{ "dbId" : 10912492, "stableId" : "R-DME-5627123", "displayName" : "RHO GTPases activate PAKs", "nodes" : [ { "id" : 36608, "reactomeId" : 10877204, "displayName" : "p-S,T-PAK1,2,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 629, "y" : 225 }, "minX" : 575, "maxX" : 683, "minY" : 185, "maxY" : 236, "prop" : { "x" : 575, "y" : 214, "width" : 108, "height" : 22 }, "textPosition" : { "x" : 580, "y" : 214 }, "connectors" : [ { "edgeId" : 36604, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 628, "y" : 208 }, "to" : { "x" : 627, "y" : 185 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 624, "y" : 201 }, "b" : { "x" : 628, "y" : 208 }, "c" : { "x" : 632, "y" : 201 }, "type" : "ARROW", "centre" : { "x" : 632, "y" : 201 } } } ] }, { "id" : 36609, "reactomeId" : 10849363, "displayName" : "CDC42:GTP, RAC1:GTP", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 106, "y" : 146 }, "minX" : 66, "maxX" : 716, "minY" : 0, "maxY" : 185, "prop" : { "x" : 66, "y" : 125, "width" : 81, "height" : 42 }, "textPosition" : { "x" : 64, "y" : 128 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 36632, "type" : "INPUT", "segments" : [ { "from" : { "x" : 153, "y" : 161 }, "to" : { "x" : 210, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 36635, "type" : "INPUT", "segments" : [ { "from" : { "x" : 153, "y" : 152 }, "to" : { "x" : 205, "y" : 161 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 36604, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 105, "y" : 119 }, "to" : { "x" : 103, "y" : 3 } }, { "from" : { "x" : 103, "y" : 3 }, "to" : { "x" : 716, "y" : 0 } }, { "from" : { "x" : 716, "y" : 0 }, "to" : { "x" : 712, "y" : 180 } }, { "from" : { "x" : 712, "y" : 180 }, "to" : { "x" : 627, "y" : 185 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 98, "y" : 55 }, "b" : { "x" : 110, "y" : 67 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 104, "y" : 61 } } }, "endShape" : { "a" : { "x" : 101, "y" : 112 }, "b" : { "x" : 105, "y" : 119 }, "c" : { "x" : 109, "y" : 112 }, "type" : "ARROW", "centre" : { "x" : 109, "y" : 112 } } }, { "edgeId" : 36639, "type" : "INPUT", "segments" : [ { "from" : { "x" : 153, "y" : 142 }, "to" : { "x" : 220, "y" : 137 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 36611, "reactomeId" : 10850111, "displayName" : "LIMK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 539, "y" : 342 }, "minX" : 517, "maxX" : 567, "minY" : 325, "maxY" : 388, "prop" : { "x" : 517, "y" : 331, "width" : 44, "height" : 22 }, "textPosition" : { "x" : 518, "y" : 331 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 561, "y" : 331 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 561, "y" : 331 } } }, "connectors" : [ { "edgeId" : 36610, "type" : "INPUT", "segments" : [ { "from" : { "x" : 538, "y" : 356 }, "to" : { "x" : 538, "y" : 388 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 36612, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 588, "y" : 377 }, "minX" : 538, "maxX" : 611, "minY" : 363, "maxY" : 390, "prop" : { "x" : 567, "y" : 364, "width" : 43, "height" : 26 }, "textPosition" : { "x" : 573, "y" : 366 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 605, "y" : 369 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 605, "y" : 369 } } }, "connectors" : [ { "edgeId" : 36610, "type" : "INPUT", "segments" : [ { "from" : { "x" : 564, "y" : 381 }, "to" : { "x" : 538, "y" : 388 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 36613, "reactomeId" : 10850114, "displayName" : "phospho-p-T508-LIMK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 542, "y" : 506 }, "minX" : 493, "maxX" : 597, "minY" : 451, "maxY" : 517, "prop" : { "x" : 493, "y" : 495, "width" : 98, "height" : 22 }, "textPosition" : { "x" : 502, "y" : 489 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 591, "y" : 495 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 591, "y" : 495 } } }, "connectors" : [ { "edgeId" : 36610, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 541, "y" : 492 }, "to" : { "x" : 540, "y" : 451 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 537, "y" : 485 }, "b" : { "x" : 541, "y" : 492 }, "c" : { "x" : 545, "y" : 485 }, "type" : "ARROW", "centre" : { "x" : 545, "y" : 485 } } } ] }, { "id" : 36614, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 592, "y" : 459 }, "minX" : 540, "maxX" : 615, "minY" : 445, "maxY" : 472, "prop" : { "x" : 570, "y" : 446, "width" : 44, "height" : 26 }, "textPosition" : { "x" : 575, "y" : 448 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 609, "y" : 451 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 609, "y" : 451 } } }, "connectors" : [ { "edgeId" : 36610, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 567, "y" : 455 }, "to" : { "x" : 540, "y" : 451 