" : 980 } } }, "connectors" : [ { "edgeId" : 21842, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1220, "y" : 999 }, "to" : { "x" : 1171, "y" : 1016 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21836, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1273, "y" : 972 }, "to" : { "x" : 1362, "y" : 907 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1276, "y" : 965 }, "b" : { "x" : 1273, "y" : 972 }, "c" : { "x" : 1281, "y" : 971 }, "type" : "ARROW", "centre" : { "x" : 1281, "y" : 971 } } } ] }, { "id" : 21840, "reactomeId" : 31467, "displayName" : "D-Glucono-1,5-lactone 6-phosphate", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1501, "y" : 980 }, "minX" : 1362, "maxX" : 1573, "minY" : 907, "maxY" : 1012, "prop" : { "x" : 1431, "y" : 949, "width" : 141, "height" : 63 }, "textPosition" : { "x" : 1432, "y" : 963 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1567, "y" : 954 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1567, "y" : 954 } } }, "connectors" : [ { "edgeId" : 21836, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1441, "y" : 946 }, "to" : { "x" : 1362, "y" : 907 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1433, "y" : 947 }, "b" : { "x" : 1441, "y" : 946 }, "c" : { "x" : 1437, "y" : 939 }, "type" : "ARROW", "centre" : { "x" : 1437, "y" : 939 } } } ] }, { "id" : 21904, "reactomeId" : 10993503, "displayName" : "Metabolism of amino acids and derivatives", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 311, "y" : 112 }, "minX" : 230, "maxX" : 393, "minY" : 78, "maxY" : 147, "prop" : { "x" : 230, "y" : 78, "width" : 163, "height" : 69 }, "textPosition" : { "x" : 237, "y" : 91 }, "connectors" : [ ] }, { "id" : 21841, "reactomeId" : 10915466, "displayName" : "G6PD dimer and tetramer", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1270, "y" : 865 }, "minX" : 1214, "maxX" : 1356, "minY" : 848, "maxY" : 883, "prop" : { "x" : 1214, "y" : 848, "width" : 113, "height" : 35 }, "textPosition" : { "x" : 1214, "y" : 848 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 21836, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1333, "y" : 863 }, "to" : { "x" : 1348, "y" : 863 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1352, "y" : 863 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1352, "y" : 863 } } } ] }, { "id" : 21906, "reactomeId" : 10993929, "displayName" : "PIP3 activates AKT signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 68, "y" : 1125 }, "minX" : 0, "maxX" : 137, "minY" : 1095, "maxY" : 1155, "prop" : { "x" : 0, "y" : 1095, "width" : 137, "height" : 60 }, "textPosition" : { "x" : 1, "y" : 1103 }, "connectors" : [ ] }, { "id" : 21843, "reactomeId" : 111745, "displayName" : "GSSG", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1255, "y" : 1045 }, "minX" : 1171, "maxX" : 1283, "minY" : 1016, "maxY" : 1204, "prop" : { "x" : 1229, "y" : 1030, "width" : 53, "height" : 30 }, "textPosition" : { "x" : 1234, "y" : 1034 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1277, "y" : 1035 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1277, "y" : 1035 } } }, "connectors" : [ { "edgeId" : 21842, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1226, "y" : 1035 }, "to" : { "x" : 1171, "y" : 1016 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21846, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1254, "y" : 1063 }, "to" : { "x" : 1251, "y" : 1204 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1258, "y" : 1070 }, "b" : { "x" : 1254, "y" : 1063 }, "c" : { "x" : 1250, "y" : 1070 }, "type" : "ARROW", "centre" : { "x" : 1250, "y" : 1070 } } } ] }, { "id" : 21908, "reactomeId" : 10927844, "displayName" : "daf-18", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 90, "y" : 1019 }, "minX" : 70, "maxX" : 116, "minY" : 1002, "maxY" : 1030, "prop" : { "x" : 70, "y" : 1008, "width" : 40, "height" : 22 }, "textPosition" : { "x" : 74, "y" : 1002 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 110, "y" : 1008 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 110, "y" : 1008 } } }, "connectors" : [ ] }, { "id" : 21844, "reactomeId" : 29450, "displayName" : "GSH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1039, "y" : 1020 }, "minX" : 1017, "maxX" : 1115, "minY" : 1004, "maxY" : 1204, "prop" : { "x" : 1017, "y" : 1005, "width" : 45, "height" : 31 }, "textPosition" : { "x" : 1022, "y" : 1010 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1057, "y" : 1010 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1057, "y" : 1010 } } }, "connectors" : [ { "edgeId" : 21842, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1065, "y" : 1018 }, "to" : { "x" : 1115, "y" : 1015 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1084, "y" : 1010 }, "b" : { "x" : 1096, "y" : 1022 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1090, "y" : 1016 } } }, "endShape" : { "a" : { "x" : 1072, "y" : 1014 }, "b" : { "x" : 1065, "y" : 1018 }, "c" : { "x" : 1072, "y" : 1022 }, "type" : "ARROW", "centre" : { "x" : 1072, "y" : 1022 } } }, { "edgeId" : 21846, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1038, "y" : 1039 }, "to" : { "x" : 1034, "y" : 1204 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1030, "y" : 1115 }, "b" : { "x" : 1042, "y" : 1127 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1036, "y" : 1121 } } } } ] }, { "id" : 21845, "reactomeId" : 10916753, "displayName" : "GSR-2:FAD dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1140, "y" : 1091 }, "minX" : 1083, "maxX" : 1203, "minY" : 1024, "maxY" : 1103, "prop" : { "x" : 1083, "y" : 1080, "width" : 114, "height" : 23 }, "textPosition" : { "x" : 1084, "y" : 1082 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1197, "y" : 1080 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1197, "y" : 1080 } } }, "connectors" : [ { "edgeId" : 21842, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1140, "y" : 