{
  "dbId" : 10912784,
  "stableId" : "R-DME-5632684",
  "displayName" : "Hedgehog 'on' state",
  "nodes" : [ {
    "id" : 128065,
    "reactomeId" : 10879773,
    "displayName" : "ADRBK1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 729,
      "y" : 638
    },
    "minX" : 599,
    "maxX" : 803,
    "minY" : 329,
    "maxY" : 649,
    "prop" : {
      "x" : 701,
      "y" : 627,
      "width" : 57,
      "height" : 22
    },
    "textPosition" : {
      "x" : 701,
      "y" : 627
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 758,
          "y" : 627
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 758,
          "y" : 627
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128061,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 734,
          "y" : 624
        },
        "to" : {
          "x" : 803,
          "y" : 491
        }
      }, {
        "from" : {
          "x" : 803,
          "y" : 491
        },
        "to" : {
          "x" : 599,
          "y" : 329
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 734,
          "y" : 616
        },
        "b" : {
          "x" : 734,
          "y" : 624
        },
        "c" : {
          "x" : 741,
          "y" : 620
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 741,
          "y" : 620
        }
      }
    } ]
  }, {
    "id" : 128064,
    "reactomeId" : 10879786,
    "displayName" : "p6S, T-SMO dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 598,
      "y" : 293
    },
    "minX" : 540,
    "maxX" : 663,
    "minY" : 276,
    "maxY" : 329,
    "prop" : {
      "x" : 540,
      "y" : 282,
      "width" : 117,
      "height" : 22
    },
    "textPosition" : {
      "x" : 540,
      "y" : 283
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 657,
          "y" : 282
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 657,
          "y" : 282
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128061,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 598,
          "y" : 307
        },
        "to" : {
          "x" : 599,
          "y" : 329
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 602,
          "y" : 314
        },
        "b" : {
          "x" : 598,
          "y" : 307
        },
        "c" : {
          "x" : 594,
          "y" : 314
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 594,
          "y" : 314
        }
      }
    } ]
  }, {
    "id" : 128067,
    "reactomeId" : 10878577,
    "displayName" : "Su(fu)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 997,
      "y" : 1059
    },
    "minX" : 966,
    "maxX" : 1047,
    "minY" : 1039,
    "maxY" : 1089,
    "prop" : {
      "x" : 966,
      "y" : 1045,
      "width" : 62,
      "height" : 28
    },
    "textPosition" : {
      "x" : 974,
      "y" : 1048
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1028,
          "y" : 1045
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1028,
          "y" : 1045
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128066,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1020,
          "y" : 1076
        },
        "to" : {
          "x" : 1047,
          "y" : 1089
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128069,
    "reactomeId" : 10878579,
    "displayName" : "GLI:SUFU",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1158,
      "y" : 1091
    },
    "minX" : 1123,
    "maxX" : 1200,
    "minY" : 1072,
    "maxY" : 1104,
    "prop" : {
      "x" : 1123,
      "y" : 1078,
      "width" : 71,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1127,
      "y" : 1083
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1194,
          "y" : 1078
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1194,
          "y" : 1078
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128066,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128068,
    "reactomeId" : 10878571,
    "displayName" : "ci",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1000,
      "y" : 1118
    },
    "minX" : 959,
    "maxX" : 1047,
    "minY" : 1089,
    "maxY" : 1130,
    "prop" : {
      "x" : 959,
      "y" : 1106,
      "width" : 82,
      "height" : 24
    },
    "textPosition" : {
      "x" : 991,
      "y" : 1107
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1041,
          "y" : 1106
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1041,
          "y" : 1106
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128066,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1019,
          "y" : 1100
        },
        "to" : {
          "x" : 1047,
          "y" : 1089
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128071,
    "reactomeId" : 10879832,
    "displayName" : "phospho-ci",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1295,
      "y" : 321
    },
    "minX" : 1235,
    "maxX" : 1361,
    "minY" : 228,
    "maxY" : 339,
    "prop" : {
      "x" : 1235,
      "y" : 303,
      "width" : 120,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1256,
      "y" : 310
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1355,
          "y" : 303
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1355,
          "y" : 303
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128080,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1294,
          "y" : 297
        },
        "to" : {
          "x" : 1291,
          "y" : 228
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1290,
          "y" : 290
        },
        "b" : {
          "x" : 1294,
          "y" : 297
        },
        "c" : {
          "x" : 1298,
          "y" : 290
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1298,
          "y" : 290
        }
      }
    }, {
      "edgeId" : 128070,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128072,
    "reactomeId" : 10879820,
    "displayName" : "phospho-ci",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1385,
      "y" : 1260
    },
    "minX" : 1342,
    "maxX" : 1434,
    "minY" : 1240,
    "maxY" : 1274,
    "prop" : {
      "x" : 1342,
      "y" : 1246,
      "width" : 86,
      "height" : 28
    },
    "textPosition" : {
      "x" : 1346,
      "y" : 1249
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1428,
          "y" : 1246
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1428,