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 560, "y" : 458 }, "b" : { "x" : 567, "y" : 455 }, "c" : { "x" : 561, "y" : 450 }, "type" : "ARROW", "centre" : { "x" : 561, "y" : 450 } } } ] }, { "id" : 36615, "reactomeId" : 10853681, "displayName" : "Homologues of p-S144,T423-PAK1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 638, "y" : 302 }, "minX" : 547, "maxX" : 867, "minY" : 287, "maxY" : 781, "prop" : { "x" : 573, "y" : 287, "width" : 130, "height" : 30 }, "textPosition" : { "x" : 579, "y" : 285 }, "connectors" : [ { "edgeId" : 36625, "type" : "INPUT", "segments" : [ { "from" : { "x" : 637, "y" : 320 }, "to" : { "x" : 632, "y" : 555 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 36610, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 634, "y" : 320 }, "to" : { "x" : 612, "y" : 409 } }, { "from" : { "x" : 612, "y" : 409 }, "to" : { "x" : 555, "y" : 415 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 551, "y" : 416 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 551, "y" : 416 } } }, { "edgeId" : 36628, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 642, "y" : 320 }, "to" : { "x" : 762, "y" : 699 } }, { "from" : { "x" : 762, "y" : 699 }, "to" : { "x" : 648, "y" : 781 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 648, "y" : 325 }, "b" : { "x" : 642, "y" : 320 }, "c" : { "x" : 640, "y" : 328 }, "type" : "ARROW", "centre" : { "x" : 640, "y" : 328 } } }, { "edgeId" : 36616, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 706, "y" : 302 }, "to" : { "x" : 730, "y" : 303 } }, { "from" : { "x" : 730, "y" : 303 }, "to" : { "x" : 772, "y" : 620 } }, { "from" : { "x" : 772, "y" : 620 }, "to" : { "x" : 860, "y" : 667 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 863, "y" : 669 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 863, "y" : 669 } } } ] }, { "id" : 36617, "reactomeId" : 10880915, "displayName" : "Myosin phosphatase", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 872, "y" : 609 }, "minX" : 825, "maxX" : 925, "minY" : 586, "maxY" : 652, "prop" : { "x" : 825, "y" : 592, "width" : 94, "height" : 35 }, "textPosition" : { "x" : 826, "y" : 592 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 919, "y" : 592 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 919, "y" : 592 } } }, "connectors" : [ { "edgeId" : 36616, "type" : "INPUT", "segments" : [ { "from" : { "x" : 872, "y" : 630 }, "to" : { "x" : 874, "y" : 652 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 36618, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 941, "y" : 652 }, "minX" : 874, "maxX" : 961, "minY" : 636, "maxY" : 667, "prop" : { "x" : 922, "y" : 637, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 925, "y" : 641 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 955, "y" : 642 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 955, "y" : 642 } } }, "connectors" : [ { "edgeId" : 36616, "type" : "INPUT", "segments" : [ { "from" : { "x" : 919, "y" : 652 }, "to" : { "x" : 874, "y" : 652 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 36619, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 937, "y" : 702 }, "minX" : 875, "maxX" : 960, "minY" : 687, "maxY" : 717, "prop" : { "x" : 915, "y" : 688, "width" : 44, "height" : 29 }, "textPosition" : { "x" : 920, "y" : 692 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 954, "y" : 693 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 954, "y" : 693 } } }, "connectors" : [ { "edgeId" : 36616, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 912, "y" : 701 }, "to" : { "x" : 875, "y" : 701 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 905, "y" : 705 }, "b" : { "x" : 912, "y" : 701 }, "c" : { "x" : 905, "y" : 697 }, "type" : "ARROW", "centre" : { "x" : 905, "y" : 697 } } } ] }, { "id" : 36620, "reactomeId" : 10880920, "displayName" : "p-T696-PPP1R12A-Myosin phosphatase", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 876, "y" : 764 }, "minX" : 813, "maxX" : 945, "minY" : 701, "maxY" : 789, "prop" : { "x" : 813, "y" : 739, "width" : 126, "height" : 50 }, "textPosition" : { "x" : 814, "y" : 740 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 939, "y" : 739 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 939, "y" : 739 } } }, "connectors" : [ { "edgeId" : 36616, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 875, "y" : 736 }, "to" : { "x" : 875, "y" : 701 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 871, "y" : 729 }, "b" : { "x" : 875, "y" : 736 }, "c" : { "x" : 879, "y" : 729 }, "type" : "ARROW", "centre" : { "x" : 879, "y" : 729 } } } ] }, { "id" : 36622, "reactomeId" : 10849376, "displayName" : "PAK1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 175, "y" : 280 }, "minX" : 108, "maxX" : 220, "minY" : 185, "maxY" : 