1077 }, "to" : { "x" : 1140, "y" : 1032 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1140, "y" : 1028 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1140, "y" : 1028 } } } ] }, { "id" : 21847, "reactomeId" : 29408, "displayName" : "H2O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1009, "y" : 1347 }, "minX" : 905, "maxX" : 1037, "minY" : 1204, "maxY" : 1362, "prop" : { "x" : 982, "y" : 1332, "width" : 54, "height" : 30 }, "textPosition" : { "x" : 988, "y" : 1336 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1031, "y" : 1337 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1031, "y" : 1337 } } }, "connectors" : [ { "edgeId" : 21860, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1004, "y" : 1329 }, "to" : { "x" : 968, "y" : 1204 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 980, "y" : 1260 }, "b" : { "x" : 992, "y" : 1272 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 986, "y" : 1266 } } } }, { "edgeId" : 21846, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1011, "y" : 1329 }, "to" : { "x" : 1034, "y" : 1204 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21850, "type" : "INPUT", "segments" : [ { "from" : { "x" : 979, "y" : 1339 }, "to" : { "x" : 905, "y" : 1320 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21848, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1335, "y" : 1203 }, "minX" : 1251, "maxX" : 1359, "minY" : 1185, "maxY" : 1221, "prop" : { "x" : 1313, "y" : 1186, "width" : 45, "height" : 35 }, "textPosition" : { "x" : 1318, "y" : 1193 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1353, "y" : 1191 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1353, "y" : 1191 } } }, "connectors" : [ { "edgeId" : 21846, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1310, "y" : 1203 }, "to" : { "x" : 1251, "y" : 1204 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1274, "y" : 1197 }, "b" : { "x" : 1286, "y" : 1209 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1280, "y" : 1203 } } }, "endShape" : { "a" : { "x" : 1303, "y" : 1207 }, "b" : { "x" : 1310, "y" : 1203 }, "c" : { "x" : 1303, "y" : 1199 }, "type" : "ARROW", "centre" : { "x" : 1303, "y" : 1199 } } } ] }, { "id" : 21849, "reactomeId" : 10956349, "displayName" : "GPX2 tetramer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1149, "y" : 1152 }, "minX" : 1097, "maxX" : 1208, "minY" : 1135, "maxY" : 1196, "prop" : { "x" : 1097, "y" : 1141, "width" : 105, "height" : 22 }, "textPosition" : { "x" : 1100, "y" : 1142 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1202, "y" : 1141 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1202, "y" : 1141 } } }, "connectors" : [ { "edgeId" : 21846, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1149, "y" : 1166 }, "to" : { "x" : 1150, "y" : 1188 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1150, "y" : 1192 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1150, "y" : 1192 } } } ] }, { "id" : 21851, "reactomeId" : 10917989, "displayName" : "trx-1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 917, "y" : 1351 }, "minX" : 899, "maxX" : 942, "minY" : 1320, "maxY" : 1457, "prop" : { "x" : 899, "y" : 1340, "width" : 37, "height" : 22 }, "textPosition" : { "x" : 899, "y" : 1340 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 936, "y" : 1340 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 936, "y" : 1340 } } }, "connectors" : [ { "edgeId" : 21850, "type" : "INPUT", "segments" : [ { "from" : { "x" : 912, "y" : 1337 }, "to" : { "x" : 905, "y" : 1320 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21855, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 916, "y" : 1365 }, "to" : { "x" : 914, "y" : 1457 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 920, "y" : 1372 }, "b" : { "x" : 916, "y" : 1365 }, "c" : { "x" : 912, "y" : 1372 }, "type" : "ARROW", "centre" : { "x" : 912, "y" : 1372 } } } ] }, { "id" : 21852, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 806, "y" : 1372 }, "minX" : 781, "maxX" : 844, "minY" : 1318, "maxY" : 1385, "prop" : { "x" : 781, "y" : 1360, "width" : 50, "height" : 25 }, "textPosition" : { "x" : 789, "y" : 1362 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 826, "y" : 1365 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 826, "y" : 1365 } } }, "connectors" : [ { "edgeId" : 21850, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 814, "y" : 1357 }, "to" : { "x" : 844, "y" : 1318 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 823, "y" : 1331 }, "b" : { "x" : 835, "y" : 1343 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 829, "y" : 1337 } } }, "endShape" : { "a" : { "x" : 815, "y" : 1349 }, "b" : { "x" : 814, "y" : 1357 }, "c" : { "x" : 821, "y" : 1354 }, "type" : "ARROW", "centre" : { "x" : 821, "y" : 1354 } } } ], "trivial" : true }, { "id" : 21853, "reactomeId" : 10917987, "displayName" : "trx-1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 726, "y" : 1343 }, "minX" : 684, "maxX" : 844, "minY" : 1318, "maxY" : 1456, "prop" : { "x" : 684, "y" : 1328, "width" : 84, "height" : 30 }, "textPosition" : { "x" : 708, "y" : 1332 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 768, "y" : 1328 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 768, "y" : 1328 } } }, "connectors" : [ { "edgeId" : 21850, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 771, "y" : 1334 }, "to" : { "x" : 844, "y" : 1318 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 777, "y" : 1329 }, "b" : { "x" : 771, "y" : 1334 }, "c" : { "x" : 779, "y" : 1336 }, "type" : "ARROW", "centre" : { "x" : 779, "y" : 1336 } } }, { "edgeId" : 21855, "type" : "INPUT", "segments" : [ { "from" : { "x" : 729, "y" : 1361 }, "to" : { "x" : 754, "y" : 1456 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21854, "reactomeId" : 10960955, "displayName" : "PRDX1,2,5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 