{ "dbId" : 10913412, "stableId" : "R-DME-9818564", "displayName" : "Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "nodes" : [ { "id" : 42112, "reactomeId" : 10907883, "displayName" : "PPARG ligands:PPARG:RXRA ligands:RXRA:adipogenesis genes:Nucleosomes", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3543, "y" : 1065 }, "minX" : 3247, "maxX" : 3891, "minY" : 1033, "maxY" : 1098, "prop" : { "x" : 3418, "y" : 1033, "width" : 251, "height" : 65 }, "textPosition" : { "x" : 3428, "y" : 1041 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 42114, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3675, "y" : 1069 }, "to" : { "x" : 3891, "y" : 1077 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 42111, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3412, "y" : 1061 }, "to" : { "x" : 3247, "y" : 1056 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3405, "y" : 1065 }, "b" : { "x" : 3412, "y" : 1061 }, "c" : { "x" : 3405, "y" : 1057 }, "type" : "ARROW", "centre" : { "x" : 3405, "y" : 1057 } } } ] }, { "id" : 42113, "reactomeId" : 10907715, "displayName" : "NCoR/SMRT complex", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3293, "y" : 1164 }, "minX" : 3247, "maxX" : 3336, "minY" : 1056, "maxY" : 1183, "prop" : { "x" : 3251, "y" : 1146, "width" : 85, "height" : 37 }, "textPosition" : { "x" : 3252, "y" : 1147 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 42111, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3285, "y" : 1140 }, "to" : { "x" : 3247, "y" : 1056 } } ], "stoichiometry" : { "value" : 26, "shape" : { "a" : { "x" : 3260, "y" : 1092 }, "b" : { "x" : 3272, "y" : 1104 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3266, "y" : 1098 } } }, "endShape" : { "a" : { "x" : 3279, "y" : 1135 }, "b" : { "x" : 3285, "y" : 1140 }, "c" : { "x" : 3286, "y" : 1132 }, "type" : "ARROW", "centre" : { "x" : 3286, "y" : 1132 } } } ] }, { "id" : 42115, "reactomeId" : 10850144, "displayName" : "nej", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3834, "y" : 1197 }, "minX" : 3805, "maxX" : 3891, "minY" : 1077, "maxY" : 1214, "prop" : { "x" : 3805, "y" : 1181, "width" : 58, "height" : 33 }, "textPosition" : { "x" : 3820, "y" : 1187 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3863, "y" : 1181 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3863, "y" : 1181 } } }, "connectors" : [ { "edgeId" : 42114, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3841, "y" : 1175 }, "to" : { "x" : 3891, "y" : 1077 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 42116, "reactomeId" : 10907980, "displayName" : "TRAP coactivator complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3707, "y" : 1141 }, "minX" : 3650, "maxX" : 3891, "minY" : 1077, "maxY" : 1159, "prop" : { "x" : 3650, "y" : 1123, "width" : 115, "height" : 36 }, "textPosition" : { "x" : 3649, "y" : 1124 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3765, "y" : 1123 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3765, "y" : 1123 } } }, "connectors" : [ { "edgeId" : 42114, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3758, "y" : 1120 }, "to" : { "x" : 3891, "y" : 1077 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 42117, "reactomeId" : 10907982, "displayName" : "(NCOA1, NCOA2, NCOA3)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 3872, "y" : 1252 }, "minX" : 3815, "maxX" : 3929, "minY" : 1077, "maxY" : 1271, "prop" : { "x" : 3815, "y" : 1234, "width" : 114, "height" : 37 }, "textPosition" : { "x" : 3815, "y" : 1235 }, "connectors" : [ { "edgeId" : 42114, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3874, "y" : 1228 }, "to" : { "x" : 3891, "y" : 1077 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 42118, "reactomeId" : 10898050, "displayName" : "srl", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3720, "y" : 