291, "prop" : { "x" : 136, "y" : 269, "width" : 78, "height" : 22 }, "textPosition" : { "x" : 136, "y" : 270 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 214, "y" : 269 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 214, "y" : 269 } } }, "connectors" : [ { "edgeId" : 36632, "type" : "INPUT", "segments" : [ { "from" : { "x" : 179, "y" : 266 }, "to" : { "x" : 210, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 36621, "type" : "INPUT", "segments" : [ { "from" : { "x" : 133, "y" : 280 }, "to" : { "x" : 108, "y" : 280 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 36623, "reactomeId" : 10868843, "displayName" : "Mer", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 42, "y" : 252 }, "minX" : 0, "maxX" : 264, "minY" : 200, "maxY" : 388, "prop" : { "x" : 26, "y" : 241, "width" : 32, "height" : 22 }, "textPosition" : { "x" : 26, "y" : 241 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 58, "y" : 241 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 58, "y" : 241 } } }, "connectors" : [ { "edgeId" : 36632, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 23, "y" : 251 }, "to" : { "x" : 1, "y" : 251 } }, { "from" : { "x" : 1, "y" : 251 }, "to" : { "x" : 0, "y" : 388 } }, { "from" : { "x" : 0, "y" : 388 }, "to" : { "x" : 238, "y" : 376 } }, { "from" : { "x" : 238, "y" : 376 }, "to" : { "x" : 260, "y" : 200 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 256, "y" : 200 }, "b" : { "x" : 264, "y" : 200 }, "c" : { "x" : 260, "y" : 200 }, "type" : "STOP", "centre" : { "x" : 260, "y" : 200 } } }, { "edgeId" : 36621, "type" : "INPUT", "segments" : [ { "from" : { "x" : 61, "y" : 258 }, "to" : { "x" : 108, "y" : 280 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 36624, "reactomeId" : 10880926, "displayName" : "PAK1:NF2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 52, "y" : 338 }, "minX" : 18, "maxX" : 92, "minY" : 321, "maxY" : 349, "prop" : { "x" : 18, "y" : 327, "width" : 68, "height" : 22 }, "textPosition" : { "x" : 18, "y" : 328 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 86, "y" : 327 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 86, "y" : 327 } } }, "connectors" : [ { "edgeId" : 36621, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 36626, "reactomeId" : 10880930, "displayName" : "FLNA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 582, "y" : 549 }, "minX" : 563, "maxX" : 632, "minY" : 532, "maxY" : 560, "prop" : { "x" : 563, "y" : 538, "width" : 38, "height" : 22 }, "textPosition" : { "x" : 563, "y" : 539 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 601, "y" : 538 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 601, "y" : 538 } } }, "connectors" : [ { "edgeId" : 36625, "type" : "INPUT", "segments" : [ { "from" : { "x" : 604, "y" : 551 }, "to" : { "x" : 632, "y" : 555 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 36627, "reactomeId" : 10880932, "displayName" : "p-S144,T423-PAK1:FLNA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 642, "y" : 679 }, "minX" : 594, "maxX" : 697, "minY" : 655, "maxY" : 753, "prop" : { "x" : 594, "y" : 661, "width" : 97, "height" : 36 }, "textPosition" : { "x" : 597, "y" : 662 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 691, "y" : 661 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 691, "y" : 661 } } }, "connectors" : [ { "edgeId" : 36625, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 36628, "type" : "INPUT", "segments" : [ { "from" : { "x" : 644, "y" : 700 }, "to" : { "x" : 648, "y" : 731 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 36628, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 654, "y" : 700 }, "to" : { "x" : 681, "y" : 734 } }, { "from" : { "x" : 681, "y" : 734 }, "to" : { "x" : 662, "y" : 747 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 659, "y" : 749 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 659, "y" : 749 } } } ] }, { "id" : 36629, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 566, "y" : 724 }, "minX" : 544, "maxX" : 648, "minY" : 710, "maxY" : 737, "prop" : { "x" : 544, "y" : 711, "width" : 45, "height" : 26 }, "textPosition" : { "x" : 551, "y" : 713 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 584, "y" : 716 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 584, "y" : 716 } } }, "connectors" : [ { "edgeId" : 36628, "type" : "INPUT", "segments" : [ { "from" : { "x" : 592, "y" : 725 }, "to" : { "x" : 648, "y" : 731 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 614, "y" : 722 }, "b" : { "x" : 626, "y" : 734 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 620, "y" : 728 } } } } ] }, { "id" : 36630, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 557, "y" : 770 }, "minX" : 535, "maxX" : 648, "minY" : 758, "maxY" : 782, "prop" : { "x" : 