865, "y" : 1261 }, "minX" : 824, "maxX" : 907, "minY" : 1250, "maxY" : 1310, "prop" : { "x" : 824, "y" : 1250, "width" : 83, "height" : 22 }, "textPosition" : { "x" : 829, "y" : 1250 }, "connectors" : [ { "edgeId" : 21850, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 865, "y" : 1278 }, "to" : { "x" : 865, "y" : 1302 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 865, "y" : 1306 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 865, "y" : 1306 } } } ] }, { "id" : 21856, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 700, "y" : 1486 }, "minX" : 679, "maxX" : 754, "minY" : 1456, "maxY" : 1503, "prop" : { "x" : 679, "y" : 1470, "width" : 42, "height" : 33 }, "textPosition" : { "x" : 686, "y" : 1476 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 716, "y" : 1475 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 716, "y" : 1475 } } }, "connectors" : [ { "edgeId" : 21855, "type" : "INPUT", "segments" : [ { "from" : { "x" : 724, "y" : 1474 }, "to" : { "x" : 754, "y" : 1456 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 21857, "reactomeId" : 29364, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 694, "y" : 1425 }, "minX" : 663, "maxX" : 754, "minY" : 1409, "maxY" : 1456, "prop" : { "x" : 663, "y" : 1410, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 669, "y" : 1414 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 721, "y" : 1415 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 721, "y" : 1415 } } }, "connectors" : [ { "edgeId" : 21855, "type" : "INPUT", "segments" : [ { "from" : { "x" : 723, "y" : 1443 }, "to" : { "x" : 754, "y" : 1456 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21858, "reactomeId" : 29366, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 976, "y" : 1474 }, "minX" : 914, "maxX" : 1009, "minY" : 1457, "maxY" : 1489, "prop" : { "x" : 945, "y" : 1459, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 950, "y" : 1463 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1003, "y" : 1464 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1003, "y" : 1464 } } }, "connectors" : [ { "edgeId" : 21855, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 942, "y" : 1465 }, "to" : { "x" : 914, "y" : 1457 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 934, "y" : 1467 }, "b" : { "x" : 942, "y" : 1465 }, "c" : { "x" : 936, "y" : 1459 }, "type" : "ARROW", "centre" : { "x" : 936, "y" : 1459 } } } ] }, { "id" : 21859, "reactomeId" : 10917996, "displayName" : "TNXRD1:FAD dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 854, "y" : 1503 }, "minX" : 794, "maxX" : 921, "minY" : 1465, "maxY" : 1521, "prop" : { "x" : 794, "y" : 1486, "width" : 121, "height" : 35 }, "textPosition" : { "x" : 810, "y" : 1486 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 915, "y" : 1486 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 915, "y" : 1486 } } }, "connectors" : [ { "edgeId" : 21855, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 854, "y" : 1483 }, "to" : { "x" : 855, "y" : 1473 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 855, "y" : 1469 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 855, "y" : 1469 } } } ] }, { "id" : 21861, "reactomeId" : 10960949, "displayName" : "PRDX1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 864, "y" : 1203 }, "minX" : 821, "maxX" : 968, "minY" : 1160, "maxY" : 1214, "prop" : { "x" : 821, "y" : 1192, "width" : 87, "height" : 22 }, "textPosition" : { "x" : 821, "y" : 1193 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 908, "y" : 1192 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 908, "y" : 1192 } } }, "connectors" : [ { "edgeId" : 21860, "type" : "INPUT", "segments" : [ { "from" : { "x" : 911, "y" : 1203 }, "to" : { "x" : 968, "y" : 1204 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21860, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 864, "y" : 1189 }, "to" : { "x" : 865, "y" : 1168 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 865, "y" : 1164 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 865, "y" : 1164 } } } ] }, { "id" : 21862, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 745, "y" : 1196 }, "minX" : 724, "maxX" : 786, "minY" : 1152, "maxY" : 1211, "prop" : { "x" : 724, "y" : 1181, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 728, "y" : 1185 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 762, "y" : 1186 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 762, "y" : 1186 } } }, "connectors" : [ { "edgeId" : 21860, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 758, "y" : 1178 }, "to" : { "x" : 786, "y" : 1152 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 760, "y" : 1170 }, "b" : { "x" : 758, "y" : 1178 }, "c" : { "x" : 766, "y" : 1176 }, "type" : "ARROW", "centre" : { "x" : 766, "y" : 1176 } } } ], "trivial" : true }, { "id" : 21863, "reactomeId" : 10966928, "displayName" : "HOOS-C52-PRDX1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 735, "y" : 1121 }, "minX" : 673, "maxX" : 803, "minY" : 1073, "maxY" : 1152, "prop" : { "x" : 673, "y" : 1103, "width" : 124, "height" : 36 }, "textPosition" : { "x" : 675, "y" : 1104 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 797, "y" : 1103 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 797, "y" : 1103 } } }, "connectors" : [ { "edgeId" : 21860, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 764, "y" : 1142 }, "to" : { "x" : 786, "y" : 1152 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 772, "y" : 1141 }, "b" : { "x" : 764, "y" : 1142 }, "c" : { "x" : 769, "y" : 1149 }, "type" : "ARROW", "centre" : { "x" : 769, "y" : 1149 } } }, { "edgeId" : 21864, "type" : "INPUT", "segments" : [ { "from" : { "x" : 732, "y" : 1100 }, "to" : { "x" : 728, "y" : 1073 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21865, "reactomeId" : 10966936, "displayName" : "sesn-1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 