{
  "dbId" : 10912952,
  "stableId" : "R-DME-6805567",
  "displayName" : "Keratinization",
  "nodes" : [ {
    "id" : 41041,
    "reactomeId" : 171126,
    "displayName" : "TAGs",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1486,
      "y" : 886
    },
    "minX" : 1462,
    "maxX" : 1524,
    "minY" : 858,
    "maxY" : 901,
    "prop" : {
      "x" : 1462,
      "y" : 871,
      "width" : 48,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1466,
      "y" : 875
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1505,
          "y" : 876
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1505,
          "y" : 876
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 41040,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1506,
          "y" : 868
        },
        "to" : {
          "x" : 1524,
          "y" : 858
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 41042,
    "reactomeId" : 109276,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1481,
      "y" : 835
    },
    "minX" : 1460,
    "maxX" : 1524,
    "minY" : 819,
    "maxY" : 858,
    "prop" : {
      "x" : 1460,
      "y" : 820,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1464,
      "y" : 824
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1498,
          "y" : 825
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1498,
          "y" : 825
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 41040,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1506,
          "y" : 846
        },
        "to" : {
          "x" : 1524,
          "y" : 858
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 41043,
    "reactomeId" : 174675,
    "displayName" : "DAGs",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1600,
      "y" : 829
    },
    "minX" : 1567,
    "maxX" : 1626,
    "minY" : 813,
    "maxY" : 858,
    "prop" : {
      "x" : 1576,
      "y" : 814,
      "width" : 49,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1580,
      "y" : 818
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1620,
          "y" : 819
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1620,
          "y" : 819
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 41040,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1582,
          "y" : 847
        },
        "to" : {
          "x" : 1567,
          "y" : 858
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1579,
          "y" : 854
        },
        "b" : {
          "x" : 1582,
          "y" : 847
        },
        "c" : {
          "x" : 1574,
          "y" : 848
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1574,
          "y" : 848
        }
      }
    } ]
  }, {
    "id" : 41044,
    "reactomeId" : 6789319,
    "displayName" : "RCOOH",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1604,
      "y" : 887
    },
    "minX" : 1567,
    "maxX" : 1635,
    "minY" : 858,
    "maxY" : 902,
    "prop" : {
      "x" : 1574,
      "y" : 872,
      "width" : 60,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1578,
      "y" : 876
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1629,
          "y" : 877
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1629,
          "y" : 877
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 41040,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1584,
          "y" : 869
        },
        "to" : {
          "x" : 1567,
          "y" : 858
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1576,
          "y" : 869
        },
        "b" : {
          "x" : 1584,
          "y" : 869
        },
        "c" : {
          "x" : 1580,
          "y" : 862
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1580,
          "y" : 862
        }
      }
    } ]
  }, {
    "id" : 41045,
    "reactomeId" : 10886426,
    "displayName" : "keratinocyte LIPs",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1542,
      "y" : 795
    },
    "minX" : 1490,
    "maxX" : 1595,
    "minY" : 784,
    "maxY" : 851,
    "prop" : {
      "x" : 1490,
      "y" : 784,
      "width" : 105,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1497,
      "y" : 778
    },
    "connectors" : [ {
      "edgeId" : 41040,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1542,
          "y" : 812
        },
        "to" : {
          "x" : 1544,
          "y" : 843
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1544,
          "y" : 847
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1544,
          "y" : 847
        }
      }
    } ]
  }, {
    "id" : 41037,
    "reactomeId" : 10893251,
    "displayName" : "CG6982",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 27,
      "y" : 67
    },
    "minX" : 0,
    "maxX" : 79,
    "minY" : 48,
    "maxY" : 135,
    "prop" : {
      "x" : 0,
      "y" : 54,
      "width" : 55,
      "height" : 27
    },
    "textPosition" : {
      "x" : 3,
      "y" : 50
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 55,
          "y" : 54
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 55,
          "y" : 54
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 41036,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 37,
          "y" : 84
        },
        "to" : {
          "x" : 79,
          "y" : 135
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 41038,
    "reactomeId" : 10893267,
    "displayName" : "Desmosome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 133,
      "y" : 18
    },
    "minX" : 79,
    "maxX" : 189,
    "minY" : 0,
    "maxY" : 135,
    "prop" : {
      "x" : 84,
      "y" : 6,
      "width" : 99,
      "height" : 24
    },
    "textPosition" : {
      "x" : 91,
      "y" : 9
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 183,