1214 }, "minX" : 3679, "maxX" : 3891, "minY" : 1077, "maxY" : 1233, "prop" : { "x" : 3679, "y" : 1195, "width" : 82, "height" : 38 }, "textPosition" : { "x" : 3708, "y" : 1203 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3761, "y" : 1195 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3761, "y" : 1195 } } }, "connectors" : [ { "edgeId" : 42114, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3743, "y" : 1189 }, "to" : { "x" : 3891, "y" : 1077 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 42119, "reactomeId" : 10908036, "displayName" : "Activated PPARG:RXRA:adipogenesis genes:Nucleosomes", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 4185, "y" : 1054 }, "minX" : 4036, "maxX" : 4334, "minY" : 1018, "maxY" : 1091, "prop" : { "x" : 4036, "y" : 1018, "width" : 298, "height" : 73 }, "textPosition" : { "x" : 4044, "y" : 1037 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 42114, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 42120, "reactomeId" : 10908038, "displayName" : "jub", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 4038, "y" : 1144 }, "minX" : 3945, "maxX" : 4083, "minY" : 1069, "maxY" : 1156, "prop" : { "x" : 4000, "y" : 1133, "width" : 77, "height" : 23 }, "textPosition" : { "x" : 4025, "y" : 1134 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4077, "y" : 1133 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4077, "y" : 1133 } } }, "connectors" : [ { "edgeId" : 42114, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 4023, "y" : 1130 }, "to" : { "x" : 3945, "y" : 1069 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3953, "y" : 1070 }, "b" : { "x" : 3945, "y" : 1069 }, "c" : { "x" : 3948, "y" : 1076 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3948, "y" : 1076 } } } ] }, { "id" : 42122, "reactomeId" : 10907304, "displayName" : "phospho-p-Y226,Y393-ABL1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 405, "y" : 978 }, "minX" : 339, "maxX" : 622, "minY" : 909, "maxY" : 996, "prop" : { "x" : 339, "y" : 966, "width" : 132, "height" : 24 }, "textPosition" : { "x" : 348, "y" : 961 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 471, "y" : 966 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 471, "y" : 966 } } }, "connectors" : [ { "edgeId" : 42121, "type" : "INPUT", "segments" : [ { "from" : { "x" : 399, "y" : 963 }, "to" : { "x" : 374, "y" : 909 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 42125, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 474, "y" : 983 }, "to" : { "x" : 622, "y" : 996 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 481, "y" : 980 }, "b" : { "x" : 474, "y" : 983 }, "c" : { "x" : 481, "y" : 988 }, "type" : "ARROW", "centre" : { "x" : 481, "y" : 988 } } } ] }, { "id" : 42123, "reactomeId" : 10848301, "displayName" : "Eip75B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 275, "y" : 914 }, "minX" : 247, "maxX" : 374, "minY" : 897, "maxY" : 925, "prop" : { "x" : 247, "y" : 903, "width" : 56, "height" : 22 }, "textPosition" : { "x" : 249, "y" : 903 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 303, "y" : 903 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 303, "y" : 903 } } }, "connectors" : [ { "edgeId" : 42121, "type" : "INPUT", "segments" : [ { "from" : { "x" : 306, "y" : 912 }, "to" : { "x" : 374, "y" : 909 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 42124, "reactomeId" : 10907306, "displayName" : "p-Y226,Y393-ABL1:PPARG2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 583, "y" : 890 }, "minX" : 523, "maxX" : 649, "minY" : 866, "maxY" : 961, "prop" : { "x" : 523, "y" : 872, "width" : 120, "height" : 37 }, "textPosition" : { "x" : 537, "y" : 874 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 643, "y" : 872 