{
  "dbId" : 10911262,
  "stId" : "R-DME-166058",
  "speciesName" : "Drosophila melanogaster",
  "nodes" : [ {
    "dbId" : 10839589,
    "stId" : "R-DME-450152",
    "displayName" : "K63polyUb [cytosol]",
    "schemaClass" : "Polymer",
    "speciesId" : 56210,
    "diagramIds" : [ 87236, 87244 ],
    "parents" : [ ],
    "children" : [ 10839587 ]
  }, {
    "dbId" : 10842917,
    "stId" : "R-DME-168104",
    "displayName" : "CHUK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q9VEZ5",
    "standardIdentifier" : "uniprot:Q9VEZ5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IKKbeta", "DIK", "ird5", "CG4201" ],
    "parents" : [ 10844010 ],
    "children" : [ ]
  }, {
    "dbId" : 10854758,
    "stId" : "R-DME-450815",
    "displayName" : "phospho-Pli [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "diagramIds" : [ 87230 ],
    "identifier" : "O77237",
    "standardIdentifier" : "uniprot:O77237",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Pli" ],
    "parents" : [ 10858463 ],
    "children" : [ ]
  }, {
    "dbId" : 10839587,
    "stId" : "R-DME-450143",
    "displayName" : "K63-Ub [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 56210,
    "parents" : [ 10839589 ],
    "children" : [ 10839546, 10839561, 10839549, 10839552 ]
  }, {
    "dbId" : 10855010,
    "stId" : "R-DME-451565",
    "displayName" : "phospho-K63polyUb-hp-IRAK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q05652",
    "standardIdentifier" : "uniprot:Q05652",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "pll", "CG5974" ],
    "parents" : [ 10858453 ],
    "children" : [ ]
  }, {
    "dbId" : 10844008,
    "stId" : "R-DME-168114",
    "displayName" : "IKBKB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q9VEZ5",
    "standardIdentifier" : "uniprot:Q9VEZ5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IKKbeta", "DIK", "ird5", "CG4201" ],
    "parents" : [ 10844010 ],
    "children" : [ ]
  }, {
    "dbId" : 10829864,
    "stId" : "R-DME-113595",
    "displayName" : "Ub [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 56210,
    "diagramIds" : [ 87241 ],
    "parents" : [ ],
    "children" : [ 10829846, 1221559, 1221557, 1221562, 1221561, 1221567, 10829848 ]
  }, {
    "dbId" : 10844010,
    "stId" : "R-DME-168113",
    "displayName" : "CHUK:IKBKB:IKBKG [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 87246 ],
    "parents" : [ 10858455 ],
    "children" : [ 10844008, 10839478, 10842917 ]
  }, {
    "dbId" : 10844020,
    "stId" : "R-DME-205753",
    "displayName" : "Uev1A [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q9VRL1",
    "standardIdentifier" : "uniprot:Q9VRL1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Uev1A", "CG10640", "Dmel_CG10640" ],
    "parents" : [ 10844022 ],
    "children" : [ ]
  }, {
    "dbId" : 10844022,
    "stId" : "R-DME-202463",
    "displayName" : "UBE2N:UBE2V1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 87237 ],
    "parents" : [ ],
    "children" : [ 10844016, 10844020 ]
  }, {
    "dbId" : 10839478,
    "stId" : "R-DME-168108",
    "displayName" : "IKBKG [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q9GYV5",
    "standardIdentifier" : "uniprot:Q9GYV5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "key", "IKKGAMMA", "CG16910" ],
    "parents" : [ 10844010 ],
    "children" : [ ]
  }, {
    "dbId" : 10844016,
    "stId" : "R-DME-206072",
    "displayName" : "ben [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P35128",
    "standardIdentifier" : "uniprot:P35128",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ben", "UbcD3", "CG18319" ],
    "parents" : [ 10844022 ],
    "children" : [ ]
  }, {
    "dbId" : 10839549,
    "stId" : "R-DME-939169",
    "displayName" : "Ubi-p5E [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q9W418",
    "standardIdentifier" : "uniprot:Q9W418",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubi-p5E" ],
    "parents" : [ 10839587 ],
    "children" : [ ]
  }, {
    "dbId" : 10912764,
    "stId" : "R-DME-5686938",
    "displayName" : "Regulation of TLR by endogenous ligand",
    "schemaClass" : "Pathway",
    "speciesId" : 56210,
    "diagramIds" : [ 87271 ]
  }, {
    "dbId" : 10839546,
    "stId" : "R-DME-939248",
    "displayName" : "RpL40 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P18101",
    "standardIdentifier" : "uniprot:P18101",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RpL40", "Ubi-f", "UBI-F52", "CG2960" ],
    "parents" : [ 10839587 ],
    "children" : [ ]
  }, {
    "dbId" : 10858436,
    "stId" : "R-DME-936961",
    "displayName" : "TRAF6:p-IRAK2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 87225 ],
    "parents" : [ 10858438 ],
    "children" : [ 10858434, 10858432 ]
  }, {
