{
  "dbId" : 10911102,
  "stId" : "R-DME-416476",
  "speciesName" : "Drosophila melanogaster",
  "nodes" : [ {
    "dbId" : 10836389,
    "stId" : "R-DME-61747",
    "displayName" : "PLCB3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P25455",
    "standardIdentifier" : "uniprot:P25455",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10836396 ],
    "children" : [ ]
  }, {
    "dbId" : 10900964,
    "stId" : "R-DME-8982013",
    "displayName" : "G alpha (q):GDP:RGS [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 124249 ],
    "parents" : [ ],
    "children" : [ 29420, 10900944, 10836401 ]
  }, {
    "dbId" : 10836385,
    "stId" : "R-DME-61693",
    "displayName" : "PLCB1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P25455",
    "standardIdentifier" : "uniprot:P25455",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10836396 ],
    "children" : [ ]
  }, {
    "dbId" : 10836387,
    "stId" : "R-DME-61695",
    "displayName" : "PLCB2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P25455",
    "standardIdentifier" : "uniprot:P25455",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10836396 ],
    "children" : [ ]
  }, {
    "dbId" : 10850210,
    "stId" : "R-DME-416515",
    "displayName" : "G-protein alpha (q):GRK2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 124230 ],
    "parents" : [ ],
    "children" : [ 10836616, 10836403 ]
  }, {
    "dbId" : 10911598,
    "stId" : "R-DME-881907",
    "displayName" : "Gastrin-CREB signalling pathway via PKC and MAPK",
    "schemaClass" : "Pathway",
    "speciesId" : 56210,
    "diagramIds" : [ 124264 ]
  }, {
    "dbId" : 10900591,
    "stId" : "R-DME-8964296",
    "displayName" : "Active Gq:BTK [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 124240, 124243 ],
    "parents" : [ ],
    "children" : [ 10871119, 10836403 ]
  }, {
    "dbId" : 10836396,
    "stId" : "R-DME-111854",
    "displayName" : "PLC-beta [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 56210,
    "parents" : [ 10836405 ],
    "children" : [ 10836394, 10836387, 10836385, 10836389 ]
  }, {
    "dbId" : 10836394,
    "stId" : "R-DME-61697",
    "displayName" : "PLCB4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P13217",
    "standardIdentifier" : "uniprot:P13217",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10836396 ],
    "children" : [ ]
  }, {
    "dbId" : 10911670,
    "stId" : "R-DME-397795",
    "displayName" : "G-protein beta:gamma signalling",
    "schemaClass" : "Pathway",
    "speciesId" : 56210,
    "diagramIds" : [ 124263 ]
  }, {
    "dbId" : 10836405,
    "stId" : "R-DME-111856",
    "displayName" : "Activated PLC beta 1/4 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 124237 ],
    "parents" : [ 10837265, 10837263 ],
    "children" : [ 10836396, 10836403 ]
  }, {
    "dbId" : 179856,
    "stId" : "R-ALL-179856",
    "displayName" : "PI(4,5)P2 [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "58456",
    "standardIdentifier" : "chebi:58456",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10837263 ],
    "children" : [ ]
  }, {
    "dbId" : 10900917,
    "stId" : "R-DME-939779",
    "displayName" : "Dhit [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q8T017",
    "standardIdentifier" : "uniprot:Q8T017",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dhit" ],
    "parents" : [ 10900944 ],
    "children" : [ ]
  }, {
    "dbId" : 10836401,
    "stId" : "R-DME-55453",
    "displayName" : "GNAQ [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "P23625",
    "standardIdentifier" : "uniprot:P23625",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10900964, 10850450, 10836403 ],
    "children" : [ ]
  }, {
    "dbId" : 10836403,
    "stId" : "R-DME-167438",
    "displayName" : "G protein alpha:GTP complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 124228 ],
    "parents" : [ 10900591, 10850201, 10850210, 10900946, 10836405 ],
    "children" : [ 29438, 10836401 ]
  }, {
    "dbId" : 114519,
    "stId" : "R-ALL-114519",
    "displayName" : "DAG [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "17815",
    "standardIdentifier" : "chebi:17815",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10837265 ],