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 643, "y" : 872 } } }, "connectors" : [ { "edgeId" : 42121, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 42125, "type" : "INPUT", "segments" : [ { "from" : { "x" : 598, "y" : 912 }, "to" : { "x" : 613, "y" : 927 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 42125, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 579, "y" : 912 }, "to" : { "x" : 569, "y" : 955 } }, { "from" : { "x" : 569, "y" : 955 }, "to" : { "x" : 617, "y" : 957 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 621, "y" : 957 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 621, "y" : 957 } } } ] }, { "id" : 42126, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 730, "y" : 892 }, "minX" : 613, "maxX" : 752, "minY" : 878, "maxY" : 927, "prop" : { "x" : 710, "y" : 879, "width" : 41, "height" : 27 }, "textPosition" : { "x" : 715, "y" : 882 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 746, "y" : 884 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 746, "y" : 884 } } }, "connectors" : [ { "edgeId" : 42125, "type" : "INPUT", "segments" : [ { "from" : { "x" : 707, "y" : 898 }, "to" : { "x" : 613, "y" : 927 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 654, "y" : 906 }, "b" : { "x" : 666, "y" : 918 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 660, "y" : 912 } } } } ] }, { "id" : 42127, "reactomeId" : 10907310, "displayName" : "phospho-Eip75B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 771, "y" : 938 }, "minX" : 622, "maxX" : 850, "minY" : 921, "maxY" : 996, "prop" : { "x" : 699, "y" : 927, "width" : 145, "height" : 22 }, "textPosition" : { "x" : 716, "y" : 927 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 844, "y" : 927 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 844, "y" : 927 } } }, "connectors" : [ { "edgeId" : 42125, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 742, "y" : 952 }, "to" : { "x" : 622, "y" : 996 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 737, "y" : 958 }, "b" : { "x" : 742, "y" : 952 }, "c" : { "x" : 734, "y" : 951 }, "type" : "ARROW", "centre" : { "x" : 734, "y" : 951 } } } ] }, { "id" : 42128, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 719, "y" : 1015 }, "minX" : 622, "maxX" : 738, "minY" : 996, "maxY" : 1030, "prop" : { "x" : 701, "y" : 1000, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 702, "y" : 1004 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 732, "y" : 1005 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 732, "y" : 1005 } } }, "connectors" : [ { "edgeId" : 42125, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 698, "y" : 1011 }, "to" : { "x" : 622, "y" : 996 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 654, "y" : 997 }, "b" : { "x" : 666, "y" : 1009 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 660, "y" : 1003 } } }, "endShape" : { "a" : { "x" : 690, "y" : 1014 }, "b" : { "x" : 698, "y" : 1011 }, "c" : { "x" : 692, "y" : 1006 }, "type" : "ARROW", "centre" : { "x" : 692, "y" : 1006 } } } ] }, { "id" : 42101, "reactomeId" : 10907695, "displayName" : "PPARG:RXRA:Adipogenesis genes:Nucleosomes", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1489, "y" : 1061 }, "minX" : 1417, "maxX" : 1626, "minY" : 1027, "maxY" : 1096, "prop" : { "x" : 1417, "y" : 1027, "width" : 145, "height" : 69 }, "textPosition" : { "x" : 1420, "y" : 1037 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 42100, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1568, "y" : 1057 }, "to" : { "x" : 1626, "y" : 1055 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 42102, "reactomeId" : 10907715, "displayName" : "NCoR/SMRT complex", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1580, "y" : 976 }, "minX" : 1538, "maxX" : 1626, "minY" : 958, "maxY" : 