{
  "dbId" : 10912292,
  "stableId" : "R-DME-1237044",
  "displayName" : "Erythrocytes take up carbon dioxide and release oxygen",
  "nodes" : [ {
    "id" : 30951,
    "reactomeId" : 1237009,
    "displayName" : "CO2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 148,
      "y" : 16
    },
    "minX" : 128,
    "maxX" : 169,
    "minY" : 0,
    "maxY" : 31,
    "prop" : {
      "x" : 128,
      "y" : 1,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 131,
      "y" : 5
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 163,
          "y" : 6
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 163,
          "y" : 6
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 30950,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 30954,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 30952,
    "reactomeId" : 113528,
    "displayName" : "CO2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 147,
      "y" : 340
    },
    "minX" : 127,
    "maxX" : 325,
    "minY" : 324,
    "maxY" : 355,
    "prop" : {
      "x" : 127,
      "y" : 325,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 130,
      "y" : 329
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 162,
          "y" : 330
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 162,
          "y" : 330
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 30962,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 170,
          "y" : 339
        },
        "to" : {
          "x" : 325,
          "y" : 339
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 30950,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 30954,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 30953,
    "reactomeId" : 10852455,
    "displayName" : "AQP1 tetramer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 239,
      "y" : 135
    },
    "minX" : 174,
    "maxX" : 275,
    "minY" : 111,
    "maxY" : 154,
    "prop" : {
      "x" : 209,
      "y" : 117,
      "width" : 60,
      "height" : 37
    },
    "textPosition" : {
      "x" : 210,
      "y" : 105
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 269,
          "y" : 117
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 269,
          "y" : 117
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 30950,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 206,
          "y" : 135
        },
        "to" : {
          "x" : 182,
          "y" : 136
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 178,
          "y" : 136
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 178,
          "y" : 136
        }
      }
    } ]
  }, {
    "id" : 30955,
    "reactomeId" : 10853466,
    "displayName" : "Rh50",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 62,
      "y" : 137
    },
    "minX" : 36,
    "maxX" : 117,
    "minY" : 120,
    "maxY" : 148,
    "prop" : {
      "x" : 36,
      "y" : 126,
      "width" : 52,
      "height" : 22
    },
    "textPosition" : {
      "x" : 42,
      "y" : 126
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 88,
          "y" : 126
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 88,
          "y" : 126
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 30954,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 91,
          "y" : 137
        },
        "to" : {
          "x" : 109,
          "y" : 137
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 113,
          "y" : 137
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 113,
          "y" : 137
        }
      }
    } ]
  }, {
    "id" : 30957,
    "reactomeId" : 188972,
    "displayName" : "Cl-",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 693,
      "y" : 39
    },
    "minX" : 633,
    "maxX" : 712,
    "minY" : 23,
    "maxY" : 166,
    "prop" : {
      "x" : 676,
      "y" : 24,
      "width" : 35,
      "height" : 30
    },
    "textPosition" : {
      "x" : 682,
      "y" : 28
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 706,
          "y" : 29
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 706,
          "y" : 29
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 30956,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 693,
          "y" : 57
        },
        "to" : {
          "x" : 693,
          "y" : 111
        }
      }, {
        "from" : {
          "x" : 693,
          "y" : 111
        },
        "to" : {
          "x" : 633,
          "y" : 166
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 30958,
    "reactomeId" : 111627,
    "displayName" : "HCO3-",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 609,
      "y" : 339
    },
    "minX" : 480,
    "maxX" : 638,
    "minY" : 166,
    "maxY" : 354,
    "prop" : {
      "x" : 582,
      "y" : 324,
      "width" : 55,
      "height" : 30
    },
    "textPosition" : {
      "x" : 586,
      "y" : 328
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 632,
          "y" : 329
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 632,
          "y" : 329
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 30962,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 579,
          "y" : 339
        },
        "to" : {