          "y" : 1246
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128070,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128075,
    "reactomeId" : 10840121,
    "displayName" : "Smurf",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 186,
      "y" : 1048
    },
    "minX" : 161,
    "maxX" : 411,
    "minY" : 921,
    "maxY" : 1127,
    "prop" : {
      "x" : 161,
      "y" : 1037,
      "width" : 51,
      "height" : 22
    },
    "textPosition" : {
      "x" : 164,
      "y" : 1037
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 212,
          "y" : 1037
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 212,
          "y" : 1037
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128073,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 202,
          "y" : 1065
        },
        "to" : {
          "x" : 305,
          "y" : 1127
        }
      }, {
        "from" : {
          "x" : 305,
          "y" : 1127
        },
        "to" : {
          "x" : 379,
          "y" : 949
        }
      }, {
        "from" : {
          "x" : 379,
          "y" : 949
        },
        "to" : {
          "x" : 411,
          "y" : 921
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 210,
          "y" : 1065
        },
        "b" : {
          "x" : 202,
          "y" : 1065
        },
        "c" : {
          "x" : 206,
          "y" : 1072
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 206,
          "y" : 1072
        }
      }
    } ]
  }, {
    "id" : 128074,
    "reactomeId" : 10879896,
    "displayName" : "ub-PTCH1:SMURF",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 420,
      "y" : 865
    },
    "minX" : 378,
    "maxX" : 469,
    "minY" : 841,
    "maxY" : 884,
    "prop" : {
      "x" : 378,
      "y" : 847,
      "width" : 85,
      "height" : 37
    },
    "textPosition" : {
      "x" : 384,
      "y" : 849
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 463,
          "y" : 847
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 463,
          "y" : 847
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128073,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128077,
    "reactomeId" : 10879815,
    "displayName" : "ULK3:SUFU",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 974,
      "y" : 61
    },
    "minX" : 921,
    "maxX" : 1033,
    "minY" : 37,
    "maxY" : 80,
    "prop" : {
      "x" : 921,
      "y" : 43,
      "width" : 106,
      "height" : 37
    },
    "textPosition" : {
      "x" : 936,
      "y" : 59
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1027,
          "y" : 43
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1027,
          "y" : 43
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128076,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128079,
    "reactomeId" : 10879813,
    "displayName" : "Aduk",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1263,
      "y" : 87
    },
    "minX" : 1075,
    "maxX" : 1289,
    "minY" : 70,
    "maxY" : 194,
    "prop" : {
      "x" : 1243,
      "y" : 76,
      "width" : 40,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1243,
      "y" : 76
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1283,
          "y" : 76
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1283,
          "y" : 76
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128080,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1265,
          "y" : 101
        },
        "to" : {
          "x" : 1284,
          "y" : 186
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1284,
          "y" : 190
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1284,
          "y" : 190
        }
      }
    }, {
      "edgeId" : 128076,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1240,
          "y" : 89
        },
        "to" : {
          "x" : 1075,
          "y" : 113
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1234,
          "y" : 94
        },
        "b" : {
          "x" : 1240,
          "y" : 89
        },
        "c" : {
          "x" : 1233,
          "y" : 86
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1233,
          "y" : 86
        }
      }
    } ]
  }, {
    "id" : 128078,
    "reactomeId" : 10878677,
    "displayName" : "Su(fu)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1100,
      "y" : 210
    },
    "minX" : 1075,
    "maxX" : 1127,
    "minY" : 113,
    "maxY" : 221,
    "prop" : {
      "x" : 1079,
      "y" : 199,
      "width" : 42,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1085,
      "y" : 193
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1121,
          "y" : 199
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1121,
          "y" : 199
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128076,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1097,
          "y" : 196
        },
        "to" : {
          "x" : 1075,
          "y" : 113
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1091,
          "y" : 190
        },
        "b" : {
          "x" : 1097,
          "y" : 196
        },
        "c" : {
          "x" : 1099,
          "y" : 188
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1099,
          "y" : 188
        }
      }
    } ]
  }, {
    "id" : 128081,
    "reactomeId" : 10878671,
    "displayName" : "ci",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1175,
      "y" : 199
    },
    "minX" : 1138,
    "maxX" : 1253,
    "minY" : 181,
    "maxY" : 212,
    "prop" : {
      "x" : 1138,
      "y" : 187,
      "width" : 74,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1166,
      "y" : 189
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1212,
          "y" : 187
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1212,
          "y" : 187
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128080,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1218,
          "y" : 198
        },
        "to" : {
          "x" : 1253,
          "y" : 197
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128083,
    "reactomeId" : 5632457,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1238,
      "y" : 270
    },
    "minX" : 1217,
    "maxX" : 1291,
    "minY" : 228,
    "maxY" : 285,
    "prop" : {
      "x" : 1217,