1055, "prop" : { "x" : 1538, "y" : 958, "width" : 85, "height" : 37 }, "textPosition" : { "x" : 1539, "y" : 959 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 42100, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1590, "y" : 1001 }, "to" : { "x" : 1626, "y" : 1055 } } ], "stoichiometry" : { "value" : 26, "shape" : { "a" : { "x" : 1602, "y" : 1022 }, "b" : { "x" : 1614, "y" : 1034 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1608, "y" : 1028 } } } } ] }, { "id" : 42103, "reactomeId" : 10907769, "displayName" : "PPARG:RXRA:NCoR/SMRT:adipogenesis genes:Nucleosomes (repressive chromatin state)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1872, "y" : 1087 }, "minX" : 1777, "maxX" : 1967, "minY" : 1061, "maxY" : 1113, "prop" : { "x" : 1777, "y" : 1061, "width" : 190, "height" : 52 }, "textPosition" : { "x" : 1787, "y" : 1056 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 42100, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 42104, "reactomeId" : 10851378, "displayName" : "SIRT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1710, "y" : 1228 }, "minX" : 1683, "maxX" : 1737, "minY" : 1063, "maxY" : 1240, "prop" : { "x" : 1689, "y" : 1217, "width" : 42, "height" : 23 }, "textPosition" : { "x" : 1689, "y" : 1218 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1731, "y" : 1217 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1731, "y" : 1217 } } }, "connectors" : [ { "edgeId" : 42100, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1708, "y" : 1214 }, "to" : { "x" : 1686, "y" : 1063 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1691, "y" : 1069 }, "b" : { "x" : 1686, "y" : 1063 }, "c" : { "x" : 1683, "y" : 1070 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1683, "y" : 1070 } } } ] }, { "id" : 42105, "reactomeId" : 10907771, "displayName" : "CDK5", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1776, "y" : 1219 }, "minX" : 1689, "maxX" : 3960, "minY" : 1062, "maxY" : 1299, "prop" : { "x" : 1753, "y" : 1208, "width" : 47, "height" : 23 }, "textPosition" : { "x" : 1756, "y" : 1209 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1800, "y" : 1208 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1800, "y" : 1208 } } }, "connectors" : [ { "edgeId" : 42114, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1783, "y" : 1234 }, "to" : { "x" : 1813, "y" : 1279 } }, { "from" : { "x" : 1813, "y" : 1279 }, "to" : { "x" : 3960, "y" : 1299 } }, { "from" : { "x" : 3960, "y" : 1299 }, "to" : { "x" : 3939, "y" : 1072 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3935, "y" : 1072 }, "b" : { "x" : 3943, "y" : 1072 }, "c" : { "x" : 3939, "y" : 1072 }, "type" : "STOP", "centre" : { "x" : 3939, "y" : 1072 } } }, { "edgeId" : 42100, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1769, "y" : 1205 }, "to" : { "x" : 1689, "y" : 1062 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1696, "y" : 1066 }, "b" : { "x" : 1689, "y" : 1062 }, "c" : { "x" : 1689, "y" : 1070 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1689, "y" : 1070 } } } ] }, { "id" : 42106, "reactomeId" : 10830210, "displayName" : "Homologues of RB1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1655, "y" : 1227 }, "minX" : 1640, "maxX" : 1686, "minY" : 1063, "maxY" : 1239, "prop" : { "x" : 1640, "y" : 1216, "width" : 31, "height" : 23 }, "textPosition" : { "x" : 1638, "y" : 1175 }, "connectors" : [ { "edgeId" : 42100, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1656, "y" : 1213 }, "to" : { "x" : 1683, "y" : 1063 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1686, "y" : 1071 }, "b" : { "x" : 1683, "y" : 1063 }, "c" : { "x" : 1678, "y" : 1069 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1678, "y" : 1069 } } } ] }, { "id" : 42108, "reactomeId" : 10907939, "displayName" : "PPARG