{
  "dbId" : 10913440,
  "stId" : "R-DME-9909649",
  "speciesName" : "Drosophila melanogaster",
  "nodes" : [ {
    "dbId" : 10908966,
    "stId" : "R-DME-9909596",
    "displayName" : "MLL1,MLL3_complex:CD274 gene H3K4me3 chromatin [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 113488 ],
    "parents" : [ ],
    "children" : [ 10908960, 10908964 ]
  }, {
    "dbId" : 10908964,
    "stId" : "R-DME-9971740",
    "displayName" : "CD274 gene H3K4me3 chromatin [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "parents" : [ 10908966 ],
    "children" : [ 10908956, 10897654 ]
  }, {
    "dbId" : 10908962,
    "stId" : "R-DME-9909595",
    "displayName" : "CD274 gene chromatin:MLL1,MLL3 complex [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 113484 ],
    "parents" : [ ],
    "children" : [ 10908958, 10908960 ]
  }, {
    "dbId" : 10908960,
    "stId" : "R-DME-9909647",
    "displayName" : "MLL1,MLL3 complex [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 56210,
    "diagramIds" : [ 113483 ],
    "parents" : [ 10908966, 10908962 ],
    "children" : [ 10897618, 10897604 ]
  }, {
    "dbId" : 10845923,
    "stId" : "R-DME-212278",
    "displayName" : "escl [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q9VKD5",
    "standardIdentifier" : "uniprot:Q9VKD5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "escl" ],
    "parents" : [ 10845940 ],
    "children" : [ ]
  }, {
    "dbId" : 10845933,
    "stId" : "R-DME-212217",
    "displayName" : "Su(z)12 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q9NJG9",
    "standardIdentifier" : "uniprot:Q9NJG9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Su(z)12" ],
    "parents" : [ 10845940 ],
    "children" : [ ]
  }, {
    "dbId" : 10908975,
    "stId" : "R-DME-9680425",
    "displayName" : "fs(1)h [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "diagramIds" : [ 113480 ],
    "identifier" : "P13709",
    "standardIdentifier" : "uniprot:P13709",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "fs(1)h" ],
    "parents" : [ 10908977 ],
    "children" : [ ]
  }, {
    "dbId" : 10897647,
    "stId" : "R-DME-1214216-3",
    "displayName" : "Homologues of Me3K5-H3F3A [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 56210,
    "parents" : [ 10897652 ],
    "children" : [ 10897642, 10897645 ]
  }, {
    "dbId" : 10897645,
    "stId" : "R-DME-1214216-2",
    "displayName" : "His3.3B [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "C0HL67",
    "standardIdentifier" : "uniprot:C0HL67",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "His3.3B" ],
    "parents" : [ 10897647 ],
    "children" : [ ]
  }, {
    "dbId" : 10897642,
    "stId" : "R-DME-1214216",
    "displayName" : "His3.3A [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "C0HL66",
    "standardIdentifier" : "uniprot:C0HL66",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "His3.3A" ],
    "parents" : [ 10897647 ],
    "children" : [ ]
  }, {
    "dbId" : 10845928,
    "stId" : "R-DME-212298",
    "displayName" : "E(z) [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P42124",
    "standardIdentifier" : "uniprot:P42124",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "E(z)" ],
    "parents" : [ 10845940 ],
    "children" : [ ]
  }, {
    "dbId" : 10908971,
    "stId" : "R-DME-9909625",
    "displayName" : "PRC2(EZH2) Core:Nucleosome:CD274 gene promoter [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 113490 ],
    "parents" : [ ],
    "children" : [ 10908956, 10845916, 10845940 ]
  }, {
    "dbId" : 10897654,
    "stId" : "R-DME-1214169",
    "displayName" : "Nucleosome with H3K4me3 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "parents" : [ 10908964 ],
    "children" : [ 10833997, 10833981, 10897652, 10833988 ]
  }, {
    "dbId" : 10845940,
    "stId" : "R-DME-212285",
    "displayName" : "PRC2 (EZH2) Core [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 113491 ],
    "parents" : [ 10908971 ],
    "children" : [ 10845928, 10845933, 10845938, 10845923 ]
  }, {
    "dbId" : 10897652,
    "stId" : "R-DME-1214232",
    "displayName" : "Histone H3 (H3K4me3) [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 56210,
    "parents" : [ 10897654 ],
    "children" : [ 10897647, 10897650 ]
  }, {
    "dbId" : 10897650,
    "stId" : "R-DME-1214223",
    "displayName" : "His3:CG33845 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P02299",
    "standardIdentifier" : "uniprot:P02299",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "His3:CG33845" ],
    "parents" : [ 10897652 ],
    "children" : [ ]
  }, {
    "dbId" : 10873458,
    "stId" : "R-DME-1629838",