      "y" : 255,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1221,
      "y" : 259
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1254,
          "y" : 260
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1254,
          "y" : 260
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128080,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1256,
          "y" : 252
        },
        "to" : {
          "x" : 1291,
          "y" : 228
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1259,
          "y" : 245
        },
        "b" : {
          "x" : 1256,
          "y" : 252
        },
        "c" : {
          "x" : 1264,
          "y" : 251
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1264,
          "y" : 251
        }
      }
    } ]
  }, {
    "id" : 128082,
    "reactomeId" : 5632460,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1220,
      "y" : 156
    },
    "minX" : 1200,
    "maxX" : 1253,
    "minY" : 140,
    "maxY" : 197,
    "prop" : {
      "x" : 1200,
      "y" : 141,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1204,
      "y" : 145
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1235,
          "y" : 146
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1235,
          "y" : 146
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128080,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1232,
          "y" : 174
        },
        "to" : {
          "x" : 1253,
          "y" : 197
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128085,
    "reactomeId" : 10836849,
    "displayName" : "hyx",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1572,
      "y" : 1143
    },
    "minX" : 1543,
    "maxX" : 1656,
    "minY" : 1126,
    "maxY" : 1154,
    "prop" : {
      "x" : 1543,
      "y" : 1132,
      "width" : 59,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1558,
      "y" : 1132
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1602,
          "y" : 1132
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1602,
          "y" : 1132
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128084,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1605,
          "y" : 1142
        },
        "to" : {
          "x" : 1656,
          "y" : 1142
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128087,
    "reactomeId" : 10879843,
    "displayName" : "CDC73:2p-GLI",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1784,
      "y" : 1142
    },
    "minX" : 1747,
    "maxX" : 1827,
    "minY" : 1115,
    "maxY" : 1163,
    "prop" : {
      "x" : 1747,
      "y" : 1121,
      "width" : 74,
      "height" : 42
    },
    "textPosition" : {
      "x" : 1747,
      "y" : 1128
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1821,
          "y" : 1121
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1821,
          "y" : 1121
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128084,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128086,
    "reactomeId" : 10879826,
    "displayName" : "phospho-ci",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1594,
      "y" : 1256
    },
    "minX" : 1538,
    "maxX" : 1657,
    "minY" : 1142,
    "maxY" : 1273,
    "prop" : {
      "x" : 1538,
      "y" : 1240,
      "width" : 113,
      "height" : 33
    },
    "textPosition" : {
      "x" : 1556,
      "y" : 1246
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1651,
          "y" : 1240
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1651,
          "y" : 1240
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128084,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1602,
          "y" : 1234
        },
        "to" : {
          "x" : 1656,
          "y" : 1142
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128089,
    "reactomeId" : 10879877,
    "displayName" : "SPOP:CUL3:RBX1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1388,
      "y" : 1709
    },
    "minX" : 1332,
    "maxX" : 1883,
    "minY" : 1692,
    "maxY" : 1819,
    "prop" : {
      "x" : 1332,
      "y" : 1698,
      "width" : 112,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1332,
      "y" : 1699
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1444,
          "y" : 1698
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1444,
          "y" : 1698
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128096,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1390,
          "y" : 1723
        },
        "to" : {
          "x" : 1412,
          "y" : 1819
        }
      }, {
        "from" : {
          "x" : 1412,
          "y" : 1819
        },
        "to" : {
          "x" : 1883,
          "y" : 1814
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1395,
          "y" : 1729
        },
        "b" : {
          "x" : 1390,
          "y" : 1723
        },
        "c" : {
          "x" : 1388,
          "y" : 1731
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1388,
          "y" : 1731
        }
      }
    }, {
      "edgeId" : 128088,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1447,
          "y" : 1705
        },
        "to" : {
          "x" : 1482,
          "y" : 1703
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128091,
    "reactomeId" : 10879883,
    "displayName" : "2p-GLI:SPOP:CUL3:RBX1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1586,
      "y" : 1703
    },
    "minX" : 1545,
    "maxX" : 1692,
    "minY" : 1673,
    "maxY" : 1728,
    "prop" : {
      "x" : 1545,
      "y" : 1679,
      "width" : 83,
      "height" : 49
    },
    "textPosition" : {
      "x" : 1546,
      "y" : 1679
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1628,
          "y" : 1679
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1628,
          "y" : 1679
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128088,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 128093,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1631,
          "y" : 1703
        },
        "to" : {
          "x" : 1670,
          "y" : 1703
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 128093,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1631,
          "y" : 1687
        },
        "to" : {
          "x" : 1663,
          "y" : 1674
        }
      }, {
        "from" : {
          "x" : 1663,