767, "y" : 994 }, "minX" : 440, "maxX" : 818, "minY" : 978, "maxY" : 1095, "prop" : { "x" : 723, "y" : 984, "width" : 89, "height" : 21 }, "textPosition" : { "x" : 742, "y" : 984 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 812, "y" : 984 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 812, "y" : 984 } } }, "connectors" : [ { "edgeId" : 21864, "type" : "INPUT", "segments" : [ { "from" : { "x" : 761, "y" : 1011 }, "to" : { "x" : 728, "y" : 1073 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21871, "type" : "INPUT", "segments" : [ { "from" : { "x" : 733, "y" : 1011 }, "to" : { "x" : 440, "y" : 1095 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21866, "reactomeId" : 10966942, "displayName" : "SESN1,2,3:HOOS-C52-PRDX1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 593, "y" : 1105 }, "minX" : 547, "maxX" : 646, "minY" : 1073, "maxY" : 1131, "prop" : { "x" : 547, "y" : 1079, "width" : 93, "height" : 52 }, "textPosition" : { "x" : 550, "y" : 1082 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 640, "y" : 1079 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 640, "y" : 1079 } } }, "connectors" : [ { "edgeId" : 21864, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21868, "reactomeId" : 10923327, "displayName" : "Active mTORC1 complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 253, "y" : 1571 }, "minX" : 186, "maxX" : 355, "minY" : 1538, "maxY" : 1589, "prop" : { "x" : 186, "y" : 1553, "width" : 135, "height" : 36 }, "textPosition" : { "x" : 201, "y" : 1554 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 321, "y" : 1553 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 321, "y" : 1553 } } }, "connectors" : [ { "edgeId" : 21867, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21867, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 305, "y" : 1550 }, "to" : { "x" : 350, "y" : 1538 } }, { "from" : { "x" : 350, "y" : 1538 }, "to" : { "x" : 350, "y" : 1552 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 351, "y" : 1556 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 351, "y" : 1556 } } } ] }, { "id" : 21869, "reactomeId" : 10934204, "displayName" : "mTORC1:Ragulator:Rag:GNP:RHEB:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 511, "y" : 1572 }, "minX" : 376, "maxX" : 582, "minY" : 1548, "maxY" : 1590, "prop" : { "x" : 446, "y" : 1554, "width" : 130, "height" : 36 }, "textPosition" : { "x" : 446, "y" : 1555 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 576, "y" : 1554 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 576, "y" : 1554 } } }, "connectors" : [ { "edgeId" : 21867, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 443, "y" : 1570 }, "to" : { "x" : 376, "y" : 1569 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 436, "y" : 1574 }, "b" : { "x" : 443, "y" : 1570 }, "c" : { "x" : 436, "y" : 1566 }, "type" : "ARROW", "centre" : { "x" : 436, "y" : 1566 } } } ] }, { "id" : 21870, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 425, "y" : 1614 }, "minX" : 376, "maxX" : 441, "minY" : 1569, "maxY" : 1627, "prop" : { "x" : 410, "y" : 1602, "width" : 30, "height" : 25 }, "textPosition" : { "x" : 415, "y" : 1604 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 435, "y" : 1607 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 435, "y" : 1607 } } }, "connectors" : [ { "edgeId" : 21867, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 411, "y" : 1599 }, "to" : { "x" : 376, "y" : 1569 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 403, "y" : 1598 }, "b" : { "x" : 411, "y" : 1599 }, "c" : { "x" : 408, "y" : 1591 }, "type" : "ARROW", "centre" : { "x" : 408, "y" : 1591 } } } ] }, { "id" : 21872, "reactomeId" : 10934168, "displayName" : "p-AMPK heterotrimer:AMP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 430, "y" : 1285 }, "minX" : 371, "maxX" : 495, "minY" : 1095, "maxY" : 1304, "prop" : { "x" : 371, "y" : 1266, "width" : 118, "height" : 38 }, "textPosition" : { "x" : 371, "y" : 1269 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 489, "y" : 1266 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 489, "y" : 1266 } } }, "connectors" : [ { "edgeId" : 21871, "type" : "INPUT", "segments" : [ { "from" : { "x" : 431, "y" : 1263 }, "to" : { "x" : 440, "y" : 1095 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21873, "reactomeId" : 10966946, "displayName" : "SESN1,2,3:p-AMPK heterotrimer:AMP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 591, "y" : 1200 }, "minX" : 528, "maxX" : 660, "minY" : 1176, "maxY" : 1219, "prop" : { "x" : 528, "y" : 1182, "width" : 126, "height" : 37 }, "textPosition" : { "x" : 528, "y" : 1184 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 654, "y" : 1182 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 654, "y" : 1182 } } }, "connectors" : [ { "edgeId" : 21871, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21875, "reactomeId" : 113522, "displayName" : "L-Gln", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 371, "y" : 341 }, "minX" : 350, "maxX" : 394, "minY" : 315, "maxY" : 355, "prop" : { "x" : 350, "y" : 328, "width" : 43, "height" : 27 }, "textPosition" : { "x" : 352, "y" : 331 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 388, "y" : 333 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 388, "y" : 333 } } }, "connectors" : [ { "edgeId" : 21874, "type" : "INPUT", "segments" : [ { "from" : { "x" : 380, "y" : 325 }, "to" : { "x" : 389, "y" : 315 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21876, "reactomeId" : 113521, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 425, "y" : 334 }, "minX" : 389, "maxX" : 444, "minY" : 315, "maxY" : 348, "prop" : { "x" : 407, "y" : 320, "width" : 36, "height" : 28 }, "textPosition" : { "x" : 408, "y" : 323 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 438, "y" : 325 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 