    "displayName" : "wds [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q9V3J8",
    "standardIdentifier" : "uniprot:Q9V3J8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "wds" ],
    "parents" : [ 10873744 ],
    "children" : [ ]
  }, {
    "dbId" : 10908977,
    "stId" : "R-DME-9909636",
    "displayName" : "BRD4:CD274 gene chromatin [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 113481 ],
    "parents" : [ ],
    "children" : [ 10908975, 10908958 ]
  }, {
    "dbId" : 10845938,
    "stId" : "R-DME-212223",
    "displayName" : "Caf1-55 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q24572",
    "standardIdentifier" : "uniprot:Q24572",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Caf1-55" ],
    "parents" : [ 10845940 ],
    "children" : [ ]
  }, {
    "dbId" : 10897598,
    "stId" : "R-DME-9818591",
    "displayName" : "KMT2A(1-2718) [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P20659",
    "standardIdentifier" : "uniprot:P20659",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10897602 ],
    "children" : [ ]
  }, {
    "dbId" : 10833981,
    "stId" : "R-DME-181902",
    "displayName" : "His4:CG33889 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P84040",
    "standardIdentifier" : "uniprot:P84040",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "His4:CG33889" ],
    "parents" : [ 10897654, 10845916 ],
    "children" : [ ]
  }, {
    "dbId" : 77087,
    "stId" : "R-ALL-77087",
    "displayName" : "AdoMet [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 113486 ],
    "identifier" : "59789",
    "standardIdentifier" : "chebi:59789",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10833988,
    "stId" : "R-DME-181899",
    "displayName" : "Histone H2A [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 56210,
    "parents" : [ 10897654, 10845916 ],
    "children" : [ 10833986 ]
  }, {
    "dbId" : 10897604,
    "stId" : "R-DME-9675218",
    "displayName" : "MLL1 complex [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "parents" : [ 10908960 ],
    "children" : [ 10873744, 10897602 ]
  }, {
    "dbId" : 10873735,
    "stId" : "R-DME-1629834",
    "displayName" : "ASH2L [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q94545",
    "standardIdentifier" : "uniprot:Q94545",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10873744 ],
    "children" : [ ]
  }, {
    "dbId" : 10897602,
    "stId" : "R-DME-9818587",
    "displayName" : "KMT2A dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "parents" : [ 10897604 ],
    "children" : [ 10897598, 10897600 ]
  }, {
    "dbId" : 10897600,
    "stId" : "R-DME-9818593",
    "displayName" : "KMT2A(2719-3969) [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P20659",
    "standardIdentifier" : "uniprot:P20659",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10897602 ],
    "children" : [ ]
  }, {
    "dbId" : 10833986,
    "stId" : "R-DME-8862427",
    "displayName" : "His2Av [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P08985",
    "standardIdentifier" : "uniprot:P08985",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "His2Av" ],
    "parents" : [ 10833988 ],
    "children" : [ ]
  }, {
    "dbId" : 10897614,
    "stId" : "R-DME-1183224-2",
    "displayName" : "Lpt [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q9W1H0",
    "standardIdentifier" : "uniprot:Q9W1H0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Lpt" ],
    "parents" : [ 10897616 ],
    "children" : [ ]
  }, {
    "dbId" : 10833997,
    "stId" : "R-DME-181911",
    "displayName" : "Histone H2B [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 56210,
    "parents" : [ 10897654, 10845916 ],
    "children" : [ 10833993 ]
  }, {
    "dbId" : 10873742,
    "stId" : "R-DME-1629836",
    "displayName" : "Rbbp5 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q9VPH8",
    "standardIdentifier" : "uniprot:Q9VPH8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Rbbp5" ],
    "parents" : [ 10873744 ],
    "children" : [ ]
  }, {
    "dbId" : 10873737,
    "stId" : "R-DME-5669104",
    "displayName" : "Ghost homologue of DPY30 [nucleoplasm]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 56210,
    "parents" : [ 10873744 ],
    "children" : [ ]
  }, {
    "dbId" : 10833993,
    "stId" : "R-DME-181898",
    "displayName" : "His2B [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P02283",
    "standardIdentifier" : "uniprot:P02283",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "His2B" ],
    "parents" : [ 10833997 ],
    "children" : [ ]
  }, {
    "dbId" : 10897609,
    "stId" : "R-DME-1183224",
    "displayName" : "trr [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q8IRW8",