          "y" : 1674
        },
        "to" : {
          "x" : 1685,
          "y" : 1692
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1688,
          "y" : 1694
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1688,
          "y" : 1694
        }
      }
    } ]
  }, {
    "id" : 128090,
    "reactomeId" : 10879828,
    "displayName" : "phospho-ci",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1369,
      "y" : 1500
    },
    "minX" : 1335,
    "maxX" : 1482,
    "minY" : 1483,
    "maxY" : 1703,
    "prop" : {
      "x" : 1335,
      "y" : 1489,
      "width" : 69,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1336,
      "y" : 1483
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1404,
          "y" : 1489
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1404,
          "y" : 1489
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128088,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1375,
          "y" : 1517
        },
        "to" : {
          "x" : 1482,
          "y" : 1703
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128092,
    "reactomeId" : 10879888,
    "displayName" : "DZIP1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1508,
      "y" : 1766
    },
    "minX" : 1472,
    "maxX" : 1551,
    "minY" : 1711,
    "maxY" : 1779,
    "prop" : {
      "x" : 1472,
      "y" : 1754,
      "width" : 73,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1486,
      "y" : 1756
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1545,
          "y" : 1754
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1545,
          "y" : 1754
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128088,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 1507,
          "y" : 1751
        },
        "to" : {
          "x" : 1505,
          "y" : 1711
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1509,
          "y" : 1718
        },
        "b" : {
          "x" : 1505,
          "y" : 1711
        },
        "c" : {
          "x" : 1501,
          "y" : 1718
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 1501,
          "y" : 1718
        }
      }
    } ]
  }, {
    "id" : 128095,
    "reactomeId" : 10879879,
    "displayName" : "ub-2p-GLI2,3:SPOP:CUL3:RBX1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1788,
      "y" : 1702
    },
    "minX" : 1729,
    "maxX" : 1854,
    "minY" : 1671,
    "maxY" : 1727,
    "prop" : {
      "x" : 1729,
      "y" : 1677,
      "width" : 119,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1733,
      "y" : 1692
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1848,
          "y" : 1677
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1848,
          "y" : 1677
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128096,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 128093,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128094,
    "reactomeId" : 10829355,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1652,
      "y" : 1756
    },
    "minX" : 1621,
    "maxX" : 1883,
    "minY" : 1703,
    "maxY" : 1814,
    "prop" : {
      "x" : 1621,
      "y" : 1745,
      "width" : 62,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1639,
      "y" : 1745
    },
    "connectors" : [ {
      "edgeId" : 128096,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1689,
          "y" : 1763
        },
        "to" : {
          "x" : 1883,
          "y" : 1814
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1697,
          "y" : 1761
        },
        "b" : {
          "x" : 1689,
          "y" : 1763
        },
        "c" : {
          "x" : 1695,
          "y" : 1769
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1695,
          "y" : 1769
        }
      }
    }, {
      "edgeId" : 128093,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1655,
          "y" : 1739
        },
        "to" : {
          "x" : 1670,
          "y" : 1703
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128097,
    "reactomeId" : 10829617,
    "displayName" : "26S proteasome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1931,
      "y" : 1669
    },
    "minX" : 1875,
    "maxX" : 1994,
    "minY" : 1652,
    "maxY" : 1703,
    "prop" : {
      "x" : 1875,
      "y" : 1658,
      "width" : 113,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1875,
      "y" : 1659
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1988,
          "y" : 1658
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1988,
          "y" : 1658
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128096,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1916,
          "y" : 1683
        },
        "to" : {
          "x" : 1894,
          "y" : 1697
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1891,
          "y" : 1699
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1891,
          "y" : 1699
        }
      }
    } ]
  }, {
    "id" : 128114,
    "reactomeId" : 10879826,
    "displayName" : "phospho-ci",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1493,
      "y" : 1522
    },
    "minX" : 1462,
    "maxX" : 1531,
    "minY" : 1500,
    "maxY" : 1539,
    "prop" : {
      "x" : 1462,
      "y" : 1506,
      "width" : 63,
      "height" : 33
    },
    "textPosition" : {
      "x" : 1462,
      "y" : 1505
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1525,
          "y" : 1506
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1525,
          "y" : 1506
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 128055,
    "reactomeId" : 10879733,
    "displayName" : "Hh-Npp",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 30,
      "y" : 609
    },
    "minX" : 0,
    "maxX" : 334,
    "minY" : 562,
    "maxY" : 620,
    "prop" : {
      "x" : 0,
      "y" : 598,
      "width" : 61,
      "height" : 22
    },
    "textPosition" : {
      "x" : 3,
      "y" : 598
    },
    "connectors" : [ {
      "edgeId" : 128053,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 67,
          "y" : 604
        },
        "to" : {
          "x" : 334,
          "y" : 562
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128054,
    "reactomeId" : 10847920,
    "displayName" : "fra",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 421,
      "y" : 588
    },
