{
  "dbId" : 10912090,
  "stableId" : "R-DME-445355",
  "displayName" : "Smooth Muscle Contraction",
  "nodes" : [ {
    "id" : 33571,
    "reactomeId" : 10853877,
    "displayName" : "Inactive Myosin Actin Contractile Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1090,
      "y" : 489
    },
    "minX" : 1035,
    "maxX" : 1195,
    "minY" : 458,
    "maxY" : 533,
    "prop" : {
      "x" : 1035,
      "y" : 464,
      "width" : 110,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1037,
      "y" : 451
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1145,
          "y" : 464
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1145,
          "y" : 464
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33570,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1148,
          "y" : 512
        },
        "to" : {
          "x" : 1195,
          "y" : 533
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33572,
    "reactomeId" : 74016,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1196,
      "y" : 468
    },
    "minX" : 1172,
    "maxX" : 1222,
    "minY" : 452,
    "maxY" : 533,
    "prop" : {
      "x" : 1172,
      "y" : 453,
      "width" : 49,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1175,
      "y" : 457
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1216,
          "y" : 458
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1216,
          "y" : 458
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33570,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1195,
          "y" : 486
        },
        "to" : {
          "x" : 1195,
          "y" : 533
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33573,
    "reactomeId" : 10853881,
    "displayName" : "Calcium Bound Myosin Actin Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1205,
      "y" : 624
    },
    "minX" : 1155,
    "maxX" : 1261,
    "minY" : 593,
    "maxY" : 689,
    "prop" : {
      "x" : 1155,
      "y" : 599,
      "width" : 100,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1153,
      "y" : 600
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1255,
          "y" : 599
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1255,
          "y" : 599
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33570,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33574,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1225,
          "y" : 652
        },
        "to" : {
          "x" : 1258,
          "y" : 689
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1233,
          "y" : 655
        },
        "b" : {
          "x" : 1225,
          "y" : 652
        },
        "c" : {
          "x" : 1227,
          "y" : 660
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1227,
          "y" : 660
        }
      }
    } ]
  }, {
    "id" : 33575,
    "reactomeId" : 10853866,
    "displayName" : "ADP:Calcium Bound Myosin Actin Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1269,
      "y" : 775
    },
    "minX" : 1205,
    "maxX" : 1339,
    "minY" : 744,
    "maxY" : 896,
    "prop" : {
      "x" : 1205,
      "y" : 750,
      "width" : 128,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1220,
      "y" : 751
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1333,
          "y" : 750
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1333,
          "y" : 750
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33574,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33581,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1269,
          "y" : 803
        },
        "to" : {
          "x" : 1269,
          "y" : 896
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1273,
          "y" : 810
        },
        "b" : {
          "x" : 1269,
          "y" : 803
        },
        "c" : {
          "x" : 1265,
          "y" : 810
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1265,
          "y" : 810
        }
      }
    } ]
  }, {
    "id" : 33576,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1308,
      "y" : 636
    },
    "minX" : 1258,
    "maxX" : 1330,
    "minY" : 620,
    "maxY" : 689,
    "prop" : {
      "x" : 1288,
      "y" : 621,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1292,
      "y" : 625
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1324,
          "y" : 626
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1324,
          "y" : 626
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33574,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1293,
          "y" : 654
        },
        "to" : {
          "x" : 1258,
          "y" : 689
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1269,
            "y" : 665
          },
          "b" : {
            "x" : 1281,
            "y" : 677
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1275,
            "y" : 671
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1291,
          "y" : 662
        },
        "b" : {
          "x" : 1293,
          "y" : 654
        },
        "c" : {
          "x" : 1285,
          "y" : 656
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1285,