    "standardIdentifier" : "uniprot:Q8IRW8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "trr" ],
    "parents" : [ 10897616 ],
    "children" : [ ]
  }, {
    "dbId" : 10845908,
    "stId" : "R-DME-212295",
    "displayName" : "His3.3A [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "C0HL66",
    "standardIdentifier" : "uniprot:C0HL66",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "His3.3A" ],
    "parents" : [ 10845912 ],
    "children" : [ ]
  }, {
    "dbId" : 10845910,
    "stId" : "R-DME-212295-2",
    "displayName" : "His3.3B [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "C0HL67",
    "standardIdentifier" : "uniprot:C0HL67",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "His3.3B" ],
    "parents" : [ 10845912 ],
    "children" : [ ]
  }, {
    "dbId" : 10897618,
    "stId" : "R-DME-9676265",
    "displayName" : "MLL3 complex [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "parents" : [ 10908960 ],
    "children" : [ 10897616, 10873744 ]
  }, {
    "dbId" : 10873744,
    "stId" : "R-DME-9675213",
    "displayName" : "WRAD complex [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "parents" : [ 10897604, 10897618 ],
    "children" : [ 10873737, 10873742, 10873458, 10873735 ]
  }, {
    "dbId" : 10897616,
    "stId" : "R-DME-1183224-3",
    "displayName" : "Homologues of KMT2C [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 56210,
    "parents" : [ 10897618 ],
    "children" : [ 10897609, 10897614 ]
  }, {
    "dbId" : 10845906,
    "stId" : "R-DME-212281",
    "displayName" : "His3:CG33845 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P02299",
    "standardIdentifier" : "uniprot:P02299",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "His3:CG33845" ],
    "parents" : [ 10845914 ],
    "children" : [ ]
  }, {
    "dbId" : 10908958,
    "stId" : "R-DME-9909633",
    "displayName" : "CD274 gene chromatin [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 113479 ],
    "parents" : [ 10908977, 10908962 ],
    "children" : [ 10908956, 10845916 ]
  }, {
    "dbId" : 10845916,
    "stId" : "R-DME-427402",
    "displayName" : "Nucleosome [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "parents" : [ 10908971, 10908958 ],
    "children" : [ 10845914, 10833997, 10833981, 10833988 ]
  }, {
    "dbId" : 10908956,
    "stId" : "R-DME-9701419",
    "displayName" : "Ghost homologue of CD274 gene [nucleoplasm]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 56210,
    "parents" : [ 10908971, 10908964, 10908958 ],
    "children" : [ ]
  }, {
    "dbId" : 10845912,
    "stId" : "R-DME-212295-3",
    "displayName" : "Homologues of H3F3A [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 56210,
    "parents" : [ 10845914 ],
    "children" : [ 10845910, 10845908 ]
  }, {
    "dbId" : 10845914,
    "stId" : "R-DME-212293",
    "displayName" : "Histone H3 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 56210,
    "parents" : [ 10845916 ],
    "children" : [ 10845912, 10845906 ]
  }, {
    "dbId" : 77502,
    "stId" : "R-ALL-77502",
    "displayName" : "AdoHcy [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 113487 ],
    "identifier" : "57856",
    "standardIdentifier" : "chebi:57856",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10908981,
    "stId" : "R-DME-9909646",
    "displayName" : "MLL1,MLL3 complex binding to CD274 gene chromatin",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10908969 ],
    "inputs" : [ 10908958, 10908960 ],
    "outputs" : [ 10908962 ],
    "efs" : [ ],
    "diagramIds" : [ 113482 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10908979,
    "stId" : "R-DME-9909635",
    "displayName" : "BRD4 binding to CD274 gene chromatin",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10908975, 10908958 ],
    "outputs" : [ 10908977 ],
    "efs" : [ ],
    "diagramIds" : [ 113478 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10908973,
    "stId" : "R-DME-9909631",
    "displayName" : "Trimethylation of CD274 gene promoter by EZH2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 77087, 10908971 ],
    "outputs" : [ 77502, 10908971 ],
    "catalysts" : [ 10845940 ],
    "efs" : [ ],
    "diagramIds" : [ 113489 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10908969,
    "stId" : "R-DME-9909628",
    "displayName" : "Trimethylation of CD274 gene chromatin by MLL1/3 complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10908981 ],
    "inputs" : [ 77087, 10908962 ],
    "outputs" : [ 77502, 10908966 ],
    "catalysts" : [ 10908962 ],
    "efs" : [ ],
    "diagramIds" : [ 113485 ],
    "entityFunctionalStatus" : [ ]
  } ]
}