    "minX" : 334,
    "maxX" : 454,
    "minY" : 562,
    "maxY" : 600,
    "prop" : {
      "x" : 394,
      "y" : 577,
      "width" : 54,
      "height" : 23
    },
    "textPosition" : {
      "x" : 408,
      "y" : 578
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 448,
          "y" : 577
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 448,
          "y" : 577
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128053,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 391,
          "y" : 579
        },
        "to" : {
          "x" : 334,
          "y" : 562
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128057,
    "reactomeId" : 10879735,
    "displayName" : "Hh-Npp:CDON:PTCH",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 430,
      "y" : 511
    },
    "minX" : 388,
    "maxX" : 478,
    "minY" : 487,
    "maxY" : 530,
    "prop" : {
      "x" : 388,
      "y" : 493,
      "width" : 84,
      "height" : 37
    },
    "textPosition" : {
      "x" : 390,
      "y" : 495
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 472,
          "y" : 493
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 472,
          "y" : 493
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128053,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128056,
    "reactomeId" : 10878666,
    "displayName" : "ptc",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 407,
      "y" : 638
    },
    "minX" : 334,
    "maxX" : 450,
    "minY" : 562,
    "maxY" : 652,
    "prop" : {
      "x" : 370,
      "y" : 625,
      "width" : 74,
      "height" : 27
    },
    "textPosition" : {
      "x" : 393,
      "y" : 628
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 444,
          "y" : 625
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 444,
          "y" : 625
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128053,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 394,
          "y" : 622
        },
        "to" : {
          "x" : 334,
          "y" : 562
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128059,
    "reactomeId" : 10879746,
    "displayName" : "ptc",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 417,
      "y" : 976
    },
    "minX" : 387,
    "maxX" : 453,
    "minY" : 921,
    "maxY" : 993,
    "prop" : {
      "x" : 387,
      "y" : 959,
      "width" : 60,
      "height" : 34
    },
    "textPosition" : {
      "x" : 403,
      "y" : 965
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 447,
          "y" : 959
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 447,
          "y" : 959
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128073,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 415,
          "y" : 956
        },
        "to" : {
          "x" : 411,
          "y" : 921
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 410,
          "y" : 950
        },
        "b" : {
          "x" : 415,
          "y" : 956
        },
        "c" : {
          "x" : 418,
          "y" : 949
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 418,
          "y" : 949
        }
      }
    }, {
      "edgeId" : 128058,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128060,
    "reactomeId" : 10879748,
    "displayName" : "ptc",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 433,
      "y" : 1320
    },
    "minX" : 401,
    "maxX" : 472,
    "minY" : 1295,
    "maxY" : 1340,
    "prop" : {
      "x" : 401,
      "y" : 1301,
      "width" : 65,
      "height" : 39
    },
    "textPosition" : {
      "x" : 419,
      "y" : 1310
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 466,
          "y" : 1301
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 466,
          "y" : 1301
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128058,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 128063,
    "reactomeId" : 10879775,
    "displayName" : "CSNK1A1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 720,
      "y" : 930
    },
    "minX" : 599,
    "maxX" : 848,
    "minY" : 329,
    "maxY" : 943,
    "prop" : {
      "x" : 676,
      "y" : 917,
      "width" : 88,
      "height" : 26
    },
    "textPosition" : {
      "x" : 688,
      "y" : 919
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 764,
          "y" : 917
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 764,
          "y" : 917
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128061,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 723,
          "y" : 914
        },
        "to" : {
          "x" : 848,
          "y" : 484
        }
      }, {
        "from" : {
          "x" : 848,
          "y" : 484
        },
        "to" : {
          "x" : 599,
          "y" : 329
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 721,
          "y" : 906
        },
        "b" : {
          "x" : 723,
          "y" : 914
        },
        "c" : {
          "x" : 729,
          "y" : 908
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 729,
          "y" : 908
        }
      }
    } ]
  }, {
    "id" : 128062,
    "reactomeId" : 10879788,
    "displayName" : "p6S, T-SMO dimer:CSNK1A1:ADRBK1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 605,
      "y" : 401
    },
    "minX" : 545,
    "maxX" : 672,
    "minY" : 377,
    "maxY" : 419,
    "prop" : {
      "x" : 545,
      "y" : 383,
      "width" : 121,
      "height" : 36
    },
    "textPosition" : {
      "x" : 545,
      "y" : 384
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 666,
          "y" : 383
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 666,
          "y" : 383
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 128061,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 128080,
    "reactomeId" : 10879839,
    "displayName" : "ULK3 phosphorylates GLI",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1287,
      "y" : 202
    },
    "minX" : 1253,
    "maxX" : 1293,
    "minY" : 196,
    "maxY" : 228,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1253,
        "y" : 197
      },
      "to" : {
        "x" : 1287,
        "y" : 202
      }
    }, {
      "from" : {
        "x" : 1287,
        "y" : 202
      },
      "to" : {
        "x" : 1291,
        "y" : 228
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1281,