535, "y" : 759, "width" : 44, "height" : 23 }, "textPosition" : { "x" : 540, "y" : 760 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 574, "y" : 764 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 574, "y" : 764 } } }, "connectors" : [ { "edgeId" : 36628, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 582, "y" : 772 }, "to" : { "x" : 648, "y" : 781 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 609, "y" : 770 }, "b" : { "x" : 621, "y" : 782 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 615, "y" : 776 } } }, "endShape" : { "a" : { "x" : 589, "y" : 769 }, "b" : { "x" : 582, "y" : 772 }, "c" : { "x" : 588, "y" : 777 }, "type" : "ARROW", "centre" : { "x" : 588, "y" : 777 } } } ] }, { "id" : 36631, "reactomeId" : 10880939, "displayName" : "p-S2152-FLNA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 649, "y" : 821 }, "minX" : 600, "maxX" : 704, "minY" : 781, "maxY" : 832, "prop" : { "x" : 600, "y" : 810, "width" : 98, "height" : 22 }, "textPosition" : { "x" : 602, "y" : 811 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 698, "y" : 810 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 698, "y" : 810 } } }, "connectors" : [ { "edgeId" : 36628, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 648, "y" : 807 }, "to" : { "x" : 648, "y" : 781 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 644, "y" : 800 }, "b" : { "x" : 648, "y" : 807 }, "c" : { "x" : 652, "y" : 800 }, "type" : "ARROW", "centre" : { "x" : 652, "y" : 800 } } } ] }, { "id" : 36633, "reactomeId" : 10849374, "displayName" : "Homologues of PAK1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 336, "y" : 245 }, "minX" : 308, "maxX" : 356, "minY" : 188, "maxY" : 256, "prop" : { "x" : 316, "y" : 234, "width" : 40, "height" : 22 }, "textPosition" : { "x" : 316, "y" : 207 }, "connectors" : [ { "edgeId" : 36632, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 330, "y" : 231 }, "to" : { "x" : 308, "y" : 188 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 323, "y" : 227 }, "b" : { "x" : 330, "y" : 231 }, "c" : { "x" : 330, "y" : 223 }, "type" : "ARROW", "centre" : { "x" : 330, "y" : 223 } } } ] }, { "id" : 36634, "reactomeId" : 10868836, "displayName" : "RAC1:GTP,CDC42:GTP:PAK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 424, "y" : 126 }, "minX" : 308, "maxX" : 489, "minY" : 102, "maxY" : 188, "prop" : { "x" : 365, "y" : 108, "width" : 118, "height" : 36 }, "textPosition" : { "x" : 365, "y" : 109 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 483, "y" : 108 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 483, "y" : 108 } } }, "connectors" : [ { "edgeId" : 36632, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 362, "y" : 124 }, "to" : { "x" : 341, "y" : 124 } }, { "from" : { "x" : 341, "y" : 124 }, "to" : { "x" : 308, "y" : 188 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 355, "y" : 128 }, "b" : { "x" : 362, "y" : 124 }, "c" : { "x" : 355, "y" : 120 }, "type" : "ARROW", "centre" : { "x" : 355, "y" : 120 } } } ] }, { "id" : 36636, "reactomeId" : 10849384, "displayName" : "PAK2 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 144, "y" : 238 }, "minX" : 106, "maxX" : 205, "minY" : 161, "maxY" : 250, "prop" : { "x" : 106, "y" : 227, "width" : 77, "height" : 23 }, "textPosition" : { "x" : 123, "y" : 215 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 183, "y" : 227 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 183, "y" : 227 } } }, "connectors" : [ { "edgeId" : 36635, "type" : "INPUT", "segments" : [ { "from" : { "x" : 153, "y" : 224 }, "to" : { "x" : 205, "y" : 161 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 36637, "reactomeId" : 10849382, "displayName" : "Homologues of PAK2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 375, "y" : 215 }, "minX" : 303, "maxX" : 396, "minY" : 163, "maxY" : 226, "prop" : { "x" : 354, "y" : 204, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 355, "y" : 177 }, "connectors" : [ { "edgeId" : 36635, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 359, "y" : 201 }, "to" : { "x" : 303, "y" : 163 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 351, "y" : 200 }, "b" : { "x" : 359, "y" : 201 }, "c" : { "x" : 356, "y" : 194 }, "type" : "ARROW", "centre" : { "x" : 356, "y" : 194 } } } ] }, { "id" : 36638, "reactomeId" : 10879678, "displayName" : "CDC42:GTP,RAC1:GTP:PAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 420, "y" : 78 }, "minX" : 303, "maxX" : 485, "minY" : 54, "maxY" : 163, "prop" : { "x" : 361, "y" : 60, "width" : 118, "height" : 36 }, "textPosition" : { "x" : 361, "y" : 61 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 479, "y" : 60 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 479, "y" : 60 } } }, "connectors" : [ { "edgeId" : 