    "children" : [ ]
  }, {
    "dbId" : 114520,
    "stId" : "R-ALL-114520",
    "displayName" : "I(1,4,5)P3 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "203600",
    "standardIdentifier" : "chebi:203600",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10837265 ],
    "children" : [ ]
  }, {
    "dbId" : 10845178,
    "stId" : "R-DME-2980605",
    "displayName" : "trio [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "diagramIds" : [ 124232 ],
    "identifier" : "Q7KVD1",
    "standardIdentifier" : "uniprot:Q7KVD1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "trio" ],
    "parents" : [ 10850201 ],
    "children" : [ ]
  }, {
    "dbId" : 10871119,
    "stId" : "R-DME-197948",
    "displayName" : "BTK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "diagramIds" : [ 124244, 124239 ],
    "identifier" : "P08630",
    "standardIdentifier" : "uniprot:P08630",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10900591 ],
    "children" : [ ]
  }, {
    "dbId" : 10837263,
    "stId" : "R-DME-8983508",
    "displayName" : "PLC-beta:G-alpha(q/11):PIP2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 124235 ],
    "parents" : [ ],
    "children" : [ 179856, 10836405 ]
  }, {
    "dbId" : 29420,
    "stId" : "R-ALL-29420",
    "displayName" : "GDP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "58189",
    "standardIdentifier" : "chebi:58189",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10900964 ],
    "children" : [ ]
  }, {
    "dbId" : 10836616,
    "stId" : "R-DME-50270",
    "displayName" : "GRK2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "diagramIds" : [ 124229 ],
    "identifier" : "P32865",
    "standardIdentifier" : "uniprot:P32865",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10850210 ],
    "children" : [ ]
  }, {
    "dbId" : 10911112,
    "stId" : "R-DME-114508",
    "displayName" : "Effects of PIP2 hydrolysis",
    "schemaClass" : "Pathway",
    "speciesId" : 56210,
    "diagramIds" : [ 124265 ]
  }, {
    "dbId" : 10900946,
    "stId" : "R-DME-8982027",
    "displayName" : "G alpha (q):GTP:RGS [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 124247 ],
    "parents" : [ ],
    "children" : [ 10900944, 10836403 ]
  }, {
    "dbId" : 10837265,
    "stId" : "R-DME-8983509",
    "displayName" : "PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 124236 ],
    "parents" : [ ],
    "children" : [ 114520, 114519, 10836405 ]
  }, {
    "dbId" : 114549,
    "stId" : "R-ALL-114549",
    "displayName" : "GDP [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "17552",
    "standardIdentifier" : "chebi:17552",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10850450 ],
    "children" : [ ]
  }, {
    "dbId" : 10900944,
    "stId" : "R-DME-8982302",
    "displayName" : "RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 56210,
    "diagramIds" : [ 124246 ],
    "parents" : [ 10900964, 10900946 ],
    "children" : [ 10850461, 10900917 ]
  }, {
    "dbId" : 10850450,
    "stId" : "R-DME-114556",
    "displayName" : "G-protein alpha (q/11):GDP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 124252 ],
    "parents" : [ ],
    "children" : [ 10836401, 114549 ]
  }, {
    "dbId" : 10850461,
    "stId" : "R-DME-8849410",
    "displayName" : "PsGEF [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q7KVY9",
    "standardIdentifier" : "uniprot:Q7KVY9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PsGEF" ],
    "parents" : [ 10850463, 10900944 ],
    "children" : [ ]
  }, {
    "dbId" : 10850463,
    "stId" : "R-DME-921123",
    "displayName" : "RGS proteins active for G alpha (q) [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 56210,
    "diagramIds" : [ 124254 ],
    "parents" : [ ],
    "children" : [ 10850456, 10850461 ]
  }, {
    "dbId" : 29372,
    "stId" : "R-ALL-29372",
    "displayName" : "Pi [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 124250 ],
    "identifier" : "43474",
    "standardIdentifier" : "chebi:43474",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10850201,
    "stId" : "R-DME-400608",