        "y" : 196
      },
      "b" : {
        "x" : 1293,
        "y" : 208
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1287,
        "y" : 202
      }
    },
    "inputs" : [ {
      "id" : 128081,
      "points" : [ {
        "x" : 1218,
        "y" : 198
      } ]
    }, {
      "id" : 128082,
      "points" : [ {
        "x" : 1232,
        "y" : 174
      } ]
    } ],
    "outputs" : [ {
      "id" : 128083,
      "points" : [ {
        "x" : 1256,
        "y" : 252
      } ]
    }, {
      "id" : 128071,
      "points" : [ {
        "x" : 1294,
        "y" : 297
      } ]
    } ],
    "catalysts" : [ {
      "id" : 128079,
      "points" : [ {
        "x" : 1265,
        "y" : 101
      } ]
    } ]
  }, {
    "id" : 128096,
    "reactomeId" : 10879881,
    "displayName" : "GLI2,3 are degraded by the proteasome",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1881,
      "y" : 1706
    },
    "minX" : 1851,
    "maxX" : 1887,
    "minY" : 1700,
    "maxY" : 1814,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1851,
        "y" : 1704
      },
      "to" : {
        "x" : 1881,
        "y" : 1706
      }
    }, {
      "from" : {
        "x" : 1881,
        "y" : 1706
      },
      "to" : {
        "x" : 1883,
        "y" : 1814
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1875,
        "y" : 1700
      },
      "b" : {
        "x" : 1887,
        "y" : 1712
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1881,
        "y" : 1706
      }
    },
    "inputs" : [ {
      "id" : 128095
    } ],
    "outputs" : [ {
      "id" : 128089,
      "points" : [ {
        "x" : 1390,
        "y" : 1723
      }, {
        "x" : 1412,
        "y" : 1819
      } ]
    }, {
      "id" : 128094,
      "points" : [ {
        "x" : 1689,
        "y" : 1763
      } ]
    } ],
    "catalysts" : [ {
      "id" : 128097,
      "points" : [ {
        "x" : 1916,
        "y" : 1683
      } ]
    } ]
  }, {
    "id" : 128066,
    "reactomeId" : 10878581,
    "displayName" : "GLI proteins bind SUFU",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1080,
      "y" : 1091
    },
    "minX" : 1047,
    "maxX" : 1120,
    "minY" : 1085,
    "maxY" : 1097,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1047,
        "y" : 1089
      },
      "to" : {
        "x" : 1080,
        "y" : 1091
      }
    }, {
      "from" : {
        "x" : 1080,
        "y" : 1091
      },
      "to" : {
        "x" : 1120,
        "y" : 1091
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1113,
        "y" : 1095
      },
      "b" : {
        "x" : 1120,
        "y" : 1091
      },
      "c" : {
        "x" : 1113,
        "y" : 1087
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1113,
        "y" : 1087
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1080,
        "y" : 1091
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1080,
        "y" : 1091
      }
    },
    "inputs" : [ {
      "id" : 128067,
      "points" : [ {
        "x" : 1020,
        "y" : 1076
      } ]
    }, {
      "id" : 128068,
      "points" : [ {
        "x" : 1019,
        "y" : 1100
      } ]
    } ],
    "outputs" : [ {
      "id" : 128069
    } ]
  }, {
    "id" : 128053,
    "reactomeId" : 10879737,
    "displayName" : "Hh-Npp binds CDON and PTCH",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 336,
      "y" : 520
    },
    "minX" : 330,
    "maxX" : 385,
    "minY" : 514,
    "maxY" : 562,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 334,
        "y" : 562
      },
      "to" : {
        "x" : 336,
        "y" : 520
      }
    }, {
      "from" : {
        "x" : 336,
        "y" : 520
      },
      "to" : {
        "x" : 385,
        "y" : 515
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 379,
        "y" : 520
      },
      "b" : {
        "x" : 385,
        "y" : 515
      },
      "c" : {
        "x" : 378,
        "y" : 512
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 378,
        "y" : 512
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 336,
        "y" : 520
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 336,
        "y" : 520
      }
    },
    "inputs" : [ {
      "id" : 128054,
      "points" : [ {
        "x" : 391,
        "y" : 579
      } ]
    }, {
      "id" : 128055,
      "points" : [ {
        "x" : 67,
        "y" : 604
      } ]
    }, {
      "id" : 128056,
      "points" : [ {
        "x" : 394,
        "y" : 622
      } ]
    } ],
    "outputs" : [ {
      "id" : 128057
    } ]
  }, {
    "id" : 128084,
    "reactomeId" : 10879845,
    "displayName" : "GLI proteins bind CDC73",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1685,
      "y" : 1143
    },
    "minX" : 1656,
    "maxX" : 1744,
    "minY" : 1137,
    "maxY" : 1149,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1656,
        "y" : 1142
      },
      "to" : {
        "x" : 1685,
        "y" : 1143
      }
    }, {
      "from" : {
        "x" : 1685,
        "y" : 1143
      },
      "to" : {
        "x" : 1744,
        "y" : 1142
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1737,
        "y" : 1146
      },
      "b" : {
        "x" : 1744,
        "y" : 1142
      },
      "c" : {
        "x" : 1737,
        "y" : 1138
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1737,
        "y" : 1138
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1685,
        "y" : 1143
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1685,
        "y" : 1143
      }
    },
    "inputs" : [ {
      "id" : 128085,
      "points" : [ {
        "x" : 1605,
        "y" : 1142
      } ]
    }, {
      "id" : 128086,
      "points" : [ {
        "x" : 1602,
        "y" : 1234
      } ]
    } ],
    "outputs" : [ {
      "id" : 128087
    } ]
  }, {
    "id" : 128070,
    "reactomeId" : 10879841,
    "displayName" : "GLI translocates to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1312,
      "y" : 514
    },
    "minX" : 1296,
    "maxX" : 1383,
    "minY" : 345,
    "maxY" : 1240,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1296,
        "y" : 345
      },
      "to" : {
        "x" : 1312,
        "y" : 514
      }
    }, {
      "from" : {
        "x" : 1312,
        "y" : 514
      },
      "to" : {
        "x" : 1383,
        "y" : 1240