ligands:PPARG:RXRA:Corepressors:adipogenesis genes:Nucleosomes", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2363, "y" : 1072 }, "minX" : 2258, "maxX" : 2580, "minY" : 1045, "maxY" : 1100, "prop" : { "x" : 2258, "y" : 1045, "width" : 210, "height" : 55 }, "textPosition" : { "x" : 2271, "y" : 1048 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 42107, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2474, "y" : 1071 }, "to" : { "x" : 2580, "y" : 1071 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 42109, "reactomeId" : 9844664, "displayName" : "RXRA natural ligands", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2556, "y" : 972 }, "minX" : 2489, "maxX" : 2624, "minY" : 961, "maxY" : 1071, "prop" : { "x" : 2489, "y" : 961, "width" : 135, "height" : 23 }, "textPosition" : { "x" : 2510, "y" : 955 }, "connectors" : [ { "edgeId" : 42107, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2558, "y" : 990 }, "to" : { "x" : 2580, "y" : 1071 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 42110, "reactomeId" : 10907829, "displayName" : "PPARG ligands:PPARG:RXRA ligands:RXRA:Corepressors:adipogenesis genes:Nucleosomes", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2992, "y" : 1066 }, "minX" : 2874, "maxX" : 3111, "minY" : 1021, "maxY" : 1112, "prop" : { "x" : 2874, "y" : 1021, "width" : 237, "height" : 91 }, "textPosition" : { "x" : 2877, "y" : 1042 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 42107, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 42111, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 42114, "reactomeId" : 10908040, "displayName" : "Coactivators are recruited to liganded PPARG:RXRA heterodimer", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3938, "y" : 1063 }, "minX" : 3891, "maxX" : 4030, "minY" : 1057, "maxY" : 1077, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3891, "y" : 1077 }, "to" : { "x" : 3938, "y" : 1063 } }, { "from" : { "x" : 3938, "y" : 1063 }, "to" : { "x" : 4030, "y" : 1059 } } ], "endShape" : { "a" : { "x" : 4023, "y" : 1063 }, "b" : { "x" : 4030, "y" : 1059 }, "c" : { "x" : 4023, "y" : 1055 }, "type" : "ARROW", "centre" : { "x" : 4023, "y" : 1055 } }, "reactionShape" : { "a" : { "x" : 3932, "y" : 1057 }, "b" : { "x" : 3944, "y" : 1069 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3938, "y" : 1063 } }, "inputs" : [ { "id" : 42115, "points" : [ { "x" : 3841, "y" : 1175 } ] }, { "id" : 42116, "points" : [ { "x" : 3758, "y" : 1120 } ] }, { "id" : 42117, "points" : [ { "x" : 3874, "y" : 1228 } ] }, { "id" : 42112, "points" : [ { "x" : 3675, "y" : 1069 } ] }, { "id" : 42118, "points" : [ { "x" : 3743, "y" : 1189 } ] } ], "outputs" : [ { "id" : 42119 } ], "inhibitors" : [ { "id" : 42105, "points" : [ { "x" : 1783, "y" : 1234 }, { "x" : 1813, "y" : 1279 }, { "x" : 3960, "y" : 1299 } ] } ], "activators" : [ { "id" : 42120, "points" : [ { "x" : 4023, "y" : 1130 } ] } ] }, { "id" : 42100, "reactomeId" : 10907773, "displayName" : "Unliganded PPARG:RXRA heterodimer recruits corepressors to target gene loci", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1685, "y" : 1054 }, "minX" : 1626, "maxX" : 1771, "minY" : 1048, "maxY" : 1070, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1626, "y" : 1055 }, "to" : { "x" : 1685, "y" : 1054 } }, { "from" : { "x" : 1685, "y" : 1054 }, "to" : { "x" : 1771, "y" : 1070 } } ], "endShape" : { "a" : { "x" : 1763, "y" : 1073 }, "b" : { "x" : 1771, "y" : 1070 }, "c" : { "x" : 1765, "y" : 1065 }, "type" : "ARROW", "centre" : { "x" : 1765, "y" : 1065 } }, "reactionShape" : { "a" : { "x" : 1679, "y" : 1048 }, "b" : { "x" : 1691, "y" : 1060 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1685, "y" : 1054 } }, "inputs" : [ { "id" : 42101, "points" : [ { "x" : 1568, "y" : 1057 } ] }, { "id" : 