36635, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 358, "y" : 85 }, "to" : { "x" : 336, "y" : 89 } }, { "from" : { "x" : 336, "y" : 89 }, "to" : { "x" : 303, "y" : 163 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 352, "y" : 90 }, "b" : { "x" : 358, "y" : 85 }, "c" : { "x" : 350, "y" : 82 }, "type" : "ARROW", "centre" : { "x" : 350, "y" : 82 } } } ] }, { "id" : 36640, "reactomeId" : 10849388, "displayName" : "PAK3 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 116, "y" : 201 }, "minX" : 76, "maxX" : 220, "minY" : 137, "maxY" : 212, "prop" : { "x" : 76, "y" : 190, "width" : 81, "height" : 22 }, "textPosition" : { "x" : 77, "y" : 191 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 157, "y" : 190 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 157, "y" : 190 } } }, "connectors" : [ { "edgeId" : 36639, "type" : "INPUT", "segments" : [ { "from" : { "x" : 133, "y" : 187 }, "to" : { "x" : 220, "y" : 137 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 36641, "reactomeId" : 10879680, "displayName" : "CDC42:GTP,RAC1:GTP:PAK3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 419, "y" : 36 }, "minX" : 291, "maxX" : 484, "minY" : 12, "maxY" : 134, "prop" : { "x" : 360, "y" : 18, "width" : 118, "height" : 36 }, "textPosition" : { "x" : 360, "y" : 19 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 478, "y" : 18 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 478, "y" : 18 } } }, "connectors" : [ { "edgeId" : 36639, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 357, "y" : 46 }, "to" : { "x" : 320, "y" : 53 } }, { "from" : { "x" : 320, "y" : 53 }, "to" : { "x" : 291, "y" : 134 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 351, "y" : 51 }, "b" : { "x" : 357, "y" : 46 }, "c" : { "x" : 349, "y" : 43 }, "type" : "ARROW", "centre" : { "x" : 349, "y" : 43 } } } ] }, { "id" : 36642, "reactomeId" : 10849386, "displayName" : "PAK3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 405, "y" : 181 }, "minX" : 291, "maxX" : 431, "minY" : 134, "maxY" : 192, "prop" : { "x" : 385, "y" : 170, "width" : 40, "height" : 22 }, "textPosition" : { "x" : 385, "y" : 170 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 425, "y" : 170 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 425, "y" : 170 } } }, "connectors" : [ { "edgeId" : 36639, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 382, "y" : 172 }, "to" : { "x" : 291, "y" : 134 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 374, "y" : 173 }, "b" : { "x" : 382, "y" : 172 }, "c" : { "x" : 377, "y" : 166 }, "type" : "ARROW", "centre" : { "x" : 377, "y" : 166 } } } ] }, { "id" : 36644, "reactomeId" : 10911976, "displayName" : "RHO GTPases Activate ROCKs", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 542, "y" : 611 }, "minX" : 481, "maxX" : 604, "minY" : 583, "maxY" : 640, "prop" : { "x" : 481, "y" : 583, "width" : 123, "height" : 57 }, "textPosition" : { "x" : 488, "y" : 590 }, "connectors" : [ ] }, { "id" : 36645, "reactomeId" : 10911578, "displayName" : "Fcgamma receptor (FCGR) dependent phagocytosis", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 344, "y" : 507 }, "minX" : 265, "maxX" : 424, "minY" : 473, "maxY" : 542, "prop" : { "x" : 265, "y" : 473, "width" : 159, "height" : 69 }, "textPosition" : { "x" : 275, "y" : 479 }, "connectors" : [ ] }, { "id" : 36648, "reactomeId" : 10871891, "displayName" : "phospho-p-S141,T402-PAK2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 940, "y" : 272 }, "minX" : 873, "maxX" : 1013, "minY" : 252, "maxY" : 287, "prop" : { "x" : 873, "y" : 258, "width" : 134, "height" : 29 }, "textPosition" : { "x" : 882, "y" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1007, "y" : 258 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1007, "y" : 258 } } }, "connectors" : [ ] }, { "id" : 36605, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 575, "y" : 109 }, "minX" : 555, "maxX" : 634, "minY" : 93, "maxY" : 124, "prop" : { "x" : 555, "y" : 94, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 559, "y" : 98 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 590, "y" : 99 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 590, "y" : 99 } } }, "connectors" : [ { "edgeId" : 36604, "type" : "INPUT", "segments" : [ { "from" : { "x" : 598, "y" : 107 }, "to" : { "x" : 634, "y" : 105 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 610, "y" : 100 }, "b" : { "x" : 622, "y" : 112 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 616, "y" : 106 } } } } ] }, { "id" : 36606, "reactomeId" : 10879682, "displayName" : "CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 629, "y" : 46 }, "minX" : 556, "maxX" : 703, "minY" : 19, "maxY" : 143, "prop" : { "x" : 556, "y" : 19, "width" : 147, "height" : 54 }, "textPosition" : { "x" : 557, "y" : 28 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 36604, "type" : "INPUT", "segments" : [ { "from" : { "x" : 631, "y" : 79 }, "to" : { "x" : 634, "y" : 105 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 36604, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 646, "y" : 79 }, "to" : { "x" : 663, "y" : 99 } }, { "from" : { "x" : 663, "y" : 99 }, "to" : { "x" : 640, "y" : 135 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 638, "y" : 139 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 638, "y" : 139 } } } ] }, { "id" : 36607, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 560, "y" : 154 }, "minX" : 540, "maxX" : 627, "minY" : 138, "maxY" : 185, "prop" : { "x" : 540, "y" : 139, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 543, "y" : 143 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 575, "y" : 144 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 575, "y" : 144 } } }, "connectors" : [ { "edgeId" : 36604, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 583, "y" : 163 }, "to" : { "x" : 627, "y" : 185 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 599, "y" : 168 }, "b" : { "x" : 611, "y" : 180 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 605, "y" : 174 } } }, "endShape" : { "a" : { "x" : 591, "y" : 163 }, "b" : { "x" : 583, "y" : 163 }, "c" : { "x" : 587, "y" : 170 }, "type" : "ARROW", "centre" : { "x" : 587, "y" : 170 } } } ] } ], "edges" : [ { "id" : 36625, "reactomeId" : 10880934, "displayName" : "FLNA binds PAK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 635, "y" : 584 }, "minX" : 629, "maxX" : 641, "minY" : 555, "maxY" : 658, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 632, "y" : 555 }, "to" : { "x" : 635, "y" : 584 } }, { "from" : { "x" : 635, "y" : 584 }, "to" : { "x" : 640, "y" : 658 } } ], "endShape" : { "a" : { "x" : 636, "y" : 651 }, "b" : { "x" : 640, "y" : 658 }, "c" : { "x" : 644, "y" : 651 }, "type" : "ARROW", "centre" : { "x" : 644, "y" : 651 } }, "reactionShape" : { "c" : { "x" : 635, "y" : 584 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 635, "y" : 584 } }, "inputs" : [ { "id" : 36615, "points" : [ { "x" : 637, "y" : 320 } ] }, { "id" : 36626, "points" : [ { "x" : 604, "y" : 551 } ] } ], "outputs" : [ { "id" : 36627 } ] }, { "id" : 36610, "reactomeId" : 10868849, "displayName" : "PAK1 phosphorylates LIMK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 539, "y" : 417 }, "minX" : 533, "maxX" : 545, "minY" : 388, "maxY" : 451, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 538, "y" : 388 }, "to" : { "x" : 539, "y" : 417 } }, { "from" : { "x" : 539, "y" : 417 }, "to" : { "x" : 540, "y" : 451 } } ], "reactionShape" : { "a" : { "x" : 533, "y" : 411 }, "b" : { "x" : 545, "y" : 423 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 539, "y" : 417 } }, "inputs" : [ { "id" : 36611, "points" : [ { "x" : 538, "y" : 356 } ] }, { "id" : 36612, "points" : [ { "x" : 564, "y" : 381 } ] } ], "outputs" : [ { "id" : 36613, "points" : [ { "x" : 541, "y" : 492 } ] }, { "id" : 36614, "points" : [ { "x" : 567, "y" : 455 } ] } ], "catalysts" : [ { "id" : 36615, "points" : [ { "x" : 634, "y" : 320 }, { "x" : 612, "y" : 409 } ] } ] }, { "id" : 36628, "reactomeId" : 10880942, "displayName" : "PAK1 phosphorylates FLNA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 649, "y" : 756 }, "minX" : 643, "maxX" : 655, "minY" : 731, "maxY" : 781, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 648, "y" : 731 }, "to" : { "x" : 649, "y" : 756 } }, { "from" : { "x" : 649, "y" : 756 }, "to" : { "x" : 648, "y" : 781 } } ], "reactionShape" : { "a" : { "x" : 643, "y" : 750 }, "b" : { "x" : 655, "y" : 762 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 649, "y" : 756 } }, "inputs" : [ { "id" : 36629, "points" : [ { "x" : 592, "y" : 725 } ], "stoichiometry" : 2 }, { "id" : 36627, "points" : [ { "x" : 644, "y" : 700 } ] } ], "outputs" : [ { "id" : 36615, "points" : [ { "x" : 642, "y" : 320 }, { "x" : 762, "y" : 699 } ] }, { "id" : 36630, "points" : [ { "x" : 582, "y" : 772 } ], "stoichiometry" : 2 }, { "id" : 36631, "points" : [ { "x" : 648, "y" : 807 } ] } ], "catalysts" : [ { "id" : 36627, "points" : [ { "x" : 654, "y" : 700 }, { "x" : 681, "y" : 734 } ] } ] }, { "id" : 36632, "reactomeId" : 10868845, "displayName" : "RAC1 and CDC42 activate PAK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 261, "y" : 191 }, "minX" : 210, "maxX" : 308, "minY" : 185, "maxY" : 197, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 210, "y" : 185 }, "to" : { "x" : 261, "y" : 191 } }, { "from" : { "x" : 261, "y" : 191 }, "to" : { "x" : 308, "y" : 188 } } ], "reactionShape" : { "a" : { "x" : 255, "y" : 185 }, "b" : { "x" : 267, "y" : 197 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 