          "y" : 656
        }
      }
    } ]
  }, {
    "id" : 33578,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1055,
      "y" : 903
    },
    "minX" : 1035,
    "maxX" : 1136,
    "minY" : 887,
    "maxY" : 919,
    "prop" : {
      "x" : 1035,
      "y" : 888,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1039,
      "y" : 893
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1070,
          "y" : 893
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1070,
          "y" : 893
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33577,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1078,
          "y" : 900
        },
        "to" : {
          "x" : 1136,
          "y" : 892
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1101,
            "y" : 890
          },
          "b" : {
            "x" : 1113,
            "y" : 902
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1107,
            "y" : 896
          }
        }
      }
    } ]
  }, {
    "id" : 33579,
    "reactomeId" : 10853871,
    "displayName" : "p-S CALD1-Calcium Bound Myosin Actin Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1129,
      "y" : 840
    },
    "minX" : 1065,
    "maxX" : 1200,
    "minY" : 809,
    "maxY" : 892,
    "prop" : {
      "x" : 1065,
      "y" : 815,
      "width" : 129,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1063,
      "y" : 817
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1194,
          "y" : 815
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1194,
          "y" : 815
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33577,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1132,
          "y" : 869
        },
        "to" : {
          "x" : 1136,
          "y" : 892
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33580,
    "reactomeId" : 10853862,
    "displayName" : "ATP:Calcium Bound Myosin Actin Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1151,
      "y" : 965
    },
    "minX" : 1088,
    "maxX" : 1221,
    "minY" : 934,
    "maxY" : 990,
    "prop" : {
      "x" : 1088,
      "y" : 940,
      "width" : 127,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1086,
      "y" : 941
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1215,
          "y" : 940
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1215,
          "y" : 940
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33577,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33581,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33582,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1314,
      "y" : 880
    },
    "minX" : 1269,
    "maxX" : 1329,
    "minY" : 864,
    "maxY" : 896,
    "prop" : {
      "x" : 1301,
      "y" : 865,
      "width" : 27,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1305,
      "y" : 869
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1323,
          "y" : 870
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1323,
          "y" : 870
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33581,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1298,
          "y" : 884
        },
        "to" : {
          "x" : 1269,
          "y" : 896
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1277,
            "y" : 884
          },
          "b" : {
            "x" : 1289,
            "y" : 896
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1283,
            "y" : 890
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1293,
          "y" : 890
        },
        "b" : {
          "x" : 1298,
          "y" : 884
        },
        "c" : {
          "x" : 1290,
          "y" : 883
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1290,
          "y" : 883
        }
      }
    } ]
  }, {
    "id" : 33583,
    "reactomeId" : 10853782,
    "displayName" : "ATP Bound Smooth Muscle Myosin Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1262,
      "y" : 1038
    },
    "minX" : 1200,
    "maxX" : 1331,
    "minY" : 940,
    "maxY" : 1063,
    "prop" : {
      "x" : 1200,
      "y" : 1013,
      "width" : 125,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1209,
      "y" : 1014
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1325,
          "y" : 1013
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1325,
          "y" : 1013
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33581,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1259,
          "y" : 1010
        },
        "to" : {
          "x" : 1253,
          "y" : 948
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1253,
          "y" : 944
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1253,
          "y" : 944
        }
      }
    } ]
  }, {
    "id" : 33585,
    "reactomeId" : 9620451,
    "displayName" : "sGC stimulators",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 234,
      "y" : 272
    },
    "minX" : 186,
    "maxX" : 282,
    "minY" : 235,
    "maxY" : 293,
    "prop" : {
      "x" : 186,
      "y" : 252,
      "width" : 96,
      "height" : 41
    },
    "textPosition" : {
      "x" : 195,
      "y" : 255