438, "y" : 325 } } }, "connectors" : [ { "edgeId" : 21874, "type" : "INPUT", "segments" : [ { "from" : { "x" : 404, "y" : 324 }, "to" : { "x" : 389, "y" : 315 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 21877, "reactomeId" : 113552, "displayName" : "L-Glu", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 309, "y" : 232 }, "minX" : 288, "maxX" : 387, "minY" : 218, "maxY" : 264, "prop" : { "x" : 288, "y" : 219, "width" : 42, "height" : 27 }, "textPosition" : { "x" : 290, "y" : 222 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 325, "y" : 224 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 325, "y" : 224 } } }, "connectors" : [ { "edgeId" : 21874, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 333, "y" : 240 }, "to" : { "x" : 387, "y" : 264 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 341, "y" : 239 }, "b" : { "x" : 333, "y" : 240 }, "c" : { "x" : 338, "y" : 246 }, "type" : "ARROW", "centre" : { "x" : 338, "y" : 246 } } } ] }, { "id" : 21878, "reactomeId" : 113561, "displayName" : "NH4+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 400, "y" : 231 }, "minX" : 377, "maxX" : 424, "minY" : 218, "maxY" : 264, "prop" : { "x" : 377, "y" : 219, "width" : 46, "height" : 25 }, "textPosition" : { "x" : 378, "y" : 221 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 418, "y" : 224 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 418, "y" : 224 } } }, "connectors" : [ { "edgeId" : 21874, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 395, "y" : 247 }, "to" : { "x" : 387, "y" : 264 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 396, "y" : 255 }, "b" : { "x" : 395, "y" : 247 }, "c" : { "x" : 388, "y" : 252 }, "type" : "ARROW", "centre" : { "x" : 388, "y" : 252 } } } ] }, { "id" : 21879, "reactomeId" : 10915826, "displayName" : "GLS dimers", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 301, "y" : 295 }, "minX" : 262, "maxX" : 382, "minY" : 284, "maxY" : 306, "prop" : { "x" : 262, "y" : 284, "width" : 78, "height" : 22 }, "textPosition" : { "x" : 262, "y" : 284 }, "connectors" : [ { "edgeId" : 21874, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 346, "y" : 295 }, "to" : { "x" : 374, "y" : 295 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 378, "y" : 295 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 378, "y" : 295 } } } ] }, { "id" : 21885, "reactomeId" : 10993467, "displayName" : "Metabolism of carbohydrates and carbohydrate derivatives", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1499, "y" : 594 }, "minX" : 1436, "maxX" : 1562, "minY" : 565, "maxY" : 624, "prop" : { "x" : 1436, "y" : 565, "width" : 126, "height" : 59 }, "textPosition" : { "x" : 1443, "y" : 552 }, "connectors" : [ ] }, { "id" : 21886, "reactomeId" : 10993561, "displayName" : "Detoxification of Reactive Oxygen Species", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1459, "y" : 1076 }, "minX" : 1371, "maxX" : 1547, "minY" : 1038, "maxY" : 1114, "prop" : { "x" : 1371, "y" : 1038, "width" : 176, "height" : 76 }, "textPosition" : { "x" : 1370, "y" : 1054 }, "connectors" : [ ] } ], "edges" : [ { "id" : 21842, "reactomeId" : 10916756, "displayName" : "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1140, "y" : 1016 }, "minX" : 1115, "maxX" : 1171, "minY" : 1010, "maxY" : 1022, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1171, "y" : 1016 }, "to" : { "x" : 1140, "y" : 1016 } }, { "from" : { "x" : 1140, "y" : 1016 }, "to" : { "x" : 1115, "y" : 1015 } } ], "reactionShape" : { "a" : { "x" : 1134, "y" : 1010 }, "b" : { "x" : 1146, "y" : 1022 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1140, "y" : 1016 } }, "inputs" : [ { "id" : 21843, "points" : [ { "x" : 1226, "y" : 1035 } ] }, { "id" : 21838, "points" : [ { "x" : 1232, "y" : 938 } ] }, { "id" : 21839, "points" : [ { "x" : 1220, "y" : 999 } ] } ], "outputs" : [ { "id" : 21844, "points" : [ { "x" : 1065, "y" : 1018 } ], "stoichiometry" : 2 }, { "id" : 21837, "points" : [ { "x" : 1198, "y" : 803 } ] } ], "catalysts" : [ { "id" : 21845, "points" : [ { "x" : 1140, "y" : 1077 } ] } ] }, { "id" : 21874, "reactomeId" : 10915829, "displayName" : "glutamine + H2O => glutamate + NH4+ (GLS)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 390, "y" : 295 }, "minX" : 384, "maxX" : 396, "minY" : 264, "maxY" : 315, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 389, "y" : 315 }, "to" : { "x" : 390, "y" : 295 } }, { "from" : { "x" : 390, "y" : 295 }, "to" : { "x" : 387, "y" : 264 } } ], "reactionShape" : { "a" : { "x" : 384, "y" : 289 }, "b" : { "x" : 396, "y" : 301 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 390, "y" : 295 } }, "inputs" : [ { "id" : 21875, "points" : [ { "x" : 380, "y" : 325 } ] }, { "id" : 21876, "points" : [ { "x" : 404, "y" : 324 } ] } ], "outputs" : [ { "id" : 21877, "points" : [ { "x" : 333, "y" : 240 } ] }, { "id" : 21878, "points" : [ { "x" : 395, "y" : 247 } ] } ], "catalysts" : [ { "id" : 21879, "points" : [ { "x" : 346, "y" : 295 } ] } ] }, { "id" : 21860, "reactomeId" : 10966931, "displayName" : "PRDX1 overoxidizes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 866, "y" : 1152 }, "minX" : 786, "maxX" : 969, "minY" : 1146, "maxY" : 1204, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 968, "y" : 1204 }, "to" : { "x" : 969, "y" : 1153 } }, { "from" : { "x" : 969, "y" : 1153 }, "to" : { "x" : 866, "y" : 1152 } }, { "from" : { "x" : 866, "y" : 1152 }, "to" : { "x" : 786, "y" : 1152 } } ], "reactionShape" : { "a" : { "x" : 860, "y" : 1146 }, "b" : { "x" : 872, "y" : 1158 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 866, "y" : 1152 } }, "inputs" : [ { "id" : 21861, "points" : [ { "x" : 911, "y" : 1203 } ] }, { "id" : 21847, "points" : [ { "x" : 1004, "y" : 1329 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 21862, "points" : [ { "x" : 758, "y" : 1178 } ] }, { "id" : 21863, "points" : [ { "x" : 764, "y" : 