42102, "points" : [ { "x" : 1590, "y" : 1001 } ], "stoichiometry" : 26 } ], "outputs" : [ { "id" : 42103 } ], "activators" : [ { "id" : 42104, "points" : [ { "x" : 1708, "y" : 1214 } ] }, { "id" : 42105, "points" : [ { "x" : 1769, "y" : 1205 } ] }, { "id" : 42106, "points" : [ { "x" : 1656, "y" : 1213 } ] } ] }, { "id" : 42121, "reactomeId" : 10907315, "displayName" : "ABL1 binds PPARG2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 420, "y" : 896 }, "minX" : 374, "maxX" : 520, "minY" : 890, "maxY" : 909, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 374, "y" : 909 }, "to" : { "x" : 420, "y" : 896 } }, { "from" : { "x" : 420, "y" : 896 }, "to" : { "x" : 520, "y" : 892 } } ], "endShape" : { "a" : { "x" : 513, "y" : 896 }, "b" : { "x" : 520, "y" : 892 }, "c" : { "x" : 513, "y" : 888 }, "type" : "ARROW", "centre" : { "x" : 513, "y" : 888 } }, "reactionShape" : { "c" : { "x" : 420, "y" : 896 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 420, "y" : 896 } }, "inputs" : [ { "id" : 42122, "points" : [ { "x" : 399, "y" : 963 } ] }, { "id" : 42123, "points" : [ { "x" : 306, "y" : 912 } ] } ], "outputs" : [ { "id" : 42124 } ] }, { "id" : 42107, "reactomeId" : 10907941, "displayName" : "RXRA binds ligands", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2687, "y" : 1071 }, "minX" : 2580, "maxX" : 2868, "minY" : 1065, "maxY" : 1077, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2580, "y" : 1071 }, "to" : { "x" : 2687, "y" : 1071 } }, { "from" : { "x" : 2687, "y" : 1071 }, "to" : { "x" : 2868, "y" : 1067 } } ], "endShape" : { "a" : { "x" : 2861, "y" : 1071 }, "b" : { "x" : 2868, "y" : 1067 }, "c" : { "x" : 2861, "y" : 1063 }, "type" : "ARROW", "centre" : { "x" : 2861, "y" : 1063 } }, "reactionShape" : { "a" : { "x" : 2681, "y" : 1065 }, "b" : { "x" : 2693, "y" : 1077 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2687, "y" : 1071 } }, "inputs" : [ { "id" : 42108, "points" : [ { "x" : 2474, "y" : 1071 } ] }, { "id" : 42109, "points" : [ { "x" : 2558, "y" : 990 } ] } ], "outputs" : [ { "id" : 42110 } ] }, { "id" : 42125, "reactomeId" : 10907313, "displayName" : "ABL1 phosphorylates PPARG2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 633, "y" : 958 }, "minX" : 613, "maxX" : 639, "minY" : 927, "maxY" : 996, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 613, "y" : 927 }, "to" : { "x" : 633, "y" : 958 } }, { "from" : { "x" : 633, "y" : 958 }, "to" : { "x" : 622, "y" : 996 } } ], "reactionShape" : { "a" : { "x" : 627, "y" : 952 }, "b" : { "x" : 639, "y" : 964 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 633, "y" : 958 } }, "inputs" : [ { "id" : 42126, "points" : [ { "x" : 707, "y" : 898 } ], "stoichiometry" : 2 }, { "id" : 42124, "points" : [ { "x" : 598, "y" : 912 } ] } ], "outputs" : [ { "id" : 42122, "points" : [ { "x" : 474, "y" : 983 } ] }, { "id" : 42127, "points" : [ { "x" : 742, "y" : 952 } ] }, { "id" : 42128, "points" : [ { "x" : 698, "y" : 1011 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 42124, "points" : [ { "x" : 579, "y" : 912 }, { "x" : 569, "y" : 955 } ] } ] }, { "id" : 42111, "reactomeId" : 10907885, "displayName" : "Corepressors are released from liganded PPARG:RXRA heterodimer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3205, "y" : 1054 }, "minX" : 3117, "maxX" : 3247, "minY" : 1048, "maxY" : 1060, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3117, "y" : 1059 }, "to" : { "x" : 3205, "y" : 1054 } }, { "from" : { "x" : 3205, "y" : 1054 }, "to" : { "x" : 3247, "y" : 1056 } } ], "reactionShape" : { "a" : { "x" : 3199, "y" : 1048 }, "b" : { "x" : 3211, "y" : 1060 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3205, "y" : 1054 } }, "inputs" : [ { "id" : 42110 } ], "outputs" : [ { "id" : 42112, "points" : [ { "x" : 3412, "y" : 1061 } ] }, { "id" : 42113, "points" : [ { "x" : 3285, "y" : 1140 } ], "stoichiometry" : 26 } ] } ], "compartments" : [ { "id" : 42145, "reactomeId" : 12045, "displayName" : "endoplasmic reticulum membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 3609, "y" : 174 }, "minX" : 3274, "maxX" : 3944, "minY" : 132, "maxY" : 217, "prop" : { "x" : 3274, "y" : 132, "width" : 670, "height" : 85 }, "textPosition" : { "x" : 3344, "y" : 136 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 42163, "reactomeId" : 5460, "displayName" : "mitochondrial matrix", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 6164, "y" : 651 }, "minX" : 6082, "maxX" : 6247, "minY" : 544, "maxY" : 758, "prop" : { "x" : 6082, "y" : 544, "width" : 165, "height" : 214 }, "textPosition" : { "x" : 6092, "y" : 713 }, "insets" : { "x" : 6092, "y" : 554, "width" : 145, "height" : 194 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 42131, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2940, "y" : 983 }, "minX" : 47, "maxX" : 5833, "minY" : 284, "maxY" : 1682, "prop" : { "x" : 47, "y" : 284, "width" : 5786, "height" : 1398 }, "textPosition" : { "x" : 87, "y" : 1297 }, "insets" : { "x" : 57, "y" : 294, "width" : 5766, "height" : 1378 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 42123, 42180, 42101, 42100, 42103, 42108, 42107, 42109, 42110, 42111, 42112, 42114, 42119, 42181, 42182, 42183, 42184, 42185, 42186, 42187, 42188, 42189, 42102, 42190, 42191, 42192, 42193, 42194, 42195, 42196, 42197, 42198, 42199, 42200, 42201, 42202, 42203, 42121, 42122, 42124, 42125, 42126, 42127, 42204, 42128, 42116, 42118, 42115, 42205, 42206, 42207, 42106, 42105, 42104, 42120, 42117, 42113, 42208 ] }, { "id" : 42132, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 3270, "y" : 977 }, "minX" : 0, "maxX" : 6541, "minY" : 0, "maxY" : 1955, "prop" : { "x" : 0, "y" : 0, "width" : 6541, "height" : 1955 }, "textPosition" : { "x" : 54, "y" : 1739 }, "insets" : { "x" : 10, "y" : 10, "width" : 6521, "height" : 1935 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 42131, 42140, 42145, 42150, 42165 ] }, { "id" : 42165, "reactomeId" : 17947, "displayName" : "peroxisomal membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 6069, "y" : 989 }, "minX" : 5989, "maxX" : 6149, "minY" : 938, "maxY" : 1041, "prop" : { "x" : 5989, "y" : 938, "width" : 160, "height" : 103 }, "textPosition" : { "x" : 5990, "y" : 972 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 42150, "reactomeId" : 17906, "displayName" : "mitochondrial outer membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 6156, "y" : 685 }, "minX" : 6038, "maxX" : 6274, "minY" : 514, "maxY" : 856, "prop" : { "x" : 6038, "y" : 514, "width" : 236, "height" : 342 }, "textPosition" : { "x" : 6045, "y" : 815 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 42163 ] }, { "id" : 42140, "reactomeId" : 13977, "displayName" : "lipid droplet", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 4708, "y" : 148 }, "minX" : 4351, "maxX" : 5066, "minY" : 25, "maxY" : 272, "prop" : { "x" : 4351, "y" : 25, "width" : 715, "height" : 247 }, "textPosition" : { "x" : 4635, "y" : 133 }, "insets" : { "x" : 4361, "y" : 35, "width" : 695, "height" : 227 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } } ], "notes" : [ ], "links" : [ ], "shadows" : [ { "id" : 42166, "reactomeId" : 10913410, "displayName" : "Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2290, "y" : 1071 }, "minX" : 237, "maxX" : 4344, "minY" : 862, "maxY" : 1281, "prop" : { "x" : 237, "y" : 862, "width" : 4107, "height" : 419 }, "points" : [ { "x" : 237, "y" : 862 }, { "x" : 4344, "y" : 862 }, { "x" : 4344, "y" : 1281 }, { "x" : 237, "y" : 1281 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 6541, "minY" : 0, "maxY" : 1955, "disease" : false }