261, "y" : 191 } }, "inputs" : [ { "id" : 36609, "points" : [ { "x" : 153, "y" : 161 } ] }, { "id" : 36622, "points" : [ { "x" : 179, "y" : 266 } ] } ], "outputs" : [ { "id" : 36633, "points" : [ { "x" : 330, "y" : 231 } ] }, { "id" : 36634, "points" : [ { "x" : 362, "y" : 124 }, { "x" : 341, "y" : 124 } ] } ], "inhibitors" : [ { "id" : 36623, "points" : [ { "x" : 23, "y" : 251 }, { "x" : 1, "y" : 251 }, { "x" : 0, "y" : 388 }, { "x" : 238, "y" : 376 } ] } ] }, { "id" : 36616, "reactomeId" : 10880922, "displayName" : "PAK1 phosphorylates myosin phosphatase", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 874, "y" : 675 }, "minX" : 868, "maxX" : 880, "minY" : 652, "maxY" : 701, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 874, "y" : 652 }, "to" : { "x" : 874, "y" : 675 } }, { "from" : { "x" : 874, "y" : 675 }, "to" : { "x" : 875, "y" : 701 } } ], "reactionShape" : { "a" : { "x" : 868, "y" : 669 }, "b" : { "x" : 880, "y" : 681 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 874, "y" : 675 } }, "inputs" : [ { "id" : 36617, "points" : [ { "x" : 872, "y" : 630 } ] }, { "id" : 36618, "points" : [ { "x" : 919, "y" : 652 } ] } ], "outputs" : [ { "id" : 36619, "points" : [ { "x" : 912, "y" : 701 } ] }, { "id" : 36620, "points" : [ { "x" : 875, "y" : 736 } ] } ], "catalysts" : [ { "id" : 36615, "points" : [ { "x" : 706, "y" : 302 }, { "x" : 730, "y" : 303 }, { "x" : 772, "y" : 620 } ] } ] }, { "id" : 36635, "reactomeId" : 10900927, "displayName" : "RAC1 and CDC42 activate PAK2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 264, "y" : 160 }, "minX" : 205, "maxX" : 303, "minY" : 154, "maxY" : 166, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 205, "y" : 161 }, "to" : { "x" : 264, "y" : 160 } }, { "from" : { "x" : 264, "y" : 160 }, "to" : { "x" : 303, "y" : 163 } } ], "reactionShape" : { "a" : { "x" : 258, "y" : 154 }, "b" : { "x" : 270, "y" : 166 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 264, "y" : 160 } }, "inputs" : [ { "id" : 36609, "points" : [ { "x" : 153, "y" : 152 } ] }, { "id" : 36636, "points" : [ { "x" : 153, "y" : 224 } ] } ], "outputs" : [ { "id" : 36637, "points" : [ { "x" : 359, "y" : 201 } ] }, { "id" : 36638, "points" : [ { "x" : 358, "y" : 85 }, { "x" : 336, "y" : 89 } ] } ] }, { "id" : 36604, "reactomeId" : 10879685, "displayName" : "Autophosphorylation of PAK1,2,3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 632, "y" : 149 }, "minX" : 626, "maxX" : 638, "minY" : 105, "maxY" : 185, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 634, "y" : 105 }, "to" : { "x" : 632, "y" : 149 } }, { "from" : { "x" : 632, "y" : 149 }, "to" : { "x" : 627, "y" : 185 } } ], "reactionShape" : { "a" : { "x" : 626, "y" : 143 }, "b" : { "x" : 638, "y" : 155 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 632, "y" : 149 } }, "inputs" : [ { "id" : 36605, "points" : [ { "x" : 598, "y" : 107 } ], "stoichiometry" : 2 }, { "id" : 36606, "points" : [ { "x" : 631, "y" : 79 } ] } ], "outputs" : [ { "id" : 36607, "points" : [ { "x" : 583, "y" : 163 } ], "stoichiometry" : 2 }, { "id" : 36608, "points" : [ { "x" : 628, "y" : 208 } ] }, { "id" : 36609, "points" : [ { "x" : 105, "y" : 119 }, { "x" : 103, "y" : 3 }, { "x" : 716, "y" : 0 }, { "x" : 712, "y" : 180 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 36606, "points" : [ { "x" : 646, "y" : 79 }, { "x" : 663, "y" : 99 } ] } ] }, { "id" : 36621, "reactomeId" : 10880928, "displayName" : "NF2 binds PAK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 93, "y" : 297 }, "minX" : 63, "maxX" : 108, "minY" : 280, "maxY" : 324, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 108, "y" : 280 }, "to" : { "x" : 93, "y" : 297 } }, { "from" : { "x" : 93, "y" : 297 }, "to" : { "x" : 63, "y" : 324 } } ], "endShape" : { "a" : { "x" : 65, "y" : 316 }, "b" : { "x" : 63, "y" : 324 }, "c" : { "x" : 71, "y" : 322 }, "type" : "ARROW", "centre" : { "x" : 71, "y" : 322 } }, "reactionShape" : { "c" : { "x" : 93, "y" : 297 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 93, "y" : 297 } }, "inputs" : [ { "id" : 36622, "points" : [ { "x" : 133, "y" : 280 } ] }, { "id" : 36623, "points" : [ { "x" : 61, "y" : 258 } ] } ], "outputs" : [ { "id" : 36624 } ] }, { "id" : 36639, "reactomeId" : 10900925, "displayName" : "RAC1 and CDC42 activate PAK3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 263, "y" : 137 }, "minX" : 220, "maxX" : 291, "minY" : 131, "maxY" : 143, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 220, "y" : 137 }, "to" : { "x" : 263, "y" : 137 } }, { "from" : { "x" : 263, "y" : 137 }, "to" : { "x" : 291, "y" : 134 } } ], "reactionShape" : { "a" : { "x" : 257, "y" : 131 }, "b" : { "x" : 269, "y" : 143 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 263, "y" : 