          "y" : 6
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 183,
          "y" : 6
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 41036,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 127,
          "y" : 33
        },
        "to" : {
          "x" : 79,
          "y" : 135
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 41039,
    "reactomeId" : 10893269,
    "displayName" : "Desmosome:PERP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 122,
      "y" : 219
    },
    "minX" : 82,
    "maxX" : 168,
    "minY" : 196,
    "maxY" : 236,
    "prop" : {
      "x" : 82,
      "y" : 202,
      "width" : 80,
      "height" : 34
    },
    "textPosition" : {
      "x" : 83,
      "y" : 201
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 162,
          "y" : 202
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 162,
          "y" : 202
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 41036,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 41040,
    "reactomeId" : 10886429,
    "displayName" : "LIPs hydrolyse TG to DAG and RCOOH",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1545,
      "y" : 859
    },
    "minX" : 1524,
    "maxX" : 1567,
    "minY" : 853,
    "maxY" : 865,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1524,
        "y" : 858
      },
      "to" : {
        "x" : 1545,
        "y" : 859
      }
    }, {
      "from" : {
        "x" : 1545,
        "y" : 859
      },
      "to" : {
        "x" : 1567,
        "y" : 858
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1539,
        "y" : 853
      },
      "b" : {
        "x" : 1551,
        "y" : 865
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1545,
        "y" : 859
      }
    },
    "inputs" : [ {
      "id" : 41041,
      "points" : [ {
        "x" : 1506,
        "y" : 868
      } ]
    }, {
      "id" : 41042,
      "points" : [ {
        "x" : 1506,
        "y" : 846
      } ]
    } ],
    "outputs" : [ {
      "id" : 41043,
      "points" : [ {
        "x" : 1582,
        "y" : 847
      } ]
    }, {
      "id" : 41044,
      "points" : [ {
        "x" : 1584,
        "y" : 869
      } ]
    } ],
    "catalysts" : [ {
      "id" : 41045,
      "points" : [ {
        "x" : 1542,
        "y" : 812
      } ]
    } ]
  }, {
    "id" : 41036,
    "reactomeId" : 10893271,
    "displayName" : "PERP binds desmosomes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 78,
      "y" : 161
    },
    "minX" : 72,
    "maxX" : 109,
    "minY" : 135,
    "maxY" : 199,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 79,
        "y" : 135
      },
      "to" : {
        "x" : 78,
        "y" : 161
      }
    }, {
      "from" : {
        "x" : 78,
        "y" : 161
      },
      "to" : {
        "x" : 109,
        "y" : 199
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 102,
        "y" : 196
      },
      "b" : {
        "x" : 109,
        "y" : 199
      },
      "c" : {
        "x" : 108,
        "y" : 191
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 108,
        "y" : 191
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 78,
        "y" : 161
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 78,
        "y" : 161
      }
    },
    "inputs" : [ {
      "id" : 41037,
      "points" : [ {
        "x" : 37,
        "y" : 84
      } ]
    }, {
      "id" : 41038,
      "points" : [ {
        "x" : 127,
        "y" : 33
      } ]
    } ],
    "outputs" : [ {
      "id" : 41039
    } ]
  } ],
  "compartments" : [ {
    "id" : 41046,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 799,
      "y" : 382
    },
    "minX" : 126,
    "maxX" : 1473,
    "minY" : 11,
    "maxY" : 754,
    "prop" : {
      "x" : 126,
      "y" : 11,
      "width" : 1347,
      "height" : 743
    },
    "textPosition" : {
      "x" : 685,
      "y" : 626
    },
    "insets" : {
      "x" : 136,
      "y" : 21,
      "width" : 1327,
      "height" : 723
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 41055, 41056, 41057, 41059 ]
  }, {
    "id" : 41047,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 76,
      "y" : 386
    },
    "minX" : 26,
    "maxX" : 127,
    "minY" : 16,
    "maxY" : 756,
    "prop" : {
      "x" : 26,
      "y" : 16,
      "width" : 101,
      "height" : 740
    },
    "textPosition" : {
      "x" : 45,
      "y" : 688
    },
    "insets" : {
      "x" : 36,
      "y" : 26,
      "width" : 81,
      "height" : 720
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 41038, 41036, 41037, 41039 ]
  }, {
    "id" : 41049,
    "reactomeId" : 8847705,
    "displayName" : "cornified envelope",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1607,
      "y" : 381
    },
    "minX" : 1477,
    "maxX" : 1737,
    "minY" : 9,
    "maxY" : 754,
    "prop" : {
      "x" : 1477,
      "y" : 9,
      "width" : 260,
      "height" : 745
    },
    "textPosition" : {
      "x" : 1544,
      "y" : 365
    },
    "insets" : {
      "x" : 1487,
      "y" : 19,
      "width" : 240,
      "height" : 725
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ {
    "id" : 41050,
    "reactomeId" : 10912950,
    "displayName" : "Formation of the cornified envelope",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 817,
      "y" : 454
    },
    "minX" : -10,
    "maxX" : 1644,
    "minY" : -4,
    "maxY" : 912,
    "prop" : {
      "x" : -10,
      "y" : -4,
      "width" : 1654,
      "height" : 916
    },
    "points" : [ {
      "x" : -10,
      "y" : -4
    }, {
      "x" : 1644,
      "y" : -4
    }, {
      "x" : 1644,
      "y" : 912
    }, {
      "x" : -10,
      "y" : 912
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 1737,
  "minY" : 0,
  "maxY" : 902,
  "disease" : false
}