          "x" : 480,
          "y" : 339
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 572,
          "y" : 343
        },
        "b" : {
          "x" : 579,
          "y" : 339
        },
        "c" : {
          "x" : 572,
          "y" : 335
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 572,
          "y" : 335
        }
      }
    }, {
      "edgeId" : 30956,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 611,
          "y" : 321
        },
        "to" : {
          "x" : 633,
          "y" : 166
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 30959,
    "reactomeId" : 352022,
    "displayName" : "Cl-",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 684,
      "y" : 228
    },
    "minX" : 632,
    "maxX" : 703,
    "minY" : 166,
    "maxY" : 243,
    "prop" : {
      "x" : 667,
      "y" : 213,
      "width" : 35,
      "height" : 30
    },
    "textPosition" : {
      "x" : 673,
      "y" : 217
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 697,
          "y" : 218
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 697,
          "y" : 218
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 30956,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 671,
          "y" : 210
        },
        "to" : {
          "x" : 632,
          "y" : 166
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 663,
          "y" : 207
        },
        "b" : {
          "x" : 671,
          "y" : 210
        },
        "c" : {
          "x" : 669,
          "y" : 202
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 669,
          "y" : 202
        }
      }
    } ]
  }, {
    "id" : 30960,
    "reactomeId" : 425425,
    "displayName" : "HCO3-",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 562,
      "y" : 33
    },
    "minX" : 535,
    "maxX" : 632,
    "minY" : 17,
    "maxY" : 166,
    "prop" : {
      "x" : 535,
      "y" : 18,
      "width" : 55,
      "height" : 30
    },
    "textPosition" : {
      "x" : 539,
      "y" : 22
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 585,
          "y" : 23
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 585,
          "y" : 23
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 30956,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 561,
          "y" : 51
        },
        "to" : {
          "x" : 561,
          "y" : 118
        }
      }, {
        "from" : {
          "x" : 561,
          "y" : 118
        },
        "to" : {
          "x" : 632,
          "y" : 166
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 565,
          "y" : 58
        },
        "b" : {
          "x" : 561,
          "y" : 51
        },
        "c" : {
          "x" : 557,
          "y" : 58
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 557,
          "y" : 58
        }
      }
    } ]
  }, {
    "id" : 30961,
    "reactomeId" : 10861106,
    "displayName" : "SLC4A1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 632,
      "y" : 115
    },
    "minX" : 604,
    "maxX" : 666,
    "minY" : 93,
    "maxY" : 157,
    "prop" : {
      "x" : 604,
      "y" : 99,
      "width" : 56,
      "height" : 33
    },
    "textPosition" : {
      "x" : 603,
      "y" : 97
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 660,
          "y" : 99
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 660,
          "y" : 99
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 30956,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 632,
          "y" : 135
        },
        "to" : {
          "x" : 632,
          "y" : 149
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 632,
          "y" : 153
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 632,
          "y" : 153
        }
      }
    } ]
  }, {
    "id" : 30963,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 251,
      "y" : 307
    },
    "minX" : 231,
    "maxX" : 325,
    "minY" : 291,
    "maxY" : 339,
    "prop" : {
      "x" : 231,
      "y" : 292,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 234,
      "y" : 296
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 266,
          "y" : 297
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 266,
          "y" : 297
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 30962,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 274,
          "y" : 315
        },
        "to" : {
          "x" : 325,
          "y" : 339
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 30964,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 456,
      "y" : 400
    },
    "minX" : 439,
    "maxX" : 480,
    "minY" : 339,
    "maxY" : 415,
    "prop" : {
      "x" : 439,
      "y" : 385,
      "width" : 35,
      "height" : 30
    },
    "textPosition" : {
      "x" : 443,
      "y" : 389
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 469,
          "y" : 390
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 469,
          "y" : 390
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 30962,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 461,
          "y" : 382
        },
        "to" : {
          "x" : 480,
          "y" : 339