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1378,
        "y" : 1233
      },
      "b" : {
        "x" : 1383,
        "y" : 1240
      },
      "c" : {
        "x" : 1386,
        "y" : 1233
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1386,
        "y" : 1233
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1306,
        "y" : 508
      },
      "b" : {
        "x" : 1318,
        "y" : 520
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1312,
        "y" : 514
      }
    },
    "inputs" : [ {
      "id" : 128071
    } ],
    "outputs" : [ {
      "id" : 128072
    } ]
  }, {
    "id" : 128073,
    "reactomeId" : 10879898,
    "displayName" : "SMURF1/2 dissociates from ub-PTCH1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 412,
      "y" : 901
    },
    "minX" : 406,
    "maxX" : 418,
    "minY" : 887,
    "maxY" : 921,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 415,
        "y" : 887
      },
      "to" : {
        "x" : 412,
        "y" : 901
      }
    }, {
      "from" : {
        "x" : 412,
        "y" : 901
      },
      "to" : {
        "x" : 411,
        "y" : 921
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 412,
        "y" : 901
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 412,
        "y" : 901
      }
    },
    "inputs" : [ {
      "id" : 128074
    } ],
    "outputs" : [ {
      "id" : 128075,
      "points" : [ {
        "x" : 202,
        "y" : 1065
      }, {
        "x" : 305,
        "y" : 1127
      }, {
        "x" : 379,
        "y" : 949
      } ]
    }, {
      "id" : 128059,
      "points" : [ {
        "x" : 415,
        "y" : 956
      } ]
    } ]
  }, {
    "id" : 128088,
    "reactomeId" : 10879890,
    "displayName" : "phosphorylated GLI proteins bind SPOP:CUL3:RBX1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1505,
      "y" : 1702
    },
    "minX" : 1482,
    "maxX" : 1542,
    "minY" : 1696,
    "maxY" : 1708,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1482,
        "y" : 1703
      },
      "to" : {
        "x" : 1505,
        "y" : 1702
      }
    }, {
      "from" : {
        "x" : 1505,
        "y" : 1702
      },
      "to" : {
        "x" : 1542,
        "y" : 1702
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1535,
        "y" : 1706
      },
      "b" : {
        "x" : 1542,
        "y" : 1702
      },
      "c" : {
        "x" : 1535,
        "y" : 1698
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1535,
        "y" : 1698
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1505,
        "y" : 1702
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1505,
        "y" : 1702
      }
    },
    "inputs" : [ {
      "id" : 128089,
      "points" : [ {
        "x" : 1447,
        "y" : 1705
      } ]
    }, {
      "id" : 128090,
      "points" : [ {
        "x" : 1375,
        "y" : 1517
      } ]
    } ],
    "outputs" : [ {
      "id" : 128091
    } ],
    "activators" : [ {
      "id" : 128092,
      "points" : [ {
        "x" : 1507,
        "y" : 1751
      } ]
    } ]
  }, {
    "id" : 128058,
    "reactomeId" : 10879750,
    "displayName" : "PTCH is internalized",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 427,
      "y" : 1109
    },
    "minX" : 418,
    "maxX" : 433,
    "minY" : 996,
    "maxY" : 1298,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 418,
        "y" : 996
      },
      "to" : {
        "x" : 427,
        "y" : 1109
      }
    }, {
      "from" : {
        "x" : 427,
        "y" : 1109
      },
      "to" : {
        "x" : 432,
        "y" : 1298
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 428,
        "y" : 1291
      },
      "b" : {
        "x" : 432,
        "y" : 1298
      },
      "c" : {
        "x" : 436,
        "y" : 1291
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 436,
        "y" : 1291
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 421,
        "y" : 1103
      },
      "b" : {
        "x" : 433,
        "y" : 1115
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 427,
        "y" : 1109
      }
    },
    "inputs" : [ {
      "id" : 128059
    } ],
    "outputs" : [ {
      "id" : 128060
    } ]
  }, {
    "id" : 128093,
    "reactomeId" : 10879894,
    "displayName" : "SPOP:CUL3:RBX1 ubiquitinates GLI2,3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1697,
      "y" : 1702
    },
    "minX" : 1670,
    "maxX" : 1726,
    "minY" : 1696,
    "maxY" : 1708,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1670,
        "y" : 1703
      },
      "to" : {
        "x" : 1697,
        "y" : 1702
      }
    }, {
      "from" : {
        "x" : 1697,
        "y" : 1702
      },
      "to" : {
        "x" : 1726,
        "y" : 1702
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1719,
        "y" : 1706
      },
      "b" : {
        "x" : 1726,
        "y" : 1702
      },
      "c" : {
        "x" : 1719,
        "y" : 1698
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1719,
        "y" : 1698
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1691,
        "y" : 1696
      },
      "b" : {
        "x" : 1703,
        "y" : 1708
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1697,
        "y" : 1702
      }
    },
    "inputs" : [ {
      "id" : 128091,
      "points" : [ {
        "x" : 1631,
        "y" : 1703
      } ]
    }, {
      "id" : 128094,
      "points" : [ {
        "x" : 1655,
        "y" : 1739
      } ]
    } ],
    "outputs" : [ {
      "id" : 128095
    } ],
    "catalysts" : [ {
      "id" : 128091,
      "points" : [ {
        "x" : 1631,
        "y" : 1687
      }, {
        "x" : 1663,
        "y" : 1674
      } ]
    } ]
  }, {
    "id" : 128061,
    "reactomeId" : 10879790,
    "displayName" : "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 597,
      "y" : 355
    },
    "minX" : 591,
    "maxX" : 603,
    "minY" : 329,
    "maxY" : 380,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 601,
        "y" : 380
      },
      "to" : {
        "x" : 597,
        "y" : 355
      }
    }, {
      "from" : {
        "x" : 597,
        "y" : 355
      },
      "to" : {
        "x" : 599,
        "y" : 329
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 597,
        "y" : 355
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 597,
        "y" : 355
      }