1142 } ] } ], "catalysts" : [ { "id" : 21861, "points" : [ { "x" : 864, "y" : 1189 } ] } ] }, { "id" : 21846, "reactomeId" : 10960932, "displayName" : "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1150, "y" : 1204 }, "minX" : 1034, "maxX" : 1251, "minY" : 1198, "maxY" : 1210, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1034, "y" : 1204 }, "to" : { "x" : 1150, "y" : 1204 } }, { "from" : { "x" : 1150, "y" : 1204 }, "to" : { "x" : 1251, "y" : 1204 } } ], "reactionShape" : { "a" : { "x" : 1144, "y" : 1198 }, "b" : { "x" : 1156, "y" : 1210 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1150, "y" : 1204 } }, "inputs" : [ { "id" : 21847, "points" : [ { "x" : 1011, "y" : 1329 } ] }, { "id" : 21844, "points" : [ { "x" : 1038, "y" : 1039 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 21843, "points" : [ { "x" : 1254, "y" : 1063 } ] }, { "id" : 21848, "points" : [ { "x" : 1310, "y" : 1203 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 21849, "points" : [ { "x" : 1149, "y" : 1166 } ] } ] }, { "id" : 21864, "reactomeId" : 10966944, "displayName" : "SESN1,2,3 bind overoxidized PRDX1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 727, "y" : 1073 }, "minX" : 643, "maxX" : 733, "minY" : 1067, "maxY" : 1093, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 728, "y" : 1073 }, "to" : { "x" : 727, "y" : 1073 } }, { "from" : { "x" : 727, "y" : 1073 }, "to" : { "x" : 643, "y" : 1093 } } ], "endShape" : { "a" : { "x" : 649, "y" : 1088 }, "b" : { "x" : 643, "y" : 1093 }, "c" : { "x" : 651, "y" : 1095 }, "type" : "ARROW", "centre" : { "x" : 651, "y" : 1095 } }, "reactionShape" : { "c" : { "x" : 727, "y" : 1073 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 727, "y" : 1073 } }, "inputs" : [ { "id" : 21863, "points" : [ { "x" : 732, "y" : 1100 } ] }, { "id" : 21865, "points" : [ { "x" : 761, "y" : 1011 } ] } ], "outputs" : [ { "id" : 21866 } ] }, { "id" : 21832, "reactomeId" : 10915599, "displayName" : "GPI dimer isomerizes Fru(6)P to G6P", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1360, "y" : 688 }, "minX" : 1354, "maxX" : 1366, "minY" : 612, "maxY" : 749, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1361, "y" : 612 }, "to" : { "x" : 1360, "y" : 688 } }, { "from" : { "x" : 1360, "y" : 688 }, "to" : { "x" : 1361, "y" : 749 } } ], "endShape" : { "a" : { "x" : 1357, "y" : 742 }, "b" : { "x" : 1361, "y" : 749 }, "c" : { "x" : 1365, "y" : 742 }, "type" : "ARROW", "centre" : { "x" : 1365, "y" : 742 } }, "reactionShape" : { "a" : { "x" : 1354, "y" : 682 }, "b" : { "x" : 1366, "y" : 694 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1360, "y" : 688 } }, "inputs" : [ { "id" : 21833 } ], "outputs" : [ { "id" : 21834 } ], "catalysts" : [ { "id" : 21835, "points" : [ { "x" : 1281, "y" : 688 } ] } ] }, { "id" : 21850, "reactomeId" : 10960958, "displayName" : "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 865, "y" : 1318 }, "minX" : 844, "maxX" : 905, "minY" : 1312, "maxY" : 1324, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 905, "y" : 1320 }, "to" : { "x" : 865, "y" : 1318 } }, { "from" : { "x" : 865, "y" : 1318 }, "to" : { "x" : 844, "y" : 1318 } } ], "reactionShape" : { "a" : { "x" : 859, "y" : 1312 }, "b" : { "x" : 871, "y" : 1324 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 865, "y" : 1318 } }, "inputs" : [ { "id" : 21851, "points" : [ { "x" : 912, "y" : 1337 } ] }, { "id" : 21847, "points" : [ { "x" : 979, "y" : 1339 } ] } ], "outputs" : [ { "id" : 21852, "points" : [ { "x" : 814, "y" : 1357 } ], "stoichiometry" : 2 }, { "id" : 21853, "points" : [ { "x" : 771, "y" : 1334 } ] } ], "catalysts" : [ { "id" : 21854, "points" : [ { "x" : 865, "y" : 1278 } ] } ] }, { "id" : 21867, "reactomeId" : 10934207, "displayName" : "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 351, "y" : 1568 }, "minX" : 324, "maxX" : 376, "minY" : 1562, "maxY" : 1574, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 324, "y" : 1568 }, "to" : { "x" : 351, "y" : 1568 } }, { "from" : { "x" : 351, "y" : 1568 }, "to" : { "x" : 376, "y" : 1569 } } ], "reactionShape" : { "a" : { "x" : 345, "y" : 1562 }, "b" : { "x" : 357, "y" : 1574 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 351, "y" : 1568 } }, "inputs" : [ { "id" : 21868 } ], "outputs" : [ { "id" : 21869, "points" : [ { "x" : 443, "y" : 1570 } ] }, { "id" : 21870, "points" : [ { "x" : 411, "y" : 1599 } ] } ], "catalysts" : [ { "id" : 21868, "points" : [ { "x" : 305, "y" : 1550 }, { "x" : 350, "y" : 1538 } ] } ] }, { "id" : 21836, "reactomeId" : 10915469, "displayName" : "G6PD multimers dehydrogenate G6P", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1364, "y" : 863 }, "minX" : 1358, "maxX" : 1370, "minY" : 832, "maxY" : 907, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1364, "y" : 832 }, "to" : { "x" : 1364, "y" : 863 } }, { "from" : { "x" : 1364, "y" : 863 }, "to" : { "x" : 1362, "y" : 907 } } ], "reactionShape" : { "a" : { "x" : 1358, "y" : 857 }, "b" : { "x" : 1370, "y" : 869 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1364, "y" : 863 } }, "inputs" : [ { "id" : 21834, "points" : [ { "x" : 1362, "y" : 784 } ] }, { "id" : 21837, "points" : [ { "x" : 1239, "y" : 794 } ] } ], "outputs" : [ { "id" : 21838, "points" : [ { "x" : 1269, "y" : 916 } ] }, { "id" : 21839, "points" : [ { "x" : 1273, "y" : 972 } ] }, { "id" : 21840, "points" : [ { "x" : 1441, "y" : 946 } ] } ], "catalysts" : [ { "id" : 21841, "points" : [ { "x" : 1333, "y" : 863 } ] } ] }, { "id" : 21871, "reactomeId" : 10966948, "displayName" : "SESN1,2,3 bind AMPK", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 502, "y" : 1137 }, "minX" : 434, "maxX" : 564, "minY" : 1089, "maxY" : 1179, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 440, "y" : 1095 }, "to" : { "x" : 502, "y" : 1137 } }, { "from" : { "x" : 502, "y" : 1137 }, "to" : { "x" : 564, "y" : 1179 } } ], "endShape" : { "a" : { "x" : 