    "dbId" : 10911300,
    "stId" : "R-DME-445989",
    "displayName" : "TAK1-dependent IKK and NF-kappa-B activation  ",
    "schemaClass" : "Pathway",
    "speciesId" : 56210,
    "diagramIds" : [ 87259 ]
  }, {
    "dbId" : 10858438,
    "stId" : "R-DME-936990",
    "displayName" : "p-IRAK2:oligo-TRAF6 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 87227 ],
    "parents" : [ ],
    "children" : [ 10858432, 10858436 ]
  }, {
    "dbId" : 10858432,
    "stId" : "R-DME-936955",
    "displayName" : "Traf6 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q9W3I9",
    "standardIdentifier" : "uniprot:Q9W3I9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Traf6" ],
    "parents" : [ 10858461, 10858438, 10858436 ],
    "children" : [ ]
  }, {
    "dbId" : 10839552,
    "stId" : "R-DME-939224",
    "displayName" : "Ubi-p63E [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P0CG69",
    "standardIdentifier" : "uniprot:P0CG69",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubi-p63E", "Ubi-m", "CG11624" ],
    "parents" : [ 10839587 ],
    "children" : [ ]
  }, {
    "dbId" : 10854144,
    "stId" : "R-DME-166366",
    "displayName" : "Traf6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "diagramIds" : [ 87226 ],
    "identifier" : "Q9W3I9",
    "standardIdentifier" : "uniprot:Q9W3I9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Traf6" ],
    "parents" : [ 10858453 ],
    "children" : [ ]
  }, {
    "dbId" : 1221559,
    "stId" : "R-DME-1221559",
    "displayName" : "UBI-P63E 3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P0CG69",
    "standardIdentifier" : "uniprot:P0CG69",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubi-p63E", "Ubi-m", "CG11624" ],
    "parents" : [ 10829864 ],
    "children" : [ ]
  }, {
    "dbId" : 10858434,
    "stId" : "R-DME-936949",
    "displayName" : "phospho-p-IRAK2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q05652",
    "standardIdentifier" : "uniprot:Q05652",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "pll", "CG5974" ],
    "parents" : [ 10858436, 10858443 ],
    "children" : [ ]
  }, {
    "dbId" : 1221557,
    "stId" : "R-DME-1221557",
    "displayName" : "UBI-P63E 2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P0CG69",
    "standardIdentifier" : "uniprot:P0CG69",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubi-p63E", "Ubi-m", "CG11624" ],
    "parents" : [ 10829864 ],
    "children" : [ ]
  }, {
    "dbId" : 1221562,
    "stId" : "R-DME-1221562",
    "displayName" : "UBI-P63E 11 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P15357",
    "standardIdentifier" : "uniprot:P15357",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RpS27A", "UB3-D", "UBI-F80", "Ubi-m", "CG5271" ],
    "parents" : [ 10829864 ],
    "children" : [ ]
  }, {
    "dbId" : 1221561,
    "stId" : "R-DME-1221561",
    "displayName" : "UBI-P63E 12 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P18101",
    "standardIdentifier" : "uniprot:P18101",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RpL40", "Ubi-f", "UBI-F52", "CG2960" ],
    "parents" : [ 10829864 ],
    "children" : [ ]
  }, {
    "dbId" : 10911242,
    "stId" : "R-DME-450294",
    "displayName" : "MAP kinase activation",
    "schemaClass" : "Pathway",
    "speciesId" : 56210,
    "diagramIds" : [ 87258 ]
  }, {
    "dbId" : 10839561,
    "stId" : "R-DME-939176",
    "displayName" : "RpS27A [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P15357",
    "standardIdentifier" : "uniprot:P15357",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RpS27A", "UB3-D", "UBI-F80", "Ubi-m", "CG5271" ],
    "parents" : [ 10839587 ],
    "children" : [ ]
  }, {
    "dbId" : 10858441,
    "stId" : "R-DME-936980",
    "displayName" : "Traf6 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q9W3I9",
    "standardIdentifier" : "uniprot:Q9W3I9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Traf6" ],
    "parents" : [ 10858443 ],
    "children" : [ ]
  }, {
    "dbId" : 1221567,
    "stId" : "R-DME-1221567",
    "displayName" : "UBI-P63E 1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P0CG69",
    "standardIdentifier" : "uniprot:P0CG69",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubi-p63E", "Ubi-m", "CG11624" ],
    "parents" : [ 10829864 ],
    "children" : [ ]
  }, {
    "dbId" : 10858443,
    "stId" : "R-DME-936988",
    "displayName" : "p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 87242 ],
    "parents" : [ ],
    "children" : [ 10858441, 10858434 ]
  }, {
    "dbId" : 10858453,
    "stId" : "R-DME-937043",
    "displayName" : "K63-linked polyUb p-IRAK1:TRAF6 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 87239 ],
    "parents" : [ 10858455 ],
    "children" : [ 10855010, 10854144 ]