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 460,
          "y" : 374
        },
        "b" : {
          "x" : 461,
          "y" : 382
        },
        "c" : {
          "x" : 467,
          "y" : 377
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 467,
          "y" : 377
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 30965,
    "reactomeId" : 10862412,
    "displayName" : "CA2:Zn2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 413,
      "y" : 277
    },
    "minX" : 377,
    "maxX" : 456,
    "minY" : 222,
    "maxY" : 331,
    "prop" : {
      "x" : 377,
      "y" : 260,
      "width" : 73,
      "height" : 34
    },
    "textPosition" : {
      "x" : 378,
      "y" : 266
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 450,
          "y" : 260
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 450,
          "y" : 260
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 30962,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 413,
          "y" : 300
        },
        "to" : {
          "x" : 413,
          "y" : 323
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 413,
          "y" : 327
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 413,
          "y" : 327
        }
      }
    }, {
      "edgeId" : 30966,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 412,
          "y" : 254
        },
        "to" : {
          "x" : 411,
          "y" : 222
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 30967,
    "reactomeId" : 9707420,
    "displayName" : "CA inhibitors",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 325,
      "y" : 222
    },
    "minX" : 283,
    "maxX" : 411,
    "minY" : 211,
    "maxY" : 233,
    "prop" : {
      "x" : 283,
      "y" : 211,
      "width" : 84,
      "height" : 22
    },
    "textPosition" : {
      "x" : 292,
      "y" : 205
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 30966,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 373,
          "y" : 222
        },
        "to" : {
          "x" : 411,
          "y" : 222
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 30968,
    "reactomeId" : 10904633,
    "displayName" : "CA1:Zn2+,CA2:Zn2+:CA inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 524,
      "y" : 275
    },
    "minX" : 463,
    "maxX" : 592,
    "minY" : 251,
    "maxY" : 293,
    "prop" : {
      "x" : 463,
      "y" : 257,
      "width" : 123,
      "height" : 36
    },
    "textPosition" : {
      "x" : 473,
      "y" : 244
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 586,
          "y" : 257
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 586,
          "y" : 257
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 30966,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 30962,
    "reactomeId" : 10862489,
    "displayName" : "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 413,
      "y" : 339
    },
    "minX" : 325,
    "maxX" : 480,
    "minY" : 333,
    "maxY" : 345,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 325,
        "y" : 339
      },
      "to" : {
        "x" : 413,
        "y" : 339
      }
    }, {
      "from" : {
        "x" : 413,
        "y" : 339
      },
      "to" : {
        "x" : 480,
        "y" : 339
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 407,
        "y" : 333
      },
      "b" : {
        "x" : 419,
        "y" : 345
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 413,
        "y" : 339
      }
    },
    "inputs" : [ {
      "id" : 30952,
      "points" : [ {
        "x" : 170,
        "y" : 339
      } ]
    }, {
      "id" : 30963,
      "points" : [ {
        "x" : 274,
        "y" : 315
      } ]
    } ],
    "outputs" : [ {
      "id" : 30958,
      "points" : [ {
        "x" : 579,
        "y" : 339
      } ]
    }, {
      "id" : 30964,
      "points" : [ {
        "x" : 461,
        "y" : 382
      } ]
    } ],
    "catalysts" : [ {
      "id" : 30965,
      "points" : [ {
        "x" : 413,
        "y" : 300
      } ]
    } ]
  }, {
    "id" : 30950,
    "reactomeId" : 10861112,
    "displayName" : "AQP1 tetramer transports CO2 from extracellular region to cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 166,
      "y" : 136
    },
    "minX" : 148,
    "maxX" : 172,
    "minY" : 34,
    "maxY" : 322,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 150,
        "y" : 34
      },
      "to" : {
        "x" : 166,
        "y" : 136
      }
    }, {
      "from" : {
        "x" : 166,
        "y" : 136
      },
      "to" : {
        "x" : 148,
        "y" : 322
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 145,
        "y" : 315
      },
      "b" : {
        "x" : 148,
        "y" : 322
      },
      "c" : {
        "x" : 153,
        "y" : 315
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 153,
        "y" : 315
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 160,
        "y" : 130
      },
      "b" : {
        "x" : 172,
        "y" : 142
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 166,
        "y" : 136
      }
    },
    "inputs" : [ {
      "id" : 30951
    } ],
    "outputs" : [ {
      "id" : 30952
    } ],
    "catalysts" : [ {