556, "y" : 1178 }, "b" : { "x" : 564, "y" : 1179 }, "c" : { "x" : 561, "y" : 1172 }, "type" : "ARROW", "centre" : { "x" : 561, "y" : 1172 } }, "reactionShape" : { "c" : { "x" : 502, "y" : 1137 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 502, "y" : 1137 } }, "inputs" : [ { "id" : 21872, "points" : [ { "x" : 431, "y" : 1263 } ] }, { "id" : 21865, "points" : [ { "x" : 733, "y" : 1011 } ] } ], "outputs" : [ { "id" : 21873 } ] }, { "id" : 21855, "reactomeId" : 10917999, "displayName" : "Regeneration of active (reduced) Thioredoxin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 856, "y" : 1457 }, "minX" : 754, "maxX" : 914, "minY" : 1451, "maxY" : 1463, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 754, "y" : 1456 }, "to" : { "x" : 856, "y" : 1457 } }, { "from" : { "x" : 856, "y" : 1457 }, "to" : { "x" : 914, "y" : 1457 } } ], "reactionShape" : { "a" : { "x" : 850, "y" : 1451 }, "b" : { "x" : 862, "y" : 1463 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 856, "y" : 1457 } }, "inputs" : [ { "id" : 21856, "points" : [ { "x" : 724, "y" : 1474 } ] }, { "id" : 21857, "points" : [ { "x" : 723, "y" : 1443 } ] }, { "id" : 21853, "points" : [ { "x" : 729, "y" : 1361 } ] } ], "outputs" : [ { "id" : 21851, "points" : [ { "x" : 916, "y" : 1365 } ] }, { "id" : 21858, "points" : [ { "x" : 942, "y" : 1465 } ] } ], "catalysts" : [ { "id" : 21859, "points" : [ { "x" : 854, "y" : 1483 } ] } ] } ], "compartments" : [ { "id" : 21907, "reactomeId" : 161320, "displayName" : "lysosomal lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 384, "y" : 1537 }, "minX" : 231, "maxX" : 537, "minY" : 1489, "maxY" : 1586, "prop" : { "x" : 231, "y" : 1489, "width" : 306, "height" : 97 }, "textPosition" : { "x" : 263, "y" : 1506 }, "insets" : { "x" : 241, "y" : 1499, "width" : 286, "height" : 77 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 21868, 21869, 21867 ] }, { "id" : 21894, "reactomeId" : 5460, "displayName" : "mitochondrial matrix", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 569, "y" : 285 }, "minX" : 225, "maxX" : 914, "minY" : 193, "maxY" : 377, "prop" : { "x" : 225, "y" : 193, "width" : 689, "height" : 184 }, "textPosition" : { "x" : 443, "y" : 225 }, "insets" : { "x" : 235, "y" : 203, "width" : 669, "height" : 164 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 21903, 21920, 21874, 21879, 21878, 21877, 21875, 21876 ] }, { "id" : 21895, "reactomeId" : 17927, "displayName" : "mitochondrial intermembrane space", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 674, "y" : 255 }, "minX" : 189, "maxX" : 1160, "minY" : 103, "maxY" : 407, "prop" : { "x" : 189, "y" : 103, "width" : 971, "height" : 304 }, "textPosition" : { "x" : 909, "y" : 353 }, "insets" : { "x" : 199, "y" : 113, "width" : 951, "height" : 284 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 21894, 21904, 21921 ] }, { "id" : 21881, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 865, "y" : 833 }, "minX" : 9, "maxX" : 1721, "minY" : 0, "maxY" : 1666, "prop" : { "x" : 9, "y" : 0, "width" : 1712, "height" : 1666 }, "textPosition" : { "x" : 542, "y" : 1599 }, "insets" : { "x" : 19, "y" : 10, "width" : 1692, "height" : 1646 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 21833, 21882, 21885, 21911, 21832, 21834, 21835, 21836, 21840, 21839, 21837, 21841, 21838, 21912, 21886, 21843, 21844, 21845, 21842, 21848, 21849, 21847, 21846, 21913, 21914, 21915, 21865, 21850, 21851, 21852, 21854, 21855, 21859, 21858, 21856, 21857, 21860, 21861, 21916, 21863, 21862, 21864, 21866, 21872, 21889, 21917, 21871, 21873, 21891, 21895, 21906, 21922, 21907, 21870, 21902, 21901, 21908, 21923, 21853 ] }, { "id" : 21882, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 652, "y" : 711 }, "minX" : 187, "maxX" : 1118, "minY" : 452, "maxY" : 970, "prop" : { "x" : 187, "y" : 452, "width" : 931, "height" : 518 }, "textPosition" : { "x" : 619, "y" : 916 }, "insets" : { "x" : 197, "y" : 462, "width" : 911, "height" : 498 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 21918, 21919 ] } ], "notes" : [ ], "links" : [ { "id" : 21920, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 300, "y" : 317 }, "minX" : 294, "maxX" : 306, "minY" : 311, "maxY" : 323, "segments" : [ { "from" : { "x" : 300, "y" : 323 }, "to" : { "x" : 300, "y" : 312 } } ], "reactionShape" : { "a" : { "x" : 294, "y" : 311 }, "b" : { "x" : 306, "y" : 323 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 300, "y" : 317 } }, "inputs" : [ { "id" : 21903 } ], "outputs" : [ { "id" : 21879 } ] }, { "id" : 21921, "renderableClass" : "Interaction", "position" : { "x" : 309, "y" : 183 }, "minX" : 303, "maxX" : 315, "minY" : 150, "maxY" : 216, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 309, "y" : 216 }, "to" : { "x" : 310, "y" : 150 } } ], "endShape" : { "a" : { "x" : 314, "y" : 157 }, "b" : { "x" : 310, "y" : 150 }, "c" : { "x" : 306, "y" : 157 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 306, "y" : 157 } }, "reactionShape" : { "a" : { "x" : 303, "y" : 177 }, "b" : { "x" : 315, "y" : 189 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 309, "y" : 183 } }, "inputs" : [ { "id" : 21877 } ], "outputs" : [ { "id" : 21904 } ] }, { "id" : 21922, "renderableClass" : "Interaction", "position" : { "x" : 93, "y" : 1224 }, "minX" : 75, "maxX" : 111, "minY" : 1158, "maxY" : 1291, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 75, "y" : 1158 }, "to" : { "x" : 111, "y" : 1291 } } ], "endShape" : { "a" : { "x" : 105, "y" : 1285 }, "b" : { "x" : 111, "y" : 1291 }, "c" : { "x" : 113, "y" : 1283 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 113, "y" : 1283 } }, "reactionShape" : { "a" : { "x" : 87, "y" : 1218 }, "b" : { "x" : 99, "y" : 1230 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 93, "y" : 1224 } }, "inputs" : [ { "id" : 21906 } ], "outputs" : [ { "id" : 21891 } ] }, { "id" : 21923, "renderableClass" : "Interaction", "position" : { "x" : 