    "displayName" : "G-protein alpha (q/11):Trio family RhoGEFs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 56210,
    "diagramIds" : [ 124233 ],
    "parents" : [ ],
    "children" : [ 10845178, 10836403 ]
  }, {
    "dbId" : 10850456,
    "stId" : "R-DME-921129",
    "displayName" : "Dhit [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 56210,
    "identifier" : "Q8T017",
    "standardIdentifier" : "uniprot:Q8T017",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dhit" ],
    "parents" : [ 10850463 ],
    "children" : [ ]
  }, {
    "dbId" : 29438,
    "stId" : "R-ALL-29438",
    "displayName" : "GTP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "37565",
    "standardIdentifier" : "chebi:37565",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10836403 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10850212,
    "stId" : "R-DME-416516",
    "displayName" : "GRK2 sequesters activated Gq",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10836616, 10836403 ],
    "outputs" : [ 10850210 ],
    "efs" : [ ],
    "diagramIds" : [ 124227 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10900599,
    "stId" : "R-DME-8964340",
    "displayName" : "Gq-BTK complex dissociates to Active BTK and Gq",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10900595 ],
    "inputs" : [ 10900591 ],
    "outputs" : [ 10871119, 10836403 ],
    "efs" : [ ],
    "diagramIds" : [ 124242 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10900967,
    "stId" : "R-DME-8982025",
    "displayName" : "G alpha (q) in G (q):RGS complex is inactivated",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10900948 ],
    "following" : [ 10900969 ],
    "inputs" : [ 10900946 ],
    "outputs" : [ 29372, 10900964 ],
    "catalysts" : [ 10900946 ],
    "efs" : [ ],
    "diagramIds" : [ 124248 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10837268,
    "stId" : "R-DME-114688",
    "displayName" : "PLC-beta hydrolyses PIP2 to DAG and IP3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10837263 ],
    "outputs" : [ 10837265 ],
    "catalysts" : [ 10836405 ],
    "efs" : [ ],
    "diagramIds" : [ 124234 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10900948,
    "stId" : "R-DME-8982017",
    "displayName" : "Active G alpha (q) binds RGS proteins",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10900967 ],
    "inputs" : [ 10900944, 10836403 ],
    "outputs" : [ 10900946 ],
    "efs" : [ ],
    "diagramIds" : [ 124245 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10850465,
    "stId" : "R-DME-418582",
    "displayName" : "G alpha (q) auto-inactivates by hydrolysing GTP to GDP",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10836403 ],
    "outputs" : [ 10850450 ],
    "catalysts" : [ 10836403 ],
    "efs" : [ ],
    "activators" : [ 10850463 ],
    "diagramIds" : [ 124253 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10900595,
    "stId" : "R-DME-8964284",
    "displayName" : "BTK in active Gq-BTK complex is activated",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10900593 ],
    "following" : [ 10900599 ],
    "inputs" : [ 10900591 ],
    "outputs" : [ 10900591 ],
    "efs" : [ ],
    "diagramIds" : [ 124241 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10900593,
    "stId" : "R-DME-8964280",
    "displayName" : "Active Gq binds BTK",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10900595 ],
    "inputs" : [ 10871119, 10836403 ],
    "outputs" : [ 10900591 ],
    "efs" : [ ],
    "diagramIds" : [ 124238 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10850203,
    "stId" : "R-DME-400586",
    "displayName" : "G alpha (q) binds to Trio family RhoGEFs",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10845178, 10836403 ],
    "outputs" : [ 10850201 ],
    "efs" : [ ],
    "diagramIds" : [ 124231 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10900969,
    "stId" : "R-DME-8982026",
    "displayName" : "G alpha (q):RGS dissociates to inactive G alpha (q)",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10900967 ],
    "inputs" : [ 10900964 ],
    "outputs" : [ 10850450, 10900944 ],
    "efs" : [ ],
    "diagramIds" : [ 124251 ],
    "entityFunctionalStatus" : [ ]
  } ]
}