      "id" : 30953,
      "points" : [ {
        "x" : 206,
        "y" : 135
      } ]
    } ]
  }, {
    "id" : 30966,
    "reactomeId" : 10904635,
    "displayName" : "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 412,
      "y" : 223
    },
    "minX" : 406,
    "maxX" : 485,
    "minY" : 217,
    "maxY" : 254,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 411,
        "y" : 222
      },
      "to" : {
        "x" : 412,
        "y" : 223
      }
    }, {
      "from" : {
        "x" : 412,
        "y" : 223
      },
      "to" : {
        "x" : 485,
        "y" : 254
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 477,
        "y" : 255
      },
      "b" : {
        "x" : 485,
        "y" : 254
      },
      "c" : {
        "x" : 480,
        "y" : 248
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 480,
        "y" : 248
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 412,
        "y" : 223
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 412,
        "y" : 223
      }
    },
    "inputs" : [ {
      "id" : 30967,
      "points" : [ {
        "x" : 373,
        "y" : 222
      } ]
    }, {
      "id" : 30965,
      "points" : [ {
        "x" : 412,
        "y" : 254
      } ]
    } ],
    "outputs" : [ {
      "id" : 30968
    } ]
  }, {
    "id" : 30954,
    "reactomeId" : 10861115,
    "displayName" : "RHAG transports CO2 from extracellular region to cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 125,
      "y" : 137
    },
    "minX" : 119,
    "maxX" : 145,
    "minY" : 34,
    "maxY" : 322,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 145,
        "y" : 34
      },
      "to" : {
        "x" : 125,
        "y" : 137
      }
    }, {
      "from" : {
        "x" : 125,
        "y" : 137
      },
      "to" : {
        "x" : 145,
        "y" : 322
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 140,
        "y" : 316
      },
      "b" : {
        "x" : 145,
        "y" : 322
      },
      "c" : {
        "x" : 148,
        "y" : 315
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 148,
        "y" : 315
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 119,
        "y" : 131
      },
      "b" : {
        "x" : 131,
        "y" : 143
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 125,
        "y" : 137
      }
    },
    "inputs" : [ {
      "id" : 30951
    } ],
    "outputs" : [ {
      "id" : 30952
    } ],
    "catalysts" : [ {
      "id" : 30955,
      "points" : [ {
        "x" : 91,
        "y" : 137
      } ]
    } ]
  }, {
    "id" : 30956,
    "reactomeId" : 10861109,
    "displayName" : "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 632,
      "y" : 165
    },
    "minX" : 626,
    "maxX" : 638,
    "minY" : 159,
    "maxY" : 171,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 633,
        "y" : 166
      },
      "to" : {
        "x" : 632,
        "y" : 165
      }
    }, {
      "from" : {
        "x" : 632,
        "y" : 165
      },
      "to" : {
        "x" : 632,
        "y" : 166
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 626,
        "y" : 159
      },
      "b" : {
        "x" : 638,
        "y" : 171
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 632,
        "y" : 165
      }
    },
    "inputs" : [ {
      "id" : 30957,
      "points" : [ {
        "x" : 693,
        "y" : 57
      }, {
        "x" : 693,
        "y" : 111
      } ]
    }, {
      "id" : 30958,
      "points" : [ {
        "x" : 611,
        "y" : 321
      } ]
    } ],
    "outputs" : [ {
      "id" : 30959,
      "points" : [ {
        "x" : 671,
        "y" : 210
      } ]
    }, {
      "id" : 30960,
      "points" : [ {
        "x" : 561,
        "y" : 51
      }, {
        "x" : 561,
        "y" : 118
      } ]
    } ],
    "catalysts" : [ {
      "id" : 30961,
      "points" : [ {
        "x" : 632,
        "y" : 135
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 30976,
    "reactomeId" : 17957,
    "displayName" : "endoplasmic reticulum lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 167,
      "y" : 493
    },
    "minX" : 103,
    "maxX" : 231,
    "minY" : 457,
    "maxY" : 530,
    "prop" : {
      "x" : 103,
      "y" : 457,
      "width" : 128,
      "height" : 73
    },
    "textPosition" : {
      "x" : 108,
      "y" : 469
    },
    "insets" : {
      "x" : 113,
      "y" : 467,
      "width" : 108,
      "height" : 53
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 30969,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 439,
      "y" : 380
    },
    "minX" : 0,
    "maxX" : 878,
    "minY" : 90,
    "maxY" : 670,
    "prop" : {
      "x" : 0,
      "y" : 90,
      "width" : 878,
      "height" : 580
    },
    "textPosition" : {
      "x" : 38,
      "y" : 224
    },
    "insets" : {
      "x" : 10,
      "y" : 100,
      "width" : 858,
      "height" : 560
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 30952, 30953, 30955, 30954, 30963, 30964, 30958, 30956, 30950, 30961, 30959, 30962, 30965, 30966, 30967, 30968, 30976 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 878,
  "minY" : 0,
  "maxY" : 670,
  "disease" : false
}