80, "y" : 1062 }, "minX" : 74, "maxX" : 87, "minY" : 1033, "maxY" : 1092, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 87, "y" : 1033 }, "to" : { "x" : 74, "y" : 1092 } } ], "endShape" : { "a" : { "x" : 72, "y" : 1084 }, "b" : { "x" : 74, "y" : 1092 }, "c" : { "x" : 79, "y" : 1086 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 79, "y" : 1086 } }, "reactionShape" : { "a" : { "x" : 74, "y" : 1056 }, "b" : { "x" : 86, "y" : 1068 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 80, "y" : 1062 } }, "inputs" : [ { "id" : 21908 } ], "outputs" : [ { "id" : 21906 } ] }, { "id" : 21911, "renderableClass" : "Interaction", "position" : { "x" : 1416, "y" : 592 }, "minX" : 1399, "maxX" : 1433, "minY" : 586, "maxY" : 598, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1399, "y" : 592 }, "to" : { "x" : 1433, "y" : 592 } } ], "endShape" : { "a" : { "x" : 1426, "y" : 596 }, "b" : { "x" : 1433, "y" : 592 }, "c" : { "x" : 1426, "y" : 588 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1426, "y" : 588 } }, "reactionShape" : { "a" : { "x" : 1410, "y" : 586 }, "b" : { "x" : 1422, "y" : 598 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1416, "y" : 592 } }, "inputs" : [ { "id" : 21833 } ], "outputs" : [ { "id" : 21885 } ] }, { "id" : 21912, "renderableClass" : "Interaction", "position" : { "x" : 1499, "y" : 786 }, "minX" : 1493, "maxX" : 1505, "minY" : 627, "maxY" : 946, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1500, "y" : 946 }, "to" : { "x" : 1499, "y" : 627 } } ], "endShape" : { "a" : { "x" : 1503, "y" : 634 }, "b" : { "x" : 1499, "y" : 627 }, "c" : { "x" : 1495, "y" : 634 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1495, "y" : 634 } }, "reactionShape" : { "a" : { "x" : 1493, "y" : 780 }, "b" : { "x" : 1505, "y" : 792 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1499, "y" : 786 } }, "inputs" : [ { "id" : 21840 } ], "outputs" : [ { "id" : 21885 } ] }, { "id" : 21913, "renderableClass" : "Interaction", "position" : { "x" : 1424, "y" : 688 }, "minX" : 1373, "maxX" : 1475, "minY" : 627, "maxY" : 749, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1475, "y" : 627 }, "to" : { "x" : 1373, "y" : 749 } } ], "endShape" : { "a" : { "x" : 1374, "y" : 741 }, "b" : { "x" : 1373, "y" : 749 }, "c" : { "x" : 1381, "y" : 746 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1381, "y" : 746 } }, "reactionShape" : { "a" : { "x" : 1418, "y" : 682 }, "b" : { "x" : 1430, "y" : 694 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1424, "y" : 688 } }, "inputs" : [ { "id" : 21885 } ], "outputs" : [ { "id" : 21834 } ] }, { "id" : 21914, "renderableClass" : "Interaction", "position" : { "x" : 1326, "y" : 1054 }, "minX" : 1285, "maxX" : 1368, "minY" : 1048, "maxY" : 1061, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1368, "y" : 1061 }, "to" : { "x" : 1285, "y" : 1048 } } ], "endShape" : { "a" : { "x" : 1292, "y" : 1045 }, "b" : { "x" : 1285, "y" : 1048 }, "c" : { "x" : 1291, "y" : 1053 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1291, "y" : 1053 } }, "reactionShape" : { "a" : { "x" : 1320, "y" : 1048 }, "b" : { "x" : 1332, "y" : 1060 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1326, "y" : 1054 } }, "inputs" : [ { "id" : 21886 } ], "outputs" : [ { "id" : 21843 } ] }, { "id" : 21915, "renderableClass" : "Interaction", "position" : { "x" : 1386, "y" : 1150 }, "minX" : 1352, "maxX" : 1421, "minY" : 1117, "maxY" : 1183, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1352, "y" : 1183 }, "to" : { "x" : 1421, "y" : 1117 } } ], "endShape" : { "a" : { "x" : 1419, "y" : 1125 }, "b" : { "x" : 1421, "y" : 1117 }, "c" : { "x" : 1413, "y" : 1119 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1413, "y" : 1119 } }, "reactionShape" : { "a" : { "x" : 1380, "y" : 1144 }, "b" : { "x" : 1392, "y" : 1156 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1386, "y" : 1150 } }, "inputs" : [ { "id" : 21848 } ], "outputs" : [ { "id" : 21886 } ] }, { "id" : 21916, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 864, "y" : 1230 }, "minX" : 858, "maxX" : 870, "minY" : 1217, "maxY" : 1244, "segments" : [ { "from" : { "x" : 864, "y" : 1217 }, "to" : { "x" : 864, "y" : 1244 } } ], "reactionShape" : { "a" : { "x" : 858, "y" : 1224 }, "b" : { "x" : 870, "y" : 1236 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 864, "y" : 1230 } }, "inputs" : [ { "id" : 21861 } ], "outputs" : [ { "id" : 21854 } ] }, { "id" : 21917, "renderableClass" : "Interaction", "position" : { "x" : 430, "y" : 1344 }, "minX" : 424, "maxX" : 436, "minY" : 1307, "maxY" : 1382, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 430, "y" : 1382 }, "to" : { "x" : 430, "y" : 1307 } } ], "endShape" : { "a" : { "x" : 434, "y" : 1314 }, "b" : { "x" : 430, "y" : 1307 }, "c" : { "x" : 426, "y" : 1314 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 426, "y" : 1314 } }, "reactionShape" : { "a" : { "x" : 424, "y" : 1338 }, "b" : { "x" : 436, "y" : 1350 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 430, "y" : 1344 } }, "inputs" : [ { "id" : 21889 } ], "outputs" : [ { "id" : 21872 } ] }, { "id" : 21919, "renderableClass" : "Interaction", "position" : { "x" : 944, "y" : 1040 }, "minX" : 938, "maxX" : 950, "minY" : 1025, "maxY" : 1056, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 944, "y" : 1025 }, "to" : { "x" : 944, "y" : 1056 } } ], "endShape" : { "a" : { "x" : 940, "y" : 1049 }, "b" : { "x" : 944, "y" : 1056 }, "c" : { "x" : 948, "y" : 1049 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 948, "y" : 1049 } }, "reactionShape" : { "a" : { "x" : 938, "y" : 1034 }, "b" : { "x" : 950, "y" : 1046 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 944, "y" : 1040 } }, "inputs" : [ { "id" : 21901 } ], "outputs" : [ { "id" : 21902 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 1721, "minY" : 0, "maxY" : 1666, "disease" : false }