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 33584,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 254,
          "y" : 246
        },
        "to" : {
          "x" : 271,
          "y" : 235
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33586,
    "reactomeId" : 10903075,
    "displayName" : "Guanylate cyclase:NO",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 227,
      "y" : 184
    },
    "minX" : 191,
    "maxX" : 271,
    "minY" : 105,
    "maxY" : 235,
    "prop" : {
      "x" : 191,
      "y" : 165,
      "width" : 72,
      "height" : 39
    },
    "textPosition" : {
      "x" : 190,
      "y" : 155
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 263,
          "y" : 165
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 263,
          "y" : 165
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33584,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 243,
          "y" : 207
        },
        "to" : {
          "x" : 271,
          "y" : 235
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33588,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 223,
          "y" : 162
        },
        "to" : {
          "x" : 214,
          "y" : 105
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33587,
    "reactomeId" : 10903077,
    "displayName" : "NO:sGC:sGC stimulators",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 372,
      "y" : 259
    },
    "minX" : 327,
    "maxX" : 424,
    "minY" : 235,
    "maxY" : 278,
    "prop" : {
      "x" : 327,
      "y" : 241,
      "width" : 91,
      "height" : 37
    },
    "textPosition" : {
      "x" : 329,
      "y" : 243
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 418,
          "y" : 241
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 418,
          "y" : 241
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33584,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33589,
    "reactomeId" : 9621121,
    "displayName" : "cinaciguat",
    "schemaClass" : "ChemicalDrug",
    "renderableClass" : "ChemicalDrug",
    "position" : {
      "x" : 134,
      "y" : 107
    },
    "minX" : 86,
    "maxX" : 214,
    "minY" : 90,
    "maxY" : 124,
    "prop" : {
      "x" : 86,
      "y" : 90,
      "width" : 97,
      "height" : 34
    },
    "textPosition" : {
      "x" : 98,
      "y" : 96
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 33588,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 186,
          "y" : 105
        },
        "to" : {
          "x" : 214,
          "y" : 105
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33590,
    "reactomeId" : 10903173,
    "displayName" : "NO:sGC:cinaciguat",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 307,
      "y" : 109
    },
    "minX" : 260,
    "maxX" : 361,
    "minY" : 80,
    "maxY" : 133,
    "prop" : {
      "x" : 260,
      "y" : 86,
      "width" : 95,
      "height" : 47
    },
    "textPosition" : {
      "x" : 271,
      "y" : 98
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 355,
          "y" : 86
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 355,
          "y" : 86
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33588,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33592,
    "reactomeId" : 10904664,
    "displayName" : "PDE5A dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 884,
      "y" : 88
    },
    "minX" : 811,
    "maxX" : 933,
    "minY" : 60,
    "maxY" : 99,
    "prop" : {
      "x" : 841,
      "y" : 77,
      "width" : 86,
      "height" : 22
    },
    "textPosition" : {
      "x" : 857,
      "y" : 64
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 927,
          "y" : 77
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 927,
          "y" : 77
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33591,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 855,
          "y" : 74
        },
        "to" : {
          "x" : 811,
          "y" : 60
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33593,
    "reactomeId" : 9708098,
    "displayName" : "PDE5A inhibitors",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 879,
      "y" : 28
    },
    "minX" : 811,
    "maxX" : 933,
    "minY" : 17,
    "maxY" : 60,
    "prop" : {
      "x" : 826,
      "y" : 17,
      "width" : 107,
      "height" : 22
    },
    "textPosition" : {
      "x" : 846,
      "y" : 11
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 33591,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 855,
          "y" : 45
        },
        "to" : {
          "x" : 811,
          "y" : 60
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33594,
    "reactomeId" : 10904666,
    "displayName" : "PDE5A dimer:PDE5A inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 713,
      "y" : 61
    },
    "minX" : 653,
    "maxX" : 780,
    "minY" : 38,
    "maxY" : 79,
    "prop" : {
      "x" : 653,
      "y" : 44,
      "width" : 121,
      "height" : 35
    },
    "textPosition" : {
      "x" : 658,
      "y" : 44
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 774,
          "y" : 44