  }, {
    "dbId" : 10858455,
    "stId" : "R-DME-937038",
    "displayName" : "TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 87247 ],
    "parents" : [ ],
    "children" : [ 10844010, 10858453 ]
  }, {
    "dbId" : 10829846,
    "stId" : "R-DME-939203",
    "displayName" : "Ubi-p5E [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q9W418",
    "standardIdentifier" : "uniprot:Q9W418",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubi-p5E" ],
    "parents" : [ 10829864 ],
    "children" : [ ]
  }, {
    "dbId" : 10858461,
    "stId" : "R-DME-937036",
    "displayName" : "TRAF6:hp-IRAK1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 87229 ],
    "parents" : [ 10858463 ],
    "children" : [ 10858459, 10858432 ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87233 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10858463,
    "stId" : "R-DME-937020",
    "displayName" : "TRAF6:hp-IRAK1:Pellino [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 87238, 87231 ],
    "parents" : [ ],
    "children" : [ 10858461, 10854758 ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87234 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10829848,
    "stId" : "R-DME-939164",
    "displayName" : "RpS27A [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P15357",
    "standardIdentifier" : "uniprot:P15357",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RpS27A", "UB3-D", "UBI-F80", "Ubi-m", "CG5271" ],
    "parents" : [ 10829864 ],
    "children" : [ ]
  }, {
    "dbId" : 10858459,
    "stId" : "R-DME-937011",
    "displayName" : "phospho-p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q05652",
    "standardIdentifier" : "uniprot:Q05652",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "pll", "CG5974" ],
    "parents" : [ 10858461 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10858468,
    "stId" : "R-DME-937044",
    "displayName" : "Pellino binds hp-IRAK1:TRAF6",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10858466 ],
    "inputs" : [ 10858461, 10854758 ],
    "outputs" : [ 10858463 ],
    "efs" : [ ],
    "diagramIds" : [ 87228 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10858471,
    "stId" : "R-DME-937050",
    "displayName" : "Pellino ubiquitinates hp-IRAK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10858466 ],
    "following" : [ 10858457 ],
    "inputs" : [ 10858463, 10844022, 10839589 ],
    "outputs" : [ 10844022, 10854758, 10858453 ],
    "catalysts" : [ 10858463 ],
    "efs" : [ ],
    "diagramIds" : [ 87235 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10858448,
    "stId" : "R-DME-936963",
    "displayName" : "IRAK2 induces TRAF6 oligomerization",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10858446 ],
    "inputs" : [ 10854144, 10858436 ],
    "outputs" : [ 10858438 ],
    "efs" : [ ],
    "diagramIds" : [ 87224 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10858451,
    "stId" : "R-DME-936986",
    "displayName" : "Activated TRAF6 synthesizes unanchored polyubiquitin chains",
    "schemaClass" : "Polymerisation",
    "speciesId" : 0,
    "preceding" : [ 10858446 ],
    "inputs" : [ 10829864 ],
    "outputs" : [ 10839589 ],
    "catalysts" : [ 10858443 ],
    "efs" : [ ],
    "diagramIds" : [ 87243 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10858466,
    "stId" : "R-DME-937034",
    "displayName" : "IRAK1 phosphorylates Pellino",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10858468 ],
    "following" : [ 10858471 ],
    "inputs" : [ 10858463, 113592 ],
    "outputs" : [ 10858463, 29370 ],
    "catalysts" : [ 10858463 ],
    "efs" : [ ],
    "diagramIds" : [ 87232 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10858446,
    "stId" : "R-DME-936942",
    "displayName" : "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10858448 ],
    "following" : [ 10858451 ],
    "inputs" : [ 10829864, 10858438 ],
    "outputs" : [ 10858443 ],
    "catalysts" : [ 10858438 ],
    "efs" : [ ],
    "diagramIds" : [ 87240 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10858457,
    "stId" : "R-DME-937032",
    "displayName" : "NEMO subunit of IKK complex binds to activated IRAK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10858471 ],
    "inputs" : [ 10844010, 10858453 ],
    "outputs" : [ 10858455 ],
    "efs" : [ ],
    "diagramIds" : [ 87245 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10912214,
    "stId" : "R-DME-937039",
    "displayName" : "IRAK1 recruits IKK complex",
    "events" : [ 10858468, 10858471, 10858466, 10858457 ]
  }, {
    "dbId" : 10912212,
    "stId" : "R-DME-937042",
    "displayName" : "IRAK2 mediated activation of TAK1 complex",
    "events" : [ 10858448, 10858451, 10858446 ]
  } ]
}