    },
    "inputs" : [ {
      "id" : 128062
    } ],
    "outputs" : [ {
      "id" : 128063,
      "points" : [ {
        "x" : 723,
        "y" : 914
      }, {
        "x" : 848,
        "y" : 484
      } ]
    }, {
      "id" : 128064,
      "points" : [ {
        "x" : 598,
        "y" : 307
      } ]
    }, {
      "id" : 128065,
      "points" : [ {
        "x" : 734,
        "y" : 624
      }, {
        "x" : 803,
        "y" : 491
      } ]
    } ]
  }, {
    "id" : 128076,
    "reactomeId" : 10879817,
    "displayName" : "ULK3:SUFU dissociates",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1045,
      "y" : 98
    },
    "minX" : 1009,
    "maxX" : 1075,
    "minY" : 83,
    "maxY" : 113,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 1009,
        "y" : 83
      },
      "to" : {
        "x" : 1045,
        "y" : 98
      }
    }, {
      "from" : {
        "x" : 1045,
        "y" : 98
      },
      "to" : {
        "x" : 1075,
        "y" : 113
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 1045,
        "y" : 98
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 1045,
        "y" : 98
      }
    },
    "inputs" : [ {
      "id" : 128077
    } ],
    "outputs" : [ {
      "id" : 128078,
      "points" : [ {
        "x" : 1097,
        "y" : 196
      } ]
    }, {
      "id" : 128079,
      "points" : [ {
        "x" : 1240,
        "y" : 89
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 128099,
    "reactomeId" : 528865,
    "displayName" : "endocytic vesicle lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 707,
      "y" : 1360
    },
    "minX" : 412,
    "maxX" : 1002,
    "minY" : 1268,
    "maxY" : 1453,
    "prop" : {
      "x" : 412,
      "y" : 1268,
      "width" : 590,
      "height" : 185
    },
    "textPosition" : {
      "x" : 764,
      "y" : 1374
    },
    "insets" : {
      "x" : 422,
      "y" : 1278,
      "width" : 570,
      "height" : 165
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 128060 ]
  }, {
    "id" : 128098,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1350,
      "y" : 1495
    },
    "minX" : 86,
    "maxX" : 2614,
    "minY" : 975,
    "maxY" : 2016,
    "prop" : {
      "x" : 86,
      "y" : 975,
      "width" : 2528,
      "height" : 1041
    },
    "textPosition" : {
      "x" : 1042,
      "y" : 1311
    },
    "insets" : {
      "x" : 96,
      "y" : 985,
      "width" : 2508,
      "height" : 1021
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 128075, 128099, 128066, 128067, 128068, 128069, 128111, 128058 ]
  }, {
    "id" : 128121,
    "reactomeId" : 18730,
    "displayName" : "cilium",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 907,
      "y" : 495
    },
    "minX" : 401,
    "maxX" : 1413,
    "minY" : 0,
    "maxY" : 991,
    "prop" : {
      "x" : 401,
      "y" : 0,
      "width" : 1012,
      "height" : 991
    },
    "textPosition" : {
      "x" : 880,
      "y" : 479
    },
    "insets" : {
      "x" : 411,
      "y" : 10,
      "width" : 992,
      "height" : 971
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 128073 ]
  }, {
    "id" : 128111,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1665,
      "y" : 1476
    },
    "minX" : 1296,
    "maxX" : 2035,
    "minY" : 1069,
    "maxY" : 1883,
    "prop" : {
      "x" : 1296,
      "y" : 1069,
      "width" : 739,
      "height" : 814
    },
    "textPosition" : {
      "x" : 1428,
      "y" : 1116
    },
    "insets" : {
      "x" : 1306,
      "y" : 1079,
      "width" : 719,
      "height" : 794
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 128072, 128086, 128114, 128122, 128085, 128084, 128087, 128123, 128088, 128089, 128090, 128091, 128095, 128093, 128094, 128097, 128096, 128092 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 128123,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 1478,
      "y" : 1381
    },
    "minX" : 1379,
    "maxX" : 1578,
    "minY" : 1279,
    "maxY" : 1483,
    "segments" : [ {
      "from" : {
        "x" : 1379,
        "y" : 1483
      },
      "to" : {
        "x" : 1578,
        "y" : 1279
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1472,
        "y" : 1375
      },
      "b" : {
        "x" : 1484,
        "y" : 1387
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1478,
        "y" : 1381
      }
    },
    "inputs" : [ {
      "id" : 128090
    } ],
    "outputs" : [ {
      "id" : 128086
    } ]
  }, {
    "id" : 128122,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1543,
      "y" : 1391
    },
    "minX" : 1499,
    "maxX" : 1587,
    "minY" : 1279,
    "maxY" : 1503,
    "segments" : [ {
      "from" : {
        "x" : 1499,
        "y" : 1503
      },
      "to" : {
        "x" : 1587,
        "y" : 1279
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1537,
        "y" : 1385
      },
      "b" : {
        "x" : 1549,
        "y" : 1397
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1543,
        "y" : 1391
      }
    },
    "inputs" : [ {
      "id" : 128114
    } ],
    "outputs" : [ {
      "id" : 128086
    } ]
  } ],
  "shadows" : [ {
    "id" : 128125,
    "reactomeId" : 10912820,
    "displayName" : "Activation of SMO",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 652,
      "y" : 612
    },
    "minX" : 530,
    "maxX" : 774,
    "minY" : 272,
    "maxY" : 953,
    "prop" : {
      "x" : 530,
      "y" : 272,
      "width" : 244,
      "height" : 681
    },
    "points" : [ {
      "x" : 530,
      "y" : 272
    }, {
      "x" : 774,
      "y" : 272
    }, {
      "x" : 774,
      "y" : 953
    }, {
      "x" : 530,
      "y" : 953
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 128124,
    "reactomeId" : 10912818,
    "displayName" : "Ligand-receptor interactions",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 236,
      "y" : 572
    },
    "minX" : -10,
    "maxX" : 482,
    "minY" : 483,
    "maxY" : 662,
    "prop" : {
      "x" : -10,
      "y" : 483,
      "width" : 492,
      "height" : 179
    },
    "points" : [ {
      "x" : -10,
      "y" : 483
    }, {
      "x" : 482,
      "y" : 483
    }, {
      "x" : 482,
      "y" : 662
    }, {
      "x" : -10,
      "y" : 662
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 2614,
  "minY" : 0,
  "maxY" : 2016,
  "disease" : false
}