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 774,
          "y" : 44
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33591,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 33584,
    "reactomeId" : 10903079,
    "displayName" : "sGC stimulators bind sGC:NO",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 272,
      "y" : 234
    },
    "minX" : 266,
    "maxX" : 324,
    "minY" : 228,
    "maxY" : 247,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 271,
        "y" : 235
      },
      "to" : {
        "x" : 272,
        "y" : 234
      }
    }, {
      "from" : {
        "x" : 272,
        "y" : 234
      },
      "to" : {
        "x" : 324,
        "y" : 247
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 316,
        "y" : 249
      },
      "b" : {
        "x" : 324,
        "y" : 247
      },
      "c" : {
        "x" : 318,
        "y" : 241
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 318,
        "y" : 241
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 272,
        "y" : 234
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 272,
        "y" : 234
      }
    },
    "inputs" : [ {
      "id" : 33585,
      "points" : [ {
        "x" : 254,
        "y" : 246
      } ]
    }, {
      "id" : 33586,
      "points" : [ {
        "x" : 243,
        "y" : 207
      } ]
    } ],
    "outputs" : [ {
      "id" : 33587
    } ]
  }, {
    "id" : 33570,
    "reactomeId" : 10853883,
    "displayName" : "Calcium Binds Caldesmon",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1198,
      "y" : 562
    },
    "minX" : 1192,
    "maxX" : 1204,
    "minY" : 533,
    "maxY" : 596,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1195,
        "y" : 533
      },
      "to" : {
        "x" : 1198,
        "y" : 562
      }
    }, {
      "from" : {
        "x" : 1198,
        "y" : 562
      },
      "to" : {
        "x" : 1202,
        "y" : 596
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1197,
        "y" : 590
      },
      "b" : {
        "x" : 1202,
        "y" : 596
      },
      "c" : {
        "x" : 1205,
        "y" : 589
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1205,
        "y" : 589
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1198,
        "y" : 562
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1198,
        "y" : 562
      }
    },
    "inputs" : [ {
      "id" : 33571,
      "points" : [ {
        "x" : 1148,
        "y" : 512
      } ]
    }, {
      "id" : 33572,
      "points" : [ {
        "x" : 1195,
        "y" : 486
      } ]
    } ],
    "outputs" : [ {
      "id" : 33573
    } ]
  }, {
    "id" : 33588,
    "reactomeId" : 10903175,
    "displayName" : "Cinaciguat binds sGC:NO",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 214,
      "y" : 104
    },
    "minX" : 208,
    "maxX" : 257,
    "minY" : 98,
    "maxY" : 110,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 214,
        "y" : 105
      },
      "to" : {
        "x" : 214,
        "y" : 104
      }
    }, {
      "from" : {
        "x" : 214,
        "y" : 104
      },
      "to" : {
        "x" : 257,
        "y" : 106
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 250,
        "y" : 110
      },
      "b" : {
        "x" : 257,
        "y" : 106
      },
      "c" : {
        "x" : 250,
        "y" : 102
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 250,
        "y" : 102
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 214,
        "y" : 104
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 214,
        "y" : 104
      }
    },
    "inputs" : [ {
      "id" : 33589,
      "points" : [ {
        "x" : 186,
        "y" : 105
      } ]
    }, {
      "id" : 33586,
      "points" : [ {
        "x" : 223,
        "y" : 162
      } ]
    } ],
    "outputs" : [ {
      "id" : 33590
    } ]
  }, {
    "id" : 33574,
    "reactomeId" : 10853885,
    "displayName" : "Release Of ADP From Myosin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1269,
      "y" : 725
    },
    "minX" : 1258,
    "maxX" : 1275,
    "minY" : 689,
    "maxY" : 747,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 1269,
        "y" : 747
      },
      "to" : {
        "x" : 1269,
        "y" : 725
      }
    }, {
      "from" : {
        "x" : 1269,
        "y" : 725
      },
      "to" : {
        "x" : 1258,
        "y" : 689
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 1269,
        "y" : 725
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 1269,
        "y" : 725
      }
    },
    "inputs" : [ {
      "id" : 33575
    } ],
    "outputs" : [ {
      "id" : 33573,
      "points" : [ {
        "x" : 1225,
        "y" : 652
      } ]
    }, {
      "id" : 33576,
      "points" : [ {
        "x" : 1293,
        "y" : 654
      } ],
      "stoichiometry" : 2
    } ]
  }, {
    "id" : 33591,
    "reactomeId" : 10904668,
    "displayName" : "PDE5A dimer binds PDE5A inhibitors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 812,
      "y" : 60
    },
    "minX" : 777,
    "maxX" : 818,
    "minY" : 54,
    "maxY" : 66,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 811,
