{
  "dbId" : 10913168,
  "stableId" : "R-DME-451927",
  "displayName" : "Interleukin-2 family signaling",
  "nodes" : [ {
    "id" : 3968,
    "reactomeId" : 10904256,
    "displayName" : "JAK3:JAK3 inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 673,
      "y" : 102
    },
    "minX" : 601,
    "maxX" : 752,
    "minY" : 85,
    "maxY" : 113,
    "prop" : {
      "x" : 601,
      "y" : 91,
      "width" : 145,
      "height" : 22
    },
    "textPosition" : {
      "x" : 610,
      "y" : 92
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 746,
          "y" : 91
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 746,
          "y" : 91
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 3965,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3986,
    "reactomeId" : 10912862,
    "displayName" : "RAF/MAP kinase cascade",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 408,
      "y" : 1637
    },
    "minX" : 341,
    "maxX" : 475,
    "minY" : 1607,
    "maxY" : 1668,
    "prop" : {
      "x" : 341,
      "y" : 1607,
      "width" : 134,
      "height" : 61
    },
    "textPosition" : {
      "x" : 349,
      "y" : 1616
    },
    "connectors" : [ ]
  }, {
    "id" : 3991,
    "reactomeId" : 10913172,
    "displayName" : "Interleukin-9 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 528,
      "y" : 770
    },
    "minX" : 473,
    "maxX" : 584,
    "minY" : 743,
    "maxY" : 798,
    "prop" : {
      "x" : 473,
      "y" : 743,
      "width" : 111,
      "height" : 55
    },
    "textPosition" : {
      "x" : 479,
      "y" : 749
    },
    "connectors" : [ ]
  }, {
    "id" : 3992,
    "reactomeId" : 10913166,
    "displayName" : "Interleukin-15 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 671,
      "y" : 772
    },
    "minX" : 608,
    "maxX" : 735,
    "minY" : 742,
    "maxY" : 802,
    "prop" : {
      "x" : 608,
      "y" : 742,
      "width" : 127,
      "height" : 60
    },
    "textPosition" : {
      "x" : 618,
      "y" : 750
    },
    "connectors" : [ ]
  }, {
    "id" : 3966,
    "reactomeId" : 9678772,
    "displayName" : "JAK3 inhibitors",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 688,
      "y" : 182
    },
    "minX" : 625,
    "maxX" : 740,
    "minY" : 138,
    "maxY" : 194,
    "prop" : {
      "x" : 636,
      "y" : 171,
      "width" : 104,
      "height" : 23
    },
    "textPosition" : {
      "x" : 640,
      "y" : 172
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 3965,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 671,
          "y" : 165
        },
        "to" : {
          "x" : 625,
          "y" : 138
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3967,
    "reactomeId" : 10856148,
    "displayName" : "JAK3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 522,
      "y" : 104
    },
    "minX" : 504,
    "maxX" : 625,
    "minY" : 87,
    "maxY" : 138,
    "prop" : {
      "x" : 504,
      "y" : 93,
      "width" : 36,
      "height" : 23
    },
    "textPosition" : {
      "x" : 505,
      "y" : 94
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 540,
          "y" : 93
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 540,
          "y" : 93
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 3965,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 543,
          "y" : 109
        },
        "to" : {
          "x" : 625,
          "y" : 138
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 3965,
    "reactomeId" : 10904258,
    "displayName" : "JAK3 binds JAK3 inhibitors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 626,
      "y" : 138
    },
    "minX" : 620,
    "maxX" : 658,
    "minY" : 116,
    "maxY" : 144,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 625,
        "y" : 138
      },
      "to" : {
        "x" : 626,
        "y" : 138
      }
    }, {
      "from" : {
        "x" : 626,
        "y" : 138
      },
      "to" : {
        "x" : 658,
        "y" : 116
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 655,
        "y" : 123
      },
      "b" : {
        "x" : 658,
        "y" : 116
      },
      "c" : {
        "x" : 650,
        "y" : 117
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 650,
        "y" : 117
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 626,
        "y" : 138
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 626,
        "y" : 138
      }
    },
    "inputs" : [ {
      "id" : 3966,
      "points" : [ {
        "x" : 671,
        "y" : 165
      } ]
    }, {
      "id" : 3967,
      "points" : [ {
        "x" : 543,
        "y" : 109
      } ]
    } ],
    "outputs" : [ {
      "id" : 3968
    } ]
  } ],
  "compartments" : [ {
    "id" : 3969,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 768,
      "y" : 858
    },
    "minX" : 0,
    "maxX" : 1537,
    "minY" : 0,
    "maxY" : 1717,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1537,
      "height" : 1717
    },
    "textPosition" : {
      "x" : 359,
      "y" : 1049
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1517,
      "height" : 1697
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 3967, 3979, 3986, 3996, 3997, 3991, 3992, 3965, 3966, 3968 ]
  }, {
    "id" : 3979,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1093,
      "y" : 1163
    },
    "minX" : 1008,
    "maxX" : 1179,
    "minY" : 1082,
    "maxY" : 1244,
    "prop" : {
      "x" : 1008,
      "y" : 1082,
      "width" : 171,
      "height" : 162
    },
    "textPosition" : {
      "x" : 1024,
      "y" : 1198
    },
    "insets" : {
      "x" : 1018,
      "y" : 1092,
      "width" : 151,
      "height" : 142
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ {
    "id" : 3993,
    "reactomeId" : 10913320,
    "displayName" : "Interleukin-2 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 625,
      "y" : 142
    },
    "minX" : 494,
    "maxX" : 756,
    "minY" : 81,
    "maxY" : 204,
    "prop" : {
      "x" : 494,
      "y" : 81,
      "width" : 262,
      "height" : 123
    },
    "points" : [ {
      "x" : 494,
      "y" : 81
    }, {
      "x" : 756,
      "y" : 81
    }, {
      "x" : 756,
      "y" : 204
    }, {
      "x" : 494,
      "y" : 204
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 1537,
  "minY" : 0,
  "maxY" : 1717,
  "disease" : false
}