137 } }, "inputs" : [ { "id" : 36609, "points" : [ { "x" : 153, "y" : 142 } ] }, { "id" : 36640, "points" : [ { "x" : 133, "y" : 187 } ] } ], "outputs" : [ { "id" : 36641, "points" : [ { "x" : 357, "y" : 46 }, { "x" : 320, "y" : 53 } ] }, { "id" : 36642, "points" : [ { "x" : 382, "y" : 172 } ] } ] } ], "compartments" : [ { "id" : 36643, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 704, "y" : 451 }, "minX" : 33, "maxX" : 1376, "minY" : 32, "maxY" : 870, "prop" : { "x" : 33, "y" : 32, "width" : 1343, "height" : 838 }, "textPosition" : { "x" : 54, "y" : 620 }, "insets" : { "x" : 43, "y" : 42, "width" : 1323, "height" : 818 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 36609, 36604, 36608, 36610, 36611, 36612, 36658, 36613, 36614, 36615, 36644, 36659, 36645, 36660, 36661, 36648, 36617, 36616, 36618, 36619, 36620, 36662, 36663, 36664, 36621, 36622, 36623, 36624, 36625, 36627, 36626, 36628, 36629, 36631, 36630, 36632, 36633, 36634, 36635, 36636, 36637, 36638, 36639, 36640, 36641, 36642, 36606, 36665, 36666, 36667, 36605, 36607 ] } ], "notes" : [ ], "links" : [ { "id" : 36658, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 633, "y" : 263 }, "minX" : 627, "maxX" : 639, "minY" : 242, "maxY" : 284, "segments" : [ { "from" : { "x" : 636, "y" : 284 }, "to" : { "x" : 630, "y" : 242 } } ], "reactionShape" : { "a" : { "x" : 627, "y" : 257 }, "b" : { "x" : 639, "y" : 269 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 633, "y" : 263 } }, "inputs" : [ { "id" : 36615 } ], "outputs" : [ { "id" : 36608 } ] }, { "id" : 36659, "renderableClass" : "Interaction", "position" : { "x" : 541, "y" : 550 }, "minX" : 535, "maxX" : 547, "minY" : 520, "maxY" : 580, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 541, "y" : 580 }, "to" : { "x" : 541, "y" : 520 } } ], "endShape" : { "a" : { "x" : 545, "y" : 527 }, "b" : { "x" : 541, "y" : 520 }, "c" : { "x" : 537, "y" : 527 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 537, "y" : 527 } }, "reactionShape" : { "a" : { "x" : 535, "y" : 544 }, "b" : { "x" : 547, "y" : 556 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 541, "y" : 550 } }, "inputs" : [ { "id" : 36644 } ], "outputs" : [ { "id" : 36613 } ] }, { "id" : 36660, "renderableClass" : "Interaction", "position" : { "x" : 458, "y" : 506 }, "minX" : 427, "maxX" : 490, "minY" : 500, "maxY" : 512, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 490, "y" : 506 }, "to" : { "x" : 427, "y" : 506 } } ], "endShape" : { "a" : { "x" : 434, "y" : 502 }, "b" : { "x" : 427, "y" : 506 }, "c" : { "x" : 434, "y" : 510 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 434, "y" : 510 } }, "reactionShape" : { "a" : { "x" : 452, "y" : 500 }, "b" : { "x" : 464, "y" : 512 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 458, "y" : 506 } }, "inputs" : [ { "id" : 36613 } ], "outputs" : [ { "id" : 36645 } ] }, { "id" : 36661, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 779, "y" : 247 }, "minX" : 689, "maxX" : 870, "minY" : 233, "maxY" : 261, "segments" : [ { "from" : { "x" : 870, "y" : 261 }, "to" : { "x" : 689, "y" : 233 } } ], "reactionShape" : { "a" : { "x" : 773, "y" : 241 }, "b" : { "x" : 785, "y" : 253 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 779, "y" : 247 } }, "inputs" : [ { "id" : 36648 } ], "outputs" : [ { "id" : 36608 } ] }, { "id" : 36665, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 508, "y" : 88 }, "minX" : 466, "maxX" : 550, "minY" : 72, "maxY" : 105, "segments" : [ { "from" : { "x" : 466, "y" : 105 }, "to" : { "x" : 550, "y" : 72 } } ], "reactionShape" : { "a" : { "x" : 502, "y" : 82 }, "b" : { "x" : 514, "y" : 94 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 508, "y" : 88 } }, "inputs" : [ { "id" : 36634 } ], "outputs" : [ { "id" : 36606 } ] }, { "id" : 36666, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 516, "y" : 62 }, "minX" : 482, "maxX" : 550, "minY" : 56, "maxY" : 68, "segments" : [ { "from" : { "x" : 482, "y" : 68 }, "to" : { "x" : 550, "y" : 57 } } ], "reactionShape" : { "a" : { "x" : 510, "y" : 56 }, "b" : { "x" : 522, "y" : 68 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 516, "y" : 62 } }, "inputs" : [ { "id" : 36638 } ], "outputs" : [ { "id" : 36606 } ] }, { "id" : 36667, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 515, "y" : 40 }, "minX" : 481, "maxX" : 550, "minY" : 34, "maxY" : 46, "segments" : [ { "from" : { "x" : 481, "y" : 38 }, "to" : { "x" : 550, "y" : 42 } } ], "reactionShape" : { "a" : { "x" : 509, "y" : 34 }, "b" : { "x" : 521, "y" : 46 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 515, "y" : 40 } }, "inputs" : [ { "id" : 36641 } ], "outputs" : [ { "id" : 36606 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 1376, "minY" : 0, "maxY" : 870, "disease" : false }