        "y" : 60
      },
      "to" : {
        "x" : 812,
        "y" : 60
      }
    }, {
      "from" : {
        "x" : 812,
        "y" : 60
      },
      "to" : {
        "x" : 777,
        "y" : 60
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 784,
        "y" : 56
      },
      "b" : {
        "x" : 777,
        "y" : 60
      },
      "c" : {
        "x" : 784,
        "y" : 64
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 784,
        "y" : 64
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 812,
        "y" : 60
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 812,
        "y" : 60
      }
    },
    "inputs" : [ {
      "id" : 33592,
      "points" : [ {
        "x" : 855,
        "y" : 74
      } ]
    }, {
      "id" : 33593,
      "points" : [ {
        "x" : 855,
        "y" : 45
      } ]
    } ],
    "outputs" : [ {
      "id" : 33594
    } ]
  }, {
    "id" : 33577,
    "reactomeId" : 10853873,
    "displayName" : "Myosin Binds ATP",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1133,
      "y" : 909
    },
    "minX" : 1127,
    "maxX" : 1142,
    "minY" : 892,
    "maxY" : 937,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1136,
        "y" : 892
      },
      "to" : {
        "x" : 1133,
        "y" : 909
      }
    }, {
      "from" : {
        "x" : 1133,
        "y" : 909
      },
      "to" : {
        "x" : 1142,
        "y" : 937
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1136,
        "y" : 932
      },
      "b" : {
        "x" : 1142,
        "y" : 937
      },
      "c" : {
        "x" : 1144,
        "y" : 929
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1144,
        "y" : 929
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1133,
        "y" : 909
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1133,
        "y" : 909
      }
    },
    "inputs" : [ {
      "id" : 33578,
      "points" : [ {
        "x" : 1078,
        "y" : 900
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 33579,
      "points" : [ {
        "x" : 1132,
        "y" : 869
      } ]
    } ],
    "outputs" : [ {
      "id" : 33580
    } ]
  }, {
    "id" : 33581,
    "reactomeId" : 10853869,
    "displayName" : "ATP Hydrolysis By Myosin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1252,
      "y" : 932
    },
    "minX" : 1218,
    "maxX" : 1269,
    "minY" : 896,
    "maxY" : 944,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1218,
        "y" : 944
      },
      "to" : {
        "x" : 1252,
        "y" : 932
      }
    }, {
      "from" : {
        "x" : 1252,
        "y" : 932
      },
      "to" : {
        "x" : 1269,
        "y" : 896
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1246,
        "y" : 926
      },
      "b" : {
        "x" : 1258,
        "y" : 938
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1252,
        "y" : 932
      }
    },
    "inputs" : [ {
      "id" : 33580
    } ],
    "outputs" : [ {
      "id" : 33575,
      "points" : [ {
        "x" : 1269,
        "y" : 803
      } ]
    }, {
      "id" : 33582,
      "points" : [ {
        "x" : 1298,
        "y" : 884
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 33583,
      "points" : [ {
        "x" : 1259,
        "y" : 1010
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 33601,
    "reactomeId" : 437050,
    "displayName" : "cytoplasmic vesicle lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 141,
      "y" : 895
    },
    "minX" : 26,
    "maxX" : 257,
    "minY" : 839,
    "maxY" : 951,
    "prop" : {
      "x" : 26,
      "y" : 839,
      "width" : 231,
      "height" : 112
    },
    "textPosition" : {
      "x" : 33,
      "y" : 871
    },
    "insets" : {
      "x" : 36,
      "y" : 849,
      "width" : 211,
      "height" : 92
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 33609,
    "reactomeId" : 5460,
    "displayName" : "mitochondrial matrix",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 207,
      "y" : 520
    },
    "minX" : 34,
    "maxX" : 380,
    "minY" : 433,
    "maxY" : 608,
    "prop" : {
      "x" : 34,
      "y" : 433,
      "width" : 346,
      "height" : 175
    },
    "textPosition" : {
      "x" : 230,
      "y" : 563
    },
    "insets" : {
      "x" : 44,
      "y" : 443,
      "width" : 326,
      "height" : 155
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 33595,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 682,
      "y" : 560
    },
    "minX" : 0,
    "maxX" : 1365,
    "minY" : 0,
    "maxY" : 1121,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1365,
      "height" : 1121
    },
    "textPosition" : {
      "x" : 16,
      "y" : 19
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1345,
      "height" : 1101
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 33572, 33570, 33571, 33573, 33574, 33575, 33576, 33577, 33580, 33581, 33582, 33583, 33601, 33586, 33609, 33584, 33585, 33587, 33590, 33588, 33589, 33592, 33591, 33593, 33594, 33578, 33579 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1365,
  "minY" : 0,
  "maxY" : 1121,
  "disease" : false
}